SWF000001
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 20 21  2  0  0  0  0
 22 23  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000001

>  <SMILES>
O=C(c1ccc2cc[nH]c2c1)N1CCCC2(COCCN(CC3CC3)C2)C1

$$$$
SWF000002
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4553   -1.0311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7701   -3.9500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5549   -2.0513   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2035   -4.3921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000002

>  <SMILES>
COc1cccc(CN2C[C@H]3CCNCC[C@H]3S2(=O)=O)c1

$$$$
SWF000003
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    1.3033   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0557   -1.3033   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5508    1.3033   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7524   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6065    0.7524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3748   -0.1404   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1573   -2.2491   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3817   -1.2587   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6293   -2.5620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9938    0.1161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8769   -3.8652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7629   -2.3189   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1966   -1.7991   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2586   -4.3715   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8838   -4.9836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3750   -0.9441   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5619   -5.1239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
  8  9  1  0  0  0  0
 15 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000003

>  <SMILES>
CN1CCC2(CN(S(C)(=O)=O)CC23CCNCC3)C1=O

$$$$
SWF000004
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.8366   -1.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7215   -3.4820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1996   -2.8239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3906   -4.2251   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3041   -3.8184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0086   -2.2361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2177   -4.2251   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0267   -3.6374   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9402   -4.0441   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0448   -5.0386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7493   -3.4563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9583   -5.4454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6628   -3.8631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7673   -4.8576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6809   -5.2643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  3  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000004

>  <SMILES>
CC1CCN(c2ccc3c(-c4ncc(C(=O)O)s4)noc3c2)CC1

$$$$
SWF000005
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0113   -3.6899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3041   -3.8184   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4381   -5.3184   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  2  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000005

>  <SMILES>
Cc1nc(Cn2cnc(-c3nc(C(=O)O)c4ccccn34)c2)cs1

$$$$
SWF000006
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889   -5.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000006

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCNCC4)nn3c2)c1

$$$$
SWF000007
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7068    1.7909   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000007

>  <SMILES>
O=C(O)c1cc(-c2cnc(-c3ccccc3)nc2)cn1CC1CC1

$$$$
SWF000008
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000008

>  <SMILES>
Cc1ccc(-c2nc(-c3noc4ccc(C(=O)O)cc34)co2)cc1

$$$$
SWF000009
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 21 22  2  0  0  0  0
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 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF000009

>  <SMILES>
O=C(O)c1ccc2onc(-c3csc(-c4ccccc4)n3)c2c1

$$$$
SWF000010
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 14 19  1  0  0  0  0
 16 17  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF000010

>  <SMILES>
O=C(O)c1ncn2c1CN(CC1CC1)S(=O)(=O)c1ccccc1-2

$$$$
SWF000011
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
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 15 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000011

>  <SMILES>
CC(=O)N1CC2(CCN(C(=O)Cc3ccccc3)CC2)c2cc(Cl)ccc21

$$$$
SWF000012
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.7356   -4.5303   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000012

>  <SMILES>
Cc1ccc(-c2nc(-c3noc4ccc(C(=O)O)cc34)cs2)cc1

$$$$
SWF000013
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -4.7655   -8.0429   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2983   -7.7311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2946   -8.8458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000013

>  <SMILES>
O=C(O)c1ccc2onc(-c3coc(-c4ccc(F)cc4)n3)c2c1

$$$$
SWF000014
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000014

>  <SMILES>
CC(C)n1c2ccccc2c2c1cc(C(=O)O)n2C(=O)N(C)C

$$$$
SWF000015
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.3742   -6.1940   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000015

>  <SMILES>
CS(=O)(=O)N1CCC(c2nnc3ccc(C(=O)O)cn23)C1

$$$$
SWF000016
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.5366    1.1939   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 17 22  2  0  0  0  0
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 12 13  1  0  0  0  0
 18 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000016

>  <SMILES>
COCCn1c(C(=O)O)cc2c1c1ccccc1n2C(C)C

$$$$
SWF000017
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.0841   -2.2458   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4355    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2916   -0.2020   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1897    2.9292   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 25  1  0  0  0  0
 10 12  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF000017

>  <SMILES>
CN(C)C(=O)CN1Cc2c(C(=O)O)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF000018
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.8053   -5.6119   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8016   -6.7266   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2688   -7.0384   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2625   -5.2563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5962   -3.1945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2771   -5.3653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8931   -3.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <HTSID>
SWF000018

>  <SMILES>
CCN1Cc2c(C(=O)O)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF000019
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2709   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000019

>  <SMILES>
O=C(O)c1ccc2onc(-c3coc(-c4ccccc4)n3)c2c1

$$$$
SWF000020
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.0841   -2.2458   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000020

>  <SMILES>
CC(C)CCN1Cc2c(C(=O)O)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF000021
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.8366   -1.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000021

>  <SMILES>
O=C(O)c1cnc(-c2noc3cc(-c4ccccc4)ccc23)s1

$$$$
SWF000022
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000022

>  <SMILES>
O=C(CCc1ccccc1)N1CCCC12CCCN(S(=O)(=O)c1ccccc1)C2

$$$$
SWF000023
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000023

>  <SMILES>
O=C(Nc1cccc(Cl)c1)c1nc2c(s1)CCNCC2

$$$$
SWF000024
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1696    0.1874   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0017    2.4281   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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 10 13  1  0  0  0  0
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 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000024

>  <SMILES>
COc1cccc(NC(=O)c2nc3c(s2)CCNCC3)c1

$$$$
SWF000025
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3882   -4.7970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000025

>  <SMILES>
O=C1NC(c2ccccc2)C12CCN(c1ccc3c(c1)OCO3)CC2

$$$$
SWF000026
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000026

>  <SMILES>
COc1cccc(CNC(=O)c2nc3c(s2)CCNCC3)c1

$$$$
SWF000027
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7013    1.4872   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6407    2.5478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2525    1.0989   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6145    2.6772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1016    2.8730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7013    3.8672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2917    1.9598   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6757    4.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 14 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000027

>  <SMILES>
CC(C)CN1CC2(CCNCC2)COc2ccccc2S1(=O)=O

$$$$
SWF000028
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9835    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5003    1.2677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8689   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0841   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000028

>  <SMILES>
CC(C)CCN1[C@H]2CCNCC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF000029
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000029

>  <SMILES>
COc1ccc(-c2nc(C3CCNCC3)cc3c2ncn3C)cc1

$$$$
SWF000030
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000030

>  <SMILES>
O=C(O)c1nc(-c2cn(Cc3ccccc3)cn2)n2ccccc12

$$$$
SWF000031
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000031

>  <SMILES>
O=C1NCCC12CN(Cc1cccnc1)CC21CCNCC1

$$$$
SWF000032
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000032

>  <SMILES>
Cn1cc(-c2cnc(N3CCCC3)nc2)cc1C(=O)NCc1cccnc1

$$$$
SWF000033
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000033

>  <SMILES>
COCCN(C)c1nc(C2CCNCC2)cc2c1ncn2C

$$$$
SWF000034
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
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 30 33  1  0  0  0  0
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M  END
>  <HTSID>
SWF000034

>  <SMILES>
O=S(=O)(Cc1ccccc1)N1CCCC2(CCCN2CC(c2ccccc2)c2ccccc2)C1

$$$$
SWF000035
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000035

>  <SMILES>
O=C(c1ccc2ncccc2c1)N1CCC2(CC1)CC(Nc1nccs1)CO2

$$$$
SWF000036
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000036

>  <SMILES>
CC(=O)N1CCCC2(CCN(C(=O)C3CCCCC3)CC2)C1

$$$$
SWF000037
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000037

>  <SMILES>
CCC(=O)N1CCCC2(COCCN(c3ncccn3)C2)C1

$$$$
SWF000038
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000038

>  <SMILES>
CC(C)C1COC2(CCCN(C(=O)c3ccc(O)cc3)C2)C1

$$$$
SWF000039
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 15 19  2  0  0  0  0
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 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  9 14  1  0  0  0  0
 16 19  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000039

>  <SMILES>
CC(C)N1CCOCC2(CCCN(C(=O)Cc3ccccc3)C2)C1

$$$$
SWF000040
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147    0.6499   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3366    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4839   -2.4456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
 13 11  1  1  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000040

>  <SMILES>
CC(=O)N1C[C@H]2C[C@H]3[C@](C1)(CN(Cc1ccccc1)S3(=O)=O)O2

$$$$
SWF000041
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4560   -4.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7758   -3.8660   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1612   -5.5546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0705   -2.9104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8414   -6.2877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
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 11 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000041

>  <SMILES>
CC(C)N1CCOCC2(CCCN(C(=O)c3cccc(O)c3)C2)C1

$$$$
SWF000042
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000042

>  <SMILES>
O=C(c1ccccc1)N1C[C@@H]2CCN(c3cccnc3)C[C@@H]2C1

$$$$
SWF000043
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  1  0  0  0
 11 16  2  0  0  0  0
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 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000043

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@@H]2OCCN(c3ncccn3)[C@@H]2C1

$$$$
SWF000044
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000044

>  <SMILES>
Cc1ccc(CN2CCC3(CCCN3C(=O)C(C)C)CC2)o1

$$$$
SWF000045
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000045

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCNCC3)c3ccccc32)CC1

$$$$
SWF000046
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.4768    5.4199   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000046

>  <SMILES>
CS(=O)(=O)N1CCN(c2ccc3ccc(C(=O)O)cn23)CC1

$$$$
SWF000047
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000047

>  <SMILES>
CN(C)C(=O)COC1CCC2(CCNCC2)c2ccccc21

$$$$
SWF000048
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000048

>  <SMILES>
CC(C)Nc1nc2c(cc1C(=O)NCC1CC1)CCNCC2

$$$$
SWF000049
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000049

>  <SMILES>
CCCNC(=O)c1ccc2ccc(N3CCN(CCOC)CC3)n2c1

$$$$
SWF000050
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 11  1  1  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000050

>  <SMILES>
CCN1CCOCC2(CCCN(C(=O)c3ccc(F)cc3)C2)C1

$$$$
SWF000051
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000051

>  <SMILES>
O=C(Cc1ccc(Cl)cc1)N1CCC2(CN(Cc3ccccc3Cl)C2)C1

$$$$
SWF000052
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
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 23 24  1  0  0  0  0
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 14 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF000052

>  <SMILES>
CCNC(=O)N1CCC2(C1)c1ccccc1S(=O)(=O)N2CCOC

$$$$
SWF000053
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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 20 23  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000053

>  <SMILES>
CC(=O)N1CCCC2(CCN(C(=O)c3c(C)noc3C)CC2)C1

$$$$
SWF000054
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  CHG  2   2   1   3  -1
M  END
>  <HTSID>
SWF000054

>  <SMILES>
Cc1ccc(CN2CCOC3(CCCN(C)C3)C2)cc1[N+](=O)[O-]

$$$$
SWF000055
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000055

>  <SMILES>
Cc1ccc(CN2CCCC23CCCN(C(=O)Nc2ccccc2)C3)o1

$$$$
SWF000056
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000056

>  <SMILES>
O=C(c1ccncc1)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF000057
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF000057

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CN(S(=O)(=O)Cc2ccccc2)C3)o1

$$$$
SWF000058
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000058

>  <SMILES>
COCCC(=O)N1CC2(CCN(Cc3ccc(O)cc3)CC2)C1

$$$$
SWF000059
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000059

>  <SMILES>
CC(C)CN1CC2CN(C(=O)Cc3ccc(Cl)cc3)CC21

$$$$
SWF000060
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000060

>  <SMILES>
O=S(=O)(c1ccccc1)N1CCCC2(CCCN2Cc2ccc(Cl)cc2)C1

$$$$
SWF000061
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000061

>  <SMILES>
CC(C)C(=O)N1CCC2(CCN(C(=O)c3cscn3)C2)C1

$$$$
SWF000062
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000062

>  <SMILES>
Cn1cc(C2COC3(CCN(C(=O)c4cccnc4)CC3)C2)cn1

$$$$
SWF000063
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000063

>  <SMILES>
c1cncc(CNc2ccc3nc(C4CCNCC4)nn3c2)c1

$$$$
SWF000064
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000064

>  <SMILES>
O=C(O)c1ccnn1-c1ccc2ccc(-c3ccccc3)cn12

$$$$
SWF000065
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000065

>  <SMILES>
CC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(C(=O)c3cnccn3)C[C@H]12

$$$$
SWF000066
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
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 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000066

>  <SMILES>
O=C(N1CCOCC1)[C@]12CCCNC[C@H]1CN(c1ncccn1)C2

$$$$
SWF000067
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4373    1.8283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 16  2  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 12 14  2  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000067

>  <SMILES>
O=C(O)c1ccn(-c2ccc3ccc(-c4ccccc4)cn23)n1

$$$$
SWF000068
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.2406    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5396    4.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4906    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3805    1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4824    2.2172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10 13  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
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 12 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000068

>  <SMILES>
CC(C)CNC(=O)[C@@]12CCC3(CCNCC3)[C@@H]1CN(S(C)(=O)=O)C2

$$$$
SWF000069
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000069

>  <SMILES>
O=C(CC1CC2(CCNCC2)Oc2ccccc21)NCC1CC1

$$$$
SWF000070
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.9010    3.9431   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000070

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(C(=O)Cc1ccccn1)C2

$$$$
SWF000071
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000071

>  <SMILES>
COc1ccc(CCN2C[C@H]3CCNCC[C@H]3S2(=O)=O)cc1

$$$$
SWF000072
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000072

>  <SMILES>
COc1ccc(CNC(=O)c2nc3c(s2)CCNCC3)cc1

$$$$
SWF000073
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 23 24  2  0  0  0  0
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M  END
>  <HTSID>
SWF000073

>  <SMILES>
COc1ccc(-c2nc(-c3noc4ccc(C(=O)O)cc34)cs2)cc1

$$$$
SWF000074
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000074

>  <SMILES>
CC(C)CN1[C@H]2CCNCC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF000075
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000075

>  <SMILES>
CC(C)CNC(=O)CC1CC2(CCNCC2)Oc2ccccc21

$$$$
SWF000076
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000076

>  <SMILES>
CS(=O)(=O)N1CCn2c(-c3ccccc3)cnc2C12CCNCC2

$$$$
SWF000077
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  2  0  0  0  0
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 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8 11  1  0  0  0  0
 14 15  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000077

>  <SMILES>
O=C(CC1CC2(CCNCC2)Oc2ccccc21)NC1CCC1

$$$$
SWF000078
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4673    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 11 13  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000078

>  <SMILES>
CN(C)CCNC(=O)CC1CC2(CCNCC2)c2ccccc21

$$$$
SWF000079
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000079

>  <SMILES>
COc1ccc(NC(=O)c2nc3c(s2)CCNCC3)cc1

$$$$
SWF000080
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 20 24  1  0  0  0  0
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 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000080

>  <SMILES>
COCCN(C)c1nc(C2CCNCC2)cc2c1ncn2C(C)C

$$$$
SWF000081
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000081

>  <SMILES>
COCCNC(=O)CC1CC2(CCNCC2)Oc2ccccc21

$$$$
SWF000082
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000082

>  <SMILES>
CN1CCN(Cc2ccccn2)CC1c1nnc2ccc(C(=O)O)cn12

$$$$
SWF000083
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000083

>  <SMILES>
CN(C)C(=O)CN1CC[C@]2(CNC[C@H]2c2ccccc2)C1=O

$$$$
SWF000084
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 20 24  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000084

>  <SMILES>
CS(=O)(=O)N1C[C@H]2C3(CCNCC3)CC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF000085
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
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 13 16  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000085

>  <SMILES>
c1ccc(CN2CCC(N3CC4CN(Cc5ccccc5)CC43)CC2)cc1

$$$$
SWF000086
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000086

>  <SMILES>
Cc1ccc(CN2CC3CN(S(=O)(=O)c4ccccc4)CC3C2)o1

$$$$
SWF000087
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000087

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CCN(Cc3ccco3)C2)CC1

$$$$
SWF000088
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    3.8971    3.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 11 14  1  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000088

>  <SMILES>
C=CCOCC12CCCOC1CCN(S(=O)(=O)CC)C2

$$$$
SWF000089
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000089

>  <SMILES>
O=C1COC2(CCN(c3ccccn3)CC2)CN1Cc1ccccn1

$$$$
SWF000090
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.6603   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 10 13  1  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000090

>  <SMILES>
CN(C)C(=O)CC1CCC2(CC1)CCN(C(=O)c1ccoc1)CC2

$$$$
SWF000091
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 25 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000091

>  <SMILES>
CCN(Cc1ccccc1)C(=O)c1cc2c(c3ccccc3n2C(C)C)n1C

$$$$
SWF000092
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
 11 16  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000092

>  <SMILES>
CN(Cc1cccnc1)C1CCN(C(=O)c2ccco2)C(C(=O)O)C1

$$$$
SWF000093
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000093

>  <SMILES>
c1cncc(N2CCOCC3(CN(Cc4ccsc4)CCO3)C2)c1

$$$$
SWF000094
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000094

>  <SMILES>
COCC12CCCOC1CCN(Cc1ccc(OC)cc1)C2

$$$$
SWF000095
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000095

>  <SMILES>
Fc1cccnc1OC1C2CCC1N(Cc1cccnc1)CCO2

$$$$
SWF000096
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF000096

>  <SMILES>
c1csc(CN2CCCC3(CC(Nc4cnccn4)CO3)C2)c1

$$$$
SWF000097
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000097

>  <SMILES>
O=C(c1cccnc1)N1CCc2ncnc(N3CCCC3)c2CC1

$$$$
SWF000098
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4560   -4.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000098

>  <SMILES>
CC(=O)N1CCOCC2(C1)CN(C(=O)c1cccnc1)CCO2

$$$$
SWF000099
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000099

>  <SMILES>
Cc1occc1C(=O)N1CCC2(CC(=O)N(c3ccccn3)C2)C1

$$$$
SWF000100
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0691    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000100

>  <SMILES>
CC(C)CN1C[C@H]2CCN(C(=O)Nc3ccccc3)CC[C@H]2S1(=O)=O

$$$$
SWF000101
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -1.8041   -4.0230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 13 10  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000101

>  <SMILES>
O=C1COC2(COCCN(Cc3ccco3)C2)CN1c1ccc(F)cc1

$$$$
SWF000102
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.6043   -0.7518   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  1  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000102

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)N2CCOCC2)[C@H]1Cc1ccccc1

$$$$
SWF000103
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.3792   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8705    1.1363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
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 17 21  1  0  0  0  0
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  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000103

>  <SMILES>
c1ccc(N2CCC3(COCCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF000104
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000104

>  <SMILES>
CC(C)CN1CCc2cc(C(=O)NCC3CC3)c(N(C)C)nc2CC1

$$$$
SWF000105
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0672   -4.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0182   -6.2904   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000105

>  <SMILES>
Cc1nc(CN2C(=O)CC[C@@H]3[C@H]2CCN3C(=O)c2ccoc2)cs1

$$$$
SWF000106
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.8207   -3.5162   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6072   -4.3979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000106

>  <SMILES>
O=C(c1cscn1)N1CCC2(CN(Cc3ccoc3)C2)C1

$$$$
SWF000107
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2473   -4.4975   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1458   -3.5780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2432   -4.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1207   -3.3555   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6073   -2.9201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4658   -3.4330   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8009   -4.0885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4154   -2.3999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5061   -5.0441   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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  8 10  2  0  0  0  0
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 12  9  1  6  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000107

>  <SMILES>
Cc1ccc(N2CC3(COCCN(Cc4ccco4)C3)OCC2=O)s1

$$$$
SWF000108
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    3.7853   -3.1970   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2853   -4.0630   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853   -2.3309   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6  4  1  1  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000108

>  <SMILES>
Cc1nc(CN2C(=O)C[C@@H]3[C@@H]2CCN3S(C)(=O)=O)cs1

$$$$
SWF000109
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000109

>  <SMILES>
Cn1cccc1C(=O)N1CCC2(CC(=O)N(c3ccccn3)C2)C1

$$$$
SWF000110
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5439   -3.4237   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2870   -4.0929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0252   -3.7327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000110

>  <SMILES>
O=C([C@H]1CO[C@@H]2CN(Cc3nccs3)C[C@H]12)N1CCCC1

$$$$
SWF000111
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9841    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7475   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  2  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000111

>  <SMILES>
Cn1cc(CN2CCCC3(CCN(C(=O)c4cccs4)C3)C2)cn1

$$$$
SWF000112
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1525    1.4680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 16 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000112

>  <SMILES>
COCC1c2nnn(CC3CC3)c2CCN1C(=O)c1cnccn1

$$$$
SWF000113
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.3493    2.0658   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8493    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000113

>  <SMILES>
COCCN1CCC2(CCCN(Cc3cccs3)C2)C1=O

$$$$
SWF000114
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  9  1  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000114

>  <SMILES>
CN1CCN(C)C2(CCN(C(=O)c3ccnnc3)CC2)C1=O

$$$$
SWF000115
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3622   -3.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000115

>  <SMILES>
O=C(c1ccsc1)N1CC[C@H]2[C@H]1CCN2Cc1cccnc1

$$$$
SWF000116
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3783    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  9 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  2  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000116

>  <SMILES>
CN(C)[C@@H]1CCN(Cc2cnn(C)c2)[C@H]1Cc1cnn(C)c1

$$$$
SWF000117
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814    4.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1833    5.9672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6915    6.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1870    7.0819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7235    8.5085   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7235   10.9356   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2969   10.4720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000117

>  <SMILES>
COCCNC(=O)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccoc2)O1

$$$$
SWF000118
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685   -3.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4533   -1.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1225   -2.7044   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1006   -2.4965   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8135   -3.6554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4826   -4.3986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4607   -4.1907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 11  1  6  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000118

>  <SMILES>
c1csc(CN2CC[C@@H]3[C@@H](CO[C@H]3CN3CCOCC3)C2)c1

$$$$
SWF000119
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000119

>  <SMILES>
CN(C)C(=O)C[C@@H]1COC[C@H]2CN(Cc3cnn(C)c3)C[C@@H]12

$$$$
SWF000120
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.2720    3.5321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1563    2.3150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6914    0.8843   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6607    2.3150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9085   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2441    0.5839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1256    0.8843   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6057   -0.7522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2113   -0.7522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6057   -2.2566   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3111   -0.0823   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -2.2566   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -6.7697   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3028   -7.5219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  7  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000120

>  <SMILES>
CC[C@@H]1N(C(=O)c2ccccn2)CCC[C@]12CCC(=O)N2C

$$$$
SWF000121
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000121

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@H]2OCC[C@H]2N(C(=O)c2ccoc2)C1

$$$$
SWF000122
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    8.7865   -2.7227   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2354   -3.1109   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5907   -4.2099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3862   -1.3369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4007   -5.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9765   -4.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8734    1.0654   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1723   -6.2710   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  1  0  0  0  0
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 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000122

>  <SMILES>
CCN1CC2(CCN(Cc3ccccn3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF000123
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3481   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  7 10  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000123

>  <SMILES>
C=CCN1C(=O)CCCC12CCCN(C(=O)c1ccoc1)C2

$$$$
SWF000124
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000124

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CC(=O)N(c3ccccn3)C2)C1

$$$$
SWF000125
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000125

>  <SMILES>
O=C(NCc1cccnc1)C1=NOC2(CCCN(C(=O)C3CCCC3)C2)C1

$$$$
SWF000126
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5100    5.1478   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000126

>  <SMILES>
O=C(Nc1cccnc1)c1noc2c1CN(S(=O)(=O)C1CC1)CC2

$$$$
SWF000127
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.2592   -7.5661   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7013   -6.1328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 22 25  1  0  0  0  0
  7 10  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000127

>  <SMILES>
Cn1ccnc1CN1CCOCC2(C1)CN(c1ccoc1)C(=O)CO2

$$$$
SWF000128
Actelion Java MolfileCreator 1.0

 20 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  2  0  0  0  0
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 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000128

>  <SMILES>
O=S(=O)(C1CC1)N1CC2(CCN(Cc3ccsc3)C2)C1

$$$$
SWF000129
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    7.5516    3.1160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
M  END
>  <HTSID>
SWF000129

>  <SMILES>
COCCN1C(=O)CCC12CCN(C(=O)CNC(C)=O)CC2

$$$$
SWF000130
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000130

>  <SMILES>
O=C(c1ccoc1)N1CCC2(CC1)CN(Cc1ccccn1)CCO2

$$$$
SWF000131
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.8570   -4.5750   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9168   -3.5768   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8112   -3.1295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0822   -3.0259   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7962   -2.1296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0374   -2.0269   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0734   -1.7609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4775   -2.5955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
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 13 16  1  0  0  0  0
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 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF000131

>  <SMILES>
CC(=O)N(C)Cc1ncn2c1CN(C(=O)C1CCCO1)CCC2

$$$$
SWF000132
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3147   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000132

>  <SMILES>
O=C(c1ccncc1)N1CCN2C[C@H](Oc3cccnc3)C[C@H]2C1

$$$$
SWF000133
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0159   -4.7893   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2811   -7.8348   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000133

>  <SMILES>
Cc1cccc(CN2C(=O)CCC23CCN(C(=O)c2ccco2)CC3)c1

$$$$
SWF000134
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    3.1906   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 15  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000134

>  <SMILES>
O=C(c1ccccc1)N1CCO[C@@H]2CN(c3cnccn3)C[C@@H]2C1

$$$$
SWF000135
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8255    1.1637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000135

>  <SMILES>
CS(=O)(=O)N1CCCC12CCCN(C(=O)c1ccnnc1)C2

$$$$
SWF000136
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1237   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7418   -4.5556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0508   -5.5067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4109   -3.8125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6981   -4.9714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000136

>  <SMILES>
Cc1nnc(C[C@@H]2OC[C@H]3CN(Cc4cccnc4)CC[C@H]32)[nH]1

$$$$
SWF000137
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.3949   -0.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  6  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000137

>  <SMILES>
O=C([C@H]1CO[C@@H]2CN(Cc3ccco3)C[C@H]12)N1CCCCO1

$$$$
SWF000138
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2382   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000138

>  <SMILES>
CN1CC2(CCN(Cc3cccnc3)CC2)CC1COCC1CC1

$$$$
SWF000139
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000139

>  <SMILES>
Cn1cccc1C(=O)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF000140
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.1718   -0.4108   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 12  2  0  0  0  0
 13 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000140

>  <SMILES>
Cc1ccc2c(n1)N(CCN(C)C)CCN(C(=O)c1ccco1)C2

$$$$
SWF000141
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000141

>  <SMILES>
COCCN1CCC2(CCN(C(=O)c3ccncc3)CC2)C1=O

$$$$
SWF000142
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000142

>  <SMILES>
CS(=O)(=O)NCc1ncn2c1CN(C(=O)c1ccsc1)CCC2

$$$$
SWF000143
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000143

>  <SMILES>
O=C(c1ccoc1)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF000144
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962    6.5961   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000144

>  <SMILES>
O=C(c1cscn1)N1C[C@@H]2COC[C@]2(COc2ccccn2)C1

$$$$
SWF000145
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.9442   -6.2592   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2432   -4.0092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.5423   -4.7592   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000145

>  <SMILES>
Cn1cc(CN2CCC3(CC(=O)N(c4ccc(F)c(F)c4)C3)C2)cn1

$$$$
SWF000146
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 13  1  0  0  0  0
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 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000146

>  <SMILES>
Cn1cc(CN2CC[C@H]3O[C@H](C(=O)NCC4CC4)CC[C@H]32)cn1

$$$$
SWF000147
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000147

>  <SMILES>
Cc1cc(CN2CC[C@]3(C[C@@H](OCC(=O)N(C)C)CO3)C2)no1

$$$$
SWF000148
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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   11.1761    2.1085   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
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 18 21  1  6  0  0  0
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 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 26 29  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000148

>  <SMILES>
CCN1C[C@H]2C3(CCN(S(=O)(=O)c4ccccc4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF000149
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.9844   -1.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9782   -0.1402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
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 18 20  1  0  0  0  0
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 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000149

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)c2ccsc2)[C@H]1Cc1ccncc1

$$$$
SWF000150
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000150

>  <SMILES>
Cc1cccc(CN2CCCC3(CC(OCC4CC4)CO3)C2)n1

$$$$
SWF000151
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.3923   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 14 16  1  0  0  0  0
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 21 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF000151

>  <SMILES>
CN(C)C(=O)NCc1cc(=O)n2c(n1)CN(C1CCOCC1)CCC2

$$$$
SWF000152
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000152

>  <SMILES>
CS(=O)(=O)N1CC[C@H]2[C@@H]1CCC(=O)N2CCN1CCCC1

$$$$
SWF000153
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 20 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF000153

>  <SMILES>
O=C(CCOc1ccccc1)N1CC[C@]2(C[C@@H](OCC3CC3)CO2)C1

$$$$
SWF000154
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.0734   -1.7609   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF000154

>  <SMILES>
CC(C)N(C)Cc1ncn2c1CN(C(=O)c1cscn1)CCC2

$$$$
SWF000155
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000155

>  <SMILES>
C=CCOC[C@H]1CC[C@H]2[C@H](CCN2Cc2c(C)noc2C)O1

$$$$
SWF000156
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  2  0  0  0  0
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  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000156

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)Cc1ccccc1CNC2=O

$$$$
SWF000157
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 21 23  2  0  0  0  0
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 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000157

>  <SMILES>
CO[C@@H]1CCN(C(=O)C2CC2)[C@@H]2CN(Cc3cccnc3)C[C@@H]21

$$$$
SWF000158
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000158

>  <SMILES>
O=C(c1ccncc1)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF000159
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000159

>  <SMILES>
C[C@H]1CN(Cc2ccncc2)C[C@@]12CCN(CCN(C)C)C2=O

$$$$
SWF000160
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.5782   -0.5296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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 12 10  1  6  0  0  0
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 14 16  1  0  0  0  0
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 17 18  1  1  0  0  0
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 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000160

>  <SMILES>
Cc1noc(C)c1CN1CC[C@]2(C[C@@H](OCC3CC3)CO2)C1

$$$$
SWF000161
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000161

>  <SMILES>
O=C1CC(c2ccncc2)C2(CCN(Cc3ccoc3)CC2)N1

$$$$
SWF000162
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
   11.1761    2.1085   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  6  0  0  0
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 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000162

>  <SMILES>
CN1C[C@H]2C3(CCN(C(=O)c4cccnc4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF000163
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -1.3411    1.9182   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000163

>  <SMILES>
Cc1cncc(C(=O)N2CCCn3cnc(CN4CCCC4=O)c3C2)c1

$$$$
SWF000164
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    3.8374    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000164

>  <SMILES>
CCN1[C@H]2CCN(C)CC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF000165
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000165

>  <SMILES>
Cn1cc(CN2C[C@H]3C[C@@H](C(=O)NC4CCC4)C[C@H]3C2)cn1

$$$$
SWF000166
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000166

>  <SMILES>
CN(C)CC1COC2(COCCN(Cc3cccs3)C2)C1

$$$$
SWF000167
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000167

>  <SMILES>
CNC(=O)N1CCc2cc(C(=O)N(C)C)c(NC(C)C)nc2CC1

$$$$
SWF000168
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000168

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(Cc3ccco3)CC[C@H]21)N1CCCCO1

$$$$
SWF000169
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4553   -1.0311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7701   -3.9500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.7419   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0409   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4112   -4.1572   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1977   -2.0553   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4149   -3.0425   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6649   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000169

>  <SMILES>
CCN1C[C@H]2CCN(C(=O)c3cc[nH]n3)CC[C@H]2S1(=O)=O

$$$$
SWF000170
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.1734    2.3368   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2909    1.3306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9782   -0.1402   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7210    1.7953   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6045   -0.7519   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9844   -1.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9375    0.9114   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    3.2254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7617   -2.2473   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3023   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2326   -2.5600   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1541    1.7953   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6894    3.2254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3023    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6045   -2.2556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000170

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)[C@H]2CCCO2)[C@H]1Cc1ccccc1

$$$$
SWF000171
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.5300    3.4297   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5355    3.5343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1287    4.4478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9477    2.7253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5464    3.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000171

>  <SMILES>
O=C(O)CN1CCCC2(CC(Nc3ncc(F)cn3)CO2)C1

$$$$
SWF000172
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    6.0413   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856   -0.1151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -3.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0686   -3.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1140   -7.0381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000172

>  <SMILES>
CN1C(=O)[C@H]2CN(c3ncccn3)C[C@H]2C12CCN(C(=O)c1ccncc1)CC2

$$$$
SWF000173
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  9 11  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000173

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCN(Cc2ccco2)[C@H]1Cc1ccccc1

$$$$
SWF000174
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000174

>  <SMILES>
Cc1cccc(C(=O)N2CC[C@@H]3[C@H]2CCC(=O)N3CC2CC2)n1

$$$$
SWF000175
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 11  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000175

>  <SMILES>
O=C([C@H]1C[C@H]2OCC[C@H]2N(Cc2ccccn2)C1)N1CCCO1

$$$$
SWF000176
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   12.9904   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000176

>  <SMILES>
COCC(=O)N1CCC2(CC1)CCN(C(=O)c1cnccn1)CC2

$$$$
SWF000177
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.5077    3.1532   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 12 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000177

>  <SMILES>
Cc1ccc(C(=O)N2CCOCC3(CCC(CN(C)C)O3)C2)cn1

$$$$
SWF000178
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000178

>  <SMILES>
Cc1noc([C@@H]2CNC(=O)[C@@H]3CCN(C4CCOC4)CC[C@@H]32)n1

$$$$
SWF000179
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 14 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000179

>  <SMILES>
CNC(=O)CN1CC2(CCNCC2)COc2ccccc2S1(=O)=O

$$$$
SWF000180
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000180

>  <SMILES>
O=C(c1ccncc1)N1CCc2ncnc(N3CCCC3)c2CC1

$$$$
SWF000181
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000181

>  <SMILES>
O=C(NCC1CCC2C1OCCN2Cc1ccoc1)c1ccnnc1

$$$$
SWF000182
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.0468   -4.3005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000182

>  <SMILES>
O=C(c1ccoc1)N1CCOC2CC(COCc3cccnc3)CC21

$$$$
SWF000183
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 15  1  1  0  0  0
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 13 17  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000183

>  <SMILES>
CCOCC1CN(C(=O)C2CCOCC2)Cc2cnn(C)c21

$$$$
SWF000184
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000184

>  <SMILES>
CC(C)NC(=O)N1CCC2(CC2C(=O)NCc2cccnc2)C1

$$$$
SWF000185
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000185

>  <SMILES>
O=C(c1ccoc1)N1CCC2(CN(Cc3ccc(F)cc3)C2)C1

$$$$
SWF000186
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.8660   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  7  1  1  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000186

>  <SMILES>
O=C1CO[C@@H]2CN(c3ncccn3)C[C@H]2N1Cc1ccncc1

$$$$
SWF000187
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000187

>  <SMILES>
CN(C)C(=O)N1CCC2(CCCN(C(=O)c3cnccn3)C2)C1

$$$$
SWF000188
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    9.4842    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000188

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccncc3)CC2)c2ccccc21)NCC1CC1

$$$$
SWF000189
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 12 14  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000189

>  <SMILES>
CCS(=O)(=O)N[C@@H]1CN(Cc2ccco2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF000190
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.4490   -2.9888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000190

>  <SMILES>
c1cncc(CN2CCO[C@@H]3CN(Cc4ccncc4)CC[C@@H]3C2)c1

$$$$
SWF000191
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000191

>  <SMILES>
Cc1ccc2c(c1)C1(CC2)CCN(Cc2ccc(C)s2)CC1

$$$$
SWF000192
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000192

>  <SMILES>
c1ccc(COC2COC3(CCN(CC4CC4)CC3)C2)cc1

$$$$
SWF000193
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000193

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CCN(Cc3ccoc3)CC2)C1

$$$$
SWF000194
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF000194

>  <SMILES>
O=C1N(c2cncnc2)CCC12CCCN(Cc1cccs1)C2

$$$$
SWF000195
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000195

>  <SMILES>
c1cc(CO[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2ccoc2)ccn1

$$$$
SWF000196
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -1.7796    0.5933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000196

>  <SMILES>
C=CCN1C(=O)CCCC12CCCN(Cc1nccs1)C2

$$$$
SWF000197
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 18 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000197

>  <SMILES>
O=C1CCCN1[C@@H]1CN(Cc2nccs2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF000198
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000198

>  <SMILES>
C=CCN1C(=O)CCCC12CCCN(Cc1ccc(C)o1)C2

$$$$
SWF000199
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1224    1.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113    0.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903   -1.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.7686   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3115   -3.1902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812   -2.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000199

>  <SMILES>
c1cnc(N2CCOCC3(CCCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF000200
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000200

>  <SMILES>
c1csc(CN2CCC3(CC2)CCN(CC2CC2)CC3)c1

$$$$
SWF000201
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    4.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6261    3.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    4.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000201

>  <SMILES>
Cc1oncc1C(=O)N1CCC2OCCCC2(COc2ccccn2)C1

$$$$
SWF000202
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.5502   -0.4225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 13 11  1  1  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000202

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(Cc4ccccc4F)C[C@@H]32)C(=O)N1C

$$$$
SWF000203
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  1  0  0  0  0
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  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 11 10  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  8  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000203

>  <SMILES>
Cn1cc(CN2CC[C@@H]3[C@@H](CCN3C(=O)c3cccc(F)c3)C2)cn1

$$$$
SWF000204
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9835    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 13  1  1  0  0  0
 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000204

>  <SMILES>
COCCN1[C@H]2CCN(Cc3ccccc3)CC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF000205
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000205

>  <SMILES>
O=C1N(Cc2ccncc2)CCC12CCCN(S(=O)(=O)C1CC1)C2

$$$$
SWF000206
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000206

>  <SMILES>
Cc1cc(C(=O)N2CCCC3(CCCN3Cc3cccnc3)C2)[nH]n1

$$$$
SWF000207
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   12.6556    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.9272   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3171   -3.3681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4190   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4518   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1988   -4.5816   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.3007   -3.0545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6905   -4.4248   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000207

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)c3ccnnc3)CC2)C1

$$$$
SWF000208
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2556    0.8638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 15  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000208

>  <SMILES>
O=C(C1CN(Cc2ccccn2)CC12CCOCC2)N1CCOCC1

$$$$
SWF000209
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000209

>  <SMILES>
Cc1nc(CN2CCC3(CCCN(c4ccccn4)C3)C2=O)cs1

$$$$
SWF000210
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.0820    2.2205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000210

>  <SMILES>
CC(C)CN1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF000211
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.3660    5.5388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000211

>  <SMILES>
O=C(NC1CCCC1)[C@H]1CCO[C@H]2CCN(Cc3ccsc3)C[C@@H]21

$$$$
SWF000212
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9814   -1.1970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000212

>  <SMILES>
COCCN1C(=O)C[C@H]2[C@H]1CCN2Cc1ccc(OC)cc1

$$$$
SWF000213
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2708   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3188   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8188   -4.3415   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8188   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5688   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
 22 26  1  0  0  0  0
 24 27  1  0  0  0  0
 24 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  2  0  0  0  0
 20 21  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF000213

>  <SMILES>
CCc1ccc(S(=O)(=O)N2CCc3nc(N4CCOCC4)nc(N(C)C)c3CC2)cc1

$$$$
SWF000214
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.6497    2.0209   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4498    1.4210   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3304    0.4282   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3694    1.8141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3841    0.1050   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1732   -0.1102   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1695    1.2142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4888    2.8069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2777   -1.1047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0890    1.6073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4083    3.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5725   -1.6871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5653   -1.8065   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2084    2.6001   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 12 17  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000214

>  <SMILES>
COCCN1CCC2(COCCN(C(=O)c3ccccn3)C2)C1

$$$$
SWF000215
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.6211    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3121    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9812   -0.2127   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0323   -2.8579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3195   -1.6990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9886   -2.4421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000215

>  <SMILES>
COCCN1CC[C@H]2O[C@@H](C(=O)NCc3cccnc3)CC[C@H]21

$$$$
SWF000216
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    6.4408   -2.1748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0537   -0.7981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5277   -0.4848   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3002    0.5070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5468    1.8120   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3575    1.5631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0808   -1.0275   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9476    2.0970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6610    3.0312   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9152   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3051   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8843    6.0996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4998    7.1612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1127    8.5379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0011    7.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000216

>  <SMILES>
CCN1CCC2(CN(C(=O)N(C)C)CC23CCN(C(=O)c2ccccc2)CC3)C1=O

$$$$
SWF000217
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  8  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000217

>  <SMILES>
O=C(c1cccc(F)c1)N1CCC2CN(Cc3ccncc3)CC21

$$$$
SWF000218
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000218

>  <SMILES>
O=C(c1ccoc1)N1CC2(CCN(Cc3ccsc3)C2)C1

$$$$
SWF000219
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000219

>  <SMILES>
CS(=O)(=O)NCCC1CCOC12CN(Cc1cccnc1)C2

$$$$
SWF000220
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 29 31  2  0  0  0  0
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 13 15  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF000220

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(Cc4cccnc4)CC3)c3ccccc32)CC1

$$$$
SWF000221
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 31 33  1  0  0  0  0
M  END
>  <HTSID>
SWF000221

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(C(=O)c4cccn4C)CC3)O2)c1

$$$$
SWF000222
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 14 18  2  0  0  0  0
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 17 20  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000222

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(Cc4ccco4)C3)C2=O)n1

$$$$
SWF000223
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.9684   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.9906   -7.4519   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000223

>  <SMILES>
Fc1ccc(CN2CCC3(CCN(Cc4nccs4)CC3)C2)cc1

$$$$
SWF000224
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3147   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  9  1  6  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000224

>  <SMILES>
O=C1[C@H]2CN(Cc3ccncc3)C[C@@H]2CCN1Cc1cccnc1

$$$$
SWF000225
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2875   -4.0682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6414   -0.1055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0174   -1.9091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.4022   -5.0719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000225

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@@H]2[C@@H](CNc3ccccn3)CO[C@@H]2C1

$$$$
SWF000226
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.8549    1.6691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
  9 11  1  0  0  0  0
 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000226

>  <SMILES>
c1ccc(CCN2CC[C@@H](OCc3ccccn3)[C@H]3OCC[C@@H]32)cc1

$$$$
SWF000227
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  6  0  0  0
 11 13  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000227

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF000228
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.5527   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5308   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2000   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8910    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0562    4.5430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000228

>  <SMILES>
CN(C)CCO[C@H]1CN(Cc2cccnc2)[C@@H]2CCCO[C@H]12

$$$$
SWF000229
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2748    1.6193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9442    3.2592   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2432    4.0092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6452    4.0092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2432    5.5092   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6452    5.5092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000229

>  <SMILES>
CN(C)S(=O)(=O)N1CC[C@]2(C[C@@H](Oc3cccnc3)CO2)C1

$$$$
SWF000230
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8676    1.0569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2212   -3.3187   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000230

>  <SMILES>
Fc1cccnc1OC1C2CCC1N(C1CCOCC1)CCO2

$$$$
SWF000231
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000231

>  <SMILES>
CC(=O)N1CCCCC12CCCN(C(=O)c1ccccn1)C2

$$$$
SWF000232
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.5372   -4.9182   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106   -5.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1471   -6.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000232

>  <SMILES>
O=C1CCCN1[C@@H]1CN(Cc2ccccn2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF000233
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 18  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000233

>  <SMILES>
COC[C@]12COC[C@H]1CN(C(=O)c1ccc3ccccc3n1)C2

$$$$
SWF000234
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.8531   -0.1872   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 10 14  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000234

>  <SMILES>
CC(=O)N1CCC2(CC1)[C@@H]1CN(CC(C)C)C[C@@H]1C(=O)N2C

$$$$
SWF000235
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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 13 19  1  0  0  0  0
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 25 30  2  0  0  0  0
 29 31  2  0  0  0  0
 12 13  2  0  0  0  0
 19 24  1  0  0  0  0
 21 27  1  0  0  0  0
 23 28  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF000235

>  <SMILES>
CCN(Cc1ccccc1)C(=O)c1cc2c(c3ccccc3n2C)n1-c1ncccn1

$$$$
SWF000236
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7734   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000236

>  <SMILES>
COCC(=O)N1CCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF000237
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.8411    4.4196   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5428    4.5005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000237

>  <SMILES>
CN(C)CC1CCC2(COCCN(Cc3cccnc3)C2)O1

$$$$
SWF000238
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.9952    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000238

>  <SMILES>
OCCN1CCC(F)(F)C2(CCN(Cc3ccccn3)C2)C1

$$$$
SWF000239
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  6  0  0  0
 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000239

>  <SMILES>
Cn1nnc2c1C(COCc1ccccn1)CN(Cc1ccco1)C2

$$$$
SWF000240
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 21 24  2  0  0  0  0
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 25 26  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000240

>  <SMILES>
COCCN1C(=O)C2(CCN(Cc3ccc(C)s3)CC2)c2ccccc21

$$$$
SWF000241
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
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 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000241

>  <SMILES>
Cc1ccc(-c2cnc3n2CCN(C)C32CCN(Cc3ccc(F)cc3)CC2)cc1

$$$$
SWF000242
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 17 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF000242

>  <SMILES>
COCCn1c(C(=O)Nc2cccc(C)c2)cc2c1c1ccccc1n2C(C)C

$$$$
SWF000243
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000243

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(Cc1cnn(C)c1)CC2

$$$$
SWF000244
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF000244

>  <SMILES>
c1cncc(CN2CCCC23CCN(Cc2ccoc2)CC3)c1

$$$$
SWF000245
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000245

>  <SMILES>
COc1ccc(CNC(=O)C2Cn3ccnc3C3(CCN(Cc4ccco4)CC3)O2)cc1

$$$$
SWF000246
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000246

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(Cc4ccoc4)CC3)O2)c1

$$$$
SWF000247
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
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 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF000247

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(Cc4cccnc4)CC3)O2)c1

$$$$
SWF000248
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000248

>  <SMILES>
O=C([C@@H]1COC[C@H]2CN(Cc3cccs3)C[C@H]21)N1CCOCC1

$$$$
SWF000249
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.5492   -1.0986   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000249

>  <SMILES>
COCC1CC2(CCN(Cc3ccc(C)s3)CC2)CN1C

$$$$
SWF000250
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000250

>  <SMILES>
CN(Cc1ccccn1)C1COC2(CCN(Cc3ccco3)CC2)C1

$$$$
SWF000251
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000251

>  <SMILES>
O=C(N1CCOCC1)[C@@]12CCO[C@@H]1CCN(C1CCCCC1)C2

$$$$
SWF000252
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000252

>  <SMILES>
Cc1cc(C(=O)N2CCCC3(CC(C(=O)Nc4ccccc4)=NO3)C2)c(C)o1

$$$$
SWF000253
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000253

>  <SMILES>
c1coc(CN2CCC3(CC2)CCN(Cc2cccs2)CC3)c1

$$$$
SWF000254
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4778    3.3431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000254

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(C(=O)c3cnccn3)CC2)O1

$$$$
SWF000255
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6713    0.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  6  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF000255

>  <SMILES>
CN(C)CCOCC1CN(C(=O)N(C)C)Cc2nnn(C)c21

$$$$
SWF000256
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.6808   -3.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000256

>  <SMILES>
c1cc(-c2ccc3nc(C4CCN(Cc5ccoc5)CC4)nn3c2)ccn1

$$$$
SWF000257
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.8976    0.6423   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3185   -1.6570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000257

>  <SMILES>
c1ccc(CN2CCOCC3(CCC(CN4CCCC4)O3)C2)nc1

$$$$
SWF000258
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 13 16  1  0  0  0  0
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  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000258

>  <SMILES>
O=C(c1ccoc1)N1CCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF000259
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000259

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4ccccn4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF000260
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000260

>  <SMILES>
c1ccc(-c2ccc3nc(C4CCN(Cc5nccs5)CC4)nn3c2)cc1

$$$$
SWF000261
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000261

>  <SMILES>
CCN1CCC2(CN(C(C)=O)CC23CCN(Cc2cccnc2)CC3)C1=O

$$$$
SWF000262
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000262

>  <SMILES>
c1cc(CN2CCC3(CC2)CC(N2CCCC2)CO3)cs1

$$$$
SWF000263
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.0345   -6.0690   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 18 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <HTSID>
SWF000263

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(Cc1nccs1)C2

$$$$
SWF000264
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000264

>  <SMILES>
c1ccc(CN2CCCC3(CCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF000265
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000265

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(C(=O)c2cscn2)CC3)o1

$$$$
SWF000266
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000266

>  <SMILES>
Fc1cccc(CN2CCC3(CCN(Cc4cccnc4)CC3)CC2)c1

$$$$
SWF000267
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  6  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  1  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 25 26  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000267

>  <SMILES>
Cc1cc(CN2CC[C@@]3(C[C@H](NC(=O)c4cnccn4)CCO3)C2)no1

$$$$
SWF000268
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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    9.6248   -8.1572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
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 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF000268

>  <SMILES>
Cc1noc([C@H]2C[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3O2)n1

$$$$
SWF000269
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6891    4.1215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000269

>  <SMILES>
Cc1occc1C(=O)N1CCO[C@H]2[C@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF000270
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4291    0.6401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2952    0.1401   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0383    0.8092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
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 10 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000270

>  <SMILES>
O=C(c1ccoc1)N1CCO[C@H]2[C@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF000271
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.8092    0.1341   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0172    1.1123   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1511    1.6123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4080    0.9432   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0466    2.6068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  2  0  0  0  0
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  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000271

>  <SMILES>
COc1ncccc1CN1C[C@@H]2COC[C@]2(c2nc(C)no2)C1

$$$$
SWF000272
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.5614    2.1132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  2  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000272

>  <SMILES>
c1ccc(CN2CCCC3(CCN(Cc4ccoc4)C3)C2)nc1

$$$$
SWF000273
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.6710   -7.0997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000273

>  <SMILES>
Fc1cnc(NC2COC3(CCCN(CC4CC4)C3)C2)nc1

$$$$
SWF000274
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3370   -5.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2624   -5.5287   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000274

>  <SMILES>
CN1C[C@H]2C3(CCN(C(=O)N(C)C)CC3)CC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF000275
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.2478    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2423    2.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6491    3.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6436    3.3659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613    4.0704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0503    4.2795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4680    4.9840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4626    5.0885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000275

>  <SMILES>
CN(C)C(=O)CN1CCCCC12CCN(C(=O)c1ccccc1)C2

$$$$
SWF000276
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.5793   -2.0773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6273    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2511    3.9627   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8245    3.4992   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7098    4.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8315    5.0430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0287    2.5721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6344    7.5140   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5700    3.1123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  1  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000276

>  <SMILES>
COCC1C(=O)NCC12CCN(Cc1cccnc1OC)CC2

$$$$
SWF000277
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   12.8238   -1.6480   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9806   -3.1397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6066   -2.6351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6103   -3.7498   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1148   -2.7919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000277

>  <SMILES>
Cc1ncsc1CN1CCC2(CC1)COC(COc1cccnc1)C2

$$$$
SWF000278
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
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  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000278

>  <SMILES>
Cn1cc(N2CCC3(CCCN(Cc4ccoc4)C3)C2=O)cn1

$$$$
SWF000279
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000279

>  <SMILES>
c1cncc(CO[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2ccco2)c1

$$$$
SWF000280
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 14 11  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  1  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000280

>  <SMILES>
O=C([C@H]1C[C@H]2OCC[C@H]2N(Cc2ccoc2)C1)N1CCCCO1

$$$$
SWF000281
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000281

>  <SMILES>
Cc1noc([C@H]2C[C@@H]3CCN(Cc4ccc(C)s4)C[C@H]3O2)n1

$$$$
SWF000282
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.6792   -6.7909   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  6  0  0  0
 18 21  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000282

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(Cc3ccsc3)CC2)c2ccccc21

$$$$
SWF000283
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000283

>  <SMILES>
CN(c1ncccn1)C1COC2(CCCN(Cc3ccsc3)C2)C1

$$$$
SWF000284
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000284

>  <SMILES>
CC(=O)N1CC[C@@]2(C[C@H](NS(=O)(=O)C3CC3)CCO2)C1

$$$$
SWF000285
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000285

>  <SMILES>
COc1ccc(CN2CCC3(CC2)CC(CC(=O)NC2CCC2)c2ccccc2O3)cc1

$$$$
SWF000286
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000286

>  <SMILES>
Cc1cccc(COC[C@]23COC[C@H]2CN(Cc2ccccn2)C3)n1

$$$$
SWF000287
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000287

>  <SMILES>
COCCN1CC[C@H]2CN(Cc3ccc(OC)cc3)C[C@@H]2C1=O

$$$$
SWF000288
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000288

>  <SMILES>
CO[C@H]1CCN(Cc2ccsc2)[C@@H]2CN(Cc3ccncc3)C[C@H]12

$$$$
SWF000289
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000289

>  <SMILES>
Cn1cccc1C(=O)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF000290
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.4490   -2.9888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000290

>  <SMILES>
c1cc(CN2CCO[C@@H]3CN(Cc4ccncc4)CC[C@@H]3C2)ccn1

$$$$
SWF000291
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000291

>  <SMILES>
Fc1cccc(NC2COC3(CCN(Cc4ccsc4)C3)C2)c1

$$$$
SWF000292
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
   10.3923   -2.2500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000292

>  <SMILES>
C=CCN1CCN(C)C2(CCN(S(C)(=O)=O)CC2)C1=O

$$$$
SWF000293
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000293

>  <SMILES>
Cn1cc(CN2Cc3cncn3CC(COCC3CCC3)C2)cn1

$$$$
SWF000294
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000294

>  <SMILES>
O=C(C1CN(Cc2ccccn2)CC12CCOCC2)N1CCCC1

$$$$
SWF000295
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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   -2.0456   -4.4836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 12 14  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000295

>  <SMILES>
CN1CCC2(c3ccccc3)CCN(C(=O)c3cccs3)CC12

$$$$
SWF000296
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000296

>  <SMILES>
Cc1ccnc(OC[C@@]23CCO[C@@H]2CCN(C(=O)c2cocn2)C3)n1

$$$$
SWF000297
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 22  1  0  0  0  0
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 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
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 28 30  2  0  0  0  0
 29 31  1  0  0  0  0
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 31 33  1  0  0  0  0
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 18 20  1  0  0  0  0
 21 22  2  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <HTSID>
SWF000297

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(C(=O)c4ccoc4)CC3)O2)c1

$$$$
SWF000298
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000298

>  <SMILES>
Cn1cccc1C(=O)N1CC2CN(Cc3ccccn3)CC2C1

$$$$
SWF000299
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000299

>  <SMILES>
CS(=O)(=O)NC1COCCC12CCN(CCc1ccccc1)CC2

$$$$
SWF000300
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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 11 14  1  0  0  0  0
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 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000300

>  <SMILES>
Fc1ccc(CN2CC[C@H]3[C@H]2CCN3Cc2cccnc2)cc1

$$$$
SWF000301
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000301

>  <SMILES>
CCN1CCc2cc(C(=O)N3CCCC3)c(N(C)C)nc2CC1

$$$$
SWF000302
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10  6  1  6  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000302

>  <SMILES>
CN(C)C(=O)N1C[C@@H]2COC[C@]2(COCc2ccccn2)C1

$$$$
SWF000303
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.3955    4.9136   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000303

>  <SMILES>
CC(C)CN1CCC2(CCN(Cc3nccs3)CC2)C1=O

$$$$
SWF000304
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  7  1  1  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000304

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(Cc3ccc(OC)cc3)C[C@H]2N1C

$$$$
SWF000305
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    0.0681    1.5068   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0463    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 21  2  0  0  0  0
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 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000305

>  <SMILES>
C=CCOC[C@@H]1CCC[C@@]12CN(Cc1nccs1)CCO2

$$$$
SWF000306
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000306

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccccc1)C2)c1ccco1

$$$$
SWF000307
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  8  9  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000307

>  <SMILES>
CC(C)CCC(=O)N1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF000308
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0314   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000308

>  <SMILES>
Fc1cccc(CN2CC3CN(Cc4ccoc4)CC3C2)c1

$$$$
SWF000309
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2759   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000309

>  <SMILES>
O=C(c1cnccn1)N1CC2CN(c3ccccc3)C(=O)C2C1

$$$$
SWF000310
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000310

>  <SMILES>
CN(C)CCN1C(=O)CC[C@@H]2[C@@H]1CCN2Cc1cnn(C)c1

$$$$
SWF000311
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.1710    2.3350   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2876    1.3296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1705   -2.2260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3727   -0.1401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6268   -2.5580   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3781   -1.2568   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8724   -1.0997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000311

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)c2ccccn2)[C@H]1Cc1cnn(C)c1

$$$$
SWF000312
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.3740   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1240   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.8740   -6.4508   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000312

>  <SMILES>
O=C(c1cnccn1)N1CC[C@@H]2CN(Cc3ccsc3)C[C@@H]2C1

$$$$
SWF000313
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3290   -2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3364    0.1927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7963   -2.3486   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8000   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2211    3.3308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9495    5.9146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9110    8.6199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 12 14  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000313

>  <SMILES>
O=C(CC1CC2(CCN(CC3CC3)CC2)c2ccccc21)NCC1CC1

$$$$
SWF000314
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0671   -3.0544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6604   -3.9679   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000314

>  <SMILES>
O=C1N(Cc2ccncc2)CCC12CCCN(c1ncccn1)C2

$$$$
SWF000315
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000315

>  <SMILES>
O=C1COC2(CCN(Cc3ccoc3)CC2)CN1c1ccccc1

$$$$
SWF000316
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000316

>  <SMILES>
c1cnc(N2CCOC3CCC2C3OCc2cccnc2)nc1

$$$$
SWF000317
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2226    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000317

>  <SMILES>
CN(C)C(=O)CO[C@@H]1CC[C@H]2[C@H]1OCCN2Cc1cnn(C)c1

$$$$
SWF000318
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000318

>  <SMILES>
CO[C@@H]1CCN(Cc2nccs2)C[C@@H]1Cc1ccccc1

$$$$
SWF000319
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4560   -4.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7758   -3.8660   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1612   -5.5546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0705   -2.9104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1863   -5.7771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8414   -6.2877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1207   -3.3555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000319

>  <SMILES>
CCN1CCOCC2(CCCN(C(=O)c3ccccn3)C2)C1

$$$$
SWF000320
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4371    0.3907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2506    2.2178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8329    1.5133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000320

>  <SMILES>
COCCN1CCC2(CCN(C(=O)c3cccc(C)n3)CC2)C1=O

$$$$
SWF000321
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2551    3.5204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6078    4.0556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
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  6 11  1  0  0  0  0
  9 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000321

>  <SMILES>
CN(C)C(=O)N1CCO[C@H]2[C@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF000322
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -4.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000322

>  <SMILES>
O=C(c1cnccn1)N1CC2CN(Cc3cccnc3)CC2C1

$$$$
SWF000323
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
 13  9  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 13  1  0  0  0  0
 16 17  2  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000323

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@H]2OCC[C@H]2N(CC2CC2)C1

$$$$
SWF000324
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000324

>  <SMILES>
c1ccc(CN2CCO[C@H]3[C@H](Oc4ccccn4)CC[C@@H]32)nc1

$$$$
SWF000325
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  1  0  0  0
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 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000325

>  <SMILES>
O=C(c1ccnnc1)N1CCO[C@H]2[C@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF000326
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 11 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000326

>  <SMILES>
Cn1cccc1C(=O)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF000327
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  6  0  0  0
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 13 15  1  0  0  0  0
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 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000327

>  <SMILES>
O=C(c1ccco1)N1CCCC2(CN(Cc3cccs3)CCO2)C1

$$$$
SWF000328
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 18 20  2  0  0  0  0
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  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000328

>  <SMILES>
Fc1ccc(CN2CC3(CCN(Cc4ccsc4)C3)C2)cc1

$$$$
SWF000329
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -0.9787   -0.9276   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7708   -1.9057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5140   -2.5749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1802   -2.2147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4650   -2.2658   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3061   -3.5530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3550   -3.8620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3392   -3.5019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5471   -4.4801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0334   -3.1418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  7  2  0  0  0  0
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  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000329

>  <SMILES>
COCCC1CCOC12CCN(C(=O)c1ccc(F)c(F)c1)CC2

$$$$
SWF000330
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1224    1.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113    0.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903   -1.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2459   -0.7686   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 12 15  2  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000330

>  <SMILES>
c1cncc(N2CCOCC3(CCCN(Cc4ccoc4)C3)C2)c1

$$$$
SWF000331
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.6273    1.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3658    2.9590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2511    3.9627   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0931    6.9738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3225    8.9812   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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 10 13  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000331

>  <SMILES>
COC[C@@H]1CCC[C@@]12CN(Cc1ccc(OC)cc1)CCO2

$$$$
SWF000332
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000332

>  <SMILES>
C=CCN1CCC2(CCN(C(=O)c3cnccn3)CC2)C1=O

$$$$
SWF000333
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3291   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7190   -3.3681   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.8209   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6007   -4.5816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7026   -3.0545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0925   -4.4248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000333

>  <SMILES>
O=C(c1ccccn1)N1CCC2(CCC(C(=O)N3CCCC3)O2)CC1

$$$$
SWF000334
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000334

>  <SMILES>
CN(C)C(=O)COC1CCOC2(C1)CN(Cc1cccnc1)C2

$$$$
SWF000335
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000335

>  <SMILES>
Cc1ccc(N2CCC3(CCN(C(=O)c4cnccn4)CC3)CC2)nn1

$$$$
SWF000336
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000336

>  <SMILES>
O=C(c1ccncc1)N1C[C@@H]2CN(C(=O)c3cnccn3)C[C@@H]2C1

$$$$
SWF000337
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 11 13  1  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000337

>  <SMILES>
CS(=O)(=O)NC[C@]12COC[C@H]1CN(C(=O)c1ccco1)C2

$$$$
SWF000338
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000338

>  <SMILES>
c1ccc(CN2CCOC3CCC2C3OCc2ccncc2)cc1

$$$$
SWF000339
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000339

>  <SMILES>
Cc1ccc(CN2CC[C@H]3OCC[C@@H](C(=O)N4CCCC4)[C@@H]3C2)o1

$$$$
SWF000340
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.6032   -4.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000340

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(Cc3nccs3)CC2)CO1

$$$$
SWF000341
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9407   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000341

>  <SMILES>
O=C(c1cccnc1)N1CCC2(C1)CN(C(=O)c1ccco1)C2

$$$$
SWF000342
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000342

>  <SMILES>
c1ccc(CO[C@H]2CN(Cc3ccsc3)[C@@H]3CCCO[C@H]23)nc1

$$$$
SWF000343
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000343

>  <SMILES>
Cn1cc(CN2CCC3(CC2)C(=O)NCCN3CC2CC2)cn1

$$$$
SWF000344
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000344

>  <SMILES>
O=C(c1cscn1)N1CCC2(CCN(Cc3ccoc3)CC2)C1

$$$$
SWF000345
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000345

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1ccccn1)CC2

$$$$
SWF000346
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000346

>  <SMILES>
O=C1CCC2(CCN(Cc3ccncc3)CC2)N1Cc1ccccc1

$$$$
SWF000347
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.9577    2.5112   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000347

>  <SMILES>
C=CCN1C(=O)CC[C@]12CCCN(Cc1ccco1)[C@H]2CC

$$$$
SWF000348
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000348

>  <SMILES>
Cn1cc(CN2CCN3CC(OCc4cccnc4)CC3C2)cn1

$$$$
SWF000349
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000349

>  <SMILES>
Cc1cnc(N2CCc3ccc(=O)n(Cc4cccnc4)c3CC2)nc1

$$$$
SWF000350
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000350

>  <SMILES>
Cn1cnc2c(-c3ccccc3)nc(C3CCN(Cc4ccsc4)CC3)cc21

$$$$
SWF000351
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000351

>  <SMILES>
COCC1CC2(CCN(Cc3ccoc3)CC2)CN1c1ncccn1

$$$$
SWF000352
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000352

>  <SMILES>
O=C(c1cocn1)N1CC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF000353
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000353

>  <SMILES>
CCN1CC2(CCN(Cc3ccc(F)cc3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF000354
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000354

>  <SMILES>
CN1C[C@H]2C3(CCN(C(=O)c4cccs4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF000355
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000355

>  <SMILES>
Cn1cnc2c(-c3ccccc3)nc(C3CCN(C(=O)c4cccnc4)CC3)cc21

$$$$
SWF000356
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000356

>  <SMILES>
O=S1(=O)NCC2(CCN(Cc3ccccn3)CC2)COc2ccccc21

$$$$
SWF000357
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000357

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2C[C@@H](CC(=O)NCc3cccnc3)O[C@@H]2C1

$$$$
SWF000358
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000358

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(C(=O)NC(C)C)C[C@@H]32)C(=O)N1CC1CC1

$$$$
SWF000359
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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   10.3622    3.0147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 26  2  0  0  0  0
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 25 28  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 23 26  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000359

>  <SMILES>
O=C1NCCC12CN(Cc1cccnc1)CC21CCN(Cc2ccoc2)CC1

$$$$
SWF000360
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.9361   -8.8220   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000360

>  <SMILES>
O=C1CCC2(CCN(Cc3ccoc3)CC2)N1Cc1ccccc1

$$$$
SWF000361
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2811   -7.8348   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000361

>  <SMILES>
Cc1cccc(CN2C(=O)CCC23CCN(Cc2ccco2)CC3)c1

$$$$
SWF000362
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3846   -3.1317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3563   -4.4015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  7  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000362

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(Cc3cnn(C)c3)CC2)O1

$$$$
SWF000363
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2836    1.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000363

>  <SMILES>
C=CCN1CC2(CCN(Cc3cnn(C)c3)CC2)OCC1=O

$$$$
SWF000364
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000364

>  <SMILES>
c1csc(CN2CCC3(CCN(Cc4nccs4)CC3)C2)c1

$$$$
SWF000365
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000365

>  <SMILES>
C=CCN1CCN(C)C(=O)C12CCN(C(=O)c1ccncc1)C2

$$$$
SWF000366
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000366

>  <SMILES>
c1cnc(N2CCO[C@H]3[C@H](OCc4cccnc4)CC[C@@H]32)nc1

$$$$
SWF000367
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000367

>  <SMILES>
O=C(NC1CCC1)[C@@H]1C[C@@H]2CCN(Cc3ccoc3)C[C@@H]2O1

$$$$
SWF000368
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000368

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1ccc(C)o1)CC2

$$$$
SWF000369
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000369

>  <SMILES>
O=C1CC2(CCN(Cc3cccs3)C2)CN1c1cccc(F)c1

$$$$
SWF000370
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10 16  1  0  0  0  0
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 15 18  1  1  0  0  0
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 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000370

>  <SMILES>
O=C(c1ccncc1)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF000371
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3280    0.6672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000371

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF000372
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.7636    2.3310   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783    1.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4196    0.7872   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8462    1.2507   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1078   -0.6801   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2225   -1.6838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.3875    0.7105   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2760   -4.7954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  7 12  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 13 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  2  0  0  0  0
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 16 22  1  0  0  0  0
 17 23  1  0  0  0  0
 20 24  1  0  0  0  0
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 22 26  1  0  0  0  0
 24 27  2  0  0  0  0
 10 12  2  0  0  0  0
 14 18  1  0  0  0  0
 17 20  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000372

>  <SMILES>
COCCn1c(C(=O)Nc2cccc(C)c2)cc2c1c1ccccc1n2C

$$$$
SWF000373
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1147   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.4034   -8.7470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6003   -9.8617   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000373

>  <SMILES>
c1cncc(O[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2cccs2)c1

$$$$
SWF000374
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 11  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 14 10  1  1  0  0  0
 11 12  2  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000374

>  <SMILES>
O=C(c1ccco1)N1CC[C@H]2C[C@H](c3nnc(C4CC4)o3)O[C@@H]2C1

$$$$
SWF000375
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6647    1.8841   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
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 20 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000375

>  <SMILES>
O=C(C1CCOC1)N1CC[C@@H](OCC2CC2)[C@@H]1Cc1ccccc1

$$$$
SWF000376
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 12  9  1  6  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000376

>  <SMILES>
Cc1nnc(C[C@@H]2OC[C@H]3CN(C(=O)Cc4ccccn4)CC[C@H]32)o1

$$$$
SWF000377
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.6227   -0.2865   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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  3  7  1  0  0  0  0
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  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  7  1  0  0  0  0
  9 12  1  0  0  0  0
 14 15  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000377

>  <SMILES>
Cc1nnc([C@H]2C[C@@H]3CCN(Cc4cnn(C)c4)C[C@H]3O2)[nH]1

$$$$
SWF000378
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 17 22  1  0  0  0  0
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 21 25  1  0  0  0  0
 21 26  1  0  0  0  0
 23 27  1  0  0  0  0
 24 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000378

>  <SMILES>
CC(C)n1cnc2c1C(C(=O)Nc1cccc(Cl)c1)N(Cc1ccccc1)CC2

$$$$
SWF000379
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.6993    1.3065   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7064    1.1871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000379

>  <SMILES>
Cc1ccc(CN2CCOCC3(CC(CN(C)C)CO3)C2)o1

$$$$
SWF000380
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000380

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccoc3)CC2)CN1c1ncccn1

$$$$
SWF000381
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000381

>  <SMILES>
CN(C)C(=O)N1CCC2(CCN(C(=O)c3cnccn3)CC2)CC1

$$$$
SWF000382
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000382

>  <SMILES>
CS(=O)(=O)NC[C@H]1OC[C@@H]2CN(Cc3cccnc3)CC[C@@H]21

$$$$
SWF000383
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    1.9969   -4.1844   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7222   -3.4961   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000383

>  <SMILES>
O=C(NCc1ccco1)C12CC(CN1Cc1nccs1)C2

$$$$
SWF000384
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 18  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000384

>  <SMILES>
O=C(c1ccncc1)N1CCOC2CCC1C2OCc1ccncc1

$$$$
SWF000385
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  1  0  0  0
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 21 23  1  0  0  0  0
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 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000385

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CN(Cc3ccc(C)o3)C[C@@H]2N1S(C)(=O)=O

$$$$
SWF000386
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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  5  7  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000386

>  <SMILES>
COCCN1C(=O)CCC12CCCN(Cc1ccc(C)o1)CC2

$$$$
SWF000387
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.2613    2.4803   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  2  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000387

>  <SMILES>
O=C(Cc1ccsc1)N1Cc2cncn2CC(COCC2CC2)C1

$$$$
SWF000388
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    4.5996   -4.0281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0983   -3.8706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000388

>  <SMILES>
CCN1CCC2(CN(CCOC)CC23CCN(C(=O)c2cccc(C)c2)CC3)C1=O

$$$$
SWF000389
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 29 30  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000389

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(C(=O)c4cc(C)oc4C)C3)C2)cc1

$$$$
SWF000390
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 15  2  0  0  0  0
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 22 25  1  0  0  0  0
 10 13  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000390

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cncc(C)c2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000391
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000391

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ncccn2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000392
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   12.0455   -0.7842   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.2023   -2.2760   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4158   -1.3943   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6556    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.8692    1.4678   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4988    2.0779   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000392

>  <SMILES>
CN1C(COCC2CC2)CCC12CCN(S(=O)(=O)C1CC1)CC2

$$$$
SWF000393
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000393

>  <SMILES>
O=C(c1ccccn1)N1CCCC2(CC(n3ccnc3)CO2)C1

$$$$
SWF000394
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.5793   -2.0773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000394

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1cc(C)oc1C)CC2

$$$$
SWF000395
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.6537   -2.0932   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000395

>  <SMILES>
c1cc(CN2CCC3(CC2)CC(OCC2CCC2)CO3)cs1

$$$$
SWF000396
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000396

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccncc2)C[C@@H]1Cc1ccccc1

$$$$
SWF000397
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 12 14  1  1  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000397

>  <SMILES>
O=C(c1ccncn1)N1C[C@@H]2CN(Cc3cccs3)CCO[C@@H]2C1

$$$$
SWF000398
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 11 15  2  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000398

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccc(C)nc2)C[C@@H]1Cc1ccccc1

$$$$
SWF000399
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 16 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 25 27  2  0  0  0  0
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 17 18  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000399

>  <SMILES>
O=C(c1ccoc1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)CC1

$$$$
SWF000400
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF000400

>  <SMILES>
COCCN1CCC2(COCc3c(C)nc(NCC4CC4)nc32)C1

$$$$
SWF000401
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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  9 10  1  0  0  0  0
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 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000401

>  <SMILES>
Cn1nccc1C(=O)N1C[C@H]2CCC[C@@]2(COc2ccccn2)C1

$$$$
SWF000402
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0404   -4.3385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6227   -3.6341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000402

>  <SMILES>
C1CO[C@H]2[C@@H](N3CCOCC3)CN(CC3CCOCC3)[C@H]2C1

$$$$
SWF000403
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.5489    1.9597   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0597    1.7806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6175    0.9070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4607   -0.5848   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7771   -0.9075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1966   -1.3923   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3757   -2.8816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7550   -3.4711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9552   -2.5714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3134   -5.5499   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.3345   -3.1609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5136   -4.6502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000403

>  <SMILES>
CN(C)CC1COC2(COCCN(Cc3cccnc3)C2)C1

$$$$
SWF000404
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7195   -1.3849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5724    1.0036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7416    2.6128   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2361    1.6422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8239    2.4512   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6374    0.6242   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0441   -0.2894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0386   -0.3939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2197    1.3286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6264    0.4151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000404

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(C(=O)Nc4ccccc4)C[C@@H]32)C(=O)N1CC(C)C

$$$$
SWF000405
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9282   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2532   -5.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8712   -5.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622   -6.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 15  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000405

>  <SMILES>
O=C(CCO)N1CCOC2(CCCN(C(=O)c3ccco3)C2)C1

$$$$
SWF000406
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.2275   -2.6728   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -3.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -3.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -1.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -4.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5468    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000406

>  <SMILES>
O=C(CCO)N1CCC2(CC(Nc3ncccc3F)CO2)C1

$$$$
SWF000407
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    1.7321    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1120    1.6235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000407

>  <SMILES>
CC(C)Nc1nc2c(cc1C(=O)N(C)C)CCN(c1ncccn1)CC2

$$$$
SWF000408
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.0488   -5.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2988   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9089   -3.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF000408

>  <SMILES>
CC(C)NC(=O)c1ccc2c(c1)C1(CCN(C)CC1)C(=O)N2

$$$$
SWF000409
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.5793   -2.0773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 18 21  2  0  0  0  0
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 21 23  1  0  0  0  0
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 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000409

>  <SMILES>
COCC1C(=O)NCC12CCN(Cc1cc(C)ccc1C)CC2

$$$$
SWF000410
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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 10 13  1  0  0  0  0
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 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000410

>  <SMILES>
Cc1cccc(CN2CCC[C@]3(C[C@H](Oc4ccccn4)CO3)C2)n1

$$$$
SWF000411
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000411

>  <SMILES>
c1ccc(O[C@@H]2CO[C@@]3(CCCN(Cc4ccoc4)C3)C2)nc1

$$$$
SWF000412
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
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 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000412

>  <SMILES>
CNC(=O)CC1CC2(CCN(Cc3cccnc3)CC2)Oc2ccccc21

$$$$
SWF000413
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000413

>  <SMILES>
O=C1CCC2(CCCN(CC3CC3)CC2)N1Cc1cccc(F)c1

$$$$
SWF000414
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0456   -4.4836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000414

>  <SMILES>
CC(=O)N1CCC2(c3ccccc3)CCN(CC(=O)O)CC12

$$$$
SWF000415
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.9033    0.1754   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2171    1.0050   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2779   -0.8324   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7021    0.6374   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9958   -0.2515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6156    0.2307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8066    1.6319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5518   -0.4600   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2848    0.9738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6765    1.0560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7848    1.8398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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  7 10  1  0  0  0  0
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 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000415

>  <SMILES>
CS(=O)(=O)N1C2CCC1CN(C(=O)Cc1cccc(F)c1)C2

$$$$
SWF000416
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4533   -2.1790   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0674   -0.7997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5443   -0.4857   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3125    0.5079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7022    1.0159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0101    2.0372   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5124    7.1751   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000416

>  <SMILES>
CC(=O)N1CCC2(CC1)CN(CC(C)C)CC21CCNC1=O

$$$$
SWF000417
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    9.5979    6.4721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3479    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8479    5.1731   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5979    3.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5979    3.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1061    3.7172   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2080    2.5037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0979    3.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3969    3.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000417

>  <SMILES>
O=C(NCC1CC1)[C@@H]1C[C@@H]2CCN(CCOCc3ccccc3)C[C@@H]2O1

$$$$
SWF000418
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000418

>  <SMILES>
O=C(c1cccnc1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF000419
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952    4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9952    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000419

>  <SMILES>
CN(C)S(=O)(=O)N1CCC2(CCOCC2COCC2CC2)CC1

$$$$
SWF000420
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000420

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@H](C(=O)Nc4cccnc4C)O[C@@H]3C2)cc1

$$$$
SWF000421
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6 10  1  0  0  0  0
  9 13  1  0  0  0  0
 19 20  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000421

>  <SMILES>
CN(Cc1ccco1)[C@@H]1CN(Cc2cccnc2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF000422
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8974   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8974   -4.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  1  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000422

>  <SMILES>
O=C(c1ccnnc1)N1CC[C@]2(C[C@H](Oc3ncccc3F)CO2)C1

$$$$
SWF000423
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.9641   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1867   -0.6810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4822    0.9013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
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 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000423

>  <SMILES>
c1ccc(NCC[C@@]23CCO[C@@H]2CCN(Cc2ccncc2)C3)nc1

$$$$
SWF000424
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0190   -4.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000424

>  <SMILES>
CN(C)[C@@H]1CCO[C@]2(CCN(C(=O)/C=C/c3cccs3)C2)C1

$$$$
SWF000425
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8660    3.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    3.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1340    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6340    4.2709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6340    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6340    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6340    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1340    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000425

>  <SMILES>
O=C(c1cnccn1)N1C[C@@H]2OCCN(c3ncccn3)[C@@H]2C1

$$$$
SWF000426
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.3925    7.5702   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.1425    6.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3925    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    6.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1425    3.6731   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    4.9721   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    2.2172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090   -1.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3109   -0.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7008   -1.6240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3371   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5871   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000426

>  <SMILES>
O=C(C[C@]12COC[C@H]1CN(c1ncc(F)cn1)C2)N1CC(F)(F)C1

$$$$
SWF000427
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7466    0.7273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9277    2.4499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3344    1.5363   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000427

>  <SMILES>
O=C(c1ccncc1)N1CCC[C@]2(C[C@@H](OCc3ccccn3)CO2)C1

$$$$
SWF000428
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8971    7.3461   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    6.3424   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.5961   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    5.1289   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665    7.2062   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    2.2172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  2  0  0  0  0
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  4  7  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000428

>  <SMILES>
Cc1cc(CN2C[C@@H]3COC[C@]3(CNc3ccccn3)C2)no1

$$$$
SWF000429
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  1  0  0  0
 13 15  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000429

>  <SMILES>
Cc1noc(C)c1CN1CCO[C@H]2CN(C(=O)c3ccoc3)C[C@H]21

$$$$
SWF000430
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000430

>  <SMILES>
COc1cc(NCc2cnc3n2CCN(CC2CC2)CC3)ncn1

$$$$
SWF000431
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8053   -5.6119   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000431

>  <SMILES>
O=C(c1ncn2c1CNS(=O)(=O)c1ccccc1-2)N1CCOCC1

$$$$
SWF000432
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000432

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(Cc3cccs3)CC2)O1

$$$$
SWF000433
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000433

>  <SMILES>
O=C(c1ccsc1)N1CCC2(CC(=O)N(c3ccccc3)C2)C1

$$$$
SWF000434
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8712    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 18 21  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF000434

>  <SMILES>
O=C(C1Cn2ccnc2C2(CCN(Cc3ccco3)CC2)O1)N1CCCC1

$$$$
SWF000435
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000435

>  <SMILES>
CC(=O)N1CCOCC2(C1)CN(C(=O)c1ccsc1)CCO2

$$$$
SWF000436
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.0863    1.1401   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5128    0.6766   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6597    1.6036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6227   -0.2865   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5498    2.5667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8 10  1  0  0  0  0
 13 16  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000436

>  <SMILES>
CS(=O)(=O)N1CCC2(c3ccccc3)CCN(Cc3cccs3)CC12

$$$$
SWF000437
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.5109   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8417   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0109   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0327   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000437

>  <SMILES>
Cn1cc2c(n1)C(COCC1CC1)CN(Cc1ccsc1)C2

$$$$
SWF000438
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1391   -4.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8301   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000438

>  <SMILES>
c1coc(CN2CCC3(CC2)CCN(Cc2nccs2)CC3)c1

$$$$
SWF000439
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3180   -0.0889   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5397   -2.1986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4837   -1.0329   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.8572   -2.0896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.6072   -4.3979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000439

>  <SMILES>
O=C(c1ccco1)N1CC2(CCN(Cc3ccsc3)C2)C1

$$$$
SWF000440
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    8.8531   -0.1872   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7383    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1626    7.7836   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5068   10.7946   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6536   11.7217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  1  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000440

>  <SMILES>
CC(C)CN1C[C@@H]2C(=O)N(C)C3(CCN(C(=O)Cc4ccccc4)CC3)[C@@H]2C1

$$$$
SWF000441
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    5.9020   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0930    2.6147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988    2.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7751    5.1890   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4693    5.5492   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2614    6.5273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8456    8.4836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000441

>  <SMILES>
CN(C)C(=O)N1C[C@@H]2C(=O)N(C)C3(CCN(C(=O)Cc4ccccc4)CC3)[C@@H]2C1

$$$$
SWF000442
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   11.3846   -2.7227   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.8334   -3.1109   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4452   -1.6620   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4714   -1.5326   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.1888   -4.2099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9843   -1.3369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2214   -0.2336   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9988   -5.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5746   -4.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4714    1.0654   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5985   -3.7372   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5804   -7.1842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000442

>  <SMILES>
CCN1CC2(CCN(C(=O)NC(C)C)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF000443
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    8.2112   -2.2515   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6747   -3.6781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6784   -2.5633   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8233   -2.8203   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6319   -0.8117   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5132   -2.0898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7336   -4.3176   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7685    0.4149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1258   -0.6772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000443

>  <SMILES>
CN1Cc2c(C(=O)Nc3cccnc3)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF000444
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5885   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   15.5885   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000444

>  <SMILES>
CC(C)N(C)CC1CCC2(CCN(Cc3cccnc3)CC2)CO1

$$$$
SWF000445
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.2112   -2.2515   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6747   -3.6781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7685    0.4149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1259   -0.6772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
M  END
>  <HTSID>
SWF000445

>  <SMILES>
CNC(=O)c1ncn2c1CN(C)S(=O)(=O)c1ccccc1-2

$$$$
SWF000446
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000446

>  <SMILES>
O=C1COC2(CCN(Cc3cccnc3)CC2)CN1Cc1ccccn1

$$$$
SWF000447
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    8.4016   -2.5402   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000447

>  <SMILES>
O=C(c1ccncc1)N1CC[C@@H]2NS(=O)(=O)c3ccccc3O[C@H]2CC1

$$$$
SWF000448
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.6418    3.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000448

>  <SMILES>
COCC1CN(C(=O)CC2Cc3ccccc3C2)Cc2cncn2C1

$$$$
SWF000449
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000449

>  <SMILES>
CN1CC2(CCN(C(=O)Cc3ccccn3)CC2)OCC1=O

$$$$
SWF000450
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
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 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000450

>  <SMILES>
Cc1cc(C(=O)N2CCC3(CC2)C(=O)N(C)CCN3C)[nH]n1

$$$$
SWF000451
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  2  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000451

>  <SMILES>
O=C(c1ccco1)N1CCO[C@@H]2CN(c3ccccn3)CC[C@@H]2C1

$$$$
SWF000452
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 18 21  1  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 16 19  1  0  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000452

>  <SMILES>
Cc1cccc(NC(=O)N2CCCC3(CC(C(=O)NCc4ccncc4)=NO3)C2)c1

$$$$
SWF000453
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF000453

>  <SMILES>
CCc1cnc(N2CC[C@@H]3CN(CC)S(=O)(=O)[C@@H]3CC2)nc1

$$$$
SWF000454
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF000454

>  <SMILES>
CCN1CCC2(CC1)C(=O)Nc1ccc(C(=O)N(C)C)cc12

$$$$
SWF000455
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000455

>  <SMILES>
CN1C(=O)C2(CCN(Cc3cnn(C)c3)CC2)C1c1ccccc1

$$$$
SWF000456
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000456

>  <SMILES>
Cc1cnc(N2CCC3(CC2)CC(=O)N(C)c2ccccc23)nc1

$$$$
SWF000457
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000457

>  <SMILES>
CS(=O)(=O)NCC1CC12CCN(Cc1nccs1)CC2

$$$$
SWF000458
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF000458

>  <SMILES>
Cc1cc(CN2CC[C@H]3C[C@H](C(=O)Nc4cccnc4)O[C@H]3C2)no1

$$$$
SWF000459
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
 11  9  1  6  0  0  0
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M  END
>  <HTSID>
SWF000459

>  <SMILES>
Cc1noc(C)c1CN1CC[C@@H]2OC[C@H](C(=O)N(C)C)C[C@@H]2C1

$$$$
SWF000460
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 11 18  1  0  0  0  0
 13 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 12 15  1  0  0  0  0
 14 19  1  0  0  0  0
 21 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000460

>  <SMILES>
COCCN1CC2(CCN(Cc3ccccc3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF000461
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.1016    4.3730   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1623    5.4336   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7134    5.8218   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6145    4.1772   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2917    3.4599   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7013    2.9872   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8645    5.4762   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4875    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4817    4.3730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5743    0.7826   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8733    1.3987   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8675    3.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0872    0.5869   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0633    2.3118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000461

>  <SMILES>
CN1CCC2(CC1)COc1ccccc1S(=O)(=O)N(C)C2

$$$$
SWF000462
Actelion Java MolfileCreator 1.0

 28 30  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9835    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5003    1.2677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8689   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0841   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4169   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8041    0.8256   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6008   -2.4694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6669   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9001   -1.9670   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2874    0.6020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8354   -0.7943   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322   -5.6069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988   -5.1647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3786   -6.2643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.4740   -4.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1041   -7.0301   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  1  0  0  0
 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000462

>  <SMILES>
CC(C)C(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(CCN(C)C)[C@H]2CC1

$$$$
SWF000463
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1029    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0534   -1.0311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3682   -3.9500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1530   -2.0513   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8016   -4.3921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3400   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9380   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -2.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2371   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9380   -1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2371   -2.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000463

>  <SMILES>
CN(C)C(=O)CN1C[C@H]2CCN(Cc3ccccc3)CC[C@H]2S1(=O)=O

$$$$
SWF000464
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.5823   -5.1132   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2486   -3.6508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471   -6.2860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471   -6.2860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5457   -3.6508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2119   -5.1132   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7495   -5.4470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3074   -6.8804   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1121   -7.3652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2071   -8.0806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0897   -8.8650   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3437   -9.3071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8285  -10.7266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  6  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000464

>  <SMILES>
CC(C)N1CCOC2(COCCN(Cc3cnn(C)c3)C2)C1

$$$$
SWF000465
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1794   -2.7295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0600   -1.7367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7931   -1.0565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1866   -1.2497   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3727   -0.1492   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3799   -0.2686   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4243   -0.5633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8085    2.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233    0.9972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3747    3.2555   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8058    2.2798   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2396    1.3789   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3691    3.1061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000465

>  <SMILES>
CC(C)C(=O)N1CCN(C(=O)Cc2ccccc2)CC2(CNC(=O)C2)C1

$$$$
SWF000466
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7050    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000466

>  <SMILES>
O=C(c1ccoc1)N1CCC2(CCN(Cc3cccnc3)C2)CC1

$$$$
SWF000467
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.5349    1.9042   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000467

>  <SMILES>
O=C(c1ccnnc1)N1CCC2(CCCN(C(=O)c3cnccn3)C2)C1

$$$$
SWF000468
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000468

>  <SMILES>
CCO[C@@H]1CO[C@@]2(CCN(Cc3cc(OC)cc(OC)c3)C2)C1

$$$$
SWF000469
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000469

>  <SMILES>
O=C(c1cnccn1)N1CCOC2(CCCN(c3cnccn3)C2)C1

$$$$
SWF000470
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000470

>  <SMILES>
CC(C)C(=O)N1CCC2(COCc3cnc(N(C)C)nc32)C1

$$$$
SWF000471
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9407   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000471

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CN(CC3CCOCC3)C2)C1

$$$$
SWF000472
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7419   -1.5792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000472

>  <SMILES>
COc1ccccc1CN1CCOC2CCC1C2OCC1CC1

$$$$
SWF000473
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000473

>  <SMILES>
O=C(N1CCCC1)N1CCO[C@@H]2[C@@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF000474
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    7.0542   -3.0658   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.3110   -3.7350   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7973   -2.3967   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3850   -2.3227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000474

>  <SMILES>
C=CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)CS(C)(=O)=O

$$$$
SWF000475
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.6425    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    4.4230   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    5.1730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1425    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
  8 12  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  1  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000475

>  <SMILES>
Cc1ccccc1S(=O)(=O)N1C[C@@H]2COC[C@]2(CN(C)C)C1

$$$$
SWF000476
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.9510    6.7418   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4182    7.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1645    4.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1682    5.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0283    8.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000476

>  <SMILES>
Cc1ccc(CN2CCC3(CCOCC3NC(=O)C(C)C)CC2)s1

$$$$
SWF000477
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 14  1  6  0  0  0
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 20 24  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000477

>  <SMILES>
Cc1noc(C)c1CN1CC[C@H]2C[C@H](C(=O)NC3CCC3)O[C@H]2C1

$$$$
SWF000478
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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 10  8  1  6  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 11  1  6  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000478

>  <SMILES>
c1csc(CN2CC[C@H]3CO[C@H](CN4CCOCC4)[C@H]3C2)n1

$$$$
SWF000479
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4480   -1.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291    0.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  2  0  0  0  0
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 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000479

>  <SMILES>
O=C1N(c2cncnc2)CCC12CCCN(Cc1ccco1)C2

$$$$
SWF000480
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.5077    3.1532   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4273    3.5462   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2274    2.9464   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0342    1.9653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0285    3.0003   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856    5.9250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 14 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF000480

>  <SMILES>
CN(C)CC1CCC2(COCCN(C(=O)c3ccnnc3)C2)O1

$$$$
SWF000481
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5126    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
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 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000481

>  <SMILES>
CCc1ccc(CN2CC[C@H]3C[C@H](C(=O)N4CCCO4)O[C@@H]3C2)o1

$$$$
SWF000482
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
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  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000482

>  <SMILES>
c1cncc(CN2CCOC3(CCN(Cc4ccco4)CC3)C2)c1

$$$$
SWF000483
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000483

>  <SMILES>
O=C(NC1CC1)[C@@]12CCO[C@@H]1CCN(Cc1ccc3c(c1)OCO3)C2

$$$$
SWF000484
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.2685    3.7435   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 19 20  1  0  0  0  0
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 13 11  1  1  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000484

>  <SMILES>
O=C(NC1CCC1)[C@@H]1C[C@@H]2CCN(Cc3cccs3)C[C@@H]2O1

$$$$
SWF000485
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF000485

>  <SMILES>
O=C1N(Cc2ccccn2)CCC12CCN(Cc1cccnc1)CC2

$$$$
SWF000486
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.1172    1.1997   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000486

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCO[C@]2(CCN(C(=O)c3ccco3)C2)C1

$$$$
SWF000487
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000487

>  <SMILES>
Cc1noc(C[C@]23COC[C@H]2CN(S(=O)(=O)c2ccccc2)C3)n1

$$$$
SWF000488
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.5353    5.3460   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    5.3460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7853    4.0470   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7853    6.6450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    2.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2771    6.8018   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000488

>  <SMILES>
Cn1ccc(C(=O)NC2CCC23CCN(C(=O)c2ccco2)CC3)c1

$$$$
SWF000489
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000489

>  <SMILES>
C=CCN1CCC2(CCN(C(=O)c3ccc(C)o3)CC2)C1=O

$$$$
SWF000490
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000490

>  <SMILES>
Cc1ccc(CN2CC3(CCN(Cc4ccsc4)C3)C2)s1

$$$$
SWF000491
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.6273    1.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
  7 10  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000491

>  <SMILES>
Cc1ccc(CN2CCO[C@]3(CCC[C@H]3COc3cccnc3)C2)o1

$$$$
SWF000492
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.2831    5.6274   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7831    4.7614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9522    6.3706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7612    4.9693   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000492

>  <SMILES>
Cc1ccsc1C(=O)N1CC[C@]2(CCC[C@@H](CN(C)C)O2)C1

$$$$
SWF000493
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000493

>  <SMILES>
CN(C)C(=O)COC1COC2(CCN(Cc3ccoc3)CC2)C1

$$$$
SWF000494
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000494

>  <SMILES>
C=CCN1CCC2(CCN(C(=O)c3ccoc3C)CC2)C1=O

$$$$
SWF000495
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000495

>  <SMILES>
COCC1CCS(=O)(=O)C12CN(Cc1ccc(OC)cc1)C2

$$$$
SWF000496
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000496

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(Cc4cnn(C)c4)C3)C2=O)n1

$$$$
SWF000497
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000497

>  <SMILES>
Cn1cc(CN2C[C@@H]3[C@H](CC(=O)N4CCCCO4)CO[C@@H]3C2)cn1

$$$$
SWF000498
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000498

>  <SMILES>
O=C(C1CCC2(CCN(Cc3nccs3)CC2)O1)N1CCCO1

$$$$
SWF000499
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  6  0  0  0
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 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000499

>  <SMILES>
CN(C)C(=O)NC[C@H]1CCC[C@]2(CCN(Cc3cccnc3)C2)O1

$$$$
SWF000500
Actelion Java MolfileCreator 1.0

 31 35  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 28 31  2  0  0  0  0
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 27 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  END
>  <HTSID>
SWF000500

>  <SMILES>
O=C(c1ccco1)N1CCC[C@]2(C(=O)N3CCOCC3)CN(c3ncccn3)C[C@@H]2C1

$$$$
SWF000501
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000501

>  <SMILES>
O=C(c1ccncn1)N1C[C@@H]2CN(Cc3cccnc3)CCO[C@@H]2C1

$$$$
SWF000502
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  6  0  0  0
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 12 17  1  0  0  0  0
 18 20  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000502

>  <SMILES>
COCC1CN(C(=O)c2ccc3c(c2)OCO3)Cc2c1cnn2C

$$$$
SWF000503
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000503

>  <SMILES>
CN(C)C(=O)COC[C@]12COC[C@H]1CN(Cc1ccccn1)C2

$$$$
SWF000504
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000504

>  <SMILES>
c1coc(CN2CCC3(CCN(Cc4nccs4)CC3)C2)c1

$$$$
SWF000505
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.0622    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 13  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000505

>  <SMILES>
CNC(=O)[C@H]1C[C@H]2OCC[C@H]2N(CCOCc2ccccc2)C1

$$$$
SWF000506
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  6  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000506

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cnoc2)C[C@@H]1Cc1ccccc1

$$$$
SWF000507
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.3805    6.3424   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    7.3461   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2406    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
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 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000507

>  <SMILES>
Cc1ccc(CN2C[C@@H]3COC[C@]3(CNC(=O)C(C)C)C2)s1

$$$$
SWF000508
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    9.1018   -0.7783   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1236   -0.5703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6236   -1.4364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2927   -2.1795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  6  0  0  0
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 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 21 24  2  0  0  0  0
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 12 14  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000508

>  <SMILES>
C=CCO[C@H]1CCN(C(=O)Cc2ccsc2)[C@H]1Cc1cccnc1

$$$$
SWF000509
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3776   -1.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  7 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000509

>  <SMILES>
Cn1cc(C2COC3(CCN(Cc4cccnc4)CC3)C2)cn1

$$$$
SWF000510
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.6747   -4.3761   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000510

>  <SMILES>
O=C(NCC1CC1)C1CN(Cc2cccs2)CC12CCOCC2

$$$$
SWF000511
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.6458   -1.5873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000511

>  <SMILES>
CN(C)C(=O)CN1C[C@H]2CCCN(Cc3cnn(C)c3)[C@H]2C1

$$$$
SWF000512
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6603    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000512

>  <SMILES>
C=CCN1CC2(CCN(Cc3cccnc3)CC2)OCC1=O

$$$$
SWF000513
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9242    2.7772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000513

>  <SMILES>
c1ccc(CO[C@H]2CC[C@H]3[C@H]2OCCN3C2CCOCC2)nc1

$$$$
SWF000514
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0772   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4949   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9016   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8961   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1164   -6.2702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5231   -7.1837   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000514

>  <SMILES>
CNC(=O)CC1COC2(CCN(c3ncc(C)cn3)CC2)C1

$$$$
SWF000515
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000515

>  <SMILES>
Cc1cc(C(=O)N2CC[C@H]3OCC[C@@]3(c3nnc(C)o3)C2)no1

$$$$
SWF000516
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.9955   -4.2117   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.9955   -4.2117   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  2  0  0  0  0
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 13 10  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000516

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)CCO)C3)CC2=O)cs1

$$$$
SWF000517
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000517

>  <SMILES>
O=C(c1ccccn1)N1CC2CN(C(=O)c3cscn3)CC2C1

$$$$
SWF000518
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.5907   -0.1910   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  8  1  1  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000518

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(Cc4ccoc4)C[C@H]3O2)sc1C

$$$$
SWF000519
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000519

>  <SMILES>
Cc1noc(C)c1CN1CC[C@H]2C[C@@H](C(=O)NC3CCC3)O[C@H]2C1

$$$$
SWF000520
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000520

>  <SMILES>
CCN1CCC2(CCN(C(=O)c3cccc(C)n3)CC2)C1=O

$$$$
SWF000521
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3147   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147    0.8956   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7215    1.8092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3202    1.0002   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9783    2.4783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1123    1.9783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0828    3.4728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  6  9  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
  9 11  1  0  0  0  0
 15 16  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000521

>  <SMILES>
Cc1nnc(C[C@@H]2COC[C@H]3CN(Cc4cnn(C)c4)C[C@@H]23)o1

$$$$
SWF000522
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4945   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3821   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5311   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4620   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7493   -5.2368   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8983   -6.2257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1816   -4.8715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1165   -6.8492   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9634   -5.4950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8144   -6.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5962   -7.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  1  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000522

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3CN(Cc4ccsc4)CCO[C@@H]3C2)cn1

$$$$
SWF000523
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    3.4899   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8380    3.7989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0949    3.1298   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8833    3.3377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1994    2.1353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3833    2.4717   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7142    1.7285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 14 17  1  0  0  0  0
 16 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000523

>  <SMILES>
O=C(NCc1cccnc1)[C@@H]1C[C@@H]2[C@@H](CCN2Cc2ccoc2)O1

$$$$
SWF000524
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.2617    1.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005   -1.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3005   -1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3005   -1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8005   -2.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8005   -1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8005   -2.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8005   -1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3005   -1.9487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000524

>  <SMILES>
c1cncc(OC[C@]23COC[C@H]2CN(Cc2ccncc2)C3)c1

$$$$
SWF000525
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3917    0.5649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.6211    2.5722   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000525

>  <SMILES>
O=C(C[C@@H]1CO[C@@H]2CN(c3ncccn3)C[C@H]12)Nc1cnccn1

$$$$
SWF000526
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207   -2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162   -1.4013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4071    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6516   -5.2436   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    1.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  6  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000526

>  <SMILES>
CCn1nc(C)cc1C(=O)N1CC[C@H]2OCC[C@@]2(COC)C1

$$$$
SWF000527
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.5397   -2.1986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4837   -1.0329   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9755   -0.8761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8572   -2.0896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3936   -3.5162   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.6072   -4.3979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000527

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(Cc2ccco2)C3)cs1

$$$$
SWF000528
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -4.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  9  5  1  1  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000528

>  <SMILES>
CC(C)NC(=O)[C@@H]1C[C@@H]2CN(C(=O)c3ccccn3)C[C@@H]2C1

$$$$
SWF000529
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 23 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000529

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccncc3)CC2)Oc2ccccc21)NC1CC1

$$$$
SWF000530
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000530

>  <SMILES>
Cc1ncsc1CN1C[C@@H]2COC[C@]2(CN2CCOCC2)C1

$$$$
SWF000531
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.8100    0.0782   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4669   -1.8472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0150   -3.2435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6821   -3.7458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2650   -4.5425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2002   -5.7152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
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  9 10  2  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000531

>  <SMILES>
CN(C)CC(=O)N1CCC2(CC1)Cc1ccccc1CNC2=O

$$$$
SWF000532
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.7203    2.7275   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3304    4.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8221    4.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8258    3.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5721    5.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  8  1  0  0  0  0
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  7 10  1  1  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
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 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000532

>  <SMILES>
CC(=O)N1CCC2(COCc3cnc(NCc4ccco4)nc32)C1

$$$$
SWF000533
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 21 24  1  0  0  0  0
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 11 13  2  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000533

>  <SMILES>
Cc1cccc(CN2CCn3c(C(=O)N4CCCC4)cnc3C2)n1

$$$$
SWF000534
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  2  0  0  0  0
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 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
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 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000534

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@@H](Oc4cccnc4)CC[C@@H]32)no1

$$$$
SWF000535
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.5815    0.0675   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  6  0  0  0
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 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000535

>  <SMILES>
C=CCOC[C@H]1CCC[C@@]12CN(C(=O)c1ccoc1C)CCO2

$$$$
SWF000536
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.5349    1.9042   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000536

>  <SMILES>
Cn1cc(CN2CCC3(CCCN(C(=O)c4cccnc4)C3)C2)cn1

$$$$
SWF000537
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   12.0455   -0.7842   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.2023   -2.2760   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4158   -1.3943   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5538   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6556    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.8692    1.4678   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4988    2.0779   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000537

>  <SMILES>
CN(C)C(=O)CN1CCC2(CCN(S(=O)(=O)C3CC3)CC2)C1=O

$$$$
SWF000538
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.4090    1.0796   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000538

>  <SMILES>
O=C(c1cccs1)N1CC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF000539
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.4951    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9073    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 21 23  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000539

>  <SMILES>
CN(C)CCO[C@H]1CN(C(=O)c2ccccc2)[C@@H]2CCCO[C@H]12

$$$$
SWF000540
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0859    9.3377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 13 17  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000540

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CC(n4ccnc4)CO3)C2)o1

$$$$
SWF000541
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000541

>  <SMILES>
CC(=O)N1CC[C@]2(CCC[C@@H](CNC(=O)c3cccn3C)O2)C1

$$$$
SWF000542
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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   13.2591    0.0974   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   14.4190   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000542

>  <SMILES>
CCS(=O)(=O)N1CCC2(CCN(CCOC)C2=O)CC1

$$$$
SWF000543
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.2684    0.9463   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.9594   -0.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3339    0.3226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  6  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 13  1  6  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000543

>  <SMILES>
CN(C)C(=O)C[C@H]1OC[C@H]2CN(Cc3ccccc3F)CC[C@H]21

$$$$
SWF000544
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000544

>  <SMILES>
Cc1nc([C@@H]2C[C@H]3CN(S(=O)(=O)c4ccccc4C)C[C@H]3O2)no1

$$$$
SWF000545
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.2929   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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 11 14  1  0  0  0  0
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 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
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 16 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000545

>  <SMILES>
Cn1cc(CN2C[C@H](N3CCOCC3)[C@@H]3OCCC[C@@H]32)cn1

$$$$
SWF000546
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
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 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000546

>  <SMILES>
c1cnc(N2CCO[C@@H]3[C@@H](OCc4cccnc4)CC[C@@H]32)nc1

$$$$
SWF000547
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.2492   -0.2127   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5800    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8891    1.4815   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8401    1.7905   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3013    2.2905   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  7  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  6  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000547

>  <SMILES>
O=C([C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccoc2)O1)N1CCCO1

$$$$
SWF000548
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.9736   -6.1321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000548

>  <SMILES>
O=C(c1cccnc1)N1CC2(C1)OCCC2COCc1ccncc1

$$$$
SWF000549
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.5135    4.9687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0500    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    3.2302   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0536    2.4274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5790    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7418    0.9602   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5454    2.5842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1118    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0408    0.2102   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.1555    1.2139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000549

>  <SMILES>
CN(C)CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1ccoc1

$$$$
SWF000550
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000550

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3CN(c4ncccn4)C[C@@H]3C2)cn1

$$$$
SWF000551
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.3923   -5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  2  0  0  0  0
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 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF000551

>  <SMILES>
CN(C)CCOCC1CN(C(=O)c2cccnc2)Cc2nnn(C)c21

$$$$
SWF000552
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000552

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)c3cnoc3)CC[C@@H]2OC)cc1

$$$$
SWF000553
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
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 22 24  2  0  0  0  0
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 25 26  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000553

>  <SMILES>
Cc1ccc(N2CC[C@H]3O[C@H](C(=O)NCCN4CCCC4)CC[C@H]32)nn1

$$$$
SWF000554
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000554

>  <SMILES>
O=C(c1ccoc1)N1C[C@H](OCc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF000555
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.5135    4.9687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0500    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    3.2302   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0536    2.4274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 10 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  2  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000555

>  <SMILES>
CN(C)CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)C1CC=CC1

$$$$
SWF000556
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000556

>  <SMILES>
COc1ccccc1OCC(=O)N1C[C@@H]2[C@@H](CN3CCCC3)CO[C@@H]2C1

$$$$
SWF000557
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 15 16  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000557

>  <SMILES>
Cc1nnc([C@@H]2CCO[C@@H]3CCN(Cc4ccccc4)C[C@@H]32)o1

$$$$
SWF000558
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000558

>  <SMILES>
CCOCC1CN(C(=O)c2cc(C3CC3)on2)Cc2cncn2C1

$$$$
SWF000559
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 13  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000559

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF000560
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000560

>  <SMILES>
c1ccc(C[C@H]2CN(c3ncccn3)CC[C@@H]2OCC2CC2)cc1

$$$$
SWF000561
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.2497   -4.3738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2608   -4.5229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0250   -3.1083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000561

>  <SMILES>
Cc1cc(C(=O)N2CC[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)no1

$$$$
SWF000562
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.0524   -6.6646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6821   -7.2747   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5442   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000562

>  <SMILES>
COC1COC2(CCN(S(=O)(=O)c3ccccc3F)CC2)C1

$$$$
SWF000563
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5174   -4.9708   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5262   -6.2358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000563

>  <SMILES>
Cc1cc(C(=O)N2C[C@@H]3CN(Cc4cnn(C)c4)CCO[C@@H]3C2)on1

$$$$
SWF000564
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
 15 16  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000564

>  <SMILES>
O=S(=O)(C1CC1)N1CCCn2nnc(Cn3ccnc3)c2C1

$$$$
SWF000565
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000565

>  <SMILES>
CN1CCc2cc(C(=O)N3CCCC3)c(N(C)C)nc2CC1

$$$$
SWF000566
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.3776   -1.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000566

>  <SMILES>
c1ccc(CN2CCC3(CC2)CC(N2CCCC2)CO3)nc1

$$$$
SWF000567
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000567

>  <SMILES>
Cc1ncsc1CN1C[C@@H]2CN(Cc3cccs3)CCO[C@@H]2C1

$$$$
SWF000568
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000568

>  <SMILES>
CCOc1ccsc1C(=O)N1C[C@@H]2COC[C@]2(CN(C)C)C1

$$$$
SWF000569
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 12  1  6  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000569

>  <SMILES>
Fc1cccnc1O[C@H]1CO[C@@]2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF000570
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000570

>  <SMILES>
CO[C@H]1CCN(Cc2ccccn2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF000571
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 13  9  1  1  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000571

>  <SMILES>
CN(C)CC(=O)N1CC[C@H]2C[C@H](c3nnc(C4CC4)o3)O[C@@H]2C1

$$$$
SWF000572
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10  8  1  6  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000572

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(C(=O)c3ccco3)C2)O1

$$$$
SWF000573
Actelion Java MolfileCreator 1.0

 20 23  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000573

>  <SMILES>
c1cc(CN2CCC3(C2)CN(Cc2ccsc2)C3)cs1

$$$$
SWF000574
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11 16  2  0  0  0  0
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 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF000574

>  <SMILES>
COC[C@@H]1CCC[C@]12CN(C(=O)c1ccc3[nH]ccc3c1)CCO2

$$$$
SWF000575
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000575

>  <SMILES>
c1cncc(COC2C3CCC2N(Cc2ccco2)CCO3)c1

$$$$
SWF000576
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   11.5083   -1.7456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0411   -2.0575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000576

>  <SMILES>
O=C(c1ccccn1)N1CCO[C@H]2[C@H](OCCN3CCCC3)CC[C@@H]21

$$$$
SWF000577
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.5298   -4.0818   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5517   -3.8739   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5080   -4.2898   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000577

>  <SMILES>
CS(=O)(=O)N1C[C@H]2[C@@H](C1)OC[C@H]2C(=O)NCc1ccccn1

$$$$
SWF000578
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
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  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000578

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(C(=O)c3ccccc3)C2)O1

$$$$
SWF000579
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 11 15  2  0  0  0  0
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 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 17 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 14  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000579

>  <SMILES>
CC(C)Nc1ccnc(C2COCCN2C(=O)CCc2ccccc2)n1

$$$$
SWF000580
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
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 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000580

>  <SMILES>
CC(C)N1CC2(CCN(Cc3cccnc3)CC2)CC1COCC1CC1

$$$$
SWF000581
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 13 16  1  0  0  0  0
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 18 20  2  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000581

>  <SMILES>
O=C(c1ccco1)N1CCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF000582
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000582

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(Cc2ccco2)CC3)cc1

$$$$
SWF000583
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7372   -3.0878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000583

>  <SMILES>
C=CCN1CCN(C)C2(CCN(Cc3nccs3)CC2)C1=O

$$$$
SWF000584
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 20 23  2  0  0  0  0
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 22 25  2  0  0  0  0
 10 11  1  0  0  0  0
 12 14  1  6  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000584

>  <SMILES>
COc1ncccc1CN1C[C@@H]2[C@@H](CC(=O)NCC3CC3)CO[C@@H]2C1

$$$$
SWF000585
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000585

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccco3)CC2)CN1C(C)C

$$$$
SWF000586
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    8.8891    0.7524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2229    2.2148   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3515    0.4186   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3718    1.5182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF000586

>  <SMILES>
CCOCC1CN(S(=O)(=O)N(C)C)Cc2cncn2C1

$$$$
SWF000587
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   14.2262    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3446    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8528    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   13.6831   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  1  0  0  0  0
  9 11  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000587

>  <SMILES>
COCC(=O)N1CCC2(CC1)CC(CC(=O)NC(C)C)c1ccccc12

$$$$
SWF000588
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.7054    0.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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 15 18  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000588

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3COC[C@]3(COCC3CC3)C2)cs1

$$$$
SWF000589
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 16 18  2  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000589

>  <SMILES>
CCN1CCCn2c(nc(CNC(=O)c3cnoc3C)cc2=O)C1

$$$$
SWF000590
Actelion Java MolfileCreator 1.0

 31 34  0  0  1  0  0  0  0  0999 V2000
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 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000590

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3Oc4ccccc4S(=O)(=O)N(CCN(C)C)[C@H]3CC2)c1

$$$$
SWF000591
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   14.0695    3.9732   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   13.6060    2.5466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1387    2.2348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6096    1.4319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6752    0.8082   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1461    0.0053   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2080    0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6789   -0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5979   -0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
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 25 26  1  0  0  0  0
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 11 13  2  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000591

>  <SMILES>
CNC(=O)N1CCC2(CC1)c1ncc(-c3cccc(F)c3)n1CCN2C

$$$$
SWF000592
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5303    1.0160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000592

>  <SMILES>
Cn1cc(CN2CCCC3(CCN(C(=O)c4ccccn4)C3)C2)cn1

$$$$
SWF000593
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    7.7054    0.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000593

>  <SMILES>
O=C(c1cscn1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF000594
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 21 18  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000594

>  <SMILES>
O=C(C1CCOC1)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF000595
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    0.8660    4.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000595

>  <SMILES>
O=C(c1ccc(F)cc1)N1CCCn2nnc(CN3CCCCC3)c2C1

$$$$
SWF000596
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.0468    0.8956   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.9128    0.3956   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1808    1.3956   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
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  7  9  1  0  0  0  0
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  8 11  1  1  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000596

>  <SMILES>
CS(=O)(=O)NC[C@]12COC[C@H]1CN(C(=O)COC1CCCC1)C2

$$$$
SWF000597
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.4358    4.0132   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    4.0132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000597

>  <SMILES>
CCN(C)c1ncnc2c1CCN(C(=O)c1ccncc1)CC2

$$$$
SWF000598
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.3454    1.7454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000598

>  <SMILES>
CCC(=O)N1CCC[C@]2(C[C@@H](OCc3ccncc3)CO2)C1

$$$$
SWF000599
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
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 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
  7  8  1  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF000599

>  <SMILES>
Cc1cccc(CN2CC[C@@]3(C[C@@H](Nc4ncccn4)CCO3)C2)n1

$$$$
SWF000600
Actelion Java MolfileCreator 1.0

 27 29  0  0  1  0  0  0  0  0999 V2000
    4.8496    2.9471   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
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 26 27  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000600

>  <SMILES>
CN(C)C(=O)N1CCC[C@]2(C(=O)N(C)C)CN(Cc3cnn(C)c3)C[C@@H]2C1

$$$$
SWF000601
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000601

>  <SMILES>
CC(C)CNC(=O)CC1CC2(CCN(C(=O)c3ccco3)CC2)Oc2ccccc21

$$$$
SWF000602
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2024    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8364   -2.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.8147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8364   -2.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8364   -4.6808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3364   -3.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8364   -4.6808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8364   -2.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  2  0  0  0  0
  8 13  1  1  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 17  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000602

>  <SMILES>
COc1cc(N2C[C@H]3CCC[C@@]3(COCc3cccnc3)C2)ncn1

$$$$
SWF000603
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 11 13  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000603

>  <SMILES>
Cc1ccc(N2C[C@@H]3CCCO[C@@H]3[C@H](NS(C)(=O)=O)C2)nn1

$$$$
SWF000604
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8961   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0662   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8852   -3.7386   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8633   -3.9465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3852   -4.6046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9679   -4.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0543   -5.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  8  1  0  0  0  0
 15 14  1  1  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000604

>  <SMILES>
O=C(Nc1cccc(Cl)c1)C1=NOC2(CCCN(C(=O)N3CCCC3)C2)C1

$$$$
SWF000605
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5439   -3.4237   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2130   -4.1669   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6303   -3.8305   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1198   -5.9464   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000605

>  <SMILES>
Cc1nnc([C@H]2CO[C@@H]3CN(C(=O)/C=C/c4cccs4)C[C@H]23)o1

$$$$
SWF000606
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.6992    6.7327   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8139    5.7290   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5021    4.2618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2405    6.1925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6168    3.2581   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3552    5.1888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3049    1.7909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0434    3.7216   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783    1.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7636    2.3310   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2760   -4.7954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
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 20 24  1  0  0  0  0
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 22 26  1  0  0  0  0
 24 27  2  0  0  0  0
  6  8  1  0  0  0  0
 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000606

>  <SMILES>
COCCn1c(C(=O)Nc2cccc(Cl)c2)cc2c1c1ccccc1n2C

$$$$
SWF000607
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000607

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CC(C(=O)NCc4ccncc4)=NO3)C2)cc1

$$$$
SWF000608
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1273    5.0611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000608

>  <SMILES>
O=C(Nc1cccc(F)c1)C1CC12CCN(C(=O)Cc1ccccc1)C2

$$$$
SWF000609
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7967    2.9079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 14 11  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000609

>  <SMILES>
O=C(NC[C@H]1CCC[C@]2(CCN(C3CCC3)C2)O1)c1cccnc1

$$$$
SWF000610
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  2  0  0  0  0
 15 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000610

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cc(C)no2)[C@@H]2CN(Cc3ccco3)C[C@H]12

$$$$
SWF000611
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2221    0.0444   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000611

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccccc2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF000612
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000612

>  <SMILES>
CS(=O)(=O)NC[C@H]1CCC[C@]2(CCN(Cc3ccccc3)C2)O1

$$$$
SWF000613
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 13 16  1  0  0  0  0
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 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000613

>  <SMILES>
Cc1cccc(S(=O)(=O)N2CCc3nc(N4CCOCC4)nc(C)c3CC2)c1

$$$$
SWF000614
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 10 12  1  6  0  0  0
 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000614

>  <SMILES>
O=C1CO[C@@H]2CN(Cc3ccsc3)C[C@H]2N1Cc1ccncc1

$$$$
SWF000615
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000615

>  <SMILES>
O=C1COC2(COCCN(Cc3ccoc3)C2)CN1c1cccnc1

$$$$
SWF000616
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
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  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000616

>  <SMILES>
Cc1cccc(CN2C[C@@H]3COC[C@]3(c3nc(C)no3)C2)n1

$$$$
SWF000617
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    7.5264    3.4679   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3344    1.5363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7466    0.7273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000617

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(C(=O)c3ccccc3F)C2)C1

$$$$
SWF000618
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.2711   -0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674    0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000618

>  <SMILES>
c1cncc(CN2CC[C@H]3OCC[C@@]3(COc3cccnc3)C2)c1

$$$$
SWF000619
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  3  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000619

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(C(=O)c1ccco1)CC2

$$$$
SWF000620
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2105   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6172   -3.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6118   -3.8431   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000620

>  <SMILES>
O=C(c1ncccn1)N1CCC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF000621
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    3.3761    3.8577   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3243    2.1264   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8627    1.2837   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3752    3.7978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3230    2.0366   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2786   -2.9842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 13 17  1  6  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
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 21 23  1  0  0  0  0
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 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000621

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(C(=O)c3ccncc3)C[C@H]1CN(c1ncccn1)C2

$$$$
SWF000622
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000622

>  <SMILES>
O=C(c1ccnnc1)N1CC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF000623
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000623

>  <SMILES>
COc1cccc(CN2CCO[C@H]3[C@H](OCC4CC4)CC[C@@H]32)c1

$$$$
SWF000624
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    9.8861   -0.2865   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0044   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3127   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8861   -2.7135   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5044   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3127   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6227   -0.2865   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6227   -2.7135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5262   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  1  0  0  0
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  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 19 21  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000624

>  <SMILES>
Cc1csc([C@H]2C[C@@H]3CCN(Cc4ccoc4)C[C@H]3O2)n1

$$$$
SWF000625
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2321   -6.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000625

>  <SMILES>
O=C(NC1CCC1)[C@@H]1C[C@@H]2CCN(Cc3ccco3)C[C@@H]2O1

$$$$
SWF000626
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   10.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000626

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)C3CC3)CC[C@@H]2OC)cc1

$$$$
SWF000627
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 15  1  1  0  0  0
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 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000627

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)c3cocn3)CC[C@H]2OC)cc1

$$$$
SWF000628
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3615    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
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  7 11  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000628

>  <SMILES>
O=C(c1ccccc1)N1CC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF000629
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000629

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)c3ccoc3)CC[C@H]2OC)cc1

$$$$
SWF000630
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000630

>  <SMILES>
CCS(=O)(=O)N1CC[C@@H](OC)[C@@H](Cc2ccc(OC)cc2)C1

$$$$
SWF000631
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2321   -3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5411   -3.9899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  7 10  1  0  0  0  0
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  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000631

>  <SMILES>
O=C(Cc1ccco1)N1CC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF000632
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7026   -2.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000632

>  <SMILES>
Cn1cc(CN2CC[C@H]3OCC[C@@H](C(=O)NC4CC4)[C@H]3C2)cn1

$$$$
SWF000633
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000633

>  <SMILES>
Cc1ncoc1C(=O)N1CC[C@]2(C[C@@H](OCc3ccncc3)CO2)C1

$$$$
SWF000634
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5833    1.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000634

>  <SMILES>
O=C(NC1CC1)N1CC[C@H](OCC2CC2)[C@@H]1Cc1ccncc1

$$$$
SWF000635
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000635

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(Cc2ccoc2)CC3)cc1

$$$$
SWF000636
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000636

>  <SMILES>
O=C(C1CCCCC1)N1C[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF000637
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000637

>  <SMILES>
O=C(c1ccccn1)N1CC2CN(Cc3cccnc3)CC2C1

$$$$
SWF000638
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000638

>  <SMILES>
O=C(NCC1CC1)[C@@H]1CCO[C@@H]2CCN(CCc3ccccc3)C[C@H]21

$$$$
SWF000639
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2551    3.5204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6078    4.0556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5641    4.4714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9168    5.0067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4776    4.8782   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8950    5.2146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3731    5.8727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3950    6.0806   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000639

>  <SMILES>
CCO[C@H]1CC[C@H]2[C@@H]1OCCN2Cc1ccc2c(c1)OCO2

$$$$
SWF000640
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4834    4.7537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852    5.9672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0935    6.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   10.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13  9  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000640

>  <SMILES>
Cc1ccc(CN2C[C@@H](C(=O)NCC3CC3)C[C@H]3OCC[C@H]32)cc1

$$$$
SWF000641
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.3196    5.6150   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8278    5.7718   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2177    7.1421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462    4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7259    7.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    4.5583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097    3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1158    8.6692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8443    6.0854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826    3.1317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6241    8.8260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3525    6.2422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7424    7.6125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2506    7.7693   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6311    6.5558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000641

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(C(=O)CC4CC4)C3)C2)cc1

$$$$
SWF000642
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.8549    5.2283   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    4.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    5.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    3.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    1.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000642

>  <SMILES>
CN(Cc1ccco1)C1CCC[C@@H]2CN(C(=O)c3cccs3)C[C@H]12

$$$$
SWF000643
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.3454    1.7454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000643

>  <SMILES>
CN(C)C(=O)N1CCCC2(CC(C(=O)Nc3cccnc3)=NO2)C1

$$$$
SWF000644
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000644

>  <SMILES>
O=C(Cc1ccccn1)N1CCO[C@H]2[C@@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF000645
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000645

>  <SMILES>
Cc1nc(CN2CCC3(CC2)NC(=O)CC3c2ccncc2)cs1

$$$$
SWF000646
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000646

>  <SMILES>
C=CCN1CC[C@H]2O[C@H](C(=O)NCc3cccnc3)CC[C@H]21

$$$$
SWF000647
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 19 20  2  0  0  0  0
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M  END
>  <HTSID>
SWF000647

>  <SMILES>
c1coc(CN2C[C@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)c1

$$$$
SWF000648
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000648

>  <SMILES>
O=C(c1cnccn1)N1CC2CN(Cc3ccccn3)CC2C1

$$$$
SWF000649
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  7  9  1  6  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000649

>  <SMILES>
O=C1[C@H]2CN(Cc3ccoc3)C[C@@H]2CCN1Cc1cccnc1

$$$$
SWF000650
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  9 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000650

>  <SMILES>
COCC(=O)N1CCCC2(CC(Oc3cccnc3)CO2)C1

$$$$
SWF000651
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000651

>  <SMILES>
COCC(=O)N1CCC[C@]2(C[C@@H](Oc3cccnc3)CO2)C1

$$$$
SWF000652
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000652

>  <SMILES>
CN(C)C(=O)N1CCC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF000653
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.6770   -1.2661   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF000653

>  <SMILES>
O=C(c1ccco1)N1CC[C@H]2[C@H]1CC(=O)N2c1ccsc1

$$$$
SWF000654
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000654

>  <SMILES>
COCC(=O)N1CCC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF000655
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000655

>  <SMILES>
CN(C)C(=O)N1CCC[C@]2(C[C@@H](Oc3cccnc3)CO2)C1

$$$$
SWF000656
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF000656

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cnoc2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000657
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000657

>  <SMILES>
c1coc(CN2C[C@@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)c1

$$$$
SWF000658
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000658

>  <SMILES>
Cc1noc(C)c1CN1CCC2(CCC(C(=O)N(C)C)O2)CC1

$$$$
SWF000659
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 22 25  2  0  0  0  0
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  9 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000659

>  <SMILES>
c1ccc(COC2COC3(CCN(Cc4ccncc4)CC3)C2)nc1

$$$$
SWF000660
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000660

>  <SMILES>
c1ccc(O[C@H]2CO[C@@]3(CCCN(Cc4cccnc4)C3)C2)nc1

$$$$
SWF000661
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.2864    1.9677   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5561    0.7896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1958   -0.6765   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF000661

>  <SMILES>
CCOCC1CN(Cc2ccccc2F)Cc2cncn2C1

$$$$
SWF000662
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.6537   -2.0932   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5492   -1.0986   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000662

>  <SMILES>
Cc1cc(CN2CCC3(CC2)CC(OCC2CC2)CO3)no1

$$$$
SWF000663
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000663

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccc(C)cn2)C[C@@H]1Cc1ccccc1

$$$$
SWF000664
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7617    3.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6277    3.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956    2.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2617    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000664

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@H](C(=O)Nc3cccnc3)[C@@H]2C1

$$$$
SWF000665
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000665

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1COC[C@H]2CN(C3CCC3)C[C@H]21

$$$$
SWF000666
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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  8 12  2  0  0  0  0
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 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000666

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cnoc2)C[C@@H]1Cc1ccccc1

$$$$
SWF000667
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7 10  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000667

>  <SMILES>
O=C(C1CCOCC1)N1CC[C@@H]2[C@H]1CCC(=O)N2c1ccccc1

$$$$
SWF000668
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  9  5  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000668

>  <SMILES>
O=C(c1ccoc1)N1CC[C@]2(C[C@H](OCc3ccncc3)CO2)C1

$$$$
SWF000669
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000669

>  <SMILES>
Cc1nc(CO[C@@H]2CO[C@@]3(CCN(C(=O)c4cocn4)C3)C2)cs1

$$$$
SWF000670
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000670

>  <SMILES>
Cn1cc(CN2CC[C@H]3[C@@H]2CCC(=O)N3c2cccnc2)cn1

$$$$
SWF000671
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000671

>  <SMILES>
CCN1CC2(CCNCC2)COc2ccccc2S1(=O)=O

$$$$
SWF000672
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000672

>  <SMILES>
Cc1cccc(CN2C[C@@H]3COC[C@]3(CN3CCOCC3)C2)n1

$$$$
SWF000673
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.6505   -6.6646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000673

>  <SMILES>
CN(C)S(=O)(=O)N1CCC2(CC1)COC(COCC1CC1)C2

$$$$
SWF000674
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF000674

>  <SMILES>
O=C(c1ccccn1)N1C[C@H]2CCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF000675
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000675

>  <SMILES>
CCN1CCO[C@@H]2CN(Cc3cccnc3OC)CC[C@@H]2C1

$$$$
SWF000676
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000676

>  <SMILES>
CC(C)N(C)CC1CCC2(COCCN(Cc3cccs3)C2)O1

$$$$
SWF000677
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000677

>  <SMILES>
Cc1ccc(CN2CCCC3(CCN(Cc4ccoc4)CC3)C2)cc1

$$$$
SWF000678
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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 18 20  1  0  0  0  0
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 25 27  2  0  0  0  0
 11 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000678

>  <SMILES>
CNC(=O)CC1CC2(CCN(Cc3ccncc3)CC2)Oc2ccccc21

$$$$
SWF000679
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000679

>  <SMILES>
Cc1nc(CN2CCC3(CC3C(=O)N3CCCC3)C2)cs1

$$$$
SWF000680
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   15.2679    1.4728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000680

>  <SMILES>
CCO[C@@H]1CO[C@@]2(CCN(Cc3ccc4c(c3)OCO4)C2)C1

$$$$
SWF000681
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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 10 11  2  0  0  0  0
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M  END
>  <HTSID>
SWF000681

>  <SMILES>
CCC(C)N(C)C(=O)C1CCC2(CN(C(=O)c3ccco3)C2)O1

$$$$
SWF000682
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000682

>  <SMILES>
COCC1CC2(CCN(CC3CC3)CC2)CN1c1ncccn1

$$$$
SWF000683
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.7387   -3.1411   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  7  1  0  0  0  0
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  6  9  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 14  1  6  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000683

>  <SMILES>
O=C(C[C@H]1CO[C@@H]2CN(c3ccncn3)C[C@H]12)NCc1ccco1

$$$$
SWF000684
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000684

>  <SMILES>
O=C(C1CCC2(CCN(Cc3cccnc3)CC2)O1)N1CCCO1

$$$$
SWF000685
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5506   -5.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 26 27  1  0  0  0  0
 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF000685

>  <SMILES>
CNC(=O)CC1CC2(CCN(C(=O)c3ccco3)CC2)Oc2ccccc21

$$$$
SWF000686
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000686

>  <SMILES>
O=C(c1ccnnc1)N1CC[C@]2(C[C@H](OCC3CCOCC3)CO2)C1

$$$$
SWF000687
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000687

>  <SMILES>
CN1CCC2(COCCN(C(=O)CCc3ccccc3)C2)C1

$$$$
SWF000688
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 21 24  2  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000688

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCN(Cc2cccnc2)[C@H]1Cc1cccnc1

$$$$
SWF000689
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF000689

>  <SMILES>
c1cc(CO[C@H]2CC[C@H]3[C@H]2OCCN3Cc2ccoc2)ccn1

$$$$
SWF000690
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000690

>  <SMILES>
CCN1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(C)[C@H]2CC1

$$$$
SWF000691
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000691

>  <SMILES>
COc1cccc(NC(=O)C2Cn3ccnc3C3(CCN(c4ncccn4)CC3)O2)c1

$$$$
SWF000692
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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M  END
>  <HTSID>
SWF000692

>  <SMILES>
c1ccc(CN2Cc3cncn3CC(COCc3ccncc3)C2)nc1

$$$$
SWF000693
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 18 19  2  0  0  0  0
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M  END
>  <HTSID>
SWF000693

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)OC(C(=O)N1CCCCC1)Cn1ccnc12

$$$$
SWF000694
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000694

>  <SMILES>
CNC(=O)N1CCc2cc(C(=O)N3CCCC3)c(N(C)C)nc2CC1

$$$$
SWF000695
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000695

>  <SMILES>
CCC(=O)N1CCCC2(CC(C(=O)Nc3cccnc3)=NO2)C1

$$$$
SWF000696
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF000696

>  <SMILES>
Cc1nnc(N2CCCC3(CN(Cc4cccnc4)CCO3)C2)o1

$$$$
SWF000697
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  6  0  0  0
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 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000697

>  <SMILES>
CCS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(C(C)=O)C2)O1

$$$$
SWF000698
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 28 30  1  0  0  0  0
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 17 18  1  0  0  0  0
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 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000698

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCN(C(=O)c5ccoc5)CC4)nn3c2)c1

$$$$
SWF000699
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000699

>  <SMILES>
CCOCC12CCCOC1CCN(Cc1ccc(C)s1)C2

$$$$
SWF000700
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000700

>  <SMILES>
Cc1noc(C)c1CN1CC2CN(Cc3cccnc3)CC2C1

$$$$
SWF000701
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF000701

>  <SMILES>
O=C(c1cccnc1)N1C[C@@H]2CN(C(=O)c3cnccn3)C[C@@H]2C1

$$$$
SWF000702
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000702

>  <SMILES>
O=C(c1ccncc1)N1CCC(c2nc3ccc(N4CCCC4)cn3n2)CC1

$$$$
SWF000703
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000703

>  <SMILES>
O=C(c1ccccn1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)CC1

$$$$
SWF000704
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000704

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(c2ncccn2)CC3)o1

$$$$
SWF000705
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
    9.9516   -2.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000705

>  <SMILES>
c1cc(-c2ccc3nc(C4CCN(CC5CC5)CC4)nn3c2)cs1

$$$$
SWF000706
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000706

>  <SMILES>
O=C(CO[C@@H]1CC[C@H]2[C@H]1OCCN2C1CCC1)N1CCCC1

$$$$
SWF000707
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.0145    2.4885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000707

>  <SMILES>
CN(C)C(=O)C1CC2(CCCN(Cc3cccs3)C2)CO1

$$$$
SWF000708
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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    1.7617    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
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 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000708

>  <SMILES>
CCn1nc(C)cc1C(=O)N1C[C@@H]2COC[C@H](C(=O)NC)[C@@H]2C1

$$$$
SWF000709
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
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  8 12  1  0  0  0  0
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 14 10  1  1  0  0  0
 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 19 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000709

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccoc2)C1

$$$$
SWF000710
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000710

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(Cc4sccc4C)C[C@H]3O2)no1

$$$$
SWF000711
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000711

>  <SMILES>
O=C(c1cccs1)N1C[C@@H]2OCCN(c3ncccn3)[C@@H]2C1

$$$$
SWF000712
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.3147   -4.3005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
 14 17  1  1  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 14  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000712

>  <SMILES>
CO[C@H]1CCN(C(=O)C2=CCCC2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF000713
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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 13 10  1  6  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000713

>  <SMILES>
Cc1nc(CN2CC3(CCN(CC4CC4)C3)CC2=O)cs1

$$$$
SWF000714
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
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  7  9  1  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000714

>  <SMILES>
CN(C)C(=O)[C@@H]1CCO[C@@H]2CCN(Cc3cnn(C)c3)C[C@@H]21

$$$$
SWF000715
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000715

>  <SMILES>
Cc1nc(COC[C@@]23CCC[C@@H]2CN(C(=O)c2ccoc2)C3)cs1

$$$$
SWF000716
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0943   -0.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0943   -1.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  8  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000716

>  <SMILES>
O=C(c1cccs1)N1CC[C@H]2[C@H]1CCN2c1ncccn1

$$$$
SWF000717
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.8549    4.2283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2072   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000717

>  <SMILES>
c1ccc(OC[C@]23COC[C@H]2CN(Cc2ccco2)C3)nc1

$$$$
SWF000718
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000718

>  <SMILES>
C=CCN1C(=O)COC2(CCN(Cc3cnn(C)c3)CC2)C1C

$$$$
SWF000719
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000719

>  <SMILES>
O=C(Cc1cccc(F)c1)N1C[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF000720
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 11  2  0  0  0  0
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 17 15  1  6  0  0  0
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 22 25  1  0  0  0  0
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 15 16  1  0  0  0  0
 18 21  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000720

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(C(=O)NCc4cccc(F)c4)C[C@@H]32)C(=O)N1

$$$$
SWF000721
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
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 22 24  2  0  0  0  0
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 13 15  1  1  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000721

>  <SMILES>
O=C(c1cscn1)N1CCO[C@@H]2CN(Cc3ccccn3)C[C@@H]2C1

$$$$
SWF000722
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
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 10 11  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000722

>  <SMILES>
CO[C@H]1CCN(C2CCC2)[C@@H]2CN(Cc3ccncc3)C[C@H]12

$$$$
SWF000723
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  1  0  0  0
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 13 18  1  0  0  0  0
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 10 14  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000723

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccccn1)C2)c1ccccc1

$$$$
SWF000724
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  6  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000724

>  <SMILES>
Cc1cccc(C(=O)N2CC[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)n1

$$$$
SWF000725
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.9998    3.4721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9998    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6099   -0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9998    0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4998    0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814   -1.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1833   -2.9672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2498   -0.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6915   -3.1240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   13.7498   -0.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.4998    0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
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  8 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 13 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000725

>  <SMILES>
CCOC[C@]12COC[C@H]1CN(C(=O)CCc1ccccc1)C2

$$$$
SWF000726
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000726

>  <SMILES>
CCN1CCN(C)C2(CCN(Cc3nccs3)CC2)C1=O

$$$$
SWF000727
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2021  -10.4760   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6938  -10.6328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000727

>  <SMILES>
CCS(=O)(=O)N[C@H]1CCO[C@]2(CCN(Cc3ccccc3)C2)C1

$$$$
SWF000728
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2551    3.5204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9242    2.7772   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
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  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000728

>  <SMILES>
c1cncc(CO[C@H]2CC[C@H]3[C@H]2OCCN3c2ccncn2)c1

$$$$
SWF000729
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.5412   -6.4819   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2912   -5.1829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740   -6.1701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2875   -4.0682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9172   -4.6783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6414   -0.1055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0174   -1.9091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  6  1  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000729

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1CO[C@@H]2CN(Cc3ccsc3)C[C@H]12

$$$$
SWF000730
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.0203    3.8763   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5285    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7785    5.3321   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5248    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3113    5.0203   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1545    3.5285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  6  0  0  0
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 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000730

>  <SMILES>
CC(C)CN1C[C@H]2CC[C@@]3(N=C(c4ccccc4)NC3=O)[C@H]2C1

$$$$
SWF000731
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  9  6  1  1  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000731

>  <SMILES>
O=C(CC1CC1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF000732
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 17  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000732

>  <SMILES>
c1ccc(CN2C[C@H]3CCC[C@@]3(COCc3ccncc3)C2)nc1

$$$$
SWF000733
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 25 27  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000733

>  <SMILES>
CC(C)C(=O)N1CCC2(CC1)CC(CC(=O)NCC1CC1)c1ccccc12

$$$$
SWF000734
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 10 13  1  0  0  0  0
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 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000734

>  <SMILES>
O=C([C@@H]1C[C@@H]2CCN(Cc3ccco3)C[C@H]2O1)N1CCCCO1

$$$$
SWF000735
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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    2.7546   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0537   -5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
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  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000735

>  <SMILES>
CO[C@H]1CCN(Cc2nc(C)cs2)[C@@H]2CN(CC3CC3)C[C@H]12

$$$$
SWF000736
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000736

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccoc2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000737
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   10.3102    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6411    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8102    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8321    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0819    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8910    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000737

>  <SMILES>
O=C(C[C@H]1C[C@H]2CN(Cc3ccsc3)C[C@H]2O1)NCc1cccnc1

$$$$
SWF000738
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5981    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3776    0.9067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5686   -0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0468    0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5468   -0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF000738

>  <SMILES>
CN(C)C(=O)NCC1CC12CCN(C(=O)c1ccno1)CC2

$$$$
SWF000739
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846   -6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0827   -5.8198   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8444   -8.6730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0864   -6.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2298   -8.7718   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6228   -8.3611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5536   -6.6227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6196  -10.1421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7215   -8.6150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  6  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000739

>  <SMILES>
CCC(=O)N1CCC2(CC1)CC(N(C)C)c1ccc(C)cc12

$$$$
SWF000740
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7942   -6.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    3.7172   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    3.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    2.5037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3152    2.1918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517    0.7652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  6  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000740

>  <SMILES>
CCn1nnc2c1C(COC)CN(Cc1ccc(F)cc1)C2

$$$$
SWF000741
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    8.8531   -0.1872   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7383    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8951    2.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5248    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000741

>  <SMILES>
CC(C)CN1C[C@@H]2C(=O)N(C)C3(CCN(C(=O)c4ccccc4)CC3)[C@@H]2C1

$$$$
SWF000742
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000742

>  <SMILES>
O=C(c1ccccn1)N1C[C@H](Oc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF000743
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 10 11  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000743

>  <SMILES>
CC(C)C(=O)NC1COC2(CCN(Cc3cnn(C)c3)CC2)C1

$$$$
SWF000744
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000744

>  <SMILES>
O=C(Cc1ccccn1)N1CCC2(CC(Oc3cccnc3)CO2)C1

$$$$
SWF000745
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000745

>  <SMILES>
CN1C(=O)CC2(CCN(Cc3cnn(C)c3)CC2)c2ccccc21

$$$$
SWF000746
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000746

>  <SMILES>
CN(C)C(=O)C1COC2(CCN(Cc3cnn(C)c3)CC2)C1

$$$$
SWF000747
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 13 16  1  0  0  0  0
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 17 20  1  0  0  0  0
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 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000747

>  <SMILES>
CC(=O)N1CCOCC2(CCCN(Cc3csc(C)n3)C2)C1

$$$$
SWF000748
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  6  0  0  0
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 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000748

>  <SMILES>
Cc1nnc(N2C[C@@H]3[C@H](CC(=O)Nc4cccnc4)CO[C@@H]3C2)s1

$$$$
SWF000749
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
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M  END
>  <HTSID>
SWF000749

>  <SMILES>
Cc1nc(COC[C@]23COC[C@H]2CN(c2ncccn2)C3)cs1

$$$$
SWF000750
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000750

>  <SMILES>
O=C(c1ccoc1)N1CCC[C@]2(C(=O)O)CN(c3ccccn3)C[C@@H]2C1

$$$$
SWF000751
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  1  0  0  0
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 13 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000751

>  <SMILES>
O=S(=O)(N[C@@H]1CCO[C@]2(CCN(C3CCC3)C2)C1)c1ccccc1

$$$$
SWF000752
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000752

>  <SMILES>
O=C(c1ccnnc1)N1CC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF000753
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.7221   -5.1517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -6.4508   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2221   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000753

>  <SMILES>
O=C([C@H]1COC[C@H]2CN(Cc3ccco3)C[C@H]21)N1CCOCC1

$$$$
SWF000754
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.6721   -1.2275   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3335   -5.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4354   -3.6546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2152   -6.3952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3171   -4.8681   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000754

>  <SMILES>
Cn1cc(CN2CCC3(CC2)CCN(C(=O)c2cnccn2)C3)cn1

$$$$
SWF000755
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.7013    1.4872   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6407    2.5478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6145    2.6772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8243   -2.0164   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3243   -4.6145   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 11 18  1  0  0  0  0
 11 19  1  0  0  0  0
 13 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 15  1  0  0  0  0
 14 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000755

>  <SMILES>
CCN1CCC2(CC1)COc1ccccc1S(=O)(=O)N(CC(C)C)C2

$$$$
SWF000756
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    6.8986    1.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7646    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
>  <HTSID>
SWF000756

>  <SMILES>
CN(C)C(=O)COC[C@]12COC[C@H]1CN(S(C)(=O)=O)C2

$$$$
SWF000757
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000757

>  <SMILES>
O=C(NCc1cccnc1)[C@@H]1CN(c2ncccn2)C[C@H]2OCC[C@H]21

$$$$
SWF000758
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000758

>  <SMILES>
Cc1cc(CN2C[C@@H]3COC[C@]3(CNS(C)(=O)=O)C2)no1

$$$$
SWF000759
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000759

>  <SMILES>
O=C(c1cocn1)N1CC[C@]2(C[C@@H](Oc3cccnc3)CO2)C1

$$$$
SWF000760
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000760

>  <SMILES>
O=C(c1ccco1)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF000761
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12  9  1  1  0  0  0
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 20 24  2  0  0  0  0
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 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF000761

>  <SMILES>
O=C(NCCc1ccccn1)[C@@H]1C[C@H]2OCC[C@H]2N(CC2CC2)C1

$$$$
SWF000762
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 12 10  1  1  0  0  0
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 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 14 13  1  1  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000762

>  <SMILES>
Cc1noc(C)c1CN1CC[C@H]2[C@H](CO[C@H]2CNc2ncccn2)C1

$$$$
SWF000763
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0692    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000763

>  <SMILES>
CCS(=O)(=O)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF000764
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000764

>  <SMILES>
COCC(=O)NC[C@]12COC[C@H]1CN(Cc1cccnc1)C2

$$$$
SWF000765
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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 11  8  1  1  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000765

>  <SMILES>
O=C(NCCC1CCOC12CN(C1CCC1)C2)c1cccnc1

$$$$
SWF000766
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  6  8  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000766

>  <SMILES>
O=C(N[C@@H]1CCO[C@]2(CCN(C3CCC3)C2)C1)c1ccsc1

$$$$
SWF000767
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3007   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  7 11  1  0  0  0  0
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 14 16  1  1  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000767

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccnn2C)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000768
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    5.2348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    5.2348   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9579   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.1165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2570    5.6984   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1423    4.6947   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2843    5.1582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4542    3.2275   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3990    4.1545   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6606    2.2238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0871    2.6873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 14 18  1  0  0  0  0
 15 16  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000768

>  <SMILES>
Cn1ccnc1CNC(=O)[C@H]1C[C@H]2[C@H](CCN2Cc2cccnc2)O1

$$$$
SWF000769
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.3245    2.3625   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2554    1.9972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9884    2.6774   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9773    2.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6937    3.6329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1564    0.4367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4773    1.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7188    3.8555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 10 12  2  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000769

>  <SMILES>
CCN1Cc2ccccc2CC2(CCN(CC(=O)O)CC2)C1=O

$$$$
SWF000770
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 23 26  1  0  0  0  0
 23 27  2  0  0  0  0
 26 28  3  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 22 25  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000770

>  <SMILES>
CN(Cc1cccnc1)C1COC2(CCN(Cc3cccc(C#N)c3)CC2)C1

$$$$
SWF000771
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.2847   -3.9169   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 12  1  1  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000771

>  <SMILES>
CS(=O)(=O)N1CCO[C@@H]2CN(C(=O)c3ccnnc3)C[C@@H]2C1

$$$$
SWF000772
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  1  6  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 18 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000772

>  <SMILES>
CN1CC[C@@]2(C(=O)N3CCCC3)CCN(C(=O)c3ccccc3)CC[C@@H]12

$$$$
SWF000773
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  6  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000773

>  <SMILES>
O=C([C@@H]1C[C@H]2OCC[C@H]2N(Cc2ccccc2F)C1)N1CCCCO1

$$$$
SWF000774
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000774

>  <SMILES>
Cc1nc([C@@H]2C[C@H]3CN(C(=O)c4sccc4C)C[C@H]3O2)no1

$$$$
SWF000775
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.7054    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000775

>  <SMILES>
Cc1noc(C)c1CN1C[C@@H]2COC[C@]2(COCC2CCC2)C1

$$$$
SWF000776
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000776

>  <SMILES>
Cc1ncsc1CN1CC[C@]2(CCC[C@@H](CN3CCCC3=O)O2)C1

$$$$
SWF000777
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.3818    3.7433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000777

>  <SMILES>
CC(C)CN1CCCC2(CCN(C(=O)c3ccccn3)C2)C1

$$$$
SWF000778
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
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 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000778

>  <SMILES>
O=C(C1CCOCC1)N1C[C@@H]2COC[C@]2(COCc2cccnc2)C1

$$$$
SWF000779
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    8.3492    4.1310   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2845    5.3037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8012    5.5272   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3679    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8956    4.7884   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8279    4.1310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1179    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0521    1.1393   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1794    3.4801   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  1  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000779

>  <SMILES>
CCN1[C@H]2CCN(C(=O)NC)CC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF000780
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.2759   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 11  1  1  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000780

>  <SMILES>
O=C(C1CCOC1)N1C[C@H]2CN(c3cccnc3)C(=O)[C@H]2C1

$$$$
SWF000781
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7628   -1.1466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7440   -0.9533   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8300    1.0994   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2046   -0.0658   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000781

>  <SMILES>
CC(=O)N1C[C@@H]2CN(Cc3cnn(C)c3)CCC[C@]2(C(=O)O)C1

$$$$
SWF000782
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.8820   -5.2379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000782

>  <SMILES>
O=C(C1CCC2(CCN(Cc3ccccc3F)CC2)O1)N1CCCO1

$$$$
SWF000783
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  7  1  6  0  0  0
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 10 15  1  6  0  0  0
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 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 10 11  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000783

>  <SMILES>
COc1cc(C)ccc1S(=O)(=O)N1C[C@@H]2C[C@@H](C)O[C@@H]2C1

$$$$
SWF000784
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000784

>  <SMILES>
COCC(=O)N1CCCC2(COCCN(c3cccnc3)C2)C1

$$$$
SWF000785
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000785

>  <SMILES>
c1cnc(N2CCC3(CC2)CC(N2CCOCC2)CO3)nc1

$$$$
SWF000786
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.9679    2.3614   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000786

>  <SMILES>
CS(=O)(=O)N1CCO[C@H]2[C@@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF000787
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000787

>  <SMILES>
CCS(=O)(=O)NC1COCCC12CCN(Cc1cccnc1)CC2

$$$$
SWF000788
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000788

>  <SMILES>
CCS(=O)(=O)N1CCC2(CC1)CN(Cc1cccnc1)CC21CCNC1=O

$$$$
SWF000789
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000789

>  <SMILES>
O=S(=O)(C1CC1)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF000790
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF000790

>  <SMILES>
Cn1cc(C(=O)N[C@@H]2CCO[C@]3(CCN(Cc4ccncc4)C3)C2)cn1

$$$$
SWF000791
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 22 24  2  0  0  0  0
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 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000791

>  <SMILES>
O=C([C@H]1C[C@@H]2CCN(Cc3ccccc3)C[C@H]2O1)N1CCCCO1

$$$$
SWF000792
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000792

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)Cc1cccs1)CC2

$$$$
SWF000793
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7942    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000793

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)c3cccnc3)C2)CC1

$$$$
SWF000794
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.0351   -4.6476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000794

>  <SMILES>
O=C1NCCO[C@H]2CN(C(=O)c3cnc4ccccc4c3)CC[C@@H]12

$$$$
SWF000795
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000795

>  <SMILES>
Cc1cccc(COC2COC3(CCN(C(=O)CC4CC4)CC3)C2)n1

$$$$
SWF000796
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000796

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(C1CCC1)C2)c1ccnnc1

$$$$
SWF000797
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000797

>  <SMILES>
Cn1cc2c(n1)C(COCC1CC1)CN(C(=O)Cc1ccccn1)C2

$$$$
SWF000798
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 14 10  1  1  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000798

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@H]2OCC[C@H]2N(Cc2ccncc2)C1

$$$$
SWF000799
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
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 23 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000799

>  <SMILES>
Cn1ccnc1CN1CCC2(CC1)CCN(C(=O)Cc1ccccc1)C2

$$$$
SWF000800
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000800

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(Cc4cccnc4)C[C@@H]32)C(=O)N1CC1CC1

$$$$
SWF000801
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
    3.5864   -6.1504   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7641   -3.7509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6669   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0841   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.7101   -4.6706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   15.0509   -3.5433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000801

>  <SMILES>
CC(C)CC(=O)N1CCN(C(=O)Nc2ccccc2)CC2(CC(=O)N(C)C2)C1

$$$$
SWF000802
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3931    4.6744   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8518    4.1342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.5078    5.6781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000802

>  <SMILES>
COCCN1CC[C@]2(CN(Cc3cccc(C)n3)C[C@H]2C)C1=O

$$$$
SWF000803
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000803

>  <SMILES>
O=C(N1CCCC1)N1CC2(CCN(Cc3cccnc3)C2)C1

$$$$
SWF000804
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
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  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000804

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@@H](OCc4ccncc4)CC[C@@H]32)no1

$$$$
SWF000805
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000805

>  <SMILES>
O=C([C@@H]1CCO[C@@H]2CCN(C3CCCC3)C[C@H]21)N1CCCO1

$$$$
SWF000806
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
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  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000806

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(C(=O)C3CC3)C2)O1

$$$$
SWF000807
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000807

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1CCO[C@@H]2CCN(C3CCOCC3)C[C@H]21

$$$$
SWF000808
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.7831    4.7614   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3818    3.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0195    2.7253   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5628    2.0208   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000808

>  <SMILES>
CC(C)CN1CCCC2(CCN(C(=O)Cc3ccccn3)C2)C1

$$$$
SWF000809
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6002    3.5843   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2693    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1002    4.4503   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0614    1.8630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0783    4.2424   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8046    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000809

>  <SMILES>
Cc1cccc(CN2C(=O)CCC23CCN(c2nccs2)CC3)c1

$$$$
SWF000810
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 14 10  1  6  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000810

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1CO[C@H]2CCN(C3CCCC3)C[C@H]2C1

$$$$
SWF000811
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7511   -2.2908   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5307   -2.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000811

>  <SMILES>
Cc1nc(CN2C[C@H](OCc3cccnc3)[C@H]3OCCC[C@H]32)cs1

$$$$
SWF000812
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2501    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4673    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7210    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  8  1  1  0  0  0
 12  9  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000812

>  <SMILES>
COCCNC(=O)C[C@@H]1C[C@H]2CN(Cc3ccncc3)C[C@H]2O1

$$$$
SWF000813
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 16 20  2  0  0  0  0
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 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000813

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@@H](OCc4cccnc4)CC[C@@H]32)no1

$$$$
SWF000814
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000814

>  <SMILES>
Fc1ccc(-c2ncnc3c2CCN(C2CCOC2)CC3)cc1

$$$$
SWF000815
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000815

>  <SMILES>
O=C(CC1CC1)NC[C@]12COC[C@H]1CN(CCc1ccccc1)C2

$$$$
SWF000816
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 21 22  1  0  0  0  0
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 11 14  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000816

>  <SMILES>
O=S(=O)(NCC1CN(C2CCC2)Cc2ccnn21)c1ccccc1

$$$$
SWF000817
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
   11.3566   -1.3361   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6282    1.2478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0180    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1748    4.1099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8045    3.4998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 16 19  2  0  0  0  0
 17 20  1  6  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF000817

>  <SMILES>
O=C(CC1CC1)N1CCC2(CC1)CC(CC(=O)N1CCCC1)c1ccccc12

$$$$
SWF000818
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    7.7942   -2.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2942   -2.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2942   -1.1340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  6  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000818

>  <SMILES>
C=CCOCC1CN(C(=O)CS(C)(=O)=O)Cc2nnn(C)c21

$$$$
SWF000819
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13 11  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000819

>  <SMILES>
O=C([C@@H]1C[C@H]2OCC[C@H]2N(Cc2ccncc2)C1)N1CCCC1

$$$$
SWF000820
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.1172    1.1997   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2218    0.2052   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0127    2.1943   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1118    1.3043   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  1  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000820

>  <SMILES>
CS(=O)(=O)N[C@H]1CCO[C@]2(CCN(C(=O)c3ccccn3)C2)C1

$$$$
SWF000821
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
   10.3923   -5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5070    0.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000821

>  <SMILES>
CN(C)CCOCC1CN(C(=O)[C@H]2CCCO2)Cc2nnn(C)c21

$$$$
SWF000822
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.3818    3.7433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7831    4.7614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7612    4.9693   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2831    5.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657    5.9638   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5043    4.3002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9522    6.3706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7443    7.3487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000822

>  <SMILES>
Cc1cc(C(=O)N2CCC3(CCCN(CC(C)C)C3)C2)c(C)o1

$$$$
SWF000823
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2709   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2709   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8587   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8587   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8097   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8097   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6188    0.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0255    1.0013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6133    0.1923   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000823

>  <SMILES>
O=C(c1cccs1)N1CC[C@H]2C[C@H](c3nnc(C4CC4)o3)O[C@@H]2C1

$$$$
SWF000824
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2556   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7226   -3.3966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0316   -4.3477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0097   -4.5556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.6157   -4.8829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0023   -6.7850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2848   -5.6261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9758   -6.5771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000824

>  <SMILES>
CS(=O)(=O)NC[C@@H]1OC[C@H]2CN(C(=O)c3ccnnc3)CC[C@H]21

$$$$
SWF000825
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.8944   -1.7889   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5887   -1.0351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4311    0.4644   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2114   -1.6483   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9564    0.7778   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5515    1.4732   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8340   -2.2615   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2202   -2.7687   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2711   -0.4858   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6970   -0.8379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5284   -3.0153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9916   -3.7609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4664   -4.0744   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5284    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2227   -2.2615   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0796   -5.4517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2227   -0.7538   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1934   -6.6714   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.5790   -5.6093   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9170   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8066   -8.0487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1922   -6.9866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9170    1.5077   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6113   -0.7538   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3060   -8.2063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3057   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7538   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000825

>  <SMILES>
COCC(=O)N1CCC2(CC1)CN(c1ncccn1)CC21CCN(C)C1=O

$$$$
SWF000826
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0118   -5.5037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9099   -6.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4017   -6.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 14 10  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000826

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1C[C@H]2OCC[C@H]2N(Cc2ccncc2)C1

$$$$
SWF000827
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.7071    3.3815   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.3004    2.4680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7017    3.2770   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0435    1.7989   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF000827

>  <SMILES>
CC(C)COC[C@@H]1CC[C@H]2[C@H](CCN2Cc2nccs2)O1

$$$$
SWF000828
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6530   -2.3227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000828

>  <SMILES>
Cc1occc1C(=O)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF000829
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000829

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@H](C(=O)N4CCCC4)O[C@H]3C2)nn1

$$$$
SWF000830
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   11.4436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000830

>  <SMILES>
COc1cccc(CN2CCC3(CC2)CCN(C(=O)C2CC=CC2)C3)c1

$$$$
SWF000831
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  4  9  1  1  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000831

>  <SMILES>
c1cncc(OC[C@@H]2CCC[C@@]23CN(Cc2ccco2)CCO3)c1

$$$$
SWF000832
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 22 25  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000832

>  <SMILES>
O=C(c1ccoc1)N1CC[C@]2(C1)C(=O)NC[C@H]2COc1ccccn1

$$$$
SWF000833
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.0234   -3.0984   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2459   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2209   -1.9010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6547   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2459    0.1235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000833

>  <SMILES>
Cc1cc(C(=O)N2CC[C@H]3C(=O)NCCO[C@H]3C2)cc(C)n1

$$$$
SWF000834
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    7.7054    1.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
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 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000834

>  <SMILES>
O=C(c1ccsc1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF000835
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000835

>  <SMILES>
O=C(NC1CCCC1)[C@@H]1C[C@@H]2CCN(C3CCOCC3)C[C@@H]2O1

$$$$
SWF000836
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
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 11 10  1  6  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 14 18  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000836

>  <SMILES>
O=C(COC[C@@]12CCC[C@@H]1CN(Cc1ccco1)C2)N1CCCC1

$$$$
SWF000837
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    9.0413   -2.6730   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6400   -3.4820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 12  1  1  0  0  0
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 14 16  1  1  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000837

>  <SMILES>
O=C(NCC1CC1)[C@@H]1C[C@@H]2CCN(Cc3nccs3)C[C@@H]2O1

$$$$
SWF000838
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7414   -1.5928   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6977   -1.1770   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9274   -2.3630   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4431    1.7829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0611    1.7829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2521    2.3707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000838

>  <SMILES>
COCC1CCC2(CCN(C(=O)N3CCCC3)CC2)N1S(C)(=O)=O

$$$$
SWF000839
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  3  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000839

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(C(=O)c1ccoc1)CC2

$$$$
SWF000840
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8425   -1.1499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4252   -0.8135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3425   -2.0159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206   -1.8080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9358   -2.9295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5235   -3.7385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2145   -4.6895   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5235   -3.7385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0235   -5.2773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8326   -4.6895   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000840

>  <SMILES>
O=C1NC[C@H](COc2ccccn2)[C@]12CCN(Cc1ccoc1)C2

$$$$
SWF000841
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    2.5933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    3.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812    1.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812   -0.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8690    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 12 13  2  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000841

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@H]2OCC[C@H]2N(C(=O)c2ccco2)C1

$$$$
SWF000842
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   12.0626   -4.7658   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.2194   -3.2740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4329   -4.1557   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.7570   -1.8736   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8190   -2.7365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9392    2.4955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000842

>  <SMILES>
COCC1CC2(CCN(C(=O)C3CC(F)(F)C3)CC2)CN1C

$$$$
SWF000843
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    1.8605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8717    2.6037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6638    3.5818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4070    4.2510   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7128    3.8909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF000843

>  <SMILES>
N#Cc1cccc(OC[C@@H]2CO[C@@H]3CN(c4cnccn4)C[C@H]23)c1

$$$$
SWF000844
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000844

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3OCC[C@@]3(c3nnc(C)o3)C2)cn1

$$$$
SWF000845
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF000845

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(Cc2ccoc2)C3)cs1

$$$$
SWF000846
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.0622    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000846

>  <SMILES>
CS(=O)(=O)N1C[C@H](C(=O)NCc2ccco2)C[C@H]2OCC[C@H]21

$$$$
SWF000847
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF000847

>  <SMILES>
O=C(c1cccs1)N1CCCC2(CCN(Cc3ccncc3)C2)C1

$$$$
SWF000848
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000848

>  <SMILES>
Cc1noc([C@H]2C[C@H]3CN(C(=O)Cc4ccccn4)CC[C@H]3O2)n1

$$$$
SWF000849
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 24 27  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000849

>  <SMILES>
O=C(NCC1CC1)[C@@]12CCCN(Cc3ccncc3)C[C@H]1CN(c1ncccn1)C2

$$$$
SWF000850
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.7432   -5.1073   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.9932   -6.4063   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -6.4063   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4442   -4.3573   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0423   -4.3573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.5423   -4.3573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 11  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000850

>  <SMILES>
O=S(=O)(C1CC1)N1CC[C@]2(C[C@@H](OCCN3CCCC3)CO2)C1

$$$$
SWF000851
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.3323   -1.0671   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 12 10  1  1  0  0  0
 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF000851

>  <SMILES>
COc1ccc(C(=O)N2C[C@H]3C[C@H]4[C@](C2)(CN(C)S4(=O)=O)O3)cc1

$$$$
SWF000852
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.1941   -3.1386   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  1  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000852

>  <SMILES>
Fc1cnc(N2CCC[C@]3(C[C@@H](Oc4ccccn4)CO3)C2)nc1

$$$$
SWF000853
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.8336    2.2223   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 10  1  6  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000853

>  <SMILES>
Cc1nnc(C[C@@H]2OC[C@H]3CN(C(=O)c4ccccc4)CC[C@H]32)[nH]1

$$$$
SWF000854
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  2  0  0  0  0
 21 17  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000854

>  <SMILES>
O=C([C@H]1CCCO1)N1CCC2(CCC(=O)N2CCN2CCCC2)CC1

$$$$
SWF000855
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 12  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000855

>  <SMILES>
COCC12CCCOC1CCN(C(=O)Cc1ccccc1C)C2

$$$$
SWF000856
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.0993    2.2231   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7684    2.9663   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4301    1.4800   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3561    2.8923   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6345    0.5759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    1.8630   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3287    0.2158   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000856

>  <SMILES>
CS(=O)(=O)N1CCO[C@]2(CCC[C@@H]2COCc2ccccn2)C1

$$$$
SWF000857
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3190    1.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7203    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7258    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2258    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7258    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7258    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7258    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7258    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2258    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000857

>  <SMILES>
COCCNC(=O)C[C@@H]1COC[C@H]2CN(Cc3ccccc3)C[C@@H]12

$$$$
SWF000858
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0280   -1.7788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -3.9899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2359   -0.8006   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7712   -2.4479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -3.9899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000858

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(Cc3cnn(C)c3)C[C@H]2N1C(C)C

$$$$
SWF000859
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    7.5547    2.9831   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5765    3.1911   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6592    1.9886   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0765    2.3250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7457    1.5819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000859

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(CC(=O)O)C2

$$$$
SWF000860
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  7  6  1  6  0  0  0
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  7  9  1  0  0  0  0
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  8 11  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000860

>  <SMILES>
CS(=O)(=O)NC[C@]12COC[C@H]1CN(C(=O)c1cccnc1)C2

$$$$
SWF000861
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000861

>  <SMILES>
C1COC2CCN(C3CCOCC3)CC2(COCC2CC2)C1

$$$$
SWF000862
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -4.7709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2321   -8.2350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000862

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1C[C@@H]2CCN(Cc3cccnc3)C[C@H]2O1

$$$$
SWF000863
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393    0.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  6  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000863

>  <SMILES>
CN(C)C(=O)N1Cc2ncn(C)c2C(COCC2CCOCC2)C1

$$$$
SWF000864
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.1240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000864

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@@H](C(=O)N4CCCCO4)O[C@@H]3C2)nn1

$$$$
SWF000865
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000865

>  <SMILES>
c1cncc(CO[C@H]2CC[C@H]3[C@@H]2OCCN3Cc2ccsc2)c1

$$$$
SWF000866
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000866

>  <SMILES>
O=C(NCc1ccco1)[C@H]1CC[C@@H]2[C@@H](CCN2c2ncccn2)O1

$$$$
SWF000867
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  6  0  0  0
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 17 19  1  0  0  0  0
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 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000867

>  <SMILES>
Cc1ccc(N2CC[C@H]3O[C@H](C(=O)NCc4ccco4)CC[C@H]32)nn1

$$$$
SWF000868
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000868

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CC1)CCN(CC1CC1)C2=O

$$$$
SWF000869
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000869

>  <SMILES>
CO[C@@H]1CO[C@@]2(CCN(C(=O)COc3ccccc3C)C2)C1

$$$$
SWF000870
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000870

>  <SMILES>
Cc1ccc(CN2CC[C@H]3OCC[C@@]3(CCNC(=O)C3CC3)C2)s1

$$$$
SWF000871
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5897   -1.4575   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.9600   -0.8474   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6282    1.2478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.9985    1.8579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7850    2.7395   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000871

>  <SMILES>
O=S(=O)(C1CC1)N1CCC2(CC1)CC(OCc1ccncc1)CO2

$$$$
SWF000872
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.7824    6.3424   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6425    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000872

>  <SMILES>
O=C(NC1CC(F)(F)C1)[C@]12COC[C@H]1CN(Cc1cccs1)C2

$$$$
SWF000873
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   16.1600   -4.0095   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   14.6682   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.9182   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  8 10  1  0  0  0  0
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 13 15  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF000873

>  <SMILES>
COCCNC(=O)[C@H]1C[C@@H]2CCN(Cc3nccs3)C[C@H]2O1

$$$$
SWF000874
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000874

>  <SMILES>
CN(C)C(=O)N[C@@H]1CCO[C@]2(CCN(c3ncccn3)C2)C1

$$$$
SWF000875
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.9428   -2.1548   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1996   -2.8239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  6  0  0  0
 14 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000875

>  <SMILES>
COc1cccc(C(=O)N2C[C@@H](N3CCCC3=O)[C@H]3OCCC[C@H]32)c1

$$$$
SWF000876
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000876

>  <SMILES>
CN(C)C(=O)COCC12CCCOC1CCN(CC1CC1)C2

$$$$
SWF000877
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000877

>  <SMILES>
CO[C@H]1CCN(Cc2ccco2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF000878
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.7543    2.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 22 24  2  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000878

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1cccs1)C2)c1ccnnc1

$$$$
SWF000879
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000879

>  <SMILES>
c1cnc(N2CCC3(CCOCC3COCC3CC3)CC2)nc1

$$$$
SWF000880
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000880

>  <SMILES>
Cc1oncc1C(=O)N1CCO[C@H]2[C@@H](OCC3CC3)CC[C@@H]21

$$$$
SWF000881
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000881

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@@H](C(=O)NCc4ccccn4)O[C@@H]3C2)nn1

$$$$
SWF000882
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000882

>  <SMILES>
CO[C@@H]1CCN(Cc2ccc(C)o2)[C@@H]2CN(Cc3cccnc3)C[C@@H]21

$$$$
SWF000883
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.5135    4.9687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0500    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  1  0  0  0
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 11 14  1  0  0  0  0
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 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF000883

>  <SMILES>
Cc1ccc(C(=O)N2CCO[C@H]3[C@H](OCCN(C)C)CC[C@@H]32)o1

$$$$
SWF000884
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -2.7654  -11.7849   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000884

>  <SMILES>
CCN(CC)[C@H]1CCO[C@]2(CCN(c3ncc(F)cn3)C2)C1

$$$$
SWF000885
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000885

>  <SMILES>
N#Cc1ccc(OC[C@]23COC[C@H]2CN(C(=O)c2ccco2)C3)nc1

$$$$
SWF000886
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000886

>  <SMILES>
Cc1ccc(N2C[C@H](C)[C@]3(CCN(c4ccsc4)C3=O)C2)nn1

$$$$
SWF000887
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   12.5768   -4.0767   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000887

>  <SMILES>
O=C(C1CCSCC1)N1CCC2(CC1)CC(OCC1CC1)CO2

$$$$
SWF000888
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  6  0  0  0
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 11 16  1  0  0  0  0
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 13 18  1  6  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000888

>  <SMILES>
CCN1C[C@H]2[C@@H](C1)N(C(=O)Cc1ccccc1)CC[C@H]2OC

$$$$
SWF000889
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.2277   -5.4753   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8011   -5.0118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4892   -3.5445   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6864   -6.0155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0627   -3.0810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2192   -5.7036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8432   -7.5072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2921   -1.0736   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7508   -1.6138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4692   -7.0026   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8692    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000889

>  <SMILES>
CCOCCC1CCOC12CCN(C(=O)c1occc1C)CC2

$$$$
SWF000890
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0686    1.0365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9218    1.0365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0686    3.4635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9218    3.4635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1869    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3035    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0535    3.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5535    3.5490   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   13.3035    4.8481   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0535    6.1471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5535    6.1471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  1  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000890

>  <SMILES>
COCCNC(=O)[C@]12COC[C@H]1CN(Cc1ccccn1)C2

$$$$
SWF000891
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 12 18  2  0  0  0  0
 17 19  2  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 15  1  0  0  0  0
 13 18  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000891

>  <SMILES>
O=C([C@H]1C[C@H]2OCC[C@H]2N(C(=O)c2cnccn2)C1)N1CCCCO1

$$$$
SWF000892
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.8974   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2072   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005   -1.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000892

>  <SMILES>
O=C(c1cocn1)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF000893
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    4.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000893

>  <SMILES>
Cc1ccnc(OC[C@]23COC[C@H]2CN(C(=O)c2ccoc2)C3)n1

$$$$
SWF000894
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000894

>  <SMILES>
Cc1cc(CN2CC[C@H]3C[C@@H](C(=O)NCc4cccnc4)O[C@@H]3C2)no1

$$$$
SWF000895
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000895

>  <SMILES>
c1ccc(CN2CCC3(CC2)CN(Cc2cccnc2)CCO3)nc1

$$$$
SWF000896
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000896

>  <SMILES>
Cc1cc(CN2CC[C@H]3C[C@H](C(=O)NCc4ccco4)O[C@@H]3C2)no1

$$$$
SWF000897
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0023   -6.7850   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6496   -6.2498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2848   -5.6261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9758   -6.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3114   -7.7361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9586   -7.2009   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2895   -7.9440   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000897

>  <SMILES>
CN(C)C(=O)C[C@@H]1OC[C@H]2CN(Cc3cccc4ccccc34)CC[C@H]21

$$$$
SWF000898
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8936    2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4110    3.4797   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8071    1.9890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1020    4.4308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4110    3.4797   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  1  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000898

>  <SMILES>
CCN1C[C@@H](COC)[C@]2(CCN(C(=O)CC3CCCC3)C2)C1

$$$$
SWF000899
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000899

>  <SMILES>
Cc1cccc(CN2C(=O)C[C@@H]3[C@@H]2CCN3Cc2ccccn2)n1

$$$$
SWF000900
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000900

>  <SMILES>
O=C(c1ccccn1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF000901
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000901

>  <SMILES>
COCC1Cn2nnc(-c3cnn(C)c3)c2CN1Cc1cnn(C)c1

$$$$
SWF000902
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000902

>  <SMILES>
O=C(N1CCCC1)N1CCOC2C(Cn3cnnc3)CCC21

$$$$
SWF000903
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9473   -3.3565   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9510   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1682   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3490   -4.2921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
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 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000903

>  <SMILES>
CN(C)CCOCC1CCC2C1OCCN2Cc1ccncc1

$$$$
SWF000904
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3508    1.8499   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1599    1.2621   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5418    2.4377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9386    2.6589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000904

>  <SMILES>
CS(=O)(=O)N1CCC[C@]2(C[C@H](OCc3cccnc3)CO2)C1

$$$$
SWF000905
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.5492   -1.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  6  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000905

>  <SMILES>
c1coc(CN2CCC3(CC2)CC(OCC2CCC2)CO3)c1

$$$$
SWF000906
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
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 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000906

>  <SMILES>
CN(C)CC(=O)N1CCC2(CC1)CC(OCc1ccncc1)CO2

$$$$
SWF000907
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000907

>  <SMILES>
O=C(c1ccsc1)N1CCC2(CC1)COC(COc1ccccn1)C2

$$$$
SWF000908
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 13  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000908

>  <SMILES>
O=C(CC1CC1)N1CCC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF000909
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0314   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000909

>  <SMILES>
O=C(C1CC=CC1)N1C[C@H]2CN(Cc3cccc(F)c3)C[C@H]2C1

$$$$
SWF000910
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    8.9280    2.0818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000910

>  <SMILES>
Cc1cccc(CO[C@@H]2CO[C@@]3(CCCN(Cc4ccoc4)C3)C2)n1

$$$$
SWF000911
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000911

>  <SMILES>
O=C(c1cnoc1)N1CCC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF000912
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 11  1  6  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000912

>  <SMILES>
CN(C)C(=O)CO[C@H]1CO[C@@]2(CCCN(Cc3ccoc3)C2)C1

$$$$
SWF000913
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684    1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3037    0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.3037    0.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  1  0  0  0
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 11 15  1  0  0  0  0
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 24 25  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000913

>  <SMILES>
COc1ccc(CN2C[C@@H]3COC[C@]3(CC(=O)N3CCCO3)C2)cc1

$$$$
SWF000914
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.3454    1.7454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9441    2.7635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000914

>  <SMILES>
CCC(=O)N1CCC[C@]2(C[C@H](OCc3ccncc3)CO2)C1

$$$$
SWF000915
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2105   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6172   -3.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1172   -4.6046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5954   -3.9465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7864   -5.3478   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000915

>  <SMILES>
Cn1cc(C(=O)N2CCC[C@]3(C[C@H](Oc4cccnc4)CO3)C2)cn1

$$$$
SWF000916
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.2565   -4.1450   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5556   -3.3950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8582   -3.1413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2437   -1.9278   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2481   -1.7710   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9826   -1.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  1  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000916

>  <SMILES>
c1csc(CN2CC[C@H]3OCC[C@@]3(COCc3ccncc3)C2)c1

$$$$
SWF000917
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0926    2.4343   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6804    3.2433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0816    2.2253   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4939    1.4162   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  1  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  6  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  8  9  1  0  0  0  0
 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000917

>  <SMILES>
Cc1ccc(OCC(=O)N2CC[C@]3(CCC[C@H](CN(C)C)O3)C2)cc1

$$$$
SWF000918
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    4.8974   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    4.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8005   -1.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000918

>  <SMILES>
c1cncc(OC[C@]23COC[C@H]2CN(Cc2ccoc2)C3)c1

$$$$
SWF000919
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    4.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8660    6.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    7.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF000919

>  <SMILES>
Cn1cccc1C(=O)N1CCC(c2nc3ccc(-c4ccccc4)cn3n2)CC1

$$$$
SWF000920
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7550    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5640    0.7696   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0640   -0.7692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3731    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0640   -0.7692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 13 10  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000920

>  <SMILES>
O=C1N(Cc2cccc(F)c2)CCC12CCN(Cc1ccoc1)C2

$$$$
SWF000921
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.1295    3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    0.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    0.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    0.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615   -0.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000921

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)c3cccc(C)n3)C[C@H]2N1C

$$$$
SWF000922
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000922

>  <SMILES>
CCOCC12CCCOC1CCN(C(=O)c1cnccn1)C2

$$$$
SWF000923
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    6.1295    3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    0.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    0.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    0.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615   -0.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  1  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
M  END
>  <HTSID>
SWF000923

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)c3cccc(C)n3)C[C@H]2N1C(C)C

$$$$
SWF000924
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    5.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    5.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000924

>  <SMILES>
CN(Cc1ccco1)[C@@H]1CN(S(=O)(=O)C2CC2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF000925
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000925

>  <SMILES>
O=C(c1cocn1)N1C[C@@H]2CN(Cc3ccco3)CCO[C@@H]2C1

$$$$
SWF000926
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.5442   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0524   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000926

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(OC)CO3)cc1

$$$$
SWF000927
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF000927

>  <SMILES>
c1cc(CN2C[C@@H]3OCCN(CCN4CCCC4)[C@@H]3C2)ccn1

$$$$
SWF000928
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000928

>  <SMILES>
Fc1ccccc1OC[C@@H]1CO[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF000929
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 21 23  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000929

>  <SMILES>
CS(=O)(=O)NCCC1CCOC12CN(C(=O)c1cccnc1)C2

$$$$
SWF000930
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.9770   -4.0454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6779   -4.7954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3789   -4.0454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6779   -6.2954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0086   -4.6555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3789   -7.0454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9770   -7.0454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0049   -3.5408   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3789   -8.5454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9770   -8.5454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000930

>  <SMILES>
O=C(c1cnccn1)N1CC[C@H]2[C@H]1CCN2Cc1cccnc1

$$$$
SWF000931
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.3147   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7215    1.8092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3202    1.0002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000931

>  <SMILES>
C1COC(CN2CCO[C@H]3CN(CC4CCOCC4)C[C@H]32)C1

$$$$
SWF000932
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    6.3862    0.1631   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7744    1.6120   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3255    1.2238   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7865   -1.2227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4474    1.3532   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9135   -3.4272   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5907   -2.7098   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2737   -1.0269   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6635   -7.3243   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 11 18  2  0  0  0  0
 11 19  1  0  0  0  0
 13 20  2  0  0  0  0
 16 21  1  0  0  0  0
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 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 12 15  1  0  0  0  0
 14 20  1  0  0  0  0
 22 24  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF000932

>  <SMILES>
CNC(=O)CN1CC2(CCN(Cc3cccs3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF000933
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.6747   -4.3761   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9535   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0567   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000933

>  <SMILES>
CC(C)NC(=O)C1CN(Cc2cccs2)CC12CCOCC2

$$$$
SWF000934
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703    1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740    2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0875   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3834   -4.7831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000934

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3ccccn3)CC[C@H]21)N1CCCO1

$$$$
SWF000935
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   14.4190   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  1  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000935

>  <SMILES>
CCCS(=O)(=O)N1C[C@@H](OCc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF000936
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4553   -1.0311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.7419   -5.7971   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3400   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6390   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF000936

>  <SMILES>
O=C(c1ccnnc1)N1CC[C@@H]2CN(Cc3ccccc3)S(=O)(=O)[C@@H]2CC1

$$$$
SWF000937
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000937

>  <SMILES>
CS(=O)(=O)NCC[C@@]12CCO[C@@H]1CCN(C(=O)c1ccco1)C2

$$$$
SWF000938
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  7  8  1  0  0  0  0
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  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF000938

>  <SMILES>
CNC(=O)c1cnc2n1CCN(C(=O)Cc1ccc(F)cc1)C2

$$$$
SWF000939
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.8484   -4.8829   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 13 10  1  6  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000939

>  <SMILES>
CN(Cc1ccco1)C[C@H]1OC[C@@H]2CCN(C(=O)c3ccncc3)C[C@@H]21

$$$$
SWF000940
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000940

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1cnc(C)cn1)CC2

$$$$
SWF000941
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  4  1  0  0  0  0
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  8 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000941

>  <SMILES>
CS(=O)(=O)NCC[C@@]12CCO[C@@H]1CCN(C1CCOCC1)C2

$$$$
SWF000942
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.5782    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.9090    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1000    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 14 15  1  1  0  0  0
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 16 17  2  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000942

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(Cc3ccsc3)C[C@H]2O1)N1CCCCO1

$$$$
SWF000943
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    6.4952    3.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    4.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 19 20  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF000943

>  <SMILES>
CCOCC12CCCOC1CCN(S(=O)(=O)N(C)C)C2

$$$$
SWF000944
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  1  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000944

>  <SMILES>
O=C(N[C@H]1CCO[C@]2(CCN(c3ncccn3)C2)C1)c1ccncc1

$$$$
SWF000945
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9049    2.5314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000945

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(C1CCCC1)C2)c1ccsc1

$$$$
SWF000946
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  1  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000946

>  <SMILES>
Fc1ccc(CN2CCO[C@H]3[C@H](Oc4ccccn4)CC[C@@H]32)cc1

$$$$
SWF000947
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7978   -4.0818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -4.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -4.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000947

>  <SMILES>
O=C1C[C@@H]2[C@H](CCN2CC2CCOCC2)N1c1cccnc1

$$$$
SWF000948
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9684   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4639   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8322   -5.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3240   -5.5808   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9341   -6.9511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF000948

>  <SMILES>
COCC1CC2(CCN(C(=O)/C=C/c3cccs3)CC2)CN1C

$$$$
SWF000949
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.8336    2.2223   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3701    0.7957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9028    0.4838   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3738   -0.3190   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4393   -0.9427   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8991    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9102   -1.7456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8410   -0.0071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4319    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9139   -2.8603   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.8447   -1.1219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3811   -2.5484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8658   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 13 10  1  6  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000949

>  <SMILES>
Cc1nnc(C[C@@H]2OC[C@H]3CN(C(=O)c4cccnc4)CC[C@H]32)o1

$$$$
SWF000950
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    2.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000950

>  <SMILES>
O=C(c1cnccn1)N1C[C@@H]2COC[C@]2(COCc2ccccn2)C1

$$$$
SWF000951
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4291    0.6401   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
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  5 10  1  0  0  0  0
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  9 15  1  1  0  0  0
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 10 17  1  0  0  0  0
 16 18  1  6  0  0  0
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 20 21  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 13  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000951

>  <SMILES>
Cc1ccoc1C(=O)N1CCO[C@@H]2[C@@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF000952
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000952

>  <SMILES>
Cn1cc(CN2CC[C@H]3OCC[C@@]3(C(=O)N3CCCC3)C2)cn1

$$$$
SWF000953
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1715    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000953

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1CN(CC2CC2)C[C@H]2OCC[C@H]21

$$$$
SWF000954
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   14.2262    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3446    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 14 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 14  1  0  0  0  0
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 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000954

>  <SMILES>
CCN(CC)C(=O)CC1CC2(CCN(C(=O)c3cccn3C)CC2)c2ccccc21

$$$$
SWF000955
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000955

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ncccn2)[C@@H]2CN(Cc3ccco3)C[C@H]12

$$$$
SWF000956
Actelion Java MolfileCreator 1.0

 20 23  0  0  0  0  0  0  0  0999 V2000
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   -4.8897   -3.7868   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF000956

>  <SMILES>
c1csc(CN2CC3(CCN(Cc4ccsc4)C3)C2)n1

$$$$
SWF000957
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   11.8479    5.1731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3479    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5979    6.4721   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1061    3.7172   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2080    2.5037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000957

>  <SMILES>
O=C(NC1CC1)[C@@H]1C[C@@H]2CCN(CCOCc3ccccc3)C[C@H]2O1

$$$$
SWF000958
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  6 11  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000958

>  <SMILES>
O=C(c1ccoc1)N1C[C@@H](Oc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF000959
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  6  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF000959

>  <SMILES>
CNC(=O)CC1CC2(CCN(S(=O)(=O)C3CC3)CC2)c2ccccc21

$$$$
SWF000960
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  4  7  1  0  0  0  0
  9 12  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000960

>  <SMILES>
Cc1ccc(CN2CC[C@H]3C[C@@H](c4ccnc(C)n4)O[C@@H]3C2)cc1

$$$$
SWF000961
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 30 31  1  0  0  0  0
 10 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000961

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(C(=O)c4ccoc4)CC3)c3ccccc32)CC1

$$$$
SWF000962
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   14.4272   -1.9978   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.9272   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8907   -3.4243   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4637   -3.4243   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6772   -4.3060   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0371   -3.8879   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000962

>  <SMILES>
Cc1ncsc1CN1CCC2(CCC(COCC3CC3)N2C)CC1

$$$$
SWF000963
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.5314   -5.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 13 10  1  1  0  0  0
 14 11  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 12  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000963

>  <SMILES>
O=C(C[C@H]1C[C@H]2CN(CC3CCOCC3)C[C@H]2O1)N1CCCCO1

$$$$
SWF000964
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    4.3005    1.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4345    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005    1.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8005    2.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060    0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  8  6  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
  8  9  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF000964

>  <SMILES>
Cc1noc(C[C@@H]2COC[C@H]3CN(S(C)(=O)=O)C[C@@H]23)n1

$$$$
SWF000965
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.1040   -1.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0569   -0.7128   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8361   -1.1374   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9700    0.3626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406   -2.1319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7496   -0.7307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.9504   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1610    0.9504   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9187   -2.3398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4187   -1.4738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4700    1.9014   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7301    0.6414   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4700    1.9014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  7 14  1  0  0  0  0
  8 15  2  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 12  1  0  0  0  0
 11 16  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000965

>  <SMILES>
Cc1occc1C(=O)N1C2CCC1CN(Cc1cccnc1)C2

$$$$
SWF000966
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.4864    2.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8986    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4374    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4864    0.6397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8986    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4374    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3986    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4041    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF000966

>  <SMILES>
COCC(=O)NC[C@]12COC[C@H]1CN(Cc1nccs1)C2

$$$$
SWF000967
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000967

>  <SMILES>
O=C(c1ccoc1)N1C[C@@H]2COC[C@]2(COCc2ccncc2)C1

$$$$
SWF000968
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  1  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000968

>  <SMILES>
O=C(NCC[C@@]12CCO[C@@H]1CCN(Cc1ccoc1)C2)N1CCCC1

$$$$
SWF000969
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1665    3.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000969

>  <SMILES>
O=C([C@@H]1C[C@@H]2CCN(CCN3CCCC3)C[C@H]2O1)N1CCCC1

$$$$
SWF000970
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 12  2  0  0  0  0
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M  END
>  <HTSID>
SWF000970

>  <SMILES>
O=C(c1ccco1)N1C[C@@H]2COC[C@]2(COCc2ccccn2)C1

$$$$
SWF000971
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1665    3.1808   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000971

>  <SMILES>
c1ccc(COC[C@]23COC[C@H]2CN(C2CCOCC2)C3)nc1

$$$$
SWF000972
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF000972

>  <SMILES>
Cn1cc(CN2CCO[C@@H]3CN(Cc4ccccc4F)C[C@@H]3C2)cn1

$$$$
SWF000973
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    8.8235    1.0873   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.9280    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
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 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000973

>  <SMILES>
O=C(c1cscn1)N1CCC[C@]2(C[C@H](OCc3cccnc3)CO2)C1

$$$$
SWF000974
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000974

>  <SMILES>
Cc1ccccc1CCC(=O)N1CC[C@@]2(C[C@@H](N(C)C)CCO2)C1

$$$$
SWF000975
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000975

>  <SMILES>
O=C1CCCN1Cc1ncn2c1CN(Cc1ccco1)CCC2

$$$$
SWF000976
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000976

>  <SMILES>
Cc1cccc(CN2CC3(CCN(C(=O)c4ccoc4)C3)C2)n1

$$$$
SWF000977
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF000977

>  <SMILES>
O=C(c1cccnc1)N1C[C@@H]2COC[C@]2(COc2ncccc2F)C1

$$$$
SWF000978
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    9.1665    1.4487   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
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  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF000978

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccc(F)cc1)C2)c1ccco1

$$$$
SWF000979
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6804   -4.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6859   -4.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -3.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2791   -5.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071   -2.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8669   -6.0704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891   -2.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4602   -6.9840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  1  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 21  1  0  0  0  0
 20 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000979

>  <SMILES>
CN(C)[C@H]1CCO[C@]2(CCN(C(=O)c3ccc4ccccc4c3)C2)C1

$$$$
SWF000980
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.0815   -8.0216   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  6  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  7  9  1  0  0  0  0
 13 12  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000980

>  <SMILES>
Fc1cccnc1O[C@H]1CO[C@@]2(CCCN(Cc3ccoc3)C2)C1

$$$$
SWF000981
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7160   -1.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.5349   -2.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5295   -3.0088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000981

>  <SMILES>
c1ccc(O[C@H]2CO[C@@]3(CCCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF000982
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072    3.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  6  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12  9  1  1  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF000982

>  <SMILES>
Cc1nnc([C@H]2C[C@@H]3CCN(C(=O)CCc4ccccc4)C[C@H]3O2)[nH]1

$$$$
SWF000983
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF000983

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccsc1)C2)c1cscn1

$$$$
SWF000984
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  9 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000984

>  <SMILES>
COCC(=O)N1CCC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF000985
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000985

>  <SMILES>
COc1ccc(C(=O)N2CCOC3CCC2C3OC)cc1F

$$$$
SWF000986
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF000986

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cc(C)no2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF000987
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF000987

>  <SMILES>
Cn1cc(CN2CCCC3(CC(OCC4CC4)CO3)C2)cn1

$$$$
SWF000988
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF000988

>  <SMILES>
O=C(c1cccnc1)N1C[C@H]2[C@@H](C1)c1ccccc1[C@@H]2N1CCOCC1

$$$$
SWF000989
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000989

>  <SMILES>
C[C@H]1CN(C(=O)C2CCOC2)C[C@@]12CCN(c1cccnc1)C2=O

$$$$
SWF000990
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 28 30  2  0  0  0  0
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 25 26  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF000990

>  <SMILES>
Cn1cnc2c(-c3ccccc3)nc(C3CCN(C(=O)c4ccccn4)CC3)cc21

$$$$
SWF000991
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF000991

>  <SMILES>
Cc1oncc1C(=O)N1CCOC2CCC1C2OCC1CC1

$$$$
SWF000992
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000992

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cnccn2)C[C@@H]1Cc1ccccc1

$$$$
SWF000993
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF000993

>  <SMILES>
COCC(=O)N1CCC2(COCc3cnc(NCc4ccco4)nc32)C1

$$$$
SWF000994
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000994

>  <SMILES>
c1csc(CN2CCC3(COCCN(Cc4ccoc4)C3)C2)c1

$$$$
SWF000995
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF000995

>  <SMILES>
O=C(NCC1CC1)C1COC2(CCN(Cc3cccnc3)CC2)C1

$$$$
SWF000996
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000996

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3O[C@@H](c4noc(C)n4)C[C@H]3C2)o1

$$$$
SWF000997
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF000997

>  <SMILES>
Cc1nnc(C[C@@H]2CO[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]23)o1

$$$$
SWF000998
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF000998

>  <SMILES>
O=C(c1ccccc1)N1CC[C@]2(C[C@@H](Oc3ccccn3)CO2)C1

$$$$
SWF000999
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF000999

>  <SMILES>
COCCN1[C@H]2CCNCC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF001000
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001000

>  <SMILES>
c1cncc(O[C@H]2CN(Cc3cccs3)[C@@H]3CCCO[C@H]23)c1

$$$$
SWF001001
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.9606   -4.2926   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001001

>  <SMILES>
Cc1ccnc(OC[C@@]23CCO[C@@H]2CCN(Cc2ccsc2)C3)n1

$$$$
SWF001002
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001002

>  <SMILES>
c1csc(CN2CCc3ncc(CN4CCOCC4)n3CC2)n1

$$$$
SWF001003
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 23 25  2  0  0  0  0
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M  END
>  <HTSID>
SWF001003

>  <SMILES>
C[C@H]1CN(C(=O)c2cnccn2)C[C@@]12CCN(c1cccnc1)C2=O

$$$$
SWF001004
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
 11  6  1  6  0  0  0
  9 12  1  0  0  0  0
 13  9  1  1  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 11 13  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001004

>  <SMILES>
CC(C)C(=O)N1C[C@@H]2CN(CC(=O)O)C[C@H]2c2ccccc21

$$$$
SWF001005
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0929   -3.3205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2739   -5.0430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  9  8  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001005

>  <SMILES>
O=C(c1cscn1)N1C[C@@H](Oc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF001006
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1665    3.1808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001006

>  <SMILES>
O=C(Cc1ccccc1)N1C[C@@H]2COC[C@]2(COCc2cccnc2)C1

$$$$
SWF001007
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1715    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 19 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001007

>  <SMILES>
O=C(NCc1cccnc1)[C@@H]1CN(CC2CC2)C[C@H]2OCC[C@H]21

$$$$
SWF001008
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4291    0.6401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001008

>  <SMILES>
O=C(c1ccoc1)N1CCO[C@H]2[C@@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF001009
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 20  2  0  0  0  0
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 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001009

>  <SMILES>
Cn1cc(CN2CCO[C@H]3[C@@H](Oc4cccnc4)CC[C@@H]32)cn1

$$$$
SWF001010
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    6.5907   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3508    0.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12  8  1  1  0  0  0
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 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001010

>  <SMILES>
c1coc(CN2CC[C@H]3C[C@@H](c4nnc(C5CC5)o4)O[C@@H]3C2)c1

$$$$
SWF001011
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.7221   -5.1517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -6.4508   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -7.7498   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001011

>  <SMILES>
O=C([C@H]1COC[C@H]2CN(Cc3ccoc3)C[C@H]21)N1CCCCO1

$$$$
SWF001012
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001012

>  <SMILES>
O=C(NCC1CC1)[C@@H]1C[C@@H]2CCN(c3ncccn3)C[C@H]2O1

$$$$
SWF001013
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  7  1  6  0  0  0
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 23 24  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001013

>  <SMILES>
Cc1noc(C[C@H]2CO[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]23)n1

$$$$
SWF001014
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001014

>  <SMILES>
CS(=O)(=O)NC[C@]12COC[C@H]1CN(C(=O)c1ccccc1)C2

$$$$
SWF001015
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0303   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
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 15 17  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001015

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)c3ccnn3C)CC2)N1C

$$$$
SWF001016
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.9699   -3.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  1  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001016

>  <SMILES>
CN(C)C(=O)CO[C@@H]1CC[C@H]2[C@H]1OCCN2Cc1ccoc1

$$$$
SWF001017
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6530   -2.3227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6748   -2.5306   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3221   -3.0658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001017

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2[C@@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF001018
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    8.2196    3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    3.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2196    2.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    2.1255   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001018

>  <SMILES>
O=C(NC1CC1)[C@@H]1C[C@@H]2CCN(Cc3ccsc3)C[C@H]2O1

$$$$
SWF001019
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    7.8655   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  6  3  1  6  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001019

>  <SMILES>
COc1ncccc1CN1C[C@H](c2nc(C)no2)C[C@H]2OCC[C@H]21

$$$$
SWF001020
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413   -1.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001020

>  <SMILES>
c1cnc(N[C@@H]2CCO[C@]3(CCN(C4CCCC4)C3)C2)nc1

$$$$
SWF001021
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.8147   -3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8147   -2.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8147   -4.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -3.4345   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001021

>  <SMILES>
CS(=O)(=O)N[C@@H]1COC[C@@H]2CN(Cc3cccnc3)C[C@@H]21

$$$$
SWF001022
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1905   -2.7980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2716   -4.4832   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6327   -4.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2919   -5.5828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7877   -5.4707   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5377   -6.7698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0377   -6.7698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7877   -8.0688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7877   -5.4707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2877   -8.0688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2877   -5.4707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0377   -6.7698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 11 12  1  0  0  0  0
 18 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001022

>  <SMILES>
CC(C)CNc1nc2c(cc1C(=O)N(C)C)CCN(Cc1ccccc1)CC2

$$$$
SWF001023
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.6513   -2.6970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -4.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9763   -4.7847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5943   -4.7847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2853   -5.7358   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853   -5.7358   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8731   -6.5448   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001023

>  <SMILES>
Cn1cc(CN2CC[C@H]3[C@H]2CCN3C(=O)c2cnn(C)c2)cn1

$$$$
SWF001024
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3119    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1147   -1.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9872   -2.9672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4138   -0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8037    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5046   -3.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4544   -2.6554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5236   -4.3938   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5537    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4581   -3.7701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5273   -5.5085   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9946   -5.1967   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9983   -6.3114   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5347   -7.7380   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5384   -8.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0675   -8.0498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0749  -10.2793   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6040   -9.4764   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6077  -10.5911   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  6  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001024

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4cccnc4)CC3)CC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF001025
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -3.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1800   -2.9418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6435   -1.5152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1837   -4.0565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1108   -1.2034   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6509   -3.7447   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1145   -2.3181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001025

>  <SMILES>
O=C([C@H]1CC[C@@H]2[C@@H](CCN2C2CCCCC2)O1)N1CCOCC1

$$$$
SWF001026
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    0.2299    1.7572   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3345    2.7517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1254    0.7626   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7646    1.8617   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8936    2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8071    1.9890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6766    1.4476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8676    2.0354   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  8  9  1  0  0  0  0
 12 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001026

>  <SMILES>
COC[C@@H]1CN(CC2CC2)C[C@@]12CCN(S(C)(=O)=O)C2

$$$$
SWF001027
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    4.2709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    5.1369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    6.0029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    7.0029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    6.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  7  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001027

>  <SMILES>
CN(Cc1ccccn1)C(=O)[C@@H]1C[C@@H]2CCN(CC3CC3)C[C@H]2O1

$$$$
SWF001028
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8367    2.4790   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2652    4.0061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8404    3.5937   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4848    5.3051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7324    4.3179   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2107    2.9836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5189    6.4198   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9766    5.4619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8892    5.8097   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1883    6.5597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001028

>  <SMILES>
CCN1C[C@@H](COC)[C@]2(CCN(C(=O)c3cc(C)oc3C)C2)C1

$$$$
SWF001029
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2902    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2902    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2413    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2413    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001029

>  <SMILES>
Cc1nc(COC[C@]23COC[C@H]2CN(C(=O)c2ccoc2)C3)cs1

$$$$
SWF001030
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    4.6215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    5.8815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001030

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@H](OCc4cccnc4)CC[C@@H]32)no1

$$$$
SWF001031
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    4.6215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    5.8815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001031

>  <SMILES>
Cc1cc(CN2CCO[C@@H]3[C@@H](OCc4ccncc4)CC[C@@H]32)no1

$$$$
SWF001032
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2556   -3.1887   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7226   -3.3966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9247   -3.9319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6157   -4.8829   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9029   -3.7240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6460   -4.3931   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3096   -2.8104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5120   -3.8931   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5415   -5.3876   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3041   -2.9149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001032

>  <SMILES>
Cc1occc1C(=O)N1CC[C@H]2CO[C@H](CNS(C)(=O)=O)[C@H]2C1

$$$$
SWF001033
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -4.1970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5649   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7558   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2340   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7728   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7340   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001033

>  <SMILES>
Cn1cccc1C(=O)N1CC[C@@H]2[C@@H]1CC(=O)N2Cc1cccnc1

$$$$
SWF001034
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4834    4.7537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852    5.9672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0935    6.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
 13  9  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 16 17  2  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001034

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccccc2)C1

$$$$
SWF001035
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.0413   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -3.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -4.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -3.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7725   -5.3385   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3548   -4.6341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -5.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  1  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001035

>  <SMILES>
O=C1NC2(CCN(Cc3cccnc3)CC2)CC1c1cccnc1

$$$$
SWF001036
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703    1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568    3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740    2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240    4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8469   -3.3565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0875   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3834   -4.7831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0838   -5.0950   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5474   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5437   -7.6363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0072   -9.0628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9235   -7.3244   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0035  -10.1776   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9272   -8.4391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4637   -9.8657   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001036

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3ccncc3)CC[C@H]21)N1CCCO1

$$$$
SWF001037
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001037

>  <SMILES>
Cn1cc(CN2CC[C@@]3(C[C@@H](NC(=O)N4CCCC4)CCO3)C2)cn1

$$$$
SWF001038
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.8955    4.0476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3132    4.7521   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3187    4.6476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7309    5.4566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9119    3.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7363    5.3520   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9174    3.6295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3296    4.4385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001038

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(C(=O)Nc3ccccc3)CC2)O1

$$$$
SWF001039
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6845    2.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4935    1.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0154    1.6636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5154    0.7976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 12  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001039

>  <SMILES>
CCOCC12CCCOC1CCN(C(=O)CC1C=CCC1)C2

$$$$
SWF001040
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    3.7172   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    3.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    2.5037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3152    2.1918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517    0.7652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 13  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001040

>  <SMILES>
CCn1nnc2c1C(COC)CN(C(=O)Cc1ccccn1)C2

$$$$
SWF001041
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7226   -3.3966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001041

>  <SMILES>
COc1ccc(CN2CC[C@@H]3[C@@H](CO[C@@H]3CC(=O)NC3CC3)C2)cc1

$$$$
SWF001042
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8005    2.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3005    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005    1.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3005    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060    0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8883    1.1397   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8883    2.7577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8394    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  1  0  0  0
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 11 12  2  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001042

>  <SMILES>
O=C(c1ccco1)N1C[C@H]2CCCN(Cc3ccccn3)[C@H]2C1

$$$$
SWF001043
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
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 13 11  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001043

>  <SMILES>
O=C(NC[C@@H]1CCC[C@]2(CCN(c3ncccn3)C2)O1)c1ccsc1

$$$$
SWF001044
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001044

>  <SMILES>
COCC1CC2(CCN(C3CCC3)CC2)CN1Cc1ccncc1

$$$$
SWF001045
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001045

>  <SMILES>
CN(C)C(=O)NC[C@]12COC[C@H]1CN(Cc1ccccn1)C2

$$$$
SWF001046
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  6  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001046

>  <SMILES>
O=C(c1ccnnc1)N1CCO[C@H]2[C@@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF001047
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 23 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001047

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccccn3)CC2)Oc2ccccc21)NC1CC1

$$$$
SWF001048
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3955   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1872   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0532   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9193   -2.6970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1872   -4.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9193   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1872   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0532   -6.1970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001048

>  <SMILES>
Cc1nc(CN2C(=O)C[C@@H]3[C@@H]2CCN3C(=O)c2ccncc2)cs1

$$$$
SWF001049
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6275    7.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8185    6.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8451    6.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001049

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(Cc3cnn(C)c3)CC2)CO1

$$$$
SWF001050
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0490   13.5044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7990   14.8035   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0490   16.1025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010   14.8035   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490   16.1025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001050

>  <SMILES>
O=C(c1ccnnc1)N1CCC(c2nc3ccc(Nc4ccccc4)cn3n2)CC1

$$$$
SWF001051
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135    1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045    2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827    1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8364   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -4.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -5.7283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -5.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001051

>  <SMILES>
O=C(C[C@@H]1COC[C@H]2CN(Cc3ccco3)C[C@@H]12)N1CCCC1

$$$$
SWF001052
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.9073    0.2319   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8028   -0.7626   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0119    1.2264   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9018    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7218    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7655    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0745    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  8 10  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001052

>  <SMILES>
CS(=O)(=O)N1C[C@@H](OCCCn2cccn2)[C@H]2OCCC[C@H]21

$$$$
SWF001053
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001053

>  <SMILES>
Cc1cnc2n1CCN(C)C21CCN(Cc2nccs2)CC1

$$$$
SWF001054
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5506   -1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7596   -3.0823   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7415   -1.6810   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4640   -0.6991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
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  6 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 21 24  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001054

>  <SMILES>
O=C(NCCc1ccccn1)[C@@]12CCO[C@@H]1CCN(C1CCC1)C2

$$$$
SWF001055
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   14.2894   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001055

>  <SMILES>
CC(C)N(C)CC1CCC2(CCN(c3ncccn3)CC2)CO1

$$$$
SWF001056
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001056

>  <SMILES>
Cc1cc(CN2CC[C@@]3(C[C@H](Nc4ccccn4)CCO3)C2)no1

$$$$
SWF001057
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.7498    2.1731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7498    3.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4508    2.9230   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9998    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9998    3.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  7  1  6  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001057

>  <SMILES>
CCS(=O)(=O)N1C[C@@H]2COC[C@]2(COCc2cccnc2)C1

$$$$
SWF001058
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8660    9.8690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 27 30  2  0  0  0  0
 29 31  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001058

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCN(C(=O)c5ccnnc5)CC4)nn3c2)c1

$$$$
SWF001059
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3850   -2.3227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6941   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9812   -0.2127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9594   -0.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3121    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001059

>  <SMILES>
C=CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)Cc1ccccc1

$$$$
SWF001060
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7347    2.6853   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3643    3.2954   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4775    2.9112   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001060

>  <SMILES>
COCC1CCS(=O)(=O)C12CN(C(=O)c1ccc(C)cn1)C2

$$$$
SWF001061
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1376    6.3701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
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  7 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001061

>  <SMILES>
c1ccc(COC2COC3(CCN(Cc4cccnc4)CC3)C2)cc1

$$$$
SWF001062
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    5.4179   -4.3479   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6089   -4.9356   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2269   -3.7601   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0057   -5.1569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8301   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5211   -2.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  6  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF001062

>  <SMILES>
CN(C)C(=O)N[C@H]1CCO[C@]2(CCN(S(C)(=O)=O)C2)C1

$$$$
SWF001063
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4814   -5.2368   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5505   -4.8715   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6304   -6.2257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7686   -5.4950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8486   -6.8492   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -6.4838   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
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 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001063

>  <SMILES>
Cn1cc(CN2CCO[C@@H]3CN(C(=O)c4ccncn4)C[C@@H]3C2)cn1

$$$$
SWF001064
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.9073   -0.2319   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -1.2264   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8028    0.7626   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128   -0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2437    0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  6  8  1  0  0  0  0
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  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001064

>  <SMILES>
CS(=O)(=O)N1CC[C@@]2(C[C@@H](NC(=O)c3cccnc3)CCO2)C1

$$$$
SWF001065
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 16 19  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001065

>  <SMILES>
O=C(Cc1ccccn1)N1C[C@@H]2CN(Cc3ccco3)CCO[C@@H]2C1

$$$$
SWF001066
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  6  0  0  0
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 13 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001066

>  <SMILES>
c1csc(CN2CC[C@@]3(C[C@H](N4CCCC4)CCO3)C2)c1

$$$$
SWF001067
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   12.8238   -1.6480   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6103   -3.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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 16 18  1  6  0  0  0
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 18 20  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001067

>  <SMILES>
COCC1CC2(CCN(Cc3ccco3)CC2)CN1Cc1ccccn1

$$$$
SWF001068
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001068

>  <SMILES>
O=C(NCC1CC1)C1CCC2(CCN(C(=O)c3ccco3)CC2)O1

$$$$
SWF001069
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001069

>  <SMILES>
c1cncc(CN2CC[C@H]3CO[C@H](CN4CCOCC4)[C@H]3C2)c1

$$$$
SWF001070
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8147    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.2050    1.9296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001070

>  <SMILES>
O=C(N[C@@H]1CCO[C@]2(CCN(Cc3ccccc3)C2)C1)N1CCCC1

$$$$
SWF001071
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0725    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0772   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4949   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001071

>  <SMILES>
COCC1CC2(CCN(CC3CC3)CC2)CN1Cc1cccnc1

$$$$
SWF001072
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.7543    2.2577   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001072

>  <SMILES>
c1coc(CN2C[C@H]3CCC[C@@]3(COCc3ccncc3)C2)c1

$$$$
SWF001073
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001073

>  <SMILES>
O=C(N1CCCC1)N1CCOCC2(CCN(c3ccccn3)C2)C1

$$$$
SWF001074
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    2.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3301    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001074

>  <SMILES>
CS(=O)(=O)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF001075
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1544    1.1576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001075

>  <SMILES>
O=C(C1CC1)N1CCC[C@]2(C[C@H](OCc3ccncc3)CO2)C1

$$$$
SWF001076
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7054    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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  8 12  2  0  0  0  0
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  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001076

>  <SMILES>
O=C(c1ccoc1)N1C[C@H]2CCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF001077
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.6721   -1.2275   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4354   -3.6546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 20 19  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001077

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CCN(CC3CCOC3)CC2)C1

$$$$
SWF001078
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001078

>  <SMILES>
O=C([C@@H]1CCCO1)N1CCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF001079
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3029   -4.2248   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001079

>  <SMILES>
O=C1CC[C@H]2[C@H](CCN2Cc2nccs2)N1Cc1ccncc1

$$$$
SWF001080
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001080

>  <SMILES>
O=C(C1Cn2ccnc2C2(CCN(Cc3ccncc3)CC2)O1)N1CCCC1

$$$$
SWF001081
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    7.5303   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 15  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001081

>  <SMILES>
Cc1ccccc1C(=O)N1CCCC2(CC(C(=O)NCc3cccnc3)=NO2)C1

$$$$
SWF001082
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   11.8888   -1.7881   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5838   -1.0346   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4262    0.4641   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5461    1.4725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001082

>  <SMILES>
CC(C)CN1CC2(CCN(C(=O)CCc3ccccc3)CC2)C2(CCN(C)C2=O)C1

$$$$
SWF001083
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    6.4408   -2.1748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0537   -0.7981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3575    1.5631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0808   -1.0275   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9476    2.0970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6610    3.0312   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001083

>  <SMILES>
CCN1CCC2(CN(CC(C)C)CC23CCN(C(=O)c2cccc(C)c2)CC3)C1=O

$$$$
SWF001084
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2004   -2.0363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001084

>  <SMILES>
COCCN1CCC2(CCCN(Cc3cccnc3)C2)C1=O

$$$$
SWF001085
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
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  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001085

>  <SMILES>
CC(=O)N1CC(C(=O)O)CN2CCN(C(=O)Cc3ccccc3)CC2C1

$$$$
SWF001086
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    7.5303   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001086

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CC(C(=O)NCc4cccnc4)=NO3)C2)cc1

$$$$
SWF001087
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  8 10  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001087

>  <SMILES>
COCC1CC2(CCN(Cc3ccoc3)CC2)CN1S(C)(=O)=O

$$$$
SWF001088
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 14 17  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001088

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccoc2)[C@@H]2CN(Cc3cccnc3)C[C@@H]21

$$$$
SWF001089
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001089

>  <SMILES>
COCC1CCC2(CCN(c3ncccn3)CC2)N1S(C)(=O)=O

$$$$
SWF001090
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001090

>  <SMILES>
CN(C)C(=O)NC[C@H]1CCC[C@]2(CCN(C3CCCC3)C2)O1

$$$$
SWF001091
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  1  0  0  0
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 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001091

>  <SMILES>
O=S(=O)(NC[C@]12COC[C@H]1CN(Cc1ccco1)C2)C1CC1

$$$$
SWF001092
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001092

>  <SMILES>
Cn1cc(CN2CC3(CCN(Cc4ccsc4)C3)C2)cn1

$$$$
SWF001093
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
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  8 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001093

>  <SMILES>
COCC(=O)N1CCO[C@]2(CCC[C@H]2COc2cccnc2)C1

$$$$
SWF001094
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.3147   -4.3005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001094

>  <SMILES>
CO[C@H]1CCN(C(=O)N2CCCC2)[C@@H]2CN(Cc3ccco3)C[C@H]12

$$$$
SWF001095
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5914   -6.0611   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1847   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  1  0  0  0
 10 12  1  0  0  0  0
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 21 22  2  0  0  0  0
  6  8  1  0  0  0  0
 13 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001095

>  <SMILES>
C=CCO[C@H]1CN(C(=O)c2cccc(F)c2)[C@@H]2CCCO[C@H]12

$$$$
SWF001096
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  1  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001096

>  <SMILES>
c1ccc(CO[C@@H]2CC[C@H]3[C@H]2OCCN3c2ncccn2)nc1

$$$$
SWF001097
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -5.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001097

>  <SMILES>
O=C(c1cccnc1)N1CCc2c(COCc3ccncc3)cncc2C1

$$$$
SWF001098
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001098

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(Cc3ccncc3)C2)O1

$$$$
SWF001099
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001099

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)CC(COCC2CC2)N(C)C3)c1

$$$$
SWF001100
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001100

>  <SMILES>
COc1cc(N2C[C@@H]3COC[C@]3(C(=O)N3CCCO3)C2)ncn1

$$$$
SWF001101
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001101

>  <SMILES>
c1csc(CN2CCC3(CCN(Cc4ccncc4)CC3)C2)c1

$$$$
SWF001102
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 16  2  0  0  0  0
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 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001102

>  <SMILES>
O=C(c1ccnnc1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF001103
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 18 20  1  0  0  0  0
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  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001103

>  <SMILES>
Cc1ccc(CN2CC3(CCN(Cc4ccsc4)C3)C2)o1

$$$$
SWF001104
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.5492   -1.0986   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001104

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cccs3)CC2)CN1C(C)C

$$$$
SWF001105
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  1  0  0  0
 13 14  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001105

>  <SMILES>
CS(=O)(=O)N1CCO[C@@H]2CN(C(=O)Cc3ccco3)C[C@@H]2C1

$$$$
SWF001106
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001106

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(CC2CC2)CC3)cc1

$$$$
SWF001107
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
   15.6192   -2.2056   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.8692   -3.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3692   -3.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6192   -4.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3692   -3.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692   -6.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692   -3.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 14 16  2  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
  6  8  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001107

>  <SMILES>
O=C(C1CCOCC1)N1CCC(c2nc3ccc(-c4cccc(F)c4)cn3n2)CC1

$$$$
SWF001108
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.3923   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001108

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CCN(Cc3ccco3)CC2)CC1

$$$$
SWF001109
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1349    7.0704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1294    6.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001109

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CC1)CCN(c1ncccn1)C2

$$$$
SWF001110
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001110

>  <SMILES>
Cc1nnc(C[C@@H]2C[C@H]3CN(C(=O)c4ccc(C)s4)C[C@H]3O2)o1

$$$$
SWF001111
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.9825    0.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 11 13  1  6  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001111

>  <SMILES>
O=C(C[C@@H]1CO[C@@H]2CN(Cc3ccc4c(c3)OCO4)C[C@H]12)NC1CC1

$$$$
SWF001112
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3692   -3.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3692   -8.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001112

>  <SMILES>
O=S(=O)(C1CC1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)CC1

$$$$
SWF001113
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   12.5768   -4.0767   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001113

>  <SMILES>
CN(Cc1ccncc1)C1COC2(CCN(CC3CCOCC3)CC2)C1

$$$$
SWF001114
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001114

>  <SMILES>
COCC(=O)N1C[C@H]2CCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF001115
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.5793   -2.0773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  1  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001115

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1ccc3c(c1)OCO3)CC2

$$$$
SWF001116
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001116

>  <SMILES>
COCC(=O)NC[C@]12COC[C@H]1CN(Cc1cnn(C)c1)C2

$$$$
SWF001117
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 14 10  1  1  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001117

>  <SMILES>
Cc1nnc([C@H]2C[C@@H]3CCN(C(=O)c4ccccn4)C[C@H]3O2)[nH]1

$$$$
SWF001118
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001118

>  <SMILES>
CS(=O)(=O)NCc1nnc2n1CCN(C(=O)c1cccnc1)C2

$$$$
SWF001119
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.5042    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001119

>  <SMILES>
CS(=O)(=O)N1CCOCC12CCN(Cc1ccco1)CC2

$$$$
SWF001120
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001120

>  <SMILES>
c1cnc(NC2COC3(CCN(Cc4ccoc4)C3)C2)cn1

$$$$
SWF001121
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 12 17  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001121

>  <SMILES>
c1ccc(COC[C@@]23CCC[C@@H]2CN(Cc2ccccn2)C3)nc1

$$$$
SWF001122
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    4.0805    4.1895   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3896    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8018    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2085    1.5159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1867    1.3080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001122

>  <SMILES>
c1coc(CN2CC[C@]3(C2)CN(CC2CC2)C[C@@H]3COCC2CC2)c1

$$$$
SWF001123
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001123

>  <SMILES>
Cc1ccc(CN2CC3(CCN(C(=O)c4cscn4)C3)C2)o1

$$$$
SWF001124
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.7865   -2.7227   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2354   -3.1109   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001124

>  <SMILES>
CN1CC2(CCN(Cc3cccnc3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF001125
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001125

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1C[C@@H]2CCN(Cc3ccco3)C[C@@H]2O1

$$$$
SWF001126
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.3767   -2.8983   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6965   -3.6313   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001126

>  <SMILES>
CC(=O)N1CCOCC2(CN(Cc3cccnc3)CCO2)C1

$$$$
SWF001127
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4560   -4.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001127

>  <SMILES>
CCN1CCOCC2(CCCN(C(=O)c3ccnnc3)C2)C1

$$$$
SWF001128
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.6770   -1.2661   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634   -1.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3461   -2.0092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8680   -2.6673   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8461   -2.8752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 12  9  1  6  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001128

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)c4ccccn4)C3)CC2=O)s1

$$$$
SWF001129
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13 11  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001129

>  <SMILES>
Cn1cc(CN2C[C@@H](C(=O)N3CCCO3)C[C@H]3OCC[C@H]32)cn1

$$$$
SWF001130
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6402   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2803    1.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.1879    3.1699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3062    4.3835   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001130

>  <SMILES>
Cc1noc(C)c1CN1CCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF001131
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1224    1.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113    0.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903   -1.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001131

>  <SMILES>
c1cnc(N2CCOCC3(CCCN(Cc4ccoc4)C3)C2)nc1

$$$$
SWF001132
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001132

>  <SMILES>
c1cncc(OC2COC3(CCN(Cc4ccco4)CC3)C2)c1

$$$$
SWF001133
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.9031   -2.7634   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7691   -2.2634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001133

>  <SMILES>
CN(C)C(=O)COC[C@@]12CCO[C@@H]1CCN(Cc1cccs1)C2

$$$$
SWF001134
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.0502    2.6065   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5137    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9810    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9847    3.2302   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 16 20  1  0  0  0  0
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 20 24  2  0  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
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 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001134

>  <SMILES>
COc1cc(N2CCO[C@H]3[C@@H](OCc4ccncc4)CC[C@@H]32)ncn1

$$$$
SWF001135
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
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 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001135

>  <SMILES>
COC[C@H]1CNC(=O)[C@@H]2CCN(Cc3cnn(C)c3)CC[C@H]12

$$$$
SWF001136
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  6  0  0  0
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 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001136

>  <SMILES>
O=C(C1=CCCC1)N1CCO[C@H]2[C@@H](Oc3ncccc3F)CC[C@@H]21

$$$$
SWF001137
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.3747    3.2749   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3692    3.1704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7111    1.6923   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5771    2.1923   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0383    3.9136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001137

>  <SMILES>
Cc1nnc(N2CCO[C@H]3[C@H](OCc4ccccn4)CC[C@@H]32)s1

$$$$
SWF001138
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3492   -3.3565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2837   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4518   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2800   -5.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   13.8758    3.3267   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001138

>  <SMILES>
OCCOC1CC2(CCN(Cc3ccncc3)CC2)c2ccccc21

$$$$
SWF001139
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2837   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2800   -5.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6556    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1474    0.7429   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7739    1.7996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7575    2.1132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3840    3.1699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001139

>  <SMILES>
OCCOC1CC2(CCN(Cc3ccccn3)CC2)c2ccccc21

$$$$
SWF001140
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001140

>  <SMILES>
c1cnc(N2C[C@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)nc1

$$$$
SWF001141
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.0673    4.7989   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6853    4.7989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7040    1.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  6  0  0  0
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 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001141

>  <SMILES>
CN(C)C(=O)N1CCCC2(CCN(c3ccsc3)C2=O)C1

$$$$
SWF001142
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.6153    1.1257   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8335    0.5022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001142

>  <SMILES>
CC(C)CN1C[C@@H]2CN(C(=O)c3ccccc3)CCO[C@@H]2C1

$$$$
SWF001143
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001143

>  <SMILES>
Cc1nnc(C[C@@H]2C[C@H]3CN(C(=O)c4cc(C5CC5)on4)C[C@H]3O2)o1

$$$$
SWF001144
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 18 22  2  0  0  0  0
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 19 24  1  0  0  0  0
  6  9  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001144

>  <SMILES>
Cc1cccc(CO[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2ccoc2)n1

$$$$
SWF001145
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF001145

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@@H](C(=O)NC4CC4)O[C@@H]3C2)nn1

$$$$
SWF001146
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 13 16  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001146

>  <SMILES>
Cc1ccc(CN2CC[C@H]3OCC[C@@]3(CCNC(=O)N(C)C)C2)o1

$$$$
SWF001147
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.7027    3.6442   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001147

>  <SMILES>
CN1C[C@@H](COCC2CC2)[C@]2(CCN(S(=O)(=O)C3CC3)C2)C1

$$$$
SWF001148
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.6316   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF001148

>  <SMILES>
CN(C)CCOCC1CCC2C1OCCN2Cc1ccco1

$$$$
SWF001149
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001149

>  <SMILES>
O=C(c1ccncc1F)N1CC[C@H]2[C@H]1CCN2c1ncccn1

$$$$
SWF001150
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7978   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001150

>  <SMILES>
Cc1noc(C[C@@H]2CO[C@@H]3CN(C(=O)c4ccc(C)o4)C[C@H]23)n1

$$$$
SWF001151
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6520    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 16 14  1  1  0  0  0
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 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
 15 16  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001151

>  <SMILES>
O=C(NCCc1cccs1)[C@@H]1C[C@H]2OCC[C@H]2N(C2CCCC2)C1

$$$$
SWF001152
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001152

>  <SMILES>
CN(C)C(=O)NCC1CC12CCN(C(=O)c1ccco1)CC2

$$$$
SWF001153
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
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 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001153

>  <SMILES>
c1cc(CO[C@@H]2CN(Cc3ccoc3)[C@@H]3CCCO[C@@H]32)ccn1

$$$$
SWF001154
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2778    3.3267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 21 23  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001154

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CC1)CCN(CC1CC1)C2=O

$$$$
SWF001155
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001155

>  <SMILES>
O=C(NC[C@@H]1OC[C@@H]2CN(Cc3cccnc3)CC[C@@H]21)C1CC1

$$$$
SWF001156
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1224    1.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113    0.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  2  0  0  0  0
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 11 13  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001156

>  <SMILES>
c1cnc(N2CCOCC3(CCCN(Cc4ccoc4)C3)C2)cn1

$$$$
SWF001157
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 16  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001157

>  <SMILES>
CCN1CCOCC2(CCCN(C(=O)c3ccoc3C)C2)C1

$$$$
SWF001158
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.6747   -4.3761   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001158

>  <SMILES>
CC(C)NC(=O)C1CN(Cc2nccs2)CC12CCOCC2

$$$$
SWF001159
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3291   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8209   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001159

>  <SMILES>
O=C(c1ccccn1)N1CCC2(CCN(Cc3cccnc3)C2)CC1

$$$$
SWF001160
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3132    4.7521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2086    5.7466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3996    5.1588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001160

>  <SMILES>
CN(Cc1ccncc1)C1COC2(CCN(CC3CC3)CC2)C1

$$$$
SWF001161
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    6.9154    1.3345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6018   -0.1406   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2241   -0.7540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6110   -1.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3818   -2.2539   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9738    0.0613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8569   -2.5674   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9475   -1.7878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6953   -3.7290   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9181    1.5081   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8268   -2.7969   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6121    2.2621   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3925   -2.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1997    0.1533   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6121    3.7702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0790   -0.8558   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2718   -3.3400   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1625   -2.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2832   -3.8831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7175   -3.4171   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  5  7  1  0  0  0  0
 13 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001161

>  <SMILES>
CC[C@@H]1N(C(=O)c2cccc(C)n2)CCC[C@]12CCC(=O)N2CCOC

$$$$
SWF001162
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001162

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(Cc1ccc(F)cc1)CC2

$$$$
SWF001163
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5897   -1.4575   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9033    1.5260   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.2383   -0.1226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001163

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)CC(OCc1ccncc1)CO2

$$$$
SWF001164
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
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  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001164

>  <SMILES>
CN(Cc1cccnc1)C1COC2(CCN(CC3CC3)CC2)C1

$$$$
SWF001165
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001165

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)NCCn2c(-c4ccccc4)cnc23)o1

$$$$
SWF001166
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001166

>  <SMILES>
O=C(N[C@H]1CCO[C@]2(CCN(Cc3ccccc3)C2)C1)N1CCCC1

$$$$
SWF001167
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
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  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001167

>  <SMILES>
Cn1nnc2c1CCN(C(=O)c1ccoc1)C2COCC1CC1

$$$$
SWF001168
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   12.8238   -1.6480   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001168

>  <SMILES>
COCC1CC2(CCN(Cc3nccs3)CC2)CN1C(C)C

$$$$
SWF001169
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
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 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001169

>  <SMILES>
Cc1ccc(N2CC[C@H]3OCC[C@@H](C(=O)N4CCCC4)[C@H]3C2)nn1

$$$$
SWF001170
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  3  1  1  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001170

>  <SMILES>
CCO[C@H]1CC[C@H]2[C@H]1OCCN2C(=O)COc1ccccc1

$$$$
SWF001171
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    4.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2218    5.3479   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0873    6.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2218    5.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7218    6.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5308    6.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001171

>  <SMILES>
O=C(c1ccno1)N1CCC2(CC1)CC(N1CCCC1)=NO2

$$$$
SWF001172
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    7.7942   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1192   -3.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7372   -3.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4282   -4.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4282   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733    1.6691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 20  1  0  0  0  0
 21 22  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001172

>  <SMILES>
O=C(Nc1ccccc1)C1Cn2ccnc2C2(CCN(C(=O)c3ccno3)CC2)O1

$$$$
SWF001173
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0692    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7261    5.1254   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2093    4.9018   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2428    5.3489   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9496    6.6086   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001173

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@@H]2CN(S(C)(=O)=O)CCO[C@@H]2C1

$$$$
SWF001174
Actelion Java MolfileCreator 1.0

 27 29  0  0  1  0  0  0  0  0999 V2000
    3.7406    5.1731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    3.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3805    2.5037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4824    3.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2406    7.7711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7406    7.7711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4906    3.8740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9906    3.8740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 14 20  2  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  8  9  1  0  0  0  0
 15 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001174

>  <SMILES>
COc1cccc(CC(=O)N2C[C@H]3CCCC(OCC(=O)N(C)C)[C@H]3C2)c1

$$$$
SWF001175
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001175

>  <SMILES>
Cn1cc(CN2C[C@H](C(=O)N3CCCC3)[C@@H]3CCO[C@@H]3C2)cn1

$$$$
SWF001176
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6530   -2.3227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3469   -0.2502   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6833   -1.8329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8469    0.6158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5493   -1.3329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001176

>  <SMILES>
Cn1cccc1C(=O)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF001177
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3850   -2.3227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6941   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9812   -0.2127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9594   -0.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3121    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2684    0.9463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6211    1.4815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5993    1.6894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  1  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  6  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001177

>  <SMILES>
C=CCO[C@H]1CC[C@H]2[C@@H]1OCCN2C(=O)Cc1ccccc1

$$$$
SWF001178
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2278   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -4.0537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5413   -4.6235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0142   -2.5216   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9967   -4.5565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001178

>  <SMILES>
CNC(=O)[C@@]12CCO[C@@H]1CCN(Cc1cccnc1OC)C2

$$$$
SWF001179
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    6.4027    3.4009   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4613    3.7382   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8500    2.9771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3243    2.1264   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8627    1.2837   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001179

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(C(=O)c3ccsc3)C[C@H]1CN(c1ccccn1)C2

$$$$
SWF001180
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.7534   -1.9186   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8489   -3.6858   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001180

>  <SMILES>
CC(=O)N1CCOCC2(CN(Cc3ccc(F)cc3)CCO2)C1

$$$$
SWF001181
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001181

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(C(=O)c1ccccn1)CC2

$$$$
SWF001182
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    0.0855    6.8817   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 20 21  1  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001182

>  <SMILES>
CNC(=O)[C@@H]1CCO[C@@H]2CCN(Cc3scnc3C)C[C@@H]21

$$$$
SWF001183
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001183

>  <SMILES>
Cc1cccc(COC[C@]23COC[C@H]2CN(C2CCC2)C3)n1

$$$$
SWF001184
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001184

>  <SMILES>
CC(=O)N1CCOCC2(CN(Cc3ccsc3)CCO2)C1

$$$$
SWF001185
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    0.5158    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF001185

>  <SMILES>
CN(C)C(=O)[C@@]12CCCN(c3ncccn3)[C@@H]1CN(C(=O)Nc1ccccc1)C2

$$$$
SWF001186
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001186

>  <SMILES>
CO[C@@H]1CCN(C2CCC2)[C@@H]2CN(Cc3cccnc3)C[C@@H]21

$$$$
SWF001187
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1794   -2.7295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7931   -1.0565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7742   -1.2498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 11 14  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001187

>  <SMILES>
CC(C)C(=O)N1CCN(C(=O)c2cccnc2)CC2(CC(=O)N(C)C2)C1

$$$$
SWF001188
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8813    2.4562   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8277    2.1329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963    3.4560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2903   -1.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001188

>  <SMILES>
c1coc(CN2CCCC3(COCCN(c4nncs4)C3)C2)c1

$$$$
SWF001189
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001189

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4cnn(C)c4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF001190
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3610    1.8478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001190

>  <SMILES>
CCS(=O)(=O)N1CCC2(CC1)NC(=O)CC2c1cnn(C)c1

$$$$
SWF001191
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   11.6058   -4.6317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1423   -6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1788   -4.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6423   -6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  6  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001191

>  <SMILES>
CNC(=O)C1Cn2ccnc2C2(CCN(Cc3cccs3)CC2)O1

$$$$
SWF001192
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.3596   -6.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3814   -6.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8814   -5.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001192

>  <SMILES>
CCN(CC)C(=O)C1Cn2ccnc2C2(CCN(Cc3cccs3)CC2)O1

$$$$
SWF001193
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001193

>  <SMILES>
Cn1cc(CN2CCCC3(CCN(S(=O)(=O)C4CC4)C3)C2)cn1

$$$$
SWF001194
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.9023    1.5020   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001194

>  <SMILES>
CS(=O)(=O)N1CCCCC12CCCN(Cc1ccncc1)C2

$$$$
SWF001195
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   12.0423    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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M  END
>  <HTSID>
SWF001195

>  <SMILES>
COCCNC(=O)C[C@@H]1C[C@H]2CN(Cc3ccsc3)C[C@H]2O1

$$$$
SWF001196
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001196

>  <SMILES>
CN(C)CC(=O)N1CC[C@]2(C[C@@H](OCC3CCOCC3)CO2)C1

$$$$
SWF001197
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001197

>  <SMILES>
Cc1ccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N3CCCC3)C2)o1

$$$$
SWF001198
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0475   -2.5933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -3.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7167   -3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2167   -4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6234   -5.1160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0356   -5.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4423   -6.8385   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5467   -6.6295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1400   -7.5430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001198

>  <SMILES>
CN(C)C(=O)N1CCCC2(CC(Nc3ncccn3)CO2)C1

$$$$
SWF001199
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    7.8045   -4.1266   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1865   -4.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2354   -3.8176   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF001199

>  <SMILES>
Cc1ccsc1CN1C[C@@H]2C[C@H](CC(=O)N(C)C)O[C@@H]2C1

$$$$
SWF001200
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   -1.2589    3.0019   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5898    3.7451   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9280    2.2588   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5157    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0020    3.6710   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7236    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4353    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0195    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1785    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9706    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7796   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4487    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6178    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9875   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4268    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5314    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  6  0  0  0
 13 17  2  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001200

>  <SMILES>
CN1C(=O)[C@H]2CN(c3ncccn3)C[C@H]2C12CCN(S(C)(=O)=O)CC2

$$$$
SWF001201
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.9826    4.6317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097    4.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462    6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1061   -2.2172   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5979   -2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2080   -1.0037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6752   -0.6918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001201

>  <SMILES>
C=CCOCC1c2nnn(C)c2CCN1Cc1cccs1

$$$$
SWF001202
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2280    4.6215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    5.8815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001202

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@H](OCc4ccncc4)CC[C@@H]32)no1

$$$$
SWF001203
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413   -1.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7104    0.4750   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5194   -0.9262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6240    0.0683   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001203

>  <SMILES>
c1ccc(N[C@H]2CCO[C@]3(CCN(C4CCCC4)C3)C2)nc1

$$$$
SWF001204
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8206   -1.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1078   -2.5168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3132    4.7521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6222    5.7031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3132    4.7521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8132    6.2909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0042    5.7031   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0531    6.0122   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001204

>  <SMILES>
CCOC1CC2(CCN(Cc3cnn(C)c3)CC2)c2ccc(C)cc21

$$$$
SWF001205
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.4305   -1.0582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001205

>  <SMILES>
Cc1noc(C[C@]23COC[C@H]2CN(Cc2ccsc2)C3)n1

$$$$
SWF001206
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    3.8374    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3855    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9022    1.2677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2708   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4860   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2060    0.8256   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0027   -2.4694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0688   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3021   -1.9670   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2226   -7.6977   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 12 19  1  0  0  0  0
 14 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  1  0  0  0
 15 20  1  0  0  0  0
 21 22  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001206

>  <SMILES>
CCN1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(Cc3cccnc3)[C@H]2CC1

$$$$
SWF001207
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001207

>  <SMILES>
O=C(C1CC=CC1)N1CCC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF001208
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9841    0.1157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2557   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7475   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3576   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6292   -3.5249   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1292   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1656   -4.9515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0108   -2.3113   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3792   -5.8331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001208

>  <SMILES>
O=C1CCCN1[C@H]1CCO[C@]2(CCN(Cc3ccc(Cl)cc3)C2)C1

$$$$
SWF001209
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2869    3.2807   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7869    1.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0959    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7869    1.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  7  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001209

>  <SMILES>
CCN1CC2(CCN(Cc3ccco3)CC2)C(COC)C1=O

$$$$
SWF001210
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8364   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -4.8147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8364   -3.9487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8364   -5.6808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3364   -4.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8364   -5.6808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001210

>  <SMILES>
O=C([C@H]1COC[C@H]2CN(c3ncccn3)C[C@H]21)N1CCOCC1

$$$$
SWF001211
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9544   -4.9927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5724   -4.9927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2634   -5.9437   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -5.9437   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001211

>  <SMILES>
O=C(c1cnoc1)N1CC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF001212
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6679    2.4352   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6679   -0.9352   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1303    2.1015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1303   -0.6015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7812    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2812    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0312   -0.5490   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0312    2.0490   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5312   -0.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5312    2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2812    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001212

>  <SMILES>
CNC(=O)c1cc2c(nc1NC(C)C)CCN(c1ncccn1)CC2

$$$$
SWF001213
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9544   -4.9927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5724   -4.9927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2634   -5.9437   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -5.9437   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001213

>  <SMILES>
O=C(N1CCCC1)N1CC[C@]2(C[C@@H](Oc3ccccn3)CO2)C1

$$$$
SWF001214
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001214

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@]2(C[C@@H](OCc3cccnc3)CO2)C1

$$$$
SWF001215
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703    1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568    3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740    2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240    4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8469   -3.3565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0875   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3834   -4.7831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0838   -5.0950   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5474   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5437   -7.6363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0072   -9.0628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9235   -7.3244   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0035  -10.1776   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9272   -8.4391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001215

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(Cc3cccnc3)CC[C@H]21)N1CCCO1

$$$$
SWF001216
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6811    3.9801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2210    3.3620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6858    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1721    3.0530   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6369    1.4057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3800    2.0749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3311    1.7658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  1  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001216

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)c1ccc(C)nc1)CC2

$$$$
SWF001217
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.8484   -6.2702   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4362   -5.4611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8539   -6.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0295   -4.5476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001217

>  <SMILES>
c1ccc(OC2COC3(CCN(C4CCOCC4)CC3)C2)nc1

$$$$
SWF001218
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -4.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295   -4.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -5.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295   -5.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -6.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001218

>  <SMILES>
O=C(c1ncccn1)N1CC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF001219
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -0.3272   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -0.8272   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2275    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001219

>  <SMILES>
O=C(c1ccncn1)N1CC[C@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF001220
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001220

>  <SMILES>
c1ccc(CN2CC[C@]3(C[C@H](Oc4ccccn4)CO3)C2)nc1

$$$$
SWF001221
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 15 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001221

>  <SMILES>
Cc1cc(CN2C[C@@H]3COC[C@]3(CNC(=O)C3CC3)C2)no1

$$$$
SWF001222
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.2192   -3.0722   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4271   -2.0941   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7329   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001222

>  <SMILES>
Cc1ccc(OC[C@H]2CO[C@@H]3CN(C4CCOCC4)C[C@H]23)cn1

$$$$
SWF001223
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2135   -1.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 24 25  1  0  0  0  0
 13 16  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001223

>  <SMILES>
Cc1ccc(CN2CC[C@H]3OCC[C@@]3(CCNC(=O)C(C)C)C2)cc1

$$$$
SWF001224
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
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 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001224

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@@H]2CCN(CC3CC3)C[C@H]2O1

$$$$
SWF001225
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.1674   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4546   -3.3966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1237   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6941    0.3896   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160    1.0477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001225

>  <SMILES>
c1cncc(O[C@H]2CN(Cc3ccco3)[C@@H]3CCCO[C@H]23)c1

$$$$
SWF001226
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.9898    2.1535   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7576    0.9364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3563    1.9544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
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  4  8  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001226

>  <SMILES>
c1cncc(O[C@H]2CN(CCN3CCCC3)[C@@H]3CCCO[C@H]23)c1

$$$$
SWF001227
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6891    4.1215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  5  9  1  1  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001227

>  <SMILES>
c1cncc(CO[C@H]2CC[C@H]3[C@@H]2OCCN3Cc2ccco2)c1

$$$$
SWF001228
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.9596    2.6728   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.0936    2.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2275    2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0936    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615    2.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2275    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5819    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3910   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
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 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001228

>  <SMILES>
CN(C)C(=O)CO[C@H]1CO[C@@]2(CCN(c3ncc(F)cn3)C2)C1

$$$$
SWF001229
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2033   -5.1335   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001229

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cccc(C)c3)CC2)CO1

$$$$
SWF001230
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4328   -7.7872   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6463   -5.6853   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9000   -8.0991   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6500   -6.8001   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1418   -6.6433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001230

>  <SMILES>
Cc1cccc(S(=O)(=O)N2CCC3(CC2)CCn2c(-c4cnn(C)c4)cnc23)c1

$$$$
SWF001231
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.5856   -0.1151   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5637   -0.3230   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6074    0.0928   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    0.8630   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001231

>  <SMILES>
CS(=O)(=O)N1CCCC12CCN(Cc1ccncc1)CC2

$$$$
SWF001232
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1833    5.9672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001232

>  <SMILES>
COCCNC(=O)[C@@H]1CC[C@@H]2[C@@H](CCN2Cc2ccccn2)O1

$$$$
SWF001233
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 13 19  2  0  0  0  0
 14 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 17 23  1  0  0  0  0
 17 24  2  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 18 24  1  0  0  0  0
 19 22  1  0  0  0  0
 21 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001233

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(CC4CC4)CC3)O2)c1

$$$$
SWF001234
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4836    0.6855   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7405    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6426    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9484    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8994    2.6418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3642    4.2891   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5721    5.2672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  1  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001234

>  <SMILES>
C=CCOC[C@@H]1CCC[C@@]12CN(Cc1cccnc1)CCO2

$$$$
SWF001235
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5263   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001235

>  <SMILES>
COc1cccc(CN2CCC3(CCN(Cc4ccncc4)CC3)CC2)c1

$$$$
SWF001236
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4639   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  6  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001236

>  <SMILES>
O=C1NC2(CCN(C(=O)Cc3cccs3)CC2)CC1c1ccccc1

$$$$
SWF001237
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -2.4839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6126   -1.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2527   -3.2370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9016   -2.6182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0681   -1.4192   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  1  0  0  0  0
 25 28  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF001237

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(Cc3ccco3)C[C@H]1CN(Cc1cnn(C)c1)C2

$$$$
SWF001238
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.4790   -3.6137   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8332   -2.5338   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001238

>  <SMILES>
CC(=O)N1CC(C(=O)O)CN2CCN(Cc3cccc(C)n3)CC2C1

$$$$
SWF001239
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    8.5442   -4.5583   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5807   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  6  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001239

>  <SMILES>
COCC1CN(C(=O)c2ccsc2)Cc2ncn(CC3CC3)c21

$$$$
SWF001240
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001240

>  <SMILES>
O=C(Cc1cccc(F)c1)N1CC[C@H](O)[C@@H]1Cc1ccccc1

$$$$
SWF001241
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 17  1  0  0  0  0
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 16 19  1  1  0  0  0
 17 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  8  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001241

>  <SMILES>
COc1cccc(CC(=O)N2C[C@@H]3C[C@@H](c4nnc(C)[nH]4)O[C@@H]3C2)c1

$$$$
SWF001242
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.1674   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1237   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
  6  8  1  0  0  0  0
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 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001242

>  <SMILES>
c1cncc(O[C@@H]2CN(Cc3ccoc3)[C@@H]3CCCO[C@@H]32)c1

$$$$
SWF001243
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001243

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2[C@@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF001244
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001244

>  <SMILES>
Cn1cncc1CN1CCC2(CC(=O)N(c3ccccc3)C2)C1

$$$$
SWF001245
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  3  0  0  0  0
  5  7  1  0  0  0  0
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 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001245

>  <SMILES>
N#Cc1cccc(NC2COC3(CCN(Cc4ccncc4)C3)C2)n1

$$$$
SWF001246
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001246

>  <SMILES>
CN(C)C(=O)N1C[C@H](OCc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF001247
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 23 25  2  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001247

>  <SMILES>
O=C(C1CCOCC1)N1C[C@@H](OCc2cccnc2)[C@H]2OCCC[C@@H]21

$$$$
SWF001248
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  6  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001248

>  <SMILES>
COC1COC2(CCN(C(=O)CCc3ccccc3C)CC2)C1

$$$$
SWF001249
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9603    1.4297   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4603    0.5636   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001249

>  <SMILES>
Cn1cc(-c2cnc3n2CCC32CCN(S(C)(=O)=O)CC2)cn1

$$$$
SWF001250
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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 22 24  2  0  0  0  0
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 11 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001250

>  <SMILES>
c1csc(CN2CCCC3(COCCN(c4cncnc4)C3)C2)c1

$$$$
SWF001251
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 10 14  1  1  0  0  0
 12 15  1  0  0  0  0
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 20 22  2  0  0  0  0
  8 10  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001251

>  <SMILES>
C=CCC(=O)N1C[C@@H](OCc2ccncc2)[C@H]2OCCC[C@H]21

$$$$
SWF001252
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001252

>  <SMILES>
O=C(NC1CCC1)[C@H]1C[C@@H]2CCN(CCOCc3ccccc3)C[C@H]2O1

$$$$
SWF001253
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001253

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)c3cc(C)ccn3)CC2)N1C

$$$$
SWF001254
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
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 17 20  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001254

>  <SMILES>
O=C(C1Cn2ccnc2C2(CCN(Cc3ccoc3)CC2)O1)N1CCCC1

$$$$
SWF001255
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
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  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001255

>  <SMILES>
O=C(c1ccco1)N1CCC2OCCCC2(COCC2CCC2)C1

$$$$
SWF001256
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001256

>  <SMILES>
O=C(c1ccco1)N1C[C@@H]2COC[C@]2(COCC2CCC2)C1

$$$$
SWF001257
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6766    1.4476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8676    2.0354   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6321    4.2891   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0621    4.6492   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  8  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001257

>  <SMILES>
COCC1C(=O)N(CC2CC2)CC12CCN(C(=O)N(C)C)CC2

$$$$
SWF001258
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0671   -3.0544   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8861   -1.3318   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0616   -2.9499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8806   -1.2273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4684   -2.0363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4629   -1.9318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001258

>  <SMILES>
Cc1cnc(N[C@@H]2CCO[C@]3(CCN(CC4CC4)C3)C2)nc1

$$$$
SWF001259
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3658   -4.0095   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2639   -5.2230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6777   -5.4767   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3786   -6.2267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2218   -7.7185   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001259

>  <SMILES>
Cc1cc(CN2CC[C@H]3C[C@@H](C(=O)N4CCOCC4)O[C@@H]3C2)no1

$$$$
SWF001260
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0303   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3091   -2.2829   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1181   -2.8707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9271   -2.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2059   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001260

>  <SMILES>
Cc1ccoc1C(=O)N1CCC2(CCC(COCC3CC3)N2C)CC1

$$$$
SWF001261
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2556   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001261

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(Cc3ccoc3)CC[C@H]21)Nc1cccnc1

$$$$
SWF001262
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001262

>  <SMILES>
CN(C)c1cc(N[C@H]2CCO[C@]3(CCN(CC4CC4)C3)C2)ncn1

$$$$
SWF001263
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.2942   -5.5388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6032   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2942   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001263

>  <SMILES>
CN(C)C(=O)CC1CCC2(CC1)CCN(C(=O)c1ccsc1)CC2

$$$$
SWF001264
Actelion Java MolfileCreator 1.0

 21 22  0  0  1  0  0  0  0  0999 V2000
    7.0938    3.8477   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0448    3.5387   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7847    2.8966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 10  9  1  6  0  0  0
 12 13  1  0  0  0  0
M  END
>  <HTSID>
SWF001264

>  <SMILES>
COCCNC(=O)C[C@H]1OC[C@H]2CN(S(C)(=O)=O)CC[C@H]21

$$$$
SWF001265
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3955    4.9136   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001265

>  <SMILES>
COCC1CCC2(CCN(C(=O)c3ccc(C)s3)CC2)N1C

$$$$
SWF001266
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9378    4.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001266

>  <SMILES>
Cc1cccc(CN2CC[C@@]3(C[C@@H](N4CCCC4=O)CCO3)C2)c1

$$$$
SWF001267
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9378    4.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3081    3.4465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 23 24  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001267

>  <SMILES>
CCc1ccc(CN2CC[C@@]3(C[C@H](N4CCCC4=O)CCO3)C2)cc1

$$$$
SWF001268
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.0468   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0468   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001268

>  <SMILES>
CCOCC1C[C@@H]2OCCN(Cc3ccc4c(c3)OCO4)[C@H]2C1

$$$$
SWF001269
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001269

>  <SMILES>
CO[C@@H]1CCN(Cc2ccco2)[C@@H]2CN(Cc3ccncc3)C[C@@H]21

$$$$
SWF001270
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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 11 14  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001270

>  <SMILES>
O=C(NCC1OCCc2cn(CC3CCOCC3)nc21)c1ccccc1

$$$$
SWF001271
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
   13.0260    3.3370   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5588    3.0251   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5551    4.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6281    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0990    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0186    5.5664   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6355   -0.9427   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1682   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 12  1  0  0  0  0
 13 15  1  0  0  0  0
M  END
>  <HTSID>
SWF001271

>  <SMILES>
CN(C)CCNC(=O)c1noc2c1CN(C(=O)N(C)C)CC2

$$$$
SWF001272
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001272

>  <SMILES>
c1ccc(CO[C@H]2CO[C@@]3(CCN(c4ncccn4)C3)C2)nc1

$$$$
SWF001273
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001273

>  <SMILES>
CCOCC12CCCOC1CCN(Cc1c(C)noc1C)C2

$$$$
SWF001274
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.9998    3.4721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9998    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6099   -0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1315    0.9595   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1315    3.3866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5581    1.4231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5581    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814   -1.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001274

>  <SMILES>
Cn1cccc1C(=O)N1C[C@H]2CCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF001275
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001275

>  <SMILES>
CO[C@H]1CCN(Cc2ccco2)[C@@H]2CN(Cc3ccncc3)C[C@H]12

$$$$
SWF001276
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.1172    1.1997   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2218    0.2052   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0127    2.1943   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1118    1.3043   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  1  0  0  0
  9 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001276

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCO[C@]2(CCN(C(=O)c3ccoc3)C2)C1

$$$$
SWF001277
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.7054    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001277

>  <SMILES>
c1ccc(COC[C@]23COC[C@H]2CN(Cc2ccoc2)C3)nc1

$$$$
SWF001278
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001278

>  <SMILES>
Cn1cc(C(=O)N2CCO[C@@H]3CN(Cc4ccco4)C[C@@H]3C2)cn1

$$$$
SWF001279
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001279

>  <SMILES>
CC(C)C(=O)NC[C@@H]1CCC[C@]2(CCN(c3ncccn3)C2)O1

$$$$
SWF001280
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001280

>  <SMILES>
O=C(N1CCCO1)[C@]12COC[C@H]1CN(CC1CCOCC1)C2

$$$$
SWF001281
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -1.2135    6.1317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500    7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2135    6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7500    7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001281

>  <SMILES>
COCC1COCCC12CCN(C(=O)c1cccs1)CC2

$$$$
SWF001282
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  6  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001282

>  <SMILES>
O=C(c1ncccn1)N1CC[C@]2(C[C@H](Oc3cccnc3)CO2)C1

$$$$
SWF001283
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -4.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295   -4.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0314   -4.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -5.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295   -5.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  6  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 18  1  0  0  0  0
 17 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001283

>  <SMILES>
CO[C@@H]1CO[C@@]2(CCN(C(=O)c3cccc4c3OCCO4)C2)C1

$$$$
SWF001284
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001284

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)COC(COc1ccccn1)C2

$$$$
SWF001285
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5493   -1.3329   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3414   -0.3547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0105    0.3884   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001285

>  <SMILES>
Cc1cc(CN2CCO[C@H]3[C@H](Oc4cccnc4)CC[C@@H]32)no1

$$$$
SWF001286
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7310   -2.0367   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1982   -2.3486   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7383    0.1927   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7420    1.3075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2093    0.9956   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2785    2.7340   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2130    2.1103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2822    3.8488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7494    3.5369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7531    4.6516   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 17 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001286

>  <SMILES>
Cc1cnc(N2CCO[C@@H]3C(CNc4ncccn4)CC[C@H]32)nc1

$$$$
SWF001287
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -0.8660    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  6  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001287

>  <SMILES>
COCC1COCCC12CCN(C(=O)c1ccc(C)nc1)CC2

$$$$
SWF001288
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6891    4.1215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6946    4.2260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    4.6215   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  2  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 14 20  1  0  0  0  0
 16 21  1  1  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001288

>  <SMILES>
CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1cn(C)c2ccccc12

$$$$
SWF001289
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5196   -0.4706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001289

>  <SMILES>
CC(C)N1CC2CCCC(C1)C2CC(=O)NCc1ccco1

$$$$
SWF001290
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001290

>  <SMILES>
Cc1ccc(CN2C[C@@H]3[C@@H](C2)OCC(=O)N3Cc2ccncc2)s1

$$$$
SWF001291
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   10.3923    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001291

>  <SMILES>
O=C([C@H]1CN(c2ncc(F)cn2)C[C@H]2OCC[C@@H]12)N1CCCC1

$$$$
SWF001292
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.6678   -2.1220   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001292

>  <SMILES>
Cc1oncc1C(=O)N1CC2CC1(C(=O)NCc1ccco1)C2

$$$$
SWF001293
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.7500    8.6703   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001293

>  <SMILES>
COCC1COCCC12CCN(C(=O)C1CC(F)(F)C1)CC2

$$$$
SWF001294
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.3701    0.7957   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6819   -0.6715   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7966    0.3322   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9028    0.4838   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8336    2.2223   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3008    2.5342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF001294

>  <SMILES>
CC[C@@H]1OC[C@H]2CN(S(=O)(=O)c3cccc(OC)c3)CC[C@H]21

$$$$
SWF001295
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -0.0000    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 17  2  0  0  0  0
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 15 19  1  6  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001295

>  <SMILES>
COCC1COCCC12CCN(C(=O)Cc1ccccc1)CC2

$$$$
SWF001296
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4721   -3.8527   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4758   -4.9674   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8461   -4.3573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1452   -5.1073   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4442   -4.3573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7432   -5.1073   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4442   -2.8573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0423   -4.3573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.7432   -2.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0423   -2.8573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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 10  6  1  6  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001296

>  <SMILES>
O=S(=O)(C1CC1)N1CC[C@]2(C[C@@H](Oc3ncccc3F)CO2)C1

$$$$
SWF001297
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  1  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001297

>  <SMILES>
COCC1COCCC12CCN(Cc1ccccc1C)CC2

$$$$
SWF001298
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3850   -2.4544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8208   -1.1153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1907   -3.2721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6942   -1.6023   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1889   -3.3319   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8580   -2.5888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5681   -4.2572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5590   -4.3915   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0329   -5.2721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2501   -3.6687   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1511   -4.1025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF001298

>  <SMILES>
O=C1CCC2(CCCN(Cc3ccco3)CC2)N1Cc1cccc(F)c1

$$$$
SWF001299
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7024    3.1808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0388    4.7634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9049    4.2634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001299

>  <SMILES>
CS(=O)(=O)NC[C@]12COC[C@H]1CN(C(=O)CC1CCCC1)C2

$$$$
SWF001300
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   -0.0534   -8.8875   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9351   -7.6740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3250   -6.3037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4269   -7.8308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1422   -5.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0750   -5.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4306   -6.7160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1769   -9.1298   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0713   -3.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8009   -7.3261   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1187   -5.2488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6441   -8.8179   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001300

>  <SMILES>
CCN(CC)[C@H]1CCO[C@]2(CCN(C(=O)c3ccoc3C)C2)C1

$$$$
SWF001301
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.1240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.8740   -5.3527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
 10  8  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001301

>  <SMILES>
O=C(NCc1cccs1)[C@@H]1C[C@@H]2CCN(CC3CC3)C[C@H]2O1

$$$$
SWF001302
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.6750    1.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8940    1.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  9  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001302

>  <SMILES>
Cc1nnc([C@H]2C[C@H]3OCC[C@H]3N(C(=O)c3sccc3C)C2)o1

$$$$
SWF001303
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.8147   -3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8147   -2.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8147   -4.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -3.4345   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  3  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001303

>  <SMILES>
CS(=O)(=O)N[C@@H]1COC[C@@H]2CN(Cc3cccc(C#N)c3)C[C@@H]21

$$$$
SWF001304
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0671   -3.0544   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0616   -2.9499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4684   -2.0363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4629   -1.9318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001304

>  <SMILES>
Cc1cnc(N[C@@H]2CCO[C@]3(CCN(Cc4cccnc4)C3)C2)nc1

$$$$
SWF001305
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2463    2.5579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    3.1906   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0007    4.1215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6116    3.4887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9881    4.2706   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3423    5.3505   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1241    5.9740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2732    4.9851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 12  2  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001305

>  <SMILES>
O=C(c1ccco1)N1CCO[C@@H]2CN(CC3CC3)CC[C@@H]2C1

$$$$
SWF001306
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8258   -4.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0394   -6.7418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8221   -5.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5721   -7.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9620   -8.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001306

>  <SMILES>
Cc1noc([C@@H]2CCO[C@@H]3CCN(S(=O)(=O)CC(C)C)C[C@@H]32)n1

$$$$
SWF001307
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.0933    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8433   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3433    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1833   -4.4672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6915   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  1  1  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  1  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001307

>  <SMILES>
CS(=O)(=O)N1C[C@H]2OCC[C@H]2[C@H](C(=O)NCc2ccccn2)C1

$$$$
SWF001308
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3917    0.5649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1348    1.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0859    0.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8949    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3949   -0.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7039    0.9250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3949   -0.0261   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9827   -0.8351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001308

>  <SMILES>
Cn1cc(CN2C[C@@H]3[C@H](CNC(=O)c4cnccn4)CO[C@@H]3C2)cn1

$$$$
SWF001309
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5296   -1.3368   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7419   -1.5792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8293   -2.2909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8053   -2.5084   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1050   -3.4624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4817   -1.7719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0810   -3.6800   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4578   -1.9894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7574   -2.9434   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001309

>  <SMILES>
c1cncc(CN2CCOC3CCC2C3OCc2ccncc2)c1

$$$$
SWF001310
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    7.6722   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6941   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3850   -2.3227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4340   -2.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9728   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4340   -3.6317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3850   -3.9407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001310

>  <SMILES>
O=C(c1ccoc1)N1CCO[C@H]2[C@H](OCCN3CCCC3)CC[C@@H]21

$$$$
SWF001311
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0054    2.5172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4032    3.4347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7551    1.8554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 23 25  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001311

>  <SMILES>
O=C(CC1C=CCC1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF001312
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001312

>  <SMILES>
Cc1noc(C)c1CN1CCC2(CC(=O)N(c3ccccn3)C2)C1

$$$$
SWF001313
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5358    0.9115   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3548    2.6341   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5303    1.0160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001313

>  <SMILES>
O=C(c1ncccn1)N1CC[C@]2(CCC[C@H](CN3CCOCC3)O2)C1

$$$$
SWF001314
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001314

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)c4ccoc4C)C3)C2=O)n1

$$$$
SWF001315
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  1  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001315

>  <SMILES>
CC1c2nc(C(=O)N3CCCCC3)cn2CCN1CC1CCCC1

$$$$
SWF001316
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001316

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(c1ncccn1)C2)c1cscn1

$$$$
SWF001317
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1389    3.6515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8858    5.7649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7675    6.9785   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1574    8.3488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001317

>  <SMILES>
COCC(=O)N1CCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF001318
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001318

>  <SMILES>
CCc1cnc(N2CC[C@@H]3[C@@H](CO[C@@H]3CNC(=O)N(C)C)C2)nc1

$$$$
SWF001319
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 12 14  1  6  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001319

>  <SMILES>
Cc1cc(CN2C[C@@H]3[C@H](CC(=O)NCC4CC4)CO[C@@H]3C2)no1

$$$$
SWF001320
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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   -0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4487    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001320

>  <SMILES>
CN(Cc1ccco1)C1CCC12CCN(Cc1cccnc1)CC2

$$$$
SWF001321
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001321

>  <SMILES>
Cc1nc(COC[C@@]23CCC[C@@H]2CN(C(=O)N2CCCC2)C3)cs1

$$$$
SWF001322
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9773    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4337    3.1029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001322

>  <SMILES>
O=C(c1ccoc1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF001323
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
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 17 18  2  0  0  0  0
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 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001323

>  <SMILES>
Cc1cc(CN2CC[C@H]3C[C@@H](C(=O)NC4CC4)O[C@@H]3C2)no1

$$$$
SWF001324
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 17 19  2  0  0  0  0
 20 17  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001324

>  <SMILES>
O=C(c1ccncc1)N1CCc2ncnc(C3CCOC3)c2CC1

$$$$
SWF001325
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8322    2.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10 14  2  0  0  0  0
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 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001325

>  <SMILES>
CN1CC[C@]2(CCC[C@H](CNS(=O)(=O)c3ccccc3)O2)C1

$$$$
SWF001326
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   11.4667   -0.9168   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.4630    0.1980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9265    1.6245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9228    2.7393   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9920    1.0008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9847    3.2302   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001326

>  <SMILES>
Fc1ccc(CN2CCO[C@H]3[C@@H](OCc4ccccn4)CC[C@@H]32)cc1

$$$$
SWF001327
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8855   -1.1855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3503   -2.8328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -3.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3929   -3.5019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  2  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001327

>  <SMILES>
CCN1C(=O)[C@H]2CN(C(C)=O)C[C@H]2C12CCN(C(=O)c1ccncc1)CC2

$$$$
SWF001328
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001328

>  <SMILES>
CO[C@H]1CCN(Cc2nccs2)C[C@@H]1Cc1ccccc1

$$$$
SWF001329
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
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  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 11  1  0  0  0  0
 12 14  2  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001329

>  <SMILES>
CN1CCC(CO[C@H]2CN(C(=O)c3cccn3C)[C@@H]3COC[C@H]23)CC1

$$$$
SWF001330
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.2508    0.5450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001330

>  <SMILES>
Cn1cc(CN2CCCC3(CCN(Cc4ccncc4)C3)C2)cn1

$$$$
SWF001331
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001331

>  <SMILES>
CN(C)S(=O)(=O)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF001332
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001332

>  <SMILES>
CN(C)C(=O)COC[C@]12COC[C@H]1CN(c1ncccn1)C2

$$$$
SWF001333
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5296   -1.3368   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7419   -1.5792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
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 18 23  2  0  0  0  0
 18 24  1  0  0  0  0
 19 25  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 25  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001333

>  <SMILES>
Cc1noc(C)c1CN1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF001334
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4937    2.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3597    2.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6277    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9937    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9937    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5870    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9882    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5326   -1.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001334

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@]2(CC(=O)NCc2cccnc2)C1

$$$$
SWF001335
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0303   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3091   -2.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1181   -2.8707   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9271   -2.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5334    2.5051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001335

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)c3ccoc3)CC2)N1CC1CC1

$$$$
SWF001336
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.6184   -4.1523   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6221   -5.2670   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0856   -3.8404   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3066   -2.6851   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5037   -5.1560   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1235   -1.4271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0771   -4.6925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8692    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001336

>  <SMILES>
CN(C)S(=O)(=O)N1CC2(C1)OCCC2CCOCc1ccncc1

$$$$
SWF001337
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.3956    0.8368   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4068    0.6878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8762   -0.1011   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2722   -1.1091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4947   -4.7078   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001337

>  <SMILES>
C=CCOC1C2CCC1N(Cc1cccnc1OC)CCO2

$$$$
SWF001338
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.4347    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3974   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3974   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 15 13  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001338

>  <SMILES>
O=C(C[C@H]1C[C@H]2CN(Cc3ccccc3)C[C@H]2O1)NCc1cccs1

$$$$
SWF001339
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.0827   -5.4969   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9259   -4.0051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1394   -3.1235   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5556   -3.3950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826   -1.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5097   -3.7336   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2437   -1.9278   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2565   -4.1450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7233   -2.8519   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -1.7710   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8582   -3.1413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.3601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529    0.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -0.2454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202    1.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001339

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@H]2OCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF001340
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4814   -5.2368   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5505   -4.8715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6304   -6.2257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7686   -5.4950   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8486   -6.8492   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9177   -6.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001340

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3CN(Cc4ccoc4)CCO[C@@H]3C2)cn1

$$$$
SWF001341
Actelion Java MolfileCreator 1.0

 27 29  0  0  1  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1029    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0534   -1.0311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1530   -2.0513   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0409   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3400   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -3.5471   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.3400   -5.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -6.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -8.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9380   -5.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9380   -8.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2371   -6.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2371   -8.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001341

>  <SMILES>
CN(C)C(=O)CN1C[C@H]2CCN(C(=O)Nc3ccccc3)CC[C@H]2S1(=O)=O

$$$$
SWF001342
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    5.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    5.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001342

>  <SMILES>
c1cncc(CO[C@@H]2CO[C@@]3(CCN(Cc4ccncc4)C3)C2)c1

$$$$
SWF001343
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001343

>  <SMILES>
Cc1cc(C(=O)N2CC[C@@]3(C[C@H](N4CCCC4)CCO3)C2)cc(C)n1

$$$$
SWF001344
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
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  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001344

>  <SMILES>
Cc1cc(CN2CC[C@]3(C[C@H](Oc4ccccn4)CO3)C2)no1

$$$$
SWF001345
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001345

>  <SMILES>
CN(C)CC(=O)N1CC[C@]2(C[C@H](OCc3cccnc3)CO2)C1

$$$$
SWF001346
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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 11 14  2  0  0  0  0
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 16 20  1  0  0  0  0
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 23 24  1  0  0  0  0
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 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001346

>  <SMILES>
Cc1cnc(C(=O)N2CCC3(CCC(COCC4CC4)N3C)CC2)cn1

$$$$
SWF001347
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   14.4272   -1.9978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9272   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 19  1  6  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001347

>  <SMILES>
CCOCC1CCC2(CCN(Cc3ccc(C)o3)CC2)N1C

$$$$
SWF001348
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001348

>  <SMILES>
C=CCN1C(=O)CCCC12CCCN(S(=O)(=O)CC)C2

$$$$
SWF001349
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.8549    4.2283   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 21 23  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001349

>  <SMILES>
O=C(C[C@]12COC[C@H]1CN(Cc1cccs1)C2)N1CCCCO1

$$$$
SWF001350
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6402   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001350

>  <SMILES>
Cc1ncsc1CN1CC[C@]2(CCC[C@@H](CN3CCCC3)O2)C1

$$$$
SWF001351
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001351

>  <SMILES>
O=C(c1ccc[nH]1)N1CCC2(CC1)OCCNc1ccccc12

$$$$
SWF001352
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7414   -1.5928   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001352

>  <SMILES>
COCC1CCC2(CCN(Cc3cnn(C)c3)CC2)N1S(C)(=O)=O

$$$$
SWF001353
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001353

>  <SMILES>
CN(C)S(=O)(=O)N1CC[C@@]2(C[C@@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001354
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001354

>  <SMILES>
O=C1CCCN1[C@H]1CCO[C@]2(CCN(Cc3cccs3)C2)C1

$$$$
SWF001355
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001355

>  <SMILES>
O=C(c1cnccn1)N1CC[C@@]2(C[C@@H](N3CCCC3=O)CCO2)C1

$$$$
SWF001356
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF001356

>  <SMILES>
Cn1cc(CN2CC[C@@]3(C[C@@H](N4CCCC4=O)CCO3)C2)cn1

$$$$
SWF001357
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 13 11  1  1  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001357

>  <SMILES>
c1csc(CN2CC[C@H]3C[C@@H](c4ccncn4)O[C@@H]3C2)c1

$$$$
SWF001358
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001358

>  <SMILES>
O=C(c1cocn1)N1C[C@@H]2COC[C@]2(COc2ccccn2)C1

$$$$
SWF001359
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001359

>  <SMILES>
O=C(NCC1CC1)[C@H]1C[C@@H]2CCN(c3ncccn3)C[C@@H]2O1

$$$$
SWF001360
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  3  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001360

>  <SMILES>
Cn1cc(C(=O)N2C[C@@H]3COC[C@]3(COc3ccc(C#N)cn3)C2)cn1

$$$$
SWF001361
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -2.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -0.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11  9  1  1  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001361

>  <SMILES>
CS(=O)(=O)N1CC[C@H]2C[C@H](C(=O)NCc3ccccn3)O[C@@H]2C1

$$$$
SWF001362
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.9117   -3.9836   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001362

>  <SMILES>
O=C(NC1CC1)[C@@]12CCO[C@@H]1CCN(Cc1nccs1)C2

$$$$
SWF001363
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001363

>  <SMILES>
CCOC[C@]12COC[C@H]1CN(C(=O)c1cc(C)nc(C)c1)C2

$$$$
SWF001364
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6551    3.0878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    3.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    4.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001364

>  <SMILES>
Cc1nnc(N2C[C@H]3OCC[C@H]3[C@H](C(=O)NC3CC3)C2)s1

$$$$
SWF001365
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -2.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1277   -5.5468   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001365

>  <SMILES>
c1cncc(CN2C[C@@H]3COC[C@]3(COCc3ccncc3)C2)c1

$$$$
SWF001366
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 14 10  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001366

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1C[C@H]2OCC[C@H]2N(Cc2ccco2)C1

$$$$
SWF001367
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -1.2990   -6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001367

>  <SMILES>
CCN1CCn2c(C)cnc2C12CCN(c1ncccn1)CC2

$$$$
SWF001368
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10 16  2  0  0  0  0
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 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 13 15  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001368

>  <SMILES>
CN1C[C@H](COCc2ccccn2)[C@]2(CCN(Cc3ccccn3)C2)C1

$$$$
SWF001369
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  6  0  0  0
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 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001369

>  <SMILES>
Cn1cc(CN2CC[C@H]3OCC[C@@H](C(=O)NC4CCC4)[C@@H]3C2)cn1

$$$$
SWF001370
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 15  2  0  0  0  0
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 18 20  1  0  0  0  0
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 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  1  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001370

>  <SMILES>
O=C(N[C@H]1CN(Cc2ccncc2)[C@H]2CCCO[C@@H]12)c1cnccn1

$$$$
SWF001371
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001371

>  <SMILES>
O=C([C@H]1C[C@H]2OCC[C@H]2N(Cc2nccs2)C1)N1CCCC1

$$$$
SWF001372
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -4.7709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001372

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@H](C(=O)NC4CCC4)O[C@H]3C2)nn1

$$$$
SWF001373
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3783   -6.3666   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4002   -6.5745   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001373

>  <SMILES>
Cc1nc(CN2C(=O)CC[C@@H]3[C@H]2CCN3C(=O)c2ccccn2)cs1

$$$$
SWF001374
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9063   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0173   -4.9430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9443   -7.7961   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0136   -6.0577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4771   -7.4843   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
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  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001374

>  <SMILES>
c1ccc(CN2CCn3c(CN4CCCCC4)nnc3C2)nc1

$$$$
SWF001375
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001375

>  <SMILES>
CC(=O)N1CCNC(=O)C12CCN(Cc1cnn(C)c1)CC2

$$$$
SWF001376
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001376

>  <SMILES>
O=C1CC(c2ccncc2)C2(CCN(Cc3cccnc3)CC2)N1

$$$$
SWF001377
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001377

>  <SMILES>
Cc1ccc(CN2C[C@@H]3COC[C@]3(CNS(=O)(=O)C3CC3)C2)s1

$$$$
SWF001378
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001378

>  <SMILES>
Cc1ccccc1CC(=O)N1C[C@@H]2COC[C@]2(CN(C)C)C1

$$$$
SWF001379
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001379

>  <SMILES>
O=C1CC2(CCN(Cc3ccncc3)C2)CN1c1ccccn1

$$$$
SWF001380
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001380

>  <SMILES>
O=C1[C@H]2CN(Cc3cccnc3)C[C@@H]2CCN1Cc1cccnc1

$$$$
SWF001381
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
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 14 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF001381

>  <SMILES>
Cc1nc(COC[C@]23COC[C@H]2CN(C2CCOCC2)C3)cs1

$$$$
SWF001382
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 11 16  2  0  0  0  0
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 15 19  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001382

>  <SMILES>
O=C(c1ncccn1)N1CC[C@H]2OCC[C@@]2(COc2cccnc2)C1

$$$$
SWF001383
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207   -2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 13 16  1  6  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001383

>  <SMILES>
O=C(c1cocn1)N1CC[C@H]2OCC[C@@]2(COc2ccccn2)C1

$$$$
SWF001384
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001384

>  <SMILES>
Cc1cccc(N2CCCC3(CCN(Cc4ccncc4)C3=O)C2)n1

$$$$
SWF001385
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001385

>  <SMILES>
COC[C@H]1CN(CC2CC2)C[C@@]12CCN(C(=O)c1ccco1)C2

$$$$
SWF001386
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001386

>  <SMILES>
c1cnc(NC[C@H]2CCC[C@]3(CCN(Cc4nccs4)C3)O2)nc1

$$$$
SWF001387
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001387

>  <SMILES>
Cc1noc(C)c1CN1CCO[C@H]2CN(C(=O)c3ccccn3)C[C@H]21

$$$$
SWF001388
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001388

>  <SMILES>
COC[C@H]1CN(C)C[C@@]12CCN(Cc1cc(C)ccc1C)C2

$$$$
SWF001389
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
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 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001389

>  <SMILES>
Cn1cc(CN2C[C@@H]3COC[C@]3(COCC3CCC3)C2)cn1

$$$$
SWF001390
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.1226    3.2251   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4535    2.4820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001390

>  <SMILES>
O=C(c1ccc[nH]1)N1CCCC2(CCN(c3ccsc3)C2=O)C1

$$$$
SWF001391
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001391

>  <SMILES>
Cn1cccc1C(=O)N1C[C@@H]2COC[C@]2(CNS(C)(=O)=O)C1

$$$$
SWF001392
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001392

>  <SMILES>
Cn1cc(CN2CC[C@@]3(C[C@H](NC(=O)N4CCCC4)CCO3)C2)cn1

$$$$
SWF001393
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.8976    0.6423   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4781    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1617   -0.1652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3185   -1.6570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7606   -2.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499   -2.7097   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.1499   -4.9989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001393

>  <SMILES>
c1cncc(CN2CCOCC3(CCC(CN4CCCC4)O3)C2)c1

$$$$
SWF001394
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.2342    1.0606   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4842    2.3597   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3460   -0.3882   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
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 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  5  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001394

>  <SMILES>
Cc1cccc(CN2C[C@@H]3COC[C@]3(CC(=O)N3CC(F)(F)C3)C2)n1

$$$$
SWF001395
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
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 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001395

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccnnc2)[C@@H]2CN(Cc3ccco3)C[C@H]12

$$$$
SWF001396
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7  4  1  6  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001396

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(Cc3ccccn3)CC[C@H]21)N1CCCO1

$$$$
SWF001397
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1425   11.3784   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
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  9 10  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001397

>  <SMILES>
Cn1cc(CN2CC[C@H]3C[C@@H](C(=O)NCc4ccco4)O[C@@H]3C2)cn1

$$$$
SWF001398
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6172    0.9774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    2.5865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5307    1.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4262    2.3786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001398

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@]2(CCC[C@H](CN3CCCC3)O2)C1

$$$$
SWF001399
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001399

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cnccn2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF001400
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001400

>  <SMILES>
O=C(C1CCCO1)N1CCc2ncnc(Oc3cccnc3)c2CC1

$$$$
SWF001401
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3508    1.8499   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1599    1.2621   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5418    2.4377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9386    2.6589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
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  6  8  1  0  0  0  0
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  8 10  1  1  0  0  0
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 10 13  1  0  0  0  0
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 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001401

>  <SMILES>
CS(=O)(=O)N1CCC[C@]2(C[C@@H](OCc3ccccn3)CO2)C1

$$$$
SWF001402
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207   -2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162   -1.4013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9117   -2.9836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5049   -3.8971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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  9 12  1  0  0  0  0
  9 13  1  1  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001402

>  <SMILES>
O=C(C1CC1)N1CC[C@H]2OCC[C@@]2(COc2cccnc2)C1

$$$$
SWF001403
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4814   -5.2368   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5174   -4.9708   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5262   -6.2358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9665   -5.8054   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5900   -6.5872   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3608   -6.7867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001403

>  <SMILES>
Cc1ccoc1C(=O)N1C[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF001404
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9841    0.1157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2557   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.6292   -3.5249   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1292   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1656   -4.9515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3792   -5.8331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001404

>  <SMILES>
O=C(Cc1ccc(F)cc1)N1CC[C@@]2(C[C@@H](N3CCCC3)CCO2)C1

$$$$
SWF001405
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511   -2.2908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001405

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H](OCc3cccnc3)[C@H]3OCCC[C@H]32)o1

$$$$
SWF001406
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.4490   -2.9888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1292   -3.7219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1264   -3.6472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3950   -1.8653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2909   -2.3372   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9144   -1.5553   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.4754   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5490   -0.6245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001406

>  <SMILES>
c1cncc(CN2CCO[C@@H]3CN(Cc4ccoc4)CC[C@@H]3C2)c1

$$$$
SWF001407
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.5468   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -4.3005   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001407

>  <SMILES>
CNC(=O)[C@@H]1COC[C@H]2CN(C(=O)CCc3ccccc3)C[C@H]21

$$$$
SWF001408
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
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 10 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
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 13 15  1  1  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001408

>  <SMILES>
Cc1ccc(N2C[C@@H]3[C@@H](C2)OCC(=O)N3Cc2csc(C)n2)nn1

$$$$
SWF001409
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6425    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    4.4230   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6425    5.1730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1425    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    2.2172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1565    4.4231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001409

>  <SMILES>
Cc1ccnc(OC[C@]23COC[C@H]2CN(S(=O)(=O)C2CC2)C3)n1

$$$$
SWF001410
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1869   -5.4470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001410

>  <SMILES>
CCOC1COC2(CCN(C(=O)c3ccc(C)cn3)CC2)C1

$$$$
SWF001411
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
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  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001411

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@@H]3[C@H]2CCC(=O)N3CC2CC2)o1

$$$$
SWF001412
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
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  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  1  0  0  0
 15 18  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001412

>  <SMILES>
Cc1ccoc1C(=O)N1C[C@@H](OCC2CC2)[C@H]2OCCC[C@H]21

$$$$
SWF001413
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.0622   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6 10  1  0  0  0  0
  9 13  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001413

>  <SMILES>
COCCN1C[C@@H]2CCCO[C@@H]2[C@H](N(C)Cc2ccco2)C1

$$$$
SWF001414
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9952   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452   -5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9090    0.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2989    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3762   -0.0582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8071    1.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
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 14 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001414

>  <SMILES>
CCOCC1CN(S(=O)(=O)c2ccc(C)cc2)Cc2c1cnn2C

$$$$
SWF001415
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    4.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8768    4.4362   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005   -1.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  3  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001415

>  <SMILES>
Cc1ccoc1C(=O)N1C[C@@H]2COC[C@]2(COc2ccc(C#N)cn2)C1

$$$$
SWF001416
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6456   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8147    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3147   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3092   -0.2681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7160   -1.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  1  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001416

>  <SMILES>
CO[C@H]1CO[C@@]2(CCCN(C(=O)c3ccc(F)cc3C)C2)C1

$$$$
SWF001417
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.9345    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4345    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9345    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4345    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9400    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3412   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    0.6397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9733    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7133   -0.3114   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9733    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3862   -0.1441   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4907   -1.1386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 21 22  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001417

>  <SMILES>
Cn1cccc1C(=O)N1C[C@@H]2COC[C@]2(Cc2nnc(C3CC3)o2)C1

$$$$
SWF001418
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846   -3.1317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3481   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3563   -4.4015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4582   -5.9286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4584  -12.1530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0334  -12.3098   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3401  -13.3665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001418

>  <SMILES>
Cc1cccc(CN2CCC3(CCC(C(=O)N(C)C)O3)CC2)c1

$$$$
SWF001419
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.0371   -2.2634   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9506   -2.6701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7596   -2.0823   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0551   -3.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6732   -2.4890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9687   -4.0714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4822   -1.9013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1766   -5.0495   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 12  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001419

>  <SMILES>
O=C(Cc1ccco1)N1CC[C@H]2OCC[C@@]2(COCc2ccncc2)C1

$$$$
SWF001420
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4028   -1.5173   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1938    0.4717   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  1  0  0  0
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 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001420

>  <SMILES>
CS(=O)(=O)N1CCC2(CCC(C(=O)N3CCCO3)O2)CC1

$$$$
SWF001421
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001421

>  <SMILES>
c1cncc(CN2CC[C@]3(C[C@H](Oc4cccnc4)CO3)C2)c1

$$$$
SWF001422
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4303   -3.9240   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10 13  1  6  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 15 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001422

>  <SMILES>
CCS(=O)(=O)N1CC(C(=O)NCC2CC2)C2(CCOCC2)C1

$$$$
SWF001423
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 13 12  1  6  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001423

>  <SMILES>
O=C(c1ccco1)N1CCC[C@]2(C[C@@H](Oc3ncccc3F)CO2)C1

$$$$
SWF001424
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001424

>  <SMILES>
O=C(c1ccncn1)N1CCOC2CCC1C2OCC1CC1

$$$$
SWF001425
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3955    4.9136   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3736    4.7057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5646    3.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4782    3.7112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3567    2.3263   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001425

>  <SMILES>
Cc1ccsc1CN1CCC2(CCC(C(=O)N(C)C)O2)CC1

$$$$
SWF001426
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9955   -0.1932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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  7  8  1  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001426

>  <SMILES>
Cc1cccc(CO[C@@H]2CO[C@@]3(CCN(C(=O)C4CC4)C3)C2)n1

$$$$
SWF001427
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 21 24  2  0  0  0  0
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 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001427

>  <SMILES>
Cc1occc1C(=O)N1CC[C@H]2[C@H]1CC(=O)N2Cc1ccncc1

$$$$
SWF001428
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  8 13  1  0  0  0  0
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 10 16  2  0  0  0  0
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 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001428

>  <SMILES>
CC(=O)N1CCC2(CCOCC2NC(=O)c2ccccc2)CC1

$$$$
SWF001429
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    7.3972    0.9290   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5540   -0.5628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7676    1.5391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0213   -0.8747   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4393   -1.5665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7713    0.4244   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0794    3.0063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5961   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  6  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001429

>  <SMILES>
Cc1nnc([C@@H]2CO[C@@H]3CN(Cc4ccc5ccccc5n4)C[C@@H]32)o1

$$$$
SWF001430
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001430

>  <SMILES>
Cn1cc(CN2CCO[C@H]3[C@H](OCc4ccccn4)CC[C@@H]32)cn1

$$$$
SWF001431
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001431

>  <SMILES>
Cc1noc([C@H]2C[C@H]3OCC[C@H]3N(C(=O)c3cccs3)C2)n1

$$$$
SWF001432
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135    1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045    2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827    1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827    2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001432

>  <SMILES>
O=C(C[C@@H]1COC[C@H]2CN(Cc3ccncc3)C[C@@H]12)N1CCCC1

$$$$
SWF001433
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001433

>  <SMILES>
CN(C)CCN1CCC2(CCCN(C(=O)c3cnccn3)C2)C1=O

$$$$
SWF001434
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 16 17  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001434

>  <SMILES>
c1ccc(CN2C[C@@H]3COC[C@]3(CN3CCOCC3)C2)cc1

$$$$
SWF001435
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.8411    4.4196   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9202    3.0487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001435

>  <SMILES>
Cc1cccc(CN2CCOCC3(CCC(CN(C)C)O3)C2)n1

$$$$
SWF001436
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8712    2.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5622    3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622    3.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  7 10  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001436

>  <SMILES>
CN1CCN(CC2CC2)C(=O)C12CCN(C(=O)c1c[nH]cn1)CC2

$$$$
SWF001437
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7628   -1.1466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0299    0.4996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8507   -1.0257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7440   -0.9533   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3836   -2.0719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8300    1.0994   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6136   -1.9972   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2046   -0.0658   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7979    0.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2602   -2.7600   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2042   -0.0957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9229   -3.7014   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2441   -2.5814   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8159    0.6954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7675   -0.9219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5695   -4.4642   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8907   -3.3443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7573    0.3581   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7274   -0.6415   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5534   -4.2857   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001437

>  <SMILES>
O=C(O)[C@]12CCCN(C3CCOC3)C[C@H]1CN(c1ncccn1)C2

$$$$
SWF001438
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.1665    1.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0326    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3005    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001438

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@]2(C(=O)NCc2cccs2)C1

$$$$
SWF001439
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3291   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7190   -3.3681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8209   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6007   -4.5816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7026   -3.0545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0925   -4.4248   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001439

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CC1)CCN(C(=O)c1cccnc1)C2

$$$$
SWF001440
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.7543    2.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001440

>  <SMILES>
O=C(c1cccs1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF001441
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001441

>  <SMILES>
Cc1ncoc1C(=O)N1C[C@H]2CCC[C@@]2(COc2ccccn2)C1

$$$$
SWF001442
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11 13  1  1  0  0  0
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 17 18  1  6  0  0  0
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 22 24  2  0  0  0  0
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 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001442

>  <SMILES>
O=C(c1ccsc1)N1CCC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF001443
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001443

>  <SMILES>
O=C(c1cc(-c2ccnn2C2CCCC2)n2ccccc12)N1CCCCO1

$$$$
SWF001444
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001444

>  <SMILES>
COCC1CC2(CCN(Cc3cccc(F)c3)CC2)CN1C

$$$$
SWF001445
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001445

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccc[nH]3)CC2)CN1c1ncccn1

$$$$
SWF001446
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 20 23  1  6  0  0  0
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 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001446

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)CC(CC(=O)N(C)C)c2ccccc23)n1

$$$$
SWF001447
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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    8.8692    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001447

>  <SMILES>
CCOCCC1CCOC12CN(C(=O)CCc1ccccc1C)C2

$$$$
SWF001448
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    9.4267   -0.2150   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  1  0  0  0
 14 15  1  0  0  0  0
 23 25  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001448

>  <SMILES>
O=C(Nc1ccc2c(c1)OCO2)[C@H]1C[C@@H]2CN(c3ncc(F)cn3)C[C@H]1O2

$$$$
SWF001449
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001449

>  <SMILES>
CCC(=O)N1CCC2(COCc3cnc(-c4ccccc4)nc32)C1

$$$$
SWF001450
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  1  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 12  1  1  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001450

>  <SMILES>
CC(C)CNC(=O)[C@H]1C[C@@H]2CN(C(=O)Nc3ccccc3)C[C@H]1O2

$$$$
SWF001451
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.8498   -0.8149   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4431    0.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0418    1.1167   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  7 10  2  0  0  0  0
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 10 15  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 12  1  1  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001451

>  <SMILES>
CN(C)C(=O)[C@H]1C[C@@H]2CN(C(=O)Nc3ccccc3)C[C@H]1O2

$$$$
SWF001452
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001452

>  <SMILES>
CC(C)NC(=O)N1CCN(C(=O)c2cccnc2)CC2(CNC(=O)C2)C1

$$$$
SWF001453
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  5  8  2  0  0  0  0
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 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 14 17  1  0  0  0  0
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 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001453

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1C[C@@H]2CCN(Cc3ccoc3)C[C@H]2O1

$$$$
SWF001454
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 26 28  2  0  0  0  0
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 11 12  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001454

>  <SMILES>
CN(C)C(=O)N1C[C@@H]2C(=O)N(C)C3(CCN(C(=O)c4ccccc4)CC3)[C@@H]2C1

$$$$
SWF001455
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
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  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001455

>  <SMILES>
Cc1cccc(N2CC3(CCN(Cc4c(C)noc4C)C3)CC2=O)c1

$$$$
SWF001456
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3147   -4.3005   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  6  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001456

>  <SMILES>
O=C1[C@H]2CN(Cc3ccco3)C[C@@H]2CCN1Cc1cccnc1

$$$$
SWF001457
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  6  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001457

>  <SMILES>
CCOCC1COCCC12CCN(C(=O)Cc1ccc(C)cc1)CC2

$$$$
SWF001458
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
   10.3923   -2.2500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6423   -3.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1423   -3.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1914   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4414   -0.2010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001458

>  <SMILES>
O=C(CC1CC2(CCN(S(=O)(=O)C3CC3)CC2)Oc2ccccc21)N1CCCC1

$$$$
SWF001459
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.3736    4.7057   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.3955    4.9136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4782    3.7112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5646    3.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001459

>  <SMILES>
CC(C)CN1CCC2(CCN(C(=O)c3ccsc3)CC2)C1=O

$$$$
SWF001460
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1792   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5413   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9590   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9982   -6.9746   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  6  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001460

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccccn3)CC2)c2ccccc21)NC1CCC1

$$$$
SWF001461
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   11.0180    2.6181   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    2.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9162    4.1452   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4244    4.3020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8143    5.6723   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5427    3.0885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  9 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001461

>  <SMILES>
Cc1cccc(NC(=O)N2CCCC3(CC(C(=O)Nc4ccccc4)=NO3)C2)c1

$$$$
SWF001462
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2679   -8.6369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7321  -10.3690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7679   -9.5029   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 24 27  2  0  0  0  0
 26 28  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001462

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCN(C(=O)N(C)C)CC4)nn3c2)c1

$$$$
SWF001463
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001463

>  <SMILES>
COc1cccc(C(=O)N2CC[C@H](OC)[C@@H](Cc3ccccc3)C2)c1

$$$$
SWF001464
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001464

>  <SMILES>
O=C(c1ccccc1)N1CCC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF001465
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.3289    1.4318   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.3344    1.5363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9277    2.4499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001465

>  <SMILES>
CCO[C@@H]1CO[C@@]2(CCCN(C(=O)c3ccc(F)cc3C)C2)C1

$$$$
SWF001466
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2105   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0295   -4.5476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6118   -3.8431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 18  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001466

>  <SMILES>
Cc1cccc(C(=O)N2CCC[C@]3(C[C@H](Oc4ccccn4)CO3)C2)c1

$$$$
SWF001467
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0981    2.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  1  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001467

>  <SMILES>
O=C(CCc1ccccc1)N1CC[C@]2(C[C@@H](OCC3CCC3)CO2)C1

$$$$
SWF001468
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   12.8238   -1.6480   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9806   -3.1397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6103   -3.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2984   -5.2171   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001468

>  <SMILES>
CCOC1COC2(CCN(C(=O)c3cc(C)c(C)s3)CC2)C1

$$$$
SWF001469
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  6  0  0  0
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 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 24  2  0  0  0  0
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 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001469

>  <SMILES>
O=C(c1ccccc1)N1CC[C@H]2OCC[C@@]2(COc2ccccn2)C1

$$$$
SWF001470
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
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 13 17  1  6  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 13  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001470

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(CC3CC3)CC[C@H]21)NCc1cccnc1

$$$$
SWF001471
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001471

>  <SMILES>
COCC1CC2(CCN(C3CCC3)CC2)CN1Cc1cccnc1

$$$$
SWF001472
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001472

>  <SMILES>
c1cc(CN2CC[C@]3(CCC[C@H](CN4CCCC4)O3)C2)cs1

$$$$
SWF001473
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 12  8  1  1  0  0  0
 13  9  1  1  0  0  0
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 16 19  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001473

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(Cc3cccnc3)C[C@H]2O1)NCc1ccccn1

$$$$
SWF001474
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 15  2  0  0  0  0
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M  END
>  <HTSID>
SWF001474

>  <SMILES>
c1ccc(OCC2COCCC23CCN(c2ncccn2)CC3)nc1

$$$$
SWF001475
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001475

>  <SMILES>
O=S(=O)(NC[C@H]1CCC[C@]2(CCN(Cc3ccco3)C2)O1)C1CC1

$$$$
SWF001476
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001476

>  <SMILES>
O=C(c1cscn1)N1CCC2(CN(Cc3ccncc3)C2)C1

$$$$
SWF001477
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    7.4240    3.3534   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0036    2.4461   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001477

>  <SMILES>
CN(C)CC1COC2(COCCN(Cc3nccs3)C2)C1

$$$$
SWF001478
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.5793   -2.0773   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001478

>  <SMILES>
COCC1C(=O)NCC12CCN(Cc1cccc(C)n1)CC2

$$$$
SWF001479
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001479

>  <SMILES>
O=C(c1ccco1)N1C[C@@H]2COC[C@]2(COCC2CCCC2)C1

$$$$
SWF001480
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001480

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(c1ncccn1)C2)c1ccccc1

$$$$
SWF001481
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001481

>  <SMILES>
O=S(=O)(N[C@H]1CCO[C@]2(CCN(C3CCCC3)C2)C1)C1CC1

$$$$
SWF001482
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001482

>  <SMILES>
O=C(c1cscn1)N1CCC2(CN(Cc3cccnc3)C2)C1

$$$$
SWF001483
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF001483

>  <SMILES>
O=C(C1CC=CCC1)N1CC[C@@H]2O[C@@H](c3nnc(C4CC4)o3)C[C@H]2C1

$$$$
SWF001484
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001484

>  <SMILES>
COc1cc(N2C[C@@H]3COC[C@]3(CNC(=O)c3ccccc3)C2)ncn1

$$$$
SWF001485
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 14 10  1  1  0  0  0
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 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF001485

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccco2)C1

$$$$
SWF001486
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001486

>  <SMILES>
Cn1cc(N2CCC3(CCN(Cc4ccncc4)C3)C2=O)cn1

$$$$
SWF001487
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001487

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)NCCn1c(-c3ccccc3)cnc12

$$$$
SWF001488
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001488

>  <SMILES>
c1csc(CN2C[C@@H]3COC[C@]3(Cc3nnc(C4CC4)o3)C2)c1

$$$$
SWF001489
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    2.7309    5.4566   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001489

>  <SMILES>
CCC(=O)N1CC[C@]2(CCC[C@H](CNS(C)(=O)=O)O2)C1

$$$$
SWF001490
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001490

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(Cc3ccccc3)C2)O1

$$$$
SWF001491
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    2.7309    5.4566   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
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 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001491

>  <SMILES>
CCC(=O)N1CC[C@]2(CCC[C@@H](CNS(C)(=O)=O)O2)C1

$$$$
SWF001492
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.3846    7.6317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001492

>  <SMILES>
CC(C)C(=O)N1CCCC2(CN(Cc3cccs3)CCO2)C1

$$$$
SWF001493
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001493

>  <SMILES>
CS(=O)(=O)N1CCCCC12CCN(Cc1ccco1)CC2

$$$$
SWF001494
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11 15  2  0  0  0  0
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 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001494

>  <SMILES>
COc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccc2)C3)c1

$$$$
SWF001495
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001495

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CCN(CC(C)C)C3=O)o1

$$$$
SWF001496
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.7010    8.0408   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5442    6.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1682    8.3527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2452    5.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9182    7.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001496

>  <SMILES>
CN(C)C(=O)NCC1CC12CCN(Cc1nccs1)CC2

$$$$
SWF001497
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001497

>  <SMILES>
CS(=O)(=O)N1CC2CC(C(=O)NCc3ccccc3)C(C1)O2

$$$$
SWF001498
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001498

>  <SMILES>
Cc1ccc(CS(=O)(=O)N2CCC3(CC(=O)N(c4ccsc4)C3)C2)cc1

$$$$
SWF001499
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0514   -0.4612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 13 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 19 22  1  0  0  0  0
 10 14  1  0  0  0  0
 17 21  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001499

>  <SMILES>
COCC1c2nnn(C)c2CCN1C(=O)Cc1ccccn1

$$$$
SWF001500
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4010   -2.4042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001500

>  <SMILES>
O=C(Nc1ccccc1)C1CN(C(=O)c2ccccc2)CC12CCOCC2

$$$$
SWF001501
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5240    2.1133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10  7  1  1  0  0  0
 13 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001501

>  <SMILES>
CC(=O)N1CC(=O)N(c2ccccc2)CC12CCN(CC1CCOCC1)C2

$$$$
SWF001502
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3624   -5.0908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3187   -5.5067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6715   -6.0419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6496   -6.2498   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001502

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(C3CCOCC3)CC[C@H]21)Nc1cccnc1

$$$$
SWF001503
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.7788   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2788   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001503

>  <SMILES>
O=C([C@@H]1CO[C@@H]2CCN(Cc3cccs3)C[C@@H]2C1)N1CCCO1

$$$$
SWF001504
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  1  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001504

>  <SMILES>
Cc1cc(C(=O)N2CC[C@]3(C[C@@H](OCc4cccnc4)CO3)C2)no1

$$$$
SWF001505
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3081    3.4465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001505

>  <SMILES>
O=C1CCCN1[C@H]1CCO[C@]2(CCN(Cc3ccco3)C2)C1

$$$$
SWF001506
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.4347    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001506

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(C3CCC3)CC[C@H]21)NCc1cccs1

$$$$
SWF001507
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001507

>  <SMILES>
Cc1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)Nc3cccnc3)C2)no1

$$$$
SWF001508
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001508

>  <SMILES>
COCCN1CC2(CCN(C(=O)C3CC=CC3)CC2)CC1COC

$$$$
SWF001509
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5493   -1.3329   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3414   -0.3547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
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  2  5  1  0  0  0  0
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  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001509

>  <SMILES>
c1ccc(O[C@H]2CC[C@H]3[C@H]2OCCN3Cc2ccoc2)nc1

$$$$
SWF001510
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 21 26  1  0  0  0  0
 22 27  1  0  0  0  0
 23 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001510

>  <SMILES>
Cn1cnc2c(-c3ccccc3)nc(C3CCN(C(=O)c4ccoc4)CC3)cc21

$$$$
SWF001511
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6078    4.0556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 16 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 15  1  0  0  0  0
 14 19  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001511

>  <SMILES>
CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1cccnc1OC

$$$$
SWF001512
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.6444   -0.6112   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.9753    0.1320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  1  0  0  0
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 16 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001512

>  <SMILES>
CCO[C@H]1CC[C@H]2[C@@H]1OCCN2C(=O)c1ccc(F)c(OC)c1

$$$$
SWF001513
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.5418   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  7  4  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001513

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(Cc4cc(C)c(C)o4)C[C@H]3O2)no1

$$$$
SWF001514
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.4309   -4.3765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4560   -4.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001514

>  <SMILES>
CC(C)N1CCOCC2(CN(C(=O)c3cccnc3)CCO2)C1

$$$$
SWF001515
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3280    0.6672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9972   -0.0759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2843    1.0830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5  3  1  1  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001515

>  <SMILES>
O=C(c1ccccn1)N1CCO[C@H]2[C@@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF001516
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491   -1.6910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491   -3.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8581   -4.2601   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5827   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  6  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001516

>  <SMILES>
CO[C@H]1CC[C@H]2[C@H]1OCCN2C(=O)CC1Cc2ccccc2C1

$$$$
SWF001517
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4291    0.6401   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2952    0.1401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0383    0.8092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  2  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001517

>  <SMILES>
O=C(c1ccco1)N1CCO[C@H]2[C@@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF001518
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3280    0.6672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2843    1.0830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9753    0.1320   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 11  1  0  0  0  0
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  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001518

>  <SMILES>
O=C(c1ccncc1)N1CCO[C@H]2[C@@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF001519
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072    3.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 12  1  6  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 13  9  1  1  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001519

>  <SMILES>
Cc1nccc([C@@H]2C[C@@H]3CCN(C(=O)CN(C)C)C[C@H]3O2)n1

$$$$
SWF001520
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF001520

>  <SMILES>
O=C(NC1CC1)[C@H]1C[C@@H]2CCN(CCN3CCCC3)C[C@H]2O1

$$$$
SWF001521
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1277   -2.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 18 22  2  0  0  0  0
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 21 24  2  0  0  0  0
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  8  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001521

>  <SMILES>
c1ccc(CN2C[C@@H]3COC[C@]3(COCc3ccccn3)C2)cc1

$$$$
SWF001522
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF001522

>  <SMILES>
O=C(c1ccco1)N1CCCC12CCN(Cc1nccs1)CC2

$$$$
SWF001523
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 12 13  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001523

>  <SMILES>
O=C(c1ccco1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF001524
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 13  2  0  0  0  0
 16 19  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001524

>  <SMILES>
Cc1noc([C@]23COC[C@H]2CN(C(=O)c2ccnn2C)C3)n1

$$$$
SWF001525
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  2  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001525

>  <SMILES>
Cc1noc(C)c1C(=O)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF001526
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    4.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    5.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001526

>  <SMILES>
c1ccc(CO[C@@H]2CO[C@@]3(CCN(Cc4ccccn4)C3)C2)nc1

$$$$
SWF001527
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001527

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CC1)COC(COc1cccnc1)C2

$$$$
SWF001528
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.6808    2.9345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468    2.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147    3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1808    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11  9  1  1  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001528

>  <SMILES>
CS(=O)(=O)N1CC[C@H]2C[C@@H](C(=O)Nc3cccnc3)O[C@H]2C1

$$$$
SWF001529
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2321   -3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5411   -3.9899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0770   -3.9899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -4.5777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5981   -6.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981   -7.0777   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4641   -5.5777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4641   -7.5777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301   -6.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301   -7.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001529

>  <SMILES>
O=C(Cc1ccco1)N1CC[C@]2(C[C@@H](Oc3ccccn3)CO2)C1

$$$$
SWF001530
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.0782    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5782   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001530

>  <SMILES>
c1ccc(CO[C@H]2CO[C@@]3(CCN(Cc4ccoc4)C3)C2)nc1

$$$$
SWF001531
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.4431    0.0986   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.3386   -0.8959   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001531

>  <SMILES>
O=C(Nc1ccccc1)[C@H]1C[C@@H]2CN(S(=O)(=O)c3ccccc3)C[C@H]1O2

$$$$
SWF001532
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001532

>  <SMILES>
Cc1cccc(NC(=O)c2cc3c(c4ccccc4n3C)n2-c2ncccn2)c1

$$$$
SWF001533
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF001533

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@@]2(C[C@@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001534
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF001534

>  <SMILES>
Cc1cccc(COC[C@]23COC[C@H]2CN(C(=O)c2ccco2)C3)n1

$$$$
SWF001535
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001535

>  <SMILES>
CN(C)CC(=O)N1CC[C@]2(C[C@@H](OCc3cccnc3)CO2)C1

$$$$
SWF001536
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.6403    0.7498   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0455    2.2295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2407   -3.7555   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3184   -3.5427   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF001536

>  <SMILES>
CC(C)NC(=O)N1CCN(C(=O)c2ccco2)CC2(CC(=O)N(C)C2)C1

$$$$
SWF001537
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -3.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391   -3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301   -4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3956   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301   -5.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  1  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  2  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001537

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cc3ccccc3o2)[C@H]2CCO[C@H]12

$$$$
SWF001538
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.2617    3.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7383    1.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2383    0.7167   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 13 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001538

>  <SMILES>
O=C(Cc1ccccc1)N1C[C@@H]2COC[C@]2(COc2cccnc2)C1

$$$$
SWF001539
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  5  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001539

>  <SMILES>
Cn1cc(-c2ncnc3c2CCN(C(=O)c2ccsc2)CC3)cn1

$$$$
SWF001540
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0475    1.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    0.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7167    0.6636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2167   -0.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001540

>  <SMILES>
CC(C)Nc1nc2c(cc1C(=O)N1CCCC1)CCNCC2

$$$$
SWF001541
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001541

>  <SMILES>
Cc1nc(CN2C(=O)CC[C@@H]3[C@H]2CCN3Cc2ccc(F)cc2)cs1

$$$$
SWF001542
Actelion Java MolfileCreator 1.0

 32 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001542

>  <SMILES>
CCN(CC)C(=O)CC1CC2(CCN(C(=O)c3ccc(C)cc3)CC2)Oc2ccccc21

$$$$
SWF001543
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF001543

>  <SMILES>
c1ccc(OC[C@@]23CCO[C@@H]2CCN(c2ncccn2)C3)nc1

$$$$
SWF001544
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001544

>  <SMILES>
CCOc1ccc(CC(=O)N2CC[C@@H]3O[C@@H](C)C[C@H]3C2)cc1

$$$$
SWF001545
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001545

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccsc2)[C@@H]2CN(CC3CC3)C[C@H]12

$$$$
SWF001546
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF001546

>  <SMILES>
c1ccc(CO[C@@H]2CCN(Cc3cccnc3)[C@H]3CCO[C@H]23)nc1

$$$$
SWF001547
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001547

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(C(=O)Nc1ccc(Cl)cc1)C2

$$$$
SWF001548
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 19  1  0  0  0  0
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 19 21  2  0  0  0  0
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 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001548

>  <SMILES>
CS(=O)(=O)N1CCOC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF001549
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001549

>  <SMILES>
O=C1CCC2(CCN(c3cccnc3)CC2)N1Cc1ccncc1

$$$$
SWF001550
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
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 23 26  1  0  0  0  0
 13 17  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001550

>  <SMILES>
O=C1CCCN1Cc1ncn2c1CN(S(=O)(=O)c1ccccc1)CCC2

$$$$
SWF001551
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001551

>  <SMILES>
Cc1ncsc1CN1CCO[C@H]2[C@H](OCC3CCCC3)CC[C@@H]21

$$$$
SWF001552
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001552

>  <SMILES>
O=C(c1ccccc1F)N1CCC(c2nc3ccc(N4CCOCC4)cn3n2)C1

$$$$
SWF001553
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001553

>  <SMILES>
Cc1nocc1C(=O)N1CCC2(CC1)Cc1nn(Cc3ccc(F)cc3)c(=O)c(=O)n1C2

$$$$
SWF001554
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001554

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCC2(CC1)Cc1nn(Cc3ccc(F)cc3)c(=O)c(=O)n1C2

$$$$
SWF001555
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001555

>  <SMILES>
CC1(C(=O)N2C[C@H]3CN(CC4CC4)C(=O)[C@H]3C2)CC=CCC1

$$$$
SWF001556
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  5  1  6  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
 23 27  1  0  0  0  0
 24 28  2  0  0  0  0
 26 29  1  0  0  0  0
 27 30  2  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001556

>  <SMILES>
CC(C)NC(=O)N1CCC2(CCn3c2nc2c(c3=O)CN(C(=O)c3ccncc3)CC2)C1

$$$$
SWF001557
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.8073    2.5340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8018    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3896    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1867    1.3080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3773    3.3949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2912    0.3135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001557

>  <SMILES>
CN1C[C@@H](COCc2ccccn2)[C@]2(CCN(C(=O)C3CC(O)C3)C2)C1

$$$$
SWF001558
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5711   -0.8907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001558

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CC(N(C)Cc1ccco1)CO2

$$$$
SWF001559
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001559

>  <SMILES>
O=C(NCC1CC1)C1Cn2ccnc2C2(CCN(Cc3ccccn3)CC2)O1

$$$$
SWF001560
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  6  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 23 26  2  0  0  0  0
  7  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001560

>  <SMILES>
c1ccc(CN2CCOC3(COCCN(Cc4ccncc4)C3)C2)nc1

$$$$
SWF001561
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    5.6808   -5.4969   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001561

>  <SMILES>
COCCNC(=O)[C@@]12CCO[C@@H]1CCN(C(=O)c1ccncc1OC)C2

$$$$
SWF001562
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001562

>  <SMILES>
Cc1ccc(C(=O)N2Cc3cn(C(C)C)nc3C3(CCN(c4ncccn4)CC3)C2)cc1

$$$$
SWF001563
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001563

>  <SMILES>
CS(=O)(=O)N1CCn2c(-c3ccccc3)cnc2C12CCN(Cc1ccco1)CC2

$$$$
SWF001564
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001564

>  <SMILES>
O=C(c1ccsc1)N1CC2CN(c3ccccc3)C(=O)C2C1

$$$$
SWF001565
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001565

>  <SMILES>
CN1CCC2(c3ccccc3)CCN(C(=O)c3ccco3)CC12

$$$$
SWF001566
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
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 23 24  2  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF001566

>  <SMILES>
O=C(NCc1ccccn1)C1Cn2ccnc2C2(CCN(C(=O)Nc3ccccc3)CC2)O1

$$$$
SWF001567
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
 15 17  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001567

>  <SMILES>
Cc1ccc(NC(=O)c2cc(-c3cnc(N(C)C)nc3)cn2CC2CC2)cc1Cl

$$$$
SWF001568
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 30 32  2  0  0  0  0
M  END
>  <HTSID>
SWF001568

>  <SMILES>
COc1ccc(F)cc1-c1ccc2nc(C3CCCN(C(=O)c4cccn4C)C3)nn2c1

$$$$
SWF001569
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001569

>  <SMILES>
CC(=O)N1CC2C(C1)n1cccc1C(=O)N2Cc1ccccc1

$$$$
SWF001570
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 12  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001570

>  <SMILES>
Cc1ccoc1C(=O)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF001571
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001571

>  <SMILES>
c1ccc(O[C@@H]2CC[C@H]3[C@H]2OCCN3CC2CCOCC2)nc1

$$$$
SWF001572
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001572

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)c4ccco4)CC3)OCC2=O)cn1

$$$$
SWF001573
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
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 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 30 32  2  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF001573

>  <SMILES>
O=C(NCc1ccccc1)C1Cn2ccnc2C2(CCN(C(=O)c3ccccc3)CC2)O1

$$$$
SWF001574
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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  8 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  2  0  0  0  0
 14 16  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001574

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1cccnc1)C2)c1ccco1

$$$$
SWF001575
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001575

>  <SMILES>
COc1ccc(F)cc1-c1ccc2nc(C3CCCNC3)nn2c1

$$$$
SWF001576
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  7 10  2  0  0  0  0
  8 11  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001576

>  <SMILES>
CNC(=O)c1cc2c(nc1N(C)C)CCN(c1ncccn1)CC2

$$$$
SWF001577
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
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 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001577

>  <SMILES>
c1coc(CN2CCC(c3nc4ccc(-c5ccncc5)cn4n3)CC2)c1

$$$$
SWF001578
Actelion Java MolfileCreator 1.0

 33 38  0  0  0  0  0  0  0  0999 V2000
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 31 33  1  0  0  0  0
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 18 20  1  0  0  0  0
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 29 31  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF001578

>  <SMILES>
O=C(c1ccc2c(c1)OCO2)N1Cc2ccccc2C2(CCN(c3ncc(F)cn3)CC2)C1

$$$$
SWF001579
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001579

>  <SMILES>
Cn1cc(N2CC3(COCCN(C(=O)c4cccs4)C3)OCC2=O)cn1

$$$$
SWF001580
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001580

>  <SMILES>
O=C1CC[C@@H]2[C@@H](CCN2Cc2cccnc2)N1c1ccccc1

$$$$
SWF001581
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001581

>  <SMILES>
Cc1nc(COCC2CCOC23CN(c2cc(N(C)C)ncn2)C3)cs1

$$$$
SWF001582
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001582

>  <SMILES>
CS(=O)(=O)N1CCC[C@]2(C[C@@H](OCc3cccnc3)CO2)C1

$$$$
SWF001583
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001583

>  <SMILES>
CC(=O)NCC(=O)N1CC[C@H](OCC2CC2)[C@@H]1Cc1ccccc1

$$$$
SWF001584
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001584

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCCN(C(=O)c5ccco5)C4)nn3c2)c1OC

$$$$
SWF001585
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001585

>  <SMILES>
CNC(=O)[C@H]1CCO[C@H]2CCN(Cc3cccc(C)n3)C[C@@H]21

$$$$
SWF001586
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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  6 10  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001586

>  <SMILES>
c1ccc(CN2C[C@@H]3CCCO[C@@H]3[C@H](N3CCCC3)C2)nc1

$$$$
SWF001587
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001587

>  <SMILES>
Cc1noc(C)c1CN1CC2CC(C(=O)NCc3cccnc3)C(C1)O2

$$$$
SWF001588
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF001588

>  <SMILES>
CC(C)CC(=O)N1CC[C@@H]2[C@H](CC1)N(CC(C)C)CCS2(=O)=O

$$$$
SWF001589
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001589

>  <SMILES>
Cc1ccc(CN2CC3CC(C(=O)N4CCCC4)C(C2)O3)o1

$$$$
SWF001590
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001590

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(C(=O)c1cnccn1)C2

$$$$
SWF001591
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001591

>  <SMILES>
CCN1C(=O)CCC12CCCN(Cc1ccc(F)cc1)CC2

$$$$
SWF001592
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    5.8910    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001592

>  <SMILES>
O=C(Cc1ccc2c(c1)CCCO2)N1CC2(C1)C(COc1ncccn1)CCS2(=O)=O

$$$$
SWF001593
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001593

>  <SMILES>
Cc1ccsc1C(=O)N1CCC2(CC2C(=O)NCc2cccnc2)C1

$$$$
SWF001594
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001594

>  <SMILES>
CN1CC(=O)N(c2ccccc2)CC12CCN(Cc1cccnc1)C2

$$$$
SWF001595
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
    8.4470    2.1858   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001595

>  <SMILES>
Cc1ccccc1CC(=O)N1CCOC[C@@H](CCN(C)C)[C@@H]1C

$$$$
SWF001596
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001596

>  <SMILES>
CNC(=O)CC1CC2(CCN(C(=O)c3ccccn3)CC2)Oc2ccccc21

$$$$
SWF001597
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001597

>  <SMILES>
Cc1ccc(N2CCN(CC(C)C)C3(CCN(Cc4ccccn4)CC3)C2=O)cn1

$$$$
SWF001598
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001598

>  <SMILES>
Cn1cc(N2CC3(CCN(Cc4nccn4C)C3)CC2=O)cn1

$$$$
SWF001599
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001599

>  <SMILES>
Cc1cccc(CN2C(=O)C[C@H]3[C@@H]2CCN3C(=O)c2cccs2)n1

$$$$
SWF001600
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001600

>  <SMILES>
O=C1COC2(COCCN(Cc3ccccn3)C2)CN1c1ccoc1

$$$$
SWF001601
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    6.9128    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 18  2  0  0  0  0
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 18 21  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001601

>  <SMILES>
CC1c2nc(CC(=O)NCC3CC3)cn2CCN1C(=O)c1c[nH]c2ccccc12

$$$$
SWF001602
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 19 20  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001602

>  <SMILES>
O=C(Nc1ccc(F)cc1)N1CCCn2cnc(CN3CCCC3)c2C1

$$$$
SWF001603
Actelion Java MolfileCreator 1.0

 31 36  0  0  0  0  0  0  0  0999 V2000
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 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF001603

>  <SMILES>
O=C(NCc1cccs1)c1cc2c(c3ccccc3n2CC2CC2)n1-c1ncccn1

$$$$
SWF001604
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001604

>  <SMILES>
CCS(=O)(=O)NCCC1CCOC12CN(Cc1cnn(C)c1)C2

$$$$
SWF001605
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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   -0.1569   -2.2438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2028   -9.3198   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3762   -1.2558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6255   -2.5560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 24 27  1  0  0  0  0
 24 28  2  0  0  0  0
 25 29  2  0  0  0  0
 27 30  1  0  0  0  0
 28 31  1  0  0  0  0
 11 13  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  2  0  0  0  0
 26 29  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <HTSID>
SWF001605

>  <SMILES>
CS(=O)(=O)N1CCn2c(-c3ccccc3)cnc2C12CCN(C(=O)c1cccs1)CC2

$$$$
SWF001606
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001606

>  <SMILES>
COc1ccc(CN2CC[C@@H]3[C@@H](CO[C@@H]3CNC(=O)C3CC3)C2)cc1

$$$$
SWF001607
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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   11.6277    0.0447   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 21 26  1  0  0  0  0
 22 27  1  0  0  0  0
 23 28  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  2  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF001607

>  <SMILES>
Cc1ccsc1CN1CC(c2nccs2)C2(CCN(Cc3cccs3)C2=O)C1

$$$$
SWF001608
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001608

>  <SMILES>
Cc1cnc(C(=O)N2C[C@@H]3OCCN(Cc4ccc(C)o4)[C@@H]3C2)cn1

$$$$
SWF001609
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001609

>  <SMILES>
Cc1noc(C)c1CN1CCCC2(CCN(C(=O)c3ccnnc3)C2)C1

$$$$
SWF001610
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5185    2.2178   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001610

>  <SMILES>
O=C1N(Cc2ccccn2)CCC12CCN(CC1CCOCC1)CC2

$$$$
SWF001611
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.0550    1.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7242    0.7601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7777   -4.4836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001611

>  <SMILES>
CC(=O)N1CCC2(c3ccccc3)CCN(Cc3ccccn3)CC12

$$$$
SWF001612
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0456   -4.4836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001612

>  <SMILES>
CN1CCC2(c3ccccc3)CCN(Cc3cccnc3)CC12

$$$$
SWF001613
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.0841   -2.2458   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3518    5.2528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2621    6.7502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6934    4.5819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  2  0  0  0  0
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 13 18  2  0  0  0  0
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 16 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 27 30  2  0  0  0  0
 10 12  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001613

>  <SMILES>
COCCN1Cc2c(C(=O)Nc3ccccc3C)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF001614
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  1  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 13 14  1  6  0  0  0
 16 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001614

>  <SMILES>
O=C(C1CC=CC1)N1C[C@H](Oc2ncccc2F)[C@H]2OCCC[C@H]21

$$$$
SWF001615
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001615

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF001616
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0327   -1.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF001616

>  <SMILES>
CNC(=O)CC1CN(C(=O)c2occc2C)Cc2ccnn21

$$$$
SWF001617
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.5111   -5.1119   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001617

>  <SMILES>
CN(C)CC1CN(Cc2cccc(C#N)c2)Cc2nccn2C1

$$$$
SWF001618
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001618

>  <SMILES>
O=C(NCc1cnc2n1CCN(Cc1ccoc1)C2)c1ccno1

$$$$
SWF001619
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001619

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)C4CC(O)C4)C[C@H]32)cs1

$$$$
SWF001620
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001620

>  <SMILES>
Cc1ccc(CN2C[C@@H](C(=O)N3CCCC3)C[C@H]3OCC[C@H]32)o1

$$$$
SWF001621
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001621

>  <SMILES>
Cc1ccccc1C(=O)N1CC2C(C1)n1cccc1C(=O)N2Cc1ccccn1

$$$$
SWF001622
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.2256   -5.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001622

>  <SMILES>
CN(C)CCOCc1cncc2c1CCN(Cc1cccs1)C2

$$$$
SWF001623
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001623

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3[C@H](C2)n2cccc2C(=O)N3Cc2ccccc2)cs1

$$$$
SWF001624
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001624

>  <SMILES>
CS(=O)(=O)NCc1cncc2c1CCN(C(=O)c1ccoc1)C2

$$$$
SWF001625
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001625

>  <SMILES>
O=C(NCc1ccc(F)cc1)C1=NOC2(CCN(Cc3cccs3)C2)C1

$$$$
SWF001626
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.9282    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5263    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0981    3.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001626

>  <SMILES>
CC(C)Nc1nc2c(c(NC3CC3)n1)CN(C(=O)c1ccncc1)CC2

$$$$
SWF001627
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.9339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8311   -1.9339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8555   -2.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6086   -2.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.6906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.6906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -4.5567   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2321   -5.4227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -5.4227   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2679   -4.5567   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6340   -5.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7679   -6.4227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001627

>  <SMILES>
O=C(NC1CCCC1)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF001628
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7759   -2.5577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0223    1.8291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001628

>  <SMILES>
C[C@H]1CN(c2ccccn2)C[C@@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF001629
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 16  1  0  0  0  0
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 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001629

>  <SMILES>
COc1cccc(C(=O)N2CCc3nc(N4CCCC4)nc(C)c3CC2)c1

$$$$
SWF001630
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001630

>  <SMILES>
FC1(F)CCN(Cc2ccsc2)CC12CCN(c1cnccn1)C2

$$$$
SWF001631
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001631

>  <SMILES>
O=S(=O)(C1CC1)N1CCC(F)(F)C2(CCN(c3cnccn3)C2)C1

$$$$
SWF001632
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
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 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001632

>  <SMILES>
COCC(=O)NC1CC2(CCN(CC#N)CC2)Oc2ccccc21

$$$$
SWF001633
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4636   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4673    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  8  1  1  0  0  0
 12  9  1  1  0  0  0
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 20 22  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001633

>  <SMILES>
COCCNC(=O)C[C@H]1C[C@H]2CN(Cc3ccco3)C[C@H]2O1

$$$$
SWF001634
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6804   -4.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001634

>  <SMILES>
O=C(c1ccncn1)N1CC[C@@]2(C[C@@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001635
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 17 20  1  0  0  0  0
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  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001635

>  <SMILES>
O=C1C[C@@H]2[C@H](CCN2CC2CCOCC2)N1Cc1ccncc1

$$$$
SWF001636
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -3.7128   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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 10  8  1  6  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 16 13  1  1  0  0  0
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 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001636

>  <SMILES>
O=C(NCc1cccs1)[C@@H]1C[C@H]2OCC[C@H]2N(C2CCOCC2)C1

$$$$
SWF001637
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   16.9588   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   15.5885   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.9625   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7452   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.2125   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001637

>  <SMILES>
COCCNC(=O)[C@H]1CO[C@H]2CCN(Cc3cccs3)C[C@H]2C1

$$$$
SWF001638
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4729   -8.1174   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8432   -7.5072   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4692   -7.0026   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2192   -5.7036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9774   -7.1594   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8011   -5.0118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4892   -3.5445   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6040   -2.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0627   -3.0810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2921   -1.0736   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001638

>  <SMILES>
Cc1cc(CN2CCC3(CC2)OCCC3CCOCc2ccccn2)no1

$$$$
SWF001639
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 17 15  1  1  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001639

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(C(=O)Cc4cccc(F)c4)C[C@H]3O2)no1

$$$$
SWF001640
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8  7  1  1  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001640

>  <SMILES>
COc1ccc(CN2C(=O)CO[C@@H]3CN(CC(=O)O)C[C@H]32)cc1

$$$$
SWF001641
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -2.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001641

>  <SMILES>
CS(=O)(=O)N1CC[C@H]2C[C@H](C(=O)NCc3ccco3)O[C@H]2C1

$$$$
SWF001642
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.3454    1.7454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001642

>  <SMILES>
O=C(Cc1ccco1)N1CCC[C@]2(C[C@@H](OCC3CC3)CO2)C1

$$$$
SWF001643
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001643

>  <SMILES>
O=C(c1ccncc1)N1CCO[C@H]2[C@@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF001644
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.4098   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001644

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(C(=O)NC(C)C)C[C@@H]32)C(=O)N1C

$$$$
SWF001645
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001645

>  <SMILES>
O=C(c1ccncn1)N1C[C@@H](OCC2CC2)[C@H]2OCCC[C@H]21

$$$$
SWF001646
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.8848    1.1896   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001646

>  <SMILES>
CNC(=O)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccc(F)c(F)c2)O1

$$$$
SWF001647
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    6.1312    3.1740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001647

>  <SMILES>
Cc1nc(CO[C@@H]2CO[C@@]3(CCN(CCc4ccccc4)C3)C2)cs1

$$$$
SWF001648
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  4  7  2  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001648

>  <SMILES>
O=C(c1cccnc1)N1C[C@@H]2COC[C@]2(COCc2ccccn2)C1

$$$$
SWF001649
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001649

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@@H]2CCN(Cc3ccoc3)C[C@@H]2O1

$$$$
SWF001650
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001650

>  <SMILES>
O=C(c1ccccn1)N1CC[C@@]2(C[C@@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001651
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001651

>  <SMILES>
O=C(c1ccoc1)N1CC[C@@]2(C[C@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001652
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001652

>  <SMILES>
COCC1C(=O)NCC12CCN(C(=O)Cc1ccccc1)CC2

$$$$
SWF001653
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001653

>  <SMILES>
Cc1csc(CN2CC[C@H]3C[C@H](c4nnc(C5CC5)o4)O[C@@H]3C2)n1

$$$$
SWF001654
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 16 17  1  0  0  0  0
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 21 22  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001654

>  <SMILES>
CC(C)NC(=O)[C@H]1CN(Cc2cnn(C)c2)C[C@H]2OCC[C@@H]12

$$$$
SWF001655
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 10  1  6  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001655

>  <SMILES>
Cc1nc(CN2CC3(CCN(Cc4ccoc4)C3)CC2=O)cs1

$$$$
SWF001656
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    2.6694   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6731    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   15.7232   -0.7619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
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 12  8  1  1  0  0  0
 13  9  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001656

>  <SMILES>
Cc1ccc(N2C[C@@H]3C[C@@H](c4nnc(C5CC5)o4)O[C@@H]3C2)nn1

$$$$
SWF001657
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001657

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccoc1)C2)c1ccnnc1

$$$$
SWF001658
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -2.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001658

>  <SMILES>
Cn1cc2c(n1)C(COCC1CC1)CN(Cc1ccncc1)C2

$$$$
SWF001659
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5646    3.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3955    4.9136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4782    3.7112   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3736    4.7057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001659

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(C(=O)c3ccoc3)CC2)O1

$$$$
SWF001660
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.5262    3.5103   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2693    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0614    1.8630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2204    3.1502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1104    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8046    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0294    2.5624   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5294    4.1013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9025    0.5759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5967    0.2158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8384    3.1502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5294    4.1013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7895    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001660

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CCCN3CC3CC3)CC2)o1

$$$$
SWF001661
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3404   -4.1266   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0314   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6192   -5.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  8  5  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001661

>  <SMILES>
Cc1ccc(CN2C[C@@H]3C[C@H](Cc4nnc(C)o4)O[C@@H]3C2)o1

$$$$
SWF001662
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    7.9090    1.9456   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5782    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1000    0.5443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001662

>  <SMILES>
CN1CCN(C(=O)C[C@H]2C[C@H]3CN(Cc4nccs4)C[C@H]3O2)CC1

$$$$
SWF001663
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2135   -7.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001663

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccoc2)C1

$$$$
SWF001664
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7629    0.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
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 14 18  1  0  0  0  0
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  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001664

>  <SMILES>
O=C(c1ccnnc1)N1C[C@H](OCC2CCCC2)[C@H]2OCCC[C@H]21

$$$$
SWF001665
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.8417    0.9067   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.9282    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5109    0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0327   -0.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  6  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001665

>  <SMILES>
CN(Cc1cccnc1)CC1CC12CCN(Cc1nccs1)CC2

$$$$
SWF001666
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2652    4.0061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001666

>  <SMILES>
COC[C@H]1CN(C)C[C@@]12CCN(C(=O)c1ccccc1C)C2

$$$$
SWF001667
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.0981    2.5388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  2  0  0  0  0
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 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001667

>  <SMILES>
Cc1ccc(C(=O)N2CCOCC2c2csc(C)n2)cn1

$$$$
SWF001668
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001668

>  <SMILES>
Cc1noc(C)c1CN1CCC[C@]2(C[C@H](OCC(=O)N(C)C)CO2)C1

$$$$
SWF001669
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3400   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001669

>  <SMILES>
O=C(c1ccccc1)N1CC[C@@H]2CN(Cc3ccccc3)S(=O)(=O)[C@@H]2CC1

$$$$
SWF001670
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9378    4.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3081    3.4465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001670

>  <SMILES>
Cc1ccccc1CN1CC[C@@]2(C[C@H](N3CCCC3=O)CCO2)C1

$$$$
SWF001671
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5870    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  2  0  0  0  0
  8 13  1  1  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001671

>  <SMILES>
O=C(C[C@]12COC[C@H]1CN(Cc1cccnc1)C2)NCc1ccco1

$$$$
SWF001672
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 13  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001672

>  <SMILES>
O=C(C[C@]12COC[C@H]1CN(Cc1cccnc1)C2)N1CCCCO1

$$$$
SWF001673
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001673

>  <SMILES>
Cc1ccc(C(=O)N2CCc3c(COCCN(C)C)cncc3C2)o1

$$$$
SWF001674
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001674

>  <SMILES>
CCOCC1COCCC12CCN(Cc1ccccc1)CC2

$$$$
SWF001675
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF001675

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@@]2(C[C@@H](N3CCCC3)CCO2)C1

$$$$
SWF001676
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF001676

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1CC[C@@H]2[C@@H](CCN2c2ncccn2)O1

$$$$
SWF001677
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.4417   -5.3566   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001677

>  <SMILES>
Fc1cnc(N2C[C@@H](Oc3ccccn3)[C@H]3OCCC[C@H]32)nc1

$$$$
SWF001678
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF001678

>  <SMILES>
O=C(c1ccco1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF001679
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001679

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1C[C@@H]2CCN(Cc3ccco3)C[C@H]2O1

$$$$
SWF001680
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001680

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cnn(C)c2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF001681
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.2350   -1.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2350   -0.1340   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7350    0.7321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2350    1.5981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350    0.7321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7350    2.4641   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2350    1.5981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
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 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001681

>  <SMILES>
COCCN1CC[C@H]2C[C@H](C(=O)Nc3cccnc3)O[C@@H]2C1

$$$$
SWF001682
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4071    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  1  0  0  0
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 13 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
  8  9  1  0  0  0  0
 15 17  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001682

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)COc1ccccc1)C2

$$$$
SWF001683
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   11.3566   -1.3361   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6282    1.2478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0180    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7680    3.9171   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 12  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001683

>  <SMILES>
O=C(Cc1ccco1)N1CCC2(CC1)CC(OCC1CC1)CO2

$$$$
SWF001684
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   10.3923   -2.2500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6423   -3.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1423   -3.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  6  0  0  0
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 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 22 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001684

>  <SMILES>
CN(C)C(=O)C1Cn2ccnc2C2(CCN(S(=O)(=O)c3ccc(F)cc3)CC2)O1

$$$$
SWF001685
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001685

>  <SMILES>
c1coc(CN2CCO[C@@H]3CN(C4CCOCC4)C[C@@H]3C2)c1

$$$$
SWF001686
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001686

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CCC[C@]2(CCN(Cc3ccoc3)C2)O1

$$$$
SWF001687
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 10 11  2  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001687

>  <SMILES>
Cc1ccc(CN2CC[C@@]3(C[C@H](NC(=O)c4ccco4)CCO3)C2)cc1

$$$$
SWF001688
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 18 21  2  0  0  0  0
 21 22  1  0  0  0  0
  7 10  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001688

>  <SMILES>
Cc1ccc2c(n1)N(C)CCN(C(=O)c1ccncc1F)C2

$$$$
SWF001689
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.2684    0.9463   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  1  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 13  1  6  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001689

>  <SMILES>
CN(C)C(=O)C[C@@H]1OC[C@H]2CN(Cc3ccccc3Cl)CC[C@H]21

$$$$
SWF001690
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1792   -5.2521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001690

>  <SMILES>
Cc1cccc(COCC2CC3(CCN(C(=O)N(C)C)CC3)CO2)n1

$$$$
SWF001691
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001691

>  <SMILES>
O=S(=O)(NC[C@H]1CCC[C@]2(CCN(c3ncccn3)C2)O1)C1CC1

$$$$
SWF001692
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001692

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccc(OC)cc3)CC2)CN1C

$$$$
SWF001693
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001693

>  <SMILES>
CCN1Cc2c(C(=O)Nc3cccnc3C)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF001694
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001694

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@@H]2CCN(C3CCC3)C[C@H]2O1

$$$$
SWF001695
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 14 15  2  0  0  0  0
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M  END
>  <HTSID>
SWF001695

>  <SMILES>
O=C(Cc1ccco1)N1CC[C@]2(CCC[C@H](CN3CCOCC3)O2)C1

$$$$
SWF001696
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 18 20  1  0  0  0  0
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 13 14  1  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001696

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cscn2)[C@@H]2CN(Cc3ccco3)C[C@@H]21

$$$$
SWF001697
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 11 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001697

>  <SMILES>
O=C(c1ccncc1)N1CC2(C1)OCCC2COc1ccccn1

$$$$
SWF001698
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 16  1  0  0  0  0
 14 17  1  6  0  0  0
 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF001698

>  <SMILES>
CO[C@@H]1CCN(C(=O)N2CCCC2)[C@@H]2CN(Cc3ccco3)C[C@@H]21

$$$$
SWF001699
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001699

>  <SMILES>
O=C(C1CCC1)N1Cc2ccccc2C2(CCN(c3cnccn3)CC2)C1

$$$$
SWF001700
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001700

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccsc1)C2)c1ccco1

$$$$
SWF001701
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0725    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0772   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4949   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2804    2.1720   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0241   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2151   -6.7909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4061   -6.2031   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5450   -6.5122   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  7  9  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001701

>  <SMILES>
COCC1CC2(CCN(Cc3cnn(C)c3)CC2)CN1Cc1ccccn1

$$$$
SWF001702
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1869   -5.4470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9392    2.4955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001702

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccc(C)cn3)CC2)CN1C

$$$$
SWF001703
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9417    2.8178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5404    1.7997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3539    3.6268   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9526    2.6087   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716    4.3313   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  1  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001703

>  <SMILES>
CN1CCN(C[C@H]2CCC[C@]3(CCN(Cc4cnn(C)c4)C3)O2)CC1

$$$$
SWF001704
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0926    2.4343   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6913    3.4524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6804    3.2433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2791    4.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2736    4.1569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8724    5.1749   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3724    6.0410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8942    5.3829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7033    6.7841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  1  0  0  0
 17 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  8  9  1  0  0  0  0
 16 20  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001704

>  <SMILES>
Cc1ccccc1OCC(=O)N1CC[C@@]2(C[C@@H](N3CCCC3)CCO2)C1

$$$$
SWF001705
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3615    3.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    5.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2275    4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001705

>  <SMILES>
COc1ccccc1CN1CC[C@]2(C[C@H](OCC3CC3)CO2)C1

$$$$
SWF001706
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9684   -1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.2139   -1.2988   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4676   -3.7125   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6811   -1.6106   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8379   -3.1024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.1369   -3.8524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001706

>  <SMILES>
Cc1noc(C2CCC3(CCN(Cc4nccs4)CC3)O2)n1

$$$$
SWF001707
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0570    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001707

>  <SMILES>
Cc1noc([C@H]2CO[C@@H]3CN(C(=O)c4ccc5c(c4)OCO5)C[C@H]23)n1

$$$$
SWF001708
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.0782    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5782   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001708

>  <SMILES>
c1ccc(CO[C@@H]2CO[C@@]3(CCN(Cc4ccoc4)C3)C2)nc1

$$$$
SWF001709
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5314   -5.9437   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001709

>  <SMILES>
c1cc(CN2CC[C@]3(C[C@H](OCC4CCOCC4)CO3)C2)co1

$$$$
SWF001710
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.6038    4.2416   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5249    3.6003   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 14 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001710

>  <SMILES>
CCN1CC2(CC1=O)CN(Cc1cccnc1)CCN(C(=O)C(C)C)C2

$$$$
SWF001711
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.6181   -1.3318   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3091   -2.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1181   -2.8707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8782   -2.5919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001711

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)c3ccc(C)s3)CC2)N1C

$$$$
SWF001712
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3581    1.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2215    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7215    2.4820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1996    1.8239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3906    3.2251   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3041    2.8184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001712

>  <SMILES>
Cn1cccc1C(=O)NC[C@@H]1CCC[C@]2(CCN(C3CCCC3)C2)O1

$$$$
SWF001713
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.8255   -2.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3287    0.2158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  5  7  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001713

>  <SMILES>
CCOCC1C(=O)N(CC)CC12CCN(C(=O)c1ccc(C)cn1)CC2

$$$$
SWF001714
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001714

>  <SMILES>
Cc1cnc(N[C@@H]2CCO[C@]3(CCN(S(=O)(=O)N(C)C)C3)C2)nc1

$$$$
SWF001715
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.7543    2.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001715

>  <SMILES>
O=C(c1cccs1)N1C[C@@H]2COC[C@]2(COCc2ccncc2)C1

$$$$
SWF001716
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  5 10  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001716

>  <SMILES>
c1ccc(COCC23CCCOC2CCN(Cc2ccoc2)C3)nc1

$$$$
SWF001717
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.9831   -2.3928   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1014   -3.6063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001717

>  <SMILES>
COCC1CC2(CCN(Cc3cccnc3OC)CC2)CN1C

$$$$
SWF001718
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.0091    4.8646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0145    4.9691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2170    3.8865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6078    4.0556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3509    3.3865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6297    3.8477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 11  1  6  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001718

>  <SMILES>
O=C(C[C@H]1OC[C@H]2CN(Cc3ccsc3)CC[C@H]21)N1CCCC1

$$$$
SWF001719
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.8737   -1.5454   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.5647   -2.4965   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5866   -2.7044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2339   -3.2396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2776   -3.6554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9174   -1.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9248   -4.1907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9393   -2.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5380   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
 10  9  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001719

>  <SMILES>
O=C(NCC1CC1)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccccc2F)O1

$$$$
SWF001720
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3548    2.6341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5303    1.0160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001720

>  <SMILES>
Cc1cncc(C(=O)N2CC[C@]3(CCC[C@H](CN4CCCC4)O3)C2)c1

$$$$
SWF001721
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.9280    2.0818   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001721

>  <SMILES>
c1cc(CN2CCC[C@]3(C[C@@H](OCC4CCOCC4)CO3)C2)cs1

$$$$
SWF001722
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  1  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001722

>  <SMILES>
O=C(N[C@@H]1CCO[C@]2(CCN(Cc3ccccn3)C2)C1)c1ccccc1

$$$$
SWF001723
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1203    1.1591   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7443   -0.6445   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3424   -0.6445   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0434   -5.8945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001723

>  <SMILES>
COc1cc(N2CC[C@@H]3[C@@H]2CCN3Cc2cccs2)ncn1

$$$$
SWF001724
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.4650   -1.7340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7958   -2.4771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1341   -0.9908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7218   -1.0649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2081   -2.4031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8263   -0.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7437   -1.2728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001724

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2[C@@H](CC(=O)NCc3ccco3)CO[C@@H]2C1

$$$$
SWF001725
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703    1.6399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568    3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740    2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240    4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8469   -3.3565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0875   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3834   -4.7831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0838   -5.0950   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5474   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5437   -7.6363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0072   -9.0628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9235   -7.3244   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0035  -10.1776   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9272   -8.4391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4637   -9.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001725

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3ccccc3)CC[C@H]21)N1CCCO1

$$$$
SWF001726
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9511    1.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9511    2.8090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5388    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    3.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    5.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 12 18  2  0  0  0  0
 12 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 13 18  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001726

>  <SMILES>
Cc1cccc(C(=O)N2C[C@@H](c3nc(C)no3)C[C@H]3OCC[C@H]32)n1

$$$$
SWF001727
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2444    0.6499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7226    1.3080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.9200    3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1065    4.9610   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 16  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001727

>  <SMILES>
CN1C[C@@H](COCc2cccnc2)[C@]2(CCN(Cc3ccccn3)C2)C1

$$$$
SWF001728
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2135   -1.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2135   -1.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 16  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001728

>  <SMILES>
O=C(N1CCOCC1)[C@@]12CCO[C@@H]1CCN(CC1CCC1)C2

$$$$
SWF001729
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001729

>  <SMILES>
CN1C(COCc2cccnc2)CCC12CCN(c1ncccn1)CC2

$$$$
SWF001730
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.9090    1.9456   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001730

>  <SMILES>
O=C(C[C@H]1C[C@H]2CN(Cc3nccs3)C[C@H]2O1)N1CCOCC1

$$$$
SWF001731
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001731

>  <SMILES>
Cn1cc(C(=O)N[C@@H]2CCO[C@]3(CCN(Cc4ccoc4)C3)C2)cn1

$$$$
SWF001732
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 21 23  2  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001732

>  <SMILES>
O=C(c1ccoc1)N1C[C@@H]2COC[C@]2(CNc2ccccn2)C1

$$$$
SWF001733
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.0524   -6.6646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6821   -7.2747   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4227   -6.0545   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6625   -8.0349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001733

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)CC(Oc1ccccn1)CO2

$$$$
SWF001734
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  2  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001734

>  <SMILES>
O=C1CCCN1Cc1nnc2n1CCN(Cc1ccoc1)C2

$$$$
SWF001735
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 23 25  3  0  0  0  0
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 11 12  1  0  0  0  0
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 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001735

>  <SMILES>
N#Cc1cccc(NC2COC3(CCN(C(=O)c4ccoc4)C3)C2)n1

$$$$
SWF001736
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3792   -5.8331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001736

>  <SMILES>
c1cc(CN2CC[C@@]3(C[C@H](N4CCCC4)CCO3)C2)cs1

$$$$
SWF001737
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -0.8090    4.0878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8090    4.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0878    5.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001737

>  <SMILES>
COCC1COCCC12CCN(Cc1nc(C)cs1)CC2

$$$$
SWF001738
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1758   -3.3010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4848   -2.3499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -3.8888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7938   -3.3010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001738

>  <SMILES>
Cc1ccccc1CN1CC[C@@]2(C[C@H](N3CCCC3)CCO2)C1

$$$$
SWF001739
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001739

>  <SMILES>
COc1ccccc1CN1CC[C@@]2(C[C@H](N(C)C)CCO2)C1

$$$$
SWF001740
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8198   -3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001740

>  <SMILES>
Cn1cc(C(=O)N[C@H]2CCO[C@]3(CCN(Cc4ccccn4)C3)C2)cn1

$$$$
SWF001741
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6804   -4.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6859   -4.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001741

>  <SMILES>
O=C(c1ccccc1)N1CC[C@@]2(C[C@H](Nc3ncccn3)CCO2)C1

$$$$
SWF001742
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.4955    0.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    2.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001742

>  <SMILES>
O=C(CC1=CCCCC1)N1CC[C@]2(C[C@H](OCC3CC3)CO2)C1

$$$$
SWF001743
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001743

>  <SMILES>
C1CCN(CCN2CCO[C@H]3[C@@H](OCC4CC4)CC[C@@H]32)CC1

$$$$
SWF001744
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.7418   -4.5556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001744

>  <SMILES>
Cc1cccc(C(=O)N2CCn3c(Cn4cncn4)cnc3C2)n1

$$$$
SWF001745
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.2107   -6.8334   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7435   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF001745

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(C(=O)c1ccoc1)C2

$$$$
SWF001746
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001746

>  <SMILES>
c1ccc(CN2CC3CN(Cc4nccs4)CC3C2)nc1

$$$$
SWF001747
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.1801   -2.6333   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
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  7 10  1  0  0  0  0
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 19 22  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001747

>  <SMILES>
c1cnc(N2CCO[C@@H]3CN(Cc4ccco4)C[C@@H]3C2)nc1

$$$$
SWF001748
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  7  8  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001748

>  <SMILES>
COCC1CN(C(C)=O)CC12CCN(Cc1cc(C)cc(C)c1)CC2

$$$$
SWF001749
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.1097    0.9067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.2788   -0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001749

>  <SMILES>
c1coc(CN2CCC3(CC2)CN(Cc2nccs2)CCO3)c1

$$$$
SWF001750
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.4810   -4.3060   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001750

>  <SMILES>
O=C(c1cscn1)N1CCC2(CCN(Cc3ccco3)CC2)C1

$$$$
SWF001751
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7978   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001751

>  <SMILES>
Cc1noc(C[C@@H]2CO[C@@H]3CN(C(=O)c4ccnnc4)C[C@H]23)n1

$$$$
SWF001752
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 15  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 11  1  0  0  0  0
 12 14  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001752

>  <SMILES>
O=C(CC1CC2(CCN(Cc3ccccn3)CC2)c2ccccc21)NCC1CC1

$$$$
SWF001753
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3643    3.2954   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001753

>  <SMILES>
COCC1CCS(=O)(=O)C12CN(S(=O)(=O)c1ccccc1)C2

$$$$
SWF001754
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6066   -2.6351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8238   -1.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6103   -3.7498   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001754

>  <SMILES>
CN(Cc1ccco1)C1COC2(CCN(C(=O)c3ccoc3)CC2)C1

$$$$
SWF001755
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5468   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 12 15  1  0  0  0  0
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 16 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  9  1  1  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001755

>  <SMILES>
O=C(CCO)N1C[C@H]2CCN(Cc3cccnc3)C(=O)[C@@H]2C1

$$$$
SWF001756
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207   -2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162   -1.4013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  6  0  0  0
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 15 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001756

>  <SMILES>
O=C(C1=CCCC1)N1CC[C@H]2OCC[C@@]2(COc2cccnc2)C1

$$$$
SWF001757
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  6  0  0  0
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 22 24  2  0  0  0  0
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 14 15  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001757

>  <SMILES>
O=C(Cc1ccco1)N1CC[C@]2(C[C@H](Oc3ccccn3)CO2)C1

$$$$
SWF001758
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.0782    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
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  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001758

>  <SMILES>
c1cc(CO[C@@H]2CO[C@@]3(CCN(Cc4ccsc4)C3)C2)ccn1

$$$$
SWF001759
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 19 23  1  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001759

>  <SMILES>
CCN1C(=O)CCCC12CCCN(C(=O)c1ccccc1F)C2

$$$$
SWF001760
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 21 24  2  0  0  0  0
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 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001760

>  <SMILES>
COc1ncccc1CN1C[C@@H]2C[C@H](CC(=O)N3CCC3)O[C@@H]2C1

$$$$
SWF001761
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9407   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5340   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1218   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8703   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1163   -2.1435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001761

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CN(Cc3ccncc3)C2)C1

$$$$
SWF001762
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.5686    0.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
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 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001762

>  <SMILES>
Cn1cc(CN2CCCC3(CC(n4ccnc4)CO3)C2)cn1

$$$$
SWF001763
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -1.2990    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001763

>  <SMILES>
COCC1COCCC12CCN(C(=O)c1cnn(C)c1)CC2

$$$$
SWF001764
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001764

>  <SMILES>
CO[C@@H]1CCN(Cc2nccs2)[C@@H]2CN(CC3CC3)C[C@@H]21

$$$$
SWF001765
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.7788    3.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001765

>  <SMILES>
CCOCC1COCCC12CCN(C(=O)c1cscn1)CC2

$$$$
SWF001766
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6759    0.9432   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6654   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4191    1.6123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2851    1.1123   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3146    2.6068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 19  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001766

>  <SMILES>
Cc1nnc([C@]23COC[C@H]2CN(C(=O)Cc2ccsc2)C3)o1

$$$$
SWF001767
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1147   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5046   -4.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0046   -7.2221   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7546   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001767

>  <SMILES>
CO[C@H]1CCN(Cc2cc(C)on2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF001768
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   12.6556    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3171   -3.3681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4190   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4518   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1988   -4.5816   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.3007   -3.0545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.6905   -4.4248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2964    2.6429   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001768

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)c3cccnc3)CC2)N1CC1CC1

$$$$
SWF001769
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3425   -2.0159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206   -1.8080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 23 26  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001769

>  <SMILES>
O=C(c1ccccn1)N1CC[C@]2(C1)C(=O)NC[C@@H]2COc1ccccn1

$$$$
SWF001770
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    3.4345    1.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3005    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9345    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9400    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001770

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@]2(Cc2nnc(C3CC3)o2)C1

$$$$
SWF001771
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.2211    4.8308   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8476    5.8875   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3558    5.7307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4742    6.9442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7457    4.3604   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9824    6.7874   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2540    4.2036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  6  1  0  0  0  0
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  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001771

>  <SMILES>
O=C(Nc1cccnc1)C1CCC2(CCN(C(=O)Cc3ccccc3)CC2)O1

$$$$
SWF001772
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9538    5.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4538    6.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4538    7.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001772

>  <SMILES>
Cc1noc(C2CCC3(CCN(C(=O)c4cnn(C)c4)CC3)O2)n1

$$$$
SWF001773
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6470    0.6910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491    0.6910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6470    2.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491    2.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0592    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1369    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6369    0.6340   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6369    2.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1369    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1369    3.2321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6369    4.0981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  1  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001773

>  <SMILES>
COc1cc(N2C[C@@H]3COC[C@]3(C(=O)NCc3ccco3)C2)ncn1

$$$$
SWF001774
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6456   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3147   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8851    0.9774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6941    2.3786   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7987    1.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  6  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001774

>  <SMILES>
CN(C)C(=O)NC[C@@H]1CCC[C@]2(CCN(Cc3ccoc3)C2)O1

$$$$
SWF001775
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    2.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321    0.6340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1525    1.4680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001775

>  <SMILES>
COCC1c2nnn(CC3CC3)c2CCN1S(C)(=O)=O

$$$$
SWF001776
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.0227    8.4411   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7727    7.1421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0264    9.5559   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2399    7.4540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1626    5.7718   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3967    8.9458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0442    4.5583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5807    3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0078    3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001776

>  <SMILES>
CN(C)C(=O)NC[C@H]1CCC[C@]2(CCN(Cc3cccs3)C2)O1

$$$$
SWF001777
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6456   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.2050    1.9296   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001777

>  <SMILES>
CN(C)C(=O)N[C@@H]1CCO[C@]2(CCN(Cc3ccncc3)C2)C1

$$$$
SWF001778
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001778

>  <SMILES>
O=C(N[C@H]1CCO[C@]2(CCN(Cc3ccccn3)C2)C1)c1ccccc1

$$$$
SWF001779
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  6  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001779

>  <SMILES>
Clc1cncc(OC[C@H]2CO[C@@H]3CN(Cc4ccc[nH]4)C[C@H]23)c1

$$$$
SWF001780
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  5  7  2  0  0  0  0
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  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001780

>  <SMILES>
Cc1noc([C@H]2C[C@H]3CN(C(=O)/C=C/c4cccs4)CC[C@H]3O2)n1

$$$$
SWF001781
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7270    8.3535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6123    7.3498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 13  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001781

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(CC3CC3)CC[C@H]21)NCc1cccnc1

$$$$
SWF001782
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8367    2.4790   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2652    4.0061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8404    3.5937   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6165    5.2196   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7570    4.1629   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2107    2.9836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0064    6.5899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0955    8.1170   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2138    9.3305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  6  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 21 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001782

>  <SMILES>
COC[C@H]1CN(C)C[C@@]12CCN(C(=O)c1ccc3ccccc3c1)C2

$$$$
SWF001783
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001783

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1CC[C@@H]2[C@@H](CCN2CC2CC2)O1

$$$$
SWF001784
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7850    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 21 26  1  0  0  0  0
 13 16  1  0  0  0  0
 18 22  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001784

>  <SMILES>
CC(=O)N1CCN(S(=O)(=O)Cc2ccccc2)CC2(CC(=O)N(C)C2)C1

$$$$
SWF001785
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001785

>  <SMILES>
O=C(c1ccncn1)N1CCO[C@H]2[C@@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF001786
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   14.4272   -1.9978   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   12.4637   -3.4243   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6772   -4.3060   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.6772   -5.8060   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001786

>  <SMILES>
CCOCC1CCC2(CCN(Cc3nc(C)cs3)CC2)N1C

$$$$
SWF001787
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   12.1916    3.5388   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.3256    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4596    3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3256    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5936    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4596    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5936    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8140    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6230    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF001787

>  <SMILES>
COCCNC(=O)C[C@H]1C[C@H]2CN(c3ncc(F)cn3)C[C@H]2O1

$$$$
SWF001788
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9378    4.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3081    3.4465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001788

>  <SMILES>
COc1ncccc1CN1CC[C@@]2(C[C@@H](N3CCCC3=O)CCO2)C1

$$$$
SWF001789
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  1  0  0  0
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 11 13  1  0  0  0  0
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 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001789

>  <SMILES>
c1ccc(N[C@@H]2CCO[C@]3(CCN(c4ncccn4)C3)C2)nc1

$$$$
SWF001790
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001790

>  <SMILES>
O=C1NC[C@@H](COc2cccnc2)[C@]12CCN(Cc1cccnc1)C2

$$$$
SWF001791
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.9606   -2.6745   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001791

>  <SMILES>
Cc1ncsc1CN1CC[C@H]2OCC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF001792
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0181    0.9013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 21 23  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001792

>  <SMILES>
CS(=O)(=O)NCC[C@@]12CCO[C@@H]1CCN(Cc1cccnc1)C2

$$$$
SWF001793
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001793

>  <SMILES>
O=C(c1ncccn1)N1C[C@@H]2COC[C@]2(COCc2cccnc2)C1

$$$$
SWF001794
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 21 26  1  0  0  0  0
 23 27  2  0  0  0  0
 10 11  2  0  0  0  0
 16 19  1  0  0  0  0
 18 22  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001794

>  <SMILES>
CC(C)n1c2ccccc2c2c1cc(C(=O)NCCO)n2-c1ncccn1

$$$$
SWF001795
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 20 24  2  0  0  0  0
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 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 21  1  0  0  0  0
 22 23  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001795

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CC1)OC(C(=O)N1CCCC1)Cn1ccnc12

$$$$
SWF001796
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  6  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001796

>  <SMILES>
Clc1cncc(OC[C@H]2CO[C@@H]3CN(C4CCC4)C[C@H]23)c1

$$$$
SWF001797
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -7.3278    3.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001797

>  <SMILES>
O=C(C1CCSCC1)N1CC[C@]2(CCC[C@H](CN3CCCC3)O2)C1

$$$$
SWF001798
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    1.8605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8717    2.6037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6638    3.5818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  6  1  0  0  0  0
  7  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001798

>  <SMILES>
c1ccc(NC[C@@H]2CO[C@@H]3CN(Cc4cccnc4)C[C@H]23)nc1

$$$$
SWF001799
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3304    0.4282   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3841    0.1050   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1732   -0.1102   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2777   -1.1047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5725   -1.6871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5653   -1.8065   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3835   -2.3325   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001799

>  <SMILES>
COCCN1CCC2(COCCN(Cc3cnn(C)c3)C2)C1

$$$$
SWF001800
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2258   -3.6684   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5645   -3.6684   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8182   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4283    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF001800

>  <SMILES>
Cc1noc(C[C@@H]2C[C@H]3CN(S(=O)(=O)C4CC4)C[C@H]3O2)n1

$$$$
SWF001801
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.7054    1.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001801

>  <SMILES>
O=C(c1ccsc1)N1C[C@@H]2COC[C@]2(COCC2CCC2)C1

$$$$
SWF001802
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.2192   -3.0722   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4271   -2.0941   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2681   -3.3813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6840   -1.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5250   -2.7121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7329   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9898   -1.0649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0943   -0.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0116   -1.2728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001802

>  <SMILES>
c1cc(OC[C@@H]2CO[C@@H]3CN(C4CCOCC4)C[C@H]23)ccn1

$$$$
SWF001803
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
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 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
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  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001803

>  <SMILES>
c1ccc(CN2CCOC3(CCN(Cc4ccoc4)CC3)C2)cc1

$$$$
SWF001804
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1935   -4.8386   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1070   -4.4318   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5243   -4.0954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0243   -3.2294   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5298   -4.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5377   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6990   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001804

>  <SMILES>
Cc1cc(CN2CC3(C2)OCCC3CCOCc2ccccn2)no1

$$$$
SWF001805
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  2  0  0  0  0
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 24 26  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF001805

>  <SMILES>
COCC(=O)NC[C@]12COC[C@H]1CN(Cc1ccc3ccccc3n1)C2

$$$$
SWF001806
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   11.8635    2.9184   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8672    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6500    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1172    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF001806

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CN(C(=O)c3cccs3)C[C@@H]2N1C(C)C

$$$$
SWF001807
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4028   -1.5173   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3038   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2928   -0.4183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001807

>  <SMILES>
CS(=O)(=O)N1CCC2(CCN(Cc3ccccn3)C2=O)CC1

$$$$
SWF001808
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    1.8605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8717    2.6037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0186    3.5307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  6  1  0  0  0  0
  7  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001808

>  <SMILES>
c1cncc(CN2C[C@@H]3[C@@H](COc4ccncc4)CO[C@@H]3C2)c1

$$$$
SWF001809
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.1152   -0.2873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4461   -1.0305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7551   -1.9815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0860   -2.7247   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7332   -2.1894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8206   -1.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3950   -3.6757   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0422   -3.1405   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  3  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF001809

>  <SMILES>
CNC(=O)c1cnc2n1CCN(C(=O)c1cccc(C#N)c1)C2

$$$$
SWF001810
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7050    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8861   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5771   -2.2829   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8861   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1951   -2.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001810

>  <SMILES>
O=C(c1ccco1)N1CCC2(CCN(Cc3cccnc3)C2)CC1

$$$$
SWF001811
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4385    4.4927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
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  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001811

>  <SMILES>
Cn1cc(CN2CC[C@]3(C[C@@H](OCc4ccncc4)CO3)C2)cn1

$$$$
SWF001812
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5506   -3.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3596   -4.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8814   -3.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001812

>  <SMILES>
Cn1nnc2c1C(COCc1ccccn1)CN(C(=O)c1ccco1)C2

$$$$
SWF001813
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
   11.1761    2.1085   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7125    0.6819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7162   -0.4328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2416    1.4848   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2527   -1.8594   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.2564   -2.9741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  6  0  0  0
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 18 22  1  0  0  0  0
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 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
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 24 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001813

>  <SMILES>
CN1C[C@H]2C3(CCN(C(=O)c4cnccn4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF001814
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3839    5.1680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749    5.7558   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001814

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(C(=O)c2ccoc2)C3)n1

$$$$
SWF001815
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3917    0.5649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1348    1.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0859    0.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2938   -0.0532   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7801    1.2851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2449   -0.3622   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3643    3.2414   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9880    0.3069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  6  0  0  0
 14 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001815

>  <SMILES>
COc1ccccc1CN1C[C@@H]2[C@@H](C(=O)N3CCCO3)CO[C@@H]2C1

$$$$
SWF001816
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1141   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4814   -5.2368   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8265   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5174   -4.9708   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5262   -6.2358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9665   -5.8054   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5900   -6.5872   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001816

>  <SMILES>
O=C(N1CCCC1)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF001817
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.3923    5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001817

>  <SMILES>
CCN(C)C1C=CC2(CC1)CCN(C(=O)c1cccnc1)CC2

$$$$
SWF001818
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1665    1.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0326    0.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3005    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001818

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@]2(CNC(=O)c2ccccc2)C1

$$$$
SWF001819
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001819

>  <SMILES>
Cc1cccc(COC[C@]23COC[C@H]2CN(c2ncccn2)C3)n1

$$$$
SWF001820
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001820

>  <SMILES>
Cc1cc(C(=O)N2C[C@@H]3COC[C@]3(CNS(C)(=O)=O)C2)no1

$$$$
SWF001821
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9089    0.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF001821

>  <SMILES>
CC(=O)N1Cc2ncn(CC3CC3)c2C(COCc2cccnc2)C1

$$$$
SWF001822
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001822

>  <SMILES>
COCC(=O)NC[C@@H]1CCC[C@]2(CCN(c3ncccn3)C2)O1

$$$$
SWF001823
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001823

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccoc1)C2)c1ccccc1

$$$$
SWF001824
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8829    6.1486   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001824

>  <SMILES>
Fc1cnc(N2CC3(CC(OCc4ccccn4)CS3)C2)nc1

$$$$
SWF001825
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001825

>  <SMILES>
O=C(c1cocn1)N1C[C@H]2CCC[C@@]2(COCc2cccnc2)C1

$$$$
SWF001826
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2709   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2709   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7709   -1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001826

>  <SMILES>
CCn1cc2c(n1)CN(C(=O)CS(C)(=O)=O)CC2COC

$$$$
SWF001827
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  9 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001827

>  <SMILES>
CO[C@@H]1CCN(C(=O)CN(C)C)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF001828
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6342   -2.8025   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7207   -2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6162   -1.4013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9117   -2.9836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026   -0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4252   -0.8135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9981   -2.5768   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0162   -3.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206    0.1810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1891   -3.1646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2072   -4.5659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2936   -4.1591   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2756   -2.7579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    1.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4846   -4.7469   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  6  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001828

>  <SMILES>
COC[C@@]12CCO[C@@H]1CCN(C(=O)c1ccc(C)c(C)c1)C2

$$$$
SWF001829
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    8.9280    2.0818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5667    0.4181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001829

>  <SMILES>
Cc1cc(CN2CCC[C@]3(C[C@@H](OCc4ccncc4)CO3)C2)no1

$$$$
SWF001830
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    9.5263    2.7749   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.7398    1.8932   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.8966    3.3850   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9162    4.1452   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1877    6.7290   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8143    5.6723   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  1  1  0  0  0
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 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  1  0  0  0
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 22 24  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001830

>  <SMILES>
O=S(=O)(c1cccnc1)N1CCC[C@]2(C[C@@H](OCC3CC3)CO2)C1

$$$$
SWF001831
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
  5  6  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001831

>  <SMILES>
CCN1CC2(CC1=O)CN(C(C)=O)CCN(C(=O)c1cccs1)C2

$$$$
SWF001832
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7402   -2.4999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0765   -1.8613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001832

>  <SMILES>
Cn1cccc1C(=O)N1CCC2(CC1)CC(OCc1ccncc1)CO2

$$$$
SWF001833
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.2350   -1.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001833

>  <SMILES>
COCCN1CC[C@H]2C[C@@H](C(=O)Nc3cccnc3)O[C@H]2C1

$$$$
SWF001834
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.9998    3.4721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7498    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5080    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1315    0.9595   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1315    3.3866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5581    1.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5581    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001834

>  <SMILES>
Cc1cc(C(=O)N2C[C@H]3CCC[C@@]3(COCc3ccccn3)C2)c(C)o1

$$$$
SWF001835
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.3923   -5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4239   -4.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4202   -5.7546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1120   -3.1727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5070    0.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8969    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4051    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4014    2.5819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  6  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001835

>  <SMILES>
Cc1occc1C(=O)N1Cc2nnn(C)c2C(COCCN(C)C)C1

$$$$
SWF001836
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.3433   -5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8433   -3.2010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001836

>  <SMILES>
CS(=O)(=O)N1CCC2(CCN(Cc3nccs3)CC2)CC1

$$$$
SWF001837
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1277   -2.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
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 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  5  1  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001837

>  <SMILES>
c1ccc(COC[C@]23COC[C@H]2CN(Cc2cccnc2)C3)nc1

$$$$
SWF001838
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  6  0  0  0
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  9 13  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001838

>  <SMILES>
O=C(c1cocn1)N1C[C@@H]2COC[C@]2(COCc2ccccn2)C1

$$$$
SWF001839
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.1731    2.3366   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2905    1.3305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9778   -0.1402   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6043   -0.7518   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9839   -1.2576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001839

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)c2ccncc2)[C@H]1Cc1ccncc1

$$$$
SWF001840
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    1.2990   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF001840

>  <SMILES>
COc1ncccc1CN1CC[C@@H](N(C)C)[C@@H]1Cc1ccncc1

$$$$
SWF001841
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 22 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001841

>  <SMILES>
Cc1cccc(CN2C(=O)CCC23CCN(Cc2cccs2)CC3)n1

$$$$
SWF001842
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.6721   -1.2275   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3335   -5.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4354   -3.6546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2152   -6.3952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3171   -4.8681   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001842

>  <SMILES>
Cn1ccnc1CN1CCC2(CC1)CCN(C(=O)c1cnccn1)C2

$$$$
SWF001843
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5358    0.9115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001843

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF001844
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5373    3.9955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001844

>  <SMILES>
CCN1C(=O)CC(c2cnn(C)c2)C12CCN(CCO)CC2

$$$$
SWF001845
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3530    3.0362   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001845

>  <SMILES>
O=C(c1cnccn1)N1CCOC2CCC1C2OCC1CC1

$$$$
SWF001846
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001846

>  <SMILES>
O=C1C[C@@H]2[C@H](CCN2Cc2ccccn2)N1Cc1ccncc1

$$$$
SWF001847
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9283    5.1618   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0238    4.7268   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001847

>  <SMILES>
CCOC1C2CCC1N(C(=O)c1ccc(F)c(OC)c1)CCO2

$$$$
SWF001848
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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 13 16  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001848

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3[C@H]2CCN3Cc2ccc(C)o2)cn1

$$$$
SWF001849
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 25 28  1  0  0  0  0
 11 14  1  0  0  0  0
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 26 28  2  0  0  0  0
M  END
>  <HTSID>
SWF001849

>  <SMILES>
CN1CC2(CCN(C(=O)c3cccn3C)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF001850
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 11 16  2  0  0  0  0
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 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001850

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CNS(=O)(=O)c1ccccc1OC2

$$$$
SWF001851
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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   -0.1885   -4.3298   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9705   -5.6170   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9316   -4.9990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2273   -6.2861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7237   -5.9771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4669   -6.6462   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  5  7  2  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001851

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(c4ncc(C)cn4)C[C@@H]32)C(=O)N1C

$$$$
SWF001852
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.1015    0.5022   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7361   -0.4287   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4668    1.4331   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1706    0.8675   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0323    0.1369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4375    0.1874   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0959    1.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4487    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2696    2.4281   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7796   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3140    2.1333   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9706    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 10 12  1  1  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001852

>  <SMILES>
Cc1ccc(N2C[C@@H]3CN(S(C)(=O)=O)CCO[C@@H]3C2)nn1

$$$$
SWF001853
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
 10  8  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001853

>  <SMILES>
O=C(c1ccoc1)N1CC[C@H]2OCC[C@@]2(COc2ncccc2F)C1

$$$$
SWF001854
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    9.1488   -5.0486   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1707   -5.2565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5015   -4.5134   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  2  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 18 21  1  0  0  0  0
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 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  6  8  1  0  0  0  0
 11 13  2  0  0  0  0
 15 16  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001854

>  <SMILES>
COCC(=O)N1CCC2(CC1)c1ncc(-c3cccc(F)c3)n1CCN2C(C)=O

$$$$
SWF001855
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001855

>  <SMILES>
c1cnc(N2CCO[C@H]3[C@@H](OCc4cccnc4)CC[C@@H]32)nc1

$$$$
SWF001856
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.3429    3.8358   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 20 21  1  0  0  0  0
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  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001856

>  <SMILES>
O=C1N(CC2CC2)CCC12CCCN(c1ncc(F)cn1)C2

$$$$
SWF001857
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.2929   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5800    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3232   -0.1387   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9868    1.4440   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1892    0.3613   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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  6 10  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001857

>  <SMILES>
Cc1noc([C@H]2CC[C@@H]3[C@@H](CCN3Cc3ccccn3)O2)n1

$$$$
SWF001858
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.2494   -6.1970   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.3834   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3834   -4.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5173   -6.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5173   -4.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5173   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -4.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3834   -2.6970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  7  9  2  0  0  0  0
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 11 10  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001858

>  <SMILES>
CN(C)CCN1C(=O)C[C@@H]2[C@@H]1CCN2C(=O)c1cccc(Cl)c1

$$$$
SWF001859
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902    3.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3381    6.4814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7992    5.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7503    7.2904   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7992    6.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001859

>  <SMILES>
O=C(NCc1ccccn1)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccoc2)O1

$$$$
SWF001860
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9511    2.8090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5388    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116    2.5933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    5.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 12 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 11 15  1  0  0  0  0
 13 18  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001860

>  <SMILES>
Cc1noc([C@H]2C[C@H]3OCC[C@H]3N(C(=O)c3ccccn3)C2)n1

$$$$
SWF001861
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001861

>  <SMILES>
O=C(N[C@H]1CCO[C@]2(CCN(Cc3cccnc3)C2)C1)c1ccncc1

$$$$
SWF001862
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 17  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001862

>  <SMILES>
O=C(C1CCOCC1)N1CCOCC2(CCN(c3ccccn3)C2)C1

$$$$
SWF001863
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.8702   -6.2031   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1792   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3603   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 17 18  1  6  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001863

>  <SMILES>
CCOCC1CC2(CCN(C(=O)c3cscn3)CC2)CO1

$$$$
SWF001864
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001864

>  <SMILES>
CN(C)c1nc2c(cc1C(=O)O)CCN(S(=O)(=O)C1CC1)CC2

$$$$
SWF001865
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  6  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001865

>  <SMILES>
CC(C)N1c2ccc(F)cc2[C@@H]2CN(C(=O)c3ccco3)CC[C@@H]21

$$$$
SWF001866
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    7.6211    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 10 15  1  0  0  0  0
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 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 14  1  0  0  0  0
 17 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF001866

>  <SMILES>
COCCN1CC[C@H]2O[C@@H](C(=O)N(C)Cc3ccccn3)CC[C@H]21

$$$$
SWF001867
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 10 12  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001867

>  <SMILES>
O=C(NC1CC1)[C@H]1C[C@@H]2CCN(Cc3ccncc3)C[C@@H]2O1

$$$$
SWF001868
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1376    6.3701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9511    8.1972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 16 17  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001868

>  <SMILES>
COc1cccc(CN2CCC3(CC2)CC(OCC2CC2)CO3)c1

$$$$
SWF001869
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
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  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001869

>  <SMILES>
O=C([C@@H]1C[C@@H]2CCN(C3CCOCC3)C[C@@H]2O1)N1CCOCC1

$$$$
SWF001870
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6316    1.7228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001870

>  <SMILES>
O=C(c1ccoc1)N1CCO[C@@H]2[C@@H](OCc3cccnc3)CC[C@@H]21

$$$$
SWF001871
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3291   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8209   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.7026   -3.0545   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0925   -4.4248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001871

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CCC(C(=O)N3CCCC3)O2)CC1

$$$$
SWF001872
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001872

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC(=O)N(c4cncnc4)C3)C2)o1

$$$$
SWF001873
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.6770   -1.2661   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634   -1.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8974   -1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12  9  1  6  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001873

>  <SMILES>
Cc1ccc(N2CC3(CCN(Cc4cccs4)C3)CC2=O)s1

$$$$
SWF001874
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 10 12  2  0  0  0  0
 19 20  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001874

>  <SMILES>
Cn1cc(-c2nnn3c2COC(CNCc2ccco2)C3)cn1

$$$$
SWF001875
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001875

>  <SMILES>
CN(C)C(=O)N1CC[C@H]2OCC[C@@]2(COc2ncccc2F)C1

$$$$
SWF001876
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.6537   -2.0932   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5492   -1.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 17 18  1  6  0  0  0
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 23 25  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001876

>  <SMILES>
CN(Cc1ccco1)C1COC2(CCN(C(=O)c3ccsc3)CC2)C1

$$$$
SWF001877
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 15  1  0  0  0  0
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 19 20  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001877

>  <SMILES>
Cc1nnc([C@@]23CCO[C@@H]2CCN(C(=O)c2occc2C)C3)o1

$$$$
SWF001878
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.2608   -4.5229   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001878

>  <SMILES>
Cc1cccc(CN2CCO[C@H]3CN(S(C)(=O)=O)CC[C@H]3C2=O)n1

$$$$
SWF001879
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001879

>  <SMILES>
O=C(COC[C@]12COC[C@H]1CN(c1ncccn1)C2)N1CCCC1

$$$$
SWF001880
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.0234   -3.0984   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2459   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001880

>  <SMILES>
COc1ncccc1C(=O)N1CC[C@H]2C(=O)NCCO[C@H]2C1

$$$$
SWF001881
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001881

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(c1ncccn1)C2)c1ccco1

$$$$
SWF001882
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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M  END
>  <HTSID>
SWF001882

>  <SMILES>
Cc1noc(C)c1CN1CC[C@H]2C[C@H](C(=O)N3CCCC3)O[C@@H]2C1

$$$$
SWF001883
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001883

>  <SMILES>
O=C(c1ccsc1)N1CC[C@@H](OCc2ccccn2)[C@H]2OCC[C@@H]21

$$$$
SWF001884
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001884

>  <SMILES>
O=C(NCC1CC1)[C@@H]1CCO[C@@H]2CCN(Cc3cccnc3)C[C@H]21

$$$$
SWF001885
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001885

>  <SMILES>
CN1CC2(CCN(C(=O)c3cnccn3)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF001886
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001886

>  <SMILES>
COCc1ncn2c1CN(C(=O)Nc1cccc(C)c1)CC2

$$$$
SWF001887
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF001887

>  <SMILES>
Cc1noc(C)c1C(=O)N1CC2(CC(Oc3cccnc3)CS2)C1

$$$$
SWF001888
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001888

>  <SMILES>
CC(=O)N1CCN(Cc2ccoc2)CC2(CC(=O)N(C)C2)C1

$$$$
SWF001889
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001889

>  <SMILES>
Cc1noc([C@@H]2C[C@H]3OCC[C@H]3N(Cc3ccc(C)s3)C2)n1

$$$$
SWF001890
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001890

>  <SMILES>
CN(C)C(=O)Cn1cc2c(n1)C(CNCc1cccs1)OCC2

$$$$
SWF001891
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.8790    4.3612   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001891

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(Cc3ccc(F)cc3)CC2)O1

$$$$
SWF001892
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.2929   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  7  1  0  0  0  0
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 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001892

>  <SMILES>
Cc1noc([C@H]2CC[C@@H]3[C@@H](CCN3Cc3cnn(C)c3)O2)n1

$$$$
SWF001893
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 26 28  2  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 25  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF001893

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(Cc3ccncc3)C[C@H]1CN(c1ccccn1)C2

$$$$
SWF001894
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 16 20  1  6  0  0  0
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 21 22  1  0  0  0  0
 11 15  1  0  0  0  0
 14 19  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001894

>  <SMILES>
CCO[C@H]1CC[C@H]2[C@@H]1OCCN2C(=O)c1cccnc1OC

$$$$
SWF001895
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1715    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1715    4.2135   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
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  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001895

>  <SMILES>
Cc1ccc(N2C[C@H]3OCC[C@H]3[C@H](C(=O)NCc3ccco3)C2)nn1

$$$$
SWF001896
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001896

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccco2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF001897
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.6785   -3.8914   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0094   -3.1483   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1785   -4.7574   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2173   -2.1701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0958   -3.5550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2004   -4.5495   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1684   -1.8611   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4742   -1.5010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5488   -1.8802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7546   -0.5411   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754   -1.3932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1790    0.2766   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001897

>  <SMILES>
O=C(c1cccs1)N1CCc2nnc(COc3cncnc3)n2CC1

$$$$
SWF001898
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5897   -1.4575   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9033    1.5260   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.2383   -0.1226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001898

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)CC(OCc1cccnc1)CO2

$$$$
SWF001899
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6286    2.4068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2903    0.9205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6295    4.5777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  4  1  1  0  0  0
  6  8  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  1  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001899

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CN(C(=O)c3ccco3)C[C@@H]2N1S(C)(=O)=O

$$$$
SWF001900
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3280    0.6672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9972   -0.0759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2843    1.0830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9753    0.1320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001900

>  <SMILES>
O=C(C1CCOCC1)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF001901
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.3196    5.6150   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8278    5.7718   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2177    7.1421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462    4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7259    7.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    4.5583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097    3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1158    8.6692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8443    6.0854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826    3.1317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6241    8.8260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3525    6.2422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7424    7.6125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001901

>  <SMILES>
O=C(Nc1ccccc1)C1=NOC2(CCCN(CCO)C2)C1

$$$$
SWF001902
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -4.7709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7321   -5.6369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -6.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8253   -7.4165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2266   -6.6075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5685   -8.0856   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1528   -7.6244   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4345   -7.5856   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001902

>  <SMILES>
Cc1noc(C)c1CN1CC[C@H]2C[C@@H](C(=O)Nc3cccnc3)O[C@H]2C1

$$$$
SWF001903
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.6965   -3.6313   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4740   -4.6063   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9190   -2.6564   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7216   -3.4088   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6714   -3.8539   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -4.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981   -4.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971   -2.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4746   -3.4088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001903

>  <SMILES>
CS(=O)(=O)N1CCOCC2(CN(Cc3cccnc3)CCO2)C1

$$$$
SWF001904
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.6965   -3.6313   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4740   -4.6063   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9190   -2.6564   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7216   -3.4088   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6714   -3.8539   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -4.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981   -4.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971   -2.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4746   -3.4088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001904

>  <SMILES>
CS(=O)(=O)N1CCOCC2(CN(Cc3nccs3)CCO2)C1

$$$$
SWF001905
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8255   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9590   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5413   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7615   -4.5476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3493   -3.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1628   -5.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3438   -3.8431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7506   -4.7567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001905

>  <SMILES>
CCOCC1CCC2(CCN(Cc3ccccn3)CC2)N1C

$$$$
SWF001906
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2247    0.7464   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0223    1.8291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6315    1.6600   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8883    2.3291   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001906

>  <SMILES>
O=C1CC2(CCN(Cc3ccoc3)C2)CN1c1ccc2c(c1)OCO2

$$$$
SWF001907
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4752    3.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0739    3.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5685    4.9487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0685    5.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0685    5.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5685    6.6808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5685    6.6808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 15 10  1  1  0  0  0
 13 17  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001907

>  <SMILES>
COc1ncccc1C(=O)N1CC[C@H]2C[C@H](c3ccncn3)O[C@@H]2C1

$$$$
SWF001908
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001908

>  <SMILES>
O=C(C1CC=CC1)N1CCC2(CCCN(c3ncccn3)C2)CC1

$$$$
SWF001909
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2272   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7190   -3.3681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7227   -4.4828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4690   -2.0690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0930   -3.8727   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.9362   -2.3809   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0510   -1.3772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001909

>  <SMILES>
Cn1cc(CN2CCCC3(CC(Nc4ncccn4)CO3)C2)cn1

$$$$
SWF001910
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   10.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   11.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001910

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)C3CC3)CC[C@H]2OC)cc1

$$$$
SWF001911
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3399   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409   -2.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399   -1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  1  1  6  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001911

>  <SMILES>
COc1cccc(CN2C[C@H]3CCN(C(=O)c4ccccc4)CC[C@H]3S2(=O)=O)c1

$$$$
SWF001912
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9835    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5003    1.2677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0841   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8041    0.8256   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2874    0.6020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 13  1  1  0  0  0
 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001912

>  <SMILES>
CN(C)CCN1[C@H]2CCN(c3ncccn3)CC[C@@H]2Oc2ccccc2S1(=O)=O

$$$$
SWF001913
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    8.6706   -4.1572   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.6669   -5.2719   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1341   -5.5838   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    9.8841   -2.0553   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4169   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4355    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.9380   -1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2371   -2.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001913

>  <SMILES>
O=C(COc1ccccc1)N1CC[C@@H]2CN(Cc3ccccc3)S(=O)(=O)[C@@H]2CC1

$$$$
SWF001914
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001914

>  <SMILES>
Cc1nc(COCC23CCCOC2CCN(CC2CC2)C3)cs1

$$$$
SWF001915
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 13 17  1  1  0  0  0
 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001915

>  <SMILES>
CN(C)S(=O)(=O)N1CC[C@]2(C1)C(=O)NC[C@@H]2COc1cccnc1

$$$$
SWF001916
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -5.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391   -5.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301   -6.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 15  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001916

>  <SMILES>
O=C(c1ccco1)N1CCCC2(CN(Cc3ccoc3)CCO2)C1

$$$$
SWF001917
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.5907   -1.8090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3508    0.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001917

>  <SMILES>
Cc1noc([C@H]2C[C@@H]3CCN(Cc4ccc(C)o4)C[C@H]3O2)n1

$$$$
SWF001918
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3291   -1.9978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0575    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5248    0.8980   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3075    1.8851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6816    2.3897   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3112    2.9998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001918

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC1)CCN(CC1CC1)C2=O

$$$$
SWF001919
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6456   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8147    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3147   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3092   -0.2681   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9784    0.4750   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7874   -0.9262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001919

>  <SMILES>
c1cn(C2COC3(CCCN(Cc4ccsc4)C3)C2)cn1

$$$$
SWF001920
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4836    0.6855   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7405    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6426    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9484    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8994    2.6418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1073    3.6199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3642    4.2891   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5721    5.2672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  1  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001920

>  <SMILES>
C=CCOC[C@@H]1CCC[C@@]12CN(Cc1ccncc1)CCO2

$$$$
SWF001921
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001921

>  <SMILES>
O=C(N1CCCC1)N1CCCC2(CCN(Cc3ccncc3)C2=O)C1

$$$$
SWF001922
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001922

>  <SMILES>
Cc1cccc(CN2CCC3(CCN(Cc4ccc(F)cc4)C3)C2=O)c1

$$$$
SWF001923
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    7.3515    5.9146   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1947    7.4064   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8432    6.0714   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2496    4.3875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230    3.3308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001923

>  <SMILES>
COCC1CCC2(CCN(S(=O)(=O)N(C)C)CC2)N1C

$$$$
SWF001924
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  1  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001924

>  <SMILES>
O=C(c1cccnc1)N1CCO[C@H]2[C@H](Oc3ccccn3)CC[C@@H]21

$$$$
SWF001925
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 13  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001925

>  <SMILES>
O=C(C1CC=CC1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF001926
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.0616   -2.9499   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  1  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001926

>  <SMILES>
Cc1cc(C(=O)N2CCC3(C2)CN(c2cccc(F)c2)C(=O)CN3C)no1

$$$$
SWF001927
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  6  0  0  0
 14 20  1  0  0  0  0
 15 21  2  0  0  0  0
 17 22  1  0  0  0  0
 17 23  1  0  0  0  0
 19 24  1  0  0  0  0
  9 13  1  0  0  0  0
 16 21  1  0  0  0  0
 20 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001927

>  <SMILES>
CC(C)N(C)[C@@H]1CN(C(=O)Cc2ccccn2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF001928
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9480   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3657   -3.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6747   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0567   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3287    0.2158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6345    0.5759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    1.8630   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001928

>  <SMILES>
CC(C)NC(=O)C1CN(C(=O)c2ccco2)CC12CCOCC2

$$$$
SWF001929
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5296   -1.3368   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7419   -1.5792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8293   -2.2909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8053   -2.5084   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2031   -3.4259   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5550   -1.8466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1986   -3.3311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4161   -2.3551   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF001929

>  <SMILES>
c1coc(CN2CCOC3CCC2C3OCc2ccncc2)c1

$$$$
SWF001930
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4282   -4.0388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7372   -3.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4282   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1192   -3.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001930

>  <SMILES>
C=CCN1C(=O)COC2(CCN(Cc3ccsc3)CC2)C1C

$$$$
SWF001931
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.1295    3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    0.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    0.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    0.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  1  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF001931

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)c3ccccn3)C[C@H]2N1C(C)C

$$$$
SWF001932
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.5042    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0062    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0524    0.0871   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5042   -1.5021   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5042    1.5021   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2033   -2.2531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8050   -2.2531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2033   -3.7552   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2033   -0.7510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -3.0041   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8050   -3.7552   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5042   -4.5062   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6017   -2.2531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3722   -0.1401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1570   -2.2449   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3773   -1.2563   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6263   -2.5572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001932

>  <SMILES>
CS(=O)(=O)N1CCOCC12CCN(Cc1ccoc1)CC2

$$$$
SWF001933
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5768   -4.0767   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2511    3.9627   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1363    4.9664   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7098    4.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF001933

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccncc3)CC2)CN1c1ncccn1

$$$$
SWF001934
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.5314   -5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001934

>  <SMILES>
Fc1cccc(CN2CC3CN(Cc4ccncc4)CC3C2)c1

$$$$
SWF001935
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9763   -3.4237   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF001935

>  <SMILES>
Cc1noc(C[C@H]2CO[C@@H]3CN(C(=O)c4cscn4)C[C@H]23)n1

$$$$
SWF001936
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.5072    2.7853   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001936

>  <SMILES>
O=S(=O)(NC1CCC12CCN(Cc1nccs1)CC2)c1ccccc1

$$$$
SWF001937
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4942    3.0295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0765    2.3250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3022    4.9611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2967    5.0657   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001937

>  <SMILES>
c1cc(CO[C@@H]2CO[C@@]3(CCCN(Cc4ccncc4)C3)C2)ccn1

$$$$
SWF001938
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.4423    3.0986   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9341    2.9419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9378    4.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1513    1.9547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3081    3.4465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001938

>  <SMILES>
O=C1CCCN1[C@H]1CCO[C@]2(CCN(Cc3ccccn3)C2)C1

$$$$
SWF001939
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.8790    4.3612   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8845    4.2567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2967    5.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4778    3.3431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3022    4.9611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7144    5.7702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  6  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001939

>  <SMILES>
COCC1CCC2(CCN(C(=O)c3ccc(F)cc3C)CC2)N1C

$$$$
SWF001940
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7734   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3176   -0.1151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2687    0.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4766    1.1720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0118   -0.4752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4276    1.4811   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9629   -0.1662   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1708    0.8119   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001940

>  <SMILES>
COCC(=O)N1CCC2(CCC(=O)N2Cc2cccnc2)CC1

$$$$
SWF001941
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    2.7749   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0263    2.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0628    4.2015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9080    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4898    4.2015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2763    5.0831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001941

>  <SMILES>
CN(C)S(=O)(=O)N1CC[C@@]2(C[C@@H](N3CCCC3=O)CCO2)C1

$$$$
SWF001942
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0692    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7261    5.1253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5533    6.0606   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6206    7.5591   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1074    5.6615   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2163    8.0861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2810    6.9134   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001942

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF001943
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   14.2894    3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  2  0  0  0  0
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  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
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 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF001943

>  <SMILES>
O=C(CO)N1CCOC2(CCCN(c3ncc(F)cn3)C2)C1

$$$$
SWF001944
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001944

>  <SMILES>
COCC12CCCOC1CCN(C(=O)c1ccccc1C)C2

$$$$
SWF001945
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    0.0681    1.5068   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0463    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4319    2.3729   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1508    2.7093   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4836    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF001945

>  <SMILES>
C=CCOC[C@@H]1CCC[C@@]12CN(Cc1cccs1)CCO2

$$$$
SWF001946
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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 10 16  1  0  0  0  0
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 13 18  1  0  0  0  0
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 11 14  1  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001946

>  <SMILES>
CO[C@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1cc2ccccc2o1

$$$$
SWF001947
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8527    5.3555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2382    7.0441   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001947

>  <SMILES>
CC(C)NC(=O)N1CCCC2(COCCN(c3ccccc3)C2)C1

$$$$
SWF001948
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 15 18  1  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001948

>  <SMILES>
c1ccc(CN2CCOC3(CCN(CC4CC4)CC3)C2)nc1

$$$$
SWF001949
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001949

>  <SMILES>
CC(C)C(=O)NC1COCCC12CCN(Cc1cnn(C)c1)CC2

$$$$
SWF001950
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4474   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3291   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8209   -1.8410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6007   -4.5816   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0925   -4.4248   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001950

>  <SMILES>
O=C(c1ccnnc1)N1CCC2(CCC(C(=O)N3CCCC3)O2)CC1

$$$$
SWF001951
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  5  8  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001951

>  <SMILES>
Cc1oncc1C(=O)N1C[C@@H](c2ccccc2)[C@@]2(CCNC2=O)C1

$$$$
SWF001952
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  8 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  7 10  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001952

>  <SMILES>
Cc1cccc(C(=O)N2CCCC3(CCCC(=O)N3C)C2)c1

$$$$
SWF001953
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.9711    6.1298   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2211    4.8308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4383    5.8179   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2248    3.7160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5951    4.3261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001953

>  <SMILES>
O=C(Cc1ccccn1)N1CCC2(CCN(Cc3nccs3)C2)CC1

$$$$
SWF001954
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    4.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001954

>  <SMILES>
N#Cc1ccc(OC[C@]23COC[C@H]2CN(C(=O)c2cocn2)C3)nc1

$$$$
SWF001955
Actelion Java MolfileCreator 1.0

 22 26  0  0  1  0  0  0  0  0999 V2000
    2.4487    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.9706    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3336    2.3239   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8554    2.9820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4381    3.3184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  1  0  0  0
 11  8  1  1  0  0  0
  9 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001955

>  <SMILES>
c1cnc(N2C[C@@H]3C[C@@H](c4nc(C5CC5)cs4)O[C@@H]3C2)nc1

$$$$
SWF001956
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8  9  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001956

>  <SMILES>
O=C(c1cnccn1)N1CC[C@H]2[C@H]1CCN2S(=O)(=O)C1CC1

$$$$
SWF001957
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 11 12  2  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001957

>  <SMILES>
O=C(c1ccco1)N1CCc2ncc(CN3CCCC3)n2CC1

$$$$
SWF001958
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001958

>  <SMILES>
Cc1nc([C@H]2C[C@H]3CN(C(=O)C4CCOCC4)CC[C@@H]3O2)no1

$$$$
SWF001959
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF001959

>  <SMILES>
Cc1ccc(CN2CCc3cc(C(=O)N4CCCC4)c(N(C)C)nc3CC2)o1

$$$$
SWF001960
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  2  0  0  0  0
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 19 21  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001960

>  <SMILES>
CS(=O)(=O)N1CC[C@H]2OCC[C@@H](C(=O)N3CCCO3)[C@@H]2C1

$$$$
SWF001961
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7617    3.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6277    3.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956    2.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2617    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001961

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2COC[C@@H](CC(=O)N3CCCCO3)[C@@H]2C1

$$$$
SWF001962
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 22 24  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF001962

>  <SMILES>
O=C(C[C@]12COC[C@H]1CN(Cc1ccco1)C2)NCc1cccnc1

$$$$
SWF001963
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 15  1  1  0  0  0
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 13 18  2  0  0  0  0
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 22 24  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF001963

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1CCO[C@H]2CCN(CC3CC=CO3)C[C@@H]21

$$$$
SWF001964
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 19 21  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF001964

>  <SMILES>
Cc1ccccc1NC(=O)C1c2c(ncn2C(C)C)CCN1Cc1ccccc1

$$$$
SWF001965
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001965

>  <SMILES>
CN(C)C(=O)C[C@@H]1COC[C@H]2CN(Cc3ccccc3)C[C@@H]12

$$$$
SWF001966
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -8.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001966

>  <SMILES>
c1ccc(CN2CCOC3(CCN(Cc4ccco4)CC3)C2)nc1

$$$$
SWF001967
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3291   -1.9978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1759    1.7996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2778    3.3267   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001967

>  <SMILES>
O=C(c1ccnnc1)N1CCC2(CC1)CCN(CC1CC1)C2=O

$$$$
SWF001968
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  6  0  0  0
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  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001968

>  <SMILES>
Cc1cccc(CN2CCC[C@]3(C[C@@H](Oc4ccccn4)CO3)C2)n1

$$$$
SWF001969
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001969

>  <SMILES>
Cc1ccc(CN2CCC3(C2)CN(c2ccccc2)C(=O)CN3C)o1

$$$$
SWF001970
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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    3.8258    3.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  1  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001970

>  <SMILES>
CC(=O)N1CCC2(COCc3c(C)nc(NCC4CC4)nc32)C1

$$$$
SWF001971
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.3923    5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF001971

>  <SMILES>
O=C(CC1CCC2(CC1)CCN(C(=O)c1cnccn1)CC2)N1CC=CC1

$$$$
SWF001972
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.4098   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0031   -1.2522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5031   -0.3862   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8339    0.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9204   -0.0498   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0419    1.3351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2987    2.0042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  2  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001972

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(C(=O)NCc4ccccc4)C[C@@H]32)C(=O)N1

$$$$
SWF001973
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4839   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9016   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8961   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3029   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2974   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7151   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
  8 11  1  0  0  0  0
 12 14  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001973

>  <SMILES>
CC(=O)N1CCC2(CC1)CC(CC(=O)NC1CCC1)c1ccccc12

$$$$
SWF001974
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2033   -5.1335   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8134   -6.5038   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9392    2.4955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  6  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001974

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cccc(OC)c3)CC2)CN1C

$$$$
SWF001975
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9345    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4345    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9345    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4345    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9400    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3412   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9345    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9345    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9345    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9345    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001975

>  <SMILES>
O=C(c1ccccn1)N1C[C@@H]2COC[C@]2(CN2CCCCC2)C1

$$$$
SWF001976
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 12  2  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001976

>  <SMILES>
CS(=O)(=O)NCc1cnc2n1CCN(c1ncccn1)CC2

$$$$
SWF001977
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   10.6728   -0.4310   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6691   -1.5457   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7383    0.1927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5998   -3.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 10 14  1  0  0  0  0
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 17 18  2  0  0  0  0
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M  END
>  <HTSID>
SWF001977

>  <SMILES>
CNC(=O)c1cnc2n1CCN(C(=O)c1ccc3[nH]ccc3c1)C2

$$$$
SWF001978
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   12.5768   -4.0767   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001978

>  <SMILES>
c1ccc(COC2COC3(CCN(CC4CCOCC4)CC3)C2)cc1

$$$$
SWF001979
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001979

>  <SMILES>
COCC(=O)N1CCC2(CC1)CC(OCc1ccccn1)CO2

$$$$
SWF001980
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
 13  9  1  1  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001980

>  <SMILES>
Cc1nnc([C@H]2C[C@@H]3CCN(C(=O)Cc4ccccc4)C[C@H]3O2)[nH]1

$$$$
SWF001981
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2169   -2.3499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.7937   -2.9499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6127   -1.2273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2004   -2.0363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3815   -3.7589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001981

>  <SMILES>
C=CCOC1COC2(CCCN(Cc3cccc(C)n3)C2)C1

$$$$
SWF001982
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4834    4.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852    5.9672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1254    8.5085   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1291    9.6232   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6582    8.8204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6656   11.0498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1947   10.2470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1984   11.3617   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001982

>  <SMILES>
O=C(NCc1ccco1)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccncc2)O1

$$$$
SWF001983
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5116   -1.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7026   -2.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1808   -2.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6808   -3.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0875   -4.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001983

>  <SMILES>
Cn1cc(CN2CC[C@@H]3OCC[C@H](C(=O)Nc4cccnc4)[C@H]3C2)cn1

$$$$
SWF001984
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  1  1  6  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 23 26  2  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF001984

>  <SMILES>
c1ccc(C[C@H]2CN(c3ncccn3)CC[C@H]2Oc2cccnc2)cc1

$$$$
SWF001985
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6000   -0.3217   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4090    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0782   -1.3956   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0782    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0782   -1.3956   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5782   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF001985

>  <SMILES>
O=C(c1cc2ccccc2o1)N1CC[C@]2(C[C@H](OCC3CC3)CO2)C1

$$$$
SWF001986
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001986

>  <SMILES>
O=C(c1ncccn1)N1C[C@@H]2CN(Cc3ccco3)CCO[C@@H]2C1

$$$$
SWF001987
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7820   -4.6894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001987

>  <SMILES>
Cc1csc(CN2C[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)n1

$$$$
SWF001988
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6285   -0.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF001988

>  <SMILES>
C=CCO[C@H]1CC[C@H]2[C@H]1OCCN2Cc1cccnc1OC

$$$$
SWF001989
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.4020    0.7412   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF001989

>  <SMILES>
Cc1cccc(CN2CCC3(CCN(C(=O)C(C)C)C3)C2=O)c1

$$$$
SWF001990
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.0933    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001990

>  <SMILES>
CN1C(=O)CCCC12CCCN(C(=O)CCc1ccccc1)C2

$$$$
SWF001991
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2902    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2413    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2413    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0503    2.5365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF001991

>  <SMILES>
Cc1ccc(CN2C[C@@H]3COC[C@]3(CNC(=O)c3ccno3)C2)o1

$$$$
SWF001992
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.0057    1.2580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0057   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4323    0.7944   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4323   -0.7056   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001992

>  <SMILES>
CO[C@@H]1CCN(Cc2ccoc2)[C@@H]2CN(Cc3ccco3)C[C@@H]21

$$$$
SWF001993
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6273    1.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3658    2.9590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8245    3.4992   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2511    3.9627   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5629    5.4299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4482    6.4336   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6050    7.9254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9810    6.1217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2347    8.5355   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2310    7.4208   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  1  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001993

>  <SMILES>
c1cncc(OC[C@@H]2CCC[C@@]23CN(Cc2ccoc2)CCO3)c1

$$$$
SWF001994
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   11.4305    4.1366   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5488    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8571    3.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4305    1.7095   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0488    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8571    2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2988    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8071    1.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9089    0.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF001994

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1COC[C@H]2CN(Cc3nccs3)C[C@H]21

$$$$
SWF001995
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5139    0.1235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888   -0.0990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5139   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9227   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2914   -3.0984   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888   -1.9010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF001995

>  <SMILES>
O=C1NCCO[C@H]2CN(Cc3ccc(Cl)c(F)c3)CC[C@@H]12

$$$$
SWF001996
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2709   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2709   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7709   -1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF001996

>  <SMILES>
CCn1cc2c(n1)CN(C(=O)/C=C/c1cccs1)CC2COC

$$$$
SWF001997
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    6.5907   -0.1910   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2709   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6831   -1.8090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  6  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  7  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF001997

>  <SMILES>
c1csc([C@@H]2C[C@@H]3CCN(Cc4ccc5c(c4)OCO5)C[C@H]3O2)n1

$$$$
SWF001998
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6093   -1.9069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2492   -0.2127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5874   -1.6990   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2273   -0.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8964   -0.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF001998

>  <SMILES>
c1cncc(CN2CCO[C@H]3[C@H](Oc4cccnc4)CC[C@@H]32)c1

$$$$
SWF001999
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    4.4646   -3.0810   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5793   -2.0773   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0059   -2.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3178   -4.0081   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1206   -1.5372   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7383    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8951    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9519   -0.0652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5248    2.9184   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2655    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3222    0.5449   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2130    4.3856   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4790    2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277    5.3893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7864    4.8491   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  2  0  0  0  0
  6 11  1  0  0  0  0
  6 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 21 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 27 30  2  0  0  0  0
 10 12  1  0  0  0  0
 13 15  1  0  0  0  0
 19 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF001999

>  <SMILES>
Cc1ccccc1NC(=O)c1cc2c(c3ccccc3n2C(C)C)n1C(=O)N(C)C

$$$$
SWF002000
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.9480   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6747   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0567   -4.3761   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7779   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657   -5.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  9 11  1  0  0  0  0
 12 14  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002000

>  <SMILES>
C=CCO[C@H]1CN(C(=O)c2cc(C)[nH]c2C)[C@@H]2CCCO[C@H]12

$$$$
SWF002001
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.5776   -3.4840   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0411   -2.0575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0374   -0.9427   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.5083   -1.7456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5009    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1184   -0.3753   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6230   -2.7493   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4972    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6102   -0.5321   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3684    0.9238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9221   -1.9993   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0300    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1184    2.2228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2924   -2.6094   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002001

>  <SMILES>
C=CCO[C@H]1CC[C@H]2[C@@H]1OCCN2C(=O)c1cc(C)nn1CC

$$$$
SWF002002
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3850   -2.3227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6941   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0789   -0.2502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4153   -1.8329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0735   -0.3547   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5789    0.6158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2814   -1.3329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1949   -1.7396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002002

>  <SMILES>
C=CCO[C@H]1CC[C@H]2[C@@H]1OCCN2C(=O)c1cc(C)[nH]c1C

$$$$
SWF002003
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5779    2.0698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6508    4.9230   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5816    3.1845   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2654    5.0218   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9939    7.6056   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6040    8.9760   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5021    7.4488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7223   10.1895   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3796    8.6624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2305   10.0327   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 10  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002003

>  <SMILES>
C=CCC(=O)N1C[C@H](OCc2ccncc2)[C@H]2OCCC[C@H]21

$$$$
SWF002004
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.1752    8.0154   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7853    6.6450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2900    9.0191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2771    6.8018   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    5.3460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5890    8.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7853    4.0470   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0353    2.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    4.0470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0353    2.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
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 15 17  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002004

>  <SMILES>
O=C(NC1CCC12CCN(Cc1nccs1)CC2)c1cnccn1

$$$$
SWF002005
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.8456    2.1450   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8456    2.1450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3456    0.6061   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1546    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF002005

>  <SMILES>
O=C(NCc1ccco1)C1C2CCC(C2)N1Cc1nccs1

$$$$
SWF002006
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7500   -6.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7500   -8.0491   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
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 11 12  1  0  0  0  0
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 12 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002006

>  <SMILES>
CC1CC1C(=O)N1Cc2ccnn2C(C(=O)N2CCC(F)(F)CC2)C1

$$$$
SWF002007
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  7  6  1  1  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002007

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CNC(=O)CN3CC3CC3)C2)cn1

$$$$
SWF002008
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.3569    1.8320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -0.7929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2005    0.3004   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3915    1.7016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8696    1.0435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3696    1.9095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002008

>  <SMILES>
O=C(c1cc[nH]n1)N1CCCC2(C1)CN(CCN1CCCC1)C2=O

$$$$
SWF002009
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    8.4623   -0.0151   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.1314   -0.7582   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7931    0.7281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7191   -0.6842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2054    0.6541   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7681   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 12  1  6  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002009

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CO[C@@H]2CN(C(=O)COC3CCCC3)C[C@H]12

$$$$
SWF002010
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8676    1.0569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0685    0.8368   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1920   -1.1091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1280    0.6343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5573   -0.1782   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8684   -1.8456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5687   -2.7997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2451   -3.5362   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5927   -3.0172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9455   -4.4903   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2930   -3.9713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -4.7078   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002010

>  <SMILES>
Fc1cccnc1OC1C2CCC1N(Cc1ccccn1)CCO2

$$$$
SWF002011
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511   -2.2908   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875   -1.6522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2026    1.8605   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8717    2.6037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  8  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002011

>  <SMILES>
Cc1ncsc1CN1C[C@H](C(=O)NC2CCC2)[C@H]2OCC[C@H]21

$$$$
SWF002012
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.8323    1.0606   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0823    2.3597   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.8834    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9441   -0.3882   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128    0.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -7.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  1  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5  6  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002012

>  <SMILES>
O=C(NCCC1CN(C2CCOCC2)Cc2ccnn21)C1CC(F)(F)C1

$$$$
SWF002013
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2024    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2024    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2024    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2024    2.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2024    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002013

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1cccnc1)C2)C1CCC1

$$$$
SWF002014
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393    0.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5326    1.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689    1.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002014

>  <SMILES>
Cn1nnc2c1C(COCc1ccccn1)CN(C(=O)c1ccccn1)C2

$$$$
SWF002015
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5139    0.1235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888   -0.0990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5139   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9227   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2914   -3.0984   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888   -1.9010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
  8 10  1  0  0  0  0
 17 19  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002015

>  <SMILES>
O=C1NCCO[C@H]2CN(C(=O)Cc3csc4ccccc34)CC[C@@H]12

$$$$
SWF002016
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3917    0.5649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4839   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9016   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2106   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0984   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4016   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4074   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  8  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002016

>  <SMILES>
O=C(C1CN(C(=O)C2(F)CCC2)C2CCOC12)N1CCCC1

$$$$
SWF002017
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8974   -3.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -3.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8974   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -4.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002017

>  <SMILES>
Cc1cc(CN2CC[C@]3(C[C@@H](Oc4ccccn4)CO3)C2)no1

$$$$
SWF002018
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9863   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -8.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002018

>  <SMILES>
O=S(=O)(NCC1CCC2(CN(Cc3ccccn3)C2)OC1)C1CC1

$$$$
SWF002019
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.7498    2.1731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0488    1.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0488    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9998    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9998    3.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6099   -0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6099    4.8424   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080    3.6289   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    5.8461   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.0961   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814   -1.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002019

>  <SMILES>
Cn1cnc(S(=O)(=O)N2C[C@@H]3COC[C@]3(COCC3CC3)C2)c1

$$$$
SWF002020
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.5907   -0.1910   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  6  0  0  0
 10 12  1  1  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002020

>  <SMILES>
Cn1cc(CN2CC[C@@H]3CN(c4nncs4)C[C@H]3C2)cn1

$$$$
SWF002021
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6717    1.2900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8796    2.2682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002021

>  <SMILES>
COc1ccccc1CN1CC2(C1)OCCC2COCC1CC1

$$$$
SWF002022
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2341   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5665   -4.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -7.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -5.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002022

>  <SMILES>
Cn1cnc(S(=O)(=O)N2Cc3ccnn3C(CN3CCCC3)C2)c1

$$$$
SWF002023
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0575    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5493    0.7429   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1759    1.7996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1594    2.1132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7860    3.1699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2778    3.3267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6512    2.2700   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002023

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)CCN(CC2CC2)C3=O)n1

$$$$
SWF002024
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9464    2.8559   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7608    3.4511   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1374    3.4436   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1817    4.4591   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 14  2  0  0  0  0
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 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  8 10  1  0  0  0  0
 10 13  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002024

>  <SMILES>
O=C(COc1ccccc1)N1CC2CCC1C2OCC1CC1

$$$$
SWF002025
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.8456   -3.7589   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6888   -2.2671   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3185   -1.6570   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9023   -1.3855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1617   -0.1652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499   -2.7097   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7455    0.1063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3752    0.7164   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8976    0.6423   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7606   -2.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9590    0.9880   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4781    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002025

>  <SMILES>
Cc1cc(=O)n2c(n1)CCC1(CCN(C(=O)C3(C)CC=CCC3)C1)CC2

$$$$
SWF002026
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3971    5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3971    5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8435   12.1284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  6  0  0  0
 21 23  1  6  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002026

>  <SMILES>
O=C(NCC1CC1)C1C[C@@H]2CCN(C(=O)C3[C@H]4COC[C@@H]34)C[C@@H]2O1

$$$$
SWF002027
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
 17 19  1  6  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002027

>  <SMILES>
O=C1NC2(CCN(C(=O)c3cscn3)CC2)CC1c1cccnc1

$$$$
SWF002028
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.6242    1.4031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.6211    1.4815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5121    1.9355   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1671    2.3725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
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 13 12  1  6  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002028

>  <SMILES>
O=C(NC[C@@H]1OC[C@H]2CN(C(=O)C3(F)CCC3)CC[C@H]21)C1CC1

$$$$
SWF002029
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.1168    0.6443   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9033    1.5260   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3566   -1.3361   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9392    2.4955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002029

>  <SMILES>
COCC1CC2(CCN(S(=O)(=O)N(C)C)CC2)CN1C

$$$$
SWF002030
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.1449    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2788    1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4128    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2788    2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3083    0.2079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4993    1.6092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4128    3.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    0.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4128    4.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    4.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808    3.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  9  6  1  1  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  1  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
  9 12  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002030

>  <SMILES>
CC(C)NC(=O)C[C@H]1[C@H]2CN(C(=O)Cc3ccccn3)C[C@@H]12

$$$$
SWF002031
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002031

>  <SMILES>
Cn1cnc(C(=O)N2CCc3ncnc(-c4ccccc4)c3C2)n1

$$$$
SWF002032
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  1  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 16 22  1  0  0  0  0
 18 23  1  0  0  0  0
 18 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 21 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002032

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1C[C@H]2OCC[C@H]2[C@H](C(=O)N2CCCC2)C1

$$$$
SWF002033
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.1444    2.5248   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0546    2.7416   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6525    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002033

>  <SMILES>
O=C(N1C[C@H]2CCCC(OCc3cccnc3)[C@H]2C1)C1(F)CCC1

$$$$
SWF002034
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002034

>  <SMILES>
O=C(CN1CCCCC1)N1CCC2(CCCN(c3ncccn3)C2)CC1

$$$$
SWF002035
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7173   -3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  7  9  1  0  0  0  0
 10 12  1  0  0  0  0
 17 18  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002035

>  <SMILES>
Cc1nnc(N2CCCC3(CN(Cc4ccoc4)CCO3)C2)o1

$$$$
SWF002036
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
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 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002036

>  <SMILES>
Cc1ccc(CN2C[C@@H]3CN(C(=O)c4cnoc4C)C[C@@H]3C2)cc1

$$$$
SWF002037
Actelion Java MolfileCreator 1.0

 33 38  0  0  0  0  0  0  0  0999 V2000
    6.6227   -0.2865   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 30 32  2  0  0  0  0
 31 33  2  0  0  0  0
  4  6  1  0  0  0  0
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 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 26  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF002037

>  <SMILES>
Cn1nc2c(c1O)CN(Cc1ccc3c(c1)OCO3)CC21CCN(Cc2ccccc2)CC1

$$$$
SWF002038
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 17 18  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002038

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3cc(C(C)=O)[nH]n3)C[C@H]2C)C1=O

$$$$
SWF002039
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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    9.4182   -1.9463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
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 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002039

>  <SMILES>
O=C(C1=CCCC1)N1CCC(Nc2ccc(F)cn2)(C(=O)NC2CC2)CC1

$$$$
SWF002040
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.3792   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5067   -0.3508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    0.7497   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1940    1.2367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002040

>  <SMILES>
C1CCC(CN2CCOCC3(CCN(C4CCOCC4)C3)C2)CC1

$$$$
SWF002041
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 15 14  1  1  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002041

>  <SMILES>
O=C(Nc1cccc(Cl)c1)C1=NOC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002042
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.3615    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002042

>  <SMILES>
c1ccc(CO[C@@H]2CO[C@@]3(CCN(C4CCOCC4)C3)C2)nc1

$$$$
SWF002043
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
 11  7  1  6  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002043

>  <SMILES>
Cn1cc(CN2CC[C@@H]3O[C@@H](C(=O)N4CCCC4)C[C@@H]32)cn1

$$$$
SWF002044
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.3509   -2.1667   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.6667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6188   -2.1667   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -3.6667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6188   -1.1667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7528   -2.6667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002044

>  <SMILES>
O=C(C1CCOC1)N1CC2CC(CN(Cc3cccnc3)C2)C1

$$$$
SWF002045
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5920   -3.3024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8055   -1.2006   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0592   -3.6143   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6693   -4.9846   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1611   -5.1414   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7712   -6.5118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2630   -6.6685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5346   -4.0847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1447   -5.4550   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  7 10  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002045

>  <SMILES>
O=S(=O)(C1CC1)N1CC2(CCN(Cc3ccncc3)C2)C1

$$$$
SWF002046
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2500    0.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9843    4.9810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    4.9810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    6.4434   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    6.4434   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    7.0942   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    9.3442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   10.8442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   11.5942   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    9.3442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   10.8442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002046

>  <SMILES>
CC1(C)CC1C(=O)N1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF002047
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    9.7406    7.7711   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.2406    7.7711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4906    9.0702   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    9.0702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2406    7.7711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7406    5.1731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    3.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3805    2.5037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4824    3.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  1  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002047

>  <SMILES>
CN(C)C(=O)COC1CCC[C@@H]2CN(C(=O)c3ccnc(F)c3)C[C@H]12

$$$$
SWF002048
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
   13.9380    2.7971   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    5.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9696    3.4072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1831    1.3053   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    5.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9659    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7159    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    7.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4827    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1679   -0.4028   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    8.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    8.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3831    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002048

>  <SMILES>
COCCCN1CC[C@@H]2CN(C(=O)/C=C/C(C)C)C[C@@H]2CC1

$$$$
SWF002049
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342   -5.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9063   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002049

>  <SMILES>
c1cnc(OC2CCOC3(C2)CN(Cc2ccc4c(c2)OCO4)C3)nc1

$$$$
SWF002050
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10  7  1  1  0  0  0
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 11 13  1  0  0  0  0
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  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002050

>  <SMILES>
O=C(NCC1CN(CC2CCCC2)Cc2ccnn21)N1CCCC1

$$$$
SWF002051
Actelion Java MolfileCreator 1.0

 29 34  0  0  1  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
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 20 15  1  6  0  0  0
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 23 28  1  0  0  0  0
 24 29  1  0  0  0  0
  4  7  1  0  0  0  0
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 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 22 27  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002051

>  <SMILES>
O=C(COC1CSC2(C1)CN(C(=O)C13C[C@H]4C[C@@H](C1)C[C@@H](C3)C4)C2)N1CCCC1

$$$$
SWF002052
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF002052

>  <SMILES>
Cc1ccc(CC(=O)N2CCCC3(C2)CN(C(C)C)Cc2cncn23)cc1

$$$$
SWF002053
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 15  2  0  0  0  0
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 17 20  2  0  0  0  0
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 11 16  1  0  0  0  0
 14 15  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002053

>  <SMILES>
CC1CC1C(=O)N1Cc2ccnn2C(C(=O)NCC2CCOCC2)C1

$$$$
SWF002054
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.2715    4.8885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5283    4.2194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 23  1  0  0  0  0
 13 14  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF002054

>  <SMILES>
COCc1nnc2n1CCN(C(=O)CC1=CCCCC1)C(C)C2

$$$$
SWF002055
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8868   -1.1667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7528   -3.6667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002055

>  <SMILES>
CCN1CC2CN(C(=O)Cc3ccc(OC)c(F)c3)CC(C1)O2

$$$$
SWF002056
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.1665    3.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    4.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733    5.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    4.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    2.4781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733    1.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    5.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  1  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002056

>  <SMILES>
Cc1noc(CC(=O)N2CC[C@H]3C[C@H](C(=O)N4CCCC4)O[C@@H]3C2)n1

$$$$
SWF002057
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.3018   -0.2530   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4511   -0.7787   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5258   -0.3995   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3764   -1.7759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4049   -2.0130   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0685   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002057

>  <SMILES>
CN1C(=O)CCC12CCCN(Cc1ccc3c(c1)CCC3)CC2

$$$$
SWF002058
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    0.6811    3.9801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002058

>  <SMILES>
COCC1CN(Cc2ccccn2)CC12CCN(C(=O)CC1CC1)CC2

$$$$
SWF002059
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9  5  1  6  0  0  0
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  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002059

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(C2)CN(Cc2ccccn2)c2cccnc23)n1

$$$$
SWF002060
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    5.7340   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002060

>  <SMILES>
O=C(N1CCCC1)N1CC[C@H]2[C@H]1CC(=O)N2Cc1ccncc1

$$$$
SWF002061
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8961   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 13 12  1  6  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002061

>  <SMILES>
O=C(C1=CCCC1)N1CCC[C@]2(C[C@@H](Oc3ncccc3F)CO2)C1

$$$$
SWF002062
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776    2.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002062

>  <SMILES>
COC[C@H]1CCC[C@]12CN(C(=O)NCc1ccccc1)CCO2

$$$$
SWF002063
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    9.0413   -2.6730   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2492   -3.6511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002063

>  <SMILES>
O=C(NCC1CC1)[C@H]1C[C@@H]2CCN(Cc3nccs3)C[C@@H]2O1

$$$$
SWF002064
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    2.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -2.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002064

>  <SMILES>
O=C(c1ncccn1)N1C[C@H]2CCC[C@@]2(COCc2cccnc2)C1

$$$$
SWF002065
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.5377    3.7698   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.8367    3.0198   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.8367    4.5198   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7877    2.4707   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7877    5.0688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6327    1.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2919    2.5828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7877    6.5688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4887    5.8188   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1906   -0.2020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2716    1.4832   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002065

>  <SMILES>
CN(C)CCN1CCOC2CCN(S(=O)(=O)C3CC3)CCC21

$$$$
SWF002066
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.9073   -0.2319   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -1.2264   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8028    0.7626   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128   -0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9018   -0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128   -1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347   -0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  7  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002066

>  <SMILES>
CS(=O)(=O)N1CC[C@@]2(C[C@H](NC(=O)c3ccncc3)CCO2)C1

$$$$
SWF002067
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480   -1.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291    0.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4426   -1.2862   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6236    0.4364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002067

>  <SMILES>
O=C1N(c2cncnc2)CCC12CCCN(Cc1ccccn1)C2

$$$$
SWF002068
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3364   -4.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -5.7283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -6.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -5.8974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1045   -7.3919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  6  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 12  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002068

>  <SMILES>
Cc1ccc(CN2C[C@@H]3COC[C@@H](CC(=O)N4CCOCC4)[C@@H]3C2)o1

$$$$
SWF002069
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    5.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002069

>  <SMILES>
c1cc(COCC23CCCOC2CCN(CC2CC2)C3)ccn1

$$$$
SWF002070
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.5907   -0.1910   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5907   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5418   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3508    0.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -0.1910   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3508   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  6  0  0  0
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  8  1  1  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002070

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(C(=O)c4ccnnc4)C[C@H]3O2)sc1C

$$$$
SWF002071
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002071

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cc[nH]n3)CC2)CN1CC1CC1

$$$$
SWF002072
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.5263   -5.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002072

>  <SMILES>
C=CCOC1C2CCCC1CN(C(=O)Cc1ccc(F)cn1)C2

$$$$
SWF002073
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.6691   -1.5457   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3572   -3.0129   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7838   -2.5494   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6728   -0.4310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9847    1.0362   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 12 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002073

>  <SMILES>
CC1c2ncc(COc3cccnc3)n2CCN1S(=O)(=O)C1CC1

$$$$
SWF002074
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.7117    1.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002074

>  <SMILES>
C=CCN1CCOC2CN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CCC2C1

$$$$
SWF002075
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002075

>  <SMILES>
Cc1cccc(CN2CC3(CCN(C(=O)C4CC4C)CC3)CC2=O)c1

$$$$
SWF002076
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 17  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002076

>  <SMILES>
Cc1noc(C)c1C(=O)N1CCCC2(C1)CN(C(C)C)Cc1cncn12

$$$$
SWF002077
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002077

>  <SMILES>
COc1ncccc1CN1CC[C@H]2OCC[C@@]2(C(=O)NC2CC2)C1

$$$$
SWF002078
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0820   -1.5477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002078

>  <SMILES>
Cc1ncsc1CN1C[C@@H](OCC2CC2)[C@H]2OCCC[C@H]21

$$$$
SWF002079
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
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 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002079

>  <SMILES>
Cn1cc(C(=O)N2CC3(CC(OCc4cccnc4)CS3)C2)cn1

$$$$
SWF002080
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 16 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 11  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002080

>  <SMILES>
COCC1COCCC12CCN(C(=O)CCc1ccccc1)CC2

$$$$
SWF002081
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.8235    1.0873   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.9280    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002081

>  <SMILES>
O=C(c1cscn1)N1CCC[C@]2(C[C@H](OCC3CC3)CO2)C1

$$$$
SWF002082
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
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 10 14  1  0  0  0  0
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 10 11  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002082

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF002083
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  1  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 12  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002083

>  <SMILES>
O=C(CN1CCCC2(CCCN(C(=O)CCn3cccn3)C2)C1)N1CCCC1

$$$$
SWF002084
Actelion Java MolfileCreator 1.0

 31 36  0  0  0  0  0  0  0  0999 V2000
    2.8634   -6.1086   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  6  1  0  0  0  0
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 10 12  2  0  0  0  0
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 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  1  0  0  0  0
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 25 29  2  0  0  0  0
 26 30  1  0  0  0  0
 30 31  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 18  1  0  0  0  0
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 27 28  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002084

>  <SMILES>
Cn1cc(CN2Cc3cnc(N4CCOCC4)nc3C3(CCN(CC4CC4)C3)C2)cn1

$$$$
SWF002085
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 10 13  2  0  0  0  0
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 16 20  2  0  0  0  0
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 17 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 11 12  2  0  0  0  0
 18 22  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002085

>  <SMILES>
O=C(NCc1cccnc1)N1CCc2ncnc(C3CC3)c2CC1

$$$$
SWF002086
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 17 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 11  9  1  6  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
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M  END
>  <HTSID>
SWF002086

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H]2CO[C@H](CN3CCOCC3)[C@H]2C1

$$$$
SWF002087
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002087

>  <SMILES>
O=C1CC(c2cccnc2)C2(CCN(C(=O)c3ccncc3)CC2)N1

$$$$
SWF002088
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  8  1  0  0  0  0
 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002088

>  <SMILES>
O=C(c1ccc(Cl)c(F)c1)N1CCCC2(CCCN2CC2CCCO2)CC1

$$$$
SWF002089
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
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 20 15  1  1  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  6  0  0  0
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 25 27  1  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002089

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3)C2=O)n1

$$$$
SWF002090
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1682    4.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 13  2  0  0  0  0
 19 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002090

>  <SMILES>
CCn1nccc1C(=O)N1CCCC2(CCCN(Cc3ccnn3C)C2)C1

$$$$
SWF002091
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3052    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 16 20  1  6  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 16  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002091

>  <SMILES>
COc1ccccc1OCC(=O)N1CC2(CC(CO)CN2C)C1

$$$$
SWF002092
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4909    1.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4209    2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002092

>  <SMILES>
Cc1ncc(CN2CCCC3(C2)CN(c2ccc(=O)n(C)c2)C3=O)s1

$$$$
SWF002093
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    4.2109    3.8010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7027    3.6442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3128    2.2739   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5843    4.8577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5628    0.9748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7800    1.9620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9547    5.4678   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7411    6.3495   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9368    0.4702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1682    6.3495   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2047    7.7761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7047    7.7761   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002093

>  <SMILES>
CN1C[C@@H](COCC2CC2)[C@]2(CCN(C(=O)C3[C@H]4COC[C@@H]34)C2)C1

$$$$
SWF002094
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002094

>  <SMILES>
O=C(C[C@H]1CO[C@@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]12)N1CCCC1

$$$$
SWF002095
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    6.0061   -1.4432   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4128   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5819    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1475   -3.2962   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002095

>  <SMILES>
CC(C)N(C)CC(=O)N1C[C@@H](C)[C@@]2(CCN(CCN3CCCC3)C2=O)C1

$$$$
SWF002096
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228    1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5549    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.1529    1.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  3  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002096

>  <SMILES>
Cc1nc(COC2CCOC3(C2)CN(C(=O)c2cccc(C#N)c2)C3)cs1

$$$$
SWF002097
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    8.4425   -1.4750   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.9541   -4.5683   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  2  0  0  0  0
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 13 18  1  0  0  0  0
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 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 17 23  1  0  0  0  0
 18 24  2  0  0  0  0
 20 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 30 32  2  0  0  0  0
 31 33  2  0  0  0  0
  4  7  1  0  0  0  0
 12 13  2  0  0  0  0
 19 24  1  0  0  0  0
 21 25  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF002097

>  <SMILES>
O=C(NCCCn1ccnc1)c1nc(-c2cnc(NCc3ccccn3)s2)n2ccccc12

$$$$
SWF002098
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.4505   -1.3929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1273   -2.3392   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1462   -2.5325   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7852   -3.0923   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5463   -1.7323   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 17  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002098

>  <SMILES>
CC(C)N(C)CC1COC2(COCCN(C(=O)c3cnccn3)C2)C1

$$$$
SWF002099
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002099

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCN(C3CCOC3)C2)C1

$$$$
SWF002100
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.4347    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0819    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6341   -0.1248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4262   -1.1030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5852    0.1842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002100

>  <SMILES>
O=C(NCCc1ccccn1)c1cc2c(s1)CCN2C(=O)C1CC1

$$$$
SWF002101
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002101

>  <SMILES>
O=C(NCc1cccnc1)[C@H]1C[C@@H]2CCN(c3ccncn3)C[C@H]2O1

$$$$
SWF002102
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  2  0  0  0  0
 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002102

>  <SMILES>
CN(C)C(=O)N[C@H]1c2ccccc2[C@@H]2CN(c3ncccn3)C[C@@H]21

$$$$
SWF002103
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   12.0455   -0.7842   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.2023   -2.2760   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5373   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  1  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002103

>  <SMILES>
CS(=O)(=O)N1CCC2(CCC(C(=O)NCC3CC3)O2)CC1

$$$$
SWF002104
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13  9  1  1  0  0  0
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 10 15  1  1  0  0  0
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 22 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002104

>  <SMILES>
COc1ncccc1CN1C[C@@H](C(=O)NCC2CC2)C[C@H]2OCC[C@H]21

$$$$
SWF002105
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 22 23  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002105

>  <SMILES>
CN(C)C(=O)N[C@@H]1CCO[C@]2(CCN(Cc3cnn(C)c3)C2)C1

$$$$
SWF002106
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.4556    2.4274   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 16 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002106

>  <SMILES>
O=C(CC1=CCCCC1)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF002107
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002107

>  <SMILES>
CC(=O)N1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF002108
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.0916    2.6374   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0697    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9871    3.6319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5697    3.2955   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4765    1.5159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9006    4.0386   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9765    0.6499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002108

>  <SMILES>
Cc1cccc(CN2CCCC23CCN(c2nncs2)C3)n1

$$$$
SWF002109
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002109

>  <SMILES>
CN(C)C(=O)C1CC2(CCCN(Cc3cnn(C)c3)C2)CO1

$$$$
SWF002110
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.7498    2.1731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0488    1.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0488    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9998    3.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4998    3.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  1  0  0  0
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002110

>  <SMILES>
O=S(=O)(c1ccccc1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF002111
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002111

>  <SMILES>
O=C([C@H]1CN(Cc2ccccn2)C[C@H]2OCC[C@@H]12)N1CCCO1

$$$$
SWF002112
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    0.5827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1222   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -2.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  5  1  0  0  0  0
  8  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002112

>  <SMILES>
c1ccc(CN2C[C@@H]3COC[C@]3(COCc3ccncc3)C2)cc1

$$$$
SWF002113
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 19 23  1  0  0  0  0
  6  7  1  0  0  0  0
 16 17  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF002113

>  <SMILES>
COCC1Cn2nnc(C)c2CN1C(=O)Cc1ccc(F)cn1

$$$$
SWF002114
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.0205    4.4146   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1044    2.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    4.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    1.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  3  7  1  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002114

>  <SMILES>
O=C(C[C@@H]1COC[C@H]2CN(C(=O)C3(F)CC3)C[C@@H]12)N1CCCO1

$$$$
SWF002115
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    3.3147   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002115

>  <SMILES>
c1cncc(CN2CCO[C@H]3CN(Cc4nc5ccccc5[nH]4)C[C@@H]32)c1

$$$$
SWF002116
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7040   -1.7788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3763   -3.8479   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0173   -2.2400   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0560   -4.8273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8 10  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002116

>  <SMILES>
CO[C@@H]1CCN(C(=O)CN(C)C(C)C)[C@H]1Cc1cnn(C)c1

$$$$
SWF002117
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.0933   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 17 18  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002117

>  <SMILES>
Cn1cnc2c1CC(CO)N(C(=O)COc1ccc(F)cc1)C2

$$$$
SWF002118
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.2617    3.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2617    1.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7329    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002118

>  <SMILES>
COC[C@]12COC[C@H]1CN(C(=O)CC1Cc3ccccc3C1)C2

$$$$
SWF002119
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.2869    1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002119

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)CC3=CCCCC3)C2)CN1C

$$$$
SWF002120
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.6589   -4.1003   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4590   -3.5005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002120

>  <SMILES>
COc1ccc(CN2CCOCC3(CC(=O)N(C)C3)C2)cc1

$$$$
SWF002121
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.3207   -6.7201   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 19  1  1  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002121

>  <SMILES>
COCCC1CCOC12CCN(C(=O)c1ncccn1)CC2

$$$$
SWF002122
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  2  0  0  0  0
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 17 20  1  0  0  0  0
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 20 23  1  0  0  0  0
 11 16  1  0  0  0  0
 14 15  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002122

>  <SMILES>
O=C(NCc1cccnc1)C1CN(C2CCC2)Cc2ccnn21

$$$$
SWF002123
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002123

>  <SMILES>
CC1c2nc(CC(=O)N3CCOCC3)cn2CCN1C(=O)C1Cc2ccccc2O1

$$$$
SWF002124
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 22 24  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002124

>  <SMILES>
Cc1cc(CN2CC[C@@]3(C[C@@H](Nc4ncccn4)CCO3)C2)no1

$$$$
SWF002125
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002125

>  <SMILES>
O=C(NCC1CC1)[C@@]12CCO[C@@H]1CCN(Cc1ccncc1)C2

$$$$
SWF002126
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.2343    3.8384   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398    3.9430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002126

>  <SMILES>
O=C(c1ccnc(F)c1)N1CCC2(CCCN2CC2CC2)C1

$$$$
SWF002127
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002127

>  <SMILES>
O=C(c1ccno1)N1CCC2(CC1)COCCN(c1ncccn1)C2

$$$$
SWF002128
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    0.4162    1.9141   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002128

>  <SMILES>
CCc1ccc(C(=O)N2CCCC3(CCCN3Cc3cccnc3)C2)cn1

$$$$
SWF002129
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.3953   -2.2452   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002129

>  <SMILES>
C=CCN1CCOCC2(CCN(C(=O)C3CC(C)C3)CC2)C1

$$$$
SWF002130
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.4794   -6.7310   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.2294   -5.4320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9794   -6.7310   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1688   -4.3713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5285   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -1.0607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002130

>  <SMILES>
CCOCCC1CCOC2(C1)CN(C(=O)C1CC(F)(F)C1)C2

$$$$
SWF002131
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    3.6038    4.2416   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2806    3.2952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002131

>  <SMILES>
CCN1CC2(CC1=O)CN(C(=O)C(C)C)CCN(C(C)C)C2

$$$$
SWF002132
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 22 24  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002132

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CCC(=O)N(CC3CC3)C2)CC1

$$$$
SWF002133
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 23 24  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002133

>  <SMILES>
CCS(=O)(=O)NCC1CCC2(CN(Cc3ccc(F)cc3)C2)OC1

$$$$
SWF002134
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 22 24  3  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002134

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3cccc(C#N)c3)C[C@H]2C)C1=O

$$$$
SWF002135
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.2497   -4.3738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2608   -4.5229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6374   -3.7410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8955   -5.4537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0027   -2.8102   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0250   -3.1083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7987   -7.0689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002135

>  <SMILES>
CCN1CCOC2CN(C(=O)c3cc(OC)no3)CCC2C1

$$$$
SWF002136
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7347    2.6853   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3643    3.2954   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002136

>  <SMILES>
CC(C)N1CC2(C1)C(COc1ncccn1)CCS2(=O)=O

$$$$
SWF002137
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
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  7 12  1  0  0  0  0
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 25 27  1  0  0  0  0
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 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002137

>  <SMILES>
Cc1cncc(C(=O)N2CCn3cc(CC(=O)N4CC=CC4)nc3C2C)c1

$$$$
SWF002138
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -0.1506    0.0675   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0573    1.0456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2210    3.3620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  3  0  0  0  0
  9 13  1  0  0  0  0
 16 20  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002138

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)Cc1ccc(C#N)cc1)C2

$$$$
SWF002139
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.2080    0.4963   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3479   -2.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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  4  6  1  0  0  0  0
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 15 18  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002139

>  <SMILES>
Cc1nc2c(s1)CN(C(=O)c1ccnn1C)CC21CCN(C(=O)N(C)C)CC1

$$$$
SWF002140
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -3.0738   -6.3332   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2710   -3.8623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002140

>  <SMILES>
COCCC1CCOC12CCN(Cc1cccc(F)c1)CC2

$$$$
SWF002141
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
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 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002141

>  <SMILES>
COCC1CN(C(=O)c2cnn(C)c2)CC12CCN(C)CC2

$$$$
SWF002142
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
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 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002142

>  <SMILES>
CNC(=O)C1CCCC12CCN(Cc1ccc3c(c1)CCO3)C2

$$$$
SWF002143
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.5602    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7681   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF002143

>  <SMILES>
COCCN1CC2CCN(C(=O)c3cc(C)cc(C)c3)C2C1

$$$$
SWF002144
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002144

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF002145
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002145

>  <SMILES>
O=C(CC1CC1)N1CCC2OCCCC2(COc2cccnc2)C1

$$$$
SWF002146
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002146

>  <SMILES>
CN1CC(c2ccccc2)C2(CCN(C(=O)C3(F)CC3)C2)C1=O

$$$$
SWF002147
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   14.3202   -7.7498   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   13.5702   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002147

>  <SMILES>
Cc1cc(CN2CCc3oc(C(=O)NC(C)C)nc3C2)ccc1F

$$$$
SWF002148
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 21 25  2  0  0  0  0
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 20 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF002148

>  <SMILES>
O=C(c1ccnc(F)c1)N1CC2(CC(NCc3cccnc3)CS2)C1

$$$$
SWF002149
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.8099   -4.0292   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002149

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)c1cc(F)ncc1F)C2

$$$$
SWF002150
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
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 14 15  1  0  0  0  0
 20 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002150

>  <SMILES>
Cc1ccc(CC(=O)N2CCOC3(C2)C(=O)N(C(C)C)CC3c2ccccc2)cc1

$$$$
SWF002151
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6665    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6665    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
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  8 12  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
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 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002151

>  <SMILES>
CCOC[C@@]12CCC[C@@H]1CN(C(=O)c1ccc(OC)cc1)C2

$$$$
SWF002152
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   10.1004   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3139   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.5538   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4519   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4005    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0106    4.2267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9087    2.6996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002152

>  <SMILES>
COCCN1CCC2(CN(Cc3cccnc3)CC(F)(F)C2)C1=O

$$$$
SWF002153
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2163    0.4514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6717    1.2900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8796    2.2682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 19 24  1  0  0  0  0
 21 25  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 20 23  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002153

>  <SMILES>
Cc1cccc(CN2CC3(C2)OCCC3COCc2ccncc2)c1

$$$$
SWF002154
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.2617    3.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7383    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2383    0.7167   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  9  6  1  1  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 13 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002154

>  <SMILES>
O=C(Cc1ccccn1)N1C[C@H]2CCC[C@@]2(COc2ccccn2)C1

$$$$
SWF002155
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002155

>  <SMILES>
C=CCN1CCC2(CCN(C(=O)c3ccnnc3)CC2)C1=O

$$$$
SWF002156
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 22 24  1  0  0  0  0
  5  7  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002156

>  <SMILES>
CCN1CC2(CC1=O)CN(Cc1ccc(C)o1)CCN(C(C)=O)C2

$$$$
SWF002157
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342   -5.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002157

>  <SMILES>
c1ccc(CN2CC3(CC(Oc4ncccn4)CCO3)C2)nc1

$$$$
SWF002158
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  6  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 12  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002158

>  <SMILES>
CO[C@H]1CCN(C(=O)Cc2ccccn2)C[C@@H]1Cc1ccccc1

$$$$
SWF002159
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13  9  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
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 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 10 13  1  0  0  0  0
 17 21  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002159

>  <SMILES>
COc1ncc(CN2C[C@@H](C(=O)NCC3CCOCC3)C[C@H]3OCC[C@H]32)cc1C

$$$$
SWF002160
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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   -1.6728   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002160

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CN(C(=O)c1ccoc1)Cc1cn(C)nc12

$$$$
SWF002161
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002161

>  <SMILES>
O=C(CCF)N1CCC[C@@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF002162
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
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 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002162

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1C(C)C

$$$$
SWF002163
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
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 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002163

>  <SMILES>
COc1cnc(C(=O)N2CCC3(CC2)CC(N(C)C)CCO3)nc1

$$$$
SWF002164
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002164

>  <SMILES>
CO[C@H]1CO[C@@]2(CCCN(C(=O)/C=C/c3cccs3)C2)C1

$$$$
SWF002165
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002165

>  <SMILES>
O=C(C1CC1)N1CCC2(CC1)CN(Cc1ccccn1)CCO2

$$$$
SWF002166
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002166

>  <SMILES>
Cc1nnc(N2CC3(CC(OCC4CCOCC4)CS3)C2)s1

$$$$
SWF002167
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.6211    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002167

>  <SMILES>
O=C(NC[C@@H]1OC[C@H]2CN(C(=O)C3CC(O)C3)CC[C@H]21)C1CC1

$$$$
SWF002168
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.8202   -5.1517   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -6.6517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002168

>  <SMILES>
CN(C)S(=O)(=O)N1CCOC2CC(COCc3ccncc3)CC21

$$$$
SWF002169
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 22 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002169

>  <SMILES>
O=C(c1ncccn1)N1CC[C@@H](OCC2CC2)[C@@H](Cc2ccccc2)C1

$$$$
SWF002170
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 15 16  1  0  0  0  0
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 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002170

>  <SMILES>
Cn1nccc1CN1CC[C@]2(CCC[C@@H]2C(=O)NCc2cccs2)C1

$$$$
SWF002171
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    9.8726    0.1261   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002171

>  <SMILES>
O=S(=O)(C1CC1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002172
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF002172

>  <SMILES>
CN(C)C(=O)COC1CCOC2(C1)CN(Cc1cccs1)C2

$$$$
SWF002173
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3747    3.2555   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8085    2.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7452    0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2396    1.3789   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2368    1.3041   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002173

>  <SMILES>
C=CCN1CCN(C(=O)c2ccncc2)Cc2ccc(C)nc21

$$$$
SWF002174
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    1.8570   -4.5750   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6467   -2.9224   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  3  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002174

>  <SMILES>
CC(C)N(C)Cc1ncn2c1CN(C(=O)c1ccc(C#N)cc1)CCC2

$$$$
SWF002175
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002175

>  <SMILES>
C=CCN1CCN(C)C(=O)C12CCN(C(=O)c1cnccn1)C2

$$$$
SWF002176
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002176

>  <SMILES>
Cc1nc(C(=O)N2CC3(C2)OCCC3COCC2CCOCC2)cs1

$$$$
SWF002177
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.5263   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002177

>  <SMILES>
CNC(=O)CC1CN(Cc2cccc(F)c2)Cc2ccnn21

$$$$
SWF002178
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   10.3923   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  2  0  0  0  0
 13 16  1  6  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002178

>  <SMILES>
COCC1CN(Cc2ccccc2F)Cc2ncn(CC3CC3)c21

$$$$
SWF002179
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.7617    3.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
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 22 24  2  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002179

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1COC[C@H]2CN(C(=O)c3cc[nH]n3)C[C@H]21

$$$$
SWF002180
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  1  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 15 16  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002180

>  <SMILES>
O=C(NC1CCC1)[C@@H]1CO[C@@H]2CCN(C(=O)Cc3ccc(F)cn3)C[C@@H]2C1

$$$$
SWF002181
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2056    2.6562   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 12 10  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002181

>  <SMILES>
CN1CCN(C(=O)C[C@@H]2C[C@H]3CN(C(=O)C4(F)CCC4)C[C@H]3O2)CC1

$$$$
SWF002182
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002182

>  <SMILES>
O=C(C1CCC2(CCN(Cc3ccoc3)CC2)O1)N1CCCC1

$$$$
SWF002183
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002183

>  <SMILES>
CC(C)C(=O)NCCC1CN(Cc2ccco2)Cc2ccnn21

$$$$
SWF002184
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002184

>  <SMILES>
Cc1ccc(CN2C(=O)C[C@H]3[C@@H]2CCN3Cc2cccnc2)cc1

$$$$
SWF002185
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002185

>  <SMILES>
O=C(C1CCC2(CCN(Cc3ccco3)CC2)O1)N1CCCC1

$$$$
SWF002186
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002186

>  <SMILES>
Fc1ccc(CN2CC[C@@H](N3CCOCC3)[C@@H]2Cc2cccnc2)cc1F

$$$$
SWF002187
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002187

>  <SMILES>
Cc1cccc(CN2Cc3ccnn3C(CCNS(C)(=O)=O)C2)c1

$$$$
SWF002188
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    8.6537   -2.0932   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  2  0  0  0  0
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 25 26  1  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002188

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(C(=O)c4ccsc4)CC3)c3ccccc32)CC1

$$$$
SWF002189
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002189

>  <SMILES>
O=C(c1csnn1)N1C[C@H]2CN(c3ccoc3)C(=O)[C@H]2C1

$$$$
SWF002190
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 21 25  2  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 22 25  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002190

>  <SMILES>
O=C(c1cccnc1)N1CC[C@@H](OCC2CC2)[C@@H]1Cc1ccccc1

$$$$
SWF002191
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 15  1  0  0  0  0
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 21 23  1  0  0  0  0
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 12 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF002191

>  <SMILES>
O=C(C[C@@H]1CO[C@@H]2CN(Cc3cccnc3)C[C@H]12)Nc1cnccn1

$$$$
SWF002192
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    7.8615    3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    0.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
 11  7  1  6  0  0  0
 10 12  1  0  0  0  0
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 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF002192

>  <SMILES>
CC(C)NC(=O)[C@@H]1C[C@@H]2CN(C(=O)CN(C)C(C)C)C[C@@H]2C1

$$$$
SWF002193
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 14  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002193

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cc[nH]n3)CC2)CN1C(C)C

$$$$
SWF002194
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  8  7  1  1  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002194

>  <SMILES>
CN(C)C(=O)NC[C@@H]1OC[C@H]2CN(Cc3ccoc3)CC[C@H]21

$$$$
SWF002195
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1045   -4.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5827   -3.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  1  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF002195

>  <SMILES>
CN(C)C(=O)NCC1CN(Cc2ccco2)Cc2ccnn21

$$$$
SWF002196
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.5263   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1222   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -2.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 15 18  1  0  0  0  0
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 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002196

>  <SMILES>
CNC(=O)CC1CN(Cc2ccc(F)cc2)Cc2ccnn21

$$$$
SWF002197
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1045   -4.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5827   -3.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002197

>  <SMILES>
CN(C)C(=O)NCCC1CN(Cc2ccco2)Cc2ccnn21

$$$$
SWF002198
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3581    1.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6859    3.3479   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1013    1.9479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2791    4.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0794    1.7400   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9968    2.9424   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1182    4.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 10  1  0  0  0  0
 19 20  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002198

>  <SMILES>
CO[C@H]1CCN(C(=O)CCc2ccc[nH]2)[C@H]1Cc1cnn(C)c1

$$$$
SWF002199
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    6.7435   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002199

>  <SMILES>
O=C(N1CCCC1)N1CCn2c(COCc3cccnc3)nnc2C1

$$$$
SWF002200
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002200

>  <SMILES>
O=C(COC1CCCC1)N1CC[C@H]2OCC[C@@]2(COCC2CC2)C1

$$$$
SWF002201
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002201

>  <SMILES>
O=C(N1CC2(CC(Oc3cnccn3)CCO2)C1)C1(F)CCC1

$$$$
SWF002202
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002202

>  <SMILES>
CCOC1CCOC2(C1)CN(S(=O)(=O)c1ccccc1C)C2

$$$$
SWF002203
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002203

>  <SMILES>
COCCNC(=O)CC1CN(Cc2nccs2)Cc2cccn2C1

$$$$
SWF002204
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002204

>  <SMILES>
O=C(C1=CCCC1)N1C[C@H]2[C@@H](CCOc3cccnc3)CO[C@H]2C1

$$$$
SWF002205
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2554    0.9972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 14 15  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002205

>  <SMILES>
CC(=O)N1Cc2cccn2CC(CC(=O)NCc2ccco2)C1

$$$$
SWF002206
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 16 21  2  0  0  0  0
  4  7  1  0  0  0  0
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 17 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002206

>  <SMILES>
Cc1occc1C(=O)N1CC2(CC(OCC3CC3)CS2)C1

$$$$
SWF002207
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 18 20  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002207

>  <SMILES>
COCc1ccc(C(=O)N2CCc3ncnc(-c4cccnc4)c3C2)cc1

$$$$
SWF002208
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002208

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NC(C)C)C2)c1

$$$$
SWF002209
Actelion Java MolfileCreator 1.0

 29 34  0  0  0  0  0  0  0  0999 V2000
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 10  5  1  6  0  0  0
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 25 28  1  0  0  0  0
 25 29  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002209

>  <SMILES>
O=C(c1ccco1)N1CCc2nc3n(c(=O)c2C1)CCC31CCN(CC2CC2)C1

$$$$
SWF002210
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.1152   -0.2873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4461   -1.0305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7551   -1.9815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 23  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002210

>  <SMILES>
CCc1ccc(C(=O)N2CCn3c(COC)cnc3C2C)cn1

$$$$
SWF002211
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.7054    1.9487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    2.2577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7543    0.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 21 23  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002211

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccsc1)C2)N1CCCC1

$$$$
SWF002212
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7853    2.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5 10  1  0  0  0  0
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 10 15  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002212

>  <SMILES>
O=C(NC1CC1)C1CN(C(=O)c2ccccc2)C2CCOC12

$$$$
SWF002213
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 23 26  1  0  0  0  0
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 13 14  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002213

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N3CCCCC3)C2)c1

$$$$
SWF002214
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    6.6941   -1.3716   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0323   -2.8579   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.3195   -1.6990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 11  1  6  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 15 14  1  6  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002214

>  <SMILES>
CN(C)C(=O)C[C@@H]1OC[C@H]2CN(Cc3cccc(F)c3F)CC[C@H]21

$$$$
SWF002215
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   12.3007    3.1708   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   13.3044    2.0560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0872    1.0689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.7716    1.7442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    4.8107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    2.5607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8834    2.9489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002215

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)c3cc4c(s3)CCC4)C2)CN1C

$$$$
SWF002216
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.6010   -4.0293   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1001   -3.8717   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1088   -4.9919   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8538   -2.5663   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4859   -4.3788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6075   -1.2608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3794   -2.2529   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2668   -3.0282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5243   -2.4061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2207    0.1163   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5989   -0.1406   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2218   -0.7537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9927   -2.3228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7198    0.2738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9164   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6058   -0.9457   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6109   -0.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1050   -0.7881   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3055   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.7181    0.5890   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4902   -1.8501   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3762   -3.0696   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1033   -0.4730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8754   -2.9120   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   17.4885   -1.5349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.7614   -4.1315   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002216

>  <SMILES>
COCCN1CC2(CCN(C(=O)Nc3cccc(C)c3)CC2)C2(CCNC2=O)C1

$$$$
SWF002217
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.9300    2.3569   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9300    2.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300    1.4909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300    3.2229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9300    0.6248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4300    1.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4300    3.2229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300    0.6248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300    4.0889   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9300    4.0889   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4300    4.9550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300    5.8210   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9300    5.8210   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 12  1  0  0  0  0
 13 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002217

>  <SMILES>
COCCN1CCC12CCCN(C(=O)CCc1ccccc1)C2

$$$$
SWF002218
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002218

>  <SMILES>
CN(C)C(=O)NCC1CN(Cc2ccccc2)Cc2ccnn21

$$$$
SWF002219
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9218    1.9635   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3853   -1.8901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 11 14  2  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002219

>  <SMILES>
COCC1Cc2c(ncn2C)CN1C(=O)c1cnc(C)cn1

$$$$
SWF002220
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1009    1.3031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6227    1.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2054    2.2976   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0839    3.6825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
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 10  7  1  1  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002220

>  <SMILES>
CN1CC(=O)N(c2cnn(C)c2)CC12CCN(C(=O)c1ccncc1)C2

$$$$
SWF002221
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002221

>  <SMILES>
O=C(/C=C/c1cccs1)N1CCc2c(COCC3CC3)cncc2C1

$$$$
SWF002222
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002222

>  <SMILES>
Cc1ccccc1CN1Cc2ccnn2C(CCNS(=O)(=O)C2CC2)C1

$$$$
SWF002223
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  6  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002223

>  <SMILES>
Cc1noc(CC(=O)N2CCOCC3(CCN(Cc4cccs4)C3)C2)n1

$$$$
SWF002224
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  1  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002224

>  <SMILES>
COc1ccc(C(=O)N2C[C@@H]3OCCN(Cc4cccnc4)[C@@H]3C2)c(C)c1

$$$$
SWF002225
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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    6.2875    4.5181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3491    0.1438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 11 12  2  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002225

>  <SMILES>
COCCN1CCCC12CCCN(C(=O)c1ccc(C)o1)CC2

$$$$
SWF002226
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  2  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  6  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002226

>  <SMILES>
CC1(C(=O)N2CCC3(CC2)CN(Cc2nccs2)CCO3)CC=CCC1

$$$$
SWF002227
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.7204    4.2565   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7149    4.1520   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1216    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3027    4.9610   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1161    3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5338    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9406    1.5159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9187    1.3080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002227

>  <SMILES>
COCCNC(=O)C1CCCC12CCN(Cc1ccccc1F)C2

$$$$
SWF002228
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1097    2.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  1  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002228

>  <SMILES>
O=C(c1cnco1)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002229
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8367    2.4790   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 16  2  0  0  0  0
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 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002229

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(CCCN2CC(C)C)C1

$$$$
SWF002230
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4729   -8.1174   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002230

>  <SMILES>
c1cc(COCCC2CCOC23CCN(Cc2ccoc2)CC3)ccn1

$$$$
SWF002231
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1243   -4.0103   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8674   -3.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6595   -2.3630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8185   -3.6502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4026   -1.6939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7084   -2.0540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0264   -4.6283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5616   -2.9811   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1947   -0.7158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5005   -1.0759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002231

>  <SMILES>
CC(C)C(=O)N1CCC2(CC1)OCCC2CCOCc1ccccn1

$$$$
SWF002232
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0926    2.4343   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6913    3.4524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6804    3.2433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4993    1.5208   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2791    4.2614   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002232

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)CC(C)C)C2

$$$$
SWF002233
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0936   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002233

>  <SMILES>
COc1cccc(CN2CCC3(CC(Oc4cccnc4)CO3)C2)c1

$$$$
SWF002234
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -8.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002234

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CC1)CC(Nc1ncccn1)CCO2

$$$$
SWF002235
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  7  6  1  6  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002235

>  <SMILES>
COc1cccc(C(=O)N2Cc3cncn3C(CNS(C)(=O)=O)C2)c1

$$$$
SWF002236
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7173    6.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4673    5.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002236

>  <SMILES>
O=C(NCCC1CN(Cc2cccs2)Cc2ccnn21)c1ccccc1

$$$$
SWF002237
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002237

>  <SMILES>
Cc1cccc(CN2CCC23CCCN(C(=O)c2cc[nH]n2)C3)n1

$$$$
SWF002238
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 25 28  1  0  0  0  0
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 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002238

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NCc3ncccn3)C2)c1

$$$$
SWF002239
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.3923   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 10 13  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002239

>  <SMILES>
COc1cc(C(=O)N2CCC3(CCN(Cc4cccnc4)CC3)CC2)on1

$$$$
SWF002240
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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   -4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 13  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002240

>  <SMILES>
O=C(CC1CCOCC1)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002241
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF002241

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)Cn1c(-c3ccco3)cnc1CO2

$$$$
SWF002242
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002242

>  <SMILES>
Cc1cccc(CN2CCCC3(CCCN(C(=O)c4cncnc4)C3)C2)n1

$$$$
SWF002243
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  6  7  1  0  0  0  0
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  8  9  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 21 24  2  0  0  0  0
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 23 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002243

>  <SMILES>
Cc1nc(CN2CC3CN(C(=O)Cc4cccc(F)c4F)CC3C2)cs1

$$$$
SWF002244
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 21 22  2  0  0  0  0
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 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002244

>  <SMILES>
CN(C)C(=O)N1Cc2ccccc2C2(CCN(C(=O)Cc3ccccc3)CC2)C1

$$$$
SWF002245
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002245

>  <SMILES>
CC(C)(O)C(=O)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF002246
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002246

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)CN(Cc1ccccc1)CC21CCOC1

$$$$
SWF002247
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002247

>  <SMILES>
O=C(Cc1ccccn1)N1CCC2(CC1)CN(Cc1ccccc1)CC21CCOC1

$$$$
SWF002248
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002248

>  <SMILES>
Cc1cccc(CN2CCCC3(CCCN(C(=O)c4cnco4)C3)C2)n1

$$$$
SWF002249
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002249

>  <SMILES>
O=C(CNC(=O)c1ccccc1)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF002250
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    5.0034   -1.0504   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002250

>  <SMILES>
C=CCN1CCOC2CN(C(=O)c3ccc(OC)cc3C)CCC2C1

$$$$
SWF002251
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
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 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002251

>  <SMILES>
Cc1cccc(CN2CC3(CCC2=O)CCN(C(=O)c2ccccc2)CC3)n1

$$$$
SWF002252
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0468    2.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002252

>  <SMILES>
Cc1nc(CN2CCCC3(CCCN(C(=O)c4cnco4)C3)C2)cs1

$$$$
SWF002253
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 22 24  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002253

>  <SMILES>
Cc1nn(C)cc1C(=O)N1CCCC2(CCCN(CC3CC3)C2)C1

$$$$
SWF002254
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  7 10  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002254

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CC1)CN(Cc1cccnc1)CCO2

$$$$
SWF002255
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -3.2537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -9.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -9.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990  -10.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  1  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002255

>  <SMILES>
O=S(=O)(c1ccc2c(c1)CCO2)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF002256
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752    0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1045   -4.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9135   -3.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0827   -4.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6386   -5.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5827   -3.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1215   -2.1151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
  8 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002256

>  <SMILES>
Cc1noc(C)c1CN1Cc2ccnn2C(CC(=O)NC2CCC2)C1

$$$$
SWF002257
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002257

>  <SMILES>
O=C(c1cncnc1)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002258
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.5468   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5914   -3.4618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  3  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 12 16  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002258

>  <SMILES>
N#CC1(C(=O)N2CCOC3CC(COCc4cccnc4)CC32)CCCC1

$$$$
SWF002259
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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M  END
>  <HTSID>
SWF002259

>  <SMILES>
CC1CC(C(=O)N2CCOC3(CCN(Cc4ccncc4)CC3)C2)C1

$$$$
SWF002260
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002260

>  <SMILES>
O=C1N(Cc2cccnc2)Cc2ccccc2CC12CCN(c1ccncn1)CC2

$$$$
SWF002261
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002261

>  <SMILES>
O=C(NC1CCC1)C1CC12CCN(C(=O)CCc1ccc[nH]1)C2

$$$$
SWF002262
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002262

>  <SMILES>
CC(C)C(=O)N1CCCC12CCCN(Cc1cccnc1)C2

$$$$
SWF002263
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10  7  1  1  0  0  0
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M  END
>  <HTSID>
SWF002263

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(C(=O)CCc1ccc[nH]1)C2

$$$$
SWF002264
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 19 21  1  6  0  0  0
 20 22  1  0  0  0  0
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 23 24  1  0  0  0  0
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 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  9 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF002264

>  <SMILES>
Cc1ccc(OCC(=O)N2CCC3(CC2)COC(CN(C)Cc2cccnc2)C3)cc1

$$$$
SWF002265
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 13  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002265

>  <SMILES>
CN1CCC(C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)CC1

$$$$
SWF002266
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.2288   -5.0048   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002266

>  <SMILES>
c1cncc(COCCC2CCOC23CCN(Cc2cccs2)CC3)c1

$$$$
SWF002267
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
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  6 10  1  0  0  0  0
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  8 12  1  0  0  0  0
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 10 15  1  1  0  0  0
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 15 18  1  0  0  0  0
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 25 27  2  0  0  0  0
 11 16  1  0  0  0  0
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 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002267

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002268
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
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 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002268

>  <SMILES>
O=C1CCC2(CCCN(Cc3cccnc3)CC2)N1Cc1ccccc1

$$$$
SWF002269
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5341   -6.9746   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002269

>  <SMILES>
c1ccc(CN2CCC3(CC2)CN(CC2CCCO2)c2ccccc23)nc1

$$$$
SWF002270
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  6  3  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002270

>  <SMILES>
Cc1cnc(OCC2CCn3nccc3CN2C2CCC2)nc1

$$$$
SWF002271
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  6  0  0  0
 19 22  2  0  0  0  0
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 21 24  1  0  0  0  0
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 25 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002271

>  <SMILES>
C=CCOC1CC2(CCN(C(=O)c3cc[nH]n3)CC2)c2cc(C)ccc21

$$$$
SWF002272
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  2  5  1  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF002272

>  <SMILES>
Cc1ccc(CN2CCC3(CC(C(=O)N(C)C(C)C)=NO3)C2)s1

$$$$
SWF002273
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
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 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002273

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccccc3)CC2)c2ccccc21)N1CCCC1

$$$$
SWF002274
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 21 22  2  0  0  0  0
 10 13  1  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002274

>  <SMILES>
C=CCN1CCOCC2(CCN(C(=O)c3cc[nH]n3)CC2)C1

$$$$
SWF002275
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 21 25  1  0  0  0  0
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  4  7  1  0  0  0  0
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 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002275

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(C(=O)c2cc(C4CC4)on2)C3)n1

$$$$
SWF002276
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  6  0  0  0
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 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002276

>  <SMILES>
C=CCOC1CC2(CCN(C(=O)c3ccnn3C)CC2)c2cc(C)ccc21

$$$$
SWF002277
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.0283   -5.4240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 25 27  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002277

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CCC2(CC1)CC(=O)N(Cc1cccnc1)C2

$$$$
SWF002278
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002278

>  <SMILES>
COCCNC1CSC2(C1)CN(Cc1cn(C)nc1C)C2

$$$$
SWF002279
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   16.1600   -4.0095   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   14.6682   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF002279

>  <SMILES>
COCCNC(=O)c1cn2c(n1)C(C)N(C(=O)c1cc3c(s1)CCC3)CC2

$$$$
SWF002280
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  6  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002280

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)C3CCCC3)CC2)c2ccccc21)N1CCOCC1

$$$$
SWF002281
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 12 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 23 26  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002281

>  <SMILES>
O=C(NCCc1ccncc1)C1CN(C2CCOCC2)Cc2ccnn21

$$$$
SWF002282
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002282

>  <SMILES>
O=C(c1ccncc1)N1CCC2(CC1)CN(Cc1ccoc1)CCO2

$$$$
SWF002283
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002283

>  <SMILES>
Cc1cccc(CN2C(=O)C[C@@H]3[C@@H]2CCN3Cc2ccncc2)n1

$$$$
SWF002284
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 10  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002284

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CC[C@H]2[C@H]1CCN2Cc1cccnc1

$$$$
SWF002285
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -5.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002285

>  <SMILES>
Cc1cncc(C(=O)N2CCC3(CC2)CC(NS(C)(=O)=O)C3)c1

$$$$
SWF002286
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3917    0.5649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3084   -4.3385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
 12 13  1  6  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002286

>  <SMILES>
O=C([C@H]1CN(Cc2ccncc2)[C@@H]2CCO[C@H]12)N1CCOCC1

$$$$
SWF002287
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1009    1.3031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6227    1.9612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2054    2.2976   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2919    2.7044   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 10  7  1  1  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002287

>  <SMILES>
Cc1occc1C(=O)N1CCC2(C1)CN(c1cnn(C)c1)C(=O)CN2C

$$$$
SWF002288
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF002288

>  <SMILES>
CCN(CC)CCC1CN(Cc2ccccn2)Cc2ccnn21

$$$$
SWF002289
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.6394    1.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757    0.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    3.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1202    4.9127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002289

>  <SMILES>
CC(=O)NCC(=O)N1CCC2(CC1)CC(=O)N(CC1CCC1)C2

$$$$
SWF002290
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.0933   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002290

>  <SMILES>
Fc1ccc(CNCC2OCCc3cn(Cc4ccccn4)nc32)cc1

$$$$
SWF002291
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002291

>  <SMILES>
O=C(c1ccccn1)N1CCC2(CC(Nc3ncccn3)CO2)C1

$$$$
SWF002292
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002292

>  <SMILES>
CCS(=O)(=O)N1CCC(C2CCCCN2Cc2cccnc2)CC1

$$$$
SWF002293
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002293

>  <SMILES>
C[C@H]1C[C@@H]2CN(C(=O)c3ccnc(C(F)(F)F)c3)C[C@@H]2O1

$$$$
SWF002294
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002294

>  <SMILES>
CCN(CC)CCC1CN(Cc2cccc(C)n2)Cc2ccnn21

$$$$
SWF002295
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002295

>  <SMILES>
Cc1cc(CN2CC3(C2)OCCC3CCOc2ccccn2)no1

$$$$
SWF002296
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.8545    0.3295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002296

>  <SMILES>
CCc1ccc(C(=O)N2CC3(CCN(CCOC)C3)C2)cn1

$$$$
SWF002297
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002297

>  <SMILES>
CC(c1ccccc1)N1C(=O)C[C@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF002298
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002298

>  <SMILES>
c1ccc(OC2CCOC3(C2)CN(Cc2cccnc2)C3)nc1

$$$$
SWF002299
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002299

>  <SMILES>
CC(=O)N1Cc2ccccc2C(c2nccn2Cc2cccnc2)C1

$$$$
SWF002300
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002300

>  <SMILES>
Cn1cncc1CN1CCC2(CCCC2C(=O)N2CCCCO2)C1

$$$$
SWF002301
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002301

>  <SMILES>
Fc1cccnc1OCC1CCOC12CN(Cc1ccccn1)C2

$$$$
SWF002302
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002302

>  <SMILES>
O=C([C@H]1C[C@@H]2CCN(Cc3ccsc3)C[C@@H]2O1)N1CCCC1

$$$$
SWF002303
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002303

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@@H]3CN(C)CCO[C@@H]3C2)cn1

$$$$
SWF002304
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002304

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1C[C@@H]2OCCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF002305
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    8.4260   -0.6353   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.4260    0.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002305

>  <SMILES>
CC(C)CN1CC[C@@H]2CN(C(=O)c3ccnc(F)c3)C[C@@H]2CC1

$$$$
SWF002306
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002306

>  <SMILES>
Cc1cccc(CN2CC[C@]3(CCC[C@@H]3C(=O)N3CCCC3)C2)n1

$$$$
SWF002307
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 19 21  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002307

>  <SMILES>
Cn1nccc1C(=O)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002308
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.3450    1.8921   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002308

>  <SMILES>
O=C([C@H]1CCCO1)N1CCC2(CCN(c3ccsc3)C2=O)C1

$$$$
SWF002309
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF002309

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF002310
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002310

>  <SMILES>
Cc1ccsc1C(=O)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF002311
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002311

>  <SMILES>
O=C(c1ccco1)N1CCC2(C1)CN(Cc1ccccc1)c1cccnc12

$$$$
SWF002312
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
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  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
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 28 29  2  0  0  0  0
M  END
>  <HTSID>
SWF002312

>  <SMILES>
Cc1cncc(C(=O)N2CCn3cc(CC(=O)NCc4ccco4)nc3C2C)c1

$$$$
SWF002313
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
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 10 15  1  6  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002313

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1CCO[C@@H]2CCN(Cc3ccoc3)C[C@@H]21

$$$$
SWF002314
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 27 30  2  0  0  0  0
 29 31  2  0  0  0  0
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 19 21  1  0  0  0  0
 25 28  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF002314

>  <SMILES>
O=C(CC(F)(F)F)N1CCC2(CC1)Cc1ccccc1CN(Cc1ccncc1)C2=O

$$$$
SWF002315
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002315

>  <SMILES>
O=C(c1cnco1)N1C[C@@H]2OCCN(CC3CCCC3)[C@H]2C1

$$$$
SWF002316
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002316

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC(=O)N(c3ccccn3)C2)C1

$$$$
SWF002317
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    7.5812    1.0121   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.3142    0.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8481    1.6923   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2614    1.7452   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002317

>  <SMILES>
COCCC1CN(C(=O)CS(C)(=O)=O)Cc2cccn2C1

$$$$
SWF002318
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.7117    1.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3464    0.1786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3575    0.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6157   -1.6832   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 23 24  2  0  0  0  0
 10 15  1  0  0  0  0
 13 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002318

>  <SMILES>
C=CCN1CCOC2CN(C(=O)c3ccncc3OC)CCC2C1

$$$$
SWF002319
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.8281    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0360   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9871   -0.6842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8892   -1.3022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002319

>  <SMILES>
CC1CCC(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)CC1

$$$$
SWF002320
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   -0.1499    1.1118   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  1  0  0  0
 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002320

>  <SMILES>
O=C(N1C[C@@H]2OCCN(Cc3cccnc3)[C@@H]2C1)C1(F)CC1

$$$$
SWF002321
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6629    2.8653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8 11  1  0  0  0  0
 10 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002321

>  <SMILES>
CC1CC(C(=O)N2CCC3CN(C4CCOCC4)CCOC3C2)C1

$$$$
SWF002322
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  8  1  0  0  0  0
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 10 13  1  0  0  0  0
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 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002322

>  <SMILES>
COCCN1CC2(CCN(C(=O)C3CCOCC3)CC2)CC1=O

$$$$
SWF002323
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1549    2.8786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002323

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)c1nc3ccccn3c1C)C2

$$$$
SWF002324
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.8745   -6.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3913   -6.7843   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4560   -5.6116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002324

>  <SMILES>
CCc1ccc(C(=O)N2CCC3CN(CC)CCOC3C2)cn1

$$$$
SWF002325
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5364   -8.1271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  6  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002325

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(CC(C)C)C[C@@H]32)C(=O)N1CCOC

$$$$
SWF002326
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  7  1  0  0  0  0
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 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002326

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)C4CC=CC4)CC3)CC2=O)cs1

$$$$
SWF002327
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002327

>  <SMILES>
Cc1ccccc1CCC(=O)N1CC2(CC(CO)CN2C)C1

$$$$
SWF002328
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  2  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002328

>  <SMILES>
CC1c2nc(C(=O)NCc3ccco3)cn2CCN1C(=O)c1cnccn1

$$$$
SWF002329
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    7.8417   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF002329

>  <SMILES>
CNC(=O)CC1CN(Cc2ccc(C)s2)Cc2ccnn21

$$$$
SWF002330
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002330

>  <SMILES>
CNC(=O)C1CC2(CO1)CN(Cc1ccc(OC)cc1)CCO2

$$$$
SWF002331
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002331

>  <SMILES>
O=C(CC1(O)CCC1)N1CCc2ncnc(-c3cccnc3)c2C1

$$$$
SWF002332
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 19 20  2  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002332

>  <SMILES>
Cc1cc(C(=O)N2CC3(CC(OCc4ccccn4)CS3)C2)on1

$$$$
SWF002333
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.5471   -4.4801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3392   -3.5019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0823   -2.8328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7765   -2.4727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5087   -1.4328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002333

>  <SMILES>
COCCC1CCOC12CCN(C(=O)c1ccc(C)o1)CC2

$$$$
SWF002334
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 15 13  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  1  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002334

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)CCc1ccccc1F)C2

$$$$
SWF002335
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   11.1192    4.4017   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.4182    3.6517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4182    5.1517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    3.1027   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    5.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1192    6.9998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    5.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    4.4017   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    8.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    6.9998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8692    8.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  2  0  0  0  0
 10 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  2  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF002335

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCn3cc(CC(=O)NCc4ccco4)nc3C2C)cc1

$$$$
SWF002336
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5300   -2.5968   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1108   -2.9224   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1197   -1.6573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  2  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF002336

>  <SMILES>
CN(C)C(=O)NCc1ncn2c1CN(C(=O)CCc1ccc[nH]1)CCC2

$$$$
SWF002337
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    0.7679    8.3838   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0179    7.0848   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2351    8.0720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0216    5.9701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3919    6.5802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7098    4.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7168    4.0393   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8245    3.4992   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2511    3.9627   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6273    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002337

>  <SMILES>
C=CCN1C(=O)CCC12CCN(C(=O)c1ccsc1)CC2

$$$$
SWF002338
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.2342    1.0606   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002338

>  <SMILES>
O=C(NC1CC(F)(F)C1)[C@H]1CCC[C@]12CCN(Cc1ccccn1)C2

$$$$
SWF002339
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   10.2277   -5.4753   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 24 26  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002339

>  <SMILES>
O=S(=O)(C1CC1)N1CCC2(CC1)OCCC2CCOCc1cccnc1

$$$$
SWF002340
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
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 18 19  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002340

>  <SMILES>
Cc1ccc(CN2CC3(CC(OCc4ccccn4)CS3)C2)o1

$$$$
SWF002341
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002341

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)C(=O)NCC3c2ccccc2)o1

$$$$
SWF002342
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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 21 22  1  0  0  0  0
 11 15  1  0  0  0  0
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 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002342

>  <SMILES>
COCCc1cnc2n1CCN(C(=O)c1cc(C)no1)C2C

$$$$
SWF002343
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
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 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002343

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)c3ccccn3)CC2)c2ccccc21

$$$$
SWF002344
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7640   -4.6350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002344

>  <SMILES>
CC(C)N(C)CC(=O)N1CC[C@H]2CN(Cc3cccnc3)C[C@H]21

$$$$
SWF002345
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002345

>  <SMILES>
CCN1CCO[C@@H]2CN(C(=O)c3ccnc(F)c3)CC[C@@H]2C1

$$$$
SWF002346
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002346

>  <SMILES>
Cc1nn(C)cc1C(=O)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002347
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002347

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF002348
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4152   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0029   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 14 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 17 23  1  0  0  0  0
 18 24  1  0  0  0  0
 19 25  1  0  0  0  0
 20 26  1  0  0  0  0
 22 27  1  0  0  0  0
 23 28  2  0  0  0  0
 27 29  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002348

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccc(C)c(O)c1)C2

$$$$
SWF002349
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002349

>  <SMILES>
CCS(=O)(=O)NCC1CN(Cc2cccc(C)c2)Cc2ccnn21

$$$$
SWF002350
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002350

>  <SMILES>
Cc1ccc(C)c(CN2Cc3ccnn3C(CNS(C)(=O)=O)C2)c1

$$$$
SWF002351
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.9813    0.3395   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002351

>  <SMILES>
O=C(C1CC(F)C1)N1CCC2(CCc3cc(-c4ccoc4)ccc32)CC1

$$$$
SWF002352
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 12  1  0  0  0  0
  9 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002352

>  <SMILES>
O=C(C1CC(O)C1)N1CC[C@H]2CN(Cc3cccnc3)C[C@H]21

$$$$
SWF002353
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.1684   -1.8611   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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M  END
>  <HTSID>
SWF002353

>  <SMILES>
Cc1ccc(C(=O)N2CCc3ncc(CN(C)C)n3CC2)cn1

$$$$
SWF002354
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    9.0933   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF002354

>  <SMILES>
Cc1noc(C)c1CN1CCC12CCCN(C(=O)CCc1ccc(Cl)cc1)C2

$$$$
SWF002355
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF002355

>  <SMILES>
c1cncc(CN2CC3(C2)OCCC3COc2cccnc2)c1

$$$$
SWF002356
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002356

>  <SMILES>
O=C(NCc1nc(C2CCN(C(=O)C3(F)CCC3)CC2)n2ccccc12)c1ccccc1

$$$$
SWF002357
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002357

>  <SMILES>
Cn1cc(N2CC3(COCCN(Cc4ccc(F)cc4)C3)OCC2=O)cn1

$$$$
SWF002358
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002358

>  <SMILES>
O=C(c1ncc(F)cc1F)N1CCCC2(CCCN(CC3CC3)C2)C1

$$$$
SWF002359
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  6  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 12  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002359

>  <SMILES>
Cc1noc([C@H]2C[C@H]3CN(C(=O)Cc4ccccn4)CC[C@@H]3O2)n1

$$$$
SWF002360
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002360

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)COC(CN2CCC(O)C2)C3)cc1

$$$$
SWF002361
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 23 26  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002361

>  <SMILES>
Cc1nc(CN2CC[C@@H]3CN(C(=O)c4ncccc4C)C[C@@H]3CC2)cs1

$$$$
SWF002362
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
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 10 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002362

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCn3cc(CC(=O)N4CCCCC4)nc3C2C)cc1

$$$$
SWF002363
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF002363

>  <SMILES>
COCC(=O)NCCC1CN(Cc2cccs2)Cc2ccnn21

$$$$
SWF002364
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    1.5925    1.3625   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233    0.9972   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
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 10 15  1  0  0  0  0
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 12 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
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 22 24  1  0  0  0  0
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 24 26  2  0  0  0  0
 13 18  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002364

>  <SMILES>
O=C(C1=CCCCC1)N1Cc2ccnn2CCC1COc1cccnc1

$$$$
SWF002365
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 21  2  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002365

>  <SMILES>
O=C(c1cnco1)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF002366
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002366

>  <SMILES>
O=C(c1cc[nH]c1)N1CCc2ncnc(-c3ccoc3)c2CC1

$$$$
SWF002367
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8 10  1  0  0  0  0
 13 15  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002367

>  <SMILES>
CC1c2ncc(CCOc3ccncc3)n2CCN1Cc1cccnc1

$$$$
SWF002368
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  6  0  0  0
 19 20  1  0  0  0  0
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 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002368

>  <SMILES>
CCOCC1CN(C)C2(C1)CN(C(=O)c1ccc(C)cn1)C2

$$$$
SWF002369
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    8.4260    3.3647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4260    2.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5600    1.8647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2920    1.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6464    2.2715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4554    0.8702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3965    0.8702   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2056    2.2715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9773    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3747    0.6623   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6534    0.2011   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8747    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9884    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002369

>  <SMILES>
CCn1nccc1C(=O)N1C[C@H]2CCN(CCCOC)CC[C@H]2C1

$$$$
SWF002370
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002370

>  <SMILES>
Cc1noc(CC(=O)N2CCn3c(nc(CN4CCCC4)cc3=O)C2)n1

$$$$
SWF002371
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF002371

>  <SMILES>
CCN(CC)CCC1CN(C(=O)c2ccco2)Cc2ccnn21

$$$$
SWF002372
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    7.5442   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 24 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002372

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)COC(CN2CCCC(C)C2)C3)c1

$$$$
SWF002373
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF002373

>  <SMILES>
O=C(C1=CCCC1)N1Cc2cccn2CC(CCOc2ncccc2F)C1

$$$$
SWF002374
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 18 21  2  0  0  0  0
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 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002374

>  <SMILES>
CCC(=O)N1CCC(Nc2cccc(OC)c2)(C(=O)N(C)C)CC1

$$$$
SWF002375
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  2  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002375

>  <SMILES>
Cc1ccccc1CN1Cc2cccn2CC(CCOCC(=O)N(C)C)C1

$$$$
SWF002376
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002376

>  <SMILES>
CCOCC(=O)N1CC2(C1)OCCC2COc1cccnc1

$$$$
SWF002377
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.8235   -2.8009   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7745   -3.1099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002377

>  <SMILES>
CC(C)C(=O)N1CC2(C1)OCCC2COCc1ccncc1

$$$$
SWF002378
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002378

>  <SMILES>
O=C(C1CCC1)N1CC2(C1)OCCC2COc1cccnc1

$$$$
SWF002379
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.1682   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002379

>  <SMILES>
O=C(c1cnc(Cl)cc1Cl)N1CCn2c(nc(CN3CCCC3)cc2=O)C1

$$$$
SWF002380
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 24 27  2  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002380

>  <SMILES>
Cc1nc(CN2CCCC3(CCCN(C(=O)c4ccnc(F)c4)C3)C2)cs1

$$$$
SWF002381
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.4061    0.6091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002381

>  <SMILES>
c1cc(COC2C3CCC2N(Cc2ccoc2)CCO3)ccn1

$$$$
SWF002382
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9179    4.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6780    4.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8859    5.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8370    5.8951   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 13 19  1  0  0  0  0
 14 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 15 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002382

>  <SMILES>
CN(C)CCNC(=O)c1nc(-c2ccn(CCN(C)C)c2)n2ccccc12

$$$$
SWF002383
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.2634   -5.5388   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9955   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002383

>  <SMILES>
CNC(=O)C[C@@H]1C[C@H]2CN(C(=O)c3ccnc(F)c3)C[C@H]2O1

$$$$
SWF002384
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0648   -3.3653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF002384

>  <SMILES>
CCN1CCOC2CN(C(=O)CC3(OC)CCC3)CCC2C1

$$$$
SWF002385
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002385

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)COC(CN1CCC(O)C1)C2

$$$$
SWF002386
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10  7  1  1  0  0  0
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 23 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002386

>  <SMILES>
Cc1cccc(CN2Cc3ccnn3C(CNC(=O)N3CCCC3)C2)c1

$$$$
SWF002387
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002387

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ccnc(F)c3)CC2)CN1Cc1cccnc1

$$$$
SWF002388
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002388

>  <SMILES>
CC(C)CNC(=O)c1nc(-c2ccn(CCN(C)C)c2)n2ccccc12

$$$$
SWF002389
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002389

>  <SMILES>
O=C(NCc1ccccn1)[C@H]1CC[C@@H]2[C@@H](CCN2C(=O)C2CC(F)C2)O1

$$$$
SWF002390
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002390

>  <SMILES>
CN1CC(c2ccccc2)C2(CCN(C(=O)c3ccnc(F)c3)C2)C1=O

$$$$
SWF002391
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 13 17  1  0  0  0  0
 13 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 11 15  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002391

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(C1)OCCC2CCOc1ccccn1

$$$$
SWF002392
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002392

>  <SMILES>
Cc1nc(C(=O)N2CCOC(c3cn4c(N5CCOCC5)cccc4n3)C2)cs1

$$$$
SWF002393
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002393

>  <SMILES>
CCCC(=O)N1Cc2cncn2C(C(=O)NCCc2cccs2)C1

$$$$
SWF002394
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
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  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6  7  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF002394

>  <SMILES>
Cn1ccnc1CN1CCC2(COCCN(C(=O)c3ccnc(F)c3)C2)C1

$$$$
SWF002395
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 20 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002395

>  <SMILES>
Cc1cccc(CN2CC3(CC(OCc4cccnc4)CS3)C2)c1

$$$$
SWF002396
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002396

>  <SMILES>
Cn1cnc(C(=O)N2C[C@@H]3CN(Cc4ccoc4)CCO[C@@H]3C2)n1

$$$$
SWF002397
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002397

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF002398
Actelion Java MolfileCreator 1.0

 19 20  0  0  0  0  0  0  0  0999 V2000
    5.6594    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
M  END
>  <HTSID>
SWF002398

>  <SMILES>
CCSCC(=O)N1CC2(CC(NCCOC)CS2)C1

$$$$
SWF002399
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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 17 19  1  0  0  0  0
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 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002399

>  <SMILES>
Cn1cnc(C(=O)N2C[C@H]3CN(c4ccoc4)C(=O)[C@H]3C2)n1

$$$$
SWF002400
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002400

>  <SMILES>
CC(C)N(C)CC(=O)N1CCc2c(CN(C)C)cncc2C1

$$$$
SWF002401
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8185   -4.5075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6275   -5.9087   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1494   -5.2506   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6494   -6.1166   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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  9 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002401

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)C2CCOC2)C3)n1

$$$$
SWF002402
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.0333   -3.3107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.6736   -6.6213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -7.6820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002402

>  <SMILES>
O=C1CCCN1CC1CCC2(CN(C(=O)C3CCC3)C2)OC1

$$$$
SWF002403
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6119   -2.7949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2299   -2.7949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9209   -3.7459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002403

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(OCc3ccncc3)CCO2)C1

$$$$
SWF002404
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5377   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6990   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0514   -3.1283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -4.4155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3083   -3.7974   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4672   -5.0846   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5162   -4.7756   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 17 18  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002404

>  <SMILES>
O=C(c1ccnnc1)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF002405
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4456    3.4398   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9704    5.2115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1614    4.6237   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002405

>  <SMILES>
O=C(N1CC2(CC(OCC3CCOCC3)CS2)C1)C1(F)CC1

$$$$
SWF002406
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5240    2.1133   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9417    2.8178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9362    2.9223   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002406

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(C2)CN(c2cccnc2)C(=O)CN3C)o1

$$$$
SWF002407
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.7942    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2583   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF002407

>  <SMILES>
COCCNC(=O)C1CN(C(=O)c2cncc(C)c2)Cc2ccnn21

$$$$
SWF002408
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9049   -5.5314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8003   -6.5259   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF002408

>  <SMILES>
Cc1noc([C@H]2C[C@H]3CN(C(=O)c4csnn4)CC[C@H]3O2)n1

$$$$
SWF002409
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002409

>  <SMILES>
O=C(NCC1CN(Cc2ccccc2)Cc2ccnn21)N1CCCC1

$$$$
SWF002410
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.2571   -2.7121   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4650   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7218   -1.0649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4160   -1.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8263   -0.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7437   -1.2728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1592   -2.0941   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6239   -0.4468   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002410

>  <SMILES>
CC(C)C(=O)N1C[C@H]2[C@@H](CCOCc3ccccn3)CO[C@H]2C1

$$$$
SWF002411
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.2497   -4.3738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2608   -4.5229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6374   -3.7410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6485   -3.8901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9277   -5.7053   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4339   -6.2965   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002411

>  <SMILES>
Cc1ccc(C(=O)N2CCC3CN(C(C)C)CCOC3C2)o1

$$$$
SWF002412
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -4.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -5.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
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  8 11  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002412

>  <SMILES>
O=C(c1cnccn1)N1CC2(CCC(CN3CCCC3)CO2)C1

$$$$
SWF002413
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.4160   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4650   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7218   -1.0649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2571   -2.7121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8263   -0.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7437   -1.2728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3060   -3.0211   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0002   -3.3813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7923   -4.3594   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002413

>  <SMILES>
CCOCC[C@H]1CO[C@H]2CN(C(=O)c3cccc(C)c3)C[C@@H]12

$$$$
SWF002414
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3587   -6.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002414

>  <SMILES>
CSCC(=O)N1CC2(CC(Oc3cncc(C)n3)CCO2)C1

$$$$
SWF002415
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002415

>  <SMILES>
c1ccc(CN2CC3(CC(OCc4cccnc4)CS3)C2)cc1

$$$$
SWF002416
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5844   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6451   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1901   -3.3024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.4036   -1.2006   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6573   -3.6143   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4073   -2.3153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8991   -2.1585   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.7808   -3.3720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2726   -3.2152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1542   -4.4287   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.8827   -1.8449   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6460   -4.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3744   -1.6881   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.2561   -2.9016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002416

>  <SMILES>
CCCS(=O)(=O)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002417
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002417

>  <SMILES>
CCS(=O)(=O)NCC1CN(Cc2ccccc2C)Cc2ccnn21

$$$$
SWF002418
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.7942    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8543   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF002418

>  <SMILES>
COCCNC(=O)C1CN(C(=O)c2cccc(C)c2)Cc2ccnn21

$$$$
SWF002419
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002419

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF002420
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  3  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 10 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 11 16  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002420

>  <SMILES>
COCCN1CCO[C@H]2CCN(C(=O)C3(C#N)CCCC3)C[C@@H]21

$$$$
SWF002421
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1529   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.2929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002421

>  <SMILES>
Cc1ccncc1COC1CCOC2(C1)CN(C(=O)C(C)C)C2

$$$$
SWF002422
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.3115    2.1902   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.2864    1.9677   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9666    2.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5561    0.7896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9415    2.4783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2363    1.5227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  6  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF002422

>  <SMILES>
CNC(=O)CC1CN(C(=O)Cc2ccccc2F)Cc2cccn2C1

$$$$
SWF002423
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2715   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7934   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7715   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1783   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5905   -4.1321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9972   -5.0456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4094   -5.8547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3985   -6.0637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8107   -6.8727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002423

>  <SMILES>
O=C(CCF)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF002424
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.8910    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3582    2.8643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1045    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3460   -0.3882   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1082    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6000    1.4085   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2101    0.0382   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7019   -0.1186   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3120   -1.4889   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5836    1.0949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8038   -1.6457   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0754    0.9381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6855   -0.4322   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002424

>  <SMILES>
CC(C)C(=O)N1CC2(CC(OCc3ccncc3)CS2)C1

$$$$
SWF002425
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6629    2.8653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9577    3.8209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7170    3.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3944    4.6472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3972    4.7219   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0318    5.6528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0430    5.8018   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7388    6.4253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8879    5.4365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  6  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8 11  1  0  0  0  0
 10 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002425

>  <SMILES>
CC1CC(C(=O)N2CC[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)C1

$$$$
SWF002426
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5196    2.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5817    3.2040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9820    3.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5921    5.1119   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0839    5.2687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7105    6.3254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3206    7.6957   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2187    6.1686   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4389    8.9093   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3370    7.3821   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9471    8.7525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002426

>  <SMILES>
COCCNC1CSC2(C1)CN(C(=O)c1ncccc1C)C2

$$$$
SWF002427
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002427

>  <SMILES>
O=C(c1cnccn1)N1Cc2ccnn2C(C(=O)N2CCCCO2)C1

$$$$
SWF002428
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1383   -0.8004   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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 11 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002428

>  <SMILES>
CN1CC(CO)CC12CN(C(=O)c1ccc(F)c(Cl)c1)C2

$$$$
SWF002429
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4732   -5.8801   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5073   -5.6213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  9  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002429

>  <SMILES>
O=C(C1CCC1)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF002430
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.6603   -3.9553   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4422   -3.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3730   -3.6972   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2931   -2.3430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1549   -3.0737   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7077   -0.1072   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9950   -0.3653   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2452    1.5283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002430

>  <SMILES>
CC(C)CN1CCO[C@@H]2CN(C(=O)c3ccnc(F)c3)C[C@@H]2C1

$$$$
SWF002431
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0190    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002431

>  <SMILES>
Cc1cnc(C(=O)N2CC3(CCC(CNc4ncccn4)CO3)C2)cn1

$$$$
SWF002432
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002432

>  <SMILES>
CCS(=O)(=O)NCCC1CN(Cc2ccccc2C)Cc2ccnn21

$$$$
SWF002433
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9931    0.3236   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4518    0.8638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3049    1.7909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7636    2.3310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1902    2.7945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5021    4.2618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3874    5.2655   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6992    6.7327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002433

>  <SMILES>
COCCC1CCOC12CCN(Cc1ccc(C)cc1)CC2

$$$$
SWF002434
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.9273    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9055    1.9095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7364    0.3004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4055    1.0435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4000    0.9390   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9878    1.7480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9823    1.6435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5811    2.6615   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5701    2.4525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5865    2.7661   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1689    3.4706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1634    3.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002434

>  <SMILES>
CN(C)C(=O)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF002435
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822   -0.1727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1645   -4.3601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9510   -2.2582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1682   -3.2454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4182   -1.9463   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002435

>  <SMILES>
CN(C)C(=O)C1(Nc2ccnn2C)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF002436
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    8.6449    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1449    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6449    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1449    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1449    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6449    2.0685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6449    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6449    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <HTSID>
SWF002436

>  <SMILES>
COCCNC(=O)Cc1cn2c(n1)C(C)N(C(=O)COC)CC2

$$$$
SWF002437
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6426    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4836    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8994    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7405    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9484    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2052    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2542    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4451    3.2807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0549    1.7418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002437

>  <SMILES>
CCOCCC1CCOC12CCN(Cc1cnn(C)c1)CC2

$$$$
SWF002438
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8424    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5856    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2798    0.5248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7445    2.1720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2308    0.8338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6956    2.4811   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9590   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4387    1.8119   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3603   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 20 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002438

>  <SMILES>
CN1CCC2(CC1)CC(COCC1CC1)N(C(=O)c1ccccc1)C2

$$$$
SWF002439
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    3.0020   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    3.0020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    3.9531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3581    2.6930   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5158    4.6575   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7  9  1  0  0  0  0
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  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  6  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002439

>  <SMILES>
Cc1ccc(OCC(=O)N2CC3(CC(CO)CN3C)C2)cc1

$$$$
SWF002440
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    7.8655    0.8899   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4020   -0.5367   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692   -0.2248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    4.7302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    3.0613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6483    4.1065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1118    5.5331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  6  8  2  0  0  0  0
 15 20  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF002440

>  <SMILES>
O=C(Cc1ccco1)N1CCC2(CC1)c1ccccc1N(CC1CC1)S2(=O)=O

$$$$
SWF002441
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  8  6  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002441

>  <SMILES>
O=C1CCCN1CC1CCC2(CN(C(=O)c3cnccn3)C2)OC1

$$$$
SWF002442
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.9128    3.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    2.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    3.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    5.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002442

>  <SMILES>
COCC1CN(C(=O)c2csc(C)n2)Cc2cn(C)nc21

$$$$
SWF002443
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2715   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7934   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7715   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1783   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002443

>  <SMILES>
CCCC(=O)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002444
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889   -0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1280   -2.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002444

>  <SMILES>
Cc1ccncc1COC1CCOC2(C1)CN(C(=O)C1CCC1)C2

$$$$
SWF002445
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0327   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0109   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5109   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0932   -1.5409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002445

>  <SMILES>
CCOCC1CN(C(=O)c2cc(C(C)=O)[nH]n2)Cc2cn(C)nc21

$$$$
SWF002446
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1206   -1.3440   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0955   -1.5666   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002446

>  <SMILES>
COCCC1CN(C(=O)COc2ccc(C)cc2)Cc2cccn2C1

$$$$
SWF002447
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002447

>  <SMILES>
CCc1ccc(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)cn1

$$$$
SWF002448
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002448

>  <SMILES>
CNC(=O)CC1CC2(CCN(CC3CCOCC3)CC2)c2ccccc21

$$$$
SWF002449
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    8.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6400   -3.4820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 26 28  2  0  0  0  0
 14 10  1  1  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002449

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1C[C@@H]2CCN(C(=O)c3ncn(C)n3)C[C@@H]2O1

$$$$
SWF002450
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889    3.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3902    3.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 10 12  2  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002450

>  <SMILES>
Cn1cnc2c1CC(CO)N(C(=O)COc1ccccc1)C2

$$$$
SWF002451
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.8910    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3582    2.8643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1045    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1082    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6000    1.4085   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2101    0.0382   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7019   -0.1186   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.3120   -1.4889   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002451

>  <SMILES>
CC(C)C(=O)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF002452
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 25 27  2  0  0  0  0
 12 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002452

>  <SMILES>
COCc1ccc(C(=O)N2CCc3ncc(-c4ccccc4)n3CC2)cc1

$$$$
SWF002453
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
   15.6894   -8.3083   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.3903   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3903   -6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0913   -8.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0913   -5.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -5.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -3.0583   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -3.0583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 13  1  6  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002453

>  <SMILES>
CN(C)C(=O)C[C@@H]1C[C@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]2O1

$$$$
SWF002454
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002454

>  <SMILES>
CC1CC(C(=O)N2CCC3(C2)CN(c2cccnc2)C(=O)CN3C)C1

$$$$
SWF002455
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    2.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321    0.6340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812    1.3090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  2  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002455

>  <SMILES>
Cn1cnc2c1CC(CNc1ncccn1)N(S(C)(=O)=O)C2

$$$$
SWF002456
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6402   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002456

>  <SMILES>
Cc1cc(N2CCO[C@H]3CN(Cc4scnc4C)C[C@@H]32)ccn1

$$$$
SWF002457
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.2864    1.9677   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5561    0.7896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1958   -0.6765   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8509   -0.1659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1707   -0.8990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 18  1  6  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7 10  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF002457

>  <SMILES>
COCCC1CN(C(=O)c2ccccc2F)Cc2cccn2C1

$$$$
SWF002458
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4746    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0981    3.1906   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5384    2.7602   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5472    4.0252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0318    1.3877   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0067    1.6103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6213    3.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3015    2.5658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 12 15  1  0  0  0  0
 16 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002458

>  <SMILES>
CC(C)CC(=O)N1Cc2cccn2CC(OCc2ccccn2)C1

$$$$
SWF002459
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  1  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002459

>  <SMILES>
CSCC(=O)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF002460
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002460

>  <SMILES>
Cc1nnc(C2CN(C)C(=O)[C@H]3CCN(C(=O)CC4(O)CCC4)CC[C@@H]23)o1

$$$$
SWF002461
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002461

>  <SMILES>
COCC1CC2(CCN(C(=O)c3ncn(C)n3)CC2)CN1C

$$$$
SWF002462
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002462

>  <SMILES>
CSCC(=O)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF002463
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002463

>  <SMILES>
O=C(C1CC(O)C1)N1C[C@@H]2CCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF002464
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002464

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF002465
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 21 24  2  0  0  0  0
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 23 26  1  0  0  0  0
 23 27  1  0  0  0  0
 25 28  1  0  0  0  0
 25 29  1  0  0  0  0
 26 30  1  0  0  0  0
 27 31  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 28 29  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF002465

>  <SMILES>
O=C(Nc1ccc(C(=O)N2CCCC3(CCN3CC(=O)N3CCCC3)C2)cc1)C1CC1

$$$$
SWF002466
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4915    3.5446   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3825    2.0014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2637    3.3584   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6720   -1.4781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  3  0  0  0  0
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 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  1  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002466

>  <SMILES>
COCC1CN(C(=O)C2(C#N)CCCC2)Cc2cn(C)nc21

$$$$
SWF002467
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.2869   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1529   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002467

>  <SMILES>
CCCC(=O)N1CC2(C1)CN(CC1CC1)C(C(=O)NC)CO2

$$$$
SWF002468
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 22 23  1  0  0  0  0
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 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 16 17  2  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002468

>  <SMILES>
O=C(NCc1ccco1)c1ncn2c1CN(C(=O)CC1(O)CCC1)CCC2

$$$$
SWF002469
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002469

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)C2CCC2)C3)n1

$$$$
SWF002470
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002470

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)o1

$$$$
SWF002471
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10  9  1  1  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002471

>  <SMILES>
CCCNC(=O)C1=NOC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF002472
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1783   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002472

>  <SMILES>
O=C(CCF)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002473
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
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 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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  6  8  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002473

>  <SMILES>
CSCC(=O)N1CC2(CC(Oc3cccnc3)CS2)C1

$$$$
SWF002474
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
  6  7  1  0  0  0  0
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 19 23  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF002474

>  <SMILES>
Cn1cncc1CN1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF002475
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.7562   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 22 25  1  0  0  0  0
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 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002475

>  <SMILES>
COC1CC2(CCN(C(=O)c3ccc(C)o3)CC2)c2cc(C)ccc21

$$$$
SWF002476
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0032    1.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.1051    0.2537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002476

>  <SMILES>
C=CCOc1ccc(C(=O)N2CC[C@@H]3O[C@@H](C)C[C@H]3C2)cc1

$$$$
SWF002477
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    0.5920    5.2023   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0042    4.3933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9903    4.4978   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4110    3.4797   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5781    3.6888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1713    2.7752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7591    1.9662   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  8  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002477

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)c1cc(F)ncc1F)C2

$$$$
SWF002478
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   12.7103    3.4072   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7139    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4967    1.3053   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9639    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3820    0.3016   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    5.0471   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3715    3.4072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5851    1.3053   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002478

>  <SMILES>
CC(C)CN1CC[C@@H]2CN(C(=O)c3sccc3F)C[C@@H]2CC1

$$$$
SWF002479
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8745   -6.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3913   -6.7843   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4560   -5.6116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8433   -8.1806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
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  9 14  1  6  0  0  0
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 11 16  2  0  0  0  0
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 15 18  1  6  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002479

>  <SMILES>
CCN1CCO[C@@H]2CN(C(=O)c3ccccc3C)CC[C@@H]2C1

$$$$
SWF002480
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 12  1  0  0  0  0
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 14 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002480

>  <SMILES>
CC1CC(C(=O)N2C[C@H](OCc3cccnc3)[C@H]3OCCC[C@H]32)C1

$$$$
SWF002481
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.3433   -6.8083   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8433   -6.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8797   -5.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3068   -5.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7249   -8.0218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002481

>  <SMILES>
COCc1cncc2c1CCN(C(=O)c1csc(C)n1)C2

$$$$
SWF002482
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
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 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002482

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)Cn1c(-c3cccnc3)cnc1CO2

$$$$
SWF002483
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.4490   -2.9888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  4  7  1  6  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002483

>  <SMILES>
c1cncc(CN2CCO[C@@H]3CN(CC4CC4)CC[C@@H]3C2)c1

$$$$
SWF002484
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.9476   -4.2822   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 12  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002484

>  <SMILES>
COCC(=O)N1C[C@@H]2CN(C(=O)c3ccccc3)CCO[C@@H]2C1

$$$$
SWF002485
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
    9.5479   -5.6289   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10  7  1  6  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 12 14  1  1  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
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 21 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002485

>  <SMILES>
O=C1N(c2ccsc2)CC[C@]12CN(CC1CCCCC1)C[C@H]2c1ccccc1

$$$$
SWF002486
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 13  1  0  0  0  0
 14 15  2  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002486

>  <SMILES>
Cc1noc(CC(=O)N2CCc3ncnc(-c4cccnc4)c3C2)n1

$$$$
SWF002487
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002487

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC[C@@H]3CN(C)CCO[C@@H]3C2)n[nH]1

$$$$
SWF002488
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002488

>  <SMILES>
COCc1ccc(C(=O)N2CCC3(CC2)CC(N(C)C)CCO3)cc1

$$$$
SWF002489
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002489

>  <SMILES>
O=C(c1ccsc1)N1CC2CN(CC3CCCCC3)CC2C1

$$$$
SWF002490
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 24 26  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002490

>  <SMILES>
O=C(c1cccs1)N1Cc2cccn2CC(CCNc2ccccn2)C1

$$$$
SWF002491
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002491

>  <SMILES>
COCC(=O)N1CC2(CC(CCOc3cncc(C)n3)CCO2)C1

$$$$
SWF002492
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002492

>  <SMILES>
Cc1ccoc1C(=O)N1CC2(CCC(CN3CCCC3=O)CO2)C1

$$$$
SWF002493
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  2  0  0  0  0
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 18 20  1  0  0  0  0
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 22 23  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002493

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CCC(=O)N(Cc3ccncc3)C2)CC1

$$$$
SWF002494
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  8  9  1  0  0  0  0
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 12 11  1  1  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 19 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002494

>  <SMILES>
COC[C@H]1CC[C@@H]2[C@@H](CCN2C(=O)Cc2ccc(F)cn2)O1

$$$$
SWF002495
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    7.8615   -0.9612   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002495

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)c3ccnc(F)c3)C[C@H]2N1C(C)C

$$$$
SWF002496
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.5442   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  1  1  0  0  0
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 12 14  1  0  0  0  0
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 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002496

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)COC(CN2CCC[C@H]2CO)C3)c1

$$$$
SWF002497
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  1  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 16 20  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002497

>  <SMILES>
CCCC(=O)N1CCn2cc(C(=O)NCc3ccccn3)nc2C1C

$$$$
SWF002498
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3301    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    4.2709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301    5.1369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3301    5.1369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7423    5.9459   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7913    4.6369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002498

>  <SMILES>
COC[C@H](C)NC(=O)c1nc2c(o1)CCN(C(=O)C1CCCO1)C2

$$$$
SWF002499
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1027    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002499

>  <SMILES>
O=C(NCC1OCCc2cn(Cc3ccccc3)nc21)c1cccc(O)c1

$$$$
SWF002500
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 14  1  6  0  0  0
 17 15  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002500

>  <SMILES>
COCC1CN(C)C(=O)[C@H]2CCN(C(=O)Cc3ccc(F)cn3)CC[C@@H]12

$$$$
SWF002501
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846   -3.1317   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002501

>  <SMILES>
O=C(NC1CC1)C1C[C@@H]2CCN(C(=O)C3CC(O)C3)C[C@@H]2O1

$$$$
SWF002502
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.6027    4.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
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 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 11 15  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002502

>  <SMILES>
COc1ccc(C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)c(OC)c1

$$$$
SWF002503
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   11.1950   -1.9318   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.2004   -2.0363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6127   -1.2273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7992   -3.0544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002503

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cccc(F)c3)CC2)CC1=O

$$$$
SWF002504
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.7215    0.0771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
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  3  7  1  0  0  0  0
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  8 11  1  6  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002504

>  <SMILES>
c1ccc(N[C@H]2CCO[C@]3(CCN(Cc4cccnc4)C3)C2)nc1

$$$$
SWF002505
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002505

>  <SMILES>
O=C(c1cc[nH]c1)N1C[C@H](OCc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF002506
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3412   -3.6691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0823   -6.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002506

>  <SMILES>
CCn1cc(CN2C[C@@H](C(=O)N(C)C)C[C@H]3OCC[C@H]32)cn1

$$$$
SWF002507
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 26  2  0  0  0  0
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 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002507

>  <SMILES>
C=CCN1c2cccnc2-n2cccc2C12CCN(C(=O)CC(C)C)C2

$$$$
SWF002508
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3850   -2.4544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8208   -1.1153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1907   -3.2721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002508

>  <SMILES>
O=C1CCC2(CCCN(Cc3cccnc3)CC2)N1CCF

$$$$
SWF002509
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002509

>  <SMILES>
Cc1noc(C2CCC3(CCN(C(=O)/C=C/c4cccs4)CC3)O2)n1

$$$$
SWF002510
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7820   -4.6894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002510

>  <SMILES>
Cc1csc(C(=O)N2C[C@@H]3CN(CC4CC4)CCO[C@@H]3C2)c1

$$$$
SWF002511
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    9.0950    2.9345   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.0950    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3879    3.6416   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3879    2.2274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002511

>  <SMILES>
O=C(NC1CC1)C1C[C@@H]2CCN(C(=O)C3CC(F)C3)C[C@@H]2O1

$$$$
SWF002512
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9002   -2.4653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5463   -1.7323   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002512

>  <SMILES>
COCCN1CC2(COCCN(Cc3ccc(OC)cc3)C2)CC1=O

$$$$
SWF002513
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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  4  7  1  1  0  0  0
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  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
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 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002513

>  <SMILES>
c1ccc(CN2CCO[C@H]3[C@H](OCc4ccncc4)CC[C@@H]32)nc1

$$$$
SWF002514
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002514

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cccc(F)c3)CC2)CN1CC1CC1

$$$$
SWF002515
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 17 15  1  1  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002515

>  <SMILES>
Cc1nc([C@H]2C[C@@H]3CCN(C(=O)Cc4ccc(F)cn4)C[C@H]3O2)no1

$$$$
SWF002516
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.4368   -0.3750   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0301   -1.2885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002516

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)c1c(C)cccc1F)C2

$$$$
SWF002517
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002517

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccnn3C)CC2)CC1COC

$$$$
SWF002518
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
    8.5346   -1.4546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF002518

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCC3(CCc4nnc(C(=O)NC5CCCC5)n4CC3)C2)c1

$$$$
SWF002519
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
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  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002519

>  <SMILES>
C=CCN1C(=O)CO[C@@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]21

$$$$
SWF002520
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
 10  8  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
  4  6  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002520

>  <SMILES>
Cc1cccc(C(=O)N2Cc3cncn3C(C(=O)NCc3cccs3)C2)c1

$$$$
SWF002521
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  8  6  1  6  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  5  7  1  0  0  0  0
 11 13  1  6  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002521

>  <SMILES>
Cc1cccc(C(=O)N2C[C@@H]3[C@H](CN4CCCC4=O)CO[C@@H]3C2)c1

$$$$
SWF002522
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8824    3.7089   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  2  0  0  0  0
 25 29  1  0  0  0  0
 26 30  1  0  0  0  0
 30 31  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 27 28  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002522

>  <SMILES>
CN1Cc2cccc(-c3cnc4n3CCN(C(=O)c3ccc(N(C)C)cc3)CC4)c2C1

$$$$
SWF002523
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    9.0619   -1.0978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  2  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002523

>  <SMILES>
O=C1CC[C@@H](C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)N1

$$$$
SWF002524
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  6  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002524

>  <SMILES>
Cc1nc(CO[C@@H]2CCN(C(=O)C3CC(O)C3)C[C@H]2Cc2ccccc2)cs1

$$$$
SWF002525
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002525

>  <SMILES>
C[C@@H](O)C(=O)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF002526
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1141   -2.8752   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.0208   -4.6548   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002526

>  <SMILES>
Cc1noc([C@@H]2C[C@H]3CN(C(=O)Cc4ccc(F)cn4)C[C@H]3O2)n1

$$$$
SWF002527
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.8734    1.7633   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8118    3.2758   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7659    2.9761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002527

>  <SMILES>
O=C(N1CCOC2CCC1C2OCc1ccncc1)C1(F)CC1

$$$$
SWF002528
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    7.4951    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9073    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
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 14 18  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002528

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1C[C@H](OCCCn2cccn2)[C@H]2OCCC[C@H]21

$$$$
SWF002529
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.7539   -1.5435   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0468    0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002529

>  <SMILES>
O=C(NCC1CC1)C1C[C@@H]2CCN(C(=O)C3(F)CC3)C[C@@H]2O1

$$$$
SWF002530
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002530

>  <SMILES>
CN1C[C@H](COCc2cccnc2)[C@]2(CCN(C(=O)/C=C/c3cccs3)C2)C1

$$$$
SWF002531
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6939   -2.3647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
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  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002531

>  <SMILES>
O=C(c1cncnc1)N1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF002532
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002532

>  <SMILES>
Cc1cc(C)nc(N2CCOC3(COC(C(=O)N(C)C)C3)C2)n1

$$$$
SWF002533
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 18 20  1  1  0  0  0
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 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002533

>  <SMILES>
CN(C)C1CCOC2(CCN(C(=O)C3CC(F)(F)C3)CC2)C1

$$$$
SWF002534
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002534

>  <SMILES>
O=C1CCC2(CCCN(Cc3ccncc3)CC2)N1Cc1ccccc1

$$$$
SWF002535
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
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 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
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 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002535

>  <SMILES>
COc1ccccc1-c1cnc2n1CCN(C(=O)c1ccc(N(C)C)cc1)CC2

$$$$
SWF002536
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.3910    2.2121   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002536

>  <SMILES>
COCCN1CC[C@@H]2CN(C(=O)c3cc(C)cc(C)c3)C[C@@H]21

$$$$
SWF002537
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6  8  1  0  0  0  0
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  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002537

>  <SMILES>
Cc1noc(C)c1C(=O)N1CCC2(CC1)CC(=O)N(CC1CC1)C2

$$$$
SWF002538
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
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 17 19  1  6  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 15 10  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002538

>  <SMILES>
Cc1ccccc1C(=O)N1CC[C@H]2C[C@H](C(=O)N3CCCC3)O[C@@H]2C1

$$$$
SWF002539
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9773    2.6181   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4337    3.1029   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002539

>  <SMILES>
Cn1cnc(C(=O)N2CCOC3CCC2C3OCc2ccncc2)n1

$$$$
SWF002540
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002540

>  <SMILES>
CCn1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N(C)C)C2)cn1

$$$$
SWF002541
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.7577   -2.9383   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002541

>  <SMILES>
CC(C)=CC(=O)N1CCCC2(CC1)CCN(Cc1cccnc1)C2=O

$$$$
SWF002542
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    6.1962    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  6  7  1  0  0  0  0
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 19 17  1  1  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002542

>  <SMILES>
O=C(C1CC1c1ccc(Cl)cc1)N1CC[C@H]2CC(CN3CCCOCC3)O[C@H]2C1

$$$$
SWF002543
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002543

>  <SMILES>
CS(=O)(=O)N1CC2(CCN(Cc3ccncc3)C2)c2ncccc21

$$$$
SWF002544
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.6277   -3.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6277   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 15 19  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002544

>  <SMILES>
COCCN1CCO[C@H]2CN(C(=O)Cc3ccccn3)C[C@H]21

$$$$
SWF002545
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7402   -2.4999   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6537   -2.0932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5492   -1.0986   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002545

>  <SMILES>
COCC1CC2(CCN(C(=O)c3csc(C)n3)CC2)CN1C

$$$$
SWF002546
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
   -0.9788   -5.1731   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9788   -6.6731   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  1  0  0  0
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 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002546

>  <SMILES>
COCCN1CCO[C@H]2CN(C(=O)C3CC(F)(F)C3)C[C@H]21

$$$$
SWF002547
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 13 18  1  0  0  0  0
 16 19  2  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002547

>  <SMILES>
Cn1cnc(C2CN(C(=O)c3ccco3)CC23CCN(CC2CC2)C3=O)c1

$$$$
SWF002548
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6551   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
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 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002548

>  <SMILES>
CC(C)N(C)CC(=O)N1CC[C@H]2[C@H]1CCN2Cc1cccnc1

$$$$
SWF002549
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002549

>  <SMILES>
Cc1nnc2n1C1(CCN(Cc3ccccc3F)CC1)CN(C)C2

$$$$
SWF002550
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002550

>  <SMILES>
CN(C)C1CCOC2(CCN(C(=O)CC3(O)CCC3)CC2)C1

$$$$
SWF002551
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.8295    1.3993   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002551

>  <SMILES>
O=C(N1C[C@H](OCc2ccncc2)[C@H]2OCCC[C@H]21)C1(F)CC1

$$$$
SWF002552
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.7816    0.1488   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4726   -0.8023   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  2  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002552

>  <SMILES>
O=C(c1ccoc1)N1CCn2c(-c3cccc(F)c3)cnc2C1

$$$$
SWF002553
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002553

>  <SMILES>
CC(C)/C=C/C(=O)N1C[C@H]2CCN(CC(=O)N(C)C)CC[C@H]2C1

$$$$
SWF002554
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
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 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 18 23  2  0  0  0  0
 20 24  2  0  0  0  0
  6  9  1  0  0  0  0
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 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002554

>  <SMILES>
Cc1ccccc1CN1CC2(CC(Oc3ncccn3)CCO2)C1

$$$$
SWF002555
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9159    2.7624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5666    3.1862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4531    3.6489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  9 13  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 12  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002555

>  <SMILES>
CC1CC(C(=O)N2CCOC3CCC2C3OCc2cccnc2)C1

$$$$
SWF002556
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002556

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2ccncc2)N1Cc1ccccc1

$$$$
SWF002557
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9704    5.2115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
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 10 12  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002557

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF002558
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2314    5.2046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0872    4.3734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2437    5.3611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002558

>  <SMILES>
O=C(C1CCC1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF002559
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8338    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8412   -0.9427   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3011    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2341   -3.9240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3048    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7259   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0644   -8.0349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5562   -8.1917   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002559

>  <SMILES>
O=C(CCF)N1C[C@H](OCc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF002560
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9159    2.7624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5666    3.1862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002560

>  <SMILES>
O=C(C1CC(O)C1)N1CCOC2CCC1C2OCc1ccncc1

$$$$
SWF002561
Actelion Java MolfileCreator 1.0

 30 35  0  0  0  0  0  0  0  0999 V2000
    6.8202   -6.6517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 27 30  1  0  0  0  0
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 10 11  1  0  0  0  0
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 19 21  1  0  0  0  0
 26 28  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002561

>  <SMILES>
O=c1c2c(nc3n1CC1(CCN(CC4CC4)CC1)C3)CCN(Cc1cccnc1)C2

$$$$
SWF002562
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002562

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(C(=O)C(C)C)C3)n1

$$$$
SWF002563
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002563

>  <SMILES>
COCC1CCS(=O)(=O)C12CN(C(=O)c1ccncc1)C2

$$$$
SWF002564
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 23 25  2  0  0  0  0
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 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002564

>  <SMILES>
CN1CCC(COCc2ccccn2)CC12CN(S(=O)(=O)N(C)C)C2

$$$$
SWF002565
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  6  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002565

>  <SMILES>
CN(C)CC1CCCc2nc3c(c(=O)n21)CN(C(=O)c1cccs1)CC3

$$$$
SWF002566
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3955   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002566

>  <SMILES>
CCC(C)N1C[C@@H]2[C@H](NC(=O)C(C)(C)C)c3ccccc3[C@@H]2C1

$$$$
SWF002567
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5583   -0.9367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002567

>  <SMILES>
N#CCN1CCOCC2(CCN(C(=O)C3(F)CCC3)CC2)C1

$$$$
SWF002568
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002568

>  <SMILES>
CO[C@H]1CCN(C(=O)N2CCCC2)C[C@@H]1Cc1ccccc1

$$$$
SWF002569
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  2  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002569

>  <SMILES>
COCc1cncc2c1CCN(C(=O)c1ccc(OC)cc1C)C2

$$$$
SWF002570
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002570

>  <SMILES>
CO[C@H]1CCN(C(=O)N2CCCC2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF002571
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  1  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002571

>  <SMILES>
O=C1CCC2(CCN(C(=O)C3CCOC3)CC2)CN1Cc1cccnc1

$$$$
SWF002572
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7562   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002572

>  <SMILES>
O=C(C1=CCCC1)N1CCC2(CC1)CC(Oc1cccnc1)CO2

$$$$
SWF002573
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1792   -5.2521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4882   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9590   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8702   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  6  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002573

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)c3ccco3)CC2)c2ccccc21

$$$$
SWF002574
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002574

>  <SMILES>
O=C(c1ncccn1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF002575
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.7539   -1.5435   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0468    0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 13 11  1  6  0  0  0
 14 15  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002575

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1C[C@H]2CCN(C(=O)C3(F)CC3)C[C@@H]2O1

$$$$
SWF002576
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.9010    3.9431   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
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 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002576

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(CCc1ccccc1)C2

$$$$
SWF002577
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
 10 12  2  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002577

>  <SMILES>
Cn1nccc1C(=O)N1CC2(CC(OCC3CC3)CCO2)C1

$$$$
SWF002578
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002578

>  <SMILES>
CC1c2nc(C(=O)NCc3cccs3)cn2CCN1C1CCC1

$$$$
SWF002579
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.0749    4.2169   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 11 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF002579

>  <SMILES>
CCc1ccc(C(=O)N2CC3(CCN(CC(C)C)C3)C2)cn1

$$$$
SWF002580
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
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   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 21 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
M  END
>  <HTSID>
SWF002580

>  <SMILES>
COCCN1CCCC2(CCN(C(=O)CN(C)C(C)C)CC2)C1=O

$$$$
SWF002581
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF002581

>  <SMILES>
CNC(=O)CC1CN(C(=O)c2cccc(C)c2)Cc2ccnn21

$$$$
SWF002582
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002582

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(=O)N(Cc2cccnc2)C3)C1

$$$$
SWF002583
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.7221   -5.1517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4721   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -6.4508   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002583

>  <SMILES>
c1cnc(N2CC[C@@H]3CN(CC4CCCCC4)C[C@@H]3C2)nc1

$$$$
SWF002584
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.4098   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0031   -1.2522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5031   -0.3862   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  1  0  0  0
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  8 12  1  0  0  0  0
  8 13  1  6  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  6  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002584

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(CCOC)C[C@@H]32)C(=O)N1CC(C)C

$$$$
SWF002585
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.9128    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4347    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 11 10  1  1  0  0  0
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002585

>  <SMILES>
Cc1nc(COCCC2CCOC23CCN(C(=O)N(C)C)CC3)cs1

$$$$
SWF002586
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.4890   -4.2071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002586

>  <SMILES>
Cn1nnc2c1C(COCC1CC1)CN(C(=O)C1(F)CC1)C2

$$$$
SWF002587
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.2277   -5.4753   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF002587

>  <SMILES>
O=C(c1ncccn1)N1CCC2(CC1)OCCC2CCOCC1CC1

$$$$
SWF002588
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002588

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2COC[C@]2(COCC2CCOCC2)C1

$$$$
SWF002589
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002589

>  <SMILES>
O=C1CC[C@@H]2[C@@H](CCN2Cc2ccncc2)N1c1ccccc1

$$$$
SWF002590
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
   11.8872   -1.7878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
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 13 14  1  0  0  0  0
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 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF002590

>  <SMILES>
CCN1CCC2(CN(CC(C)C)CC23CCN(C(=O)COc2ccccc2)CC3)C1=O

$$$$
SWF002591
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 18 20  2  0  0  0  0
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  4  7  1  0  0  0  0
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 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002591

>  <SMILES>
Cc1cccc(CN2CC3(CC(OCC4CC4)CS3)C2)n1

$$$$
SWF002592
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8147    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002592

>  <SMILES>
CCn1cc(CN2CCC3(CC(n4ccnc4)CO3)C2)cn1

$$$$
SWF002593
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
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  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF002593

>  <SMILES>
O=C(CCc1ccc[nH]1)Nc1ccc2c(c1)C1(CCOCC1)C(=O)N2c1ccsc1

$$$$
SWF002594
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002594

>  <SMILES>
C[C@@H]1CN(C(=O)Cc2cccc(F)c2)C[C@]12CCN(C)C2=O

$$$$
SWF002595
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002595

>  <SMILES>
COCC(=O)N1C[C@@H]2COC[C@]2(COCc2cccnc2)C1

$$$$
SWF002596
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 11 15  1  0  0  0  0
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 14 16  1  6  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002596

>  <SMILES>
O=C(N[C@@H]1C[C@H]2C[C@@H]1CN2Cc1cccnc1)[C@H]1[C@@H]2COC[C@@H]21

$$$$
SWF002597
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4019    1.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0981    0.8068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9019    0.8068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002597

>  <SMILES>
CC(C)NC(=O)[C@H]1C[C@@H]2[C@@H](C1)OCCN2Cc1ccccn1

$$$$
SWF002598
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
   10.3737   -2.0035   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1898   -1.5159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1898    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8770   -2.2739   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5027    0.7580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8770    0.7580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1898   -3.0319   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8770   -0.7580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5642   -3.0319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3483   -4.5395   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6405   -2.5500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5642    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2513   -2.2739   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8311   -4.8547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5891   -3.5418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2513   -0.7580   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9385   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9385    1.5159   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3128    1.5159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF002598

>  <SMILES>
CN(C)CC(=O)N1CCC(C(=O)N(C)C)(n2cccn2)CC1

$$$$
SWF002599
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.4358    7.4773   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9358    6.6113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    5.7452   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9358    6.6113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9358    4.8792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4358    5.7452   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    4.0132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9358    4.8792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4358    4.0132   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9358    3.1472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9330    3.2219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3724    2.3209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6131    2.4888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  5  8  2  0  0  0  0
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  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002599

>  <SMILES>
C=CCN1CCOC2CCN(C(=O)c3cccc(Cl)c3)CCC21

$$$$
SWF002600
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6456   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002600

>  <SMILES>
O=C1CCC2(CCN(Cc3ccc(F)c(F)c3)CC2)N1CC1CC1

$$$$
SWF002601
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.9955   -5.5388   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2634   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3974   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7071   -1.2071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002601

>  <SMILES>
O=C(N1CC2CN(Cc3cccc(F)c3)CC2C1)C1(F)CC1

$$$$
SWF002602
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002602

>  <SMILES>
CCC(=O)N1CCCC(Nc2ccccc2)(C(=O)N(C)C)C1

$$$$
SWF002603
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002603

>  <SMILES>
CN1C(=O)CCCC12CCCN(Cc1ccc(F)c(F)c1)C2

$$$$
SWF002604
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.4445    5.7715   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8710    5.3080   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5592    6.7752   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9810    4.3450   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4408    6.8863   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9847    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5137    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9736    6.5744   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0502    2.6065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9006    9.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  1  0  0  0
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 21 23  1  0  0  0  0
 14 11  1  6  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002604

>  <SMILES>
Cc1cccc(S(=O)(=O)N2CC[C@@H]3[C@@H](CO[C@H]3CN(C)C)C2)c1

$$$$
SWF002605
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF002605

>  <SMILES>
O=C(NC1CC1)[C@@H]1CN(C(=O)Cc2ccc(F)cn2)C[C@H]2OCC[C@H]21

$$$$
SWF002606
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   12.0163   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.7663   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5491   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7626   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002606

>  <SMILES>
Cc1nc(C(=O)N2C[C@H]3OCC[C@H]3[C@H](C(=O)NCC3CC3)C2)cs1

$$$$
SWF002607
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1514    2.6721   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.8585    3.3792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3585    2.5132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9924    3.8792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3585    2.5132   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8585    1.6472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002607

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)C3(F)CC3)CCC21

$$$$
SWF002608
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002608

>  <SMILES>
CC1(C(=O)N2CCC3(CC2)CN(Cc2cccnc2)CCO3)CC=CCC1

$$$$
SWF002609
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -4.5583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
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  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002609

>  <SMILES>
Cn1cc(C(=O)NC2CCOC3(CCN(C(=O)Cc4ccccn4)CC3)C2)cn1

$$$$
SWF002610
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  6  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002610

>  <SMILES>
O=C(NCc1cccnc1)[C@H]1CN(Cc2ccccn2)[C@@H]2CCO[C@H]12

$$$$
SWF002611
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4791   -0.1818   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8325    0.5810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  5  9  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002611

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)c3cc[nH]n3)CC2)C1=O

$$$$
SWF002612
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002612

>  <SMILES>
c1ccc(CN2CC3(CC(OCc4ccncc4)CCO3)C2)nc1

$$$$
SWF002613
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002613

>  <SMILES>
CCC1COC2(CCN(C(=O)Cc3noc4ccccc34)C2)C1

$$$$
SWF002614
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4935    3.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6845    2.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5154    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0154    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812    1.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002614

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@H]2OCC[C@H]2[C@H](C(=O)N2CCCC2)C1

$$$$
SWF002615
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511   -2.2908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002615

>  <SMILES>
O=C(C1CCOC1)N1C[C@H](OCc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF002616
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9544   -4.9927   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5724   -4.9927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2634   -5.9437   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9763   -4.7847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -5.9437   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5235   -4.6836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5943   -6.6869   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3071   -5.5279   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6162   -6.4789   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002616

>  <SMILES>
CCC1COC2(CCN(C(=O)c3c(C)nc4ccccn34)C2)C1

$$$$
SWF002617
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
   -1.1549    2.8786   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2595    3.8731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3232    3.5367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3459    4.2799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3177    3.6413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8936    2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8071    1.9890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002617

>  <SMILES>
CNC(=O)[C@H]1CCC[C@]12CCN(C(=O)c1sccc1C)C2

$$$$
SWF002618
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6286    2.4068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2903    0.9205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0611    1.7829   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2521    2.3707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  8 10  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002618

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1S(C)(=O)=O

$$$$
SWF002619
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002619

>  <SMILES>
Cc1cc(=O)n2c(n1)CCC1(CCN(C(=O)c3csc(C)n3)C1)CC2

$$$$
SWF002620
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  7  1  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002620

>  <SMILES>
O=C(C1CC(F)(F)C1)N1C[C@@H]2CN(c3ncccn3)CCO[C@@H]2C1

$$$$
SWF002621
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.2437   -3.5933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128   -4.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347   -4.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002621

>  <SMILES>
c1nnc(N2CCCC3(CN(CC4CCCCC4)CCO3)C2)s1

$$$$
SWF002622
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 18 20  2  0  0  0  0
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 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002622

>  <SMILES>
C=CCN1CCOC2CCN(Cc3cccc(OC)c3)CCC21

$$$$
SWF002623
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
   10.5901    2.5008   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002623

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCN(C(=O)CC4=CCCCC4)CC3)[C@@H]1CN(C)C2

$$$$
SWF002624
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    7.0121   -6.5641   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10  8  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 20 21  2  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002624

>  <SMILES>
C=CCO[C@H]1CN(C(=O)c2cc(C)cs2)[C@@H]2CCCO[C@H]12

$$$$
SWF002625
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1383   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3293   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8074   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8019   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2087   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.5708   -3.9706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5653   -3.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002625

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)c3ccccc3)C2)C1

$$$$
SWF002626
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   10.3610    0.3478   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2042   -1.1439   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5745   -0.5338   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6130    2.1715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3995    3.0531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6483    2.6065   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5790    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1118    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002626

>  <SMILES>
O=S(=O)(C1CC1)N1C[C@@H](OCCCn2cccn2)[C@@H]2OCCC[C@H]21

$$$$
SWF002627
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 13 11  1  1  0  0  0
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 13 15  1  0  0  0  0
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 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
 27 29  3  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 20 22  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002627

>  <SMILES>
N#Cc1cccc(N2CCOCC3(CCCN(C(=O)c4cccc(Cl)c4)C3)C2)c1

$$$$
SWF002628
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    6.9282    1.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4282    0.6340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9282    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  2  0  0  0  0
 17 19  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF002628

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CC2CCCC(C1)C2CC(=O)NCc1ccco1

$$$$
SWF002629
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002629

>  <SMILES>
Cc1ccc(CN2Cc3ccnn3C(C(=O)N3CC(F)(F)C3)C2)o1

$$$$
SWF002630
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  1  0  0  0
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 11 15  1  0  0  0  0
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 15 17  1  0  0  0  0
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 17 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002630

>  <SMILES>
O=C(c1cc[nH]c1)N1CC[C@@H]2OCCN(S(=O)(=O)C3CC3)[C@H]2C1

$$$$
SWF002631
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002631

>  <SMILES>
O=C([C@@H]1C[C@H]2OCC[C@H]2N(C(=O)c2cc[nH]c2)C1)N1CCCC1

$$$$
SWF002632
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 18 20  2  0  0  0  0
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 21 22  2  0  0  0  0
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 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002632

>  <SMILES>
C=CCN1C(=O)CC2C1CCN2C(=O)Cc1ccc(F)cn1

$$$$
SWF002633
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7670    3.4431   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7725    3.3385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002633

>  <SMILES>
c1ccc(CN2CCCC3(CCN(C4CCOCC4)C3)C2)nc1

$$$$
SWF002634
Actelion Java MolfileCreator 1.0

 31 34  0  0  1  0  0  0  0  0999 V2000
    7.7832   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5332   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5844   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
 26 30  1  0  0  0  0
 27 31  2  0  0  0  0
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 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
>  <HTSID>
SWF002634

>  <SMILES>
CN(C)c1ccccc1CN1CCOC[C@@]2(CC[C@H](CNC(=O)C3CC(F)(F)C3)O2)C1

$$$$
SWF002635
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1707   -7.8781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5442   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6539   -7.0431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1457   -7.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002635

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(=O)N(CC2CCC2)C3)C1

$$$$
SWF002636
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6530   -2.3227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7019   -2.6317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2408   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7019   -3.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6530   -3.9407   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2408   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1667   -5.2790   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1178   -5.5880   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  2  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  6  0  0  0
  9 16  1  0  0  0  0
 10 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 16 20  1  1  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002636

>  <SMILES>
CO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1nc2ccccn2c1C

$$$$
SWF002637
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8800    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1625   -2.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6780   -4.9689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1759   -7.5180   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1890   -8.6476   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002637

>  <SMILES>
O=C1CCCN1C[C@H]1CC[C@]2(COCCN(Cc3ccc(-n4ccnc4)cc3)C2)O1

$$$$
SWF002638
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4423   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0524   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1707   -7.8781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5442   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5479   -5.7067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7614   -7.8086   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9182   -6.3168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002638

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cc[nH]n3)CC2)CN1CC1CCC1

$$$$
SWF002639
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   -0.1499    1.1118   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109   -4.4672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002639

>  <SMILES>
O=C([C@@H]1CN(C(=O)C2(F)CC2)C[C@H]2OCC[C@H]21)N1CCOCC1

$$$$
SWF002640
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002640

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF002641
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    4.2419   -2.5657   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9955   -1.2605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4943   -1.1030   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3768   -0.1406   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1575   -2.2523   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6388    1.0920   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6317   -2.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.3220   -6.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 28 31  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
 29 31  2  0  0  0  0
M  END
>  <HTSID>
SWF002641

>  <SMILES>
Cc1nc(CN2CCC3(CN(C(=O)c4ccnn4C)CC3c3cn(C)cn3)C2=O)cs1

$$$$
SWF002642
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.7942    9.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    9.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  7  2  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002642

>  <SMILES>
COCCCN1CCCC2(CCCN(C(=O)C3=CC=NC(=O)C3)C2)C1

$$$$
SWF002643
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.3454    1.7454   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9441    2.7635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9496    2.8680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4496    3.7340   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2805    2.1248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 13  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002643

>  <SMILES>
CCO[C@H]1CO[C@]2(CCCN(C(=O)Cc3ccn(C)n3)C2)C1

$$$$
SWF002644
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1240   -2.4385   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5711    0.5280   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0021    0.9152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7947    2.0112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2256    2.3984   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6219    2.9464   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 12 13  2  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002644

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1C[C@@H]2CN(C(=O)c3ccccc3)CCO[C@@H]2C1

$$$$
SWF002645
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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 25 26  1  0  0  0  0
 10 14  1  0  0  0  0
 13 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002645

>  <SMILES>
COc1ccc(C[C@H]2CN(C(=O)c3ccccc3C)CC[C@H]2OC)cc1

$$$$
SWF002646
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 10 12  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002646

>  <SMILES>
CN(C)S(=O)(=O)N1CC[C@H]2C[C@H](C(=O)N3CCCC3)O[C@@H]2C1

$$$$
SWF002647
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 16 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002647

>  <SMILES>
COc1cc(C(=O)N2CCC3(COc4ccccc43)C2)on1

$$$$
SWF002648
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.3971   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  2  0  0  0  0
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 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002648

>  <SMILES>
O=C(c1ccnc(C(F)(F)F)c1)N1CCC2(COc3ccccc32)C1

$$$$
SWF002649
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.5442   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002649

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(OC)CO3)cn1

$$$$
SWF002650
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002650

>  <SMILES>
COC1COC2(CCN(C(=O)c3ncnc(C)c3C)CC2)C1

$$$$
SWF002651
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.7549   -2.2418   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  1  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002651

>  <SMILES>
O=C(c1ccns1)N1CCCC2(CCCN(CC3CC3)C2)C1

$$$$
SWF002652
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    8.4371    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0303   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6181   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002652

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3conc3C)CC2)CC1COC

$$$$
SWF002653
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0352    3.2820   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 11  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002653

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@H](N2CCOCC2)[C@@H]2OCCC[C@@H]21

$$$$
SWF002654
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002654

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CCC(=O)NC3)CC2)cc1

$$$$
SWF002655
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.4779    2.6929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6811    3.9801   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5946    4.3868   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0120    4.7232   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002655

>  <SMILES>
C=CCN1CCCC12CCN(C(=O)c1cc(OC)no1)CC2

$$$$
SWF002656
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 17 19  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002656

>  <SMILES>
Cn1cncc1CN1CCCC2(C1)CN(CC1CCCCC1)C2=O

$$$$
SWF002657
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8 10  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002657

>  <SMILES>
CO[C@H]1CCN(C(=O)Cc2ccn(C)n2)[C@H]1Cc1ccccc1

$$$$
SWF002658
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002658

>  <SMILES>
CCN1CCC2(CCN(C(=O)c3ccsc3)CC2)CC1=O

$$$$
SWF002659
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 22 25  1  0  0  0  0
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 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002659

>  <SMILES>
O=C(N1CCCC2(CCCN2Cc2ccc(F)cc2)CC1)C1(F)CC1

$$$$
SWF002660
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002660

>  <SMILES>
Cc1ncnc(C(=O)N2CCC3(CC2)CC(N(C)C)C3)c1C

$$$$
SWF002661
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002661

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CC2)CNC(=O)CO3)cc1

$$$$
SWF002662
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002662

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1CC1CC1

$$$$
SWF002663
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.6425    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    4.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8925    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7824    1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    2.2172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090   -1.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2453    0.3700   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002663

>  <SMILES>
CN(C)C(=O)[C@@]12CCC3(CCNCC3)[C@@H]1CN(S(C)(=O)=O)C2

$$$$
SWF002664
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002664

>  <SMILES>
O=C(c1ccncn1)N1CCO[C@H]2[C@H](OCC3CCCC3)CC[C@@H]21

$$$$
SWF002665
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.5471   -4.4801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3392   -3.5019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0823   -2.8328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3881   -3.1929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6176   -1.1855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9209   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2299   -3.1929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4209   -4.7807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002665

>  <SMILES>
COCCC1CCOC12CCN(C(=O)c1occc1C)CC2

$$$$
SWF002666
Actelion Java MolfileCreator 1.0

 19 21  0  0  1  0  0  0  0  0999 V2000
    4.8669    1.2340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1978    1.9771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6100    1.9031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1456    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2283   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002666

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2CCN(C(=O)c3csnn3)[C@@H]2C1

$$$$
SWF002667
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   10.5328   -2.3153   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.4721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7711   -0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4721    0.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4721   -3.8527   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 11  1  1  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002667

>  <SMILES>
O=C([C@H]1C[C@@H]2CCN(C(=O)C3(F)CC3)C[C@H]2O1)N1CCCC1

$$$$
SWF002668
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002668

>  <SMILES>
O=C(C1CC(F)C1)N1CC[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF002669
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002669

>  <SMILES>
COCCN1CC(COC)C2(CCN(C(=O)COC)CC2)C1

$$$$
SWF002670
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    8.2350   -0.1340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  2  1  1  0  0  0
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 10  7  1  6  0  0  0
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 23 24  1  0  0  0  0
 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF002670

>  <SMILES>
COCCN1CC[C@H]2C[C@H](C(=O)N(C)Cc3ccccn3)O[C@H]2C1

$$$$
SWF002671
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    9.3372   -0.6842   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002671

>  <SMILES>
O=C(NCC1CCOCC1)[C@@H]1C[C@@H]2[C@@H](CCN2Cc2ccsc2)O1

$$$$
SWF002672
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002672

>  <SMILES>
COC[C@H]1CN(CC2CC2)C[C@@]12CCN(Cc1cccc(C)n1)C2

$$$$
SWF002673
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.8058    2.2798   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8085    2.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 13 18  2  0  0  0  0
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 22 25  1  0  0  0  0
 12 14  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002673

>  <SMILES>
Cc1ccc2c(n1)N(CC(C)C)CCN(C(=O)Cc1ccccn1)C2

$$$$
SWF002674
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002674

>  <SMILES>
CC1CC(C(=O)N2CCO[C@H]3[C@@H](Oc4ccccn4)CC[C@@H]32)C1

$$$$
SWF002675
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002675

>  <SMILES>
Cn1cc(CN2CC3(CC(Oc4ncccc4F)CCO3)C2)cn1

$$$$
SWF002676
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.6108    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6245   -0.7576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002676

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF002677
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 20 22  1  0  0  0  0
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 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002677

>  <SMILES>
COc1cccc(CN2C[C@@H]3COC[C@]3(C(=O)N(C)C)C2)c1

$$$$
SWF002678
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.2855   -5.6077   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  1  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002678

>  <SMILES>
O=C(NCC1CC1)[C@H]1C[C@@H]2CN(Cc3ccccc3F)C[C@H]1O2

$$$$
SWF002679
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4856    7.7624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3838    6.2353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 10  1  1  0  0  0
 17 20  1  0  0  0  0
 19 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002679

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1=NOC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002680
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.6808    4.6665   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.1808    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 16 14  1  1  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002680

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CCN(C(=O)c3cccc(Cl)c3)C[C@@H]2O1

$$$$
SWF002681
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002681

>  <SMILES>
O=C(c1ccncn1)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF002682
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.0190   -2.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002682

>  <SMILES>
Fc1cnc(N2CC3(CC(OCc4ccncc4)CCO3)C2)nc1

$$$$
SWF002683
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002683

>  <SMILES>
COc1ccc(-c2cnc3n2CCN(C(=O)c2cccc(F)c2C)CC3)cc1

$$$$
SWF002684
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002684

>  <SMILES>
Cc1ncnc(C(=O)N2CCC3(CCc4nnc(C(=O)NC5CCCC5)n4CC3)C2)c1C

$$$$
SWF002685
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF002685

>  <SMILES>
N#CC1(C(=O)N2CCc3ncnc(C4CC4)c3CC2)CCCC1

$$$$
SWF002686
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002686

>  <SMILES>
COCc1ccc(C(=O)N2CCC3(CC2)CC(=O)N(CC2CC2)C3)cc1

$$$$
SWF002687
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002687

>  <SMILES>
O=C1NC2(CCN(S(=O)(=O)c3ccccn3)CC2)[C@H]2CN(CC3CCCC3)C[C@@H]12

$$$$
SWF002688
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002688

>  <SMILES>
Cn1cc(CN2CCC3(CCC(CC(=O)N4CCCC4)CC3)CC2)cn1

$$$$
SWF002689
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002689

>  <SMILES>
COCc1ccc(C(=O)N2CCc3ncnc(C4CC4)c3CC2)cc1

$$$$
SWF002690
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002690

>  <SMILES>
O=C(C1CC1)N1CCC(F)(F)C2(CCN(c3cccc(F)c3)C2)C1

$$$$
SWF002691
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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 11 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF002691

>  <SMILES>
O=C(NCc1cn2c(n1)CN(Cc1cccs1)CC2)C1CCC1

$$$$
SWF002692
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002692

>  <SMILES>
Cc1ccc(C(=O)N2CCC[C@@H]3CN(C(=O)c4ccco4)C[C@@H]32)o1

$$$$
SWF002693
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002693

>  <SMILES>
CCOC1COC2(CCN(Cc3ccc(C)c(C)c3)CC2)C1

$$$$
SWF002694
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002694

>  <SMILES>
O=C(c1cc(F)ncc1F)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF002695
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002695

>  <SMILES>
CC(=O)Nc1cccc(-c2cnc3n2CCN(C(=O)c2ccnnc2)CC3)c1

$$$$
SWF002696
Actelion Java MolfileCreator 1.0

 30 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002696

>  <SMILES>
O=c1c(-c2ccccc2)nnc2n1CCC21CCN(Cc2ccc3c(c2)OCO3)C1

$$$$
SWF002697
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002697

>  <SMILES>
c1ccc(CN2CCC3(CCn4c(-c5cccs5)cnc43)C2)nc1

$$$$
SWF002698
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002698

>  <SMILES>
CN1CCC(COc2ccccn2)CC12CN(C(=O)c1cc3ccccc3[nH]1)C2

$$$$
SWF002699
Actelion Java MolfileCreator 1.0

 32 37  0  0  0  0  0  0  0  0999 V2000
    8.5346   -1.4546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9468   -2.2636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF002699

>  <SMILES>
O=C(NC1CCCC1)c1nnc2n1CCC1(CC2)CCN(C(=O)c2cc(C3CC3)on2)C1

$$$$
SWF002700
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    3.4641    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002700

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF002701
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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   11.0184   -3.6570   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002701

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)Cc3cccc(F)c3F)C2)C1

$$$$
SWF002702
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 22  1  1  0  0  0
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 21 24  1  0  0  0  0
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  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002702

>  <SMILES>
O=C(NCC1CC1)[C@H]1CN(C(=O)CCc2ccccc2F)C[C@H]2OCC[C@@H]12

$$$$
SWF002703
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2074   -1.2006   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9939   -3.3024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4131    0.4183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1896   -6.1982   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  2  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002703

>  <SMILES>
OCc1ccc(CN2CC3(CC(CO)CN3CC3CC3)C2)cc1

$$$$
SWF002704
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.6211    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3121    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9812   -0.2127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9594   -0.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3413   -1.9069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6285   -0.7479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3195   -1.6990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9886   -2.4421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  1  0  0  0
 16 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 13 10  1  6  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002704

>  <SMILES>
C[C@H]1CC[C@H](C(=O)N2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NC3CC3)C2)CC1

$$$$
SWF002705
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8109    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1418    2.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4508    3.0741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2183    3.8172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0907    4.7683   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1965    3.6093   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8656    4.3525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5055    2.6583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8438    4.1445   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4836    2.4503   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1528    3.1935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002705

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF002706
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9578    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8365    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.6213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6160    1.3398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9262    2.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1170    3.9724   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8554    2.0417   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3226    2.3535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8591    0.9269   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  2  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 12 14  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002706

>  <SMILES>
O=C(NCc1cnc2n1CCN(C(=O)C1CC1)CC2)C1CCC1

$$$$
SWF002707
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4472   -5.2521   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7562   -6.2031   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1381   -6.2031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002707

>  <SMILES>
Cn1ncnc1C(=O)N1CCC2(CC1)COC(CN1CCOCC1)C2

$$$$
SWF002708
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.3456   -3.8113   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5658   -1.0707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.4474   -2.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002708

>  <SMILES>
Cn1c(C(=O)N2CCC3(CC2)CCN(c2ncccn2)C3)cccc1=O

$$$$
SWF002709
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002709

>  <SMILES>
O=C1CC[C@@H]2[C@@H](CCN2C(=O)C2[C@H]3COC[C@@H]23)N1Cc1ccncc1

$$$$
SWF002710
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002710

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(CC2CC2)CCC3(F)F)cs1

$$$$
SWF002711
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  1  0  0  0
  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
  5 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  2  0  0  0  0
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 22 26  2  0  0  0  0
 23 27  1  0  0  0  0
 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 21 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002711

>  <SMILES>
COc1cccc(CN2C[C@@]3(F)CN(C(=O)/C=C/c4c[nH]cn4)C[C@@]3(F)C2=O)c1

$$$$
SWF002712
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF002712

>  <SMILES>
CC1(C(=O)N2CCC(C3C(=O)Nc4ccc(C(=O)NC5CCCC5)cc43)CC2)CC=CCC1

$$$$
SWF002713
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3293   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8074   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8019   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3897   -2.2480   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.6209    0.2836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2032   -0.4209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002713

>  <SMILES>
CC(C)C(=O)N1CCC2(CN(C(=O)Cc3ccc(F)cn3)C2)C1

$$$$
SWF002714
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5807   -5.7695   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6405   -4.7713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5349   -4.3239   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8059   -4.2204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5947   -3.3257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8657   -3.2222   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4890   -2.8784   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7601   -2.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3236   -3.4293   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5488   -1.8802   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754   -1.3932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4742   -1.5010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7546   -0.5411   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1790    0.2766   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  8  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002714

>  <SMILES>
O=C(NC1CCC1)c1nnn2c1CN(C(=O)c1cccc(Cl)n1)CCC2

$$$$
SWF002715
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4871    0.7241   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7567   -0.4540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1672    1.4572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4369    0.2791   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1422    1.2347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4118    0.0566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8223    1.9677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7066   -0.8990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002715

>  <SMILES>
CCN1CC2(COCCN(C(=O)c3cccc(Cl)n3)C2)OCC1=O

$$$$
SWF002716
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.6617   -3.7751   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.7764   -4.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0883   -3.3116   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1982   -2.3486   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6580   -4.8899   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7310   -2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1908   -4.5780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002716

>  <SMILES>
CN(C)S(=O)(=O)N1CCc2c(c(COc3cccnc3)nn2C)C1

$$$$
SWF002717
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.2681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413   -1.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7104    0.4750   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5194   -0.9262   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6240    0.0683   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4900    0.5683   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9781   -0.7079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1691   -2.1092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 20 16  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002717

>  <SMILES>
Cn1cc(N2CCC3(CCCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3)C2=O)cn1

$$$$
SWF002718
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002718

>  <SMILES>
O=C(N1CCC2(CC(Nc3cnccn3)CO2)C1)C1(F)CCC1

$$$$
SWF002719
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1314    2.2739   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002719

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCC2(COc3ccccc32)C1

$$$$
SWF002720
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6  9  1  0  0  0  0
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 11 13  1  0  0  0  0
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 15 13  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002720

>  <SMILES>
O=C(Cn1ccccc1=O)N1C[C@@H]2CCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF002721
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  6  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002721

>  <SMILES>
O=C([C@H]1CO[C@@H]2CN(CC3CCCCC3)C[C@H]12)N1CCCC1

$$$$
SWF002722
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002722

>  <SMILES>
Cc1ccc(C(=O)N2C[C@H]3C[C@H](CNC(=O)C4CCC4)O[C@H]3C2)cn1

$$$$
SWF002723
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
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  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8  9  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002723

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@@H]2COC[C@]2(COCC2CCOCC2)C1

$$$$
SWF002724
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.1215   -6.3164   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6580   -4.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6617   -3.7751   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1908   -4.5780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1982   -2.3486   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7273   -3.1514   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1871   -5.6927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7310   -2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2600   -2.8395   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002724

>  <SMILES>
CN(C)Cc1noc2c1CC(NC(=O)c1ccccn1)CC2

$$$$
SWF002725
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5904    2.9183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5867    1.8036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0692    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3400    5.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3400    7.2971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0409    8.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  5  1  1  6  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002725

>  <SMILES>
CC(C)CN1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2S1(=O)=O

$$$$
SWF002726
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002726

>  <SMILES>
O=C(COC1CCOC2(C1)CN(Cc1ccccn1)C2)N1CCCC1

$$$$
SWF002727
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    9.0933   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 15 14  1  6  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 13  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002727

>  <SMILES>
O=C(CNC(=O)c1cccnc1)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF002728
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 20 24  2  0  0  0  0
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  7 10  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002728

>  <SMILES>
c1cc(CO[C@H]2CN(CCN3CCCC3)[C@@H]3CCCO[C@H]23)ccn1

$$$$
SWF002729
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 11  1  6  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002729

>  <SMILES>
CC1N(c2cccnc2)C(=O)COC12CCN(CC1CC1)CC2

$$$$
SWF002730
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2800    3.2340   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1679    3.7664   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8229    4.2035   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139    4.6575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  8  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002730

>  <SMILES>
O=C(N1CCOC2C(CNc3ncccn3)CCC21)C1(F)CCC1

$$$$
SWF002731
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002731

>  <SMILES>
O=S(=O)(NC1CCc2onc(CN3CCOCC3)c2C1)C1CC1

$$$$
SWF002732
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  9  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002732

>  <SMILES>
COc1cccc(N2CC3(CCN(C(=O)C4(F)CCC4)C3)CC2=O)c1

$$$$
SWF002733
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
   11.2955   -3.0240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4138   -4.2376   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0239   -5.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.4912   -5.9197   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2776   -8.0216   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  2  0  0  0  0
 19 20  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002733

>  <SMILES>
O=C(NCc1cccnc1)C1=NOC2(CCCN(C(=O)c3cc(C4CC4)on3)C2)C1

$$$$
SWF002734
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8106    0.7391   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    1.3625   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233    0.9972   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4434    2.3514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2253    2.9749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4243   -0.5633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0762    3.9637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1561    2.6095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3799   -0.2686   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9144    2.2715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9380    3.2330   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7234    0.8702   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8279    1.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7889    4.2218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5708    4.8453   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 22 23  1  0  0  0  0
 13 15  1  0  0  0  0
 18 22  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF002734

>  <SMILES>
COCC1CCn2nccc2CN1C(=O)Cc1ccc(C)cc1

$$$$
SWF002735
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   14.6144   -4.0537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   15.3644   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1472   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3607   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.8562   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002735

>  <SMILES>
CNC(=O)CN1CCC2(CCCN(C(=O)c3csc(C)n3)C2)CC1

$$$$
SWF002736
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.6513   -2.6970   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5024   -6.7584   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  1  0  0  0  0
  3  7  2  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  2  0  0  0  0
  6 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
  5  7  1  0  0  0  0
  8 10  2  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002736

>  <SMILES>
CC1CCN(C(=O)c2cc3c(CNC(=O)c4cc[nH]n4)nn(C)c3s2)CC1

$$$$
SWF002737
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9231   -3.3037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2506   -5.8132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6388   -7.2621   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0877   -7.6503   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4760   -9.0992   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4153  -10.1599   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8035  -11.6088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9664   -9.7716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7429  -12.6694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9058  -10.8323   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2940  -12.2812   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002737

>  <SMILES>
O=C(c1cscn1)N1CC2CN(C3CCN(Cc4ccccc4)CC3)C2C1

$$$$
SWF002738
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3041   -2.9149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002738

>  <SMILES>
CN(C)C(=O)NC[C@H]1OC[C@@H]2CCN(Cc3ccoc3)C[C@@H]21

$$$$
SWF002739
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.2669   -7.0085   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8034   -5.5819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3361   -5.2701   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8071   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8726   -3.8435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2988   -4.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4054   -3.5316   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9089   -3.2537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -2.5279   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9788   -3.9951   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002739

>  <SMILES>
CC(C)C(=O)NC1CCc2onc(C(=O)NCC3CC3)c2C1

$$$$
SWF002740
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002740

>  <SMILES>
CC(=O)N1CCC2(CCC(CC(=O)N3CCCC3)CC2)CC1

$$$$
SWF002741
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0252   -3.7327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 17 15  1  6  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002741

>  <SMILES>
O=C(COc1cc(F)ccc1F)N1C[C@@H]2C(C(=O)N3CCCC3)=NO[C@@H]2C1

$$$$
SWF002742
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002742

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCc2ncnc(-c3ccncc3)c2C1

$$$$
SWF002743
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7511    4.1310   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6864    5.3037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2031    5.5272   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3178    3.6888   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9905    3.2860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7698    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1026    1.7902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2299    4.1310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5198    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2865    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0030    0.7699   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4541    1.1393   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5813    3.4801   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9718   -0.4028   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002743

>  <SMILES>
O=S1(=O)N[C@H]2CCN(c3ncccn3)CC[C@@H]2Oc2ccccc21

$$$$
SWF002744
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0314   -1.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 24  2  0  0  0  0
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  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002744

>  <SMILES>
N#Cc1cccc(NC2COC3(CCN(C(=O)C4(F)CCC4)C3)C2)c1

$$$$
SWF002745
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    9.0321    1.7786   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5484    1.5123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8581    0.7561   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2516    0.2474   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3097    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3097    1.5123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6194   -2.2684   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  2  0  0  0  0
  6 10  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002745

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC(C(=O)N2CCC2)(n2cccn2)CC1

$$$$
SWF002746
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8481    3.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  2  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002746

>  <SMILES>
Cn1cnc2c1CC(COc1ccccn1)N(S(=O)(=O)C1CC1)C2

$$$$
SWF002747
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.9673   -2.6559   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002747

>  <SMILES>
O=C(NC1CCCC1)c1nnc2n1CCCN(C(=O)c1csnn1)C2

$$$$
SWF002748
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6921   -3.1397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -4.7577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6432   -3.4487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 23 27  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002748

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC3OCCN(Cc4c(C)noc4C)C3C2)n[nH]1

$$$$
SWF002749
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   13.5175    0.2010   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.7675    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2675    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.3793    2.9489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3186    1.1118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314    4.8107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    2.5607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002749

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)C3CC(F)(F)C3)CC2)C1)c1cccnc1

$$$$
SWF002750
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002750

>  <SMILES>
CN(c1ncccn1)C1COC2(CCCN(C(=O)C3CC3)C2)C1

$$$$
SWF002751
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002751

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC3C(=O)N3CCOCC3)C2)cs1

$$$$
SWF002752
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
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 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002752

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CCC2CN(C(C)C)CCOC2C1

$$$$
SWF002753
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
    6.9282    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
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 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002753

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2CCC1c1cnc(NCC3CC3)nc12

$$$$
SWF002754
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002754

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)c4csc(C)n4)C3)C2=O)n1

$$$$
SWF002755
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
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 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002755

>  <SMILES>
COc1ccc(CN2C(=O)CCC23CCN(C(C)C)CC3)cc1

$$$$
SWF002756
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    9.6213    8.4196   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1541    8.1078   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6176    9.5343   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.6562    8.1863   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0364    6.1482   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7748    4.2174   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7711    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002756

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)C3CC(F)(F)C3)C[C@H]2C)C1=O

$$$$
SWF002757
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF002757

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3nc4ccccn4c3C)C[C@H]2C)C1=O

$$$$
SWF002758
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3052    3.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10  8  1  6  0  0  0
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 13 15  1  1  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002758

>  <SMILES>
O=C([C@@H]1CCO[C@@H]2CCN(C(=O)C3(F)CC3)C[C@H]21)N1CCCC1

$$$$
SWF002759
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.0049   -3.5797   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6162   -1.4013   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002759

>  <SMILES>
O=C(N1CC[C@H]2OCC[C@@]2(C(=O)Nc2cccnc2)C1)C1(F)CC1

$$$$
SWF002760
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9781   -0.7079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6629    2.8653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0430    5.8018   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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  7  8  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002760

>  <SMILES>
CC(C)N1CCOC2CN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CCC2C1

$$$$
SWF002761
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9956    1.8138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8910    2.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9737    1.6059   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8046    3.2150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4737    2.4719   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2653    2.0238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8005    0.3765   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6858    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8937    0.7366   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  6  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002761

>  <SMILES>
CCO[C@H]1CCN(C(=O)[C@H]2[C@@H]3COC[C@@H]32)[C@H]1Cc1ccccc1

$$$$
SWF002762
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647    1.8841   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602    2.8786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8937    0.7366   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002762

>  <SMILES>
CCO[C@H]1CCN(C(=O)c2ncn(C)n2)[C@H]1Cc1ccccc1

$$$$
SWF002763
Actelion Java MolfileCreator 1.0

 31 35  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2024    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9964   -3.4644   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6655   -4.2076   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3565   -5.1586   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4054   -5.4677   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  6  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002763

>  <SMILES>
CCn1cc(CN2CCC3(CC2)CC[C@@]2(C(=O)N4CCCC4)CN(C(C)=O)C[C@@H]32)cn1

$$$$
SWF002764
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.0466    1.2436   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646    0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -0.7568   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646    2.2703   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431    2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3130    1.7892   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0228    3.7756   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2601    2.7795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5033    4.0903   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3108   -3.0271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002764

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)Cc2ccccc2)CC1

$$$$
SWF002765
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
 20 22  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002765

>  <SMILES>
O=C(c1cccnc1)N1CCc2nn3ccc(NC4CCCC4)nc3c2C1

$$$$
SWF002766
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002766

>  <SMILES>
Cc1ccc(CN2CCC(C(=O)N(C)C)(n3ccnc3)CC2)cc1

$$$$
SWF002767
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF002767

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1C[C@@H]2OCCN(CC3CCCC3)[C@H]2C1

$$$$
SWF002768
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 19 21  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002768

>  <SMILES>
CC(C)CCNC(=O)c1nnc2n1CC1(CC2)CCN(C(=O)c2ccnc(F)c2)CC1

$$$$
SWF002769
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
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 20 17  1  1  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
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 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002769

>  <SMILES>
C[C@@H]1CN(C(=O)[C@H]2[C@@H]3COC[C@@H]32)C[C@]12CCN(c1cccnc1)C2=O

$$$$
SWF002770
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5373   -0.8726   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 13 15  2  0  0  0  0
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 20 24  2  0  0  0  0
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 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 22 25  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002770

>  <SMILES>
Cc1ccc(N2CCC3(CN(C(=O)c4ncn(C)n4)CCC3(F)F)C2)nn1

$$$$
SWF002771
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    4.2047    0.2626   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  6  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 26 27  1  0  0  0  0
  8  9  2  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002771

>  <SMILES>
Cc1ccc(CN2C(=O)C[C@H]3[C@@H]2CCN3Cc2ncc(C(F)(F)F)[nH]2)cc1

$$$$
SWF002772
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -3.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9480   -3.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002772

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CC1)CCN(c1cccnc1)C2=O

$$$$
SWF002773
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002773

>  <SMILES>
Cc1nc(C(=O)N2CC3(C2)CN(C)c2nccnc23)cs1

$$$$
SWF002774
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002774

>  <SMILES>
O=C(C1CCC1)N1CCC(Nc2cccc(F)c2)(C(=O)NC2CC2)CC1

$$$$
SWF002775
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.7477   -4.2110   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4387   -3.2599   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1078   -2.5168   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4605   -3.0520   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1515   -2.1009   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8206   -1.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  2  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002775

>  <SMILES>
COc1ccc(C(=O)NC2CCc3onc(CN(C)C)c3C2)cc1

$$$$
SWF002776
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -8.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002776

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3cccc(OC)c3)C2)CN1CC1CC1

$$$$
SWF002777
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481    2.4510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481    2.4510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002777

>  <SMILES>
CC(C)Nc1ccnc(C2COCCN2S(=O)(=O)C2CC2)n1

$$$$
SWF002778
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.0124    1.0516   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6914    2.8919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5472    2.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002778

>  <SMILES>
O=C(N1CCCC2(CCN(CC3CC3)C2=O)C1)C1(F)CCC1

$$$$
SWF002779
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002779

>  <SMILES>
O=C(C1CC1)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF002780
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.0020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    3.0020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6532    2.7941   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9016   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3223    3.5372   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2218    4.7621   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0133    4.4883   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002780

>  <SMILES>
COc1cc(C(=O)N2CC3(C2)CN(C)c2nccnc23)on1

$$$$
SWF002781
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6603    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  2  0  0  0  0
 16 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 17  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002781

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCCN(C(=O)COC)C1

$$$$
SWF002782
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.9187   -3.4822   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4208   -3.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4563   -4.8826   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0325   -5.0096   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4768   -2.3950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9051   -5.2708   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002782

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccc(C)s2)C1

$$$$
SWF002783
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002783

>  <SMILES>
C=CC(=O)N1CCC(C(=O)Nc2ccn(C)n2)(n2cccn2)CC1

$$$$
SWF002784
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 12  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002784

>  <SMILES>
CC(C)CNc1nc2c(cc1C(=O)N(C)C)CCN(c1ncccn1)CC2

$$$$
SWF002785
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002785

>  <SMILES>
COCCn1cc2c(n1)C(CNC(=O)CN(C)C(C)C)OCC2

$$$$
SWF002786
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 16 19  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002786

>  <SMILES>
Cc1ccc(CC(=O)N2CC(C(=O)NCC3CCOCC3)C3OCCC32)cc1

$$$$
SWF002787
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    6.0725   -4.1572   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
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 19 20  1  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002787

>  <SMILES>
CC1CC(C(=O)N2CC[C@@H]3CN(C)S(=O)(=O)[C@@H]3CC2)C1

$$$$
SWF002788
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  6  0  0  0
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 15 18  1  0  0  0  0
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 21 22  1  0  0  0  0
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  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002788

>  <SMILES>
COCC1CN(Cc2cccs2)CC12CCN(CC1CCC1)CC2

$$$$
SWF002789
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 12 15  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002789

>  <SMILES>
CCS(=O)(=O)NCCC1CCOC12CN(Cc1ccc(C)cc1)C2

$$$$
SWF002790
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002790

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CCN(c2cccnc2)C3=O)C1

$$$$
SWF002791
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6479    2.0749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
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  6 10  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 20 22  2  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002791

>  <SMILES>
CCOCCC1CCOC12CCN(Cc1ccccn1)CC2

$$$$
SWF002792
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  3  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
  4  7  1  0  0  0  0
 14 15  2  0  0  0  0
 19 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002792

>  <SMILES>
CC(=O)N(C)c1ncc(-c2nc(C(=O)N3CCN(C(C)C)CC3)c3ccccn23)s1

$$$$
SWF002793
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.0785    0.1661   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0748    1.2808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  2  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002793

>  <SMILES>
CNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cccnc2)CC1

$$$$
SWF002794
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.2417   -0.7566   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002794

>  <SMILES>
COCCNC(=O)C1(n2ccnc2)CCN(Cc2ccccc2)CC1

$$$$
SWF002795
Actelion Java MolfileCreator 1.0

 28 33  0  0  1  0  0  0  0  0999 V2000
    2.6295    0.0146   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 13 18  1  0  0  0  0
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 15 21  1  0  0  0  0
 15 22  1  0  0  0  0
 16 23  1  0  0  0  0
 19 24  2  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  8  9  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 17 23  1  0  0  0  0
 18 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002795

>  <SMILES>
O=C(NC12CC3CC(CC(C3)C1)C2)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF002796
Actelion Java MolfileCreator 1.0

 35 40  0  0  1  0  0  0  0  0999 V2000
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   -1.7053    2.1809   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  2  0  0  0  0
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 21 26  2  0  0  0  0
 23 27  2  0  0  0  0
 23 28  1  0  0  0  0
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 28 31  2  0  0  0  0
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 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  1  0  0  0  0
 22 24  1  0  0  0  0
 26 30  1  0  0  0  0
 27 29  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <HTSID>
SWF002796

>  <SMILES>
O=C(NC1CC1)c1nnc2n1C[C@@H]1N(C(=O)Cn3ccccc3=O)CC[C@]1(c1ccccc1)CC2

$$$$
SWF002797
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.9314    1.5132   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002797

>  <SMILES>
O=C(N1CCC1)C1(n2ccnc2)CCN(Cc2ccccc2Cl)CC1

$$$$
SWF002798
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  5  7  1  0  0  0  0
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  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 10  1  1  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 26  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002798

>  <SMILES>
CCn1cc(CN2CC[C@H]3[C@@H]2CC(=O)N3Cc2cc(F)cc(F)c2)cn1

$$$$
SWF002799
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.2685    3.7435   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002799

>  <SMILES>
Cc1ncsc1CN1CCn2cc(C(=O)NC3CC3)nc2C1C

$$$$
SWF002800
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 27 28  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002800

>  <SMILES>
Cc1nc(CN2CC[C@@H]3CN(C(=O)Nc4ccc(F)c(F)c4)C[C@@H]3CC2)cs1

$$$$
SWF002801
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002801

>  <SMILES>
O=C(C1CCC1)N1CC(F)(F)CC2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF002802
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4135    0.7728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  6  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002802

>  <SMILES>
Cc1nc(CN2C[C@H](C(=O)N3CCCC3)[C@H]3OCC[C@H]32)c[nH]1

$$$$
SWF002803
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002803

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CC(=O)N(Cc2cccc(F)c2)C3)n1

$$$$
SWF002804
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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   11.1597   -3.6121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
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 25 27  1  0  0  0  0
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 27 29  2  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002804

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CC3(C2)OCCC3CCNC(=O)c2ccncc2)cc1

$$$$
SWF002805
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF002805

>  <SMILES>
CC1CC(C(=O)N2C[C@H]3COC[C@@H](N4CCN(C)CC4)[C@H]3C2)C1

$$$$
SWF002806
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  2  0  0  0  0
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M  END
>  <HTSID>
SWF002806

>  <SMILES>
O=C(N1CCc2ncnc(-c3ccncc3)c2CC1)C12CC(C1)C2

$$$$
SWF002807
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002807

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(C(C)C)CC2)c1

$$$$
SWF002808
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   11.6913   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002808

>  <SMILES>
CC1N(C)C(=O)COC12CCN(C(=O)CCc1cncnc1)CC2

$$$$
SWF002809
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.2058    5.3000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 17 18  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002809

>  <SMILES>
O=C(C1CC(O)C1)N1Cc2ccnn2CCC1CN1CCC(F)(F)C1

$$$$
SWF002810
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF002810

>  <SMILES>
Cn1nccc1C(=O)N1CCOC(c2cn3c(N4CCCC4)cccc3n2)C1

$$$$
SWF002811
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 15 18  2  0  0  0  0
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 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002811

>  <SMILES>
Cn1cc(-c2ncnc3c2CN(C(=O)C2CC(F)(F)C2)CC3)cn1

$$$$
SWF002812
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    0.1229    1.6691   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5296    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
  9 10  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002812

>  <SMILES>
CN1CC2(COCCN(c3ncnc4ccsc34)C2)CC1=O

$$$$
SWF002813
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.6291   -1.5409   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9381   -2.4920   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3201   -2.4920   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4480    0.1817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002813

>  <SMILES>
C=CCO[C@H]1CCN(C(=O)c2cccs2)[C@H]1Cc1ccncc1

$$$$
SWF002814
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  3  0  0  0  0
 19 22  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002814

>  <SMILES>
N#Cc1ccccc1CN1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF002815
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002815

>  <SMILES>
O=C(NC1CC1)C1(Nc2ccc(F)cn2)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF002816
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2500    0.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9843    4.9810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    4.9810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    6.4434   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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  7  8  1  0  0  0  0
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 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002816

>  <SMILES>
CC1(C)CC1C(=O)N1C[C@H]2CCN(c3ncccn3)CC[C@H]2C1

$$$$
SWF002817
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1409   -4.5473   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
 11  6  1  1  0  0  0
  7 12  3  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002817

>  <SMILES>
N#CC1(C(=O)N2C[C@@H]3[C@H](C2)OC[C@@H]3C(=O)N2CCCCO2)CCCC1

$$$$
SWF002818
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002818

>  <SMILES>
CCN1C(=O)CO[C@@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]21

$$$$
SWF002819
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
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 16 21  2  0  0  0  0
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 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF002819

>  <SMILES>
Cc1ccc(CN2CCO[C@H]3CN(C(=O)c4ccc5[nH]ccc5c4)C[C@H]32)o1

$$$$
SWF002820
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002820

>  <SMILES>
O=C(c1cnccn1)N1CCC(c2nnn3cc(-c4cccnc4)ccc23)C1

$$$$
SWF002821
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  1  0  0  0
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 25 28  1  0  0  0  0
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 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002821

>  <SMILES>
Cc1cc(C)nc(N2CC[C@H]3[C@@H]2CC(=O)N3Cc2ccc(OC(F)F)cc2)n1

$$$$
SWF002822
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.9826    7.6317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    9.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097    7.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462    9.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8363    7.1682   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002822

>  <SMILES>
COCCCN1CCCC2(CCCN(C(=O)c3sccc3F)C2)C1

$$$$
SWF002823
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.7551   -3.5996   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7061   -3.2905   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1673   -2.7905   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7061   -2.2905   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5152   -3.8783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4679   -0.8226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF002823

>  <SMILES>
COCc1cnc2n1CCN(C(=O)c1csc(C)n1)C2C

$$$$
SWF002824
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
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 21 22  2  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002824

>  <SMILES>
CCOCC1CCS(=O)(=O)C12CN(Cc1cccc3ccccc13)C2

$$$$
SWF002825
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  2  0  0  0  0
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 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002825

>  <SMILES>
Cc1cncc(CN2CC(F)(F)CC3(CCN(C)C3=O)C2)n1

$$$$
SWF002826
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7159   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF002826

>  <SMILES>
CCN1CCC2(CN(C(=O)c3ocnc3C)CC(F)(F)C2)C1=O

$$$$
SWF002827
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7978   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8467   -4.3909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1036   -3.7217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6388   -5.3690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8475   -4.0307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3122   -5.6780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5906   -3.3616   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 15  1  0  0  0  0
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 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002827

>  <SMILES>
O=C(c1cccc(O)c1)N1C[C@@H]2[C@@H](CN3CCCC3)CO[C@@H]2C1

$$$$
SWF002828
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -0.7929   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002828

>  <SMILES>
CN(C)CC1CCC2(CN(C(=O)c3cccc(O)c3)C2)OC1

$$$$
SWF002829
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8074   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7142   -3.3231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1264   -4.1321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002829

>  <SMILES>
Cc1cc(F)ccc1CC(=O)N1CC2(CC(CO)CN2C)C1

$$$$
SWF002830
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 13  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002830

>  <SMILES>
O=C(Cn1cnnn1)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF002831
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.1168    0.6443   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9033    1.5260   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7301   -0.2794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9503   -3.0200   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
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 11 14  1  0  0  0  0
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 20 21  1  6  0  0  0
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 22 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  1  0  0  0
 10 13  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002831

>  <SMILES>
CN(CC1CC2(CCN(S(=O)(=O)Cc3ccccc3)CC2)CO1)[C@H]1CC[C@H](O)CC1

$$$$
SWF002832
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002832

>  <SMILES>
O=C(c1ncc(F)cc1F)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002833
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002833

>  <SMILES>
O=C(C1CC(F)C1)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF002834
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6698    1.4115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4887    3.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6643    1.5160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  6  1  1  0  0  0
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 10 15  1  0  0  0  0
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  9 11  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002834

>  <SMILES>
CN(C)c1cccc(C(=O)N2C[C@H]3CC[C@@H]2[C@@H]3OCC2CC2)c1

$$$$
SWF002835
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.4709   -3.5993   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 21 23  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002835

>  <SMILES>
CC(C)NC(=O)C1CN(C(=O)C2(F)CCC2)CC12CCOCC2

$$$$
SWF002836
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 23 24  2  0  0  0  0
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 25 27  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002836

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(c3ccc(-c4ccoc4)cc3)CCOCC12

$$$$
SWF002837
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9128   -1.3956   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9128    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 23  2  0  0  0  0
 10 14  1  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002837

>  <SMILES>
C=CCOCC1CC2OCCN(C(=O)CC3(OC)CCC3)C2C1

$$$$
SWF002838
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 21  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002838

>  <SMILES>
C=CCOc1ccc(C(=O)N2CCC3(CCN(Cc4cccnc4)CC3)CC2)cc1

$$$$
SWF002839
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002839

>  <SMILES>
O=C(c1ccnc(F)c1)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF002840
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002840

>  <SMILES>
COC1(CC(=O)N2CCC3(CC2)c2ncccc2C(=O)N3C)CCC1

$$$$
SWF002841
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 14  1  0  0  0  0
 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002841

>  <SMILES>
O=C(CC1CCOCC1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002842
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF002842

>  <SMILES>
O=C(Cn1cnnn1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002843
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  1  0  0  0
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 16 20  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002843

>  <SMILES>
O=C(c1cc[nH]n1)N1CC[C@H]2OCC[C@@H](C(=O)N3CCCC3)[C@@H]2C1

$$$$
SWF002844
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 17  1  1  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002844

>  <SMILES>
O=C(NCc1cccnc1)[C@@H]1C[C@H]2OCC[C@H]2N(C(=O)c2cc[nH]n2)C1

$$$$
SWF002845
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF002845

>  <SMILES>
O=C1CC(C(=O)N2C[C@@H]3OCCN(c4ncccn4)[C@H]3C2)=CC=N1

$$$$
SWF002846
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
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 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
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 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF002846

>  <SMILES>
Cc1noc(CC(=O)N2CC(F)(F)CC3(CCN(C)C3=O)C2)n1

$$$$
SWF002847
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3527   -7.4230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002847

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)C4CC4(C)C)C[C@@H]32)cs1

$$$$
SWF002848
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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   -0.1565   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0382   -4.7095   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002848

>  <SMILES>
CCn1nccc1C(=O)N1C[C@@H]2OCCN(Cc3cccc(C)n3)[C@H]2C1

$$$$
SWF002849
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002849

>  <SMILES>
O=C(c1ccnnc1)N1Cc2cncn2C(COCC2CCCC2)C1

$$$$
SWF002850
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002850

>  <SMILES>
CN1CCOC2CN(C(=O)c3cnn4ccccc34)CCC2C1

$$$$
SWF002851
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002851

>  <SMILES>
Cc1cccc(CN2CCC3(CC4CCC3N4Cc3cccnc3)C2=O)n1

$$$$
SWF002852
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5701   -2.2788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 12 13  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002852

>  <SMILES>
CN(C)CC(=O)N1CCOC2(C1)C(=O)N(C)CC2c1ccccc1

$$$$
SWF002853
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  2  0  0  0  0
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 23 25  2  0  0  0  0
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  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002853

>  <SMILES>
O=C(C1CC1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)C1

$$$$
SWF002854
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF002854

>  <SMILES>
O=C1CCC2(CCN(Cc3cn[nH]c3)CC2)N1Cc1ccncc1

$$$$
SWF002855
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
 11  7  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002855

>  <SMILES>
Cn1cnc(S(=O)(=O)N2C[C@H]3CN(c4cccnc4)C(=O)[C@H]3C2)c1

$$$$
SWF002856
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.2945   -5.6833   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002856

>  <SMILES>
CS(=O)(=O)N1C[C@H]2CN(C(=O)CCc3ccccc3F)[C@H]2C1

$$$$
SWF002857
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.6308    0.0234   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002857

>  <SMILES>
Cn1ccc(NC(=O)C2(n3ccnc3)CCN(CC3CCCCC3)CC2)n1

$$$$
SWF002858
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF002858

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)CN(C)S(=O)(=O)c2cccnc2O3)s1

$$$$
SWF002859
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF002859

>  <SMILES>
CN1CCC(COc2ncccc2F)CC12CN(C(=O)c1cc3ccccc3[nH]1)C2

$$$$
SWF002860
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF002860

>  <SMILES>
CCOCC(=O)N1CC2(C1)OCCC2COc1ncccc1F

$$$$
SWF002861
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 19 22  1  6  0  0  0
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M  END
>  <HTSID>
SWF002861

>  <SMILES>
CN1C(=O)c2cccnc2C12CCN(C(=O)C1(C)CC=CCC1)CC2

$$$$
SWF002862
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002862

>  <SMILES>
Cc1ccccc1CN1CCCC(C(=O)N(C)C)(n2cccn2)C1

$$$$
SWF002863
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002863

>  <SMILES>
COc1cccc(CN2CC3(CC(OCC4CCOCC4)CS3)C2)c1

$$$$
SWF002864
Actelion Java MolfileCreator 1.0

 31 35  0  0  1  0  0  0  0  0999 V2000
    4.2343   -2.5611   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002864

>  <SMILES>
Cc1nc(CN2CCC[C@]3(CN(Cc4ccccn4)C[C@H]3c3ccnn3C)C2=O)cs1

$$$$
SWF002865
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002865

>  <SMILES>
Cc1cc(C)cc(CN2CC3(CCC(CNS(=O)(=O)C4CC4)CO3)C2)c1

$$$$
SWF002866
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002866

>  <SMILES>
CCOCC1CCN(C)C2(C1)CN(C(=O)c1cccc(C#N)c1)C2

$$$$
SWF002867
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002867

>  <SMILES>
Cn1cc(C2CN(C(=O)NC3CC3)CCC2N2CCCCC2)cn1

$$$$
SWF002868
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    4.9784   -1.4750   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  7 10  1  0  0  0  0
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 25 27  2  0  0  0  0
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 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002868

>  <SMILES>
c1ccc(CN2CCC(c3nc4ccc(-c5ccccc5)cn4n3)C2)cc1

$$$$
SWF002869
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6  9  1  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
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 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002869

>  <SMILES>
Cc1cc(C(=O)N2CC(F)(F)CC3(CCN(C)C3=O)C2)cc(C)n1

$$$$
SWF002870
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002870

>  <SMILES>
CCC(CC)NC(=O)C1CC2(CO1)CN(Cc1cnn(CC)c1)CCO2

$$$$
SWF002871
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002871

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(Cc2ccccc2C)CC1

$$$$
SWF002872
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002872

>  <SMILES>
O=C(c1cccs1)N1C[C@@H]2CN(C(=O)C3(F)CCC3)C[C@@H]2C1

$$$$
SWF002873
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002873

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF002874
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002874

>  <SMILES>
Cc1cccnc1C(=O)N1CCC2CC21C(=O)NCc1cccnc1

$$$$
SWF002875
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002875

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(S(=O)(=O)c4ccc5c(c4)OCCO5)C[C@@H]32)cs1

$$$$
SWF002876
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002876

>  <SMILES>
Cc1c(C(=O)N2CCc3nc(C(=O)N(C)C)sc3CC2)nc2ccccn12

$$$$
SWF002877
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002877

>  <SMILES>
COCCNC(=O)c1cn2c(n1)C(C)N(C(=O)c1c[nH]c3ccccc13)CC2

$$$$
SWF002878
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    8.2350   -0.1340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2350   -3.5981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002878

>  <SMILES>
CC(C)CC(=O)N1CCn2cc(C(=O)NC(C)C)nc2C1C

$$$$
SWF002879
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.1423    2.4510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6058    6.1317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1788    6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1423    7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002879

>  <SMILES>
Cn1cnc(S(=O)(=O)N2CCC3(CCC(CC(=O)N4CCCC4)CC3)CC2)c1

$$$$
SWF002880
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0622   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  1  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002880

>  <SMILES>
Cc1cccc(CN2CCC3(CCC(CNC(=O)Cc4ccccc4)OC3)CC2)c1

$$$$
SWF002881
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3163   -2.7715   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1253   -1.3702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2298   -2.3647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0959   -2.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0959   -3.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9049   -4.4525   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2868   -4.4525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5959   -5.4036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8559   -4.1435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5959   -5.4036   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF002881

>  <SMILES>
Cn1cncc1CN1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF002882
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4413    6.7418   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2278    4.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9741    7.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2241    5.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3640    8.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF002882

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)COCCN3CC2CC2)o1

$$$$
SWF002883
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002883

>  <SMILES>
CN(C)CC1CCC2(COCCN(C(=O)Cc3ccc(F)cn3)C2)O1

$$$$
SWF002884
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.0530   -0.9659   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2942    0.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  6  0  0  0
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 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002884

>  <SMILES>
Cn1nnc2c1C(COCCN1CCCC1)CN(C(=O)C1(F)CC1)C2

$$$$
SWF002885
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.3585    2.5132   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002885

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)CC3(O)CCC3)CCC21

$$$$
SWF002886
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 14  2  0  0  0  0
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 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002886

>  <SMILES>
C=CCOC1C2CCCC1CN(C(=O)CCc1cncnc1)C2

$$$$
SWF002887
Actelion Java MolfileCreator 1.0

 34 39  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 22 27  1  0  0  0  0
 24 28  2  0  0  0  0
 25 29  2  0  0  0  0
 27 30  1  0  0  0  0
 27 31  1  0  0  0  0
 30 32  1  0  0  0  0
 31 33  1  0  0  0  0
 32 34  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 23 26  1  0  0  0  0
 28 29  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <HTSID>
SWF002887

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2ccnc(N3CCOCC3)c2)N1Cc1ccc(-n2cccn2)cc1

$$$$
SWF002888
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002888

>  <SMILES>
CN1CCO[C@@H]2CN(C(=O)c3ccc4c(ccn4C)c3)C[C@@H]2C1

$$$$
SWF002889
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  6  2  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002889

>  <SMILES>
CN1CCOC2CN(C(=O)c3ncc(Cl)cn3)CCC2C1

$$$$
SWF002890
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002890

>  <SMILES>
O=C(c1ccccc1)N1CCc2ncnc(N3CCOCC3)c2CC1

$$$$
SWF002891
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
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 10 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002891

>  <SMILES>
O=C(c1cc[nH]n1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF002892
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002892

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CC2)C1

$$$$
SWF002893
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.0963    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002893

>  <SMILES>
O=C(NCc1cccnc1)[C@@H]1C[C@H]2OCC[C@H]2N(C(=O)C2(F)CC2)C1

$$$$
SWF002894
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF002894

>  <SMILES>
CCc1ccc(C(=O)N2CCC3OCCCC3(COC)C2)cn1

$$$$
SWF002895
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.8584    1.6906   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.8024    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF002895

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)C4(F)CC4)C3)C2=O)n1

$$$$
SWF002896
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
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 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF002896

>  <SMILES>
Cn1cccc1CN1C[C@@H]2CN(C(=O)c3cccnc3)C[C@@H]2C1

$$$$
SWF002897
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002897

>  <SMILES>
O=C(NC1CCCC1)c1nnc2n1CCCN(C(=O)c1cc[nH]n1)C2

$$$$
SWF002898
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002898

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2cnccn2)CC1

$$$$
SWF002899
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002899

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCC2(CCCN(c3ncccn3)C2)CC1

$$$$
SWF002900
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002900

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)c3cccc(C)c3)C2)CN1C

$$$$
SWF002901
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  2  0  0  0  0
 16 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 17  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002901

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCCN(C(=O)C(C)C)C1

$$$$
SWF002902
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352    1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -1.5146   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -3.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0040   -0.0187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0720   -2.1307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352   -4.5439   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3281    0.3066   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0855   -1.0051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -3.7866   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5586   -4.5439   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8703   -3.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1820   -4.5439   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8703   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4938   -3.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1820   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4938   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002902

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(Cc2ccccn2)CC1

$$$$
SWF002903
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002903

>  <SMILES>
Cc1cccc(CN2CCC(Nc3ccccc3)(C(=O)N(C)C)CC2)c1

$$$$
SWF002904
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.0189    2.5274   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6953    1.7909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3956    0.8368   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    2.0084   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4068    0.6878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3478    1.2719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9710    2.9624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8762   -0.1011   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3238    1.4894   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9471    3.1800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2722   -1.1091   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  2  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002904

>  <SMILES>
C=CCOC1C2CCC1N(C(=O)c1ccc(C)nc1)CCO2

$$$$
SWF002905
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.2033   -5.1335   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.5932   -3.7631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4749   -2.5496   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1014   -3.6063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8648   -1.1793   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4913   -2.2360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9996   -2.0792   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7629    0.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9847    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0502    2.6065   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9810    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5137    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  5  7  2  0  0  0  0
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  7  9  1  0  0  0  0
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  9 11  1  0  0  0  0
 12 11  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  1  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002905

>  <SMILES>
CCO[C@H]1CN(C(=O)c2cnc(Cl)cc2Cl)[C@@H]2CCCO[C@H]12

$$$$
SWF002906
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -1.3113   -6.0568   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7855   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -2.2713   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340   -1.5142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3173   -2.1301   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2418   -0.0161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6351    0.0157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3305   -1.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5734    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002906

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2ccccn2)CC1

$$$$
SWF002907
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -1.3113   -6.0568   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7855   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340   -1.5142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3173   -2.1301   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2418   -0.0161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6351    0.0157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3305   -1.0048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5734    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002907

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2ccccc2)CC1

$$$$
SWF002908
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.9757    2.4067   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.6636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    0.7976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002908

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(Cc2cccs2)CC1

$$$$
SWF002909
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6750   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0570   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3660   -5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3660   -5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002909

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF002910
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.6258   -0.1412   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6386   -1.2659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4013   -2.2620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8818   -2.5767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108    1.5136   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7568   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3108    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3108   -3.0271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9323   -3.0271   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3150   -2.4115   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2398   -4.5220   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6341   -4.5641   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3108   -4.5407   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3278   -3.5363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5710   -4.8470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3108   -6.0542   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002910

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)/C=C/c2cccs2)CC1

$$$$
SWF002911
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0052    4.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3871    4.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6962    5.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6962    5.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1084    5.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002911

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(Cc2cnn(C)c2)CC1

$$$$
SWF002912
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -1.3118   -6.0591   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3118   -4.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7870   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6237   -3.7870   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3118   -4.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2722   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7820   -2.2805   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0075   -4.4031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6237   -3.7870   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3118   -1.5148   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2637   -1.9655   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0211   -3.2774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6237   -0.7574   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2434   -0.0161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6365    0.0157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3118   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3329   -1.0052   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5755    0.3066   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3118    1.5148   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7574   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002912

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)C2=CCCC2)CC1

$$$$
SWF002913
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1621   -1.7588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4550   -0.5341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -0.7929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002913

>  <SMILES>
O=C(C1CCC1)N1CCC(Nc2ccccc2)(C(=O)N2CCC2)CC1

$$$$
SWF002914
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.2401   -0.7563   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5615   -0.7720   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601   -2.2690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601    0.7563   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501    3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2401    0.7563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1702   -3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1676   -0.7402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2420    1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2401    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9301    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1702   -4.5381   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4979   -1.0626   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2542    0.2475   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9301    3.0254   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4802   -5.2944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6200    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100    3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3100    3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.7563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3100    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6200    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002914

>  <SMILES>
COCCNC(=O)C1(n2ccnc2)CCN(Cc2cccc(C)c2)CC1

$$$$
SWF002915
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   15.7242    0.7565   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   14.4139    1.5131   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4139    3.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1035    0.7565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1035    3.7827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7932    1.5131   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7932    3.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4828    3.7827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1725    3.0261   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8621    3.7827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1725    1.5131   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5518    3.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8621    0.7565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5518    1.5131   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2414    0.7565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5518   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8591    1.3719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9340   -0.7379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5395   -0.7800   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8621   -0.7565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8467    0.2475   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6032   -1.0628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1725   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4828   -0.7565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7932   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.1035   -0.7565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002915

>  <SMILES>
COCCNC(=O)C1(n2ccnc2)CCN(Cc2ccc(Cl)cc2)CC1

$$$$
SWF002916
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -2.6183   -1.2273   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6750   -2.6799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0024   -1.5906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7840   -3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8410   -1.0460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0547   -2.5893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8885   -2.4877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002916

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccc2C)C1

$$$$
SWF002917
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002917

>  <SMILES>
O=C(c1ccsc1)N1CCC(Nc2ccccc2)(C(=O)N2CCC2)CC1

$$$$
SWF002918
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002918

>  <SMILES>
O=C(c1ccccn1)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF002919
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.0020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
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 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002919

>  <SMILES>
CCc1ccc(C(=O)N2CC3(C2)CN(C)c2nccnc23)cn1

$$$$
SWF002920
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.0403    1.7803   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8653    2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8653    3.7842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5544    1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5544    4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8653    0.7568   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2435    2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5544    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5544    6.0547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2435    3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0235   -0.7485   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3160    1.2392   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9326    1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2435   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2435    6.8115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9326    4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5041   -1.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2610    0.2476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6218   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -2.2705   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109    1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002920

>  <SMILES>
CC(C)C(=O)N1CCC(C(=O)Nc2ccccc2)(n2cccn2)CC1

$$$$
SWF002921
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.2401   -0.7563   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5615   -0.7720   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601   -2.2690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601    0.7563   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501    3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2401    0.7563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1702   -3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1676   -0.7402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2420    1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2401    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9301    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1702   -4.5381   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4979   -1.0626   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2542    0.2475   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9301    3.0254   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4802   -5.2944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6200    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100    3.0254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3100    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3100    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002921

>  <SMILES>
COCCNC(=O)C1(n2ccnc2)CCN(Cc2ccccc2C)CC1

$$$$
SWF002922
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.1449    0.7976   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.6636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757    2.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002922

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(C(=O)c2cscn2)CC1

$$$$
SWF002923
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.6201   -0.7564   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3101   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3101    1.5127   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6201    2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3101    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6201    3.7818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6201   -0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6201   -2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9302    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    5.2945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1677    7.0654   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1629    6.5565   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3101    4.5382   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5537    8.3787   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002923

>  <SMILES>
Cc1cccc(C(=O)N2CCC(C(=O)N3CCC3)(n3cccn3)CC2)c1

$$$$
SWF002924
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF002924

>  <SMILES>
Cn1cnc(C(=O)N2CCCn3ncc(C(=O)N4CCCC4)c3C2)n1

$$$$
SWF002925
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    5.2812    1.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002925

>  <SMILES>
O=C(c1noc2c1CC(NCC1CCOCC1)CC2)N1CCCC1

$$$$
SWF002926
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
    5.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 28  1  0  0  0  0
  9  7  1  1  0  0  0
 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
 20 23  1  0  0  0  0
 26 28  2  0  0  0  0
M  END
>  <HTSID>
SWF002926

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2[C@H](C1)n1cccc1C(=O)N2Cc1ccccc1

$$$$
SWF002927
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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M  END
>  <HTSID>
SWF002927

>  <SMILES>
CC(=O)c1cc(C(=O)N2CCc3ncnc(N4CCN(C)CC4)c3CC2)n[nH]1

$$$$
SWF002928
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 10 16  1  0  0  0  0
 11 13  2  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002928

>  <SMILES>
Cc1nc2ccccn2c1C(=O)N1CCC2CN(C)CCOC2C1

$$$$
SWF002929
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 22  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002929

>  <SMILES>
CC(C)N1C[C@@H](C(=O)NCc2cccnc2)C[C@H]2OCC[C@H]21

$$$$
SWF002930
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 28 31  1  0  0  0  0
  9 12  1  0  0  0  0
 15 17  1  0  0  0  0
 20 22  2  0  0  0  0
 24 26  2  0  0  0  0
 29 31  2  0  0  0  0
M  END
>  <HTSID>
SWF002930

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC(c2nnc3ccc(-c4ccnn4C)nn23)CC1

$$$$
SWF002931
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1383   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9508   -5.7501   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 14 15  1  6  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002931

>  <SMILES>
c1cncc(OC2CSC3(C2)CN(Cc2ccsc2)C3)c1

$$$$
SWF002932
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2299   -2.7949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2299   -2.7949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF002932

>  <SMILES>
COCC1CCN(C)C2(C1)CN(C(=O)c1n[nH]c3c1CCC3)C2

$$$$
SWF002933
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.4729   -8.1174   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8432   -7.5072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF002933

>  <SMILES>
CCOCCC1CCOC12CCN(Cc1ccsc1)CC2

$$$$
SWF002934
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7346    2.6853   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 26  2  0  0  0  0
 23 27  1  0  0  0  0
 24 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 22 26  1  0  0  0  0
 23 25  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002934

>  <SMILES>
O=C(c1c[nH]c2ccccc12)N1CC2(C1)C(COc1ccccn1)CCS2(=O)=O

$$$$
SWF002935
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 19 20  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002935

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC1)OCCC2CCOc1ccccn1

$$$$
SWF002936
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  7  8  1  0  0  0  0
 17 19  1  0  0  0  0
 22 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002936

>  <SMILES>
Cc1cc(S(=O)(=O)N2CCCC3(CCCN(c4ncccn4)C3)C2)c(C)cc1Cl

$$$$
SWF002937
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002937

>  <SMILES>
Cc1csc(C(=O)N2CCC3(CC2)CN(Cc2nccs2)CCO3)c1

$$$$
SWF002938
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3912   -9.7260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8547  -11.1525   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002938

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(Cc3cn[nH]c3)C2)C1

$$$$
SWF002939
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0461    2.1333   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1696    0.1874   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0017    2.4281   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5600    1.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6939    3.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  2  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 19 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002939

>  <SMILES>
COc1cccc(NC(=O)c2nc3c(s2)CCN(C(C)C)CC3)c1

$$$$
SWF002940
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9843    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8658   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5448    4.8981   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2041    6.0253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    7.3768   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4859    8.5040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8157   11.2069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6801   11.0949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 16 18  1  0  0  0  0
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 19 21  1  0  0  0  0
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 11 12  2  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002940

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CC2)CN(c2ccccn2)CCO3)o1

$$$$
SWF002941
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  1  0  0  0  0
 16 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 12  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002941

>  <SMILES>
Cn1cc(-c2ncnc3c2CN(C(=O)CCc2ccc[nH]2)CC3)cn1

$$$$
SWF002942
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8539   -6.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  6  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
 10 14  1  0  0  0  0
 13 16  1  0  0  0  0
 19 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002942

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(OC)c1ccc(C)cc12

$$$$
SWF002943
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.6494   -4.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6275   -4.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8185   -3.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002943

>  <SMILES>
CCc1ccc(C(=O)N2CCc3ncnc(-c4ccsc4)c3C2)cn1

$$$$
SWF002944
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002944

>  <SMILES>
CC(=O)c1cc(C(=O)N2CCC3(CCCCN3C)CC2)n[nH]1

$$$$
SWF002945
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1383   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3074   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8019   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3897   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3897   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0807   -3.1991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8897   -3.7868   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002945

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CC2(CCN(C(=O)c3ccoc3)C2)C1

$$$$
SWF002946
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    1.2990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1362   -1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1362   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0333   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4352   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -8.5607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002946

>  <SMILES>
O=S(=O)(NC1CC2(CCN(Cc3ccncc3)CC2)C1)C1CC1

$$$$
SWF002947
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4289    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002947

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF002948
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.0353    5.3460   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2853    4.0470   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002948

>  <SMILES>
Cn1cnc(S(=O)(=O)N2CCC3(CCC3NC(=O)c3cccn3C)CC2)c1

$$$$
SWF002949
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3202   -4.0536   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6192   -3.3036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.3692   -0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0702    0.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5665   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8  9  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002949

>  <SMILES>
CN(Cc1ccccn1)C(=O)[C@@H]1C[C@@H]2CCN(S(=O)(=O)C3CC3)C[C@H]2O1

$$$$
SWF002950
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002950

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCN(C(=O)COC)CC1

$$$$
SWF002951
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684    3.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549    5.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    4.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221    5.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322    6.9240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505    8.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4587    7.9807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  6  0  0  0
  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002951

>  <SMILES>
O=C(C1CC1)N1CCC[C@@]2(C[C@@H](Oc3ccccn3)CO2)C1

$$$$
SWF002952
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.5191   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1883   -2.7601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1664   -2.9680   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8793   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8356   -2.2248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4670   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8137   -2.4328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5265   -1.2738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8793   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4828   -1.6896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1957   -0.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1738   -0.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002952

>  <SMILES>
COCCNC(=O)C1CCc2c(C(=O)NC3CCCCC3)ncn2C1

$$$$
SWF002953
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452   -5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452   -5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -4.0537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2341   -5.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002953

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(S(=O)(=O)c2ccccc2)CC1

$$$$
SWF002954
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002954

>  <SMILES>
O=C(N1CCC2(CCN(Cc3cccnc3)CC2)CC1)C1(F)CCC1

$$$$
SWF002955
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002955

>  <SMILES>
O=C(N1CCOC2(CCCN(c3ccccn3)C2)C1)C1(F)CCC1

$$$$
SWF002956
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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    6.4871    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7655    2.4982   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5575    3.4764   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9781   -0.7079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 20 17  1  1  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  6  0  0  0
 23 25  1  6  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002956

>  <SMILES>
COc1ccc(N2CC3(CCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3)CC2=O)cc1

$$$$
SWF002957
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7978   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9193   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0377   -3.8031   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5377   -5.3419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7713   -4.3909   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0501   -6.1509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  2  0  0  0  0
 11 12  1  0  0  0  0
 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002957

>  <SMILES>
Cn1nc(Cn2cccc2)c2c1CN(C(=O)c1cc(C3CC3)on1)C2

$$$$
SWF002958
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4836    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 22 26  2  0  0  0  0
 24 27  2  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002958

>  <SMILES>
c1ccc(CN2CCC3(CC2)OCCC3CCOCc2cccnc2)nc1

$$$$
SWF002959
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002959

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2OCCN(CC3CCCO3)C2C1

$$$$
SWF002960
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002960

>  <SMILES>
CC(C)C(=O)NC1COC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF002961
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5738    0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF002961

>  <SMILES>
CN1CC(C(=O)NCc2ccco2)OC2(CCN(C(=O)c3ccco3)CC2)C1

$$$$
SWF002962
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    0.5214   -2.4351   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8336   -3.9041   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9904   -2.1229   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4835   -1.3191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.9525   -1.6313   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0194    0.1092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3006   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7083    1.7958   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  2  0  0  0  0
 10 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002962

>  <SMILES>
O=C(N1CCCC1)C12CC1CCN2S(=O)(=O)c1ccc2c(c1)CCO2

$$$$
SWF002963
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002963

>  <SMILES>
O=C(Nc1ccc(F)c(F)c1)N1CCCC2(CCCN(Cc3cccnc3)C2)C1

$$$$
SWF002964
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002964

>  <SMILES>
Cc1cccnc1C(=O)N1CCCC2(CCCN(Cc3ccnn3C)C2)C1

$$$$
SWF002965
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF002965

>  <SMILES>
Cc1csc(C(=O)N2CCCC3(CCCN(c4ncccn4)C3)C2)c1

$$$$
SWF002966
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 19 21  1  6  0  0  0
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  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002966

>  <SMILES>
O=C(Cc1ccc(O)cc1)N1CCC2(CC1)COC(CN1CCCC1)C2

$$$$
SWF002967
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 26 29  2  0  0  0  0
  6  8  1  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002967

>  <SMILES>
Cc1ccccc1C(=O)N1CC(C(=O)Nc2cccc(F)c2)C2(CCOCC2)C1

$$$$
SWF002968
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002968

>  <SMILES>
O=C(c1ccoc1)N1CC2C(C1)n1cccc1C(=O)N2Cc1ccccn1

$$$$
SWF002969
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 14  1  0  0  0  0
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 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
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 18 21  1  0  0  0  0
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 10 16  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002969

>  <SMILES>
Cc1cccnc1C(=O)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF002970
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0206    4.8650   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4105    6.2353   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2921    7.4488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6820    8.8192   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7839    7.2920   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6656    8.5056   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1656    8.5056   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2021    9.9322   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6291    9.9322   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4156   10.8138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0557   10.3957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF002970

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)Cc3ccn(C)n3)CC2)O1

$$$$
SWF002971
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -8.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2278   -7.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2241   -8.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002971

>  <SMILES>
Cc1ccc(CN2CCOC3(CCN(C(=O)c4cc[nH]n4)CC3)C2)cc1

$$$$
SWF002972
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    5.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    5.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    6.8083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    6.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3326    8.0218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4894    9.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7030    8.6319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 19 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002972

>  <SMILES>
COCC12CCCOC1CCN(C(=O)c1cc(C3CC3)on1)C2

$$$$
SWF002973
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   11.1758   -2.0893   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.6910   -3.5088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1930   -6.0579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.1800   -7.1875   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.1365   -5.4782   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 12 17  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF002973

>  <SMILES>
CCc1ccc(C(=O)N2CCOCC3(CC(CN(C)C(C)C)CO3)C2)cn1

$$$$
SWF002974
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468   -4.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.6570   -4.0204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0097   -4.5556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9660   -4.9714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3187   -5.5067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002974

>  <SMILES>
c1ccc(Nc2ncnc3c2nnn3CC2CN(Cc3ccoc3)CCO2)cc1

$$$$
SWF002975
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.6451   -2.5092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3461   -1.7592   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3040    0.7363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9922    2.2035   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8453    1.2764   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1069    3.2072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5335    2.7436   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6482    3.7473   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1362   -2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002975

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)C4CC(C)C4)C3)CC2=O)cc1

$$$$
SWF002976
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.4955   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2462    0.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1635    1.4854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF002976

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)CCc4ccc[nH]4)C3)CC2=O)cn1

$$$$
SWF002977
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF002977

>  <SMILES>
O=C(c1ccncc1)N1CCCC2(CCCN2Cc2cccc(F)c2)CC1

$$$$
SWF002978
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.5984    1.3640   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1862    2.1730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7795    3.0865   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002978

>  <SMILES>
CNC(=O)C1CCCC12CCN(C(=O)Cc1ccc(C)cc1)C2

$$$$
SWF002979
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF002979

>  <SMILES>
Cc1ccc(CN2C(=O)CCC23CCCN(Cc2cncn2C)CC3)cc1

$$$$
SWF002980
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002980

>  <SMILES>
O=C(c1ccsc1)N1CC2OCCN(Cc3cccnc3)C2C1

$$$$
SWF002981
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
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 18 21  1  0  0  0  0
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 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 12 17  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF002981

>  <SMILES>
COc1cccc(C(=O)N2CCCC3(CCCN(CC4CC4)C3)C2)n1

$$$$
SWF002982
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF002982

>  <SMILES>
CCN1CCC2(CCN(C(=O)Cc3ccc(C)cc3)CC2)CC1=O

$$$$
SWF002983
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.2288   -5.0048   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF002983

>  <SMILES>
CCOCCC1CCOC12CCN(Cc1ccc(C)o1)CC2

$$$$
SWF002984
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.8695   -5.3885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF002984

>  <SMILES>
COCCNC(=O)c1ccc2n1CCN(C(=O)c1cc[nH]c1)CC2

$$$$
SWF002985
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1682    4.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF002985

>  <SMILES>
Cn1cnc(C(=O)N2CCCC3(CCCN(Cc4cccnc4)C3)C2)c1

$$$$
SWF002986
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 14 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF002986

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(CCN(S(=O)(=O)C3CC3)C2)C1

$$$$
SWF002987
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  2  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 27 29  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF002987

>  <SMILES>
COc1ccc(CN2CCC3(CCc4cc(-c5cccnc5)ccc43)CC2)cc1

$$$$
SWF002988
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
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M  END
>  <HTSID>
SWF002988

>  <SMILES>
Cc1cncc(CN2Cc3ccnn3CCC2COc2ccccn2)n1

$$$$
SWF002989
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.6915    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  8  1  0  0  0  0
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 10 11  2  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF002989

>  <SMILES>
O=C(NCCN1CCNC1=O)C1=NOC2(CCCN(Cc3ccccc3)C2)C1

$$$$
SWF002990
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF002990

>  <SMILES>
O=C1CC(C(=O)N2CC3(CC(NCC4CC4)CS3)C2)=CC=N1

$$$$
SWF002991
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF002991

>  <SMILES>
CN1CCCC12CCCN(C(=O)Cc1cccc(O)c1)CC2

$$$$
SWF002992
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 21  1  0  0  0  0
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M  END
>  <HTSID>
SWF002992

>  <SMILES>
COCC12CCCOC1CCN(C(=O)CCc1ccc[nH]1)C2

$$$$
SWF002993
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.3461   -2.0092   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  8  1  6  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF002993

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC(=O)N(c4ccsc4)C3)C2)C1

$$$$
SWF002994
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF002994

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(C(=O)c3cc[nH]c3)C2)C1

$$$$
SWF002995
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002995

>  <SMILES>
CCc1ccc(C(=O)N2CCCn3cnc(C(=O)NCC(C)C)c3C2)cn1

$$$$
SWF002996
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002996

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CCN(Cc3nccs3)C2)CC1

$$$$
SWF002997
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF002997

>  <SMILES>
COc1ccc(CNC(=O)C2Cn3ccnc3C3(CCN(CC4CCCC4)CC3)O2)cc1

$$$$
SWF002998
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF002998

>  <SMILES>
Cc1cc(CN2CCCC3(CCCN3C(=O)c3snnc3C)CC2)n(C)n1

$$$$
SWF002999
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF002999

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)Cc3ccccn3)CC2)C1)c1cscn1

$$$$
SWF003000
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003000

>  <SMILES>
CN1CCCCC12CCN(C(=O)Cc1ccc(F)cn1)CC2

$$$$
SWF003001
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003001

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1C2CCC1CN(Cc1cccnc1)C2

$$$$
SWF003002
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003002

>  <SMILES>
O=C1COC2(COCCN(C(=O)c3cc[nH]c3)C2)CN1CC1CC1

$$$$
SWF003003
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 25 26  1  0  0  0  0
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 12 15  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003003

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(=O)N(CC2CCC2)C3)cn1

$$$$
SWF003004
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
    6.2119    0.0782   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF003004

>  <SMILES>
O=C(C1CCCCC1)N1CCC2(CC1)Cc1ccccc1CN(Cc1ccncc1)C2=O

$$$$
SWF003005
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 10 13  1  0  0  0  0
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 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003005

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CCN(Cc3cccnc3)CC2)CC1

$$$$
SWF003006
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003006

>  <SMILES>
Cc1csc(C(=O)N2CCc3ncnc(-c4ccsc4)c3C2)c1

$$$$
SWF003007
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    0.0059   -3.9992   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7001   -4.3593   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4099   -5.9555   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2843   -6.3156   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2354   -6.0066   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3943   -4.7194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6022   -3.7413   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8112   -3.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003007

>  <SMILES>
O=C(NCc1cnc2n1CCN(Cc1ccc(F)c(F)c1)CC2)C1CCC1

$$$$
SWF003008
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.9641    0.3660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0772   -1.8070   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2630   -4.8340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6697   -3.9204   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003008

>  <SMILES>
O=C(NCC(F)(F)F)C1CC2(CO1)CN(Cc1ccncc1)CCO2

$$$$
SWF003009
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 11  1  6  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003009

>  <SMILES>
CCS(=O)(=O)N1CCC(C2CCCCN2Cc2cccc(F)c2)CC1

$$$$
SWF003010
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003010

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cnn(C)c2)CC1

$$$$
SWF003011
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6654   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 15 13  1  1  0  0  0
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 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
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 20 21  1  0  0  0  0
  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003011

>  <SMILES>
CCN1C[C@@H]2CN(C(=O)c3cccc(Cl)c3C)C[C@@H]2C1=O

$$$$
SWF003012
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.2242    1.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5464    3.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003012

>  <SMILES>
O=C(CC1(O)CCC1)N1CCCC2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF003013
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8288   -4.6084   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 18  2  0  0  0  0
M  END
>  <HTSID>
SWF003013

>  <SMILES>
Cc1ncnc(C(=O)N2C[C@@H]3C(C(=O)N(C)C)=NO[C@@H]3C2)c1C

$$$$
SWF003014
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    4.2109    3.8010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
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 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003014

>  <SMILES>
CN1C[C@@H](COCc2cccnc2)[C@]2(CCN(C(=O)C3[C@H]4COC[C@@H]34)C2)C1

$$$$
SWF003015
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5349    1.9042   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003015

>  <SMILES>
O=C(c1cnccn1)N1CCCC2(CCN(Cc3ccoc3)C2)C1

$$$$
SWF003016
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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   -2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003016

>  <SMILES>
O=C(N1CCOC2(CCCN(c3ccccc3)C2)C1)C1(F)CCC1

$$$$
SWF003017
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9535    1.6160   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.8671    1.2092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0400    2.0227   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603    2.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003017

>  <SMILES>
CS(=O)(=O)N1CCC2(CCCN(C(=O)c3cccnc3)C2)C1

$$$$
SWF003018
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4048    1.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752    0.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  6  9  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003018

>  <SMILES>
Cc1ccc(CN2Cc3ncn(C)c3C(C(=O)N3CCC3)C2)cc1

$$$$
SWF003019
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    8.2808    5.1689   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4718    5.7567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718    4.2179   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6628    5.1689   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4718    6.7567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9718    4.2179   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3840    3.4089   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3895    3.5134   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7907    2.4953   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2030    1.6863   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6097    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003019

>  <SMILES>
COCCNC(=O)c1cnc2n1C(CNC(=O)c1csc(C)n1)CC2

$$$$
SWF003020
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -4.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003020

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF003021
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003021

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C2CC2)CC1

$$$$
SWF003022
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    1.2990    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116    6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846    6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481    7.5583   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003022

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccoc2)CC1

$$$$
SWF003023
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527    2.8966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6926    4.5908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  6  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003023

>  <SMILES>
CCn1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N(C)Cc3ccccc3)C2)cn1

$$$$
SWF003024
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0024   -1.5906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7840   -3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8410   -1.0460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2354   -5.4218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003024

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cccc(C)c2)C1

$$$$
SWF003025
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -6.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  1  6  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 23 26  2  0  0  0  0
 25 27  1  0  0  0  0
 12 16  1  0  0  0  0
 14 19  1  0  0  0  0
 15 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003025

>  <SMILES>
COc1cccc(CN2C[C@H](C(=O)Nc3cccnc3)[C@@H]3CCO[C@@H]3C2)c1

$$$$
SWF003026
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  5 10  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003026

>  <SMILES>
COc1cccc(CN2C[C@@H](C)[C@@]3(CCN(c4cccnc4)C3=O)C2)c1

$$$$
SWF003027
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    3.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    4.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003027

>  <SMILES>
O=C(N1CCCC1)N1C[C@@H]2COC[C@]2(COc2ccccn2)C1

$$$$
SWF003028
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.0333   -1.8107   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7832   -3.1097   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
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 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 23 27  1  0  0  0  0
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 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003028

>  <SMILES>
Cc1noc(C)c1CN1CC[C@@H]2[C@@H](CO[C@H]2CC(=O)NC2CS(=O)(=O)C2)C1

$$$$
SWF003029
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3114   -7.7361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003029

>  <SMILES>
CNC(=O)C[C@@H]1OC[C@H]2CN(Cc3cccc(C)c3)CC[C@H]21

$$$$
SWF003030
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   12.0984    3.8011   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.2167    5.0147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8268    6.3850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7249    4.8579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9451    7.5985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8432    6.0714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4533    7.4417   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3514    5.9146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4698    7.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7413    4.5443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2496    4.3875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230    3.3308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003030

>  <SMILES>
CN(C)C(=O)C1OC2(CCN(C(=O)c3ccnc(F)c3)CC2)c2ccccc21

$$$$
SWF003031
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    2.1255   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    3.7435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  6  0  0  0
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 14 10  1  1  0  0  0
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 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003031

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@H]3C[C@H](C(=O)Nc4cccnc4)O[C@H]3C2)n1

$$$$
SWF003032
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
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 18 21  2  0  0  0  0
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 23 25  2  0  0  0  0
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 10 15  1  0  0  0  0
 13 17  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003032

>  <SMILES>
COc1cnccc1C(=O)N1CCc2ncnc(-c3cccnc3)c2C1

$$$$
SWF003033
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    4.2730   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5298   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003033

>  <SMILES>
O=C(NCc1cccnc1)C1=NO[C@@H]2CN(C(=O)c3ccccc3)C[C@H]12

$$$$
SWF003034
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
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 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003034

>  <SMILES>
Cc1cc(C)cc(C(=O)N2C[C@H](C(=O)N(C)C)C3OCCC32)c1

$$$$
SWF003035
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003035

>  <SMILES>
CS(=O)(=O)N1CCCCC1C1CCN(C(=O)c2ccsc2)CC1

$$$$
SWF003036
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  2  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003036

>  <SMILES>
Cc1cccc(-c2cnc3n2CCN(C(=O)c2ccc(F)cc2)C3)c1

$$$$
SWF003037
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5000   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000    0.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -3.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2321   -4.7709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7321   -2.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003037

>  <SMILES>
CC(C)(O)CC(=O)N1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF003038
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.4507    1.4057   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1417    0.4546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1635    0.2467   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8108   -0.2885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4944    0.9898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8545   -0.7044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5018   -1.2396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7890   -0.0806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5163    0.7819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8764   -0.9123   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1709   -1.9827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4581   -0.8238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2072   -0.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1491   -1.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8005   -1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2562    1.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8060   -0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8549    0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  1  0  0  0
 16 20  1  0  0  0  0
 18 21  1  6  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003038

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCN(C(=O)c4ccc(C)nc4)CC3)[C@@H]1CN(C)C2

$$$$
SWF003039
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5139    0.1235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4888   -0.0990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5139   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9227   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4888   -1.9010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1123   -2.6828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1011   -2.5338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7470   -3.6137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003039

>  <SMILES>
CC(C)N1CCOC2CN(C(=O)c3cccc(Cl)n3)CCC2C1

$$$$
SWF003040
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.6617   -3.7751   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.7764   -4.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0883   -3.3116   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1982   -2.3486   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6580   -4.8899   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7310   -2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1908   -4.5780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1215   -6.3165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7384    0.1927   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003040

>  <SMILES>
CN(C)S(=O)(=O)N1CCc2onc(COc3cccnc3)c2C1

$$$$
SWF003041
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   -0.8660    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003041

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccccc2)CC1

$$$$
SWF003042
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003042

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)C(=O)NC3c2ccccc2)cn1

$$$$
SWF003043
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003043

>  <SMILES>
CN(C)CC1CN(C(=O)c2cccc(O)c2)Cc2ccnn21

$$$$
SWF003044
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003044

>  <SMILES>
CN(C)CC1CCn2nccc2CN1C(=O)Cc1ccccc1F

$$$$
SWF003045
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.9081   -3.1645   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003045

>  <SMILES>
CS(=O)(=O)NCC1CCn2nccc2CN1C(=O)Cc1ccco1

$$$$
SWF003046
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  2  0  0  0  0
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M  END
>  <HTSID>
SWF003046

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2cccs2)CC1

$$$$
SWF003047
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
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    9.0933   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003047

>  <SMILES>
CCCS(=O)(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC)CC1

$$$$
SWF003048
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8106    0.7391   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    1.3625   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233    0.9972   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0762    3.9637   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 13  2  0  0  0  0
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 11 16  1  0  0  0  0
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 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  1  0  0  0  0
 17 23  1  0  0  0  0
 13 18  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003048

>  <SMILES>
Cc1cncc(C(=O)N2Cc3ccnn3CCC2CN(C)C)c1

$$$$
SWF003049
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
 27 30  2  0  0  0  0
 29 31  2  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 26 28  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003049

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)c4cnn5ccccc45)CC3)CC2=O)cc1

$$$$
SWF003050
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.4736    3.0934   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  7  1  0  0  0  0
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  7  9  1  0  0  0  0
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 10 12  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003050

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@@H]2CCN(C(=O)C3(F)CC3)C[C@H]2O1

$$$$
SWF003051
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 14 15  2  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003051

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCc2ncnc(-c3ccoc3)c2CC1

$$$$
SWF003052
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  9 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003052

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF003053
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003053

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)CC(N(C)C)CCO3)cs1

$$$$
SWF003054
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.2051   -7.5428   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.0904   -6.5391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4022   -5.0719   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6638   -7.0026   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2875   -4.0682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5491   -5.9989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8609   -4.5317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6414   -0.1055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0174   -1.9091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003054

>  <SMILES>
CN(C)C(=O)C1=NO[C@@H]2CN(C(=O)c3cccc(Cl)n3)C[C@H]12

$$$$
SWF003055
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0691    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    2.7971   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    5.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2544    5.9288   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8274    5.9288   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2909    7.3554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6726    8.5689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003055

>  <SMILES>
Cc1ccc(C(=O)N2CCc3nc(C(=O)N(C)C)sc3CC2)o1

$$$$
SWF003056
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    0.3231   -3.6646   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2185   -2.6701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0276   -2.0823   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6950   -2.2634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9411   -2.4890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7995   -1.2688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5040   -2.8511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7501   -1.9013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7131   -0.8621   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -2.4444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5221   -1.4499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4356   -1.0431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2447   -1.6309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  6  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003056

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@H]3OCC[C@@]3(C(=O)N3CCCC3)C2)cn1

$$$$
SWF003057
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9684   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2803   -0.1727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7512   -4.8565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4639   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2147   -6.2831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003057

>  <SMILES>
CN1C(=O)c2cccnc2C12CCN(C(=O)Cn1ccccc1=O)CC2

$$$$
SWF003058
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003058

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2ccccn2)CC1

$$$$
SWF003059
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.6295    2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6420    3.7898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3111    4.5329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7284    4.1965   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8111    5.3989   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8330    5.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003059

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)CN4CCCCC4)C3)CC2=O)cn1

$$$$
SWF003060
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.0428   -5.3431   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7859   -4.6739   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1768   -4.8431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -3.7604   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3847   -3.8649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -2.8944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792   -1.1623   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003060

>  <SMILES>
O=C(C1CC(O)C1)N1CCc2ncnc(-c3ccsc3)c2CC1

$$$$
SWF003061
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8090   -1.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9022    1.8025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2386    3.3852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
 10  8  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003061

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3OCC[C@@]3(C(=O)NCc3cccs3)C2)o1

$$$$
SWF003062
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    5.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8616    1.3138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7571    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8397    1.1059   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6706    2.7150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.3397    1.9719   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003062

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1CC12CCN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)C2

$$$$
SWF003063
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF003063

>  <SMILES>
Cc1ccoc1C(=O)N1CCn2cc(C(=O)N(C)C)nc2C1C

$$$$
SWF003064
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4389    5.1786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1509    2.2812   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4225    4.8650   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003064

>  <SMILES>
CC(=O)N1CCC2(COCc3cnc(-c4cccnc4)nc32)C1

$$$$
SWF003065
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -3.9684   -4.3601   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003065

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(C(=O)c2cccs2)CC1

$$$$
SWF003066
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF003066

>  <SMILES>
Cc1cccc(C(=O)N2CCn3cc(C(=O)N(C)C)nc3C2C)c1

$$$$
SWF003067
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003067

>  <SMILES>
CCN(C)C(=O)c1ncn2c1CCC(C(=O)N1CCOCC1)C2

$$$$
SWF003068
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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   -1.9797    6.3204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003068

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF003069
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.0933   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7781   -1.3240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3316    0.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4530    0.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.9739   -2.8112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003069

>  <SMILES>
COC1(CC(=O)N2CCc3c(CN(C)C)cncc3C2)CCC1

$$$$
SWF003070
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1715    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1715    4.2135   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2898    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  6  1  0  0  0  0
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  8 13  2  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003070

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1CN(C(=O)C2CC2)C[C@H]2OCC[C@H]21

$$$$
SWF003071
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5430    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1610    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8738    2.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1828    3.0741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1117    4.1445   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003071

>  <SMILES>
CC(C)NC(=O)C1CCc2c(C(=O)NCCCO)ncn2C1

$$$$
SWF003072
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.8745   -6.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3913   -6.7843   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4560   -5.6116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8433   -8.1806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0040   -4.2152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9728   -5.8351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7785   -9.3534   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3265   -7.9571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0688   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0375   -4.6624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8120   -9.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003072

>  <SMILES>
CC(C)N1CCOC2CN(C(=O)C3(C)CC=CCC3)CCC2C1

$$$$
SWF003073
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -3.1397   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -4.7577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6432   -3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6432   -4.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4522   -2.8609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003073

>  <SMILES>
Cc1ccc(C(=O)N2CC3OCCN(Cc4ccncc4)C3C2)o1

$$$$
SWF003074
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF003074

>  <SMILES>
COCC(=O)N[C@@H]1CN(C(=O)c2ccc(C)o2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF003075
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  6  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003075

>  <SMILES>
O=S(=O)(C1CC1)N1CCO[C@@H]2CCN(Cc3ccncc3)CC[C@H]21

$$$$
SWF003076
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
   10.3737   -2.0035   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF003076

>  <SMILES>
CC(C)CC(=O)N1CCC(C(=O)N(C)C)(n2cccn2)CC1

$$$$
SWF003077
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003077

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N(C)C)(n3ccnc3)CC2)cc1

$$$$
SWF003078
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
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 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003078

>  <SMILES>
CNC(=O)c1cc2c(n1C)CCCC2NC(=O)c1csc(C)n1

$$$$
SWF003079
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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    0.0863    2.4045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0687    3.8448   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5543    3.8448   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9588    5.0700   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  1  5  1  0  0  0  0
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 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
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 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003079

>  <SMILES>
Cn1ccc(NC(=O)C2(n3cccn3)CCN(S(C)(=O)=O)CC2)n1

$$$$
SWF003080
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -2.6183   -1.2273   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8886   -1.1367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6750   -2.6799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0024   -1.5906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7840   -3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8410   -1.0460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0547   -2.5893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8885   -2.4877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6231   -1.0460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8762   -2.6441   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3302   -1.7531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3288   -3.5875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3261   -3.6921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003080

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccn2)C1

$$$$
SWF003081
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -2.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003081

>  <SMILES>
O=C(NC1CC1)C1(Nc2nccs2)CCN(Cc2ccc(F)cc2)CC1

$$$$
SWF003082
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -3.9340   -6.0568   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -3.7855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2454   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9340   -1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7855   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003082

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(Cc2ccccc2F)CC1

$$$$
SWF003083
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003083

>  <SMILES>
CCC(=O)N1CCC(Nc2ccccc2)(C(=O)N(C)C)CC1

$$$$
SWF003084
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4348   -5.4085   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9932   -4.3611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7400   -5.9592   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  3  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003084

>  <SMILES>
CN(C)C1COC2(CCN(C(=O)C3(C#N)CCCC3)CC2)C1

$$$$
SWF003085
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003085

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(Cc2ccccc2)CC1

$$$$
SWF003086
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003086

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCN(Cc2ccccc2)CC1

$$$$
SWF003087
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003087

>  <SMILES>
CN(C)C(=O)C1(Nc2cccc(F)c2)CCN(Cc2cccnc2)CC1

$$$$
SWF003088
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -4.7127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5254   -4.2492   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5893   -5.2529   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0159   -4.7893   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2774   -6.7201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7409   -8.1467   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7263   -7.8348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003088

>  <SMILES>
COc1ccc(CN2C(=O)CCC23CCN(C(=O)C2CC2)CC3)cc1

$$$$
SWF003089
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7655    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7218    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0745    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527    2.8966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3617    3.8477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6926    4.5908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9005    5.5690   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6981    4.4863   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0345    6.0690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8140    5.9757   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2913    5.3999   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
 12 13  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF003089

>  <SMILES>
Cn1cncc1CN1CC[C@@H]2[C@@H](CO[C@H]2CC(=O)NCc2ccccc2)C1

$$$$
SWF003090
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   10.3610    1.8478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8476    5.8875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6908    7.3793   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4773    6.4976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1900   -1.6631   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003090

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CC1)CC(=O)N(CC1CC1)C2

$$$$
SWF003091
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3839    5.1680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749    5.7558   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4871    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 16 22  1  0  0  0  0
 17 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003091

>  <SMILES>
Cc1noc(C)c1CN1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF003092
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -7.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9089    0.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2988    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  1  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003092

>  <SMILES>
CC(C)NC(=O)C1CN(Cc2ccc(F)cc2)Cc2ncn(C)c21

$$$$
SWF003093
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.8148    8.7315   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.8185    7.6168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3550    6.1902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2858    7.9286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3587    5.0755   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8878    5.8783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2895    6.8139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8259    5.3873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4243    4.4517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9570    4.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4280    3.3370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4972    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003093

>  <SMILES>
CC(C)NC(=O)c1nnc2n1CC1(CC2)CCN(Cc2ccccc2F)CC1

$$$$
SWF003094
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.5989    1.2340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9298    1.9771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3421    1.9031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9603   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003094

>  <SMILES>
CS(=O)(=O)N1C[C@@H]2CCN(C(=O)/C=C/c3cccs3)[C@@H]2C1

$$$$
SWF003095
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.0360   -0.3752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7051   -1.1183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3669    0.3680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7792    0.2939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 18 21  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF003095

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2CN(C(=O)C3(C#N)CCCC3)C[C@@H]21

$$$$
SWF003096
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8057   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4783   -4.4155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003096

>  <SMILES>
O=C(c1cnccn1)N1CC2(C1)OCCC2COc1cccnc1

$$$$
SWF003097
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.5523   -4.5396   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2418   -3.7830   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8627   -3.7830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2418   -2.2698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9314   -4.5396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9314   -1.5132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
 22 26  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003097

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(S(=O)(=O)c2cccc(F)c2)CC1

$$$$
SWF003098
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 12 15  2  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003098

>  <SMILES>
O=C(N1CCCC2(CCN(c3cccnc3)C2=O)C1)C1(F)CC1

$$$$
SWF003099
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003099

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3ccc(C)cc3)C2)CN1CC1CC1

$$$$
SWF003100
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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    7.7942   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003100

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccc(C)cc2)CC1

$$$$
SWF003101
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8109    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2183    3.8172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0907    4.7683   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1965    3.6093   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  6  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003101

>  <SMILES>
CCNC(=O)c1ncn2c1CCC(C(=O)N1CCOCC1)C2

$$$$
SWF003102
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5893   -5.2529   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3921   -7.7238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003102

>  <SMILES>
O=C1CCC2(CCN(CC3CCCCC3)CC2)N1Cc1ccncc1

$$$$
SWF003103
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2341   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3401    2.9590   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  1  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  6  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003103

>  <SMILES>
Cc1noc([C@@]23CCO[C@@H]2CCN(S(=O)(=O)c2cn(C)cn2)C3)n1

$$$$
SWF003104
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9385   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1423   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0862   -7.9871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3080   -5.8774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2520   -7.0431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7437   -7.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003104

>  <SMILES>
COCCN1CC2(CCN(C(=O)C3CC(C)C3)CC2)CC1=O

$$$$
SWF003105
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6727   -0.3472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9875   -3.2661   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7418   -4.7458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003105

>  <SMILES>
CNC(=O)CC1CN(Cc2cccc(OC)c2)Cc2cccn2C1

$$$$
SWF003106
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF003106

>  <SMILES>
CCS(=O)(=O)CCN1Cc2cccn2CC(CC(=O)NC)C1

$$$$
SWF003107
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  2  0  0  0  0
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 15 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003107

>  <SMILES>
CNC(=O)CC1CN(Cc2cc(C)on2)Cc2cccn2C1

$$$$
SWF003108
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003108

>  <SMILES>
O=C(c1cnccn1)N1CC[C@@H]2CN(C(=O)C3(F)CC3)C[C@H]2C1

$$$$
SWF003109
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  6  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF003109

>  <SMILES>
CCN1CCC2(CN(C(C)=O)CC23CCN(C(=O)C2(F)CC2)CC3)C1=O

$$$$
SWF003110
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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  4  9  1  0  0  0  0
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  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003110

>  <SMILES>
CC(=O)N1CCC2(CC1)CC[C@@]1(C(=O)N(C)C)CN(C(C)=O)C[C@@H]21

$$$$
SWF003111
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003111

>  <SMILES>
O=C(N1CCCC1)N1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF003112
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.5921   -1.0477   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003112

>  <SMILES>
Cn1c(C(=O)N2CCn3c(-c4cccs4)cnc3C2)cccc1=O

$$$$
SWF003113
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003113

>  <SMILES>
CC(=O)NC1CCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF003114
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003114

>  <SMILES>
CS(=O)(=O)N1CC2(CN(C(=O)/C=C/c3cccs3)C2)c2nccnc21

$$$$
SWF003115
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003115

>  <SMILES>
O=C(NC1CC1)c1nnc2n1CC[C@@H]1CN(C(=O)/C=C/c3cccs3)C[C@@H]21

$$$$
SWF003116
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003116

>  <SMILES>
O=C(C1CCOC1)N1CCCC2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF003117
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003117

>  <SMILES>
CCn1cc(CN2CC3(C2)CN(CC2CC2)C(C(=O)NC)CO3)cn1

$$$$
SWF003118
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4407   -3.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003118

>  <SMILES>
O=C(c1ccccn1)N1CC2(CC(Oc3cccnc3)CS2)C1

$$$$
SWF003119
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003119

>  <SMILES>
O=C(c1cc[nH]n1)N1CC[C@@H]2OCCN(Cc3ccncc3)[C@H]2C1

$$$$
SWF003120
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6  9  1  0  0  0  0
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  7 11  1  6  0  0  0
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  9 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003120

>  <SMILES>
CCn1cc(CN2CC[C@H]3[C@@H]2CC(=O)N3C(C)c2ccccc2)cn1

$$$$
SWF003121
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   10.3610    1.8478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003121

>  <SMILES>
N#Cc1ccc(CC(=O)N2CCC3(CC2)CC(=O)N(CC2CC2)C3)cc1

$$$$
SWF003122
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003122

>  <SMILES>
Cc1ccccc1CN1CC2(CCC(CNS(C)(=O)=O)CO2)C1

$$$$
SWF003123
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  9  1  6  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7 10  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003123

>  <SMILES>
CN(C)Cc1noc2c1CC(NC(=O)c1ccccc1F)CC2

$$$$
SWF003124
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003124

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(CC(OCc3ccncc3)CCO2)C1

$$$$
SWF003125
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  3  0  0  0  0
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 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003125

>  <SMILES>
CCOC1CSC2(C1)CN(C(=O)c1cccc(C#N)c1)C2

$$$$
SWF003126
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003126

>  <SMILES>
CCCN(C)C(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF003127
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  2  0  0  0  0
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 21 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003127

>  <SMILES>
O=C(Nc1cccc(F)c1)c1nnc2n1C[C@@H]1CN(C(=O)C3CC3)C[C@@H]1C2

$$$$
SWF003128
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    4.1420    3.7902   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6259    3.7902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6259    2.2741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003128

>  <SMILES>
CC(=O)N1CCC(C(=O)NCC(F)(F)F)(n2cccn2)CC1

$$$$
SWF003129
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    7.5191   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003129

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)NCCOC)C2

$$$$
SWF003130
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003130

>  <SMILES>
CN1CCOC2CN(C(=O)c3ccnc(C(F)(F)F)c3)CCC2C1

$$$$
SWF003131
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF003131

>  <SMILES>
O=C(c1ncn2c1CCC(C(=O)N1CCCC1)C2)N1CC(F)C1

$$$$
SWF003132
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 27 28  1  0  0  0  0
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 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003132

>  <SMILES>
Cc1ccc(C(=O)N2CCc3ccc(=O)n(CC4CCOCC4)c3CC2)cn1

$$$$
SWF003133
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
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 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003133

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF003134
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  1  1  0  0  0
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M  END
>  <HTSID>
SWF003134

>  <SMILES>
O=C(NC1CCc2onc(CN3CC[C@@H](O)C3)c2C1)c1cnccn1

$$$$
SWF003135
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 17 18  1  6  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003135

>  <SMILES>
O=C(NC1CCCC1)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF003136
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 21 24  1  0  0  0  0
 12 15  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003136

>  <SMILES>
CCc1ccc(C(=O)N2CCc3ncnc(C4CC4)c3CC2)cn1

$$$$
SWF003137
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 14 15  1  6  0  0  0
 15 16  2  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003137

>  <SMILES>
CN(C)C(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF003138
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003138

>  <SMILES>
COCCNC(=O)C1(Nc2ccn(C)n2)CCN(CC2CCOCC2)CC1

$$$$
SWF003139
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6698    1.4115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6974    1.1780   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6575    1.2551   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5134    0.4238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  1  0  0  0
  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
  8 10  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003139

>  <SMILES>
Cn1cc(C[C@H]2[C@H](OCC3CC3)CCN2C(=O)CC2(O)CCC2)cn1

$$$$
SWF003140
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5881    1.3092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003140

>  <SMILES>
O=C(C1CC1)N1CCO[C@H]2[C@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF003141
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5490    4.7860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7905    4.1403   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    4.7860   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003141

>  <SMILES>
O=C(c1ccccc1)N1CCO[C@@H]2CN(CC3CCCC3)C[C@@H]2C1

$$$$
SWF003142
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.9282    4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003142

>  <SMILES>
CCC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC)CC1

$$$$
SWF003143
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003143

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C2CCC2)CC1

$$$$
SWF003144
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003144

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(Cc2ccc(F)cc2)CC1

$$$$
SWF003145
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    7.7942   -5.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
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 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003145

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)COC)CC1

$$$$
SWF003146
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 24 26  2  0  0  0  0
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF003146

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2ccccc2)CC1

$$$$
SWF003147
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 14 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003147

>  <SMILES>
CC(C)C(=O)NCCC1CN(Cc2ccccc2)Cc2ccnn21

$$$$
SWF003148
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003148

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2cccc(C)c2)CC1

$$$$
SWF003149
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5627    5.9213   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0795    5.6978   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2337    4.5798   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8338    4.2180   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0268    6.7663   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1651    3.5271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5078    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3887    2.0438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7850    1.4958   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1365   -0.8450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
  4  6  2  0  0  0  0
 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003149

>  <SMILES>
Cc1c(CN2Cc3ccnn3CCC2CN(C)C)cnn1C

$$$$
SWF003150
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    9.0091   -2.1647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6192   -0.7944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0864   -0.4826   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2432    1.0092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2011   -1.4863   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.8729    1.6193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8893   -2.9535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.0040   -3.9572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
M  END
>  <HTSID>
SWF003150

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)CN(C)C(C)C)C[C@H]2C)C1=O

$$$$
SWF003151
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
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  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003151

>  <SMILES>
COc1cccc(CN2CCC3(CC2)NC(=O)CC3c2ccncc2)c1

$$$$
SWF003152
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 17 18  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003152

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3cc(OC)no3)C[C@H]2C)C1=O

$$$$
SWF003153
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.4790    4.7749   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003153

>  <SMILES>
CN(C)c1ncc2c(n1)C1(CCN(c3ncc(F)cn3)C1)COC2

$$$$
SWF003154
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003154

>  <SMILES>
CN(C)Cc1cn2c(n1)CN(C(=O)Cc1cccc(F)c1)CC2

$$$$
SWF003155
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.2429   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.5738   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF003155

>  <SMILES>
CN(C)C(=O)NCCC1CN(Cc2ccsc2)Cc2ccnn21

$$$$
SWF003156
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.8362    4.5441   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.8112    4.3216   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1059    3.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003156

>  <SMILES>
COCCNC(=O)CC1CN(Cc2ccccc2F)Cc2cccn2C1

$$$$
SWF003157
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.7173    6.3037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2501    5.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4673    5.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4636    3.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF003157

>  <SMILES>
CN(C)C(=O)NCC1CN(Cc2ccsc2)Cc2ccnn21

$$$$
SWF003158
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003158

>  <SMILES>
O=C(C1CC(O)C1)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF003159
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0772   -1.8070   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4949   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8961   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3138   -4.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2685   -4.9385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2630   -4.8340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  8 10  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003159

>  <SMILES>
NC(=O)C1CCCN(C(=O)C2CC3(CO2)CN(Cc2ccncc2)CCO3)C1

$$$$
SWF003160
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.6941   -1.1030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9020   -0.1248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8531    0.1842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6621   -0.4036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1621    1.1353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4711    0.1842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1621    1.1353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 11  1  1  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003160

>  <SMILES>
O=C(Cc1ccccn1)N1C[C@@H]2C(C(=O)N3CCCC3)=NO[C@@H]2C1

$$$$
SWF003161
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9843    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2010    6.0850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2990    6.0850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003161

>  <SMILES>
O=C(c1cc[nH]c1)N1CCc2ncnc(-c3ccncc3)c2CC1

$$$$
SWF003162
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.8585    3.3792   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003162

>  <SMILES>
CCc1ccc(C(=O)N2CCC3OCCN(CCOC)C3CC2)cn1

$$$$
SWF003163
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    7.5303   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 19 20  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003163

>  <SMILES>
Cc1ncnc(C(=O)N2CCCC3(CC(C(=O)NCc4cccnc4)=NO3)C2)c1C

$$$$
SWF003164
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
    5.2406   10.3692   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    9.0702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9906    6.4721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003164

>  <SMILES>
Cc1cnc(CNC(=O)C[C@@H]2COC[C@H]3CN(C(=O)c4cccc(Cl)c4)C[C@@H]23)cn1

$$$$
SWF003165
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003165

>  <SMILES>
CC(=O)N1CCCC2(COCCN(c3cccc(C#N)c3)C2)C1

$$$$
SWF003166
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003166

>  <SMILES>
O=C(N1CC[C@@H]2OCCN(Cc3ccncc3)[C@H]2C1)C1(F)CC1

$$$$
SWF003167
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003167

>  <SMILES>
CCS(=O)(=O)N1CCC(Nc2ccn(C)n2)(C(=O)N2CCCC2)CC1

$$$$
SWF003168
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 23 26  1  0  0  0  0
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF003168

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cccc(C)c2)CC1

$$$$
SWF003169
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003169

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3C[C@@H](C(=O)NC4CC4)O[C@@H]3C2)cn1

$$$$
SWF003170
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
   -0.0000    3.7885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003170

>  <SMILES>
CS(=O)(=O)N1CCC(C(=O)NCC(F)(F)F)(n2cccn2)CC1

$$$$
SWF003171
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003171

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CCC(C(=O)NC1CCC1)C2

$$$$
SWF003172
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.1779   -4.6723   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003172

>  <SMILES>
CC(C)C(=O)NC1CCc2onc(C(=O)NCc3ccco3)c2C1

$$$$
SWF003173
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 14  9  1  1  0  0  0
 10 15  1  1  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003173

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@H]2OCC[C@H]2N(C(=O)C2CC2)C1

$$$$
SWF003174
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003174

>  <SMILES>
Cn1cnc(C(=O)N2C[C@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)n1

$$$$
SWF003175
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.4957   -4.3477   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5446   -4.6567   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2085   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 12  1  0  0  0  0
 13 14  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003175

>  <SMILES>
CC1c2ncc(CCOc3cccnc3)n2CCN1S(C)(=O)=O

$$$$
SWF003176
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.6531   -2.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3223   -1.2601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3004   -1.4680   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0132   -0.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9695   -0.7248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6010    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9477   -0.9328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0132    1.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003176

>  <SMILES>
CC(C)CC(=O)NC1CCc2onc(C(=O)NC(C)C)c2C1

$$$$
SWF003177
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3350    6.2282   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9616    7.2849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  2  0  0  0  0
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 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003177

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@@H](OCc2cccnc2)[C@H]2OCCC[C@@H]21

$$$$
SWF003178
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7210   -2.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6603    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  6  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
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 14 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 10 13  1  0  0  0  0
 17 19  2  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003178

>  <SMILES>
CCOCC1c2c(cnn2C)CCN1C(=O)COc1ccccc1

$$$$
SWF003179
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.5083   -1.7456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0411   -2.0575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0374   -0.9427   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5009    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1103   -3.7959   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5813   -4.5988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4972    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1177   -6.0253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003179

>  <SMILES>
CCOCC1CCC2C1OCCN2C(=O)c1ccc(C)nc1

$$$$
SWF003180
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7087    2.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2817    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8144    2.0698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8107    3.1845   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 14 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003180

>  <SMILES>
CC(C)CCNC(=O)c1ncn2c1CCC(C(=O)N1CCOCC1)C2

$$$$
SWF003181
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.0052    3.0878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003181

>  <SMILES>
CCC(=O)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF003182
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003182

>  <SMILES>
CCc1ccc(C(=O)N2CCCC3(CC2)CN(C)CCO3)cn1

$$$$
SWF003183
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003183

>  <SMILES>
CC(C)C(=O)NCCC1CN(Cc2cnn(C)c2)Cc2ccnn21

$$$$
SWF003184
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 14 15  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003184

>  <SMILES>
CO[C@@H]1CCN(C(=O)Cc2nc(C)no2)C[C@H]1Cc1ccccc1

$$$$
SWF003185
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003185

>  <SMILES>
CS(=O)(=O)NCCC1CN(Cc2ccccc2F)Cc2ccnn21

$$$$
SWF003186
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.2497   -0.7577   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2731    0.2479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003186

>  <SMILES>
CCC(=O)N1CCC(C(=O)NCCOC)(n2cccn2)CC1

$$$$
SWF003187
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003187

>  <SMILES>
CC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)N(C)C)CC1

$$$$
SWF003188
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    1.3527    5.5851   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
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 25 27  1  0  0  0  0
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 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003188

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2Cc3nnc(C(=O)NC4CCC4)n3C[C@@H]2C1

$$$$
SWF003189
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003189

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CCC2(CCCN(C(=O)c3cscn3)C2)CC1

$$$$
SWF003190
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2406    5.1731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 11 13  1  6  0  0  0
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 22 24  1  0  0  0  0
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  8  9  1  0  0  0  0
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M  END
>  <HTSID>
SWF003190

>  <SMILES>
O=C(C[C@@H]1COC[C@H]2CN(S(=O)(=O)C3CC3)C[C@@H]12)NCc1cccs1

$$$$
SWF003191
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003191

>  <SMILES>
CN1CCCCC1C1CCN(C(=O)c2ccnc(C(F)(F)F)c2)CC1

$$$$
SWF003192
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003192

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CCC(C2CCCCN2C)CC1

$$$$
SWF003193
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003193

>  <SMILES>
CCN1CC2(CCN(C(=O)c3cccc(Cl)n3)CC2)CC1=O

$$$$
SWF003194
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.2625    1.2909   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003194

>  <SMILES>
COCC1CCC2C1OCCN2C(=O)c1cccc(Cl)c1

$$$$
SWF003195
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003195

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cccnc2)CC1

$$$$
SWF003196
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  7  8  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003196

>  <SMILES>
CN1CCCCC1C1CCN(C(=O)CCc2ccccc2F)CC1

$$$$
SWF003197
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.7942    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003197

>  <SMILES>
CNC(=O)CN1CCC2(CCCN(C(=O)c3cc(C4CC4)on3)C2)CC1

$$$$
SWF003198
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.8970   -1.5409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 16 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003198

>  <SMILES>
CC(C)N1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF003199
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.3887    2.0438   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003199

>  <SMILES>
CS(=O)(=O)N1Cc2ccnn2CCC1COc1ncccc1F

$$$$
SWF003200
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003200

>  <SMILES>
CN1CCC2(CCCN(C(=O)/C=C/c3cccs3)C2)CC1

$$$$
SWF003201
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003201

>  <SMILES>
CC(C)NC(=O)c1nnc2n1C1(CC2)CCN(C(=O)/C=C/c2cccs2)C1

$$$$
SWF003202
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   17.4256    3.3107   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.1266    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.2294    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304    2.5607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5422    1.1118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003202

>  <SMILES>
CCS(=O)(=O)NCC1CCC2(CN(Cc3cccc(Cl)c3)C2)OC1

$$$$
SWF003203
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 19 17  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  6  0  0  0
 21 23  1  6  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003203

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C[C@H]32)cs1

$$$$
SWF003204
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  2  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003204

>  <SMILES>
Cc1ccccc1CN1CCC(Nc2cccc(F)c2)(C(=O)N(C)C)CC1

$$$$
SWF003205
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003205

>  <SMILES>
O=C(N1CCC2(CC(Nc3ncccn3)CO2)C1)C1(F)CCC1

$$$$
SWF003206
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 22 26  1  0  0  0  0
 24 27  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003206

>  <SMILES>
O=C(c1cccnc1)N1CCC(Nc2ccccc2)(C(=O)N2CCC2)CC1

$$$$
SWF003207
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.8669    1.2340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6100    1.9031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1456    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2283   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003207

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC[C@H]3CN(S(C)(=O)=O)C[C@H]32)n[nH]1

$$$$
SWF003208
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8974   -2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8249   -4.5988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5191   -4.9589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  1  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  6  9  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003208

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H](C)[C@@]3(CCN(c4cccnc4)C3=O)C2)cn1

$$$$
SWF003209
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003209

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(Cc2ccccc2)CC1

$$$$
SWF003210
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
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 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
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 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003210

>  <SMILES>
O=C(NCc1cccnc1)[C@@]12CCO[C@@H]1CCN(c1ncccn1)C2

$$$$
SWF003211
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8994   -4.7445   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8504   -4.4354   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003211

>  <SMILES>
CN(C)Cc1cnc2n1CCN(Cc1ccc(F)c(F)c1)CC2

$$$$
SWF003212
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3230   -3.5032   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5309   -4.4814   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3285   -3.3987   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6649   -4.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9217   -4.3122   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003212

>  <SMILES>
CC1c2ncc(Cn3cccn3)n2CCN1Cc1cccnc1

$$$$
SWF003213
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.2759   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -4.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003213

>  <SMILES>
CC1CC(C(=O)N2C[C@H]3CN(c4cncnc4)C(=O)[C@H]3C2)C1

$$$$
SWF003214
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.4250   -7.2450   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6329   -6.2669   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5840   -5.9578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8898   -5.5977   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7919   -4.9797   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3271   -6.6270   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0977   -4.6196   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7429   -4.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0487   -4.3106   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4861   -5.3398   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9509   -3.6925   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2077   -3.0234   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9019   -3.3835   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468    0.6499   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0686    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  1  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  1  0  0  0
 17 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003214

>  <SMILES>
COCCN1C[C@@]23CN(C(=O)c4cccc(Cl)c4C)C[C@@H](C[C@@H]2S1(=O)=O)O3

$$$$
SWF003215
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.7124    7.0843   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.9203    6.1062   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1772    5.4370   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8714    5.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3851    4.4589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0793    4.8190   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6420    3.7898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3362    4.1499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6909    4.0988   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4020    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  1  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003215

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3cccc(Cl)n3)C[C@H]2C)C1=O

$$$$
SWF003216
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4041    2.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8053    1.6691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3986    2.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7349    3.2213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7568    3.0134   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0136    3.6825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3500    2.0998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1476    3.1825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3555    2.2044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003216

>  <SMILES>
CC(C)CC(=O)NC1CCc2onc(CN3CCCC3)c2C1

$$$$
SWF003217
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.8022   -3.4223   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3900   -2.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3845   -2.7178   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9833   -1.6997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9723   -1.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5656   -0.9953   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1534   -0.1862   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003217

>  <SMILES>
CCOC1COC2(CCN(C(=O)c3cc(F)ncc3F)CC2)C1

$$$$
SWF003218
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6759    0.9432   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8040    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6994    1.4854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7821    0.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6130    1.8921   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2821    1.1489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003218

>  <SMILES>
C[C@@H]1CN(C(=O)c2csnn2)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF003219
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    9.2275   -2.6728   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -3.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -3.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -4.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -4.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7159   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  6  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  7  9  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003219

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CC[C@]2(C[C@@H](Oc3ncccc3F)CO2)C1

$$$$
SWF003220
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -4.7127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5254   -4.2492   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5893   -5.2529   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0159   -4.7893   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2774   -6.7201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7409   -8.1467   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7263   -7.8348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003220

>  <SMILES>
O=C(C1CC1)N1CCC2(CCC(=O)N2Cc2cccnc2)CC1

$$$$
SWF003221
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7321   -5.6369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -6.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2321   -8.2350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7321   -9.1010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -8.2350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -9.9670   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003221

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CCN(Cc3cccc(OC)c3)C[C@@H]2O1

$$$$
SWF003222
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.9339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8311   -1.9339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8555   -2.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6086   -2.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.6906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.6906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -4.5567   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -4.5567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2321   -5.4227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -5.4227   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2679   -4.5567   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7679   -5.4227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6340   -5.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7679   -6.4227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
 20 24  1  0  0  0  0
 21 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003222

>  <SMILES>
O=C(Cc1noc2ccccc12)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF003223
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2836    1.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003223

>  <SMILES>
C=CCN1CC2(CCN(Cc3cnn(CC)c3)CC2)OCC1=O

$$$$
SWF003224
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -2.6183   -1.2273   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7840   -3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8410   -1.0460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8885   -2.4877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6231   -1.0460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8762   -2.6441   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3261   -3.6921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003224

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccc2)C1

$$$$
SWF003225
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2557   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1024    1.3292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003225

>  <SMILES>
CN1Cc2nccn2CC12CCN(C(=O)/C=C/c1cccs1)C2

$$$$
SWF003226
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5317    2.4952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
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 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  2  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
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 20 26  2  0  0  0  0
 22 27  2  0  0  0  0
 25 28  2  0  0  0  0
 25 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
  5  8  1  0  0  0  0
 13 16  1  0  0  0  0
 21 26  1  0  0  0  0
 23 27  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003226

>  <SMILES>
CC(=O)c1cc(C(=O)N2CCOC3(C2)C(=O)N(Cc2cccnc2)CC3c2ccccc2)n[nH]1

$$$$
SWF003227
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4687   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2698   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8755   -6.7201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6139   -4.7893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003227

>  <SMILES>
CC(C)N1CCC2(CCC(=O)N2Cc2cccc(F)c2)CC1

$$$$
SWF003228
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4179    3.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
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 22 23  2  0  0  0  0
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 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 16 18  2  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003228

>  <SMILES>
COCCNC(=O)c1ccn(-c2ccc3ccc(-c4ccccc4)cn23)n1

$$$$
SWF003229
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7128   -3.2537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  1  1  0  0  0
 11 15  1  6  0  0  0
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 14 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003229

>  <SMILES>
O=S(=O)(c1ccc2c(c1)CCO2)N1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF003230
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  9  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003230

>  <SMILES>
CCOC1COC2(CCN(C(=O)Cc3ccc(OC)c(F)c3)CC2)C1

$$$$
SWF003231
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003231

>  <SMILES>
Cc1cc(C)nc(N2CC[C@H]3[C@@H]2CC(=O)N3Cc2csc(C)n2)n1

$$$$
SWF003232
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.0208   -0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5208    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0208    1.3660   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869   -0.4010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    1.4010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5208    2.2321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1120   -0.6235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 13 15  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003232

>  <SMILES>
CNC(=O)c1cc2c(nc1NCC1CC1)CCN(C(=O)NC)CC2

$$$$
SWF003233
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    1.7321    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 21 22  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003233

>  <SMILES>
CCN1CCc2cc(C(=O)N(C)C)c(NC(C)C)nc2CC1

$$$$
SWF003234
Actelion Java MolfileCreator 1.0

 32 36  0  0  1  0  0  0  0  0999 V2000
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 18 21  1  6  0  0  0
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 25 27  1  0  0  0  0
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 14 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF003234

>  <SMILES>
CC(=O)N1C[C@H]2C3(CCN(Cc4ccc(F)c(F)c4)CC3)CC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF003235
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003235

>  <SMILES>
COC1CC2(CCN(C(=O)c3cnc(Cl)cc3Cl)CC2)C1

$$$$
SWF003236
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  1  0  0  0
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 10 14  2  0  0  0  0
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 11 16  2  0  0  0  0
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 13 18  1  0  0  0  0
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 18 24  1  0  0  0  0
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 21 26  2  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF003236

>  <SMILES>
NC(=O)N1C[C@@H](c2ccccc2)[C@@]2(CCN(Cc3cccnc3)C2=O)C1

$$$$
SWF003237
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.9904   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003237

>  <SMILES>
C=CC(=O)N1CCC(Nc2ccccc2)(C(=O)NCCOC)CC1

$$$$
SWF003238
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003238

>  <SMILES>
CN(C)Cc1noc2c1CC(NS(=O)(=O)N(C)C)CC2

$$$$
SWF003239
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.8255    1.1637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4946    1.9068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1564    0.4205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0823    1.8328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
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  6 10  1  0  0  0  0
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  8 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF003239

>  <SMILES>
Cc1ccc(CN2CCCC3(CCCN3S(C)(=O)=O)C2)s1

$$$$
SWF003240
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.5797   -0.1402   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.2066   -0.7515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3638   -2.2463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9050   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8339   -2.5588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3017   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3017    1.5030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7515   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4432   -0.3139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6273   -2.5588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8490   -1.5696   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6330   -3.6758   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6919   -0.0748   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3192   -1.8821   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 19  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003240

>  <SMILES>
CC(=O)N1N=C(C)CC12CCC1CN(C(=O)/C=C/c3cccs3)CC12

$$$$
SWF003241
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9843    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9672   -1.0619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7537   -3.1638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    4.7860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    4.7860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5490    4.7860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5490    7.3840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2990    6.0850   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003241

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCc2ncnc(N3CCOCC3)c2CC1

$$$$
SWF003242
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4752   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8940   -3.8968   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4818   -3.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  6  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003242

>  <SMILES>
Cc1nnc([C@@]23CCO[C@@H]2CCN(C(=O)/C=C/c2cccs2)C3)o1

$$$$
SWF003243
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1756    0.9894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003243

>  <SMILES>
Cc1ccsc1CN1CC2(C1)OCCC2CCNS(C)(=O)=O

$$$$
SWF003244
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.2167   -6.6841   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003244

>  <SMILES>
O=C(c1ccncc1)N1CCc2[nH]nc(-c3ccc(F)cc3)c2CC1

$$$$
SWF003245
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.3147   -6.0326   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8147   -5.1665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  2  0  0  0  0
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 13 14  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003245

>  <SMILES>
Fc1cnc(N2CCO[C@H]3CN(Cc4ccoc4)C[C@H]32)nc1

$$$$
SWF003246
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF003246

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@@H]2OCCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF003247
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   10.0409   -2.0471   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003247

>  <SMILES>
Cc1cc(CN2C[C@H]3CCN(c4ncccc4F)CC[C@H]3C2)[nH]n1

$$$$
SWF003248
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  1  0  0  0
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 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 22 25  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003248

>  <SMILES>
O=S(=O)(c1ccc2c(c1)OCCO2)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF003249
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003249

>  <SMILES>
COc1ccc(CN2CC3(CCN(Cc4ccncc4)C3)C2)cc1

$$$$
SWF003250
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003250

>  <SMILES>
O=C(c1cncnc1)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF003251
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003251

>  <SMILES>
c1csc(CN2C[C@H](N3CCOCC3)[C@@H]3OCCC[C@@H]32)n1

$$$$
SWF003252
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003252

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1C[C@@H]2OCCN(c3ncccn3)[C@H]2C1

$$$$
SWF003253
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003253

>  <SMILES>
C=CCN1CCCC12CCN(C(=O)Cn1ccccc1=O)CC2

$$$$
SWF003254
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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   -3.0314   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 12 10  1  1  0  0  0
 13 11  1  1  0  0  0
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 13 15  1  0  0  0  0
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  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003254

>  <SMILES>
Cc1csc(C(=O)N2C[C@H]3CN(CC4CC4)C(=O)[C@H]3C2)c1

$$$$
SWF003255
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  1  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003255

>  <SMILES>
Cc1ccc(CN2CCO[C@H]3[C@H](OCc4ccncc4)CC[C@@H]32)o1

$$$$
SWF003256
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7216    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4746    1.7509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003256

>  <SMILES>
COCC(=O)N1CCOCC2(CCN(c3ccccn3)C2)C1

$$$$
SWF003257
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  2  0  0  0  0
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 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003257

>  <SMILES>
c1cc(CO[C@H]2CN(CC3CCC3)[C@@H]3CCCO[C@H]23)ccn1

$$$$
SWF003258
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 13  9  1  1  0  0  0
 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
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 18 23  1  0  0  0  0
 18 24  1  0  0  0  0
 21 25  2  0  0  0  0
 10 13  1  0  0  0  0
 19 20  1  0  0  0  0
 22 25  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003258

>  <SMILES>
O=C(NCCc1ccccn1)[C@H]1C[C@H]2OCC[C@H]2N(C(=O)C2CC2)C1

$$$$
SWF003259
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -3.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  2  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003259

>  <SMILES>
CN1C(=O)C2(CCN(Cc3cnn(C)c3)CC2)c2ccccc21

$$$$
SWF003260
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
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 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003260

>  <SMILES>
c1ccc(CN2C[C@H](OCc3cccnc3)[C@H]3OCCC[C@H]32)cc1

$$$$
SWF003261
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003261

>  <SMILES>
O=C(NC1CC1)C1=NOC2(CCN(C(=O)/C=C/c3cccs3)CC2)C1

$$$$
SWF003262
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003262

>  <SMILES>
Cn1ccc(N2CCC3(CCN(C(=O)c4ccnn4C)CC3)C2=O)n1

$$$$
SWF003263
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003263

>  <SMILES>
O=C(N1CCC2(CC1)CC(Nc1ncccn1)CCO2)C1(F)CCC1

$$$$
SWF003264
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003264

>  <SMILES>
CC(C)N1CCCC2(CC(C(=O)Nc3cccnc3)=NO2)C1

$$$$
SWF003265
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003265

>  <SMILES>
CCCN(C)C(=O)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF003266
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003266

>  <SMILES>
CN(C)C(=O)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF003267
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003267

>  <SMILES>
CC1c2nc(C(=O)N(C)C)cn2CCN1C(=O)c1cnccn1

$$$$
SWF003268
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003268

>  <SMILES>
COc1cccc(CN2CC3CN(c4ncccn4)CC3C2)c1

$$$$
SWF003269
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003269

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2ncccn2)CC1

$$$$
SWF003270
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003270

>  <SMILES>
CCNC(=O)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF003271
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003271

>  <SMILES>
O=C(N[C@H]1C[C@]2(CCN(C(=O)c3cc[nH]n3)C2)C1)c1ccncc1

$$$$
SWF003272
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003272

>  <SMILES>
O=C(N1CCC2(CC1)COCCN(Cc1ccncc1)C2)C1(F)CC1

$$$$
SWF003273
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    6.0622   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 17 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003273

>  <SMILES>
CC(C)CC(=O)N1CCCC(Nc2ccccc2)(C(=O)N(C)C)C1

$$$$
SWF003274
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003274

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)C2CCC2)CC1

$$$$
SWF003275
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 16 14  1  1  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003275

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CCN(C(=O)/C=C/c3cccs3)C[C@@H]2O1

$$$$
SWF003276
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1712   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003276

>  <SMILES>
CCOCC(=O)N1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF003277
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 16 19  2  0  0  0  0
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 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003277

>  <SMILES>
CC(=O)N1CCC2(CCC(=O)N2Cc2cccc(C)n2)CC1

$$$$
SWF003278
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.5340   -1.4390   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
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 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003278

>  <SMILES>
COc1cccc(CN2CC3(CCN(S(C)(=O)=O)C3)C2)c1

$$$$
SWF003279
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  2  0  0  0  0
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M  END
>  <HTSID>
SWF003279

>  <SMILES>
Cc1ccsc1C(=O)N1CCC(Nc2ccccc2)(C(=O)N(C)C)CC1

$$$$
SWF003280
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5807   -5.7695   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6405   -4.7713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003280

>  <SMILES>
COCc1ncn2c1CN(Cc1cccc(OC)c1)CCC2

$$$$
SWF003281
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003281

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF003282
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9352    1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9352   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4938   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003282

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(Cc2ccccc2)CC1

$$$$
SWF003283
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8454    0.8794   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003283

>  <SMILES>
Cc1ccc(C(=O)N2CCC[C@@]3(C[C@@H](OCC4CC4)CO3)C2)o1

$$$$
SWF003284
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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 15 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  9  1  6  0  0  0
 11 12  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003284

>  <SMILES>
CN(C)C(=O)CN1CC[C@H]2CN(Cc3ccccn3)C[C@@H]2C1=O

$$$$
SWF003285
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003285

>  <SMILES>
O=C(NC1CCc2onc(CN3CCOCC3)c2C1)C1CCOCC1

$$$$
SWF003286
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
   10.4636    0.8899   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4673    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7173    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003286

>  <SMILES>
CCC(=O)N1CCC(Nc2nccs2)(C(=O)NCCOC)CC1

$$$$
SWF003287
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    8.0145    2.4885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003287

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(Cc4sccc4C)C3)C2)cc1

$$$$
SWF003288
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003288

>  <SMILES>
O=c1cc(CN2CCCC2)nc2n1CCN(S(=O)(=O)C1CC1)C2

$$$$
SWF003289
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.8900    4.1521   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4887    3.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0711    2.4296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6643    1.5160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6698    1.4115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0514    1.9796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  1  0  0  0  0
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  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003289

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)Cc2ccccn2)C1

$$$$
SWF003290
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6209   -0.7566   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3105   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003290

>  <SMILES>
Cc1ccc(C(=O)N2CCC(C(=O)N3CCC3)(n3cccn3)CC2)o1

$$$$
SWF003291
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.1341    3.7830   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6209    3.7830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6209    2.2698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3105    1.5132   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003291

>  <SMILES>
Cn1cc(CN2CCC(C(=O)NCC(F)(F)F)(n3ccnc3)CC2)cn1

$$$$
SWF003292
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -6.5544   -4.5410   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2435   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9326   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3109   -6.0547   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003292

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2cccc(F)c2)CC1

$$$$
SWF003293
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003293

>  <SMILES>
CC(=O)N1CCC2(CCCN(C(=O)c3cscn3)C2)CC1

$$$$
SWF003294
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  1  0  0  0
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 10 14  1  0  0  0  0
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 18 21  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003294

>  <SMILES>
CN(Cc1ccccn1)C(=O)[C@H]1C[C@@H]2CCN(C(=O)C3CC3)C[C@H]2O1

$$$$
SWF003295
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11  7  1  1  0  0  0
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 14 10  1  1  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003295

>  <SMILES>
CC(=O)N1CC[C@H]2OC[C@@H](C(=O)Nc3cccnc3)C[C@H]2C1

$$$$
SWF003296
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003296

>  <SMILES>
Cc1cccc(C(=O)NC2CCc3onc(CN4CCOCC4)c3C2)c1

$$$$
SWF003297
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    5.4254    1.6075   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 18  2  0  0  0  0
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 18 22  1  0  0  0  0
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 21 26  2  0  0  0  0
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 28 29  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 23 28  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003297

>  <SMILES>
Cc1ccc(C(=O)N2CCC(F)(F)C3(CCN(Cc4c(C)noc4C)C3)C2)cn1

$$$$
SWF003298
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6066   -2.6351   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8238   -1.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6103   -3.7498   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9806   -3.1397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2796   -3.8897   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   15.0296   -5.1888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7796   -3.8897   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003298

>  <SMILES>
CCOC1COC2(CCN(C(=O)c3cc(C4CC4)on3)CC2)C1

$$$$
SWF003299
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    9.2456   -1.9375   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.2511   -1.8330   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8444   -0.9194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6633   -2.6420   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4431    0.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2621   -1.6239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0309    0.9076   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4486    0.2032   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8608   -0.6059   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0418    1.1167   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003299

>  <SMILES>
CNC(=O)C1CC2CN(C(=O)c3cccc(Cl)c3)CC1O2

$$$$
SWF003300
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.1667    4.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    5.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757    3.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    4.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
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 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
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 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5  6  1  0  0  0  0
 12 15  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003300

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCCN(C(=O)c2cccs2)C1

$$$$
SWF003301
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6275   -5.9087   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003301

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)c2cc[nH]n2)C3)n1

$$$$
SWF003302
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -5.7802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003302

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF003303
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6531   -2.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3223   -1.2601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.7017   -2.2770   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9096   -1.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0132    1.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003303

>  <SMILES>
COCC(=O)NC1CCc2onc(C(=O)N3CCCC3)c2C1

$$$$
SWF003304
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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   15.6894    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.0634    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.3903    3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.0913    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923    3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923    4.5583   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932    2.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1229    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3364    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6520    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003304

>  <SMILES>
CC(C)NC(=O)C[C@H]1C[C@H]2CN(C(=O)/C=C/c3cccs3)C[C@H]2O1

$$$$
SWF003305
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  1  0  0  0
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 15 18  2  0  0  0  0
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 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003305

>  <SMILES>
O=C(/C=C/c1cccs1)N1C[C@@H]2COC[C@]2(C(=O)NC2CC(F)(F)C2)C1

$$$$
SWF003306
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    8.5211    4.4017   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
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 10 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 24 26  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003306

>  <SMILES>
Cc1cc(C)cc(S(=O)(=O)N2CCn3cc(C(=O)N(C)C)nc3C2C)c1

$$$$
SWF003307
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003307

>  <SMILES>
O=C(/C=C/c1cccs1)N1C[C@@H]2C[C@H](CC(=O)N3CCOCC3)O[C@@H]2C1

$$$$
SWF003308
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4344   -2.9680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1472   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 10  2  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003308

>  <SMILES>
CCN(C)C(=O)c1ncn2c1CCC(C(=O)NCC1CC1)C2

$$$$
SWF003309
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.9100   -4.6723   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3356   -2.3544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6713   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003309

>  <SMILES>
CCOCC(=O)NC1CCc2onc(C(=O)NCc3ccco3)c2C1

$$$$
SWF003310
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003310

>  <SMILES>
O=C(c1cccc(Cl)n1)N1CCCC2(COCCN(c3ccccc3)C2)C1

$$$$
SWF003311
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    1.3818    3.7433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  6  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003311

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@]3(CCC[C@H](CN(C)C)O3)C2)cn1

$$$$
SWF003312
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003312

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(c4ncccn4)C3)C2)cc1

$$$$
SWF003313
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003313

>  <SMILES>
CC(C)N1CCc2nc(C(=O)NCc3ccccc3)sc2CC1

$$$$
SWF003314
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.3515    5.9146   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1947    7.4064   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9812    6.5247   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8432    6.0714   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2496    4.3875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230    3.3308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003314

>  <SMILES>
CC1CN(S(=O)(=O)N(C)C)CCC12CCC(C(=O)Nc1cccnc1)O2

$$$$
SWF003315
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003315

>  <SMILES>
O=C(NCCO)c1ncn2c1CCC(C(=O)NCC1CC1)C2

$$$$
SWF003316
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  1  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003316

>  <SMILES>
COCC(=O)NC1CCc2onc(CN3CC[C@@H](O)C3)c2C1

$$$$
SWF003317
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 22 26  1  0  0  0  0
 24 27  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003317

>  <SMILES>
O=C(c1ccncn1)N1CCC(Nc2ccccc2)(C(=O)N2CCC2)CC1

$$$$
SWF003318
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003318

>  <SMILES>
O=C(C1CC1)N1CCC2OCCN(Cc3ccncc3)C2CC1

$$$$
SWF003319
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4461   -2.1766   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0596   -0.7988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5348   -0.4852   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3055    0.5074   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6925    1.0148   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6556   -1.4944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5514    1.8135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2963   -0.6134   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3636    1.5644   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9534    2.0988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6649    3.0337   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9185   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6648    3.3490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2783    4.4115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6123   -0.7541   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7782    4.5692   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3062   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8916    6.1046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003319

>  <SMILES>
CC(C)CN1CC2(CCN(C(=O)C(C)(C)C)CC2)C2(CCN(C)C2=O)C1

$$$$
SWF003320
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4048   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.9801   -2.5998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1825   -3.6825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9746   -2.7044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003320

>  <SMILES>
O=C(NC1CCc2onc(CN3CCCC3)c2C1)c1ccc(F)cc1

$$$$
SWF003321
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5608   -1.0443   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7224   -4.1266   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4436   -5.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003321

>  <SMILES>
Cc1noc(C[C@@H]2C[C@H]3CN(Cc4ccc(F)c(F)c4)C[C@H]3O2)n1

$$$$
SWF003322
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4752   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4048   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1260   -5.4814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6649   -4.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7138   -6.2904   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6649   -5.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003322

>  <SMILES>
Cc1ccc(C(=O)NC2CCc3onc(CN4CCCC4)c3C2)cc1

$$$$
SWF003323
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0435    1.7809   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    3.7855   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5567    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5567    4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    0.7571   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2454    2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5567    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0263   -0.7488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6227   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3113   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 14 19  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003323

>  <SMILES>
CCC(=O)N1CCC(C(=O)Nc2ccn(C)n2)(n2ccnc2)CC1

$$$$
SWF003324
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    4.2992    1.3332   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
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 13 17  1  0  0  0  0
 20 23  1  0  0  0  0
 26 27  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003324

>  <SMILES>
CC[C@@H]1N(C(=O)c2cc(C3CC3)on2)CCC[C@]12CCC(=O)N2Cc1ccncc1

$$$$
SWF003325
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003325

>  <SMILES>
Cc1cccc(C(=O)NC2CCc3onc(CN4CCCC4)c3C2)c1

$$$$
SWF003326
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    7.9262   -3.4553   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2571   -2.7121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4262   -4.3213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3435   -3.1189   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4650   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
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 13 15  1  6  0  0  0
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 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF003326

>  <SMILES>
CN(C)C(=O)NC[C@@H]1CO[C@@H]2CN(Cc3nccs3)C[C@H]12

$$$$
SWF003327
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    5.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003327

>  <SMILES>
COCC12CCCOC1CCN(Cc1ccc(F)c(F)c1)C2

$$$$
SWF003328
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 21 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF003328

>  <SMILES>
O=C(Cn1ccnn1)N1CCc2ncnc(-c3ccncc3)c2CC1

$$$$
SWF003329
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003329

>  <SMILES>
CCc1ccc(CN2CCc3oc(C(=O)NC(C)C)nc3C2)cc1

$$$$
SWF003330
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003330

>  <SMILES>
COc1ccc(CN2C(=O)CCC23CCN(CCc2ccccc2)CC3)cc1

$$$$
SWF003331
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 15 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 10 11  2  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003331

>  <SMILES>
Cn1cnc2c1CC(COCc1ccccn1)N(S(C)(=O)=O)C2

$$$$
SWF003332
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    7.5191   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003332

>  <SMILES>
COCCNC(=O)C1CCc2c(C(=O)NC(C)C)ncn2C1

$$$$
SWF003333
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 11 15  2  0  0  0  0
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 21 23  2  0  0  0  0
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 22 25  1  0  0  0  0
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 14 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003333

>  <SMILES>
Cc1cccc(CN2CCC(C(=O)N3CCC3)(n3cccn3)CC2)c1

$$$$
SWF003334
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0250    0.5460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7570    0.5460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9160    0.0920   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 20 23  3  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003334

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)C4(C#N)CCCC4)C3)CC2=O)cn1

$$$$
SWF003335
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8374    2.9050   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2708    3.3472   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  3  0  0  0  0
  7  8  1  0  0  0  0
 10 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003335

>  <SMILES>
N#Cc1cccc(N2CCOCC3(CCCN(C(=O)C4CC4)C3)C2)c1

$$$$
SWF003336
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003336

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(C(=O)c1csnn1)C2

$$$$
SWF003337
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003337

>  <SMILES>
CC1CC(C(=O)N2C[C@H]3CN(CCN4CCCC4)C(=O)[C@H]3C2)C1

$$$$
SWF003338
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  1  5  1  0  0  0  0
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  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 17  1  1  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003338

>  <SMILES>
O=C1NCC(c2ccccc2)C12CCN(S(=O)(=O)C1CC1)CC2

$$$$
SWF003339
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003339

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(C(=O)C2CCC2)C1

$$$$
SWF003340
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -3.7818   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003340

>  <SMILES>
Cn1ccc(NC(=O)C2(n3ccnc3)CCN(Cc3nccs3)CC2)n1

$$$$
SWF003341
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -2.6183   -1.2273   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7840   -3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8410   -1.0460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8885   -2.4877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003341

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cn[nH]c2)C1

$$$$
SWF003342
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -2.6183   -1.2273   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7273   -1.6813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003342

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cccnc2)C1

$$$$
SWF003343
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.6603   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  2  0  0  0  0
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF003343

>  <SMILES>
C=CCN1CC2(CCN(Cc3cccc(F)c3)CC2)OCC1=O

$$$$
SWF003344
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.3004   -1.4680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003344

>  <SMILES>
COCC(=O)NC1CCc2onc(C(=O)NCC3CC3)c2C1

$$$$
SWF003345
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14  9  1  1  0  0  0
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 10 14  1  0  0  0  0
 17 22  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003345

>  <SMILES>
O=C(NCc1cccnc1)[C@H]1C[C@H]2OCC[C@H]2N(C(=O)C2CC2)C1

$$$$
SWF003346
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003346

>  <SMILES>
Cc1cc(C(=O)N2CC(F)(F)CC3(CCNC3=O)C2)cc(C)n1

$$$$
SWF003347
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003347

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF003348
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.4862   -0.2727   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  6  0  0  0
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 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003348

>  <SMILES>
O=C(N1CCO[C@H]2[C@@H](Oc3ccccn3)CC[C@@H]21)C1(F)CC1

$$$$
SWF003349
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 26 27  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 22 26  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003349

>  <SMILES>
Cc1ccc(N2CCC3(CN(C(=O)c4ccnn4C)CCC3(F)F)C2)nn1

$$$$
SWF003350
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003350

>  <SMILES>
CNC(=O)CC1CN(S(=O)(=O)c2ccccc2)Cc2ccnn21

$$$$
SWF003351
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003351

>  <SMILES>
c1ccc(CN2CCn3cc(CN4CCOCC4)nc3C2)cc1

$$$$
SWF003352
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003352

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@]3(C2)C[C@H](NC(=O)N(C)C)C3)cn1

$$$$
SWF003353
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003353

>  <SMILES>
COc1cc(C(=O)N2CC[C@]3(C2)C[C@H](NC(=O)N(C)C)C3)on1

$$$$
SWF003354
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
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 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 11 15  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003354

>  <SMILES>
Cn1cnc(S(=O)(=O)N2CCCC3(CCN(Cc4ccncc4)C3=O)C2)c1

$$$$
SWF003355
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003355

>  <SMILES>
O=C(N1CCCC2(COCCN(c3ncccn3)C2)C1)C1(F)CC1

$$$$
SWF003356
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.1083    3.9290   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7893    5.2655   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9040    4.2618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3258    6.6920   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3221    5.5773   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3306    4.7253   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5921    2.7945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1655    2.3310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7068    1.7909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3950    0.3236   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003356

>  <SMILES>
O=C1CCC2(CCN(C(=O)C3(F)CC3)CC2)N1Cc1cccnc1

$$$$
SWF003357
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5549   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003357

>  <SMILES>
Cc1cccc(CN2CCC3(CC2)CC(NC(=O)N(C)C)C3)n1

$$$$
SWF003358
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7426    1.7509   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6010    2.2638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7427    6.2327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003358

>  <SMILES>
O=C(c1cc[nH]n1)N1CCOCC2(CC(Cn3ccnc3)CO2)C1

$$$$
SWF003359
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0372   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6230   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -5.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -5.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  8 11  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003359

>  <SMILES>
CN1CCC(COCC2CC2)CC12CN(C(=O)c1ccncc1)C2

$$$$
SWF003360
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13  9  1  1  0  0  0
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 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
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 13 18  1  0  0  0  0
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 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 16 17  2  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003360

>  <SMILES>
O=C(NCc1ccco1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2cn[nH]c2)C1

$$$$
SWF003361
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   10.3863    4.1658   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.9228    2.7393   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9265    1.6245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9920    1.0008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4630    0.1980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9957   -0.1139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 10 12  1  0  0  0  0
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 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF003361

>  <SMILES>
Fc1ccccc1CN1CCO[C@H]2[C@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF003362
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003362

>  <SMILES>
O=C(C1CC(O)C1)N1CCC2(CCC(=O)N2Cc2cccnc2)CC1

$$$$
SWF003363
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 25 27  2  0  0  0  0
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 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF003363

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCOC2(COCCN(Cc3ccncc3)C2)C1

$$$$
SWF003364
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  6  9  1  0  0  0  0
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 10 14  1  0  0  0  0
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 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF003364

>  <SMILES>
Cc1ccc(CN2C(=O)C[C@H]3[C@@H]2CCN3Cc2ccncc2)cc1

$$$$
SWF003365
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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 10 14  1  6  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF003365

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(S(=O)(=O)c1cn(C)cn1)C2

$$$$
SWF003366
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.4080   -1.6631   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 26 27  1  0  0  0  0
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 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003366

>  <SMILES>
CC(=O)N1CC(=O)N(c2cnn(C)c2)CC12CCN(C(=O)C1(F)CCC1)C2

$$$$
SWF003367
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  1  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003367

>  <SMILES>
COCC1CCN(C)C2(C1)CN(C(=O)c1ccc(C)c(C)c1)C2

$$$$
SWF003368
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14  9  1  1  0  0  0
 10 15  1  1  0  0  0
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 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 10 14  1  0  0  0  0
 17 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003368

>  <SMILES>
CC(=O)N1C[C@@H](C(=O)NCc2cccnc2)C[C@H]2OCC[C@H]21

$$$$
SWF003369
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF003369

>  <SMILES>
Cc1ccc(C(=O)N2CC3OCCN(Cc4c(C)noc4C)C3C2)o1

$$$$
SWF003370
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 14  1  0  0  0  0
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 16 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003370

>  <SMILES>
CN1CCC2(CCCN(C(=O)c3ccnc(C(F)(F)F)c3)C2)CC1

$$$$
SWF003371
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 11 10  1  6  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003371

>  <SMILES>
CN(C)Cc1noc2c1CC(NC(=O)c1ccc(F)cc1)CC2

$$$$
SWF003372
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.4490   -2.9888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1292   -3.7219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003372

>  <SMILES>
CCN1CCO[C@@H]2CN(Cc3cccc(OC)c3)CC[C@@H]2C1

$$$$
SWF003373
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.7452    0.6623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4243   -0.5633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9366    2.4104   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 16 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003373

>  <SMILES>
C=CCN1CCOCC2(C1)CN(Cc1cccc(OC)c1)CCO2

$$$$
SWF003374
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003374

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)c3ncn(C)n3)CC2)O1

$$$$
SWF003375
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003375

>  <SMILES>
CN(Cc1ccccn1)C(=O)[C@H]1C[C@@H]2CCN(S(=O)(=O)C3CC3)C[C@H]2O1

$$$$
SWF003376
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003376

>  <SMILES>
O=C(c1cccc(Cl)n1)N1CC[C@]2(C[C@@H](Oc3ncccc3F)CO2)C1

$$$$
SWF003377
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
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 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003377

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)Cn1ccccc1=O)C2

$$$$
SWF003378
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003378

>  <SMILES>
Cn1cccc1C(=O)N1C[C@H]2CN(Cc3cccc(F)c3)C[C@H]2C1

$$$$
SWF003379
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003379

>  <SMILES>
Cc1ncnc(C(=O)N2CCCC3(CCN(c4ccsc4)C3=O)C2)c1C

$$$$
SWF003380
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003380

>  <SMILES>
O=C(Cc1ccc(F)cc1)N1CC2(C1)OCCC2COc1ccccn1

$$$$
SWF003381
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
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 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003381

>  <SMILES>
COc1cc(C(=O)N2CCC3(CCCn4c(C(=O)NCC5CC5)nnc43)CC2)on1

$$$$
SWF003382
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003382

>  <SMILES>
O=C(N1CCCC1)N1CCC2(CC1)CC(N1CCCC1)CO2

$$$$
SWF003383
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 17 18  1  6  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003383

>  <SMILES>
CCC(CC)NC(=O)c1ncn2c1CCC(C(=O)NC(C)C)C2

$$$$
SWF003384
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8 10  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  CHG  2   2   1   3  -1
M  END
>  <HTSID>
SWF003384

>  <SMILES>
CN1CCC2(CCN(C(=O)c3cccc([N+](=O)[O-])c3)CC2)C1

$$$$
SWF003385
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003385

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)c3ccnn3C)C2)C1

$$$$
SWF003386
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 10 16  1  0  0  0  0
 11 13  2  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003386

>  <SMILES>
CCn1nccc1C(=O)N1CCCC2(CCCN(c3nccc(C)n3)C2)C1

$$$$
SWF003387
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 16  2  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003387

>  <SMILES>
O=C(c1cnccn1)N1CCOC2(CCCN(c3ccccc3)C2)C1

$$$$
SWF003388
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 21 19  1  1  0  0  0
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 22 24  1  6  0  0  0
 23 25  1  6  0  0  0
 24 26  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003388

>  <SMILES>
O=C(c1ccsc1)N1CCO[C@@H]2CN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CC[C@@H]2C1

$$$$
SWF003389
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
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  9 12  1  6  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 15 16  2  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003389

>  <SMILES>
CN(C)C(=O)N1C[C@@H](C(=O)NCc2ccco2)C[C@H]2OCC[C@H]21

$$$$
SWF003390
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003390

>  <SMILES>
CCS(=O)(=O)NCC1CN(Cc2cccs2)Cc2cncn21

$$$$
SWF003391
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 23 25  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003391

>  <SMILES>
CC1c2nc(C(=O)N3CCCC3)cn2CCN1Cc1ccc2c(c1)OCO2

$$$$
SWF003392
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003392

>  <SMILES>
COc1ncccc1CN1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF003393
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.4128    4.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    3.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 17 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003393

>  <SMILES>
O=C(N[C@@H]1CN(Cc2ccsc2)C[C@@H]2CCCO[C@@H]21)c1ccno1

$$$$
SWF003394
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.2582    3.5103   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0014    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    1.8630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003394

>  <SMILES>
CN(C)CCN1CCCC12CCN(C(=O)c1ccco1)CC2

$$$$
SWF003395
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF003395

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(N(C)C)CCO2

$$$$
SWF003396
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003396

>  <SMILES>
CN(C)Cc1cnc2n1CCN(C(=O)Cc1ccc(F)cn1)CC2

$$$$
SWF003397
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003397

>  <SMILES>
Cc1ccc(N2CCCC3(CN(C(=O)C4(F)CC4)CCO3)C2)nn1

$$$$
SWF003398
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3950    2.8653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6897    3.8209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4490    3.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1264    4.6472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1292    4.7219   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7639    5.6528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7750    5.8018   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 12  1  0  0  0  0
 17 18  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003398

>  <SMILES>
CCN1CCOC2CN(C(=O)CCc3ccc[nH]3)CCC2C1

$$$$
SWF003399
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.5077    3.1532   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4273    3.5462   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2274    2.9464   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5467    4.5391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0342    1.9653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1150    3.4071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4201    5.0261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8136    5.2193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0285    3.0003   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2268    6.0072   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2340    6.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6803    1.2323   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2801    2.0325   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003399

>  <SMILES>
CN(C)CC1CCC2(COCCN(C(=O)c3ccoc3)C2)O1

$$$$
SWF003400
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    7.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    9.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   11.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   12.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    9.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   13.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   11.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   14.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003400

>  <SMILES>
COc1cccc(CN2CCC3(CCC(C(=O)NC(C)C)OC3)CC2)c1

$$$$
SWF003401
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6859    3.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003401

>  <SMILES>
Cn1cc(-c2ncnc3c2CN(C(=O)/C=C/c2cccs2)CC3)cn1

$$$$
SWF003402
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8087    3.8761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9997    4.4638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1907    3.8761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003402

>  <SMILES>
c1ccc(CO[C@H]2CN(CC3CCCC3)[C@@H]3CCCO[C@H]23)nc1

$$$$
SWF003403
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8206   -1.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1078   -2.5168   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4387   -3.2599   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0349   -5.3699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6747   -7.0641   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6529   -7.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 14 15  1  0  0  0  0
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 16 17  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
  9 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003403

>  <SMILES>
COc1ccc(CNC2CCc3onc(CN(C)C)c3C2)cc1

$$$$
SWF003404
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    5.1962   -8.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 19 21  1  0  0  0  0
 22 23  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003404

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)OC(C(=O)N2CCOCC2)Cn2ccnc23)o1

$$$$
SWF003405
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.7406    5.1731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2406    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3805    2.5037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4824    3.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2896    7.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9906    7.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003405

>  <SMILES>
Cc1cnc(CNC(=O)C[C@@H]2COC[C@H]3CN(C(=O)C4CC4)C[C@@H]23)cn1

$$$$
SWF003406
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    7.0327    5.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0109    5.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003406

>  <SMILES>
COCC(=O)N[C@@H]1CN(C(=O)/C=C/c2cccs2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF003407
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003407

>  <SMILES>
Cc1ccccc1S(=O)(=O)NC1CCc2onc(CN3CC[C@@H](O)C3)c2C1

$$$$
SWF003408
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    1.2848   -3.2716   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8724   -6.3772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5413   -6.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2295   -7.5907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 15 18  2  0  0  0  0
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 16 20  1  6  0  0  0
 17 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003408

>  <SMILES>
O=C(/C=C/c1cccs1)N1CC[C@H]2OCC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF003409
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -3.1668   -8.6442   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8551   -7.8869   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -6.8159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -6.0586   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -6.8159   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -4.5439   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -3.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3117    1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003409

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCCN(C(=O)C2CC(F)C2)C1

$$$$
SWF003410
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -2.2705   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003410

>  <SMILES>
Cc1cnc(C(=O)N2CCC(C(=O)N(C)C)(n3cccn3)CC2)cn1

$$$$
SWF003411
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
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  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003411

>  <SMILES>
O=C1CC(c2ccccc2)C2(CCN(C(=O)Cc3ccccn3)CC2)N1

$$$$
SWF003412
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003412

>  <SMILES>
C=CCN1CCN(C)C2(CCN(Cc3ccccn3)CC2)C1=O

$$$$
SWF003413
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9277    2.4499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003413

>  <SMILES>
COCC1CCC2(CCN(Cc3cccnc3)CC2)N1S(C)(=O)=O

$$$$
SWF003414
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8185   -5.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1494   -5.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6494   -6.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8451   -5.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003414

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)CC(N(C)C)CCO3)o1

$$$$
SWF003415
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    8.0015   -5.6119   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9978   -6.7266   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0892   -3.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3221   -6.4828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8161   -6.3484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1683   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4466   -4.9873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003415

>  <SMILES>
COCCN(C)C(=O)c1ncn2c1CN(C)S(=O)(=O)c1ccccc1-2

$$$$
SWF003416
Actelion Java MolfileCreator 1.0

 32 35  0  0  1  0  0  0  0  0999 V2000
    7.8108   -0.2885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1417    0.4546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  6  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 22 27  1  0  0  0  0
 24 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 28 31  2  0  0  0  0
 28 32  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003416

>  <SMILES>
COc1ccc(NC(=O)N2CCC3(CC2)CC[C@@]2(C(=O)N(C)C)CN(C(C)=O)C[C@@H]32)cc1

$$$$
SWF003417
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6337   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003417

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1C[C@H](Oc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF003418
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
   11.3399   -4.2971   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.5899   -5.5961   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8841   -2.0553   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.9380   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -2.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4169   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 18 22  1  0  0  0  0
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 26 27  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 17  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003418

>  <SMILES>
CN(C)C(=O)CN1CC[C@@H]2CN(S(=O)(=O)c3ccc4ncsc4c3)C[C@@H]2CC1

$$$$
SWF003419
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   12.7888   -4.9515   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.3253   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5753   -5.8331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8253   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3618   -4.9515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4518   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003419

>  <SMILES>
CC(=O)N1CC(=O)N(c2ccsc2)CC12CCN(C(=O)CCF)C2

$$$$
SWF003420
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003420

>  <SMILES>
O=C(N1CCOC2(CCCN(c3ncccn3)C2)C1)C1(F)CCC1

$$$$
SWF003421
Actelion Java MolfileCreator 1.0

 19 21  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003421

>  <SMILES>
O=C1NC[C@@H]2CN(C(=O)c3cnc(Cl)cc3Cl)C[C@H]12

$$$$
SWF003422
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  2  0  0  0  0
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  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003422

>  <SMILES>
CC1CCC(C(=O)N2CCC3(CC2)CC(C(=O)NC2CC2)=NO3)CC1

$$$$
SWF003423
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003423

>  <SMILES>
CC(=O)c1cc(C(=O)N2CCC3(CC2)CC(=O)N(Cc2csc(C)n2)C3)n[nH]1

$$$$
SWF003424
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    4.3301   -5.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667   -5.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757   -4.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449   -6.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449   -5.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 12  8  1  1  0  0  0
 13 11  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003424

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H]2OC[C@@H](C(=O)N3CCCC3)C[C@H]2C1

$$$$
SWF003425
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003425

>  <SMILES>
O=C1NC(c2ccccc2)C12CCN(CC1CCCCC1)CC2

$$$$
SWF003426
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.6280    0.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4941    0.6374   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3601    3.1374   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4941    4.6374   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6280    5.1374   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003426

>  <SMILES>
CCc1ccc(C(=O)N2CC3CCC(C2)N3CCOC)cn1

$$$$
SWF003427
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.0217   -5.0831   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1919   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7717   -2.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6618   -4.6649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7283   -2.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6533   -1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7765   -3.6612   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -3.7397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  7  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003427

>  <SMILES>
Cc1ccsc1CN1CC2(C1)OCCC2COCc1ccncc1

$$$$
SWF003428
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   11.2248   -1.9363   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.5951   -1.3261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2211   -0.8215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4383    0.1656   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.8941   -2.0761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9711    0.4775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
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 26 28  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003428

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)Cn4ccccc4=O)CC3)CC2=O)cs1

$$$$
SWF003429
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8908   -3.5134   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1779   -4.6723   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5326   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1779   -6.2904   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1290   -5.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003429

>  <SMILES>
CC(C)C(=O)NC1CCc2onc(C(=O)N3CCCC3)c2C1

$$$$
SWF003430
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    4.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  1  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003430

>  <SMILES>
C[C@H]1CC[C@H](C(=O)N2CCC3(CCN(c4ncccn4)C3)CC2)CC1

$$$$
SWF003431
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003431

>  <SMILES>
CC(=O)N1CCC2(CC1)CN(Cc1ccccn1)C(=O)CO2

$$$$
SWF003432
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.3229   -4.2409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4858   -5.3016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9347   -5.6898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6847   -6.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  1  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003432

>  <SMILES>
CC1CC(C(=O)N2CC[C@H]3C[C@H](C(=O)N4CCCC4)O[C@@H]3C2)C1

$$$$
SWF003433
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2513   -1.8799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6332   -3.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2805   -4.3172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003433

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)NC1CCC1)C2

$$$$
SWF003434
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.6778   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2710   -1.2522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7710   -0.3862   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1019    0.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1883   -0.0498   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3098    1.3351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2609    1.6441   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
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 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003434

>  <SMILES>
CC(C)(C)C(=O)N1C[C@H]2CC[C@@]3(N=C(c4ccccc4)NC3=O)[C@H]2C1

$$$$
SWF003435
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2302    1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
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 11 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 13  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003435

>  <SMILES>
O=C(NC1CCC1)[C@@H]1CN(C(=O)CCc2cncnc2)C[C@H]2OCC[C@H]21

$$$$
SWF003436
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
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  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003436

>  <SMILES>
Cn1cc(CN2CC[C@H]3O[C@@H](COCC4CC4)CC[C@H]32)cn1

$$$$
SWF003437
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.7195   -1.3849   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7414   -1.5928   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003437

>  <SMILES>
COCC1CCC2(CCN(C(=O)C3(F)CC3)CC2)N1S(C)(=O)=O

$$$$
SWF003438
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
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 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  8  1  0  0  0  0
 11 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003438

>  <SMILES>
O=C(N1C[C@H](Oc2cccnc2)[C@H]2OCCC[C@H]21)C1(F)CCC1

$$$$
SWF003439
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.5851    1.3053   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0486   -0.1212   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0523    0.9935   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1179    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3716    3.4072   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3679    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7850    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 19 21  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003439

>  <SMILES>
O=C(Nc1ccccc1)N1CC[C@@H]2CNS(=O)(=O)[C@@H]2CC1

$$$$
SWF003440
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6561    3.9127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5120    3.0814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003440

>  <SMILES>
c1cc(CO[C@@H]2CN(CC3CCC3)[C@@H]3CCCO[C@@H]32)ccn1

$$$$
SWF003441
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.1132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.2252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.2252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.3434   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.2748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.2748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 13  1  0  0  0  0
 10 12  1  0  0  0  0
 11 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003441

>  <SMILES>
O=C(C1CC(O)C1)N1C2CCC1CN(Cc1cccnc1)C2

$$$$
SWF003442
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462    0.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6727   -0.3472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9875   -3.2661   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4707   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7418   -4.7458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2508    2.1858   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1554    0.4186   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1417   -4.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0731   -5.4368   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1756    1.5182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5975   -1.0147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6380    1.1844   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0599   -1.3485   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.5020   -2.7819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003442

>  <SMILES>
Cc1cncc(C(=O)N2Cc3cccn3CC(CCNS(C)(=O)=O)C2)c1

$$$$
SWF003443
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7518   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3974   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 13 10  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003443

>  <SMILES>
Cc1nc(CN2C[C@@H]3CN(C(=O)C(C)(C)C)C[C@@H]3C2=O)cs1

$$$$
SWF003444
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3119    0.7172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1147   -1.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9872   -2.9672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4138   -0.4963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8037    0.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 12  1  0  0  0  0
  7 13  1  6  0  0  0
  8 14  1  0  0  0  0
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 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003444

>  <SMILES>
CC(=O)N1CCC2(CC1)CC[C@@]1(C(=O)N3CCCC3)CN(C)C[C@@H]21

$$$$
SWF003445
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003445

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CO[C@@H]2CN(Cc3ccoc3)C[C@H]12

$$$$
SWF003446
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 16 19  1  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
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 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003446

>  <SMILES>
O=C(C1CC1)N1CCC(F)(F)C2(CCN(c3ncccn3)C2)C1

$$$$
SWF003447
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF003447

>  <SMILES>
Cc1ccc(S(=O)(=O)NC2CCc3onc(CN(C)C)c3C2)cc1

$$$$
SWF003448
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003448

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccc2)CC1

$$$$
SWF003449
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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M  END
>  <HTSID>
SWF003449

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CC[C@@]2(C[C@H](Nc3ccccn3)CCO2)C1

$$$$
SWF003450
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003450

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(CC(Oc3cnccn3)CCO2)C1

$$$$
SWF003451
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.3538   -3.7868   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.1628   -3.1991   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8538   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2660   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6728   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2715   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6024   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003451

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)c3csnn3)C2)C1

$$$$
SWF003452
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2258   -3.6684   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8975   -6.7740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2094   -8.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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 10  6  1  1  0  0  0
 11  7  1  1  0  0  0
 12 10  1  6  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003452

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(S(=O)(=O)C4CC4)C[C@@H]32)C(=O)N1

$$$$
SWF003453
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  2  1  6  0  0  0
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  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
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 10 14  1  1  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  6  0  0  0
 23 25  1  6  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  2  0  0  0  0
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 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003453

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1C[C@H]2CCN(C(=O)C3[C@H]4COC[C@@H]34)C[C@@H]2O1

$$$$
SWF003454
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   11.7626   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7663   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5491   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0163   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6264   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1833   -4.4672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0814   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
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 15 19  1  1  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003454

>  <SMILES>
Cc1csc(C(=O)N2C[C@H](C(=O)NCC3CC3)[C@@H]3CCO[C@@H]3C2)c1

$$$$
SWF003455
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.0569    1.2450   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8735    0.7576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8735   -0.7576   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5613    1.5153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1858   -1.5153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5613   -1.5153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8735    2.2729   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2490    2.2729   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5613    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3235    1.7912   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0319    3.7799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9368    1.5153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2490   -0.7576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2717    2.7826   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5141    4.0949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7576   -2.0699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003455

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(C(=O)CC2CC2)CC1

$$$$
SWF003456
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.6090    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9323    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108   -1.5136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -0.0187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -4.5407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1754   -6.0542   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -3.7839   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 18 19  2  0  0  0  0
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 22 25  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003456

>  <SMILES>
COc1ncccc1CN1CCC(C(=O)N(C)C)(n2ccnc2)CC1

$$$$
SWF003457
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
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 10 15  2  0  0  0  0
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 12 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 15 19  1  0  0  0  0
 21 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003457

>  <SMILES>
Cc1cccc(-c2ccc3c(c2)C2(CCOCC2)CN3C(=O)c2ccc(C)o2)c1

$$$$
SWF003458
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -7.3713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003458

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)CC2CC2)C3)n1

$$$$
SWF003459
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003459

>  <SMILES>
O=C(C1CCC1)N1CC2(CC(OCC3CCCC3)CCO2)C1

$$$$
SWF003460
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.2277   -5.4753   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003460

>  <SMILES>
O=C(C1CC1)N1CCC2(CC1)OCCC2CCOCc1cccnc1

$$$$
SWF003461
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
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 21 18  1  1  0  0  0
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 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF003461

>  <SMILES>
Cc1nc(COCC2CC3OCCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3C2)cs1

$$$$
SWF003462
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003462

>  <SMILES>
Cc1cccc(CN2C(=O)CCC23CCN(C(=O)C2CC2)CC3)n1

$$$$
SWF003463
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003463

>  <SMILES>
O=C(NC1CCc2onc(CN3CCOCC3)c2C1)c1ccc(F)cc1

$$$$
SWF003464
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.9211   -2.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  1  0  0  0  0
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 16 18  1  1  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003464

>  <SMILES>
O=C(NC1CCCC1)c1noc2c1CC(NC(=O)C1CCOCC1)CC2

$$$$
SWF003465
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3361   -5.2701   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003465

>  <SMILES>
CCC(=O)NC1CCc2onc(C(=O)NC3CCCC3)c2C1

$$$$
SWF003466
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003466

>  <SMILES>
O=C(c1cccc(Cl)n1)N1CCC2(CC(n3cnnc3)CO2)C1

$$$$
SWF003467
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.8045   -4.1266   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 12 13  2  0  0  0  0
 15 16  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003467

>  <SMILES>
Cc1csc(C(=O)N2Cc3nc(COCc4csc(C)n4)oc3C2)c1

$$$$
SWF003468
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8109    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003468

>  <SMILES>
CC(C)(C)CNC(=O)c1ncn2c1CCC(C(=O)NC1CCC1)C2

$$$$
SWF003469
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    7.9812   -0.2127   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3121    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6211    1.4815   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003469

>  <SMILES>
CN(C)C(=O)[C@@H]1CC[C@@H]2[C@@H](CCN2C(=O)CCc2cncnc2)O1

$$$$
SWF003470
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 11 15  2  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003470

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccncc2)C[C@@H]1Cc1ccccc1

$$$$
SWF003471
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003471

>  <SMILES>
O=C(NCc1ccccn1)[C@H]1CC[C@@H]2[C@@H](CCN2c2ncccn2)O1

$$$$
SWF003472
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9026    0.8675   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5600    1.8647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6939    3.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003472

>  <SMILES>
O=C(Nc1ccncc1)c1nc2c(s1)CCN(C(=O)C1CC1)CC2

$$$$
SWF003473
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  3  1  1  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7 10  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003473

>  <SMILES>
O=C1CCCC2(CCCN(c3ncccn3)C2)N1CCN1CCCC1

$$$$
SWF003474
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.2170   -2.3547   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6944   -1.5498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7007   -0.4321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  3  7  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
  5 11  2  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
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 10 16  2  0  0  0  0
 12 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
  6  9  2  0  0  0  0
 11 16  1  0  0  0  0
 14 19  1  0  0  0  0
 15 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003474

>  <SMILES>
CC(C)Cn1c(C(C)C)nc2c1C1(CCNCC1)Oc1ccccc1-2

$$$$
SWF003475
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003475

>  <SMILES>
Cc1ccccc1S(=O)(=O)NC1CCc2onc(CN3CCCC3)c2C1

$$$$
SWF003476
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -1.3970    5.4113   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9903    4.4978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5781    3.6888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1713    2.7752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003476

>  <SMILES>
CNC(=O)[C@H]1CCC[C@]12CCN(Cc1ccc(F)cc1C)C2

$$$$
SWF003477
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  2  0  0  0  0
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 13 15  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003477

>  <SMILES>
Cc1csc(C(=O)N2CC[C@H]3C(=O)N(c4ccccc4)CCO[C@H]3C2)c1

$$$$
SWF003478
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003478

>  <SMILES>
CN(C)C(=O)NCC1CC12CCN(Cc1cccnc1)CC2

$$$$
SWF003479
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.1779   -4.6723   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003479

>  <SMILES>
CCC(=O)NC1CCc2onc(C(=O)NCc3ccco3)c2C1

$$$$
SWF003480
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
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 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003480

>  <SMILES>
CC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC2CC2)CC1

$$$$
SWF003481
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003481

>  <SMILES>
CCCN(C)C(=O)c1ncn2c1CCC(C(=O)NC(C)C)C2

$$$$
SWF003482
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.0311   -2.6713   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
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 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003482

>  <SMILES>
COCc1ncn2c1CN(Cc1ccc(F)c(F)c1)CCC2

$$$$
SWF003483
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003483

>  <SMILES>
CC(C)CNC(=O)c1ncn2c1CCC(C(=O)NC(C)C)C2

$$$$
SWF003484
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 23 24  1  0  0  0  0
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 14 15  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003484

>  <SMILES>
CC(C)CNC(=O)CC1CC2(CCN(C(C)C)CC2)Oc2ccccc21

$$$$
SWF003485
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 13 15  1  0  0  0  0
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 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003485

>  <SMILES>
O=S(=O)(C1CC1)N1CCOCC2(CN(Cc3ccc(F)c(F)c3)CCO2)C1

$$$$
SWF003486
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 13  2  0  0  0  0
 16 19  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003486

>  <SMILES>
Cn1cnc2c1CC(CNS(C)(=O)=O)N(CC1CCCCC1)C2

$$$$
SWF003487
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.8195    3.1160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 12 15  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003487

>  <SMILES>
O=C1CCC2(CCN(CCc3ccccc3)CC2)N1CC1CC1

$$$$
SWF003488
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    8.0468   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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  4  6  1  0  0  0  0
  9 11  1  0  0  0  0
 22 23  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003488

>  <SMILES>
Cc1ccc(C(=O)N2CCc3sc(CNC(=O)N4CCCC4)cc3C2)o1

$$$$
SWF003489
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003489

>  <SMILES>
CC1CN(c2ncccn2)CCC12CCC(C(=O)Nc1cccnc1)O2

$$$$
SWF003490
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003490

>  <SMILES>
COc1cc(C(=O)N2CCc3ncnc(-c4ccncc4)c3C2)on1

$$$$
SWF003491
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003491

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)CCc4ccc[nH]4)C3)CC2=O)cc1

$$$$
SWF003492
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  3  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 16  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003492

>  <SMILES>
Cn1cc(-c2ncnc3c2CN(C(=O)C2(C#N)CCCC2)CC3)cn1

$$$$
SWF003493
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003493

>  <SMILES>
O=C(NCC1CCC2C1OCCN2C(=O)C1CC1)c1cnccn1

$$$$
SWF003494
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    5.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8 11  1  0  0  0  0
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 12 13  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003494

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC3C(=O)N(C)Cc3ccccn3)C2)C1

$$$$
SWF003495
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.1600   -2.9149   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003495

>  <SMILES>
Cc1nc(C(=O)N2CCc3onc(CN(C)C(C)C)c3C2)cs1

$$$$
SWF003496
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF003496

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CC2)CN(CC(C)C)CCO3)o1

$$$$
SWF003497
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003497

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CCCn2ncc(C(=O)N3CCCC3)c2C1

$$$$
SWF003498
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003498

>  <SMILES>
c1cc2n(n1)C(COCC1CC1)CN(Cc1ccsc1)C2

$$$$
SWF003499
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003499

>  <SMILES>
O=C(CCc1ccccc1F)N1CCc2ncnc(-c3cncnc3)c2C1

$$$$
SWF003500
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 14 19  2  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  3  0  0  0  0
 24 27  2  0  0  0  0
  9 13  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003500

>  <SMILES>
N#Cc1ccc(CC(=O)N2CCc3ncnc(-c4cncnc4)c3C2)cc1

$$$$
SWF003501
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0461    2.1333   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0087    2.7012   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8614    4.1024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003501

>  <SMILES>
CN(C)C(=O)c1nc2c(s1)CCN(C(=O)Cc1noc3ccccc13)CC2

$$$$
SWF003502
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   11.2248   -1.9363   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.5951   -1.3261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2211   -0.8215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4383    0.1656   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.8941   -2.0761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9711    0.4775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003502

>  <SMILES>
COc1ccc(CC(=O)N2CCC3(CC2)CC(=O)N(Cc2csc(C)n2)C3)cc1F

$$$$
SWF003503
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.0805    4.1895   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3896    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8896    4.7773   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3896    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8018    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6986    4.1895   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9774    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003503

>  <SMILES>
Cc1ncsc1CN1CCC2(CCCC2C(=O)NCC2CC2)C1

$$$$
SWF003504
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 13 18  2  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 13  1  0  0  0  0
 14 15  2  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003504

>  <SMILES>
Cc1noc(CC(=O)N2CCc3ncnc(-c4ccccc4)c3C2)n1

$$$$
SWF003505
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003505

>  <SMILES>
O=C(CC1=CCCCC1)N1CC2CN(c3ncccn3)CC2C1

$$$$
SWF003506
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003506

>  <SMILES>
O=C(c1cc2c(s1)CCC2)N1CCC2(CCCN(c3ncccn3)C2)CC1

$$$$
SWF003507
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 10 15  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003507

>  <SMILES>
Cc1ccnc(N2CCCC3(CCCN(C(=O)c4cn(C)cn4)C3)C2)n1

$$$$
SWF003508
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4745    0.2823   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6770    1.3650   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0618    0.2435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003508

>  <SMILES>
Cn1cc(-c2ccc3c(c2)C2(CCN(C(=O)C4CCOC4)C2)CO3)cn1

$$$$
SWF003509
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003509

>  <SMILES>
c1cnc(N2CCC3OCCCC3(COCC3CCOCC3)C2)nc1

$$$$
SWF003510
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003510

>  <SMILES>
O=C(NCc1noc2c1CC(Nc1ncccn1)CC2)C1CC(F)(F)C1

$$$$
SWF003511
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003511

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CCCNC3=O)CC2)cc1

$$$$
SWF003512
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 13 16  2  0  0  0  0
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 16 20  1  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003512

>  <SMILES>
Cn1ccc2cc(C(=O)N3CC4(CC(Oc5ccccn5)CS4)C3)ccc21

$$$$
SWF003513
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003513

>  <SMILES>
COc1ccc(C(=O)N2CC3(CC(N4CCCCC4)CS3)C2)cn1

$$$$
SWF003514
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    8.6451   -2.5092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003514

>  <SMILES>
COc1cc(C(=O)N2CCC3(CC(=O)N(c4ccc(C)cc4)C3)C2)on1

$$$$
SWF003515
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 21 25  1  0  0  0  0
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 28 29  1  0  0  0  0
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 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF003515

>  <SMILES>
O=C(CN1CCCC2(CCCN(S(=O)(=O)c3ccc4c(c3)OCCO4)C2)C1)N1CCCC1

$$$$
SWF003516
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 16  2  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 23 24  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003516

>  <SMILES>
C=CCN1CCOC2CN(C(=O)c3ncnc(C)c3C)CCC2C1

$$$$
SWF003517
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003517

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCCC2(CCC(=O)N2CC2CC2)CC1

$$$$
SWF003518
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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   -0.2010    6.0850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7990    6.0850   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
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 22 23  2  0  0  0  0
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 25 27  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003518

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CCc2ncnc(-c3ccncc3)c2CC1

$$$$
SWF003519
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
   10.9304    2.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0333    4.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333    0.3107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003519

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)Cc3ccc4c(c3)CCCO4)C2)CN1CC1CC1

$$$$
SWF003520
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.1040   -1.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0525   -0.7191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8361   -1.1374   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9700    0.3626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406   -2.1319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7496   -0.7307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9187   -2.3398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5151   -0.1914   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4187   -1.4738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1040    1.8626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9700    2.3626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  6 13  1  0  0  0  0
  7 14  1  0  0  0  0
  8 15  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 13  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003520

>  <SMILES>
CC1(C(=O)N2C3CCC2CN(Cc2cccnc2)C3)CC=CCC1

$$$$
SWF003521
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.0659    7.3635   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6537    6.5545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2469    5.6409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6482    6.6590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8347    4.8319   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003521

>  <SMILES>
O=C(NC1CCC1)C1CC12CCN(C(=O)Cc1ccc(F)cn1)C2

$$$$
SWF003522
Actelion Java MolfileCreator 1.0

 32 35  0  0  0  0  0  0  0  0999 V2000
   -0.4075    2.9301   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3153    3.6211   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9980    4.0318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 30 32  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF003522

>  <SMILES>
O=C(NCC(=O)N1CCCC12CCCN(Cc1cc(F)ccc1F)CC2)c1ccccc1

$$$$
SWF003523
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  1  0  0  0  0
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 20 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
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 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
 28 30  1  0  0  0  0
  5  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 27  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF003523

>  <SMILES>
Cc1noc(C)c1CN1CC2(COCCN(c3ncnc4ccccc34)C2)CC1=O

$$$$
SWF003524
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  9  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003524

>  <SMILES>
Cc1cccc(CN2CCCCC23CCN(Cc2cccnc2)C3)n1

$$$$
SWF003525
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003525

>  <SMILES>
Cn1ccc2cc(C(=O)N3CC4(C3)OCCC4CCNC(=O)c3ccncc3)ccc21

$$$$
SWF003526
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003526

>  <SMILES>
CC1CC(C(=O)N2CCC3(CCCN(Cc4ccncc4)C3=O)CC2)C1

$$$$
SWF003527
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003527

>  <SMILES>
Cc1ncnc(C(=O)N2CCC3(CC2)CC(=O)N(CC2CC2)C3)c1C

$$$$
SWF003528
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  6  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003528

>  <SMILES>
Cn1cc(-c2ncnc3c2CN(C(=O)C2(C)CC=CCC2)CC3)cn1

$$$$
SWF003529
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
    7.0581   -2.5884   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.8188   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
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 10 11  2  0  0  0  0
 12 10  1  1  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
  8  9  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003529

>  <SMILES>
COc1ncc(CN2CC(C(=O)N3CCCC(F)(F)CC3)C3(CCOCC3)C2)cc1C

$$$$
SWF003530
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6503    1.9932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.9447    1.6829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 18 19  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003530

>  <SMILES>
COc1ncccc1CN1CC2(C1)OCCC2CCN1CCCC1

$$$$
SWF003531
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4560   -4.5991   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0705   -2.9104   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7197    0.5790   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  6  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003531

>  <SMILES>
O=C1CCCC2(CN(CC3CC3)CCN(C(=O)c3cc[nH]n3)C2)N1

$$$$
SWF003532
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003532

>  <SMILES>
Cc1ccc(NC2COC3(CCN(C(=O)CC4CC4)C3)C2)nn1

$$$$
SWF003533
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2007    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  2  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  2  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003533

>  <SMILES>
O=C(c1cnn2ccccc12)N1CCc2ncnc(-c3cccnc3)c2C1

$$$$
SWF003534
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 16  1  0  0  0  0
 11 13  2  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003534

>  <SMILES>
CCn1nccc1C(=O)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF003535
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.8238   -1.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6103   -3.7498   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1468   -5.1764   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 16 19  1  0  0  0  0
 20 21  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003535

>  <SMILES>
O=C(NC1CCC1)C1=NOC2(CCN(C(=O)c3cnn4ccccc34)CC2)C1

$$$$
SWF003536
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9113   -1.1153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1170   -2.4544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0858   -2.8692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3229   -3.8407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2482   -4.2199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6763   -4.6035   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8228   -6.3795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003536

>  <SMILES>
Cn1cc(CN2CCCC3(CCC(=O)N3Cc3ccncc3)CC2)cn1

$$$$
SWF003537
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
    0.4701   -8.5675   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4142  -11.4342   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9730  -10.4329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003537

>  <SMILES>
CN(C)CCN1CCOCC2(CCN(C(=O)Cc3cccc(F)c3F)CC2)C1

$$$$
SWF003538
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3433    1.2364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6490    3.3734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9765    0.2002   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9307    1.6457   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8183    1.1851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0834    2.7813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 19 22  2  0  0  0  0
 23 19  1  1  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 11  1  0  0  0  0
 17 21  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003538

>  <SMILES>
O=C(NCc1ccccc1)c1cnn2c1CN(C(=O)C1CCOC1)CCC2

$$$$
SWF003539
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7050    0.3907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5771   -2.2829   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8861   -1.3318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003539

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CCC(C(=O)N3CCCC3)C2)CC1

$$$$
SWF003540
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    5.2437   -3.8385   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2272   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.2326   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4266   -5.3474   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1148   -6.8146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
  7 10  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003540

>  <SMILES>
Cn1cnc(C2CC3(CCCN(CC4CC4)C3=O)CN2C(=O)c2ccccc2)c1

$$$$
SWF003541
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2983    0.2210   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9687    0.7659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7576    0.9364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3563    1.9544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9441    2.7635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9386    2.6589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 11 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003541

>  <SMILES>
O=S(=O)(Cc1ccccc1)N1CC2CCC1C2Oc1ccccn1

$$$$
SWF003542
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    7.8655    0.8899   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4020   -0.5367   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    4.7302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    3.0613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5790    5.8450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 13 19  2  0  0  0  0
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 26 29  2  0  0  0  0
 27 30  2  0  0  0  0
  6  8  2  0  0  0  0
 15 20  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003542

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC2(CC1)c1ccccc1N(CC1CC1)S2(=O)=O

$$$$
SWF003543
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 14 15  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003543

>  <SMILES>
Cc1ccc2c(c1)C1(CCN(C(=O)NC3CCCC3)C1)CO2

$$$$
SWF003544
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.7549   -2.2418   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  6  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003544

>  <SMILES>
O=C(c1ccns1)N1C[C@H]2CCN(c3ncccn3)CC[C@H]2C1

$$$$
SWF003545
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    6.8883   -8.0700   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 10 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF003545

>  <SMILES>
CCC(C)CN1C[C@H]2C(=O)NC3(CCN(S(=O)(=O)c4ccccc4)CC3)[C@H]2C1

$$$$
SWF003546
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
   10.6563   -0.2119   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.2496   -1.1254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
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 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003546

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)Cc3cccc(F)c3)C2)C1

$$$$
SWF003547
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0933   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  1  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 14 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF003547

>  <SMILES>
CNC(=O)CC1CN(S(=O)(=O)c2ccccc2F)Cc2ccnn21

$$$$
SWF003548
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7159   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080   -2.5577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2191    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0602    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1466    1.8757   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2293    3.0782   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2511    2.8702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003548

>  <SMILES>
COCCN1CC[C@]2(CN(C(=O)c3cc[nH]n3)C[C@H]2C)C1=O

$$$$
SWF003549
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4721   -6.4508   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7221   -5.1517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4721   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7221   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  1  0  0  0
 11 13  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003549

>  <SMILES>
O=S(=O)(C1CC1)N1C[C@H]2CCN(c3ncccn3)C[C@H]2C1

$$$$
SWF003550
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347   -2.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -1.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128   -3.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128   -2.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9073   -2.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
  7 12  1  0  0  0  0
 15 19  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003550

>  <SMILES>
CN1CCC2(CC1)C(=O)N(c1cnn(C)c1)CCN2CC1CC1

$$$$
SWF003551
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846   -3.1317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -4.5583   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7380   -5.9286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8399   -4.4015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6196   -7.1421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7215   -5.6150   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0095   -8.5124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1114   -6.9853   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5178   -8.6692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8912   -9.7260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003551

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(C(C)C)C3)C2)cc1

$$$$
SWF003552
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2532   -3.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8712   -3.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622   -4.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622   -4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9744   -5.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003552

>  <SMILES>
CN(C)Cc1cncc2c1CCN(C(=O)c1ncn(C)n1)C2

$$$$
SWF003553
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003553

>  <SMILES>
COc1ccc(CN2C(=O)CCC23CCN(C(=O)c2cc[nH]c2)CC3)cc1

$$$$
SWF003554
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003554

>  <SMILES>
O=C1N(Cc2ccncc2)CCC12CCCN(Cc1ccoc1)C2

$$$$
SWF003555
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.3538   -3.7868   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1139   -3.5081   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003555

>  <SMILES>
Cc1nc(C(=O)N2CC[C@]3(C2)C[C@H](NC(=O)N(C)C)C3)cs1

$$$$
SWF003556
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 15  1  6  0  0  0
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 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003556

>  <SMILES>
O=C(C[C@@H]1COC[C@H]2CN(Cc3cccnc3)C[C@@H]12)NCC1CC1

$$$$
SWF003557
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 21 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
 23 24  2  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003557

>  <SMILES>
O=C(/C=C/c1cccs1)N1CCC2(CC1)OC(C(=O)N1CCOCC1)Cn1ccnc12

$$$$
SWF003558
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003558

>  <SMILES>
O=C(c1cccc(O)c1)N1Cc2ccnn2C(C(=O)N2CCC(F)(F)CC2)C1

$$$$
SWF003559
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.6840   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7329   -1.7340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 23 26  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003559

>  <SMILES>
Cc1cc(OC[C@H]2CO[C@@H]3CN(C(=O)c4ccccc4)C[C@H]23)cc(C)n1

$$$$
SWF003560
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    5.0360   -0.3752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 20  1  0  0  0  0
  8 10  1  0  0  0  0
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 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003560

>  <SMILES>
Cc1csc(C(=O)N2C[C@H]3CCN(S(C)(=O)=O)[C@H]3C2)c1

$$$$
SWF003561
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -0.1506    0.0675   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0573    1.0456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
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 21 23  2  0  0  0  0
 10 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF003561

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)c1ncc(OC)cn1)C2

$$$$
SWF003562
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003562

>  <SMILES>
CN1CCCCC1C1CCN(C(=O)c2cnc(Cl)cc2Cl)CC1

$$$$
SWF003563
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003563

>  <SMILES>
CCN(C)C(=O)c1ncn2c1CCC(C(=O)NC1CCC1)C2

$$$$
SWF003564
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 23  1  0  0  0  0
 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003564

>  <SMILES>
COc1ccc(CNC(=O)C2Cn3ccnc3C3(CCN(C(C)C)CC3)O2)cc1

$$$$
SWF003565
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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  7 11  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003565

>  <SMILES>
CC(=O)c1cc(C(=O)N2CCC3(CC2)CCN(c2ncccn2)C3)n[nH]1

$$$$
SWF003566
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  6  0  0  0
 12 15  2  0  0  0  0
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 16 18  1  0  0  0  0
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 27 29  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003566

>  <SMILES>
O=S(=O)(c1ccccc1)N1CCC(c2nc3ccc(N4CCOCC4)cn3n2)C1

$$$$
SWF003567
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF003567

>  <SMILES>
O=C(Nc1ccccc1)C1=NOC2(CCCN(C(=O)c3cc[nH]n3)C2)C1

$$$$
SWF003568
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1340    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    6.0029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003568

>  <SMILES>
CC1(C(=O)N2CC3CCN(c4cnccn4)CC3C2)CC=CCC1

$$$$
SWF003569
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003569

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CCCN(Cc4ccncc4)C3=O)CC2)o1

$$$$
SWF003570
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4543   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9461   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5727   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1828   -9.2484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0809   -7.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3011  -10.4620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1992   -8.9349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8093  -10.3052   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  6  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003570

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)C4(C)CC=CCC4)CC3)CC2=O)cs1

$$$$
SWF003571
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3289    1.4318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003571

>  <SMILES>
CCOC1COC2(CCCN(C(=O)c3ccc(CC)nc3)C2)C1

$$$$
SWF003572
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.7473   -6.9100   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF003572

>  <SMILES>
O=C(c1ccco1)N1CCC(c2nnc3ccc(-c4ccsc4)nn23)CC1

$$$$
SWF003573
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  1  0  0  0  0
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 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003573

>  <SMILES>
CC1(C(=O)N2CCCn3nnc(CN4CCCCC4)c3C2)CC=CCC1

$$$$
SWF003574
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    5.6038   -1.2338   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6530    4.7301   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  2  0  0  0  0
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  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6 10  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 21 24  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003574

>  <SMILES>
Cn1cc(-c2cnc3c(N4CCN(C5CCC5)CC4)nccn23)cn1

$$$$
SWF003575
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.1471    3.4054   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003575

>  <SMILES>
COCCN1CCCC12CCCN(C(=O)c1cc[nH]n1)CC2

$$$$
SWF003576
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 15  2  0  0  0  0
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 18 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
 11 13  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 23 24  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003576

>  <SMILES>
O=C(Cc1ccccc1)NC1CC2(CCN(Cc3cccnc3)CC2)c2ccccc21

$$$$
SWF003577
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003577

>  <SMILES>
Cc1cnc(N2CCC3(CCN(C(=O)c4ccco4)C3)CC2)nc1

$$$$
SWF003578
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.9282   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 19 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003578

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CCN(Cc3cccnc3)CC2)CC1

$$$$
SWF003579
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.1471    3.4054   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1070    3.1250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3440    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8297    3.8160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5716    1.5183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3222    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8137    3.6375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6955    4.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5866    0.5185   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7695    1.0512   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2875    4.5181   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5965    5.2409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3491    0.1438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003579

>  <SMILES>
COCCN1CCCC12CCCN(C(=O)c1cc[nH]c1)CC2

$$$$
SWF003580
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003580

>  <SMILES>
c1cncc(OCC23CCCOC2CCN(CC2CCOCC2)C3)c1

$$$$
SWF003581
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003581

>  <SMILES>
Cn1cc(C(=O)NC2CCOC3(CCN(C(=O)Cc4ccccc4)CC3)C2)cn1

$$$$
SWF003582
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003582

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1Cc1cccnc1

$$$$
SWF003583
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003583

>  <SMILES>
Cc1ccc(CN2CCCC3(CC(n4cnnc4)CO3)C2)s1

$$$$
SWF003584
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.1674   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003584

>  <SMILES>
Cn1cc(CN2CCOC3C(Cn4cccc4)CCC32)cn1

$$$$
SWF003585
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7014   -8.9692   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2014   -8.9692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003585

>  <SMILES>
O=C(NCC1CC1)c1ccc2n1CCN(C(=O)c1ccsc1)CC2

$$$$
SWF003586
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF003586

>  <SMILES>
O=C(C1CCc2[nH]ncc2C1)N1CCN(c2ccccn2)CC1

$$$$
SWF003587
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.6425    5.1731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003587

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CC2CCCC(N(C)Cc3ccncc3)C2C1

$$$$
SWF003588
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003588

>  <SMILES>
CC1CC1C(=O)N1CC2(C1)OCCC2CCNC(=O)c1ccncc1

$$$$
SWF003589
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
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 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003589

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CCc2ncnc(N3CCOCC3)c2CC1

$$$$
SWF003590
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  1  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
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 24 27  1  0  0  0  0
 11 16  1  0  0  0  0
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 19 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF003590

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CCCC2(CCCN(Cc3ccnn3C)C2)C1

$$$$
SWF003591
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.7891    3.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    3.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003591

>  <SMILES>
C=CCOCC12CCCOC1CCN(Cc1nccs1)C2

$$$$
SWF003592
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF003592

>  <SMILES>
CCN1CCC2(CCN(C(=O)c3cccs3)CC2)CC1=O

$$$$
SWF003593
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003593

>  <SMILES>
Cc1ccnc(N2CCCC3(CCCN(C(=O)c4cncnc4)C3)C2)n1

$$$$
SWF003594
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 11 13  2  0  0  0  0
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 25 28  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 21  1  0  0  0  0
 26 28  2  0  0  0  0
M  END
>  <HTSID>
SWF003594

>  <SMILES>
Cn1nccc1C(=O)N1CCCC(c2nc3ccc(-c4cccs4)cn3n2)C1

$$$$
SWF003595
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003595

>  <SMILES>
CC1CC(C(=O)N2CCc3nc(C(=O)N4CCCCC4)sc3CC2)C1

$$$$
SWF003596
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003596

>  <SMILES>
Cc1cccc(CN2Cc3ccnn3C(CCN3CCCC3=O)C2)c1

$$$$
SWF003597
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6  8  1  0  0  0  0
 15 14  1  1  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003597

>  <SMILES>
Cc1ccsc1CN1CCCC2(CC(C(=O)Nc3cccc(Cl)c3)=NO2)C1

$$$$
SWF003598
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  6 10  2  0  0  0  0
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  8 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003598

>  <SMILES>
O=C(Nc1cccnc1)c1ncn2c1CCC(C(=O)N1CCOCC1)C2

$$$$
SWF003599
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
 17 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003599

>  <SMILES>
Cc1csc(C(=O)N2CCCn3ncc(C(=O)NC4CCCC4)c3C2)c1

$$$$
SWF003600
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.3461   -2.0092   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6770   -1.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  8  1  6  0  0  0
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 13 15  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003600

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CC(=O)N(c3ccsc3)C2)C1

$$$$
SWF003601
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003601

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CC1)CN(Cc1nccs1)CCO2

$$$$
SWF003602
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003602

>  <SMILES>
CC(C)CN1CCC2(C1)CN(C(=O)Cc1ccc(F)cn1)C2

$$$$
SWF003603
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.8695   -5.3885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1264   -4.7194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003603

>  <SMILES>
COCCNC(=O)c1ccc2n1CCN(C(=O)c1cc[nH]n1)CC2

$$$$
SWF003604
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.1375   -5.3885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003604

>  <SMILES>
O=C(NCc1ccccc1)c1ccc2n1CCN(C(=O)c1cc[nH]c1)CC2

$$$$
SWF003605
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003605

>  <SMILES>
O=C1COC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1Cc1cccnc1

$$$$
SWF003606
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
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 25 28  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003606

>  <SMILES>
C=CCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccccn1)C2

$$$$
SWF003607
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.7121    4.1073   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 11  8  1  6  0  0  0
 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003607

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CC(=O)N(c3ccsc3)C2)C1

$$$$
SWF003608
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  6  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003608

>  <SMILES>
O=S(=O)(c1ccc2c(c1)CCO2)N1CC2(CC(N3CCCC3)CS2)C1

$$$$
SWF003609
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.8971    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    9.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003609

>  <SMILES>
COCCCN1CCCC2(CCCN(C(=O)c3ncccc3C)C2)C1

$$$$
SWF003610
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    8.6537   -2.0932   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5492   -1.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7402   -2.4999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0711   -1.7567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003610

>  <SMILES>
O=C(NC1CC1)C1=NOC2(CCN(C(=O)c3ccsc3)CC2)C1

$$$$
SWF003611
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -3.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2942   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5442   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003611

>  <SMILES>
O=C(C1CN(Cc2ccsc2)Cc2ccnn21)N1CCC(F)(F)CC1

$$$$
SWF003612
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.3596   -5.9087   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3814   -6.1166   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5506   -4.5075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8814   -5.2506   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3426   -3.5293   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0372   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6230   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003612

>  <SMILES>
Cc1ncsc1CN1CC2(CC(COCc3cccnc3)CCN2C)C1

$$$$
SWF003613
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.2582    3.5103   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0014    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    1.8630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9524    3.1502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7615    2.5624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2615    4.1013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6345    0.5759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3287    0.2158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5705    3.1502   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2615    4.1013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003613

>  <SMILES>
CN(C)CCN1CCCC12CCN(C(=O)c1cc[nH]c1)CC2

$$$$
SWF003614
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.3882   -1.5715   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7781   -2.9418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8800   -1.7283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3109   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8928   -3.9455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1919   -3.1955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090   -4.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3371   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5871   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
  9 11  2  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003614

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCn2c(-c3cccs3)cnc2C1

$$$$
SWF003615
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003615

>  <SMILES>
CCc1ccc(C(=O)N2CCc3c(CN(C)C)cncc3C2)cn1

$$$$
SWF003616
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.6603   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003616

>  <SMILES>
C=CCOCc1cncc2c1CCN(C(=O)c1cccc(C)n1)C2

$$$$
SWF003617
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 28 29  1  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003617

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CCC(=O)N(Cc4cccnc4)C3)CC2)cc1

$$$$
SWF003618
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.6494   -4.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6275   -4.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1494   -3.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8185   -3.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003618

>  <SMILES>
Cn1c(C(=O)N2CCc3ncnc(-c4ccsc4)c3C2)cccc1=O

$$$$
SWF003619
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.8993   -8.0240   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5903   -7.0730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0903   -8.6118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1781   -6.2640   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5903   -7.0730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2813   -8.0240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1726   -6.3685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7714   -5.3504   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3303   -8.3331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6022   -3.7413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6887   -4.1480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 19 21  2  0  0  0  0
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 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
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  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003619

>  <SMILES>
Cc1csc(C(=O)N2CCC3(CCc4nnc(C(=O)NCC5CC5)n4CC3)C2)c1

$$$$
SWF003620
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
    7.0989    2.7254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6922    3.6389   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2800    4.4480   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0285    3.0003   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 30 32  2  0  0  0  0
 10 11  2  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF003620

>  <SMILES>
O=C(NC1CCCCC1)c1nnc2n1CCC1(CC2)CCN(C(=O)Cc2ccccc2)C1

$$$$
SWF003621
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    5.1726   -6.3685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1781   -6.2640   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7714   -5.3504   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4093   -8.7955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003621

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CCC1(CC2)CCN(C(=O)c2ccccc2)C1

$$$$
SWF003622
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4543   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9461   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5727   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0362   -9.3047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0727   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8227  -10.1864   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 28 30  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 27  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003622

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cnn4ccccc34)CC2)CN1Cc1cccc(F)c1

$$$$
SWF003623
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5903    5.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3031    6.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5684    4.9151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2813    6.0741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2375    5.6583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8774    3.9641   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8556    3.7561   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 18 20  2  0  0  0  0
 22 24  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003623

>  <SMILES>
Cn1nccc1C(=O)N1CCC(c2nnc3ccc(-c4ccccc4)nn23)CC1

$$$$
SWF003624
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5240    2.1133   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9417    2.8178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9362    2.9223   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003624

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(C(=O)c1cc[nH]n1)C2

$$$$
SWF003625
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933  -10.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003625

>  <SMILES>
Cc1cccc(CN2CCCC3(CCN(C(=O)C4CC4C)CC3)C2=O)n1

$$$$
SWF003626
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6505   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0404   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7688   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9221   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2770   -7.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3789   -9.2484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9385   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3953   -8.9349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4972  -10.4620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0054  -10.3052   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003626

>  <SMILES>
CN(Cc1cccnc1)CC1CC2(CCN(C(=O)c3ccccc3)CC2)CO1

$$$$
SWF003627
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2350   -1.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2350   -0.1340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2350   -0.1340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7350    0.7321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2350    1.5981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2350    1.5981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  7  9  1  0  0  0  0
 11 12  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003627

>  <SMILES>
COCCN1CCC2CN(C(=O)c3ccccc3C)CC2C1=O

$$$$
SWF003628
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8528    1.2364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5472    3.3734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8110    7.1364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 17 15  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 30 31  1  0  0  0  0
  9 10  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003628

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CCc4nnc(C(=O)NCC5CC5)n4CC3)C2)cc1

$$$$
SWF003629
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003629

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CCC2(CCCCN2C)CC1

$$$$
SWF003630
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   16.1464    5.1666   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   15.9896    3.6748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4814    3.5180   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   15.8328    2.1830   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.4978    3.8316   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8877    5.2019   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.6161    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3959    5.3587   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1243    2.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5142    4.1452   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    1.5613   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7509    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8528    0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9711   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4793   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF003630

>  <SMILES>
CCCNC(=O)C1=NOC2(CCCN(c3cc(C(F)(F)F)ncn3)C2)C1

$$$$
SWF003631
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.2005    2.1138   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8696    1.3707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3915    0.7126   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3696    0.5047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003631

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)c3cccs3)CC2)C1)c1cccnc1

$$$$
SWF003632
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.3323   -2.5607   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6450   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5844   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128    0.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1027    4.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6027    4.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003632

>  <SMILES>
O=C(NCC1OCCc2cn(Cc3ccccc3)nc21)C1CC(F)C1

$$$$
SWF003633
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    4.3301    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757    2.5933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    3.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8053   -0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6449    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4041   -1.4781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1449    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6449    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  2  0  0  0  0
 21 22  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF003633

>  <SMILES>
O=C(CC1CN(C(=O)c2cc3ccccc3[nH]2)Cc2ccnn21)NCc1ccco1

$$$$
SWF003634
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7161    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9071    3.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5103    3.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5158    3.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9170    4.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3292    5.0704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7360    5.9840   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3347    4.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1482    6.7930   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    5.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1537    6.6885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003634

>  <SMILES>
CC(C)NC(=O)C1CN(C(=O)Cc2ccccn2)C2CCOC12

$$$$
SWF003635
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.0752    2.5340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0697    2.4295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4765    1.5159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6575    3.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9765    0.6499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4546    1.3080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6520    3.1339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2508    4.1520   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5591    0.3135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398    3.9430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8386    4.9610   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8331    4.8565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003635

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CCCC2C(=O)N2CCCCO2)C1

$$$$
SWF003636
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5377   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6990   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0514   -3.1283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -4.4155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3083   -3.7974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4672   -5.0846   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5162   -4.7756   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3572   -3.4884   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 25 28  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 26 28  2  0  0  0  0
M  END
>  <HTSID>
SWF003636

>  <SMILES>
Cc1cccc(C(=O)N2CC3(C2)OCCC3CCNC(=O)c2ccnn2C)c1

$$$$
SWF003637
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7216    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4746    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0820    3.3692   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6242    4.0712   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    4.3601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8048    2.6781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3153    4.7940   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  1  0  0  0  0
 17 23  1  0  0  0  0
 18 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 12  1  0  0  0  0
 19 24  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003637

>  <SMILES>
COc1ccc(CCC(=O)N2CCCC3(CCCN3C)CC2)c(OC)c1

$$$$
SWF003638
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958   -2.5590   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5240    2.1133   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9417    2.8178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9362    2.9223   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003638

>  <SMILES>
CN1CC(=O)N(c2cccnc2)CC12CCN(C(=O)c1cc[nH]c1)C2

$$$$
SWF003639
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.8585    3.3792   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3585    2.5132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003639

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)c3cc[nH]c3)CCC21

$$$$
SWF003640
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003640

>  <SMILES>
O=C(c1cc[nH]c1)N1CCCn2nnc(CN3CCCC3)c2C1

$$$$
SWF003641
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003641

>  <SMILES>
c1cnc(N2CCCC3(CC2)CN(Cc2cccs2)CCO3)nc1

$$$$
SWF003642
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 12  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003642

>  <SMILES>
CC1CCC(C(=O)N2C3CCC2CN(Cc2cccnc2)C3)CC1

$$$$
SWF003643
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003643

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)Cc3ccccc3)CC2)C1)c1ccnnc1

$$$$
SWF003644
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.1040   -1.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8361   -1.1374   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1040    1.8626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1040    3.8626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
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 13 16  2  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 24  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003644

>  <SMILES>
CCc1ccc(C(=O)N2C3CCC2CN(Cc2cccnc2)C3)cn1

$$$$
SWF003645
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.4848   -2.6667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003645

>  <SMILES>
CC(C)CN1CC2CN(C(=O)Cc3ccc(F)cn3)CC(C1)O2

$$$$
SWF003646
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.9282   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2532   -4.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003646

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CCN(Cc4cccnc4)CC3)CC2)o1

$$$$
SWF003647
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   10.7173    7.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  1  0  0  0  0
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 24 26  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003647

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CC1)CN(C(=O)c1ccsc1)CCO2

$$$$
SWF003648
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
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  7  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
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 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003648

>  <SMILES>
c1ccc(NCCC2CN(Cc3cccnc3)Cc3cccn3C2)nc1

$$$$
SWF003649
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -8.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003649

>  <SMILES>
Cc1ccc(CN2CCOC3(CCN(C(=O)c4cc[nH]c4)CC3)C2)cc1

$$$$
SWF003650
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5349    1.9042   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7864    0.4566   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6172    2.0658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6999    0.8633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003650

>  <SMILES>
O=C(c1ccco1)N1CCCC2(CCN(C(=O)C3CC(O)C3)C2)C1

$$$$
SWF003651
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003651

>  <SMILES>
O=C(c1ccsc1)N1CCC2CN(Cc3ccncc3)CC21

$$$$
SWF003652
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003652

>  <SMILES>
Cc1nc(CN2CC3CN(C(=O)C4CC(C)C4)CC3C2)cs1

$$$$
SWF003653
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9721   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4639   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8322   -5.4240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.5023   -5.3031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003653

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cccs3)CC2)CN1CC1CC1

$$$$
SWF003654
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.7986   -7.4458   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0121   -6.5641   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5851   -6.5641   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4303   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9221   -4.0808   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9405   -0.6445   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003654

>  <SMILES>
CC(C)NC(=O)C1CN(C(=O)c2ccsc2)C2CCOC12

$$$$
SWF003655
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1235    2.4433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 20 21  1  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003655

>  <SMILES>
CC1(C(=O)N2CCc3ncc(CN4CCOCC4)n3CC2)CC=CCC1

$$$$
SWF003656
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003656

>  <SMILES>
O=C1CC2(CCN1CC1CCC1)CCN(C(=O)c1cccs1)CC2

$$$$
SWF003657
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  1  0  0  0  0
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 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003657

>  <SMILES>
O=C(Cc1ccccc1)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF003658
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003658

>  <SMILES>
CC1CC1C(=O)N1CCC2(CCCN(c3ncccn3)C2)CC1

$$$$
SWF003659
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    7.0581   -2.5884   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
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 13 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  8  9  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003659

>  <SMILES>
CCn1cc(CN2CC(C(=O)N3CCCC(F)(F)CC3)C3(CCOCC3)C2)cn1

$$$$
SWF003660
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   16.8824   -4.1311   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   15.7677   -3.1275   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1943   -2.6639   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.9508   -1.8694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5097   -3.9444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6928   -2.6864   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2255   -2.3745   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7620   -0.9480   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.2218   -3.4893   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7546   -3.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6854   -4.9158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7509   -4.2921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6817   -6.0306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2837   -3.9802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2145   -5.7187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2800   -5.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8128   -4.7831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3493   -3.3565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003660

>  <SMILES>
CCNC(=O)c1cnn2c(C3CCCN(C(=O)C4CC(F)(F)C4)C3)ccnc12

$$$$
SWF003661
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5192   -1.8799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9012   -3.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1883   -2.6230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8793   -3.5741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5485   -4.3172   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2394   -5.2683   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5266   -4.1093   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1957   -4.8525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8356   -3.1583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1739   -4.6445   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8138   -2.9503   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4829   -3.6935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003661

>  <SMILES>
O=C(Nc1ccccc1)c1ncn2c1CCC(C(=O)N1CCCCC1)C2

$$$$
SWF003662
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3272   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0182   -4.6723   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6060   -5.4814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0672   -4.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0182   -6.2904   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0672   -5.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003662

>  <SMILES>
Fc1ccc(CN2CCOC3C(Cn4cccc4)CCC32)cc1F

$$$$
SWF003663
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    6.9282    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5263    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 15 18  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF003663

>  <SMILES>
Cc1ccc(C(=O)N2CC3CCCC(C2)C3CC(=O)NCc2ccco2)cn1

$$$$
SWF003664
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    0.8465    4.3195   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 26 28  2  0  0  0  0
  5  6  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003664

>  <SMILES>
O=C1CCC2(CCCN(c3ncnc4ccsc34)CC2)N1Cc1ccccc1

$$$$
SWF003665
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003665

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CCC(C(=O)Nc4cccnc4)O3)C(C)C2)cn1

$$$$
SWF003666
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 15  1  0  0  0  0
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 11 15  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003666

>  <SMILES>
O=C(NC1CCCn2cnc(-c3ccccc3)c21)C1CCOCC1

$$$$
SWF003667
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003667

>  <SMILES>
O=C(C1CC1)N1CCC2(CCCN(Cc3ccccn3)C2)CC1

$$$$
SWF003668
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003668

>  <SMILES>
O=C(Nc1ccccc1)c1ncn2c1CN(C(=O)C1CC(O)C1)CCC2

$$$$
SWF003669
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003669

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF003670
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.0524   -6.6646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6821   -7.2747   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4423   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5442   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1543   -8.1917   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4259   -5.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5278   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003670

>  <SMILES>
O=S(=O)(c1ccccn1)N1CCC2(CC1)COC(CN1CCCC1)C2

$$$$
SWF003671
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.5112   -8.2438   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1045   -7.3302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6922   -6.5212   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1099   -7.2257   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2855   -5.6077   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7032   -6.3122   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2910   -5.5031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8842   -4.5896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4720   -3.7806   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4665   -3.8851   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0653   -2.8670   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0708   -2.7625   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6531   -2.0580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003671

>  <SMILES>
CC(C)NC(=O)C1CC2CN(C(=O)Cc3ccc(F)cn3)CC1O2

$$$$
SWF003672
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  1  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003672

>  <SMILES>
CC(=O)N1Cc2cn(CC3CC3)nc2C(COCC2CC2)C1

$$$$
SWF003673
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0362   -9.3047   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003673

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)CC(=O)N(Cc2cccc(F)c2)C3)o1

$$$$
SWF003674
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.3515    5.9146   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4698    7.1281   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2496    4.3875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230    3.3308   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3130    8.6199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0995    7.7382   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0129    1.9604   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003674

>  <SMILES>
CC1CN(S(=O)(=O)C2CC2)CCC12CCC(C(=O)Nc1cccnc1)O2

$$$$
SWF003675
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 28 31  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  2  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003675

>  <SMILES>
Cc1cccc(C(=O)N2CC3Cc4nnc(C(=O)Nc5cccc(F)c5)n4CC3C2)n1

$$$$
SWF003676
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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 23 26  1  0  0  0  0
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 26 28  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  2  0  0  0  0
 13 15  1  0  0  0  0
 20 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003676

>  <SMILES>
Cc1ccc(-c2cnc3n2C2(CCN(Cc4cccnc4)CC2)COC3)cc1

$$$$
SWF003677
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 10 15  2  0  0  0  0
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 14 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
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 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003677

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)CN(C(=O)N1CCCC1)c1ccccc12

$$$$
SWF003678
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003678

>  <SMILES>
COc1cccc(C(=O)N2CC3CCC2C3Oc2ccccn2)c1

$$$$
SWF003679
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003679

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CCOCC3NC(=O)CC3CC3)CC2)n1

$$$$
SWF003680
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6109   -3.0328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  6  3  1  1  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
 22 26  2  0  0  0  0
 23 27  2  0  0  0  0
  8 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003680

>  <SMILES>
c1cncc(OCC2CN(Cc3cccc4[nH]ccc34)Cc3ccnn32)c1

$$$$
SWF003681
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.6804    0.4656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003681

>  <SMILES>
O=c1cc(CN2CCCC2)nc2n1CCCN(Cc1cccs1)C2

$$$$
SWF003682
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1084   -3.7496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1517   -5.0097   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4607   -4.0586   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  2  0  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003682

>  <SMILES>
N#Cc1cccc(CN2CCc3ncc(Cn4cccn4)n3CC2)c1

$$$$
SWF003683
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2873   -0.3138   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2819   -0.2092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5185    2.2178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 17 22  2  0  0  0  0
 19 23  1  0  0  0  0
 19 24  1  0  0  0  0
 20 25  2  0  0  0  0
 21 26  1  0  0  0  0
 23 27  1  0  0  0  0
 24 28  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 18 22  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003683

>  <SMILES>
COc1cccc(NC2COC3(CCN(Cc4cccnc4OC)CC3)C2)c1

$$$$
SWF003684
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003684

>  <SMILES>
O=C(CC1(O)CCC1)N1CCc2ncnc(-c3ccccc3)c2C1

$$$$
SWF003685
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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  5 10  1  0  0  0  0
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 10 15  1  0  0  0  0
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 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
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 14 19  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003685

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)Cc1ccccc1CN(CC1CC1)C2=O

$$$$
SWF003686
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003686

>  <SMILES>
Cn1cc(C2COC3(CCN(Cc4ccsc4)CC3)C2)cn1

$$$$
SWF003687
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  6  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003687

>  <SMILES>
O=C(c1ccns1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF003688
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003688

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)C4CC(F)(F)C4)C3)Oc3ccccc3S2(=O)=O)cc1

$$$$
SWF003689
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8298   -3.7762   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.6750   -6.4163   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003689

>  <SMILES>
Cc1ccc(CN2CCC3C2CCN3CC2CCOCC2)o1

$$$$
SWF003690
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   10.3923   -5.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003690

>  <SMILES>
O=C(C1CC1)N1CCOC2(CCCN(c3cccc(F)c3)C2)C1

$$$$
SWF003691
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8852   -3.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  8  1  0  0  0  0
 15 14  1  1  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003691

>  <SMILES>
CC(C)N1CCCC2(CC(C(=O)Nc3cccc(Cl)c3)=NO2)C1

$$$$
SWF003692
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7204   -1.6570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6083   -4.4191   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003692

>  <SMILES>
O=C(NCC1CCC2(COCCN(C(=O)C3CC3)C2)O1)c1ccnnc1

$$$$
SWF003693
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
  9 14  1  0  0  0  0
 15 16  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003693

>  <SMILES>
CN1CCC2(CCCN(C(=O)Cc3noc4ccccc34)C2)CC1

$$$$
SWF003694
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.0353    5.3460   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003694

>  <SMILES>
CN(C)S(=O)(=O)N1CCC2(CCC2NC(=O)c2cccn2C)CC1

$$$$
SWF003695
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003695

>  <SMILES>
Cn1cccc1C(=O)N1CCC2(CC(C(=O)Nc3cccnc3)=NO2)C1

$$$$
SWF003696
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.3923   -5.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
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  7 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  6  8  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003696

>  <SMILES>
Cc1ccc(C(=O)N2CCOC3(CCCN(c4cccc(F)c4)C3)C2)cn1

$$$$
SWF003697
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    3.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9019    0.8068   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003697

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CC2OCCN(Cc3ccncc3)C2C1

$$$$
SWF003698
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.0158    3.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0103    3.2139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4170    4.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2891    1.4538   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3952    4.3353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003698

>  <SMILES>
O=C(Nc1cccnc1)C1CC12CCN(C(=O)N1CCCC1)C2

$$$$
SWF003699
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8599   -4.7641   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003699

>  <SMILES>
Cn1cc(CN2CC3(CCN(S(=O)(=O)C4CC4)C3)C2)cn1

$$$$
SWF003700
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.3176   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
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 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003700

>  <SMILES>
COCC(=O)N1CCCC2(CCN(Cc3ccncc3)C2=O)C1

$$$$
SWF003701
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003701

>  <SMILES>
c1cncc(CN2CCC3(CC2)CCN(Cc2cccnc2)C3)c1

$$$$
SWF003702
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  7  8  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003702

>  <SMILES>
O=C(NCC1OCCc2cn(Cc3ccccc3)nc21)C1(c2ccccc2)CC1

$$$$
SWF003703
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003703

>  <SMILES>
O=C(NC1CCCCC1)c1nnc2n1CCC1(CC2)CCN(C(=O)c2ccccc2)C1

$$$$
SWF003704
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 17 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003704

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CCc2ncnc(-c3ccccc3)c2C1

$$$$
SWF003705
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003705

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CCCN(C(=O)c3cscn3)C2)CC1

$$$$
SWF003706
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   10.3923    9.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003706

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CCCN(Cc3cccc(F)c3)C2=O)CC1

$$$$
SWF003707
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1314    2.2739   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003707

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(C2)CN(C)c2cccnc23)s1

$$$$
SWF003708
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4526   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8539   -6.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8648   -5.9566   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  1  1  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
 23 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003708

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(C(=O)N2CCCC2)c2ccccc23)cn1

$$$$
SWF003709
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.2813   -1.0986   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3031   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3858   -2.0932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8964    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4722   -2.4999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9018    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4951    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5006    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF003709

>  <SMILES>
CC(C)NC(=O)CC1COC2(CCN(Cc3nccs3)CC2)C1

$$$$
SWF003710
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7480   -1.7592   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7741    4.4758   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.6642    7.8659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003710

>  <SMILES>
Cn1cc(-c2ccc3c(c2)C2(CCN(C(=O)c4csnn4)C2)CO3)cn1

$$$$
SWF003711
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4817    5.1305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  2  0  0  0  0
 23 25  3  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 24  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003711

>  <SMILES>
N#Cc1cccc(C(=O)N2CC3(CC(OCC4CCCC4)CS3)C2)c1

$$$$
SWF003712
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003712

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CCc2ncnc(-c3ccsc3)c2C1

$$$$
SWF003713
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003713

>  <SMILES>
O=C(c1csnn1)N1CCC2(COc3ccc(-c4ccccc4)cc32)C1

$$$$
SWF003714
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  6  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 27 29  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003714

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)N3CCCC3)CC2)c2ccccc21)NC1CCC1

$$$$
SWF003715
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003715

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccccc3)CC2)CN1Cc1cccc(F)c1

$$$$
SWF003716
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
   10.6484    4.0881   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 18 16  1  1  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
 10 11  2  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF003716

>  <SMILES>
O=C(NC1CCCC1)c1nnc2n1CCC1(CC2)CCN(C(=O)Cc2ccccc2)C1

$$$$
SWF003717
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003717

>  <SMILES>
Cc1ccc(CN2CCCC3(CCN(C(=O)C4CC4)CC3)C2)cc1

$$$$
SWF003718
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.3923   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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M  END
>  <HTSID>
SWF003718

>  <SMILES>
CC(=O)N1CCC2(CCCN(C(=O)c3ccccc3-c3ccccc3)C2)CC1

$$$$
SWF003719
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3359   -8.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 21 24  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003719

>  <SMILES>
Cc1cccc(CNC2CCc3onc(CNS(C)(=O)=O)c3C2)c1

$$$$
SWF003720
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003720

>  <SMILES>
C[C@@H]1CN(C(=O)C2CC2)C[C@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF003721
Actelion Java MolfileCreator 1.0

 26 31  0  0  0  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1908   -1.8611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7670    3.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2463    4.5579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
  8 12  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 23 26  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003721

>  <SMILES>
O=C(N1CCC2(CC1)Cc1nccn1-c1ccccc1O2)C12CC(C1)C2

$$$$
SWF003722
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003722

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3COC[C@]3(COc3ccccn3)C2)cn1

$$$$
SWF003723
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003723

>  <SMILES>
Cn1cccc1C(=O)N1CCC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF003724
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 11  1  6  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003724

>  <SMILES>
CCS(=O)(=O)N1CCC(C2CCCCN2C(=O)C2CCC2)CC1

$$$$
SWF003725
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5358    0.9115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3548    2.6341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5303    1.0160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1291   -0.0021   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3493    2.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003725

>  <SMILES>
Cc1ccccc1C(=O)N1CC[C@]2(CCC[C@@H](CN3CCCC3)O2)C1

$$$$
SWF003726
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.4469   -4.6158   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0203   -4.1523   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7085   -2.6851   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9056   -5.1560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5254   -1.4271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4505   -1.8681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4790   -4.6925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2175   -6.6232   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3643   -5.6962   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1028   -7.6269   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6762   -7.1634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9377   -5.2326   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003726

>  <SMILES>
Cc1cccc(C(=O)N2CC3(C2)OCCC3COc2cccnc2)c1

$$$$
SWF003727
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0395   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4407   -3.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0230   -2.7231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4298   -3.6367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003727

>  <SMILES>
O=C(c1ccco1)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF003728
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2094   -1.7364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5150   -3.8734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5715   -0.5966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5117    0.4016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3463    0.9525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6173    0.8489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2865    1.9507   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5575    1.8471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3921    2.3980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1211    2.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6632    2.2944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
 27 30  1  0  0  0  0
  9 10  2  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003728

>  <SMILES>
CCCNC(=O)c1nnc2n1CC1(CCN(Cc3cc(C)cc(C)c3)CC1)COC2

$$$$
SWF003729
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003729

>  <SMILES>
COc1ccc(CN2CC(F)(F)CC3(CCNC3=O)C2)cc1

$$$$
SWF003730
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   -1.2599    2.7841   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0417    3.5356   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3434    2.7841   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0417    5.0386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6860    1.3154   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7165    3.3954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3434    5.7901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2599    5.7901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9707    0.9768   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7222    2.2785   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3434    7.2932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2599    7.2932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9764   -0.1402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1924    1.9660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0417    8.0447   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6033   -0.7515   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9821   -1.2571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7604   -2.2463   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3017   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2306   -2.5588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0802    1.5721   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8420   -3.9319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  1  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003730

>  <SMILES>
CC(=O)N1N=C(C)CC12CCC1CN(C(=O)[C@H]3CC[C@H](C)CC3)CC12

$$$$
SWF003731
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.5539   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -2.2703   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -4.5407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -4.5407   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -4.5407   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108   -1.5136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -6.0542   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -0.0187   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6090    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3279    0.3064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0847   -1.0044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  2  0  0  0  0
 15 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
 10 16  1  0  0  0  0
 13 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003731

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2cccnc2OC)C1

$$$$
SWF003732
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3112   -1.5141   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0036   -0.0187   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -4.5422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3280    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0851   -1.0047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -3.7852   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561   -4.5422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8674   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2505   -4.4010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0256   -2.2794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2637   -3.2758   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5066   -1.9646   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1225   -0.5814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2325    0.6435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003732

>  <SMILES>
CCn1cc(CN2CCC(C(=O)N(C)C)(n3cccn3)CC2)cn1

$$$$
SWF003733
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.6090    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108   -1.5136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -0.0187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -4.5407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3279    0.3064   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0847   -1.0044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -3.7839   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -4.5407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -4.5407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -6.0542   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -7.5678   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  3  0  0  0  0
 22 25  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003733

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCN(Cc2ccccc2C#N)CC1

$$$$
SWF003734
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3999   -3.6112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2344   -3.0603   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF003734

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCCn2nnc(CO)c2C1

$$$$
SWF003735
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5476   -2.9008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8447   -2.9008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4413   -6.4224   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0147   -6.8859   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2971   -8.3531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
 12 13  2  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003735

>  <SMILES>
Cc1ccccc1-c1n[nH]c2c1CCN(C(=O)CN(C)C(C)C)CC2

$$$$
SWF003736
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003736

>  <SMILES>
Cc1cccc(C(=O)N2CCc3ncnc(C4CC4)c3CC2)n1

$$$$
SWF003737
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.5539   -1.5136   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0674   -1.5135   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -2.2703   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  1  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003737

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCCN(S(=O)(=O)c2ccccc2)C1

$$$$
SWF003738
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 12 14  2  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003738

>  <SMILES>
Cn1nccc1C(=O)N1C[C@H](N2CCOCC2)[C@@H]2OCCC[C@@H]21

$$$$
SWF003739
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0670   -8.1233   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003739

>  <SMILES>
CN(C)Cc1noc2c1CC(NS(=O)(=O)c1ccccc1)CC2

$$$$
SWF003740
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -2.3965   -7.3234   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6394   -8.6347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3833   -6.1981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2553  -10.0181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.8140   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3114   -6.0569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3114   -4.5427   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.7856   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9341    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  1  0  0  0
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 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
  4  6  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003740

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2csc(C)n2)C1

$$$$
SWF003741
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.0578    1.5214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9254    3.2807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7006    2.5735   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9594    3.5395   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003741

>  <SMILES>
O=C(N1C[C@@H]2COC[C@]2(COCC2CCOCC2)C1)C1(F)CCC1

$$$$
SWF003742
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9532   -2.5460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9057   -3.9877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8442   -2.0920   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  3  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 10 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003742

>  <SMILES>
CN(C)Cc1cncc2c1CCN(C(=O)C1(C#N)CCCC1)C2

$$$$
SWF003743
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4239    1.5383   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
  9 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003743

>  <SMILES>
O=C(CC1CN(C2CCC2)Cc2cccn2C1)N1CCOCC1

$$$$
SWF003744
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7102   -0.7079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    3.1906   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1937    2.7602   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  1  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003744

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCCn2nnc(CN3CCCCC3)c2C1

$$$$
SWF003745
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003745

>  <SMILES>
O=C(c1cc[nH]c1)N1CCc2ncnc(N3CCOCC3)c2CC1

$$$$
SWF003746
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003746

>  <SMILES>
O=C(/C=C/c1cccs1)N1CCC2(CC1)CC(=O)N(CC1CC1)C2

$$$$
SWF003747
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
    7.6671    6.2769   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003747

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3ncc(C(F)(F)F)[nH]3)CC[C@H]21)NCc1ccccc1

$$$$
SWF003748
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
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  4  6  1  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003748

>  <SMILES>
c1cnc(OC2CCOC3(C2)CN(Cc2cccs2)C3)nc1

$$$$
SWF003749
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003749

>  <SMILES>
CC(C)CCC(=O)N1CC2(C1)OCCC2CCOc1cccnc1

$$$$
SWF003750
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003750

>  <SMILES>
Cc1ccoc1C(=O)N1C[C@@H]2[C@@H](CNC(=O)c3ccncc3)CO[C@@H]2C1

$$$$
SWF003751
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4962   -0.4297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1348    1.2340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -1.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2283   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3622   -3.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
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  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003751

>  <SMILES>
O=C1C[C@H]2[C@@H](CCN2Cc2ccsc2)N1Cc1cccnc1

$$$$
SWF003752
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    7.6581   -0.4984   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.3912   -1.1786   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9251    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9780   -1.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3383    0.2347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0224   -0.9367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3433   -2.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8433   -3.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1214   -2.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8545   -3.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003752

>  <SMILES>
CS(=O)(=O)N1CCOCC2(CCN(C(=O)CCc3ccc[nH]3)CC2)C1

$$$$
SWF003753
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3666    0.9748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8882    4.8577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1382    7.1660   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  9  7  1  1  0  0  0
 10  9  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003753

>  <SMILES>
Cn1cc(CN2CC[C@]3(CCC[C@@H]3C(=O)N3CC(F)(F)C3)C2)cn1

$$$$
SWF003754
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0395   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4407   -3.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8475   -4.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0285   -2.6186   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8420   -4.4457   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4298   -3.6367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003754

>  <SMILES>
O=C(c1ccncn1)N1CC2(CC(Oc3cccnc3)CS2)C1

$$$$
SWF003755
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003755

>  <SMILES>
O=C(N1CC2(CC(Oc3ccccn3)CCO2)C1)C1(F)CC1

$$$$
SWF003756
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -9.0489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -9.0489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240  -10.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  2  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003756

>  <SMILES>
Cc1ccc(CN2CCc3oc(C(=O)N4CCC(F)(F)CC4)nc3C2)cc1

$$$$
SWF003757
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7159   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080   -2.5577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2191    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0602    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7293    2.2121   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1466    1.8757   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2293    3.0782   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2511    2.8702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6360    3.9917   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003757

>  <SMILES>
COCCN1CC[C@]2(CN(C(=O)c3ncn(C)n3)C[C@H]2C)C1=O

$$$$
SWF003758
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6037    1.0382   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3368    1.7184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5149    0.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2923    1.4237   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2105   -2.8546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2077   -2.7798   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -3.7555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8513   -4.7527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9504   -4.3189   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7171   -5.7437   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2593   -5.0417   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7332   -5.9223   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  6  0  0  0
 23 25  1  6  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003758

>  <SMILES>
Cc1nc(CN2CCN(C(=O)C3[C@H]4COC[C@@H]34)Cc3cccnc32)cs1

$$$$
SWF003759
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4952  -10.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -3.7418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -4.0537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2341   -5.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003759

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(C(=O)c2ccc(F)cc2)CC1

$$$$
SWF003760
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9033    4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4890    4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003760

>  <SMILES>
CC(C)NC(=O)C1(Nc2ccccc2)CCN(C(=O)C2CCC2)CC1

$$$$
SWF003761
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5772   -0.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003761

>  <SMILES>
CCO[C@H]1CCN(C(=O)Cc2ccc(F)cn2)[C@H]1Cc1cccnc1

$$$$
SWF003762
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.0553   -0.7059   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0127   -0.5776   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7880    0.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7539    0.3883   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  8  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003762

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1C[C@@H]2CCN(C(=O)C3(F)CCC3)C[C@H]2O1

$$$$
SWF003763
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7159   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003763

>  <SMILES>
O=C1N(CC2CC2)CCC12CN(Cc1cn[nH]c1)CC(F)(F)C2

$$$$
SWF003764
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3614   -5.9205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003764

>  <SMILES>
Cc1nc(COC2CSC3(C2)CN(C(=O)CC2CC2)C3)cs1

$$$$
SWF003765
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 20 17  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003765

>  <SMILES>
CC(C)CNC(=O)c1ncn2c1CN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)CCC2

$$$$
SWF003766
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
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 21 25  2  0  0  0  0
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  6  8  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003766

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF003767
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 19  2  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  9  1  0  0  0  0
 12 14  1  0  0  0  0
 19 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003767

>  <SMILES>
O=C(N1CCOCC1)N1CCC2(CC1)C(=O)NCCN2Cc1ccccc1

$$$$
SWF003768
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.6572    3.5125   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7618    2.5179   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5527    4.5070   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6517    3.6170   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003768

>  <SMILES>
CS(=O)(=O)N[C@H]1C[C@@]2(CCN(C(=O)CC3(O)CCC3)C2)C1

$$$$
SWF003769
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2875   -4.0682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6414   -0.1055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0174   -1.9091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8609   -4.5317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4022   -5.0719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5491   -5.9989   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0904   -6.5391   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  END
>  <HTSID>
SWF003769

>  <SMILES>
CCc1ccc(C(=O)N2C[C@@H]3C(C(=O)N(C)C)=NO[C@@H]3C2)cn1

$$$$
SWF003770
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.6721   -1.2275   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4801   -5.2379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4436   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6936   -6.1196   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.9072   -5.2379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003770

>  <SMILES>
O=C(C1CCOC1)N1CCC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF003771
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.6090    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3108   -1.5136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6215   -3.7839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -0.0187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -4.5407   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3279    0.3064   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5539   -6.0542   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1754   -9.0813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4862   -8.3245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  7  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003771

>  <SMILES>
CCc1ccc(CN2CCCC(C(=O)N(C)C)(n3ccnc3)C2)cc1

$$$$
SWF003772
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  1  0  0  0  0
 12 15  1  0  0  0  0
 17 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003772

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(Cc3ccco3)CC2)c1

$$$$
SWF003773
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.3114   -9.0853   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.3282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  1  0  0  0
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 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
  7  8  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003773

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(Cc2ccccc2F)C1

$$$$
SWF003774
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
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 24 26  2  0  0  0  0
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 12 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003774

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccccn2)CC1

$$$$
SWF003775
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 16  2  0  0  0  0
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 15 18  1  0  0  0  0
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 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003775

>  <SMILES>
C=CC(=O)N1CCC(Nc2cccc(OC)c2)(C(=O)NC)CC1

$$$$
SWF003776
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.9721   -6.4508   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003776

>  <SMILES>
CO[C@H]1CCN(C(=O)c2cnccn2)[C@@H]2CN(CC3CC3)C[C@H]12

$$$$
SWF003777
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003777

>  <SMILES>
COCC1CN(Cc2ccco2)CC12CCN(CC1CCC1)CC2

$$$$
SWF003778
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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   -5.3392    0.4061   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  2  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003778

>  <SMILES>
Cn1cc(CN2CC3Cc4ncc(-c5ccccc5)n4CC3C2)cn1

$$$$
SWF003779
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   15.5885    5.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.5885    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.8875    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9904    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8875    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.1865    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   18.1865    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003779

>  <SMILES>
COCCNC(=O)CC1CCC2(CC1)CCN(C(=O)c1ccccc1)CC2

$$$$
SWF003780
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   10.8982    6.2368   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.5892    5.2858   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6111    5.0778   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2584    4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003780

>  <SMILES>
CC(C)CCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cccc(F)c2)CC1

$$$$
SWF003781
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5430    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7297   -2.7640   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
  9 10  2  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003781

>  <SMILES>
COCCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cnn(C(C)C)c2)CC1

$$$$
SWF003782
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003782

>  <SMILES>
COc1cccc(NC2(C(=O)NC3CC3)CCN(C)CC2)c1

$$$$
SWF003783
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    6.4952    4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452    5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    3.2010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF003783

>  <SMILES>
C=CCCC(=O)N1CC[C@@H]2OCCN(S(C)(=O)=O)[C@H]2C1

$$$$
SWF003784
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  6  9  1  0  0  0  0
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 19 22  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF003784

>  <SMILES>
c1ccc(OC2CCOC3(C2)CN(Cc2ccco2)C3)nc1

$$$$
SWF003785
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003785

>  <SMILES>
Cn1ccc(NC2(C(=O)N3CCCC3)CCN(c3ncccn3)CC2)n1

$$$$
SWF003786
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003786

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CCC(C(=O)N1CCOCC1)C2

$$$$
SWF003787
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  2  0  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003787

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF003788
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.8908   -3.5134   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1779   -4.6723   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1561   -4.8803   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5326   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4651   -5.8313   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393   -2.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003788

>  <SMILES>
CC(C)NC(=O)c1[nH]nc2c1CC(CNC(=O)c1cc[nH]c1)OC2

$$$$
SWF003789
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    3.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981    3.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5981    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8964    2.4343   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5048    1.6253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1044    1.4562   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0179    1.0494   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF003789

>  <SMILES>
Cc1ccc(CN2CCO[C@@H]3C[C@@H](C(=O)NCC4CC4)C[C@H]32)o1

$$$$
SWF003790
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.4319   -1.6360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 13 11  1  1  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003790

>  <SMILES>
CCN1C(=O)[C@]2(CC[C@@H]3CN(Cc4ccccc4F)C[C@@H]32)N=C1C

$$$$
SWF003791
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    3.8301    0.8660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301   -0.8660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1348    1.2340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -1.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1713   -2.5175   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5532   -2.5175   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8622   -3.4685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1223   -2.2084   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 24 28  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003791

>  <SMILES>
Cc1noc(C)c1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1cccc(C(F)(F)F)c1

$$$$
SWF003792
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3839    5.1680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749    5.7558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 20  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003792

>  <SMILES>
O=C(c1ccco1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF003793
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 27 30  1  0  0  0  0
 28 31  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <HTSID>
SWF003793

>  <SMILES>
O=S(=O)(NCC1CCC2(CCN(c3ncnc4ccsc34)CC2)CO1)c1ccccc1

$$$$
SWF003794
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.8538   -2.2480   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8538   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1628   -3.1991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2660   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5448   -3.1991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3538   -3.7868   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6728   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2715   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6024   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7715   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7934   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  2  0  0  0  0
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  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003794

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)c3cccs3)C2)C1

$$$$
SWF003795
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.5712    8.7224   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2622    7.7713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2840    7.5634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9313    7.0282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0250    6.6124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6223    6.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6441    5.8692   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3351    4.9182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0042    4.1750   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6952    3.2240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9824    4.3829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3643    2.4808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003795

>  <SMILES>
CNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2ccc(F)cc2)CC1

$$$$
SWF003796
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.2084   -5.0527   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9515   -4.3836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9501   -4.4360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0038   -3.3850   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5377   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6990   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003796

>  <SMILES>
O=C(C1CC(F)C1)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF003797
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.5527   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5308   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2000   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8910    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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  2  4  1  0  0  0  0
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  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003797

>  <SMILES>
CN(C)CCO[C@H]1CN(Cc2ccncc2)[C@@H]2CCCO[C@H]12

$$$$
SWF003798
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.1982   -2.3486   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2019   -1.2338   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7310   -2.0367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  2  0  0  0  0
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 18 20  1  0  0  0  0
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  6  9  2  0  0  0  0
 11 16  1  0  0  0  0
 14 19  1  0  0  0  0
 15 17  2  0  0  0  0
M  END
>  <HTSID>
SWF003798

>  <SMILES>
CC(C)Cn1cnc2c1C1(CCN(C)CC1)Oc1ccccc1-2

$$$$
SWF003799
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.1471    1.2990   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 13  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003799

>  <SMILES>
CN1Cc2ccccc2CC2(CCN(C(=O)CC(F)(F)F)CC2)C1=O

$$$$
SWF003800
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8255    1.1637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1564    0.4205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0823    1.8328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003800

>  <SMILES>
Cc1cccc(CN2CCCC3(CCCN3S(C)(=O)=O)C2)n1

$$$$
SWF003801
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.5527   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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M  END
>  <HTSID>
SWF003801

>  <SMILES>
CN(C)CCO[C@H]1CN(Cc2ccccn2)[C@@H]2CCCO[C@H]12

$$$$
SWF003802
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
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 11 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003802

>  <SMILES>
Cc1nnc(N2CCCC3(CN(C(=O)C4(F)CCC4)CCO3)C2)o1

$$$$
SWF003803
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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  9 14  1  1  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003803

>  <SMILES>
O=C(c1cc[nH]c1)N1CC[C@@H]2OCCN(C(=O)c3cnccn3)[C@H]2C1

$$$$
SWF003804
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003804

>  <SMILES>
Cc1csc(C(=O)N2C[C@@H]3CN(C(=O)c4cscn4)CCO[C@@H]3C2)c1

$$$$
SWF003805
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003805

>  <SMILES>
O=C(NCCO)c1ncn2c1CCC(C(=O)NC1CCC1)C2

$$$$
SWF003806
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  2  0  0  0  0
  8  9  2  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003806

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1ncc(C(F)(F)F)[nH]1

$$$$
SWF003807
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003807

>  <SMILES>
CNC(=O)C1CN(Cc2ccc(-n3ccnc3)cc2)CC12CCOCC2

$$$$
SWF003808
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003808

>  <SMILES>
CNC(=O)[C@H]1CCC[C@]12CCN(C(=O)c1cncc(F)c1)C2

$$$$
SWF003809
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7696    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8879    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003809

>  <SMILES>
COCCNC(=O)[C@@H]1CN(Cc2ccccc2)C[C@H]2OCC[C@H]21

$$$$
SWF003810
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5196    2.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5817    3.2040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9820    3.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5921    5.1119   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0839    5.2687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7105    6.3254   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3206    7.6957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0654    9.9660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5736    9.8092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003810

>  <SMILES>
COCCNC1CSC2(C1)CN(C(=O)c1ccc(OC)nc1)C2

$$$$
SWF003811
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3598   -1.4657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9891   -0.6886   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5660   -1.2885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7525   -3.1156   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7470   -3.0111   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003811

>  <SMILES>
c1cc(CN2CCC3(C2)CN(CC2CCOCC2)C3)cs1

$$$$
SWF003812
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.2942   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5442    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1002   -8.9489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003812

>  <SMILES>
COCC(=O)N1CC(F)(F)CC2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF003813
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7572    5.1786   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6553    3.6515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3838    6.2353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003813

>  <SMILES>
COc1ncc(CN2CCOC3(COC(C(=O)NCc4ccccc4)C3)C2)cc1C

$$$$
SWF003814
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.9405   -1.8647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7837   -0.3729   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8245    0.6771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7495    1.1181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0075    1.9351   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2047    4.4060   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5165    5.8732   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7781    3.9425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4018    6.8769   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6634    4.9462   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9752    6.4134   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003814

>  <SMILES>
CCOCC1CCS(=O)(=O)C12CN(Cc1cccnc1)C2

$$$$
SWF003815
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6589   -0.3217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -0.3272   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6808   -0.5296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -0.8272   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2275    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2275   -0.3272   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3615   -1.8272   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0936    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003815

>  <SMILES>
Cc1cc(C(=O)N2CC[C@]3(C[C@@H](OCC4CC4)CO3)C2)cc(C)n1

$$$$
SWF003816
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.2955   -3.0240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4138   -4.2376   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9221   -4.0808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0239   -5.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0404   -5.2943   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2739   -6.9069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4912   -5.9197   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2776   -8.0216   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6480   -7.4115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003816

>  <SMILES>
O=C(NCc1ccncc1)C1=NOC2(CCCN(C(=O)c3cc[nH]c3)C2)C1

$$$$
SWF003817
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -6.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026   -7.4087   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003817

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3ccco3)C2)CN1CC1CC1

$$$$
SWF003818
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9462   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8792  -11.0963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8628  -10.7827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2527  -12.1530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10  9  1  1  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003818

>  <SMILES>
CCCNC(=O)C1=NOC2(CCCN(Cc3ccccc3)C2)C1

$$$$
SWF003819
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.8726    0.1261   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.7158   -1.3657   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0861   -0.7556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7543    1.3396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4369    1.4486   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2151   -0.6611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2461    1.1828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1442    2.7099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1278    2.3963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0259    3.9235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5177    3.7667   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 24  2  0  0  0  0
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  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003819

>  <SMILES>
O=S(=O)(c1ccccc1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF003820
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.3274   -3.9465   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.3493   -3.7386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8493   -4.6046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9426   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5184   -5.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5413   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9590   -2.5115   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 26 27  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003820

>  <SMILES>
O=C(NCc1ccc(F)cc1)C1CC2(CO1)CN(Cc1nccs1)CCO2

$$$$
SWF003821
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0078    4.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5807    4.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5442    6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0442    6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003821

>  <SMILES>
COCc1ccc(C(=O)N2C[C@@H]3CN(C)CCO[C@@H]3C2)cc1

$$$$
SWF003822
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.1152   -0.2873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4461   -1.0305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7551   -1.9815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 12 13  2  0  0  0  0
 16 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003822

>  <SMILES>
CC1c2nnc(COc3cccnc3)n2CCN1C(=O)c1ccco1

$$$$
SWF003823
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    1.3469    8.3066   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0161    7.5634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7070    6.6124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7363    4.1750   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003823

>  <SMILES>
CCCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cccc(F)c2)CC1

$$$$
SWF003824
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.1617   -0.1652   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3185   -1.6570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4781    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0767    2.1316   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7606   -2.5306   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003824

>  <SMILES>
CN1CC2(CCN(Cc3cccs3)C2)Oc2ccccc2S1(=O)=O

$$$$
SWF003825
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9282   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003825

>  <SMILES>
O=C(N1CCC2(CCCN(Cc3ccncc3)C2=O)CC1)C1(F)CC1

$$$$
SWF003826
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9684   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2803   -0.1727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4639   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0740   -1.2275   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3456   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5658   -1.0707   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8373   -3.6546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4474   -2.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003826

>  <SMILES>
Cc1csc(C(=O)N2CCC3(CC2)CCN(c2cccnc2)C3=O)c1

$$$$
SWF003827
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -1.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452   -2.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9952   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  1  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003827

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(S(=O)(=O)c2ccccc2)C1

$$$$
SWF003828
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003828

>  <SMILES>
CC(C)NC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccc2)CC1

$$$$
SWF003829
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2500    0.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7990    5.1073   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010    5.1073   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7010    5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9428    6.5631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8409    7.7767   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9556    8.7804   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003829

>  <SMILES>
CC1(C)CC1C(=O)N1C[C@@H]2OCCN(CC3CCCC3)[C@H]2C1

$$$$
SWF003830
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003830

>  <SMILES>
Cc1cccnc1C(=O)N1C[C@@H]2OCCN(CC3CCCC3)[C@H]2C1

$$$$
SWF003831
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 20 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003831

>  <SMILES>
O=C(NC1CCCCC1)c1nnc2n1CC1(CCN(Cc3cccs3)CC1)COC2

$$$$
SWF003832
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003832

>  <SMILES>
CN(C)CC1CCC2(COCCN(Cc3ccncc3)C2)O1

$$$$
SWF003833
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    9.4244   -1.5703   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10  9  1  1  0  0  0
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 11 14  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003833

>  <SMILES>
O=C1C[C@@H]2[C@H](CCN2Cc2ccc(F)cc2)N1CCN1CCCC1

$$$$
SWF003834
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  2  0  0  0  0
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  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003834

>  <SMILES>
Cc1cccc(CN2CCC3(CC2)C(=O)N(C)CCN3C)n1

$$$$
SWF003835
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  7  1  1  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003835

>  <SMILES>
c1cncc(CO[C@@H]2C[C@H]3CN(Cc4cccnc4)CCN3C2)c1

$$$$
SWF003836
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3040   -0.3752   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.2634   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003836

>  <SMILES>
O=C1[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]2CN1c1cccnc1

$$$$
SWF003837
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -3.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -4.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -3.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7725   -5.3385   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -5.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
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  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003837

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CCN(c2cccnc2)C3=O)n1

$$$$
SWF003838
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.3121    0.5305   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1792   -5.2521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7615   -4.5476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
  9 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003838

>  <SMILES>
CNC(=O)CC1CC2(CCN(C(C)=O)CC2)c2cc(F)ccc21

$$$$
SWF003839
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003839

>  <SMILES>
Cc1nc(CN2CC[C@@H]3CN(Cc4cncn4C)C[C@@H]3CC2)cs1

$$$$
SWF003840
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003840

>  <SMILES>
CCN(C)C(=O)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF003841
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003841

>  <SMILES>
CN(C)C1COC2(CCN(C(=O)C3(C)CC=CCC3)CC2)C1

$$$$
SWF003842
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    0.0179    7.0848   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003842

>  <SMILES>
COCC1CN(C)CC12CCN(Cc1ccc(C)s1)CC2

$$$$
SWF003843
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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  1  4  1  0  0  0  0
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M  END
>  <HTSID>
SWF003843

>  <SMILES>
CN(C)c1nccc([C@@H]2C[C@@H]3CCN(S(=O)(=O)c4cn(C)cn4)C[C@H]3O2)n1

$$$$
SWF003844
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 16 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003844

>  <SMILES>
CC(C)N1[C@@H](C(=O)NCCN(C)C)C[C@H]2CN(Cc3ccccn3)C[C@H]21

$$$$
SWF003845
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.3048    6.9145   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003845

>  <SMILES>
COCC1CN(C)CC12CCN(Cc1ccc(OC)cc1)CC2

$$$$
SWF003846
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4393   -1.5665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2258   -3.6684   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5961   -3.0583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4932   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -1.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -0.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -1.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0913   -0.8083   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003846

>  <SMILES>
Cc1nc(CN2CC3CN(Cc4ccc(F)cc4)CC3S2(=O)=O)cs1

$$$$
SWF003847
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003847

>  <SMILES>
Cc1ccc(C(=O)N2CC(F)(F)CC3(CCNC3=O)C2)cn1

$$$$
SWF003848
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003848

>  <SMILES>
Cc1ncnc(C(=O)N2CCc3ncnc(-c4cncnc4)c3C2)c1C

$$$$
SWF003849
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.3240   -4.0808   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5921    2.7945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
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 18 22  1  0  0  0  0
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 21 24  1  0  0  0  0
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 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003849

>  <SMILES>
Cc1cccc(C(=O)N2CC(C(=O)N3CCCC3)C3(CCOCC3)C2)c1

$$$$
SWF003850
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003850

>  <SMILES>
Cc1nc(C(=O)N2CC(F)(F)CC3(CCN(C)C3=O)C2)c[nH]1

$$$$
SWF003851
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8528    1.2364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5472    3.3734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0056    1.7493   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7804    0.2002   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003851

>  <SMILES>
CC(C)NC(=O)c1ncn2c1CN(C(=O)CC1(O)CCC1)CCC2

$$$$
SWF003852
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -2.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  7  9  1  0  0  0  0
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  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003852

>  <SMILES>
CC(C)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF003853
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
   15.7567    7.1258   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   14.2895    6.8139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2858    7.9286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8185    7.6168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3587    5.0755   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3550    6.1902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.4243    4.4517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9570    4.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4280    3.3370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 21 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF003853

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CC1(CC2)CCN(Cc2ccc(F)cc2)CC1

$$$$
SWF003854
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  7  5  1  6  0  0  0
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  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003854

>  <SMILES>
CN1CCC2(CN(C(=O)c3cnccn3)CC(F)(F)C2)C1=O

$$$$
SWF003855
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    4.2709   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003855

>  <SMILES>
CCCC(=O)N1CCn2cc(C(=O)NCCOC)nc2C1C

$$$$
SWF003856
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.5755   -4.0929   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3236   -3.4293   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4890   -2.8784   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3218   -3.4891   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5947   -3.3257   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5488   -1.8802   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6754   -1.3932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4742   -1.5010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 15 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003856

>  <SMILES>
O=C(Nc1ccccc1)c1cnn2c1CN(C(=O)C1(F)CC1)CCC2

$$$$
SWF003857
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2570   -3.4182   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471   -5.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2654   -6.5218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  5  1  6  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003857

>  <SMILES>
COc1ncccc1C(=O)N1CC(F)(F)CC2(CCN(C)C2=O)C1

$$$$
SWF003858
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.7364    1.6479   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3657    2.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2612    3.4195   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522    2.8317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9480    1.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003858

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1CC12CCN(C(=O)C1(F)CC1)C2

$$$$
SWF003859
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.8255   -2.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  7  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003859

>  <SMILES>
CCOCC1C(=O)N(CC)CC12CCN(C(=O)C1CC(O)C1)CC2

$$$$
SWF003860
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    8.4891    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0256    3.9790   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0219    2.8643   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9563    2.8643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7026    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8834    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7063    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4411   -1.4802   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7530   -2.9474   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
M  END
>  <HTSID>
SWF003860

>  <SMILES>
CCOCC(=O)N1CC2(C1)C(COCC)CCS2(=O)=O

$$$$
SWF003861
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.5772    4.5284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5283    4.2194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7362    3.2413   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2715    4.8885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077    3.0042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9451    2.6295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9302    1.6296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003861

>  <SMILES>
COCc1nnc2n1CCN(C(=O)c1ccc3ccccc3n1)C(C)C2

$$$$
SWF003862
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003862

>  <SMILES>
COc1ccc(CN2CCOC3(COC(C(=O)NCc4ccccc4)C3)C2)cc1

$$$$
SWF003863
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.2751    1.8251   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7614    0.4868   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF003863

>  <SMILES>
CCCC(=O)N1CC2(C1)OCCC2COc1ncccc1F

$$$$
SWF003864
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003864

>  <SMILES>
CCn1cc(CN2CC[C@H]3[C@@H]2CC(=O)N3Cc2ccccc2)cn1

$$$$
SWF003865
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF003865

>  <SMILES>
O=C(NC1CCS(=O)(=O)C1)C1=NOC2(CCCN(Cc3ccccc3)C2)C1

$$$$
SWF003866
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003866

>  <SMILES>
Cc1nc(CN2CCCC3(CCCN(C(=O)c4cncnc4)C3)C2)cs1

$$$$
SWF003867
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.0088   -5.2529   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003867

>  <SMILES>
COCCC1CCOC12CCN(S(=O)(=O)c1ccccc1)CC2

$$$$
SWF003868
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.2350    4.0963   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003868

>  <SMILES>
O=C(CC1CC1)N1CC2(C1)OCCC2COc1ncccc1F

$$$$
SWF003869
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003869

>  <SMILES>
CN1C(=O)C2(CCN(Cc3cccnc3)CC2)c2ccccc21

$$$$
SWF003870
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003870

>  <SMILES>
O=C(C1CCC1)N1CC2(C1)OCCC2COc1ncccc1F

$$$$
SWF003871
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003871

>  <SMILES>
O=C(CC1CC2(CCN(Cc3cn[nH]c3)CC2)Oc2ccccc21)NC1CC1

$$$$
SWF003872
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 12 11  1  1  0  0  0
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 13 16  1  0  0  0  0
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  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003872

>  <SMILES>
O=C(c1cc(F)ncc1F)N1CC[C@H]2CN(Cc3cccnc3)C[C@H]21

$$$$
SWF003873
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003873

>  <SMILES>
O=C(Cc1cccc(F)c1)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF003874
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 11  1  0  0  0  0
 10 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003874

>  <SMILES>
CC1CC(C(=O)N2CCCC3(CC(Nc4cnccn4)CO3)C2)C1

$$$$
SWF003875
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003875

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H](OCC3CC3)[C@H]3OCCC[C@H]32)cn1

$$$$
SWF003876
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.9462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003876

>  <SMILES>
Cc1ccccc1CC(=O)N1CC(F)(F)CC2(CCN(C)C2=O)C1

$$$$
SWF003877
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF003877

>  <SMILES>
CCn1cc(CN2CC[C@H]3[C@@H]2CC(=O)N3Cc2ccc(F)cc2)cn1

$$$$
SWF003878
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003878

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF003879
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 14 16  1  0  0  0  0
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 16 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003879

>  <SMILES>
CCn1cc(CN2CC(C(=O)NC)C3(CCOCC3)C2)cn1

$$$$
SWF003880
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 15  1  0  0  0  0
 16 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003880

>  <SMILES>
CN(C)C(=O)C1(Nc2ccnn2C)CCN(Cc2ccccc2)CC1

$$$$
SWF003881
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  1  0  0  0  0
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 17 21  2  0  0  0  0
 19 22  3  0  0  0  0
 20 23  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003881

>  <SMILES>
CN1CCC2(CN(Cc3ccccc3C#N)CC(F)(F)C2)C1=O

$$$$
SWF003882
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003882

>  <SMILES>
COc1cc(CN2Cc3ccnn3CCC2CO)cc(OC)c1

$$$$
SWF003883
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003883

>  <SMILES>
Cc1cc(C(=O)N2CCCC3(CCCN(CC(=O)N4CCCC4)C3)C2)n(C)n1

$$$$
SWF003884
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003884

>  <SMILES>
Cc1csc(C(=O)N2CCCC3(CCCN(CC4CC4)C3)C2)c1

$$$$
SWF003885
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 21  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003885

>  <SMILES>
O=C(CCn1cccn1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF003886
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    9.0933   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003886

>  <SMILES>
CN1CCC12CCCN(C(=O)CCc1ccc(Cl)cc1)C2

$$$$
SWF003887
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
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 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003887

>  <SMILES>
O=C(C1=COCC1)N1C[C@H]2CCN(c3ncccn3)CC[C@H]2C1

$$$$
SWF003888
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7243   -2.6360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8781   -5.7350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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  8 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003888

>  <SMILES>
CN1CC(COc2cccnc2)CC12CN(c1ncccn1)C2

$$$$
SWF003889
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 15  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003889

>  <SMILES>
Cn1cnc(C(=O)N2CCCC3(CCCN(c4ncccn4)C3)C2)c1

$$$$
SWF003890
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9510    5.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
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  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003890

>  <SMILES>
Cc1cccc(CN2CCCC3(CCCN(C(=O)c4cn(C)nc4C)C3)C2)n1

$$$$
SWF003891
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003891

>  <SMILES>
O=C(c1cccc(Cl)n1)N1C[C@@H]2OCCN(CC3CC3)[C@@H]2C1

$$$$
SWF003892
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.9392    2.4955   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  1  0  0  0
  6  9  1  0  0  0  0
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  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 19 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003892

>  <SMILES>
COc1ccc(C(=O)N2C[C@H]3CN(CC(C)C)C(=O)[C@H]3C2)c(C)c1

$$$$
SWF003893
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003893

>  <SMILES>
Cc1csc(C(=O)N2CCC3(CC2)CC(N(C)C)CCO3)c1

$$$$
SWF003894
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.0333   -3.3107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0333   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003894

>  <SMILES>
Cc1cccc(C(=O)N2CC3(CCC(CN4CCCCC4=O)CO3)C2)c1

$$$$
SWF003895
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.1104    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8046    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5477    0.5248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0125    2.1720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  6  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003895

>  <SMILES>
CO[C@H]1CCN(C(=O)C2(C)CC=CCC2)[C@H]1Cc1cnn(C)c1

$$$$
SWF003896
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
   -0.3859    0.3183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0209    1.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0154    1.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5669    2.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6845    0.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5154    2.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2579    2.9920   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  2  0  0  0  0
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 21 26  1  0  0  0  0
 24 27  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003896

>  <SMILES>
CCCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccco1)C2

$$$$
SWF003897
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.4200   -3.9159   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003897

>  <SMILES>
O=C(N1CC2(C1)OCCC2COc1cccnc1)C1(F)CC1

$$$$
SWF003898
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971    4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003898

>  <SMILES>
O=C(C1CC(O)C1)N1CCC2(CCC(=O)N2Cc2cccc(F)c2)CC1

$$$$
SWF003899
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  8  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003899

>  <SMILES>
CCS(=O)(=O)NCCC1CN(Cc2ccccc2)Cc2ccnn21

$$$$
SWF003900
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9538    3.3479   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2628    4.2989   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5583    5.8812   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2809    5.7002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4719    6.2880   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1944    6.1069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0035    5.5191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2990    7.1014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9170    5.9259   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2125    7.5082   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215    6.9204   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 11 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003900

>  <SMILES>
O=C(c1ccccn1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)C1

$$$$
SWF003901
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568    3.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1980    1.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0827    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5827   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 16 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 15 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003901

>  <SMILES>
COc1cccc2cc(C(=O)N3CCCC4(CCN4C)C3)oc12

$$$$
SWF003902
Actelion Java MolfileCreator 1.0

 33 37  0  0  1  0  0  0  0  0999 V2000
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0459   -4.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4526   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8648   -5.9566   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4472   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2716   -6.8701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8539   -6.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4080    1.1522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9903    1.8567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  1  0  0  0
  7 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  1  0  0  0  0
 17 23  1  0  0  0  0
 18 24  1  0  0  0  0
 19 25  1  0  0  0  0
 20 26  2  0  0  0  0
 23 27  1  0  0  0  0
 23 28  1  0  0  0  0
 25 29  2  0  0  0  0
 25 30  1  0  0  0  0
 29 31  1  0  0  0  0
 30 32  2  0  0  0  0
 31 33  2  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 26  1  0  0  0  0
 22 24  2  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF003902

>  <SMILES>
CC(C)n1nccc1[C@@H]1CN(Cc2cccnc2)C[C@]12CCCN(Cc1ccccn1)C2=O

$$$$
SWF003903
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5925    4.2980   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0346    5.7314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6736    5.9832   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1458    8.4791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0810    9.6519   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5330   11.0482   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
  9 12  1  0  0  0  0
 17 18  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003903

>  <SMILES>
C=CCN1CCOC2CN(C(=O)CCc3ccc[nH]3)CCC2C1

$$$$
SWF003904
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2522   -3.6979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -2.5985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5421   -5.1696   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6212   -3.7987   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8735   -5.8606   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2438   -5.2505   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0929   -3.5088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5777   -2.0893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0494   -1.7995   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5908   -0.9597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5342   -0.3800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0756    0.4597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5473    0.7496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003904

>  <SMILES>
O=C1CC2(COCCN(Cc3ccccc3)C2)CN1Cc1ccccc1

$$$$
SWF003905
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -2.8944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1472   -2.8944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6472   -0.2963   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6472   -2.0283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6472   -0.2963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  2  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003905

>  <SMILES>
COc1ncnc2c1CCN(C(=O)c1ccnc(F)c1)CC2

$$$$
SWF003906
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    7.1375    4.0435   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6375    4.9095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4684    3.3004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6594    4.7016   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0443    5.8231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    3.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3569    1.8320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003906

>  <SMILES>
CCC(C)N1CC2(CCCN(Cc3csc(C)n3)C2)C1=O

$$$$
SWF003907
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    9.7664   -0.3611   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8154   -0.6701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0722   -0.0010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6075   -1.6483   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1469   -0.3802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3527    0.9589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6939   -2.0550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2766   -2.3914   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2735    0.1068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7770    1.7766   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7984   -3.0495   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7766   -3.2574   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097    1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788    1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788    2.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007    2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003907

>  <SMILES>
CC(=O)Nc1ccc(-c2cnc3n2CCN(C(=O)C2CCOC2)CC3)cc1

$$$$
SWF003908
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003908

>  <SMILES>
CCN1CCC2(CCN(C(=O)c3ccccc3)CC2)CC1=O

$$$$
SWF003909
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.9020   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9341    3.9019   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4693    5.5492   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7751    5.1890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5672    6.1672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0319    4.5199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6161    6.4762   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0809    4.8289   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8730    5.8071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003909

>  <SMILES>
CC(C)CN1C[C@H]2C(=O)NC3(CCN(C(=O)c4ccccc4)CC3)[C@H]2C1

$$$$
SWF003910
Actelion Java MolfileCreator 1.0

 23 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0570    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1750    1.9511   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6750    3.4899   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8660    4.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6750    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2628    4.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2573    4.1944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8561    5.2125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8451    5.0034   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4439    6.0215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4384    5.9169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003910

>  <SMILES>
O=C(C1CC1)N1CCC2(CCn3c(-c4cccnc4)cnc32)C1

$$$$
SWF003911
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    7.4060   -6.6989   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9039   -7.6362   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5422   -4.8882   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2922   -6.1873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7082   -9.1233   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8982  -10.0365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4798   -7.9753   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.2840   -9.4625   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4740  -10.3756   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 20 23  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003911

>  <SMILES>
COc1ccc(-c2ccc3c(c2)S(=O)(=O)N(C)CC2(CCN(C)CC2)CO3)cc1

$$$$
SWF003912
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1715    1.7865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452    7.2990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    7.2990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 17 20  2  0  0  0  0
 21 17  1  1  0  0  0
 18 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  6  0  0  0
 24 26  1  6  0  0  0
 25 27  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 19 22  1  0  0  0  0
 23 24  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003912

>  <SMILES>
O=C(NCc1ccccn1)[C@@H]1CN(C(=O)[C@H]2[C@@H]3COC[C@@H]32)C[C@H]2OCC[C@H]21

$$$$
SWF003913
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2382   -4.7455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003913

>  <SMILES>
O=C1CC(c2cccnc2)C2(CCN(C(=O)c3cc[nH]c3)CC2)N1

$$$$
SWF003914
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2500    0.5490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7990    5.1073   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010    5.1073   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7010    5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510    6.4064   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4510    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9510    6.4064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9510    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7010    5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003914

>  <SMILES>
CC1(C)CC1C(=O)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF003915
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.2592   -7.5661   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7013   -6.1328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1637   -5.7990   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6810   -5.0332   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1839   -6.8986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6058   -4.3656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1232   -3.5998   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7418   -8.3319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6463   -6.5648   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7621   -9.4315   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6666   -7.6644   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0688   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4860   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2245   -9.0977   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8188   -1.7435   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2708   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8374    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8658   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003915

>  <SMILES>
Cc1ccc(C(=O)N2CCOCC3(C2)CN(c2cccnc2)C(=O)CO3)o1

$$$$
SWF003916
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7810    1.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7810    2.8090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1932    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    5.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003916

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1CN(Cc2cn[nH]c2)C[C@H]2OCC[C@H]21

$$$$
SWF003917
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6583   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -2.8944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1472   -2.8944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6472   -2.0283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6472   -0.2963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1472    0.5697   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6472   -0.2963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6472    1.4358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1472    0.5697   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6472    1.4358   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 14 15  2  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003917

>  <SMILES>
Cc1nc(C(=O)N2CCc3ncnc(-c4ccncc4)c3CC2)cs1

$$$$
SWF003918
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7938   -3.3010   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4848   -2.3499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9848   -3.8888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4848   -2.3499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1758   -3.3010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1337    0.8862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003918

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(C(=O)C1CCOC1)C2

$$$$
SWF003919
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.6943    3.2412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1603    4.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1603    4.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003919

>  <SMILES>
CNC(=O)NCC1CCC2(CCN(C(=O)C3(F)CC3)CC2)CO1

$$$$
SWF003920
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -2.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -2.9067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007   -1.5055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -2.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788   -1.2976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF003920

>  <SMILES>
O=C(c1ccco1)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF003921
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6392   -3.3205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0404   -4.3385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0514   -4.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4526   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2379   -2.3024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4581   -5.0430   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  1  0  0  0
 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
  9 11  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003921

>  <SMILES>
COc1cnccc1C(=O)N1C[C@@H](N(C)C)[C@H]2OCCC[C@H]21

$$$$
SWF003922
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.0713    2.0341   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    3.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  1  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003922

>  <SMILES>
CC(C)NC(=O)[C@@H]1CCO[C@@H]2CCN(C(=O)C3(F)CC3)C[C@@H]21

$$$$
SWF003923
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3202   -4.0536   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6192   -3.3036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3202    0.0444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8202    0.0444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3202    0.0444   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0702    1.3435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5702    1.3435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  2  0  0  0  0
 10 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  2  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF003923

>  <SMILES>
CC1c2nc(C(=O)NCc3ccco3)cn2CCN1S(=O)(=O)c1cccnc1

$$$$
SWF003924
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
    0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3955   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2007    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1872   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2737   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0657   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8089   -4.7510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6010   -5.7291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7599   -4.4420   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3441   -6.3982   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5031   -5.1111   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2952   -6.0892   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
 10 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 14 19  1  1  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 11 16  1  0  0  0  0
 12 14  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003924

>  <SMILES>
O=C(N[C@@H]1c2ccccc2[C@@H]2CN(Cc3ccncc3)C[C@H]12)c1ccncc1

$$$$
SWF003925
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9721   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0049   -5.0408   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4639   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3789   -5.5454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0086   -6.1555   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6967   -7.6228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8114   -8.6265   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2380   -8.1629   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4995  -10.0937   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  1  0  0  0
 19 22  2  0  0  0  0
 20 23  1  1  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003925

>  <SMILES>
CC(C)CN1C[C@H]2C(=O)NC3(CCN(C(=O)Cc4ccc(F)cc4)CC3)[C@H]2C1

$$$$
SWF003926
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7572    5.1786   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6553    3.6515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8755    6.3921   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7737    4.8650   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3838    6.2353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7181    4.7082   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3282    3.3379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8200    3.1811   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4466    2.1244   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4301    1.8108   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0567    0.7540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5484    0.5972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1585   -0.7731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2769   -1.9866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003926

>  <SMILES>
COc1ccc(CN2CCOC3(COC(C(=O)NCc4ccc(C)cc4)C3)C2)cc1

$$$$
SWF003927
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    9.5571   -5.7637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.0243   -6.0756   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4003   -4.2719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7743   -4.7765   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.6344   -7.4459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7706   -3.6618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0825   -2.1946   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5091   -1.7311   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9678   -1.1909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2797    0.2763   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5412   -1.6544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1649    1.2800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4265   -0.6507   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7383    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8951    2.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5248    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2130    4.3856   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 17 20  2  0  0  0  0
 18 21  1  1  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003927

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)NC(=O)[C@@H]2CN(CC(C)C)C[C@@H]23)cs1

$$$$
SWF003928
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    5.9020   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.5443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0930    2.6147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988    2.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8851    3.5929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1909    3.2327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9341    3.9019   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7261    4.8800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4693    5.5492   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7751    5.1890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5672    6.1672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0319    4.5199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6161    6.4762   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0809    4.8289   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8730    5.8071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0781    6.1161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003928

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)NC(=O)[C@@H]2CN(CC(C)C)C[C@@H]23)cc1

$$$$
SWF003929
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.5720    3.0072   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4396    4.7664   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2148    4.0593   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4736    5.0253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  8  1  0  0  0  0
 14 12  1  6  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003929

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@H]2CCN(C(=O)C3(F)CCC3)C[C@@H]2O1

$$$$
SWF003930
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980    2.2412   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909    3.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568    3.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1980    1.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 14 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 15  1  0  0  0  0
 13 18  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003930

>  <SMILES>
COc1ccc(OC)c(C(=O)N2CCCC3(CCN3C)C2)c1

$$$$
SWF003931
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   10.1004   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3139   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.5538   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4519   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7740    1.7996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4005    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8640    4.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9005    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6505    5.1646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4370    4.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003931

>  <SMILES>
COCCN1CCC2(CN(C(=O)C3=CCCC3)CC(F)(F)C2)C1=O

$$$$
SWF003932
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097    2.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007    3.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788    2.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788    3.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6386   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003932

>  <SMILES>
Cc1noc(C)c1CN1CCCC2(C1)CN(C(=O)C1CCOC1)CCO2

$$$$
SWF003933
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.1792    1.4453   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357    2.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368    2.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2148    4.0500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7874    1.4500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7874    4.0500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2763    2.9885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2148    5.5511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5148    4.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2885    1.4500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2885    4.0500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7262    3.3770   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9055    1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9000   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0391    2.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7385    1.0614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7877    2.3156   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9492    0.4771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3500   -0.3885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6000   -0.7506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3991    0.8656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6000   -2.2517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4606   -0.1958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9000   -3.0022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3000   -3.0022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  2  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  6  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 14 19  1  0  0  0  0
 14 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  8  9  1  0  0  0  0
 11 15  1  0  0  0  0
 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003933

>  <SMILES>
Cc1ccc(C2(C(=O)N3CCCC4(CCN4CC(C)C)C3)CC2)cc1

$$$$
SWF003934
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.7629    0.9076   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1752    0.0986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1806    0.2032   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5819   -0.8149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5928   -0.6059   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7739    1.1167   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0819   -1.6809   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5600   -1.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7510   -2.4241   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6646   -2.0174   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF003934

>  <SMILES>
CC(C)CNC(=O)C1CC2CN(C(=O)c3cc[nH]n3)CC1O2

$$$$
SWF003935
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4590    1.6756   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3821   -3.6245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF003935

>  <SMILES>
Cc1cc(F)c(F)cc1C(=O)N1Cc2ccnn2CCC1CO

$$$$
SWF003936
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.0134   -8.0240   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8224   -8.6118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6314   -8.0240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8224   -9.6118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9047   -6.3685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5034   -5.3504   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0034   -4.4844   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5253   -5.1425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003936

>  <SMILES>
COCCNC(=O)c1nnc2n1CCC1(CC2)CCN(C(=O)c2csc(C)n2)C1

$$$$
SWF003937
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  6  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003937

>  <SMILES>
CC1(C(=O)N2CCc3ncnc(-c4ccncc4)c3C2)CC=CCC1

$$$$
SWF003938
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    7.3223   -2.8781   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.2733   -2.5691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2733   -1.5691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0823   -3.1569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3223   -1.2601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9778   -4.1514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9959   -2.7501   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0132   -0.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7868   -4.7392   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8049   -3.3379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6010    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7004   -4.3324   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5094   -4.9202   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4229   -4.5135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003938

>  <SMILES>
COc1ccc(-c2nc(-c3noc4ccc(C(=O)NCCO)cc34)cs2)cc1

$$$$
SWF003939
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -1.1376    2.8025   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3455    3.7807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2636    3.6115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4795    4.2807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    0.9659   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3569    1.8320   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3750    5.2752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF003939

>  <SMILES>
Cc1csc(C(=O)N2CCCC3(CCN3C(=O)C(C)C)C2)c1

$$$$
SWF003940
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    8.5442   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2942   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1683   -0.2454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6600   -0.4022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.5052    2.2379   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.9234   -0.4022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2917    3.1196   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6516    2.7015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  6  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 20 25  1  0  0  0  0
 21 26  2  0  0  0  0
 21 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 22 24  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF003940

>  <SMILES>
Cc1noc(C)c1CN1CCC2(C1)CN(C(=O)CCc1cncnc1)CCC2(F)F

$$$$
SWF003941
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5886    0.7497   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4620    1.2367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8341   -0.0033   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8301    0.0864   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.4700   -1.4911   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003941

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCOCC2(CC(Cn3ccnc3)CO2)C1

$$$$
SWF003942
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.9211   -2.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5902   -1.2601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5683   -1.4680   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812   -0.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9751   -2.3815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6386   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF003942

>  <SMILES>
Cc1ncoc1C(=O)NC1CCc2onc(C(=O)N3CCCC3)c2C1

$$$$
SWF003943
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    3.1309   -3.7888   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1650   -4.0477   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0969   -3.5300   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8721   -2.8229   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3898   -4.7548   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2984   -3.2038   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3849   -3.6105   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003943

>  <SMILES>
CS(=O)(=O)N1C[C@H]2CN(C(=O)c3cc(C4CC4)on3)[C@H]2C1

$$$$
SWF003944
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9304   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.2294   -1.8107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003944

>  <SMILES>
c1ccc(CN2CC3(CCC(CN4CCOCC4)CO3)C2)nc1

$$$$
SWF003945
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7128    7.7537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1027    9.1240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6109    8.9672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6435    6.0152   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1837    8.5565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1108    5.7034   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    8.2447   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003945

>  <SMILES>
O=C(C1CC1)N1CCC2(CCc3ncc(-c4ccncc4)n3C2)CC1

$$$$
SWF003946
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0622   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0622   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF003946

>  <SMILES>
CNC(=O)NCC1CCC2(CCN(C(=O)CN(C)C(C)C)CC2)CO1

$$$$
SWF003947
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003947

>  <SMILES>
CN(C)CC1CCC2(CN(C(=O)CCc3ccccc3Cl)C2)OC1

$$$$
SWF003948
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.0426    5.7715   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5790    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1118    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6483    2.6065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9711   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8528    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.3446    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9547   -1.3361   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2262    1.2478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8259    1.7853   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   15.5965    1.8579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3830    2.7395   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 23 27  1  0  0  0  0
  6  7  1  0  0  0  0
  9 12  1  0  0  0  0
 15 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003948

>  <SMILES>
CCNC(=O)CC1CC2(CCN(C(=O)C3(F)CC3)CC2)c2cc(F)ccc21

$$$$
SWF003949
Actelion Java MolfileCreator 1.0

 23 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003949

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1CC2(CC(OCC3CC3)CS2)C1

$$$$
SWF003950
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
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  9 11  1  0  0  0  0
 17 20  1  0  0  0  0
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 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003950

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)COc3ccccc3)CC2)Oc2ccccc21

$$$$
SWF003951
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003951

>  <SMILES>
CC1N(CCN(C)C)C(=O)COC12CCN(Cc1ccccn1)CC2

$$$$
SWF003952
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003952

>  <SMILES>
O=C(CN1CCC2(CC1)CC(N1CCOCC1)CO2)N1CCCC1

$$$$
SWF003953
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <HTSID>
SWF003953

>  <SMILES>
Cc1cc(C(=O)N2CCCC3(CCCN(Cc4csc(C)n4)C3)C2)n(C)n1

$$$$
SWF003954
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003954

>  <SMILES>
c1cc(CN2CCCn3c(nnc3Cn3cnnc3)C2)ccn1

$$$$
SWF003955
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9863   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0333   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0333   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -8.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003955

>  <SMILES>
CS(=O)(=O)NCC1CCC2(CN(Cc3ccccc3)C2)OC1

$$$$
SWF003956
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    6.7681   -0.3752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4372   -1.1183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0989    0.3680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5112    0.2939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003956

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2CN(C(=O)COc3cc(F)ccc3F)C[C@@H]21

$$$$
SWF003957
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5048    3.4524   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1036    2.4343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9170    4.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5158    3.2433   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9225    4.1569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4788    3.1388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8855    2.2253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8636    2.0173   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3855    1.3592   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9682    1.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0546    0.6161   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003957

>  <SMILES>
O=C(NCc1ccccc1)C1CC2(CO1)CN(Cc1c[nH]cn1)CCO2

$$$$
SWF003958
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5527   -1.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8910    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5427    4.5089   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003958

>  <SMILES>
COCC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF003959
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.4477   -1.2864   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2398   -0.3082   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5816   -1.7864   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2452   -0.2037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8385   -1.1173   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2452    1.5283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452    2.3944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3799   -0.2686   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    2.3944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003959

>  <SMILES>
O=C(CC1(O)CCC1)N1CCc2ncnc(-c3ccsc3)c2CC1

$$$$
SWF003960
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    8.6451   -9.6073   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8951   -8.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5961   -9.0583   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1451   -7.0092   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -7.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -8.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7923   -3.0583   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -3.0583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  2  0  0  0  0
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 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003960

>  <SMILES>
COCCN1C[C@@H]2CN(C(=O)c3ccnc(C(F)(F)F)c3)C[C@@H]2C1=O

$$$$
SWF003961
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6971    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7216    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2809    0.8104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4746    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2118    1.1757   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    3.1906   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5384    2.7602   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 20 23  2  0  0  0  0
 12 14  1  0  0  0  0
 18 19  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003961

>  <SMILES>
Cc1ccccc1CCC(=O)N1Cc2ccnn2CCC1CO

$$$$
SWF003962
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.9407   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5340   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1218   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8703   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1163   -2.1435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003962

>  <SMILES>
O=C(c1ccccc1)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF003963
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003963

>  <SMILES>
COCC12CCCOC1CCN(C(=O)c1ccc(C)nc1)C2

$$$$
SWF003964
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6044   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6044   -4.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6044   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6044   -4.8147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003964

>  <SMILES>
COc1ccc(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@H]3C2)cn1

$$$$
SWF003965
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.2160    1.1086   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3887    2.0438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7850    1.4958   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1651    3.5271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3379    4.4623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1365   -0.8450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2706    5.9608   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7838    4.0632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5698   -0.4028   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
 20 21  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003965

>  <SMILES>
O=C(Cc1ccco1)N1Cc2ccnn2CCC1COc1cnccn1

$$$$
SWF003966
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 15  1  0  0  0  0
 12 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003966

>  <SMILES>
Cc1cccnc1C(=O)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF003967
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1340    3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003967

>  <SMILES>
Cc1ncc(C(=O)N2C[C@@H]3OCCN(c4cnccn4)[C@H]3C2)cn1

$$$$
SWF003968
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9063   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  1  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 13 17  1  0  0  0  0
 18 20  1  0  0  0  0
 21 22  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003968

>  <SMILES>
O=S(=O)(c1ccc2ncsc2c1)N1C[C@@H]2OCCN(c3cnccn3)[C@H]2C1

$$$$
SWF003969
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7087    2.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452    3.8083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9818    6.2353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2020    8.9760   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8121   10.3463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4387   11.4030   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10  9  1  1  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF003969

>  <SMILES>
O=C(NCCCn1ccnc1)C1=NOC2(CCCN(Cc3ccccc3)C2)C1

$$$$
SWF003970
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.1004   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3139   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4519   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0106    4.2267   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9087    2.6996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003970

>  <SMILES>
COCCN1CCC2(CN(Cc3cncc(C)n3)CC(F)(F)C2)C1=O

$$$$
SWF003971
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  2  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  5  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003971

>  <SMILES>
CC(C)c1snnc1C(=O)NC1CC2(CCN(Cc3ccccc3)CC2)C1

$$$$
SWF003972
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5264    3.4679   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003972

>  <SMILES>
CNC(=O)C1=NOC2(CCCN(Cc3ccc(F)cc3F)C2)C1

$$$$
SWF003973
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003973

>  <SMILES>
CN1C(=O)c2cccnc2C12CCN(C(=O)/C=C/c1cccs1)CC2

$$$$
SWF003974
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  7  6  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003974

>  <SMILES>
Cn1cc(CN2Cc3ccnn3C(CNS(C)(=O)=O)C2)cn1

$$$$
SWF003975
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3364   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8364   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  8  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003975

>  <SMILES>
Cc1ncc(C(=O)N2C[C@@H]3OCCN(Cc4csc(C)n4)[C@H]3C2)cn1

$$$$
SWF003976
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.2864    1.9677   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5561    0.7896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1958   -0.6765   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8509   -0.1659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1707   -0.8990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2459   -0.2314   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2903    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1113   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1224   -2.1774   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5586   -2.9227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9586   -3.1639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF003976

>  <SMILES>
COCCC1CN(Cc2ccccc2F)Cc2cccn2C1

$$$$
SWF003977
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3272   -3.7213   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0182   -4.6723   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  1  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  6  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  1  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF003977

>  <SMILES>
CO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)CCc1ccccc1F

$$$$
SWF003978
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2094   -1.7364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5150   -3.8734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0678   -2.2493   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5110   -3.9631   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9024   -1.6984   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2020   -3.2403   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7968   -2.1457   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8426   -0.7002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5061    0.0479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0944   -0.0366   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7580    0.7115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6982    1.7097   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003978

>  <SMILES>
CC(C)CNC(=O)c1ncn2c1CN(C(=O)C1CC(O)C1)CCC2

$$$$
SWF003979
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.5981    0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8040    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6994    1.4854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7821    0.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6130    1.8921   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2821    1.1489   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2766    1.2535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  1  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  3  4  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003979

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)[C@@H]4C[C@H]4F)C3)CC2=O)cn1

$$$$
SWF003980
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9271   -0.1251   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4008   -1.3661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1908   -1.8611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3020   -1.0522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 12  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003980

>  <SMILES>
O=C(N1CCC2(CCCN(c3ncccn3)C2)CC1)C12CC(C1)C2

$$$$
SWF003981
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7759   -4.2898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8249   -4.5988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5191   -4.9589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6170   -5.5769   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3112   -5.9370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3601   -6.2460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  1  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF003981

>  <SMILES>
C[C@@H]1CN(C(=O)c2cc[nH]n2)C[C@]12CCN(c1cccnc1)C2=O

$$$$
SWF003982
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6261    1.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9781   -0.7079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1691   -2.1092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9538    3.3479   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3692    1.9479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5471    4.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3474    1.7400   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2647    2.9424   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8474    2.6060   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1783    3.3492   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3862    4.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  6  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF003982

>  <SMILES>
CO[C@H]1CCN(C(=O)[C@H]2[C@@H]3COC[C@@H]32)[C@H]1Cc1cnn(C)c1

$$$$
SWF003983
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    1.9367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6573    3.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139    2.2314   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904    4.1774   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792    3.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0956    5.1329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792    4.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7758    5.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1207    5.3555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4810    6.8216   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8259    6.3110   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1612    7.5546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5061    7.0441   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8414    8.2877   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  3  0  0  0  0
 10 15  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003983

>  <SMILES>
N#Cc1cccc(N2CCOCC3(CCCN(C(=O)c4cc[nH]c4)C3)C2)c1

$$$$
SWF003984
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0747   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8262    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7818   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6472   -2.0283   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1472   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945   -2.9227   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3821   -3.6245   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3999   -3.6112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4597   -4.6094   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3024   -5.1477   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3127   -5.2445   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0508   -6.1156   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0526   -6.1754   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2806   -4.9929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF003984

>  <SMILES>
Cc1cnnn1Cc1nnn2c1CN(C(=O)c1csnn1)CCC2

$$$$
SWF003985
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   11.1192    4.4017   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.4182    3.6517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.4182    5.1517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    3.1027   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    5.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    7.2008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0702    6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8  9  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003985

>  <SMILES>
O=C(NCCc1ccncc1)[C@@H]1C[C@@H]2CCN(S(=O)(=O)C3CC3)C[C@H]2O1

$$$$
SWF003986
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   -3.9684   -4.3601   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -3.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -2.2582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -1.9463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003986

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(=O)c2cccs2)CC1

$$$$
SWF003987
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    2.2478    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2423    2.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6491    3.2614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5827    3.6198   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2907    4.1950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2243    4.5534   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6310    5.4669   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  6  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 20 25  2  0  0  0  0
 21 26  1  0  0  0  0
 24 27  2  0  0  0  0
 26 28  1  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003987

>  <SMILES>
COCCN1c2cccnc2-n2cccc2C12CCN(C(=O)C1CC(O)C1)C2

$$$$
SWF003988
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7159   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9557   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8538   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1759    1.7996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5308    5.4402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0391    5.2834   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003988

>  <SMILES>
O=C(c1cnccn1)N1CC(F)(F)CC2(CCN(CC3CC3)C2=O)C1

$$$$
SWF003989
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF003989

>  <SMILES>
CCC(=O)N1CCC(Nc2cccc(OC)c2)(C(=O)NC)CC1

$$$$
SWF003990
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.6313   -5.6710   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5822   -4.7893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8448   -4.7893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1187   -3.3628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0088   -5.2529   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3813   -3.3628   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1235   -4.2492   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5501   -4.7127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8116   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9264   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF003990

>  <SMILES>
c1ccc(OCCC2CCOC23CCN(Cc2ccco2)CC3)nc1

$$$$
SWF003991
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   11.0825   -2.1946   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.0788   -3.3093   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5461   -3.6212   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9678   -1.1909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.5091   -1.7311   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2797    0.2763   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5412   -1.6544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6238   -2.7348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8210   -0.2639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1649    1.2800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   15.0504   -2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2476    0.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF003991

>  <SMILES>
CCCN1C[C@H]2C(=O)NC3(CCN(S(=O)(=O)c4ccccc4)CC3)[C@H]2C1

$$$$
SWF003992
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF003992

>  <SMILES>
COc1ccc(C(=O)N2CC3(CC(N4CCOCC4)CS3)C2)cn1

$$$$
SWF003993
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    5.9020   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  6  0  0  0
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 11 14  1  0  0  0  0
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 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF003993

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)NC(=O)[C@@H]2CN(CC(C)C)C[C@@H]23)c1

$$$$
SWF003994
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF003994

>  <SMILES>
CO[C@H]1CCN(C(=O)C2CC(F)(F)C2)[C@H]1Cc1cnn(C)c1

$$$$
SWF003995
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF003995

>  <SMILES>
CCS(=O)(=O)N1CCC(C2CCCCN2Cc2cccc(OC)c2)CC1

$$$$
SWF003996
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0494   -1.7995   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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  5  7  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003996

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(Cc4ccccc4)C3)C2)c1

$$$$
SWF003997
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 17 19  2  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003997

>  <SMILES>
COc1ccccc1-c1n[nH]c2c1CCN(C(=O)c1ccc(O)cc1)CC2

$$$$
SWF003998
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 15  1  1  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 11 16  1  0  0  0  0
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 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF003998

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF003999
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.5442   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF003999

>  <SMILES>
O=C(c1ccc(O)cc1)N1CCC2(CC1)COC(CN1CCOCC1)C2

$$$$
SWF004000
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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    6.1667    1.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 22 27  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 23 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004000

>  <SMILES>
CC(C)NC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2ccsc2)CC1

$$$$
SWF004001
Actelion Java MolfileCreator 1.0

 26 27  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3660    1.1340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3660    2.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004001

>  <SMILES>
CC(C)NC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C(C)(C)C)CC1

$$$$
SWF004002
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004002

>  <SMILES>
CC(C)NC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C(C)C)CC1

$$$$
SWF004003
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004003

>  <SMILES>
C=CC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC(C)C)CC1

$$$$
SWF004004
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5731   -4.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1589   -4.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -5.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004004

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(=O)C2CCC2)CC1

$$$$
SWF004005
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1240   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6260   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1240   -7.7498   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -9.0488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 13 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004005

>  <SMILES>
Cc1csc(C(=O)N2C[C@@H]3OCCN(c4ccnc(C)c4)[C@H]3C2)c1

$$$$
SWF004006
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2522   -3.6979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -2.5985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5421   -5.1696   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6212   -3.7987   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9579   -3.2455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8735   -5.8606   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2438   -5.2505   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0929   -3.5088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0494   -1.7995   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5908   -0.9597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5342   -0.3800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0756    0.4597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5473    0.7496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0059   -0.0901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 12 18  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
  5  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004006

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(Cc4c(C)noc4C)C3)C2)c1

$$$$
SWF004007
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <HTSID>
SWF004007

>  <SMILES>
Cn1nccc1CN1CCCC2(CCCN(C(=O)c3cncnc3)C2)C1

$$$$
SWF004008
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2522   -3.6979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0494   -1.7995   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5342   -0.3800   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0059   -0.0901   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
  6  7  1  0  0  0  0
 17 21  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004008

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(C(C)c4ccccc4)C3)C2)c1

$$$$
SWF004009
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5883   -5.8701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004009

>  <SMILES>
CCN1C[C@H]2C3(CCN(C(C)=O)CC3)CC[C@@]2(C(=O)NC)C1

$$$$
SWF004010
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5073    6.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004010

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)C(=O)N(CCO)CCN3C)C1

$$$$
SWF004011
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   10.1908   -4.9515   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.7272   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  2  0  0  0  0
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  6  7  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 23 24  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004011

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(C(=O)C1CC(F)(F)C1)C2

$$$$
SWF004012
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.3433   -6.8083   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8433   -6.8083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8797   -5.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3068   -5.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004012

>  <SMILES>
CN(C)Cc1cncc2c1CCN(C(=O)c1csnn1)C2

$$$$
SWF004013
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783   -0.1727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2837   -5.4802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3492   -4.8565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004013

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)c2ncccc2C(=O)N3C)cn1

$$$$
SWF004014
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    3.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  1  0  0  0
  9 12  1  6  0  0  0
 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 17  1  0  0  0  0
 19 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004014

>  <SMILES>
O=C(CCN1CCOCC1)N1C[C@@H]2OCCN(c3ncccn3)[C@H]2C1

$$$$
SWF004015
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 20 25  1  0  0  0  0
 21 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004015

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccccn1)C2

$$$$
SWF004016
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    5.7342   -2.5607   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.4595    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 20 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004016

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)C1CC(F)C1)C2

$$$$
SWF004017
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7688   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9221   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2770   -7.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3789   -9.2484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4972  -10.4620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004017

>  <SMILES>
CCN(C)CC1CC2(CCN(C(=O)c3ccc(O)cc3)CC2)CO1

$$$$
SWF004018
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0934   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004018

>  <SMILES>
Cc1nc(CN2CCCC3(CCCN(C(=O)c4sc(C)nc4C)C3)C2)cs1

$$$$
SWF004019
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6261    4.4507   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3692    3.7816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8340    5.4289   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3203    4.0906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1613    2.8034   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5282    5.0688   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 17 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004019

>  <SMILES>
Cc1ccccc1-c1n[nH]c2c1CCN(C(=O)c1ccc(O)cc1)CC2

$$$$
SWF004020
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -3.3480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -3.3480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7990    5.1073   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2010    5.1073   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.9510    1.2102   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2010    2.5092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004020

>  <SMILES>
Cc1cccc(CN2CCO[C@H]3CN(C(=O)C4CC4(C)C)C[C@@H]32)n1

$$$$
SWF004021
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    9.0950    2.9345   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.0950    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004021

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@@H]2CCN(C(=O)C3CC(F)C3)C[C@@H]2O1

$$$$
SWF004022
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004022

>  <SMILES>
Cc1ccnc(N2CCCC3(CCCN(C(=O)c4ncccc4C)C3)C2)n1

$$$$
SWF004023
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4423   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0524   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1707   -7.8781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5442   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1543   -8.1917   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4259   -5.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6461   -8.3485   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9176   -5.7647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5278   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004023

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccccc3)CC2)CN1Cc1cccnc1

$$$$
SWF004024
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0933   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8433   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5933    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1833   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0814   -3.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6915   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  1  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 15  1  0  0  0  0
 14 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004024

>  <SMILES>
CNC(=O)CC1CN(S(=O)(=O)c2ccccc2C)Cc2ccnn21

$$$$
SWF004025
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.8486   -2.9533   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3155   -2.6403   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7791   -1.2136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3193   -3.7551   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2058   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7866   -3.4432   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8558   -5.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5982   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7791    1.2136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2872    1.3704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2058    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7904   -4.5580   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8595   -6.2965   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5974   -2.2479   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3268   -5.9847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3306   -7.0994   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4490   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3883   -2.1990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8372   -1.8108   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  2  0  0  0  0
  9 15  2  0  0  0  0
  9 16  1  0  0  0  0
 13 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004025

>  <SMILES>
Cc1ncc(C(=O)N2CCC3CC32C(=O)NC2CCC2)cn1

$$$$
SWF004026
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8338    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3048    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  1  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  6  0  0  0
 19 22  2  0  0  0  0
  9 12  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004026

>  <SMILES>
C[C@H]1C[C@H]2CN(C(=O)Cc3noc4ccccc34)CC[C@@H]2O1

$$$$
SWF004027
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3399   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3399   -5.7971   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0093   -4.1572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7958   -2.0553   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0130   -3.0425   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2630   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 22 25  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004027

>  <SMILES>
O=C(NCc1ccccc1)c1nc2c(s1)CCN(C(=O)c1cc[nH]c1)CC2

$$$$
SWF004028
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    2.2478    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2423    2.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8301    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6272    3.4693   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7318    4.4638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1472   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 20 25  1  0  0  0  0
 21 26  2  0  0  0  0
 22 27  1  0  0  0  0
 25 28  2  0  0  0  0
 27 29  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004028

>  <SMILES>
COCCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccc(C)o1)C2

$$$$
SWF004029
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.2478    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2423    2.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5211    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6436    3.3659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 20 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  1  0  0  0  0
  8  9  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004029

>  <SMILES>
COCCN1c2cccnc2-n2cccc2C12CCN(C(=O)CC(C)C)C2

$$$$
SWF004030
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 20 25  1  0  0  0  0
 23 26  2  0  0  0  0
  8  9  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004030

>  <SMILES>
CCCN1c2cccnc2-n2cccc2C12CCN(C(=O)CC(C)C)C2

$$$$
SWF004031
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    9.1457    4.4008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.8433   10.3840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
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 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004031

>  <SMILES>
COCc1ccc(C(=O)N2CCc3ncnc(NC4CC4)c3CC2)cc1

$$$$
SWF004032
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.4655   -1.8546   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.1707   -0.8990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.8258   -0.3885   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 15 17  1  0  0  0  0
 19 20  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004032

>  <SMILES>
Fc1ccc(CN2Cc3ccnn3CC(COCC3CC3)C2)cc1F

$$$$
SWF004033
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7551   -3.5996   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7061   -3.2905   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1673   -2.7905   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4679   -0.8226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
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 12 14  1  0  0  0  0
 15 16  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004033

>  <SMILES>
O=C(c1csnn1)N1CCn2c(CNc3cccnc3)nnc2C1

$$$$
SWF004034
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004034

>  <SMILES>
C[C@@H]1CN(C(=O)C2(F)CC2)C[C@]12CCN(c1cccnc1)C2=O

$$$$
SWF004035
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004035

>  <SMILES>
COc1ccc(C(=O)N2CC3(CC(NCC4CC4)CS3)C2)cn1

$$$$
SWF004036
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.3792   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004036

>  <SMILES>
c1cnc(N2CCC3(COCCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF004037
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 16  1  0  0  0  0
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 13 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 12 17  1  0  0  0  0
 14 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004037

>  <SMILES>
O=C(c1ccccn1)N1CCOCC2(CCC(Cn3cncn3)O2)C1

$$$$
SWF004038
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4389    5.1786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004038

>  <SMILES>
CC1CC(C(=O)N2CC[C@@]3(C[C@H](Nc4ccccn4)CCO3)C2)C1

$$$$
SWF004039
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1941   -4.9787   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2632   -4.6133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004039

>  <SMILES>
O=C(C1CCOC1)N1C[C@@H]2CN(Cc3ccoc3)CCO[C@@H]2C1

$$$$
SWF004040
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  4  8  1  0  0  0  0
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 12 10  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004040

>  <SMILES>
O=C(C[C@@H]1CO[C@@H]2CN(C(=O)C3(F)CCC3)C[C@H]12)NCc1cccnc1

$$$$
SWF004041
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6939   -2.3647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004041

>  <SMILES>
O=C(c1cnco1)N1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF004042
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.7832   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  1  0  0  0
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M  END
>  <HTSID>
SWF004042

>  <SMILES>
Cc1cccc(C(=O)N2C[C@@H]3[C@@H](CNC(=O)C4CC(F)(F)C4)CO[C@@H]3C2)c1

$$$$
SWF004043
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11  7  1  6  0  0  0
  8 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004043

>  <SMILES>
CC1CC(C(=O)N2CC[C@H]3C[C@H](C(=O)N4CCOCC4)O[C@H]3C2)C1

$$$$
SWF004044
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004044

>  <SMILES>
O=C(C1CC1)N1CCCC2(CCN(Cc3ccncc3)C2=O)C1

$$$$
SWF004045
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    9.0933    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004045

>  <SMILES>
Cn1cnc(S(=O)(=O)N2C[C@@H](C(=O)NCc3cccnc3)C[C@H]3OCC[C@H]32)c1

$$$$
SWF004046
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  1  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004046

>  <SMILES>
O=C(c1ccnc(F)c1)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF004047
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9218   -0.4635   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 18 22  1  0  0  0  0
 10 13  2  0  0  0  0
 17 21  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004047

>  <SMILES>
COCC1Cc2c(ncn2C)CN1C(=O)Cc1ccccn1

$$$$
SWF004048
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.5211    4.4017   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8201    3.6517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8201    5.1517   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7711    3.1027   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7711    5.7008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3812    7.0711   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2794    5.8576   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2665    8.0748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  1  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 11  1  1  0  0  0
 12 13  2  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004048

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CCN(S(=O)(=O)c3sccc3C)C[C@@H]2O1

$$$$
SWF004049
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004049

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF004050
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 24 26  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004050

>  <SMILES>
O=C(c1ccnnc1)N1C[C@H]2[C@@H](CCOCc3ccccn3)CO[C@H]2C1

$$$$
SWF004051
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004051

>  <SMILES>
O=C(CCF)N1CCC2(CCC(=O)N2Cc2cccc(F)c2)CC1

$$$$
SWF004052
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004052

>  <SMILES>
CCS(=O)(=O)NCC1CCC2(CN(Cc3cccc(C)c3)C2)OC1

$$$$
SWF004053
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004053

>  <SMILES>
Cc1ccc(CN2CC3(CC(OCc4ccccn4)CS3)C2)cc1

$$$$
SWF004054
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    7.7942   -3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 14  2  0  0  0  0
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 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  7  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <HTSID>
SWF004054

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC1)CNS(=O)(=O)c1cnc(N3CCCC3)nc12

$$$$
SWF004055
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   -3.9684   -4.3601   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -3.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -2.2582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -1.9463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004055

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(Cc3cccs3)CC2)c1

$$$$
SWF004056
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -3.9341   -9.0853   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -8.3282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3114   -9.0853   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6227   -6.8140   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.3282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3114   -6.0569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.7856   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5735    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9341    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004056

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(Cc2ccc(F)cc2)C1

$$$$
SWF004057
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
  9 10  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004057

>  <SMILES>
C=CC(=O)N1CCC(Nc2ccnn2C)(C(=O)N(C)C)CC1

$$$$
SWF004058
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0980   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3480   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8322    2.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9505    3.6375   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3240    2.5808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5606    5.0078   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9341    3.9511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0524    5.1646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6625    6.5349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004058

>  <SMILES>
Cc1ccc(N2CCC3(CN(C(=O)Cc4cccc(F)c4F)CCC3(F)F)C2)nn1

$$$$
SWF004059
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2570   -3.4182   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471   -5.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471   -5.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004059

>  <SMILES>
COc1cccc(C(=O)N2CC(F)(F)CC3(CCNC3=O)C2)c1

$$$$
SWF004060
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 15  1  0  0  0  0
 17 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004060

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(CC3CCCCC3)CC2)c1

$$$$
SWF004061
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2809    5.7002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1944    6.1069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0035    5.5191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 11 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004061

>  <SMILES>
O=C(c1ccccn1)N1CCC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF004062
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -4.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004062

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF004063
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889   -0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -4.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004063

>  <SMILES>
COCC1CCN(C)C2(C1)CN(C(=O)c1cccc(O)c1)C2

$$$$
SWF004064
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.9757    0.5933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004064

>  <SMILES>
COCCNC(=O)C1(Nc2nccs2)CCN(C(C)=O)CC1

$$$$
SWF004065
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    8.4128    4.6665   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4128    4.6665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9128    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9128    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
 13 15  2  0  0  0  0
 16 14  1  1  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004065

>  <SMILES>
c1cc(CN2CCCC(c3nc4ccc(-c5ccncc5)cn4n3)C2)ccn1

$$$$
SWF004066
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   10.4280    3.3370   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.7398    1.8698   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.8545    2.8735   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9608    3.0251   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8915    4.7636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4972    1.5986   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3587    5.0755   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0300    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5009    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8223    6.5021   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3513    7.3049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8186    7.6168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004066

>  <SMILES>
O=C(NCC1CC1)c1noc2c1CC(NS(=O)(=O)c1cccnc1)CC2

$$$$
SWF004067
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004067

>  <SMILES>
CN(C)Cc1cncc2c1CCN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)C2

$$$$
SWF004068
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
    9.5489   -5.6294   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5420   -4.5112   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7965   -6.9325   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1674   -5.1232   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3247   -6.6197   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4898   -4.9829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6995   -1.9452   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    9.4769   -0.7867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3746   -0.1403   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1573   -2.2488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
 10  7  1  6  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004068

>  <SMILES>
O=C1N(c2ccsc2)CC[C@]12CN(Cc1cn[nH]c1)C[C@H]2c1ccccc1

$$$$
SWF004069
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    2.8835    4.9707   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5407    4.2170   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5220    4.4093   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2166    3.2710   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1793    3.6556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2607    2.9771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7914    2.4527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1606    3.8480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2448    1.9772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1909    1.6531   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8178    3.0943   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4912    1.3200   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3832    0.6718   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6835    0.3387   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2983   -1.7526   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0832   -3.6348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 24 21  1  1  0  0  0
 25 22  1  6  0  0  0
 26 23  1  1  0  0  0
 24 27  1  0  0  0  0
 24 28  1  0  0  0  0
 25 29  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004069

>  <SMILES>
COCCNC(=O)c1cn2c(n1)C(C)N(C(=O)C13C[C@H]4C[C@@H](C1)C[C@@H](C3)C4)CC2

$$$$
SWF004070
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452   -5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2452   -3.2010   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  2  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 20 24  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004070

>  <SMILES>
COc1cccc(NC2(C(=O)NC3CC3)CCN(S(C)(=O)=O)CC2)c1

$$$$
SWF004071
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004071

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(C)=O)CC1

$$$$
SWF004072
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9505   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4423   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2942   -8.1204   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5479   -5.7067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9182   -6.3168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 22 19  1  1  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004072

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)C4CCOC4)CC3)CC2=O)cc1

$$$$
SWF004073
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004073

>  <SMILES>
CNC(=O)C[C@@H]1C[C@H]2CN(C(=O)c3ccccc3C)C[C@H]2O1

$$$$
SWF004074
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.7549   -2.2418   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004074

>  <SMILES>
O=C(c1ccns1)N1CCCC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF004075
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   10.4596    1.5388   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.5936    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5936    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7275    3.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8615    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2634    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004075

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@@H]2C[C@@H](COc3cncc(Cl)c3)O[C@@H]2C1

$$$$
SWF004076
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    5.6778   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7710   -0.3862   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  6  2  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004076

>  <SMILES>
O=C1NC(c2ccccc2)=N[C@@]12CC[C@@H]1CN(Cc3cn[nH]c3)C[C@@H]12

$$$$
SWF004077
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    8.2153    3.2386   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.2208    3.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8141    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2318    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6915    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  1  1  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004077

>  <SMILES>
COCCO[C@@H]1CCN(C(=O)CCF)[C@H]1Cc1ccccc1

$$$$
SWF004078
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004078

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(Cc2ccccc2)CC1

$$$$
SWF004079
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    3.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    3.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2218    5.3479   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0873    6.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2218    5.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7218    6.8867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5308    6.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004079

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(CC1)CC(N1CCCC1)CO2

$$$$
SWF004080
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004080

>  <SMILES>
Cc1ccccc1C(=O)N1CCCC(Nc2ccccc2)(C(=O)N(C)C)C1

$$$$
SWF004081
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    0.1805   -2.9444   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0465   -2.4444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5626   -2.2753   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8386   -1.4663   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9601   -2.8511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1559   -1.3617   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7872   -3.6646   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4917   -2.0823   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -0.1636   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  6  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004081

>  <SMILES>
COCCNC(=O)[C@@]12CCO[C@@H]1CCN(C(=O)/C=C/c1cccs1)C2

$$$$
SWF004082
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0539    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2711    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7711    3.1027   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5211   -0.7944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0211   -0.7944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7711   -2.0935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7711   -2.0935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5211   -3.3925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0211   -3.3925   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  6  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 22 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004082

>  <SMILES>
Cc1nc(C(=O)N2CCOC(c3cn4c(-c5ccncc5)cccc4n3)C2)cs1

$$$$
SWF004083
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 26  2  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004083

>  <SMILES>
Cc1cccnc1CN1CCCC(Nc2ccccc2)(C(=O)N(C)C)C1

$$$$
SWF004084
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004084

>  <SMILES>
CCS(=O)(=O)NCCC1CN(Cc2ccc(C)cc2)Cc2ccnn21

$$$$
SWF004085
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.6647    1.8841   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602    2.8786   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511    1.4774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004085

>  <SMILES>
CCO[C@H]1CCN(C(=O)c2csnn2)[C@H]1Cc1ccccc1

$$$$
SWF004086
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  6  8  1  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004086

>  <SMILES>
CN1C(=O)c2cccn2C2CN(C(=O)c3ccnc(F)c3)CC21

$$$$
SWF004087
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9  8  1  1  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004087

>  <SMILES>
CNC(=O)C1=NOC2(CCCN(Cc3ccc(OC)cc3)C2)C1

$$$$
SWF004088
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004088

>  <SMILES>
Cc1ccoc1C(=O)N1CC2(CC(OCC(=O)N(C)C)CS2)C1

$$$$
SWF004089
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.4882   -6.2031   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004089

>  <SMILES>
COCCN1CC(COC)C2(CCN(Cc3ccc(C)o3)CC2)C1

$$$$
SWF004090
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.7511   -2.2908   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004090

>  <SMILES>
COCC1CN(Cc2csc(C)n2)CC12CCN(C)CC2

$$$$
SWF004091
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004091

>  <SMILES>
CCS(=O)(=O)NCCC1CCOC12CN(Cc1cccs1)C2

$$$$
SWF004092
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004092

>  <SMILES>
CC(C)N1CCC(Nc2cccc(F)c2)(C(=O)NC2CC2)CC1

$$$$
SWF004093
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -7.3713   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 21  1  0  0  0  0
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  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004093

>  <SMILES>
COC1CCOC2(C1)CN(C(=O)C1Cc3ccccc3O1)C2

$$$$
SWF004094
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    6.0622   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004094

>  <SMILES>
COc1ccc(CN2CCOC3(COC(C(=O)NCc4ccc(F)cc4)C3)C2)cc1

$$$$
SWF004095
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004095

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(=O)C(C)C)CC1

$$$$
SWF004096
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004096

>  <SMILES>
COCCC1CCOC12CCN(Cc1ccc(C)s1)CC2

$$$$
SWF004097
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF004097

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(C(=O)c2ccccc2C)CC1

$$$$
SWF004098
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004098

>  <SMILES>
COCCN1C[C@@H]2CN(C(=O)c3ccc(OC)cc3C)C[C@@H]2C1=O

$$$$
SWF004099
Actelion Java MolfileCreator 1.0

 32 36  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 18 24  1  0  0  0  0
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 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 30 32  1  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 27  1  0  0  0  0
 22 24  2  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004099

>  <SMILES>
Cn1ccc(C(=O)N2C[C@@H](c3ccnn3C)[C@@]3(CCCN(Cc4ccncc4)C3=O)C2)n1

$$$$
SWF004100
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004100

>  <SMILES>
CCCNC(=O)c1nc(-c2ccn(CCN(C)C)c2)n2ccccc12

$$$$
SWF004101
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  2  0  0  0  0
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 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
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 10 11  2  0  0  0  0
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 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004101

>  <SMILES>
CC1CC(C(=O)N2CCC3(C2)Cn2c(nnc2C(=O)NC2CCC2)CO3)C1

$$$$
SWF004102
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004102

>  <SMILES>
CN(C)Cc1noc2c1CC(NS(=O)(=O)c1cccc(F)c1)CC2

$$$$
SWF004103
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 11 14  2  0  0  0  0
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 15 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 19 22  2  0  0  0  0
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 20 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004103

>  <SMILES>
COc1cccc(NC2(C(=O)NC3CC3)CCN(C(C)=O)CC2)c1

$$$$
SWF004104
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
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   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
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 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 12 15  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004104

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(C(C)=O)CC2)c1

$$$$
SWF004105
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2654   -6.5218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004105

>  <SMILES>
CN1CCC2(CN(C(=O)c3ncccn3)CC(F)(F)C2)C1=O

$$$$
SWF004106
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   13.4569    7.4037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.9651    7.5605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7688    5.9365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3550    6.1902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4697    5.1865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8878    5.8783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4243    4.4517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9570    4.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4280    3.3370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4935    2.7133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0300    1.2867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5009    0.4838   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0374   -0.9427   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004106

>  <SMILES>
CCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2ccsc2)CC1

$$$$
SWF004107
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  6  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004107

>  <SMILES>
CN(C)C(=O)N1CCCC(c2nc3ccc(-c4ccncc4)cn3n2)C1

$$$$
SWF004108
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    3.6641    1.7358   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9895   -0.1406   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3746   -2.3819   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1546   -0.2689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 24 27  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF004108

>  <SMILES>
O=C(c1ccco1)N1CC(c2nccs2)C2(CCN(CC3CCC3)C2=O)C1

$$$$
SWF004109
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004109

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC1)Cc1ncc(-c3cccnc3)n1C2

$$$$
SWF004110
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -3.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301   -3.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301   -2.1340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  2  0  0  0  0
  9 10  1  0  0  0  0
 20 24  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004110

>  <SMILES>
CS(=O)(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC2CC2)CC1

$$$$
SWF004111
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004111

>  <SMILES>
CNC(=O)CC1CN(Cc2cc(C)ccc2C)Cc2ccnn21

$$$$
SWF004112
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -2.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -2.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004112

>  <SMILES>
CC1(C(=O)NC2CC3(CCN(Cc4cccnc4)CC3)C2)CC1

$$$$
SWF004113
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    3.9408   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6992    1.3136   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1824    1.3136   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6272   -0.7584   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8816   -0.7584   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 12 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 10 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004113

>  <SMILES>
CCCS(=O)(=O)N1CCCC(C(=O)NC)(n2cccn2)C1

$$$$
SWF004114
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7570    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
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 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004114

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(Cc2ccccn2)C3)n1

$$$$
SWF004115
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004115

>  <SMILES>
Cc1ccccc1OCC(=O)N1Cc2ccnn2CCC1CO

$$$$
SWF004116
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004116

>  <SMILES>
O=C(COc1cccc(Cl)c1)N1Cc2ccnn2CCC1CO

$$$$
SWF004117
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
    6.0622   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 28 31  1  0  0  0  0
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 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF004117

>  <SMILES>
O=C(NCc1ccc(F)cc1)C1CC2(CO1)CN(Cc1ncc(C(F)(F)F)[nH]1)CCO2

$$$$
SWF004118
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6647   -1.8841   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004118

>  <SMILES>
COCC1CN(Cc2ccsc2)CC12CCN(C(C)C)CC2

$$$$
SWF004119
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004119

>  <SMILES>
c1ccc(CN2CC3(CC(OCc4ccccn4)CS3)C2)cc1

$$$$
SWF004120
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5749    5.7558   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7659    5.1680   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  2  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
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 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004120

>  <SMILES>
c1ccc(COC2CSC3(C2)CN(Cc2ccoc2)C3)nc1

$$$$
SWF004121
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.1617   -0.1652   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4781    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0767    2.1316   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7606   -2.5306   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 10 11  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004121

>  <SMILES>
Cc1ccnc(C(=O)N2CCC3(C2)CN(C)S(=O)(=O)c2ccccc2O3)c1

$$$$
SWF004122
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.3456   -3.8113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.4474   -2.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004122

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)CCN(c2cccnc2)C3=O)cs1

$$$$
SWF004123
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004123

>  <SMILES>
O=C(c1ccnc(F)c1)N1CCOCC2(CCN(c3ccccn3)C2)C1

$$$$
SWF004124
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004124

>  <SMILES>
COc1ccc(C(=O)N2C[C@@H]3CN(C)CCO[C@@H]3C2)c(OC)c1

$$$$
SWF004125
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8745   -6.5607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004125

>  <SMILES>
CCN1CCOC2CN(C(=O)[C@H]3CC[C@H](C)CC3)CCC2C1

$$$$
SWF004126
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004126

>  <SMILES>
COCC1CN(S(C)(=O)=O)CC12CCN(C(=O)CC1CC1)CC2

$$$$
SWF004127
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004127

>  <SMILES>
Cc1ccc(CN2CC3(CC(OCc4cccc(C)n4)CCO3)C2)cc1

$$$$
SWF004128
Actelion Java MolfileCreator 1.0

 31 35  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004128

>  <SMILES>
Cn1nccc1[C@@H]1CN(Cc2ccccn2)C[C@]12CCCN(Cc1ccccc1)C2=O

$$$$
SWF004129
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004129

>  <SMILES>
COCC1CN(Cc2ccco2)CC12CCN(C1CCC1)CC2

$$$$
SWF004130
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004130

>  <SMILES>
COCC1CN(Cc2cccs2)CC12CCN(C(C)C)CC2

$$$$
SWF004131
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004131

>  <SMILES>
COc1cnc(C(=O)N2CC3(CC(N4CCCCC4)CS3)C2)cn1

$$$$
SWF004132
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.6647   -1.8841   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004132

>  <SMILES>
COCC1CN(Cc2ccsc2)CC12CCN(CC1CCC1)CC2

$$$$
SWF004133
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0190   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 18  3  0  0  0  0
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 17 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  9  1  0  0  0  0
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 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004133

>  <SMILES>
CCOCCC1CCOC2(C1)CN(C(=O)c1cccc(C#N)c1)C2

$$$$
SWF004134
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004134

>  <SMILES>
O=C(c1ccnc(F)c1)N1C[C@H](N2CCOCC2)[C@@H]2OCCC[C@@H]21

$$$$
SWF004135
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.1529    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
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 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004135

>  <SMILES>
CC(C)C(=O)NCC1CCC2(CN(C(=O)C3CC3C)C2)OC1

$$$$
SWF004136
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0701   -4.2048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 15 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004136

>  <SMILES>
Cc1cccnc1C(=O)N1CC2(CC(NC3CCC3)CS2)C1

$$$$
SWF004137
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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    1.7321    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  7  8  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004137

>  <SMILES>
O=C(CN1CCCC2(CCCN(C(=O)c3ncc(F)cc3F)C2)C1)N1CCCC1

$$$$
SWF004138
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004138

>  <SMILES>
Cc1cccc(C(=O)N2CC3(CCC(CN4CCCC4)CO3)C2)c1

$$$$
SWF004139
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    2.6272   -0.7584   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 10 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004139

>  <SMILES>
CCS(=O)(=O)N1CCCC(C(=O)N(C)C)(n2ccnc2)C1

$$$$
SWF004140
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004140

>  <SMILES>
CCN(CC)C(=O)C1Cn2ccnc2C2(CCN(C(=O)CCF)CC2)O1

$$$$
SWF004141
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004141

>  <SMILES>
COCCC1CCOC2(C1)CN(C(=O)c1cccc(C)c1)C2

$$$$
SWF004142
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    9.8850   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004142

>  <SMILES>
COCC(=O)NCC1CCC2(CN(C(=O)CC(C)C)C2)OC1

$$$$
SWF004143
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004143

>  <SMILES>
O=C(c1ccco1)N1CC2Oc3ncccc3S(=O)(=O)N(Cc3ccccn3)C2C1

$$$$
SWF004144
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004144

>  <SMILES>
CNC(=O)c1nnc2n1CC1(CC2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF004145
Actelion Java MolfileCreator 1.0

 33 37  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004145

>  <SMILES>
CC(C)n1nccc1[C@@H]1CN(C(=O)c2ccco2)C[C@]12CCCN(Cc1ccccn1)C2=O

$$$$
SWF004146
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004146

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(S(=O)(=O)c2ccc(C)cc2)C1

$$$$
SWF004147
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4729   -8.1174   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004147

>  <SMILES>
c1cc(CN2CCC3(CC2)OCCC3CCOCC2CC2)co1

$$$$
SWF004148
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1935   -4.8386   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004148

>  <SMILES>
c1cc(CN2CC3(C2)OCCC3CCOCC2CC2)cs1

$$$$
SWF004149
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 13 17  2  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004149

>  <SMILES>
Cc1ncc(C(=O)N2CCC3CC32C(=O)N2CCCC2)cn1

$$$$
SWF004150
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004150

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@@H]3[C@@H](CC2)OCCN3S(C)(=O)=O)o1

$$$$
SWF004151
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004151

>  <SMILES>
CCOCC1C(=O)N(CC)CC12CCN(C(=O)CC1(O)CCC1)CC2

$$$$
SWF004152
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   10.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004152

>  <SMILES>
CC(C)S(=O)(=O)N1CCC(C2CCCCN2Cc2ccc(Cl)cc2)CC1

$$$$
SWF004153
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  8 10  1  0  0  0  0
 13 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004153

>  <SMILES>
COC1(CC(=O)N2CC[C@H](O)[C@@H]2Cc2ccccc2)CCC1

$$$$
SWF004154
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.1444    2.5248   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 23 26  2  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004154

>  <SMILES>
Cc1ncccc1NC(=O)[C@@H]1COC[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]21

$$$$
SWF004155
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 12 10  1  1  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
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 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004155

>  <SMILES>
Cc1nc(C(=O)N2C[C@H]3Cn4c(-c5ccsc5)cnc4[C@H]3C2)cs1

$$$$
SWF004156
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF004156

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(Cc2ccco2)C1

$$$$
SWF004157
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 22 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004157

>  <SMILES>
Cc1noc(C)c1CN1CC2(CCN(C(=O)C3CC(O)C3)C2)CC1=O

$$$$
SWF004158
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.2258   -3.6684   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  7 11  2  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  6  8  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004158

>  <SMILES>
Cn1nccc1C(=O)N1CC2c3ccccc3S(=O)(=O)C2C1

$$$$
SWF004159
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 16 21  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
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 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004159

>  <SMILES>
CC(=O)N1CCC2(CC1)CN(Cc1ccc(C)cc1)S(=O)(=O)c1cccnc1O2

$$$$
SWF004160
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004160

>  <SMILES>
Cn1ccc(C(=O)N2CC3c4ccccc4S(=O)(=O)C3C2)n1

$$$$
SWF004161
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  4  9  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
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 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004161

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCCN(Cc2ccccc2)C1

$$$$
SWF004162
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004162

>  <SMILES>
CCS(=O)(=O)N1CCCC(C(=O)NC)(n2cccn2)C1

$$$$
SWF004163
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004163

>  <SMILES>
COc1ccc(-c2cnc3n2C[C@@H]2CN(C(=O)c4ccn(C)n4)C[C@@H]2C3)cc1

$$$$
SWF004164
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004164

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(Cc2cccc3ccccc23)C1

$$$$
SWF004165
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004165

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(S(C)(=O)=O)CC1

$$$$
SWF004166
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004166

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(S(C)(=O)=O)CC1

$$$$
SWF004167
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.4955   -5.0777   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004167

>  <SMILES>
Cc1nc(CN2C[C@@H]3CN(C(=O)CCF)C[C@@H]3C2=O)cs1

$$$$
SWF004168
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    3.6038    4.2416   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3250    3.0005   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3058   -0.0892   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6130    2.4642   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6074    2.6137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0469    3.3652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0441    3.4399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4780    4.3409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9146    5.1672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5  6  1  0  0  0  0
 12 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004168

>  <SMILES>
CCc1ccc(C(=O)N2CCN(C(=O)N(C)C)CC3(CNC(=O)C3)C2)cn1

$$$$
SWF004169
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7459   -4.2949   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3639   -4.2949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0549   -5.2459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0549   -5.2459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5549   -6.1120   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5549   -6.1120   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0549   -6.9780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004169

>  <SMILES>
O=C(c1cc2ccccc2[nH]1)N1CC2(CCC(CN3CCCCC3)CO2)C1

$$$$
SWF004170
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9863   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -4.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7  8  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004170

>  <SMILES>
COC1CC2(CCN(C(=O)CCc3ccccc3F)CC2)C1

$$$$
SWF004171
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7426    1.7509   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    3.1906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3825    3.3283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    3.1906   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6010    2.2638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3785    3.2387   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5206    1.8707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3207    2.4706   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2402    2.0775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2013    3.4634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0404    2.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0014    4.0632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9210    3.6702   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7211    4.2700   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004171

>  <SMILES>
CN1CCN(CC2CC[C@]3(COCCN(C(=O)C4CCOC4)C3)O2)CC1

$$$$
SWF004172
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    7.7832   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5333   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.6451   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5844   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1203    1.1591   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7023    1.8510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3904    3.3182   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1289    1.3874   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.1325    0.2727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.7108    2.7030   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004172

>  <SMILES>
CC1CC1C(=O)N1C[C@@H]2[C@@H](CNC(=O)C3CC(F)(F)C3)CO[C@@H]2C1

$$$$
SWF004173
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4764    1.7908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0587    2.4953   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 13 18  2  0  0  0  0
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 23 25  1  0  0  0  0
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 10 12  2  0  0  0  0
 14 18  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004173

>  <SMILES>
O=C(Nc1ccccc1)c1cnc2n1C(CNC(=O)C1CCOC1)CC2

$$$$
SWF004174
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  7 11  1  0  0  0  0
 16 17  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004174

>  <SMILES>
Cn1cnc2c1CC(CO)N(S(=O)(=O)c1ccccc1Cl)C2

$$$$
SWF004175
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004175

>  <SMILES>
CC(C)CN1CC2(COCCN(C(C)c3ccccc3)C2)CC1=O

$$$$
SWF004176
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  2  0  0  0  0
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 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004176

>  <SMILES>
O=C(N1CC2(CC(Oc3cccnc3)CS2)C1)C1(F)CC1

$$$$
SWF004177
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    5.6194   10.9395   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 17 20  1  6  0  0  0
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 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004177

>  <SMILES>
O=C(CC1CC1)NC[C@H]1CCC[C@]2(CCN(C(=O)c3cccc(Cl)n3)C2)O1

$$$$
SWF004178
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490   -1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  2  0  0  0  0
  9 10  1  0  0  0  0
 14 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004178

>  <SMILES>
CS(=O)(=O)N1CCOC2(CCCN(c3cnccn3)C2)C1

$$$$
SWF004179
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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 10 15  1  6  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
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 18 21  2  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004179

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2Cc3ncc(-c4ccccc4)n3C[C@@H]2C1

$$$$
SWF004180
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
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 26 28  2  0  0  0  0
  8  9  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004180

>  <SMILES>
Cc1ccccc1CC(=O)N1C[C@@H]2Cc3ncc(-c4ccccc4)n3C[C@@H]2C1

$$$$
SWF004181
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF004181

>  <SMILES>
Cc1cc(C)nc(N2CCOC3(COC(C(=O)NC4CCCCC4)C3)C2)n1

$$$$
SWF004182
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004182

>  <SMILES>
CC(C)N(C)CC1CCC2(COCCN(C(=O)c3cc[nH]n3)C2)O1

$$$$
SWF004183
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
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 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
 23 24  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004183

>  <SMILES>
Fc1ccc(CN2CCC(c3nnc4ncc(C5CC5)cn34)CC2)cc1F

$$$$
SWF004184
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004184

>  <SMILES>
Cc1nc(C(=O)N2CC3CC(C(=O)N4CCN(C)CC4)C(C2)O3)cs1

$$$$
SWF004185
Actelion Java MolfileCreator 1.0

 22 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 17 15  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  6  0  0  0
 20 22  1  0  0  0  0
  7  9  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004185

>  <SMILES>
O=C1C2CN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CC2CCN1CC1CC1

$$$$
SWF004186
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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   15.8716   -2.1510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  2  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 14 13  1  1  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004186

>  <SMILES>
CC(C)CCN1CCCC2(CC(C(=O)NC3CC(F)(F)C3)=NO2)C1

$$$$
SWF004187
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 14 18  1  0  0  0  0
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 17 20  1  6  0  0  0
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 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004187

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCO[C@]2(CCC[C@@H]2COCC2CC2)C1

$$$$
SWF004188
Actelion Java MolfileCreator 1.0

 22 26  0  0  1  0  0  0  0  0999 V2000
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004188

>  <SMILES>
O=C(NC1CCC1)C1CC12CCN(C(=O)C1[C@H]3COC[C@@H]13)C2

$$$$
SWF004189
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004189

>  <SMILES>
CN1CCC2(CN(C(=O)Cc3ccn(C)n3)CC(F)(F)C2)C1=O

$$$$
SWF004190
Actelion Java MolfileCreator 1.0

 29 34  0  0  1  0  0  0  0  0999 V2000
    2.6295    0.0146   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  1  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  8  9  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
 19 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004190

>  <SMILES>
O=C(NC12CC3CC(CC(C3)C1)C2)N1C[C@H]2CCN(c3ncccn3)CC[C@H]2C1

$$$$
SWF004191
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  8  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004191

>  <SMILES>
O=C(N1CCCC2(COCCN(c3ncccn3)C2)C1)C1(F)CCC1

$$$$
SWF004192
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 13 10  1  6  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
  9 11  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004192

>  <SMILES>
Cn1ccc(C(=O)N2CCC3(Cc4ncc(-c5cccs5)n4C3)C2)n1

$$$$
SWF004193
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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  8  9  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004193

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H]2[C@H]1CCN2S(=O)(=O)C1CC1

$$$$
SWF004194
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 24 26  2  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004194

>  <SMILES>
CCc1nc2c(c(=O)n1CCOC)CCN(C(=O)c1ccccc1)CC2

$$$$
SWF004195
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.5307    2.2242   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004195

>  <SMILES>
N#Cc1ccc(OC[C@]23COC[C@H]2CN(C(=O)C2(F)CC2)C3)nc1

$$$$
SWF004196
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  2  0  0  0  0
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 16 20  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004196

>  <SMILES>
O=C(Cc1ccccc1)N1CCOC2(C1)C(=O)NCC2c1ccccc1

$$$$
SWF004197
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
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  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 14 10  1  1  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004197

>  <SMILES>
O=C(NC1CCC1)C1C[C@@H]2CCN(C(=O)c3cc[nH]n3)C[C@@H]2O1

$$$$
SWF004198
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004198

>  <SMILES>
COC[C@@H]1CCC[C@@]12CN(C(=O)CCc1cncnc1)CCO2

$$$$
SWF004199
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.9955   -5.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 13  1  1  0  0  0
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 16 18  2  0  0  0  0
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  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004199

>  <SMILES>
Cn1c(C(=O)N2C[C@H]3CN(CC4CC4)C(=O)[C@H]3C2)cccc1=O

$$$$
SWF004200
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    7.7331   -2.1783   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004200

>  <SMILES>
CN1CCN(C(=O)C2CC3CN(C(=O)CCc4cncnc4)CC2O3)CC1

$$$$
SWF004201
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.1566    0.6895   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5095    1.6706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7791    2.4334   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004201

>  <SMILES>
O=C(N1C2CCC1CN(Cc1cccnc1)C2)C1(F)CCC1

$$$$
SWF004202
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004202

>  <SMILES>
O=C1CC2(CCN1Cc1ccncc1)CCN(C(=O)c1ccccc1)CC2

$$$$
SWF004203
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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  5 10  1  0  0  0  0
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  7 12  1  6  0  0  0
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  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 13 18  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004203

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1CCOC2CCC1C2OCc1ccncc1

$$$$
SWF004204
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004204

>  <SMILES>
O=C(NC1CCC1)C1=NOC2(CCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CC2)C1

$$$$
SWF004205
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004205

>  <SMILES>
CO[C@@H]1CCN(C(=O)C2[C@H]3COC[C@@H]23)C[C@H]1Cc1ccccc1

$$$$
SWF004206
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004206

>  <SMILES>
CC1(C(=O)N2CCC3(CC(OCC4CC4)CO3)C2)CC=CCC1

$$$$
SWF004207
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 17 18  2  0  0  0  0
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 22 24  1  0  0  0  0
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 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004207

>  <SMILES>
COc1cccc(CN2CCC3(CCC(=O)N3CC3CC3)CC2)c1

$$$$
SWF004208
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
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 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004208

>  <SMILES>
CC1(C(=O)N2CCCC3(COCCN(c4nccs4)C3)C2)CC=CCC1

$$$$
SWF004209
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  6  0  0  0
  9 14  2  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  7  8  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004209

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1CCOCC1c1nccc(N2CCOCC2)n1

$$$$
SWF004210
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004210

>  <SMILES>
O=C(Cn1ccccc1=O)N1CC2CC(CN(Cc3cccnc3)C2)C1

$$$$
SWF004211
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
 11  7  1  1  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004211

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1CC[C@H]2C[C@@H](C(=O)N3CCCCO3)O[C@@H]2C1

$$$$
SWF004212
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 17 20  2  0  0  0  0
 18 21  1  1  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004212

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)NC(=O)[C@@H]2CN(CC4CC4)C[C@@H]23)cs1

$$$$
SWF004213
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1988   -4.5816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0969   -6.1087   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5887   -5.9519   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8418   -3.8385   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4893   -8.2260   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004213

>  <SMILES>
CCS(=O)(=O)NC1COC2(CCCN(c3ncccc3C(=O)N3CCCC3)C2)C1

$$$$
SWF004214
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2321   -6.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7321   -5.6369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  1  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004214

>  <SMILES>
CC1CC(N(C)C(=O)c2nc3c(o2)CCN(C(C)c2ccccc2)C3)C1

$$$$
SWF004215
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   -2.6123   -8.8496   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1674   -7.6397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3910   -5.5609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9883   -6.1504   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1885   -5.2507   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6219   -5.6928   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1067   -7.1123   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4853   -4.4663   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004215

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(c4ccc(F)cc4)C3)C2)c1

$$$$
SWF004216
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004216

>  <SMILES>
O=S(=O)(C1CC1)N1CCOC2(CCCN(c3cnccn3)C2)C1

$$$$
SWF004217
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.1207   -3.3555   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 14 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004217

>  <SMILES>
CC1CC(C(=O)N2Cc3ncnn3CC(C(=O)N3CCN(C)CC3)C2)C1

$$$$
SWF004218
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.7734   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097   -1.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3834   -3.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004218

>  <SMILES>
CCCN1C[C@H]2C(=O)NC3(CCN(C(=O)COc4ccccc4)CC3)[C@H]2C1

$$$$
SWF004219
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6456   -1.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3147   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8147   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2215   -3.6160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1996   -3.8239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7215   -4.4820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3041   -4.8184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3906   -5.2251   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004219

>  <SMILES>
O=C(N1CCC2(CC1)CC(N1CCCC1)CO2)C1(F)CCC1

$$$$
SWF004220
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9080   -3.4820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3092   -2.6730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6511   -4.1511   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5172   -3.6511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4307   -4.0579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004220

>  <SMILES>
Cc1cc(C(=O)N2CCn3cc(CN4CCCC4)nc3C2)no1

$$$$
SWF004221
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    2.8923    6.2014   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5834    5.4786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3062    6.1696   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2745    4.7558   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8606    4.7875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9007    5.0679   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0977    3.8160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1779    4.3769   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3749    3.1250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4150    3.4054   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6120    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8396    1.5183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5901    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8545    0.5185   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0374    1.0512   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6171    0.1438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0934   -2.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004221

>  <SMILES>
O=C1CCC2(CCCN(c3cc(C(F)(F)F)ncn3)CC2)N1CC1CCCCC1

$$$$
SWF004222
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.5264    3.4679   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9332    2.5544   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9277    2.4499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7521    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3344    1.5363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7466    0.7273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1534   -0.1862   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1479   -0.2908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004222

>  <SMILES>
CNC(=O)C1CC2(CO1)CN(Cc1cc(OC)ccc1F)CCO2

$$$$
SWF004223
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 15 13  1  6  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004223

>  <SMILES>
COCCN1CCCCC1C1CCN(C(=O)c2ccccc2)CC1

$$$$
SWF004224
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7629    0.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2162   -2.5143   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5865   -1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004224

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1C[C@H](OCc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF004225
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8073    2.5340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004225

>  <SMILES>
CN1C[C@@H](COCC2CC2)[C@]2(CCN(C(=O)C3CC(O)C3)C2)C1

$$$$
SWF004226
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 17 20  2  0  0  0  0
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 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 19 24  1  0  0  0  0
 21 25  2  0  0  0  0
 21 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
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 13 14  1  0  0  0  0
 19 23  1  0  0  0  0
 20 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004226

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)CN(C)Cc2nnc(-c4ccc(F)cc4)n23)cs1

$$$$
SWF004227
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004227

>  <SMILES>
CNC(=O)C1CC2(CO1)CN(Cc1cnc(OC)c(C)c1)CCO2

$$$$
SWF004228
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004228

>  <SMILES>
O=S(=O)(NCCC1CN(CC2CCCC2)Cc2ccnn21)C1CC1

$$$$
SWF004229
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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    1.3117   -1.5146   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0855   -1.0051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 20 23  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004229

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2ccccc2)C1

$$$$
SWF004230
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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   -4.2221   -1.9463   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004230

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(Cc2cccs2)CC1

$$$$
SWF004231
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004231

>  <SMILES>
CC1(C(=O)NC2CC3(CCN(Cc4ccc(F)cc4F)CC3)C2)CC1

$$$$
SWF004232
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 13 14  1  0  0  0  0
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 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
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 17 19  1  0  0  0  0
 20 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004232

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CC1(CC2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF004233
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004233

>  <SMILES>
COc1ccc(CN2CCOC3(COC(C(=O)N(C)C)C3)C2)cc1

$$$$
SWF004234
Actelion Java MolfileCreator 1.0

 30 32  0  0  0  0  0  0  0  0999 V2000
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 17 21  2  0  0  0  0
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 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 15 18  1  0  0  0  0
 20 23  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004234

>  <SMILES>
CC(C)CN1CCC2(CCCN(C(=O)c3ccccc3)C2CNC(=O)N(C)C)CC1

$$$$
SWF004235
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004235

>  <SMILES>
O=C(CC1CCOCC1)NC1CC2(CCN(Cc3cccnc3)CC2)C1

$$$$
SWF004236
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  8  1  0  0  0  0
  6  7  1  0  0  0  0
 15 14  1  1  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004236

>  <SMILES>
O=C(C1=NOC2(CCCN(Cc3ccccc3)C2)C1)N1CC(F)(C2CC2)C1

$$$$
SWF004237
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  6  0  0  0
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 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
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 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004237

>  <SMILES>
O=C(c1ccoc1)N1CCCC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF004238
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004238

>  <SMILES>
COCC12CCCOC1CCN(C(=O)C1(C)CC=CCC1)C2

$$$$
SWF004239
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF004239

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(Cc2ccoc2)C3)n1

$$$$
SWF004240
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  9 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 25  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004240

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(Cc2cccc(C)c2)CC1

$$$$
SWF004241
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004241

>  <SMILES>
c1cnc(NC2COC3(CCCN(Cc4ccsc4)C3)C2)nc1

$$$$
SWF004242
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.6218    2.2705   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 22 24  2  0  0  0  0
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 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004242

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)Cc2ccccn2)C1

$$$$
SWF004243
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004243

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)C3CC3C)C2)CN1CC1CC1

$$$$
SWF004244
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  7 10  2  0  0  0  0
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 10 13  1  0  0  0  0
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 25 27  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004244

>  <SMILES>
O=C(Cc1ccc(O)cc1)N1CCC2(CC1)COC(CN1CCC(O)C1)C2

$$$$
SWF004245
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  7  1  0  0  0  0
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 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004245

>  <SMILES>
O=C(C1CCC1)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF004246
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.4095   -7.1265   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2948   -6.1228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6066   -4.6555   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4047   -8.0129   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
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 10  6  1  1  0  0  0
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 10 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 15 20  1  1  0  0  0
 16 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 15 19  1  0  0  0  0
 17 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004246

>  <SMILES>
COCC[C@H]1CO[C@H]2CN(C(=O)c3cn(C)c4ccccc34)C[C@@H]12

$$$$
SWF004247
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
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 10 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004247

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCn3cc(CC(=O)N(C)C)nc3C2C)cc1

$$$$
SWF004248
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5 10  1  0  0  0  0
 11  7  1  6  0  0  0
 12  8  1  1  0  0  0
 13  9  1  6  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  1  6  0  0  0
 23 24  2  0  0  0  0
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 25 26  1  0  0  0  0
  6 10  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004248

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)C34C[C@H]5C[C@@H](C3)C[C@@H](C4)C5)C2)CN1C

$$$$
SWF004249
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004249

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCN(C(C)C)CC1

$$$$
SWF004250
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    1.1221   -1.2999   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9298   -0.3185   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6812    0.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 13 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF004250

>  <SMILES>
COC1CCOC2(C1)CN(C(=O)C13C[C@H]4C[C@@H](C1)C[C@@H](C3)C4)C2

$$$$
SWF004251
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004251

>  <SMILES>
CC1CC1C(=O)N1C[C@@H]2[C@H](CNC(=O)c3ccccc3)CO[C@@H]2C1

$$$$
SWF004252
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.6605   -6.6478   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.5037   -5.1560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004252

>  <SMILES>
O=C(NCCC1CCOC12CN(Cc1cccs1)C2)C1CC(F)(F)C1

$$$$
SWF004253
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 22  1  0  0  0  0
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 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004253

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC3OCCN(C(C)C)C3C2)n[nH]1

$$$$
SWF004254
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004254

>  <SMILES>
COc1ccc(C(=O)N2CC3(CC(CO)CN3C)C2)cc1Cl

$$$$
SWF004255
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 13 15  1  6  0  0  0
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M  END
>  <HTSID>
SWF004255

>  <SMILES>
CC1CC1C(=O)N1C[C@@H]2[C@@H](CNC(=O)c3ccsc3)CO[C@@H]2C1

$$$$
SWF004256
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 23 26  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004256

>  <SMILES>
Cc1cccc(CN2CCC(Nc3ccnn3C)(C(=O)N(C)C)CC2)c1

$$$$
SWF004257
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 20  2  0  0  0  0
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 20 24  1  0  0  0  0
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 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF004257

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(C(=O)C2CC(F)C2)CC1

$$$$
SWF004258
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
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 13 15  1  6  0  0  0
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M  END
>  <HTSID>
SWF004258

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)C3CCC3)C[C@H]12)c1ccsc1

$$$$
SWF004259
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
  3  4  1  0  0  0  0
 12 13  2  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004259

>  <SMILES>
O=C([C@@H]1C[C@H]1F)N1CCc2ncnc(-c3ccncc3)c2CC1

$$$$
SWF004260
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 22 23  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004260

>  <SMILES>
C=CCN1CCCC12CCN(C(=O)c1ccc(CC)nc1)CC2

$$$$
SWF004261
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1280   -2.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
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 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004261

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(C(=O)C2CCC2)C3)n1

$$$$
SWF004262
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.1004   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3139   -2.9214   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4519   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1803    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7740    1.7996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4005    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0106    4.2267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004262

>  <SMILES>
COCCN1CCC2(CN(C(=O)c3ccnnc3)CC(F)(F)C2)C1=O

$$$$
SWF004263
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7  5  1  6  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004263

>  <SMILES>
CN1CCC2(CN(C(=O)c3ccncc3)CC(F)(F)C2)C1=O

$$$$
SWF004264
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4952  -10.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 20 25  1  0  0  0  0
 21 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 24 26  2  0  0  0  0
M  END
>  <HTSID>
SWF004264

>  <SMILES>
CN(C)C(=O)C1(Nc2ccnn2C)CCN(Cc2ccc(Cl)cc2)CC1

$$$$
SWF004265
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.3240   -5.5808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9505   -6.6375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004265

>  <SMILES>
CN(C)C1COC2(CCN(C(=O)C3CC(F)(F)C3)CC2)C1

$$$$
SWF004266
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    1.6115    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6257   -0.7580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9385    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
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 19 22  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004266

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCCN(C(=O)C(C)(C)C)C1

$$$$
SWF004267
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2854    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1046    0.4506   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.8910    2.5524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  6  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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  7  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004267

>  <SMILES>
CCS(=O)(=O)N1CC2(CC(OCc3ccncc3)CS2)C1

$$$$
SWF004268
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.6209    2.2697   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9313    3.0263   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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 24 25  1  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004268

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)Cc2ccc(C)cc2)C1

$$$$
SWF004269
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004269

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)COc2ccccc2)C1

$$$$
SWF004270
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
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 16 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004270

>  <SMILES>
O=C(C1CC(F)C1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF004271
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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  7  9  1  0  0  0  0
 12 13  1  0  0  0  0
M  END
>  <HTSID>
SWF004271

>  <SMILES>
CCS(=O)(=O)N1CC2(CC(OCC(=O)N(C)C)CS2)C1

$$$$
SWF004272
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.6209    2.2697   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9313    3.0263   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  2  0  0  0  0
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 13 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004272

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)Cc2ccccc2C)C1

$$$$
SWF004273
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004273

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(Cc2cccnc2)CC1

$$$$
SWF004274
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.9273    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004274

>  <SMILES>
O=C(CC1CC1)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF004275
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    8.8745    1.5288   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8627    0.7566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5556   -0.6155   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 23 26  2  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004275

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)COc2ccccc2C)C1

$$$$
SWF004276
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.6218    2.2705   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9326    3.0273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004276

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)Cc2ccccc2)C1

$$$$
SWF004277
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004277

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(C(=O)Cc2ccc(C)cc2)CC1

$$$$
SWF004278
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.9273    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9055    1.9095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7364    0.3004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4055    1.0435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4000    0.9390   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9878    1.7480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004278

>  <SMILES>
O=C(CC1CC1)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF004279
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004279

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CCCCN3C)CC2)cn1

$$$$
SWF004280
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
M  END
>  <HTSID>
SWF004280

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(C(=O)C(C)C)CC1

$$$$
SWF004281
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004281

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(OCC3CCCC3)CS2)C1

$$$$
SWF004282
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004282

>  <SMILES>
O=C(N1C[C@H](Oc2cccnc2)[C@H]2OCCC[C@H]21)C1(F)CC1

$$$$
SWF004283
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004283

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF004284
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.4738   -4.5556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004284

>  <SMILES>
COCCc1cnc2n1CCN(C(=O)c1occc1C)C2C

$$$$
SWF004285
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004285

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(Cc2ccc(C)s2)C3)n1

$$$$
SWF004286
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004286

>  <SMILES>
CN1CCC(COCc2ccccn2)CC12CN(S(=O)(=O)c1cccnc1)C2

$$$$
SWF004287
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004287

>  <SMILES>
COCC1CN(Cc2csc(C)n2)CC12CCN(C(C)C)CC2

$$$$
SWF004288
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF004288

>  <SMILES>
CNC(=O)C1=NOC2(CCCN(Cc3cnn(C(C)C)c3)C2)C1

$$$$
SWF004289
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
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 12 15  2  0  0  0  0
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 14 19  1  0  0  0  0
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 17 22  2  0  0  0  0
 18 23  1  0  0  0  0
 18 24  2  0  0  0  0
 19 25  1  0  0  0  0
 20 26  2  0  0  0  0
 20 27  1  0  0  0  0
  6  9  1  0  0  0  0
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 19 23  2  0  0  0  0
 21 26  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004289

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(c2cc(C)nc4ncnn24)C3)n1

$$$$
SWF004290
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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 11 10  1  1  0  0  0
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M  END
>  <HTSID>
SWF004290

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(c3cc(C(F)(F)F)ncn3)CC[C@H]21)NC1CS(=O)(=O)C1

$$$$
SWF004291
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 18 19  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004291

>  <SMILES>
c1coc(CN2CC3(CC(OCC4CCOCC4)CS3)C2)c1

$$$$
SWF004292
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.8006   -6.8243   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004292

>  <SMILES>
Cc1nc(C(=O)N2CCc3ncc(CN(C)C)n3CC2)cs1

$$$$
SWF004293
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004293

>  <SMILES>
C1CC(CN2CC3(CC(OCC4CCOCC4)CS3)C2)C1

$$$$
SWF004294
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  8  7  1  1  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004294

>  <SMILES>
C=CCN1C(=O)CO[C@@H]2CN(C(=O)c3ccc(CC)nc3)C[C@H]21

$$$$
SWF004295
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.6721    0.2725   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004295

>  <SMILES>
C=CCO[C@@H]1CCN(C(=O)C2CC(C)C2)[C@H]1Cc1ccccc1

$$$$
SWF004296
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.6594    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004296

>  <SMILES>
CCOCC(=O)N1CC2(CC(OCc3cccc(C)n3)CS2)C1

$$$$
SWF004297
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004297

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(C(=O)C2CCOC2)C3)n1

$$$$
SWF004298
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  1  1  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004298

>  <SMILES>
O=C(CC1CN(S(=O)(=O)c2cccnc2)Cc2ccnn21)NCc1ccccn1

$$$$
SWF004299
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9261   -0.4984   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1930    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004299

>  <SMILES>
CS(=O)(=O)N1CCOCC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF004300
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
 19 24  2  0  0  0  0
 21 25  1  0  0  0  0
 21 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004300

>  <SMILES>
COc1ccc(C(=O)N2CCC(C(=O)N(C)C)(n3cccn3)CC2)cc1

$$$$
SWF004301
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 26 29  1  0  0  0  0
  6  7  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <HTSID>
SWF004301

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCOCC2(CCC(Cn3ncccc3=O)O2)C1

$$$$
SWF004302
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.7912   -4.0125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7967   -3.9079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  6  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004302

>  <SMILES>
CN1CC(CO)CC12CN(C(=O)c1ccc3ccccc3c1)C2

$$$$
SWF004303
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.8281    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2961   -1.6353   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
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  8 14  1  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 14  2  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004303

>  <SMILES>
Cn1nccc1C(=O)N1CC[C@H]2CN(Cc3cccnc3)C[C@H]21

$$$$
SWF004304
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.4738   -4.5556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4957   -4.3477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF004304

>  <SMILES>
COCCc1cnc2n1CCN(C(=O)c1ccc(C)nc1)C2C

$$$$
SWF004305
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.5772    4.5284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5283    4.2194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7077    3.0042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004305

>  <SMILES>
COCc1nnc2n1CCN(C(=O)c1cncc(C)c1)C(C)C2

$$$$
SWF004306
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004306

>  <SMILES>
CCN1CCC2(CN(C(=O)c3ccn(C)n3)CC(F)(F)C2)C1=O

$$$$
SWF004307
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.9462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004307

>  <SMILES>
Cc1ccccc1CC(=O)N1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF004308
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 24  1  0  0  0  0
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 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004308

>  <SMILES>
Fc1cccc(CN2CC3(CC(OCC4CCOCC4)CS3)C2)c1

$$$$
SWF004309
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1937    2.7602   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 14 20  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004309

>  <SMILES>
COc1ncccc1C(=O)N1Cc2ccnn2CCC1CO

$$$$
SWF004310
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004310

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)Cc2ccccn2)CC1

$$$$
SWF004311
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.5841    0.6912   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5869    1.8038   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1234    3.2305   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0543    1.4919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6966    3.6941   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0051    4.4442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8975   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5178    2.9186   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  2  0  0  0  0
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 16 17  1  0  0  0  0
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  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004311

>  <SMILES>
O=C(CC1CCOCC1)N1CCC2CC21C(=O)N1CCCC1

$$$$
SWF004312
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 20 22  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004312

>  <SMILES>
CCc1ccc(C(=O)N2CCc3nc(C(=O)N(C)C)sc3CC2)cn1

$$$$
SWF004313
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.5471   -4.4801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3392   -3.5019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004313

>  <SMILES>
CC(=O)N1CCC2(CC1)OCCC2CCOc1cccnc1

$$$$
SWF004314
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.5499   -6.3666   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.2408   -5.4155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2701   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004314

>  <SMILES>
CN(C)CCNC(=O)C1CCc2[nH]nc(-c3cccc(F)c3)c2C1

$$$$
SWF004315
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 18 20  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004315

>  <SMILES>
Cn1cc(-c2nnn3c2COC(CNC(=O)c2cc(C4CC4)on2)C3)cn1

$$$$
SWF004316
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 17 15  1  1  0  0  0
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M  END
>  <HTSID>
SWF004316

>  <SMILES>
O=C(NC1CCC1)C1C[C@@H]2CCN(C(=O)Cc3ccc(F)cn3)C[C@@H]2O1

$$$$
SWF004317
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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M  END
>  <HTSID>
SWF004317

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@]3(C2)C(=O)NC[C@H]3COc2cccnc2)cn1

$$$$
SWF004318
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004318

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CCCC2(CC(n3ccnc3)CO2)C1

$$$$
SWF004319
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004319

>  <SMILES>
O=C(NC1CCc2onc(CN3CCCC3)c2C1)c1ccccc1

$$$$
SWF004320
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4990    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4746    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004320

>  <SMILES>
CN(C)CC1CCC2(COCCN(C(=O)CCc3cncnc3)C2)O1

$$$$
SWF004321
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0395   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4407   -3.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0701   -4.2048   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 15 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004321

>  <SMILES>
O=C(c1cncnc1)N1CC2(CC(NC3CCC3)CS2)C1

$$$$
SWF004322
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
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  8 12  2  0  0  0  0
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 10 15  1  1  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004322

>  <SMILES>
O=C(NC1CCC1)[C@@H]1CN(C(=O)c2cc[nH]n2)C[C@H]2OCC[C@H]21

$$$$
SWF004323
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7871   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4562   -2.7601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1472   -1.8090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1035   -2.2248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7350   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0980   -2.3294   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8956   -1.2467   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -0.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4829   -1.2079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
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 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
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 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004323

>  <SMILES>
Cn1ccc(NC(=O)c2ncn3c2CCC(C(=O)NCC2CC2)C3)n1

$$$$
SWF004324
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6286    2.4068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2163    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
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 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 25 26  1  0  0  0  0
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 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004324

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]2N1S(C)(=O)=O

$$$$
SWF004325
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.5561   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2449   -2.2711   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9337   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8674   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5561   -4.5422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4898   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3112   -1.5141   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4898   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0036   -0.0187   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3280    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0851   -1.0047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004325

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2ccccc2C)C1

$$$$
SWF004326
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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    2.3763    4.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  4  6  1  0  0  0  0
 14 17  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004326

>  <SMILES>
Cc1nc(C(=O)N2CCCC3(CCN(C)CC3)C2CNC(=O)C(C)C)cs1

$$$$
SWF004327
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2583    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.1244    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004327

>  <SMILES>
COCCN1CCCC2(CCN(C(=O)Cc3ccc(C#N)cc3)CC2)C1=O

$$$$
SWF004328
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5990    1.7658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004328

>  <SMILES>
CCOCCC1CCOC12CCN(Cc1ccc(C)cc1)CC2

$$$$
SWF004329
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004329

>  <SMILES>
O=C(Cc1cccc(F)c1)N1CCC2(CCCNC2=O)CC1

$$$$
SWF004330
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004330

>  <SMILES>
O=C(c1ccccc1)N1CC[C@]2(C1)C[C@@H](NS(=O)(=O)C1CC1)C2

$$$$
SWF004331
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6939   -2.3647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8279   -3.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  6  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004331

>  <SMILES>
O=C(C1=COCC1)N1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF004332
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004332

>  <SMILES>
Cc1cccc(CN2Cc3ccnn3C(CNS(C)(=O)=O)C2)c1

$$$$
SWF004333
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004333

>  <SMILES>
CC(C)CC(=O)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF004334
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004334

>  <SMILES>
CC(C)CC(=O)N1CC2(CC(Oc3cnccn3)CCO2)C1

$$$$
SWF004335
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6432   -4.4487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004335

>  <SMILES>
Cc1cc(C(=O)N2C[C@@H]3OCCN(Cc4cccnc4)[C@H]3C2)n(C)n1

$$$$
SWF004336
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.4160   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 13 15  1  1  0  0  0
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 22 24  2  0  0  0  0
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  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004336

>  <SMILES>
O=C(C1CCC1)N1C[C@H]2[C@@H](CCOCc3ccccn3)CO[C@H]2C1

$$$$
SWF004337
Actelion Java MolfileCreator 1.0

 18 20  0  0  0  0  0  0  0  0999 V2000
    5.8147    0.0296   -0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004337

>  <SMILES>
BrCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF004338
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004338

>  <SMILES>
CC(C)CN1CC2(COCCN(Cc3ccccc3)C2)CC1=O

$$$$
SWF004339
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    8.4160   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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  8 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  1  0  0  0
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 25 27  2  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004339

>  <SMILES>
O=C(c1cccc(O)c1)N1C[C@H]2[C@@H](CCOCc3ccccn3)CO[C@H]2C1

$$$$
SWF004340
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.4095   -7.1265   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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  9 10  1  0  0  0  0
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M  END
>  <HTSID>
SWF004340

>  <SMILES>
COCC[C@H]1CO[C@H]2CN(C(=O)c3cc4ccccc4[nH]3)C[C@@H]12

$$$$
SWF004341
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004341

>  <SMILES>
Cc1ccccc1CCC(=O)N1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF004342
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004342

>  <SMILES>
Cc1ccccc1CC(=O)N1CCCC(C(=O)N(C)C)(n2cccn2)C1

$$$$
SWF004343
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004343

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(C(C)C)C3)C2)c1

$$$$
SWF004344
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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 10  7  1  6  0  0  0
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M  END
>  <HTSID>
SWF004344

>  <SMILES>
CN(Cc1ccccn1)C(=O)[C@H]1CC[C@@H]2[C@@H](CCN2C(=O)C2CC(O)C2)O1

$$$$
SWF004345
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004345

>  <SMILES>
CN1C(=O)C2(CCOCC2)c2cc(NC(=O)Cc3ccn(C)n3)ccc21

$$$$
SWF004346
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004346

>  <SMILES>
O=C(c1cc[nH]c1)N1CC[C@H]2CC(C(=O)N3CCCC3)O[C@H]2C1

$$$$
SWF004347
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.0158    3.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004347

>  <SMILES>
N#CC1(C(=O)N2CCC3(CC3C(=O)NC3CCC3)C2)CCCC1

$$$$
SWF004348
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004348

>  <SMILES>
Cc1c(F)cccc1C(=O)N1CCc2ncc(-c3ccccc3)n2CC1

$$$$
SWF004349
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004349

>  <SMILES>
CCOCC1CCS(=O)(=O)C12CN(Cc1cc(C)ccc1C)C2

$$$$
SWF004350
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004350

>  <SMILES>
CC(C)N1CCc2oc(C(=O)N3CCC(F)(F)CC3)nc2C1

$$$$
SWF004351
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004351

>  <SMILES>
Cc1ccccc1CN1CCc2oc(C(=O)N3CCCC(C)C3)nc2C1

$$$$
SWF004352
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.0535   -0.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3035    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0535    2.0490   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   12.5535    2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9218    1.9635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9218   -0.4635   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.3035    3.3481   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004352

>  <SMILES>
CC(C)CN1CCc2oc(C(=O)N3CCCC(C)C3)nc2C1

$$$$
SWF004353
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004353

>  <SMILES>
O=C(C1CCCC1)N1CCc2ncc(-c3ccccc3)n2CC1

$$$$
SWF004354
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
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 17 20  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004354

>  <SMILES>
CCOc1ccc(C(=O)N2CCc3ncc(-c4ccccc4OC)n3CC2)cc1

$$$$
SWF004355
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.4206    5.5664   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.8878    5.8783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8915    4.7636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.3587    5.0755   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF004355

>  <SMILES>
O=C(NCC1CC1)c1noc2c1CC(NCc1ccccc1Cl)CC2

$$$$
SWF004356
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004356

>  <SMILES>
COc1ccccc1-c1cnc2n1CCN(C(=O)c1ccnnc1)CC2

$$$$
SWF004357
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004357

>  <SMILES>
O=C1NC2(CCN(C(=O)c3cccs3)CC2)[C@H]2CN(CC3CC3)C[C@@H]12

$$$$
SWF004358
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 17 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004358

>  <SMILES>
O=C(CC1CCCCC1)N1CCc2ncc(-c3ccccc3)n2CC1

$$$$
SWF004359
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004359

>  <SMILES>
O=C(c1cc[nH]n1)N1C[C@H](Oc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF004360
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 15 17  2  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004360

>  <SMILES>
CNC(=O)C1(Nc2ccnn2C)CCN(Cc2ccco2)CC1

$$$$
SWF004361
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <HTSID>
SWF004361

>  <SMILES>
CC(C)C(=O)N1CCC(Nc2ccnn2C)(C(=O)N(C)C)CC1

$$$$
SWF004362
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004362

>  <SMILES>
c1ccc(CN2CC3(C2)OCCC3CCOCC2CC2)cc1

$$$$
SWF004363
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  9  1  0  0  0  0
 10 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004363

>  <SMILES>
CCc1oncc1C(=O)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF004364
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
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M  END
>  <HTSID>
SWF004364

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CCC1(CC2)CCN(C(=O)Cn2ccccc2=O)C1

$$$$
SWF004365
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004365

>  <SMILES>
CC1(C(=O)N2CC[C@@]3(C[C@H](Nc4ccccn4)CCO3)C2)CC=CCC1

$$$$
SWF004366
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004366

>  <SMILES>
O=C(N1CC2(CC(OCc3ccccn3)CS2)C1)C1(F)CC1

$$$$
SWF004367
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004367

>  <SMILES>
C[C@@H]1CN(C(=O)Cc2ccc(C#N)cc2)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF004368
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   15.2370    3.5471   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.9380    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3399    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    0.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    5.0471   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  2  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004368

>  <SMILES>
CN(C)C(=O)c1nc2c(s1)CCN(C(=O)c1cccc(Cl)n1)CC2

$$$$
SWF004369
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004369

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF004370
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004370

>  <SMILES>
Cc1cccnc1C(=O)N1C[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF004371
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004371

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)C2CCOCC2)C1

$$$$
SWF004372
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8986   -2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8986   -2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3986   -1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3986   -3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004372

>  <SMILES>
COCCCN1CCO[C@H]2CN(C(=O)c3cn(C)cn3)C[C@@H]21

$$$$
SWF004373
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
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 20 22  2  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004373

>  <SMILES>
CS(=O)(=O)NCC1CCC2(CN(Cc3ccccn3)C2)OC1

$$$$
SWF004374
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  7  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 24 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004374

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1C[C@@H]2CCN(C(=O)CC3(O)CCC3)C[C@@H]2O1

$$$$
SWF004375
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    9.2574   -4.2460   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7901   -4.5578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3266   -5.9845   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7864   -3.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8593   -6.2963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3191   -3.7550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8556   -5.1816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3154   -2.6402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -2.9544   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7790   -1.2136   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8972   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004375

>  <SMILES>
O=C(c1ccnc(F)c1)N1CCC2CC21C(=O)NC1CCC1

$$$$
SWF004376
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 17  2  0  0  0  0
 14 18  1  1  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  3  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004376

>  <SMILES>
CO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)Cc1ccc(C#N)cc1

$$$$
SWF004377
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.3131    3.9724   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.6250    2.5052   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5103    1.5015   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0516    2.0417   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9309    0.0617   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1223    2.0703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3634    0.5744   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1663    3.0454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.4106   -0.1841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.5929    2.5818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF004377

>  <SMILES>
CCOCc1nnc2n1CCN(C(=O)c1cc(C)nc(C)c1)C(C)C2

$$$$
SWF004378
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5196    2.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5817    3.2040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9820    3.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0839    5.2687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9451    7.8069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2289    6.5601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
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 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004378

>  <SMILES>
CN(C)C(=O)COC1CSC2(C1)CN(C(=O)C1CCC1)C2

$$$$
SWF004379
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5779    2.0698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2654    5.0218   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8 10  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004379

>  <SMILES>
O=C(CCc1ccc[nH]1)N1C[C@H](Oc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF004380
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8481   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0827   -2.8198   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3919    0.7372   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  1  0  0  0
  9 15  1  0  0  0  0
 10 16  1  6  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 10  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004380

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@H](Oc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF004381
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   10.0409   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.4428   -3.5471   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
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 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004381

>  <SMILES>
Cn1cncc1CN1C[C@H]2CCN(c3ncccn3)CC[C@H]2C1

$$$$
SWF004382
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004382

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(CC1)CC(N1CCCC1)C2

$$$$
SWF004383
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004383

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCC2(CC1)C(=O)NCCN2CC1CC1

$$$$
SWF004384
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004384

>  <SMILES>
Cn1cnc(C(=O)N2CC3(CC(N4CCOCC4)CS3)C2)c1

$$$$
SWF004385
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004385

>  <SMILES>
N#CC1(C(=O)N2CCC3(CC2)CCN(c2cccnc2)C3=O)CCCC1

$$$$
SWF004386
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    5.2258   -3.6684   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 14  1  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF004386

>  <SMILES>
O=C(c1ccco1)N1CC2c3ccccc3S(=O)(=O)C2C1

$$$$
SWF004387
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004387

>  <SMILES>
O=S(=O)(c1ccc2c(c1)OCCO2)N1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF004388
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 12 11  1  1  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004388

>  <SMILES>
CC(C)N(C)C(=O)C1=NOC2(CCCN(Cc3ccccc3)C2)C1

$$$$
SWF004389
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 23 22  1  6  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  1  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004389

>  <SMILES>
CCc1ccccc1C(=O)N1CCC2(CC1)COC(CN(C)[C@H]1CC[C@H](O)CC1)C2

$$$$
SWF004390
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.8258   -0.3885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6033   -1.3634   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0483    0.5865   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8509   -0.1659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8007   -0.6110   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5561    0.7896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1707   -0.8990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5812    1.0121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1958   -0.6765   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  6  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 10  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004390

>  <SMILES>
COCCC1CN(Cc2ccc(S(C)(=O)=O)cc2)Cc2cccn2C1

$$$$
SWF004391
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.8986   -2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3986   -1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8053   -0.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004391

>  <SMILES>
COCCCN1CCO[C@H]2CN(C(=O)c3cnc(C)nc3)C[C@@H]21

$$$$
SWF004392
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0827   -5.1665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004392

>  <SMILES>
O=C(Nc1ccc(F)c(F)c1)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF004393
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004393

>  <SMILES>
O=C(c1cncnc1)N1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF004394
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004394

>  <SMILES>
CC(C)/C=C/C(=O)N1C[C@H]2CCN(Cc3cccnc3)CC[C@H]2C1

$$$$
SWF004395
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004395

>  <SMILES>
O=C(c1cc[nH]c1)N1CC[C@H]2OCC[C@@H](C(=O)N3CCCC3)[C@@H]2C1

$$$$
SWF004396
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004396

>  <SMILES>
CNC(=O)C[C@H]1C[C@H]2CN(C(=O)c3csc(C)n3)C[C@H]2O1

$$$$
SWF004397
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004397

>  <SMILES>
CC1(C(=O)N2CCn3c(-c4cccs4)cnc3C2)CC=CCC1

$$$$
SWF004398
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004398

>  <SMILES>
CC(C)/C=C/C(=O)N1C[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF004399
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 10 12  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004399

>  <SMILES>
CCOC1C2CCC1N(S(=O)(=O)c1ccc(OC)cc1)C2

$$$$
SWF004400
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.1431    0.9659   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3569    1.8320   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2636    3.6115   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1376    2.8025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4795    4.2807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3455    3.7807   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3750    5.2752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 15 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004400

>  <SMILES>
Cc1ccc(C(=O)N2CCCC3(CCN3C(=O)C(C)C)C2)o1

$$$$
SWF004401
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.9684    4.2346   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3386    3.6245   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1819    5.1163   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3583    2.8643   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0867    5.4482   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8910    2.5524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1083    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9299    6.9399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7164    6.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1046    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2854    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3460   -0.3882   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1900   -1.6631   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004401

>  <SMILES>
O=C(CC1(O)CCC1)N1CC2(CCN(S(=O)(=O)C3CC3)C2)C1

$$$$
SWF004402
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -1.6431    5.2961   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1431    4.4300   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6431    3.5640   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    4.4300   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1431    2.6980   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3569    3.5640   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1431    0.9659   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3569    1.8320   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    0.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8569    2.6980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5640   -0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004402

>  <SMILES>
CC(C)C(=O)N1CCC12CCCN(C(=O)c1ncc(Cl)cn1)C2

$$$$
SWF004403
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3917    0.5649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -0.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1348    1.2340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -1.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2283   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2283   -3.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -3.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -3.9297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  7  1  6  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  8  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004403

>  <SMILES>
O=C1C[C@H]2[C@@H](CCN2C(=O)C2(F)CCC2)N1Cc1ccncc1

$$$$
SWF004404
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.0036    6.1215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0485    4.6222   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8618    3.7046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2878    3.7772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4220    4.1252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8672    2.3374   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1178    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0664    5.5825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7850    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5698   -0.4028   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6266    6.0031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1506    6.6191   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1365   -0.8450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004404

>  <SMILES>
CCC(C)N1CCCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF004405
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.4859   -0.4902   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109    1.5137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3812    2.5840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    2.5840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -1.5137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3109    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
  6 10  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004405

>  <SMILES>
O=C(N1CCC1)C1(n2cccn2)CCN(Cc2cccnc2)CC1

$$$$
SWF004406
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0524    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  1  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004406

>  <SMILES>
O=C(c1ccccc1)N1CCO[C@@H]2CN(C(=O)C3CC3)C[C@@H]2C1

$$$$
SWF004407
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004407

>  <SMILES>
CN1CCO[C@@H]2CN(C(=O)Cc3ccc(F)cn3)CC[C@@H]2C1

$$$$
SWF004408
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004408

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CN(Cc2cccs2)CCO3)n1

$$$$
SWF004409
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004409

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2cccnc2)CC1

$$$$
SWF004410
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7788   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 17 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
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 18 19  2  0  0  0  0
 22 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004410

>  <SMILES>
O=C(c1cc2ccccc2[nH]1)N1Cc2ccnn2C(C(=O)N2CCOCC2)C1

$$$$
SWF004411
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004411

>  <SMILES>
O=C(c1cscn1)N1CCC(C(=O)Nc2ccccc2)(n2cccn2)CC1

$$$$
SWF004412
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.9718   -1.8190   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   15.3698    0.2313   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004412

>  <SMILES>
CN1CCN(c2ncc3c(n2)COC32CCN(S(=O)(=O)c3ccccc3)CC2)CC1

$$$$
SWF004413
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.9736   -6.1321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6618   -4.6649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7765   -3.6612   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -3.7397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5542   -2.8649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1013   -4.8824   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7823   -3.5459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004413

>  <SMILES>
O=C(C1CCC1)N1CC2(C1)OCCC2CCOc1cccnc1

$$$$
SWF004414
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3112   -1.5141   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5561  -10.5985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004414

>  <SMILES>
Cc1cccc(CN2CCCC(C(=O)N(C)C)(n3ccnc3)C2)c1

$$$$
SWF004415
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.2160    1.1086   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3887    2.0438   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3379    4.4623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7688    4.0751   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1365   -0.8450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7342    3.9143   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1143    5.9455   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 16 22  1  0  0  0  0
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 14 21  1  0  0  0  0
 15 17  1  0  0  0  0
 20 25  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF004415

>  <SMILES>
COCC1CCn2nccc2CN1C(=O)c1cccc2c1OCCO2

$$$$
SWF004416
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7790   -6.6250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004416

>  <SMILES>
Cc1nc(COC2CSC3(C2)CN(C(=O)C2CC2C)C3)cs1

$$$$
SWF004417
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0036   -0.0187   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004417

>  <SMILES>
Cc1ccccc1CN1CCCC(C(=O)N(C)C)(n2ccnc2)C1

$$$$
SWF004418
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.5586   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5586   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4938   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2469   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
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 14 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004418

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2cccnc2)C1

$$$$
SWF004419
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  6  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 14 10  1  1  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004419

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@@H]2CCN(C(=O)c3cc[nH]c3)C[C@@H]2O1

$$$$
SWF004420
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.5615    1.3993   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4951    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5996    2.0354   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9128    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004420

>  <SMILES>
O=C(N1C[C@H](OCCCn2cccn2)[C@H]2OCCC[C@H]21)C1(F)CC1

$$$$
SWF004421
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.5668   -5.9332   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4054   -5.3885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6623   -4.7194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7144   -6.3396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3836   -5.5964   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7112   -5.0284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8702   -3.7413   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0791   -3.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8417   -3.5042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0642   -2.1296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2620   -2.5968   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004421

>  <SMILES>
O=C1CCCN1Cc1nnc2n1CCN(C(=O)C1(F)CC1)CC2

$$$$
SWF004422
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5142    0.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4315    1.4854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0142    1.1489   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3450    1.8921   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5529    2.8702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004422

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)C4CC(O)C4)C3)CC2=O)cn1

$$$$
SWF004423
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    9.3585    5.9773   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.8585    5.1113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8585    5.1113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3585    4.2452   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3585    4.2452   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8585    3.3792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8585    3.3792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3585    2.5132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3585    2.5132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8585    3.3792   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8585    1.6472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4218    0.8209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8613    1.7219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1270   -0.1347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1811    0.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004423

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)Cc3ccc(F)cn3)CCC21

$$$$
SWF004424
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2007    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9016   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3084   -4.3385   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0929   -3.3205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7206   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6807   -4.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2739   -5.0430   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  8  7  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004424

>  <SMILES>
O=C(N1C[C@H](Oc2ccccn2)[C@H]2OCCC[C@H]21)C1(F)CC1

$$$$
SWF004425
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.5211    1.8037   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7346    2.6853   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3643    3.2954   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1158   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7423   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7259   -4.0808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3524   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8442   -5.2943   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2177   -4.2376   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8278   -5.6079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3196   -5.7647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9461   -6.8214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9297   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5562   -8.1917   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0480   -8.3485   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004425

>  <SMILES>
O=C(NC1CCS(=O)(=O)C1)C1=NOC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF004426
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.6867    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6941   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3850   -2.3227   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6722   -1.1637   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0542   -3.0658   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3413   -1.9069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0323   -2.8579   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004426

>  <SMILES>
c1cnc(N2CCO[C@H]3[C@H](OCCN4CCCC4)CC[C@@H]32)nc1

$$$$
SWF004427
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3112   -1.5141   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0036   -0.0187   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -4.5422   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3280    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0851   -1.0047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -6.0563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -6.8133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -8.3274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561   -6.0563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561   -9.0845   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8674   -6.8133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8674   -8.3274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561  -10.5985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004427

>  <SMILES>
Cc1cccc(CN2CCCC(C(=O)N(C)C)(n3cccn3)C2)c1

$$$$
SWF004428
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -3.9326   -9.0820   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -8.3252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3109   -9.0820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -6.8115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.3252   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3109   -6.0547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.8115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -6.0547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -6.8115   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -4.5410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9326   -1.5137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3154   -2.1293   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2402   -0.0161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6338    0.0157   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3283   -1.0045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5714    0.3064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9326    1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004428

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2ccc(F)cc2)C1

$$$$
SWF004429
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.5586   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5586   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -2.2720   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8703   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -3.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0286   -3.7783   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2540   -1.6559   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352   -4.5439   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5102   -4.0932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2675   -2.7815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5689   -0.1744   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -1.5146   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3281    0.3066   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0855   -1.0051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2469   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  1  0  0  0
  9 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 10 16  1  0  0  0  0
 11 12  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004429

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2occc2C)C1

$$$$
SWF004430
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -8.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 23 20  1  1  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7 10  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004430

>  <SMILES>
CN1CCN(Cc2ccncc2)C(=O)C12CCN(C(=O)C1CCOC1)CC2

$$$$
SWF004431
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.6184   -4.1523   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.6221   -5.2670   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0856   -3.8404   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3066   -2.6851   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5037   -5.1560   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1235   -1.4271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0486   -1.8681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0771   -4.6925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8156   -6.6232   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004431

>  <SMILES>
CC(C)S(=O)(=O)N1CC2(C1)OCCC2CCNC(=O)c1ccsc1

$$$$
SWF004432
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  6 10  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004432

>  <SMILES>
CC(C)N1CC[C@H]2OCC[C@@H](C(=O)NCc3cccnc3)[C@@H]2C1

$$$$
SWF004433
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1340    3.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    4.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004433

>  <SMILES>
COc1ccc(C(=O)N2C[C@@H]3OCCN(c4ccccn4)[C@H]3C2)cn1

$$$$
SWF004434
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0720   -2.1307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8703   -8.3305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004434

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(Cc2ccccc2C)C1

$$$$
SWF004435
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004435

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(C(=O)c2ccc(C)cn2)CC1

$$$$
SWF004436
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8198   -5.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4021   -6.5523   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2211   -4.8298   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3967   -6.4478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2156   -4.7253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8034   -5.5343   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004436

>  <SMILES>
O=C(Cc1ccc(O)cc1)N1CCC2(CC1)COC(CN1CCOCC1)C2

$$$$
SWF004437
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.5561   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -2.2711   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8674   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8674   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1786   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337   -4.5422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1786   -4.5422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4898   -2.2711   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3112   -1.5141   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4898   -3.7852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1786   -6.0563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0036   -0.0187   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3280    0.3065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0851   -1.0047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  2  0  0  0  0
 14 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004437

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2cccc(C)c2)C1

$$$$
SWF004438
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5374   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6587   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.3713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933   -5.1213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004438

>  <SMILES>
O=C(CC1CC1)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF004439
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    5.5549   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 21  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004439

>  <SMILES>
CC1CC1C(=O)N1CC2(C1)CN(CC1CC1)C(C(=O)N1CCCCO1)CO2

$$$$
SWF004440
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4413   -5.9885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  6  0  0  0
  8 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004440

>  <SMILES>
O=C(CC1(O)CCC1)N1CC[C@@]2(C[C@H](Nc3ccccn3)CCO2)C1

$$$$
SWF004441
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    8.4160   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004441

>  <SMILES>
CCCC(=O)N1C[C@H]2[C@@H](CCOCc3ccccn3)CO[C@H]2C1

$$$$
SWF004442
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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   -2.6225   -8.3274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  1  0  0  0
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 20 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004442

>  <SMILES>
CN(C)C(=O)C1(n2ccnc2)CCCN(Cc2ccc(F)cc2)C1

$$$$
SWF004443
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10  7  1  6  0  0  0
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M  END
>  <HTSID>
SWF004443

>  <SMILES>
CCc1ccc(C(=O)N2C[C@@H](C)[C@@]3(CCN(c4ccsc4)C3=O)C2)cn1

$$$$
SWF004444
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
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M  END
>  <HTSID>
SWF004444

>  <SMILES>
CCn1nccc1C(=O)N1C[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF004445
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    8.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 14 10  1  1  0  0  0
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M  END
>  <HTSID>
SWF004445

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1C[C@@H]2CCN(C(=O)c3cc[nH]n3)C[C@@H]2O1

$$$$
SWF004446
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004446

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(C)C)CC1

$$$$
SWF004447
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.8295    1.3993   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6766    1.4476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8676    2.0354   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  8  7  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004447

>  <SMILES>
Cc1cccc(CO[C@H]2CN(C(=O)C3(F)CC3)[C@@H]3CCCO[C@H]23)n1

$$$$
SWF004448
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511   -2.2908   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004448

>  <SMILES>
O=C(c1cc[nH]c1)N1C[C@H](OCc2cccnc2)[C@H]2OCCC[C@H]21

$$$$
SWF004449
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    9.0078   -3.1317   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5442   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5807   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0442   -4.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4259   -5.7718   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843    3.7172   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    3.8740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <HTSID>
SWF004449

>  <SMILES>
CCn1ncc2c1CN(Cc1ccc(C)s1)CC2COC

$$$$
SWF004450
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321    4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
 10  8  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004450

>  <SMILES>
O=C(NCc1cccs1)[C@@H]1CCO[C@@H]2CCN(c3ccncn3)C[C@H]21

$$$$
SWF004451
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    5.8444   -2.6828   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0625   -3.3063   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6262   -2.0593   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2209   -1.9010   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4678   -3.4646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2459   -2.1235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6547   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2209   -0.0990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  6  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 10 12  1  1  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004451

>  <SMILES>
CS(=O)(=O)N1CCO[C@@H]2CN(C(=O)C3CC3)CC[C@@H]2C1

$$$$
SWF004452
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2007    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  1  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004452

>  <SMILES>
O=C(N[C@H]1CN(C(=O)c2cc[nH]n2)[C@H]2CCCO[C@@H]12)c1cnccn1

$$$$
SWF004453
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.4480    0.1817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004453

>  <SMILES>
C=CCO[C@@H]1CCN(C(=O)c2cc[nH]c2)[C@H]1Cc1ccccc1

$$$$
SWF004454
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   11.1252   -7.5729   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.6579   -7.8848   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004454

>  <SMILES>
CC(C)N1CCC2(CC1)c1ncc(-c3cccc(F)c3)n1CCN2C

$$$$
SWF004455
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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 21 23  1  0  0  0  0
 13 16  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004455

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(CC2CCOCC2)CC1

$$$$
SWF004456
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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 13 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004456

>  <SMILES>
Cc1ccc(OCC(=O)N2CCCC(C(=O)N(C)C)(n3cccn3)C2)cc1

$$$$
SWF004457
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  7  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004457

>  <SMILES>
CCS(=O)(=O)N1CC2(CC(OCc3cnccc3C)CCO2)C1

$$$$
SWF004458
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    8.3690   -4.4525   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 24  1  0  0  0  0
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 14 15  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004458

>  <SMILES>
Cc1csc(C(=O)N2CCc3nc(C(=O)NCC4CC4)n(C)c3CC2)c1

$$$$
SWF004459
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.3660    0.8660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0365   -5.9918   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004459

>  <SMILES>
CN1CC2(COCCN(c3cc(C(F)(F)F)ncn3)C2)CC1=O

$$$$
SWF004460
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990    6.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF004460

>  <SMILES>
Cn1cncc1CN1CCCC2(CCC(=O)N2Cc2ccc(F)cc2)CC1

$$$$
SWF004461
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8380   -2.2788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004461

>  <SMILES>
O=C(c1ccccc1)N1CCOC2(C1)C(=O)NCC2c1ccccc1

$$$$
SWF004462
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    7.5191   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1883   -2.7601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004462

>  <SMILES>
COCCNC(=O)C1CCc2c(C(=O)NCC(C)C)ncn2C1

$$$$
SWF004463
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004463

>  <SMILES>
O=C(c1cncnc1)N1CC2(CC(N3CCOCC3)CS2)C1

$$$$
SWF004464
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004464

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2CC1CCCCC1

$$$$
SWF004465
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4974    1.9572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7921    1.0016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1119    0.2686   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7670    0.7791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1564    0.5633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4773   -0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9773   -1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1458    0.4644   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9884   -1.6774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1207    0.2419   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004465

>  <SMILES>
CCCN1CCOC2(COCCN(C(=O)C3CC(O)C3)C2)C1

$$$$
SWF004466
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
   -0.0000    8.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2054    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004466

>  <SMILES>
CC(C)Oc1ccccc1CN1C[C@@H](C(=O)N(C)C)C[C@H]2OCC[C@H]21

$$$$
SWF004467
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6337   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9427   -4.3761   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3247   -4.3761   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004467

>  <SMILES>
Cn1cnc(C(=O)N2C[C@H](Oc3ccccn3)[C@H]3OCCC[C@H]32)n1

$$$$
SWF004468
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.8074    2.1755   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3646    3.0059   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0225    2.2528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1713    3.9870   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4182    3.3291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0036    2.4461   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6993    1.3065   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7064    1.1871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4117    0.6047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3071   -0.3898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004468

>  <SMILES>
CN(C)CC1COC2(COCCN(C(=O)C3(F)CC3)C2)C1

$$$$
SWF004469
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.8891    0.7524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2229    2.2148   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7896    1.7727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8689   -0.3472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.3515    0.4186   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4169   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4355    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7937   -1.0147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3718    1.5182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6669   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3379   -4.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004469

>  <SMILES>
CN(C)S(=O)(=O)N1Cc2ccnn2CC(COCC2CC2)C1

$$$$
SWF004470
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 21 19  1  6  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  1  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004470

>  <SMILES>
CC(C)n1nc(CN2CCCC2=O)c2c1CN(C(=O)[C@H]1CC[C@H](C)CC1)C2

$$$$
SWF004471
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.5914   -6.0611   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.1847   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3712   -3.3205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 11 10  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
  6  8  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004471

>  <SMILES>
C=CCO[C@@H]1CN(C(=O)c2cccc(Cl)c2)[C@@H]2COC[C@@H]21

$$$$
SWF004472
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    9.2498    5.1731   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7498    5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2498    7.7711   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004472

>  <SMILES>
Cc1ncccc1NC(=O)[C@H]1C[C@@H]2CCN(CCc3ccccc3)C[C@H]2O1

$$$$
SWF004473
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 20 22  1  6  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004473

>  <SMILES>
O=C(NCC1CC1)[C@@H]1CN(C(=O)C2[C@H]3COC[C@@H]23)C[C@H]2OCC[C@H]21

$$$$
SWF004474
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.3462    0.3183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004474

>  <SMILES>
CC(C)NC(=O)CN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccco1)C2

$$$$
SWF004475
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004475

>  <SMILES>
COCC1CC2(CCN(C(=O)Cc3cccc(F)c3F)CC2)CN1C

$$$$
SWF004476
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
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 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004476

>  <SMILES>
CNC(=O)C[C@H]1C[C@H]2CN(C(=O)c3ncc(Cl)cn3)C[C@H]2O1

$$$$
SWF004477
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004477

>  <SMILES>
Cc1nc(C(=O)N2CCCC3(COCCN(c4nccs4)C3)C2)cs1

$$$$
SWF004478
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004478

>  <SMILES>
O=C(C1CC(O)C1)N1CC[C@H]2CC(C(=O)N3CCCC3)O[C@H]2C1

$$$$
SWF004479
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3587   -2.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0762    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9165   -1.6570   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  9  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004479

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)Cc3ccccc3)CC2)C1=O

$$$$
SWF004480
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9209   -3.7459   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004480

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(OCc3cccnc3)CCO2)C1

$$$$
SWF004481
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4847   -1.5973   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  2  0  0  0  0
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  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  6  0  0  0
 16 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 15 19  1  0  0  0  0
 17 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004481

>  <SMILES>
CN(C)C[C@@H]1CO[C@@H]2CN(C(=O)c3cn(C)c4ccccc34)C[C@H]12

$$$$
SWF004482
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 14  1  6  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004482

>  <SMILES>
CC1CC(C(=O)N2C[C@H](C(=O)N3CCCC3)[C@@H]3CCO[C@@H]3C2)C1

$$$$
SWF004483
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004483

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CC[C@H](O)[C@@H]1Cc1cccnc1

$$$$
SWF004484
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
    8.2422    0.6497   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6071   -0.1227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3402    1.0010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4149    1.3802   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 28 30  1  0  0  0  0
 29 31  2  0  0  0  0
 30 32  2  0  0  0  0
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 15 17  1  0  0  0  0
 16 20  1  0  0  0  0
 21 22  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF004484

>  <SMILES>
O=C(NCC1CCC2CN(C(=O)c3ccccc3)c3ccccc3CN12)c1ccccc1

$$$$
SWF004485
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004485

>  <SMILES>
CCN1CCC2(CCN(C(=O)c3cccc(F)c3)CC2)CC1=O

$$$$
SWF004486
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    1.7801   -2.0287   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 17 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004486

>  <SMILES>
COCCNC(=O)c1cnn2c1CN(C(=O)C1CC(F)(F)C1)CCC2

$$$$
SWF004487
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  2  4  2  0  0  0  0
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 13 14  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004487

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)c4cccs4)C[C@H]32)cs1

$$$$
SWF004488
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  8 10  1  0  0  0  0
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 14 15  1  0  0  0  0
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 19 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF004488

>  <SMILES>
CNC(=O)C[C@@H]1OC[C@H]2CN(c3nc(C)cc(C)n3)CC[C@H]21

$$$$
SWF004489
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    6.4952   -4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 11  1  1  0  0  0
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 27 28  1  0  0  0  0
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 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF004489

>  <SMILES>
Cc1cc(CN2C[C@@H](C(=O)NCc3cc(F)cc(F)c3)C[C@H]3OCC[C@H]32)[nH]n1

$$$$
SWF004490
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    8.5584   -1.9297   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2905   -0.9297   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
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 12 16  1  0  0  0  0
 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004490

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2CC(O)CO)N1Cc1cccc(F)c1F

$$$$
SWF004491
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004491

>  <SMILES>
Cc1noc(C)c1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF004492
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 17 21  1  0  0  0  0
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 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF004492

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(C(=O)c2ccncc2)CC1

$$$$
SWF004493
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 25 26  1  0  0  0  0
 11 14  1  0  0  0  0
 16 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004493

>  <SMILES>
CNC(=O)C1(Nc2cccc(OC)c2)CCN(Cc2cnn(C)c2)CC1

$$$$
SWF004494
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.5412   -6.4819   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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M  END
>  <HTSID>
SWF004494

>  <SMILES>
O=C(NC1CCC1)C1=NO[C@@H]2CN(C(=O)c3ccsc3)C[C@H]12

$$$$
SWF004495
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    8.2422    0.6497   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  2  0  0  0  0
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 14 20  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
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 27 28  2  0  0  0  0
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 28 30  1  0  0  0  0
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 21 22  1  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <HTSID>
SWF004495

>  <SMILES>
Cc1noc(C)c1C(=O)NCC1CCC2CN(C(=O)c3ccccc3)c3ccccc3CN12

$$$$
SWF004496
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004496

>  <SMILES>
O=C(N1CCCC2(CCN(c3ccccc3)C2=O)C1)C1(F)CC1

$$$$
SWF004497
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.0036    6.1215   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004497

>  <SMILES>
CC(C)CN1CCCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF004498
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 11  1  0  0  0  0
 12 13  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004498

>  <SMILES>
O=C(C1CC(O)C1)N1CCc2ncnc(-c3cccnc3)c2CC1

$$$$
SWF004499
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8370   -4.2687   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0450   -3.2905   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5802   -4.9378   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  8  9  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004499

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC2(Cc3ncc(-c4cccnc4)n3C2)C1

$$$$
SWF004500
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 12 10  1  6  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 11  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004500

>  <SMILES>
O=C(NCC1OCCc2cn(Cc3ccccc3)nc21)C1(F)CCOCC1

$$$$
SWF004501
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004501

>  <SMILES>
COc1ccc(CN2CCCC3(CCC(=O)N3Cc3ccccc3)CC2)cc1

$$$$
SWF004502
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004502

>  <SMILES>
Cn1cc(N2CC3(CCN(C(=O)C4(F)CC4)C3)CC2=O)cn1

$$$$
SWF004503
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 24 26  2  0  0  0  0
 15 10  1  6  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004503

>  <SMILES>
Cn1nccc1C(=O)N1CC[C@@H]2C[C@@H](C(=O)Nc3cnccn3)O[C@H]2C1

$$$$
SWF004504
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004504

>  <SMILES>
CS(=O)(=O)N1CCCCC1C1CCN(C(=O)c2cccs2)CC1

$$$$
SWF004505
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.5820   -0.6817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004505

>  <SMILES>
Cc1ccc(CC(=O)N2C[C@H](C(=O)N(C)C)C3OCCC32)cc1

$$$$
SWF004506
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9535   -3.6160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004506

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCC3(CC2)CC(=O)N(C)C3)c1

$$$$
SWF004507
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    6.8690    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8690    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 25 29  2  0  0  0  0
 26 30  2  0  0  0  0
 28 31  2  0  0  0  0
  5  6  2  0  0  0  0
 12 13  1  0  0  0  0
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 27 30  1  0  0  0  0
 29 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004507

>  <SMILES>
O=C(Nc1ccccc1)c1ccc2c(c1)C(C1CCN(c3ncccn3)CC1)C(=O)N2

$$$$
SWF004508
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.3236   -3.4293   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 22 24  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 17 19  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004508

>  <SMILES>
O=C(NC1CC1)c1cnn2c1CN(C(=O)c1ccccc1)CCC2

$$$$
SWF004509
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
   11.2583    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
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 27 28  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004509

>  <SMILES>
COCCNC(=O)CC1CCC2(CC1)CCN(C(=O)Cc1ccccc1)CC2

$$$$
SWF004510
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.9090   -2.1321   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  1  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004510

>  <SMILES>
Cc1nnc(N2C[C@@H]3C[C@@H](CC(=O)NC4CCC4)O[C@@H]3C2)s1

$$$$
SWF004511
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
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 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 12 13  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004511

>  <SMILES>
O=C1CC2(CCN(S(=O)(=O)c3cccs3)C2)CN1c1ccccc1

$$$$
SWF004512
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 26 27  1  0  0  0  0
 11 14  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004512

>  <SMILES>
CN1CCN(c2ncc3c(n2)C2CCC3N(C(=O)c3ncn(C)n3)C2)CC1

$$$$
SWF004513
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.4098   -2.1658   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0031   -1.2522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8339    0.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 12  1  0  0  0  0
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 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004513

>  <SMILES>
CCN1C(=O)[C@]2(CC[C@@H]3CN(CC(=O)N(C)C)C[C@@H]32)N=C1C

$$$$
SWF004514
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    3.8091   -5.8978   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4972   -7.3650   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004514

>  <SMILES>
CC(C)OCc1nn(C)c2c1CN(S(=O)(=O)N(C)C)CC2

$$$$
SWF004515
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7988   -1.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4679   -0.8226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1589    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 16 22  1  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 17 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004515

>  <SMILES>
Cc1noc(C)c1CN1C[C@H](OCC2CC2)[C@H]2OCCC[C@H]21

$$$$
SWF004516
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4494    0.5472   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.4371    0.3907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3326    1.3852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6181   -1.3318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  7  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004516

>  <SMILES>
CC(C)NC(=O)C1CCC2(CCN(C(=O)C3(F)CC3)CC2)C1

$$$$
SWF004517
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.0963    1.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622    2.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622    2.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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 10 12  1  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004517

>  <SMILES>
O=C1CCC2(CCN(C(=O)C3(F)CC3)CC2)CN1CC1CC1

$$$$
SWF004518
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    8.5384   -2.1181   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3202   -1.4946   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7038   -1.5672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9699   -0.6033   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3464    0.1786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7117    1.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3575    0.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7341    0.8114   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9922   -0.9014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2452    1.5283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5233    0.9972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004518

>  <SMILES>
C=CCN1CCOC2CN(C(=O)c3csnn3)CCC2C1

$$$$
SWF004519
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1044   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -3.1397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -4.7577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  1  0  0  0
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 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004519

>  <SMILES>
CC(=O)c1cc(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)n[nH]1

$$$$
SWF004520
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    8.3591   -1.9332   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9524   -2.8467   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5402   -3.6557   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5511   -3.8648   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3701   -2.1422   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1334   -4.5693   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1389   -4.6738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3756   -2.2468   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7064   -1.5036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  1  0  0  0
 13 11  1  1  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004520

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(Cc4ccccc4F)C[C@@H]32)C(=O)N1CC1CC1

$$$$
SWF004521
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004521

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(C(=O)c3cc(C4CC4)on3)CC2)C1

$$$$
SWF004522
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004522

>  <SMILES>
Cc1cccc(N2CCc3ncnc(N4CCOCC4)c3CC2)n1

$$$$
SWF004523
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004523

>  <SMILES>
c1cncc(OC2CC3COCC(C2)N3Cc2nccs2)c1

$$$$
SWF004524
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004524

>  <SMILES>
Cc1nc(N2CCCC2)nc2c1CCN(C(=O)N1CCCC1)CC2

$$$$
SWF004525
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  7  9  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004525

>  <SMILES>
Cn1c(C(=O)N2CC[C@H](O)[C@@H]2Cc2ccccc2)cccc1=O

$$$$
SWF004526
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1092   -4.6684   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6840   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 14  1  6  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004526

>  <SMILES>
O=C(NC1CCC1)C1=NO[C@@H]2CN(C(=O)Cc3cccc(F)c3F)C[C@H]12

$$$$
SWF004527
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    5.7990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8371   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004527

>  <SMILES>
O=C(CC1(O)CCC1)N1CC[C@@H]2OCCN(S(=O)(=O)C3CC3)[C@H]2C1

$$$$
SWF004528
Actelion Java MolfileCreator 1.0

 30 35  0  0  1  0  0  0  0  0999 V2000
    1.2990    5.1213   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.6213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3597    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2384    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5932   -3.5408   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2033   -4.9111   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9502   -2.7977   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2090    2.0034   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3237    0.9997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  6  7  2  0  0  0  0
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  8  9  2  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 12 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
  4  5  1  0  0  0  0
 13 11  1  6  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 28  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF004528

>  <SMILES>
O=C(C1=NO[C@H]2CCC3(CCN(Cc4ccc5cn[nH]c5c4)CC3)[C@@H]12)N1CC(F)C1

$$$$
SWF004529
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491   -1.6910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5491   -3.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7071   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7071   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -5.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -6.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  6  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 13  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004529

>  <SMILES>
CC1CC(C(=O)N2C[C@H]3OCC[C@H]3[C@H](C(=O)NC3CCC3)C2)C1

$$$$
SWF004530
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.3818    3.7433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7831    4.7614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7776    4.8659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1953    5.5704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1843    5.7795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6020    6.4840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5965    6.5885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  1  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  1  0  0  0
 16 19  1  0  0  0  0
 16 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004530

>  <SMILES>
CN(C)C[C@H]1CCC[C@]2(CCN(C(=O)[C@H]3CC[C@H](C)CC3)C2)O1

$$$$
SWF004531
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6505    2.1508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9843    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3862    3.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    4.7860   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2041    6.0253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0099    8.6161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 15 18  1  1  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004531

>  <SMILES>
CN1CCOC2(CCCN(C(=O)[C@H]3CC[C@H](C)CC3)CC2)C1

$$$$
SWF004532
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    4.1375   -5.3885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3943   -4.7194   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6022   -3.7413   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4433   -5.0284   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8112   -3.1295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5737   -3.5042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4651   -4.8205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7741   -5.7716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7962   -2.1296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9941   -2.5968   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1561   -5.7716   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004532

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCc2nnc(COCC3CC3)n2CC1

$$$$
SWF004533
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.1996    2.0086   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0713    3.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3642    2.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1054    3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004533

>  <SMILES>
COCCN1CCO[C@H]2CCN(C(=O)C3(F)CCC3)C[C@@H]21

$$$$
SWF004534
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.1499    1.1118   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    2.7990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.4474   -2.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004534

>  <SMILES>
O=C(N1CCC2(CC1)CCN(c1cncnc1)C2=O)C1(F)CC1

$$$$
SWF004535
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1654   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0314   -4.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004535

>  <SMILES>
c1cnc(NC2COC3(CCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF004536
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.6913   -7.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004536

>  <SMILES>
COCc1cncc2c1CCN(C(=O)c1cccc(Cl)n1)C2

$$$$
SWF004537
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    7.3712   -6.4014   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8712   -7.2674   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8712   -7.2674   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1802   -5.8137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622   -5.8137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1313   -6.1227   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5622   -5.8137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -4.2748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
  6  8  1  0  0  0  0
 12 10  1  1  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004537

>  <SMILES>
C=CCOc1ccc(C(=O)N2C[C@H]3C[C@H]4[C@](C2)(CN(C)S4(=O)=O)O3)cc1

$$$$
SWF004538
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004538

>  <SMILES>
O=C(c1cscn1)N1CCC2(CN(Cc3ccsc3)C2)C1

$$$$
SWF004539
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004539

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(CC1)COCCN(C)C2

$$$$
SWF004540
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.6589   -4.1003   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4590   -3.5005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4146   -3.7952   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6573   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004540

>  <SMILES>
Cc1ccc(C)c(CN2CCOCC3(CC(=O)N(C)C3)C2)c1

$$$$
SWF004541
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004541

>  <SMILES>
O=C(C1CCOC1)N1CCC2(CC1)CN(Cc1cccs1)CCO2

$$$$
SWF004542
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  6  0  0  0
  9 10  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004542

>  <SMILES>
C[C@H]1C[C@H]2CN(C(=O)c3ccnc(C(F)(F)F)c3)CC[C@@H]2O1

$$$$
SWF004543
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 13  1  0  0  0  0
 16 17  2  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004543

>  <SMILES>
COCc1nnc2n1CCN(C(=O)COc1ccccc1)C2C

$$$$
SWF004544
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.9282    4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004544

>  <SMILES>
CCC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NC2CC2)CC1

$$$$
SWF004545
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.5340   -1.4390   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 18 21  2  0  0  0  0
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 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004545

>  <SMILES>
Cc1ccccc1C(=O)N1CC2(CCN(S(C)(=O)=O)C2)C1

$$$$
SWF004546
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004546

>  <SMILES>
CC(C)N(C)C(=O)C1=NOC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF004547
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004547

>  <SMILES>
CC(C)CC(=O)N1CCC2(C1)c1cccn1-c1ncccc1N2CC(C)C

$$$$
SWF004548
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 24 26  1  0  0  0  0
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 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF004548

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H](C)[C@@]3(CCN(Cc4cccnc4)C3=O)C2)o1

$$$$
SWF004549
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004549

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cccc(C)n3)CC2)CO1

$$$$
SWF004550
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 12 16  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004550

>  <SMILES>
O=C(c1ncccn1)N1C[C@H]2CCC[C@@]2(COCC2CC2)C1

$$$$
SWF004551
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.8734    1.7633   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004551

>  <SMILES>
O=C(N1CCOC2CCC1C2OCc1cccnc1)C1(F)CC1

$$$$
SWF004552
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.0349   -4.4431   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004552

>  <SMILES>
O=C(N1C[C@H](Oc2ncccc2F)[C@H]2OCCC[C@H]21)C1(F)CCC1

$$$$
SWF004553
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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   -2.5567    0.5720   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.4503   -0.7269   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
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 10 12  1  0  0  0  0
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 20 21  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004553

>  <SMILES>
CCN1CCC2(CCCN(C(=O)c3cccs3)CC2)C1=O

$$$$
SWF004554
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
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 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004554

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(C(=O)C3CCOC3)C2)C1

$$$$
SWF004555
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
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 15 20  1  0  0  0  0
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  9 13  1  0  0  0  0
 14 18  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004555

>  <SMILES>
O=C(C1CCC1)N1CCC2(C1)c1cccn1-c1ncccc1N2CCF

$$$$
SWF004556
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  6  8  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 20  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004556

>  <SMILES>
CC(=O)N1CC(=O)N(c2ccsc2)CC12CCN(C(=O)C1CCOC1)C2

$$$$
SWF004557
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7  5  1  6  0  0  0
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  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004557

>  <SMILES>
Cc1occc1C(=O)N1CC(F)(F)CC2(CCN(C)C2=O)C1

$$$$
SWF004558
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   11.2776   -8.0216   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2739   -6.9069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4912   -5.9197   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004558

>  <SMILES>
Cc1nc(C(=O)N2CCCC3(CC(C(=O)NCc4cccnc4)=NO3)C2)cs1

$$$$
SWF004559
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 14 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004559

>  <SMILES>
CO[C@H]1CCN(C(=O)c2ccoc2)[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF004560
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    5.0025   -3.4373   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004560

>  <SMILES>
O=C(N1CC2(C1)OCCC2CCOCc1ccccn1)C1(F)CC1

$$$$
SWF004561
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
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 17 20  2  0  0  0  0
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 20 22  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004561

>  <SMILES>
Cc1ccc(CN2C(=O)CCC23CCCN(CCc2ccccc2)CC3)cc1

$$$$
SWF004562
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004562

>  <SMILES>
Cc1ccc(CN2C(=O)CCC23CCCN(CC2CC2)CC3)cc1

$$$$
SWF004563
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
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 14 15  1  0  0  0  0
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 27 28  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <HTSID>
SWF004563

>  <SMILES>
O=C(c1cc2ccccc2cc1O)N1CCCC2(CCCN2Cc2cccc(F)c2)CC1

$$$$
SWF004564
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004564

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)CC(=O)N(CC1CC1)C2

$$$$
SWF004565
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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  6 10  1  6  0  0  0
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 11 14  1  0  0  0  0
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 27 28  1  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004565

>  <SMILES>
CCC(C)CN1C[C@H]2C(=O)NC3(CCN(C(=O)c4ccc(C)cc4)CC3)[C@H]2C1

$$$$
SWF004566
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 23 24  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  4  6  1  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004566

>  <SMILES>
O=C1CCC2(CCCN(c3ncc4sccc4n3)CC2)N1CC1CCCCC1

$$$$
SWF004567
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004567

>  <SMILES>
COCC1CC2(CCN(C(=O)c3conc3C)CC2)CN1C

$$$$
SWF004568
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.8565    0.7672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004568

>  <SMILES>
CCN1CCC2(CCCN(C(=O)Cc3ccccn3)CC2)C1=O

$$$$
SWF004569
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  6  0  0  0
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 17 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004569

>  <SMILES>
Cn1ccc(CC(=O)N2CC[C@H]3O[C@@H](C(=O)NCc4cccnc4)CC[C@H]32)n1

$$$$
SWF004570
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.1941   -3.4553   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5250   -2.7121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6115   -3.1189   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004570

>  <SMILES>
O=C(NC1CC1)C1=NO[C@@H]2CN(C(=O)c3cccs3)C[C@H]12

$$$$
SWF004571
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6  7  1  0  0  0  0
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  9  7  1  1  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
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 23 26  2  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004571

>  <SMILES>
CS(=O)(=O)CCN1C(=O)CCC12CCCN(Cc1cccc(F)c1)CC2

$$$$
SWF004572
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004572

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCC3(CCCNC3=O)CC2)c1

$$$$
SWF004573
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004573

>  <SMILES>
c1ccc(CN2CC3(CC(OCC4CCOCC4)CS3)C2)cc1

$$$$
SWF004574
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004574

>  <SMILES>
Cc1cc(OC[C@H]2CO[C@@H]3CN(C(=O)Cc4ccccc4)C[C@H]23)cc(C)n1

$$$$
SWF004575
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004575

>  <SMILES>
O=C(NCc1cccs1)C1CN(C(=O)Cc2ccccc2)C2CCOC12

$$$$
SWF004576
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004576

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF004577
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004577

>  <SMILES>
O=C(NCC1CCCCC1)c1nnc2n1CCN1CCN(C(=O)Cc3ccccc3)CC21

$$$$
SWF004578
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004578

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CC1)CC(N1CCOCC1)CO2

$$$$
SWF004579
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004579

>  <SMILES>
O=C(N1CC[C@]2(CCC[C@H](CN3CCCC3)O2)C1)C1(F)CCC1

$$$$
SWF004580
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004580

>  <SMILES>
COc1ncnc2c1CCN(C(=O)c1csc(C)n1)CC2

$$$$
SWF004581
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004581

>  <SMILES>
CN1CCOC2CN(C(=O)Cn3cc(Cl)cn3)CCC2C1

$$$$
SWF004582
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004582

>  <SMILES>
O=C(c1cc[nH]c1)N1CCc2ncc(CN3CCOCC3)n2CC1

$$$$
SWF004583
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004583

>  <SMILES>
Cc1cccc(F)c1C(=O)N1C[C@@H]2C[C@@H](CC(=O)N3CCC3)O[C@@H]2C1

$$$$
SWF004584
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004584

>  <SMILES>
COc1cnccc1C(=O)N1CC2(CCN2C(=O)c2cnn(C)c2)C1

$$$$
SWF004585
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004585

>  <SMILES>
CNC(=O)CC1CN(Cc2cccc3[nH]ccc23)Cc2cccn2C1

$$$$
SWF004586
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF004586

>  <SMILES>
CN(C)Cc1nnn2c1CN(C(=O)Cc1ccc(F)cn1)CCC2

$$$$
SWF004587
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004587

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(C(C)=O)C3)C2)cc1

$$$$
SWF004588
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004588

>  <SMILES>
O=C(N1CCC1)C1(n2ccnc2)CCN(S(=O)(=O)c2ccccc2)CC1

$$$$
SWF004589
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF004589

>  <SMILES>
O=C(c1cc[nH]n1)N1CC[C@]2(C1)C(=O)NC[C@@H]2COc1ccccn1

$$$$
SWF004590
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 21 23  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004590

>  <SMILES>
CN(C)CCN1CCC2(CCCN(C(=O)c3cc[nH]n3)C2)C1=O

$$$$
SWF004591
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
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 11 14  1  0  0  0  0
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 23 26  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <HTSID>
SWF004591

>  <SMILES>
CN1CC2(CCN(C(=O)c3ccco3)CC2)c2nc(-c3ccccc3)ncc2C1=O

$$$$
SWF004592
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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M  END
>  <HTSID>
SWF004592

>  <SMILES>
O=C(c1cc[nH]c1)N1CC2(CCN(S(=O)(=O)C3CC3)C2)C1

$$$$
SWF004593
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF004593

>  <SMILES>
Cc1cc(C)nc(N2CCC3(CC2)Cc2ccccc2CN(Cc2cccnc2)C3=O)n1

$$$$
SWF004594
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004594

>  <SMILES>
COCC(C)NC(=O)c1nc2c(o1)CCN(Cc1ccccc1)C2

$$$$
SWF004595
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
   12.1172    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.8672    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6500    0.8165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8635    2.9184   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.3590    1.9604   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932    2.3083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942    3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8951    2.3083   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5248    2.9184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004595

>  <SMILES>
Cc1nc(C(=O)N2C[C@H]3CN(CC(C)C)C(=O)[C@H]3C2)cs1

$$$$
SWF004596
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -2.4959    2.2603   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0287    2.5721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5126    2.0320   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5541    6.1412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6273    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 21  2  0  0  0  0
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 13 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004596

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)c1cc(C)cs1)C2

$$$$
SWF004597
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.0468   -2.5685   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 11 13  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004597

>  <SMILES>
CSCC(=O)N1CCn2cc(C(=O)NCc3ccccn3)nc2C1C

$$$$
SWF004598
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.1198    8.2937   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004598

>  <SMILES>
COCc1ccccc1-c1cnc2n1CCN(C(=O)c1cccc(F)c1C)CC2

$$$$
SWF004599
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.1576   -2.4387   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004599

>  <SMILES>
O=C(c1cscn1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF004600
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 17 15  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  9 10  2  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF004600

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CCC1(CC2)CCN(C(=O)Cc2ccccn2)C1

$$$$
SWF004601
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3846   -3.1317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8116   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 11 10  1  1  0  0  0
 13 16  1  0  0  0  0
 18 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004601

>  <SMILES>
COc1ccc(NC(=O)C2=NOC3(CCCN(C(=O)C4CC4)C3)C2)cc1

$$$$
SWF004602
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.5561   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5561   -1.5141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2449   -2.2711   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2449   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 14 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 18 23  2  0  0  0  0
 20 24  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004602

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2ccc(C)cc2)C1

$$$$
SWF004603
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004603

>  <SMILES>
Cc1ccccc1CN1CCC(C(=O)N(C)C)(n2ccnc2)CC1

$$$$
SWF004604
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
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 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 23 26  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF004604

>  <SMILES>
O=C(c1ccsc1)N1CCOC2(C1)C(=O)N(Cc1cccs1)CC2c1ccccc1

$$$$
SWF004605
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004605

>  <SMILES>
O=C(c1ccsc1)N1C[C@H]2[C@@H](C1)OC[C@H]2C(=O)N1CCOCC1

$$$$
SWF004606
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  7  1  0  0  0  0
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 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004606

>  <SMILES>
C1CCC(N2CC3(CC(OCC4CCOCC4)CS3)C2)C1

$$$$
SWF004607
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 20 23  1  0  0  0  0
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 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004607

>  <SMILES>
CC(C)N1CC2(COCCN(Cc3cccc(F)c3)C2)CC1=O

$$$$
SWF004608
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004608

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(CC(=O)N(c3cncnc3)C2)C1

$$$$
SWF004609
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004609

>  <SMILES>
Cc1nc(C(=O)N2CC3(CCN(C(=O)c4ccoc4)C3)C2)cs1

$$$$
SWF004610
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.9073    1.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004610

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CC2)CC(=O)N(C)C3)cc1

$$$$
SWF004611
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004611

>  <SMILES>
CC(C)N(C)CC(=O)N1CCc2ncc(CN(C)C)n2CC1

$$$$
SWF004612
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
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 10  8  1  6  0  0  0
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M  END
>  <HTSID>
SWF004612

>  <SMILES>
O=C(N1C[C@H]2[C@@H](C1)c1ccccc1[C@@H]2N1CCOCC1)C1(F)CC1

$$$$
SWF004613
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    6.2146    0.0783   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004613

>  <SMILES>
CC(C)N1Cc2ccccc2CC2(CCN(C(=O)C3(C(N)=O)CC3)CC2)C1=O

$$$$
SWF004614
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 17 20  1  0  0  0  0
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 14 19  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF004614

>  <SMILES>
O=S(=O)(c1ccc(F)cc1)N1Cc2ccnn2CCC1CO

$$$$
SWF004615
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6508    4.9230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1217    5.7258   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3838    6.2353   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5926    6.5287   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1291    7.9553   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1328    9.0700   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 26 27  1  0  0  0  0
  9 11  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004615

>  <SMILES>
CCC(C)C(=O)N1CC2(CCOCC2)c2cc(-c3ccc(C)cc3)ccc21

$$$$
SWF004616
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    1.8570   -4.5750   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9168   -3.5768   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7962   -2.1296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6022   -3.7413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3075   -1.4768   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6467   -2.9224   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5869   -1.9241   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4215   -1.3733   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3159   -1.8206   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 12 16  1  0  0  0  0
 13 15  1  0  0  0  0
 17 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004616

>  <SMILES>
CCc1ccc(C(=O)N2CCCn3ncc(C(=O)N(C)CC)c3C2)cn1

$$$$
SWF004617
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004617

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccnc(F)c2)C[C@H]1Cc1ccccc1

$$$$
SWF004618
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
   -0.5788    0.4775   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0313    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8504    3.0613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5268    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2731    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6157    4.5429   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3319    3.2960   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7403    2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0972    4.7775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
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 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 20 25  2  0  0  0  0
 23 26  2  0  0  0  0
  8 11  1  0  0  0  0
  9 10  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  2  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004618

>  <SMILES>
C=CCN1c2cccnc2-n2cccc2C12CCN(C(=O)C1CCC1)C2

$$$$
SWF004619
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.4646    6.0646   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004619

>  <SMILES>
COCC1CC2(CCN(C(=O)C3(F)CCC3)CC2)CN1C(=O)c1cscn1

$$$$
SWF004620
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7159   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080   -2.5577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2191    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0602    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2293    3.0782   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2511    2.8702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004620

>  <SMILES>
COCCN1CC[C@]2(CN(C(=O)c3cc[nH]c3)C[C@H]2C)C1=O

$$$$
SWF004621
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -1.0131    4.3402   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2210    3.3620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1721    3.0530   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3800    2.0749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6858    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6369    1.4057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0573    1.0456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1506    0.0675   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004621

>  <SMILES>
COC[C@H]1CCC[C@@]12CN(C(=O)c1ccnc(F)c1)CCO2

$$$$
SWF004622
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -0.8180   -2.0287   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1471   -3.3703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6444   -3.2806   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.1538   -4.8398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3225   -3.0694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6233   -4.5389   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8752   -5.3653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7855   -6.8626   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2168   -4.6943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1943   -3.1945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4034   -5.6119   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8606   -5.2563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4911   -3.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004622

>  <SMILES>
CCN(C)C(=O)c1cnn2c1CN(C(=O)C1CC(F)(F)C1)CCC2

$$$$
SWF004623
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1813    0.5419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  3  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004623

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC(=O)N(c4cccc(C#N)c4)C3)C2)C1

$$$$
SWF004624
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6520    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8412   -1.5665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.2971   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.9112   -4.7342   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 15 13  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004624

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]2O1)NCc1cccs1

$$$$
SWF004625
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3147   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3092   -0.2681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7160   -1.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7105   -1.2862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1282   -1.9907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1172   -2.1997   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5349   -2.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5295   -3.0088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004625

>  <SMILES>
O=C(C1CC(F)C1)N1CCCC2(CC(Oc3cccnc3)CO2)C1

$$$$
SWF004626
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7159   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5468    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5080   -2.5577   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5249   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2191    0.1818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0602    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8033    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1091    1.7780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5954    3.1163   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9012    2.7561   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6443    3.4253   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4364    4.4034   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 18 15  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  1  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004626

>  <SMILES>
COCCN1CC[C@]2(CN(C(=O)[C@H]3CC[C@H](C)CC3)C[C@H]2C)C1=O

$$$$
SWF004627
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2298   -2.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5526   -3.9169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 17 19  1  6  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004627

>  <SMILES>
COc1ccc(CC(=O)N2C[C@@H]3CN(C)CCO[C@@H]3C2)cc1F

$$$$
SWF004628
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004628

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)Cc2ccccc2)CC1

$$$$
SWF004629
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0327   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8417   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0109   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3636   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5109   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3199   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6508   -3.3966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0630    1.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0141    0.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8551    2.2121   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  1  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  1  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 10 12  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004629

>  <SMILES>
COCCOCC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(C(C)C)C[C@H]12

$$$$
SWF004630
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.0532   -6.1970   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -6.1970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -4.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -5.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -4.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -4.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004630

>  <SMILES>
O=C1CC2C(CCN2C(=O)c2ccnc(F)c2)N1CC1CC1

$$$$
SWF004631
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004631

>  <SMILES>
Cn1cnc(C(=O)N2CCO[C@H]3[C@H](Oc4cccnc4)CC[C@@H]32)n1

$$$$
SWF004632
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
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 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
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 17 18  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004632

>  <SMILES>
Cn1cnc(C(=O)N2CCCC3(CC(C(=O)Nc4ccccc4)=NO3)C2)n1

$$$$
SWF004633
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  2  0  0  0  0
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 16 19  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
  4  5  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004633

>  <SMILES>
O=C(Nc1ccc2c(c1)C1(CCOCC1)C(=O)N2c1ccsc1)c1cc[nH]c1

$$$$
SWF004634
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
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  4  9  1  0  0  0  0
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  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004634

>  <SMILES>
CN1CCC2(CCCN(C(=O)Cc3ccccc3)CC2)C1=O

$$$$
SWF004635
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004635

>  <SMILES>
O=C(c1cc[nH]n1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF004636
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
  9 11  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004636

>  <SMILES>
Cc1nc(CN2C(=O)C[C@H]3[C@@H]2CCN3CC2CCCCC2)cs1

$$$$
SWF004637
Actelion Java MolfileCreator 1.0

 33 38  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 29 31  1  0  0  0  0
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 31 33  1  0  0  0  0
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M  END
>  <HTSID>
SWF004637

>  <SMILES>
Cc1ccc2nc(CN3C(=O)C[C@H]4[C@@H]3CCN4Cc3ccnc(N4CCOCC4)c3)cn2c1

$$$$
SWF004638
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -2.3975   -7.3263   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6401   -8.6382   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004638

>  <SMILES>
CNC(=O)C1(n2cccn2)CCCN(C(=O)c2cscn2)C1

$$$$
SWF004639
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004639

>  <SMILES>
CC(C)N1C[C@@H]2[C@H](NC(=O)C(C)(C)C)c3ccccc3[C@@H]2C1

$$$$
SWF004640
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    0.5158    2.2433   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5103    2.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    1.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 22 23  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004640

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccco1)C2

$$$$
SWF004641
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 11 15  2  0  0  0  0
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 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004641

>  <SMILES>
CCCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccccn1)C2

$$$$
SWF004642
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF004642

>  <SMILES>
CCN1c2cccnc2-n2cccc2C12CCN(C(=O)C1CCC1)C2

$$$$
SWF004643
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004643

>  <SMILES>
O=C(NCc1cscn1)C1=NOC2(CCCN(Cc3ccccn3)C2)C1

$$$$
SWF004644
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004644

>  <SMILES>
CCN1CCOC2CN(C(=O)c3csc(C)n3)CCC2C1

$$$$
SWF004645
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004645

>  <SMILES>
Cc1nnc([C@@H]2CCO[C@@H]3CCN(C(=O)c4cc[nH]n4)C[C@@H]32)o1

$$$$
SWF004646
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004646

>  <SMILES>
Cn1nccc1C(=O)N1CCCC2(CCN(c3cncnc3)C2=O)C1

$$$$
SWF004647
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004647

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2[C@@H]1CCN2C(=O)Cc1ccc(F)cn1

$$$$
SWF004648
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004648

>  <SMILES>
Cc1cnc(N2CCC3(CC3C(=O)N3CCOCC3)C2)nc1

$$$$
SWF004649
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004649

>  <SMILES>
O=C(C1CC(O)C1)N1CCO[C@H]2[C@@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF004650
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004650

>  <SMILES>
CCS(=O)(=O)NCC1CN(Cc2ccccc2)Cc2ccnn21

$$$$
SWF004651
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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 18 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  9 11  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004651

>  <SMILES>
O=C(NCC1CCC2(CCN(c3ncccn3)CC2)CO1)c1cccc(C(F)(F)F)c1

$$$$
SWF004652
Actelion Java MolfileCreator 1.0

 19 21  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 17 19  2  0  0  0  0
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 11 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF004652

>  <SMILES>
CS(=O)(=O)N1CC2CCN(C(=O)c3ccsc3)C2C1

$$$$
SWF004653
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004653

>  <SMILES>
O=C1CCC2(CCN(C(=O)Cc3cccc(F)c3)CC2)CN1

$$$$
SWF004654
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004654

>  <SMILES>
O=C(/C=C/c1cccs1)N1CC[C@H]2[C@H]1CCN2Cc1cccnc1

$$$$
SWF004655
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1794   -2.7295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004655

>  <SMILES>
CC(c1ccccc1)N1CC2(COCCN(CC(=O)N3CCCC3)C2)CC1=O

$$$$
SWF004656
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
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  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004656

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCCC3(CCNC3=O)CC2)c1

$$$$
SWF004657
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004657

>  <SMILES>
CCN1CCNC(=O)C12CCN(C(=O)Cc1ccc(F)cn1)CC2

$$$$
SWF004658
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004658

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF004659
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  7  4  1  1  0  0  0
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  8 10  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 26  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004659

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(NC(=O)N(C)C)CO2

$$$$
SWF004660
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.8570   -4.5750   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 21 23  1  0  0  0  0
 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <HTSID>
SWF004660

>  <SMILES>
CCN(C)C(=O)c1cnn2c1CN(C(=O)c1cc[nH]n1)CCC2

$$$$
SWF004661
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004661

>  <SMILES>
Cc1ccc(CC(=O)N2CCC(C3CCCCN3C)CC2)cc1

$$$$
SWF004662
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004662

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2CN(C(=O)c3cccc(F)c3)C[C@@H]21

$$$$
SWF004663
Actelion Java MolfileCreator 1.0

 19 21  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004663

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2CN(C(=O)c3cccs3)C[C@@H]21

$$$$
SWF004664
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.2497   -4.3738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004664

>  <SMILES>
O=C(c1cc[nH]n1)N1CC[C@@H]2CN(CC3CC3)CCO[C@@H]2C1

$$$$
SWF004665
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004665

>  <SMILES>
CC(C)N1CCOC2CN(C(=O)c3cc(F)ncc3F)CCC2C1

$$$$
SWF004666
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004666

>  <SMILES>
C=C(C)CN1c2cccnc2-n2cccc2C12CCN(C(=O)C1CCC1)C2

$$$$
SWF004667
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 17 23  1  0  0  0  0
 18 24  1  0  0  0  0
 19 25  1  0  0  0  0
 21 26  1  0  0  0  0
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 23 28  1  0  0  0  0
 26 29  2  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
  8  9  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  2  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004667

>  <SMILES>
CC(C)CCN1c2cccnc2-n2cccc2C12CCN(C(=O)Cc1ccccn1)C2

$$$$
SWF004668
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004668

>  <SMILES>
CS(=O)(=O)NCC1CN(C2CCOCC2)Cc2ccnn21

$$$$
SWF004669
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2160    1.1086   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004669

>  <SMILES>
CN(C)CC1CCn2nccc2CN1C(=O)c1ccn(C)n1

$$$$
SWF004670
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.7510   -2.4241   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004670

>  <SMILES>
Cc1nc(C(=O)N2CC3CC(C(=O)NCC(C)C)C(C2)O3)cs1

$$$$
SWF004671
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.0526   -3.1014   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004671

>  <SMILES>
CC(C)CNC(=O)C1CC2CN(C(=O)C3CC(F)(F)C3)CC1O2

$$$$
SWF004672
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004672

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(CC(C)C)C3)C2)c1

$$$$
SWF004673
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004673

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCC3(CC2)NC(=O)[C@@H]2CN(CC(C)C)C[C@@H]23)cc1

$$$$
SWF004674
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    8.7629    0.9076   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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M  END
>  <HTSID>
SWF004674

>  <SMILES>
CCc1ccc(C(=O)N2CC3CC(C(=O)NCC(C)C)C(C2)O3)cn1

$$$$
SWF004675
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
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 12 13  1  0  0  0  0
 22 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF004675

>  <SMILES>
O=C(C1CC(F)C1)N1CC[C@@H](OCC2CC2)[C@H](Cc2ccccc2)C1

$$$$
SWF004676
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF004676

>  <SMILES>
CCCN1C[C@H]2C(=O)NC3(CCN(C(=O)Cc4ccccc4Cl)CC3)[C@H]2C1

$$$$
SWF004677
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.9020   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
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 13 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004677

>  <SMILES>
CCCN1C[C@H]2C(=O)NC3(CCN(C(=O)c4cccc(C)c4)CC3)[C@H]2C1

$$$$
SWF004678
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6  9  1  0  0  0  0
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 11 15  1  1  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004678

>  <SMILES>
CO[C@@H]1CCN(C(=O)CCc2ccc[nH]2)C[C@H]1Cc1ccccc1

$$$$
SWF004679
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 14 15  2  0  0  0  0
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 18 20  1  0  0  0  0
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 26 28  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004679

>  <SMILES>
O=C(c1cc[nH]n1)N1CCOC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF004680
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   12.2294    3.3107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    4.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313    0.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333    0.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF004680

>  <SMILES>
Cn1cc(N2CC3(CCCN(Cc4ccncc4)C3)C2=O)ccc1=O

$$$$
SWF004681
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 15 19  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004681

>  <SMILES>
O=C(CC1CCOCC1)N1C[C@@H]2OCCN(c3ccccn3)[C@H]2C1

$$$$
SWF004682
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004682

>  <SMILES>
Cc1ccc(CN2Cc3ccnn3C(CNS(C)(=O)=O)C2)cc1

$$$$
SWF004683
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6939   -2.3647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 12 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004683

>  <SMILES>
Cn1cnc(C(=O)N2C[C@H]3CCN(Cc4cccnc4)CC[C@H]3C2)c1

$$$$
SWF004684
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.8615   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9955   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955   -5.0777   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004684

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(C(=O)c3cc[nH]c3)C[C@H]2O1)NC1CC1

$$$$
SWF004685
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1549    2.8786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8071    1.9890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3459    4.2799   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3177    3.6413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004685

>  <SMILES>
CNC(=O)C1CCCC12CCN(C(=O)c1c(C)noc1C)C2

$$$$
SWF004686
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0850   -3.9199   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
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 23 24  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004686

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(C(=O)NC2CCC2)=NO3)cn1

$$$$
SWF004687
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
   -0.3859    0.3183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0209    1.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 15  2  0  0  0  0
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 22 27  1  0  0  0  0
 22 28  1  0  0  0  0
 25 29  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004687

>  <SMILES>
CC(C)CN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccccn1)C2

$$$$
SWF004688
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.0782    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5782    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004688

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3C[C@@H](CC(=O)N4CCC4)O[C@@H]3C2)cs1

$$$$
SWF004689
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004689

>  <SMILES>
O=C(c1ccsc1)N1CCC2(CCCC2C(=O)N2CC(F)(F)C2)C1

$$$$
SWF004690
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004690

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)c3ccsc3)C[C@H]12)N1CCCC1

$$$$
SWF004691
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004691

>  <SMILES>
Cn1nccc1C(=O)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF004692
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004692

>  <SMILES>
Cc1noc(C)c1C(=O)N1CCC(C2CCCCN2S(C)(=O)=O)CC1

$$$$
SWF004693
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004693

>  <SMILES>
CC(CNC(=O)C1=NOC2(CCN(C(=O)NC3CC3)C2)C1)c1ccccc1

$$$$
SWF004694
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF004694

>  <SMILES>
O=C(c1ccccc1)N1CCOC2(C1)C(=O)N(CC1CCOCC1)CC2c1ccccc1

$$$$
SWF004695
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.7596    3.0823   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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 11 14  1  0  0  0  0
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 10 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF004695

>  <SMILES>
CN(C)C(=O)[C@@]12CCO[C@@H]1CCN(C(=O)CC1(O)CCC1)C2

$$$$
SWF004696
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004696

>  <SMILES>
O=C(NC1CCC1)C1=NOC2(CCN(C(=O)c3cccc(F)c3)CC2)C1

$$$$
SWF004697
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 13  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004697

>  <SMILES>
CN(C)C(=O)[C@@]12CCO[C@@H]1CCN(C(=O)CCc1cncnc1)C2

$$$$
SWF004698
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004698

>  <SMILES>
Cn1cnc(C(=O)N2CCc3ncnc(-c4ccncc4)c3C2)n1

$$$$
SWF004699
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004699

>  <SMILES>
O=C(Cc1ccccc1)N1CC2(CCC(CN3CCOCC3)CO2)C1

$$$$
SWF004700
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004700

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)Cc3cccc(F)c3)CC2)C1)c1cccnc1

$$$$
SWF004701
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  7 12  1  0  0  0  0
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 10 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004701

>  <SMILES>
CC(C)NC(=O)C1CN(C(=O)c2ccccc2)C2CCOC12

$$$$
SWF004702
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004702

>  <SMILES>
CN1CC2(CCC1=O)CCN(C(=O)c1cccc(F)c1)CC2

$$$$
SWF004703
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   15.3644   -2.7546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004703

>  <SMILES>
COCCN1CCC2(CC1)CN(C(=O)c1ccsc1)CCO2

$$$$
SWF004704
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    8.6451   -2.5092   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3461   -1.7592   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3040    0.7363   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1240   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  2  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004704

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)C4[C@H]5COC[C@@H]45)C3)CC2=O)cc1

$$$$
SWF004705
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004705

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)C4(F)CC4)C3)CC2=O)cc1

$$$$
SWF004706
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  7 10  2  0  0  0  0
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  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004706

>  <SMILES>
CN(C)C1CCOC2(CCN(C(=O)Cc3ccccn3)CC2)C1

$$$$
SWF004707
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    1.9997    6.6361   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2368    5.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 26 29  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004707

>  <SMILES>
O=C(Cc1cccc(O)c1)N1CCCC2(CCCN2Cc2ccc(F)cc2)CC1

$$$$
SWF004708
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004708

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(N(C)C)C2

$$$$
SWF004709
Actelion Java MolfileCreator 1.0

 22 23  0  0  1  0  0  0  0  0999 V2000
    7.9771    2.7034   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3893    3.5125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7960    4.4260   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3948    3.4079   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7905    4.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9880    2.4944   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3464    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 10 11  1  1  0  0  0
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 13 15  1  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF004709

>  <SMILES>
CC(C)N(C)CC(=O)N1CC[C@]2(C1)C[C@@H](NC(=O)N(C)C)C2

$$$$
SWF004710
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.7942    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7648   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5738   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7429   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2429   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8543   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004710

>  <SMILES>
COCCNC(=O)[C@@H]1CN(C(=O)c2cc[nH]c2)C[C@H]2OCC[C@H]21

$$$$
SWF004711
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5409   -4.7510   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7978   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8467   -4.3909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7713   -4.3909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4623   -5.3419   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004711

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)c3cc[nH]n3)C[C@H]12)N1CCCC1

$$$$
SWF004712
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    9.0466    1.2436   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646    0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646   -0.7568   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1754   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539   -1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8646    2.2703   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2431    2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3130    1.7892   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0228    3.7756   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323    1.5136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2601    2.7795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5033    4.0903   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9323   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3108   -3.0271   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6215   -2.2703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004712

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)Cc2ccccn2)CC1

$$$$
SWF004713
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   15.2370    0.5471   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.9380    1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9380    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    0.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6390    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    1.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    0.5471   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    5.0471   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0691    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  6  8  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 16 17  2  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004713

>  <SMILES>
CN(C)C(=O)c1nc2c(s1)CCN(C(=O)c1cnc(Cl)cc1Cl)CC2

$$$$
SWF004714
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1643    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5711   -0.8907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0711   -1.7567   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5492   -1.0986   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7402   -2.4999   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004714

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CC(C(=O)NC2CCC2)=NO3)n1

$$$$
SWF004715
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 10 15  2  0  0  0  0
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 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004715

>  <SMILES>
O=C(Cc1ccccc1)NC1CC2(CCN(c3ncccn3)CC2)Oc2ccccc21

$$$$
SWF004716
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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M  END
>  <HTSID>
SWF004716

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CCn3ncnc3C2NC(=O)c2cccs2)C1

$$$$
SWF004717
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004717

>  <SMILES>
O=C(NC1CC2CC1CN2Cc1cccnc1)c1cccc(F)c1

$$$$
SWF004718
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004718

>  <SMILES>
O=C1CCC2(CCCN(Cc3cccc(F)c3)CC2)N1CCF

$$$$
SWF004719
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.1909    3.2327   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  2  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 12  1  6  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004719

>  <SMILES>
O=C(Nc1cccnc1)[C@@H]1CO[C@@H]2CN(C(=O)Cc3ccccc3)C[C@@H]21

$$$$
SWF004720
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7212   -0.6886   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 14 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004720

>  <SMILES>
c1cncc(OC2CSC3(C2)CN(C2CCOCC2)C3)c1

$$$$
SWF004721
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 22  1  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004721

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)c3cccs3)C[C@H]12)N1CCCC1

$$$$
SWF004722
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004722

>  <SMILES>
COCC12CCCOC1CCN(C(=O)Cc1ccc(F)cn1)C2

$$$$
SWF004723
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 10 13  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004723

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(C(=O)NC2CC2)=NO3)cn1

$$$$
SWF004724
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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   -6.4063   -4.0981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4063   -4.0981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1563   -5.3971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6563   -5.3971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.9063   -4.0981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4063   -6.6962   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  7  8  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004724

>  <SMILES>
CC1CC(C)CN(C(=O)c2nc3c(o2)CCN(Cc2ccccc2F)C3)C1

$$$$
SWF004725
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109    1.4672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027    1.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128    0.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1027    4.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6027    4.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6027    1.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3527    2.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  2  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004725

>  <SMILES>
O=C(Cc1cccc(O)c1)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF004726
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.1312    3.1740   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8740   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8740   -9.0488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -7.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -9.0488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  1  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
  5  6  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004726

>  <SMILES>
Cc1ccccc1CN1CCc2oc(C(=O)N[C@@H]3CC[C@@H](F)C3)nc2C1

$$$$
SWF004727
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0249   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -6.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -6.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004727

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CC2)CC(N(C)C)C3)cc1

$$$$
SWF004728
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -3.7418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -4.0537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2341   -5.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004728

>  <SMILES>
CNC(=O)C1(Nc2ccn(C)n2)CCN(C(=O)c2cccc(C)c2)CC1

$$$$
SWF004729
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3018   -0.2530   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4511   -0.7787   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5258   -0.3995   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3764   -1.7759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2887    0.5720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049   -2.0130   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5139   -0.2314   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5583    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3904   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004729

>  <SMILES>
COc1ccc(CN2CCCC3(CCC(=O)N3C)CC2)cc1

$$$$
SWF004730
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  1  6  0  0  0
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 21 24  1  0  0  0  0
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 25 26  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004730

>  <SMILES>
C=CCOC1CC2(CCN(C(=O)C3CC(O)C3)CC2)c2cc(C)ccc21

$$$$
SWF004731
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004731

>  <SMILES>
CO[C@@H]1CCN(C(=O)C2CC(C)C2)C[C@H]1Cc1ccccc1

$$$$
SWF004732
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  2  0  0  0  0
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 15 17  1  1  0  0  0
 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004732

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2c2cc(C(F)(F)F)ncn2)N1Cc1cccc(F)c1F

$$$$
SWF004733
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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 20 22  1  0  0  0  0
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 21 24  3  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
  7  9  1  0  0  0  0
 13 14  1  6  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004733

>  <SMILES>
N#CC1(C(=O)N2C[C@H](Oc3ncccc3F)[C@H]3OCCC[C@H]32)CCCC1

$$$$
SWF004734
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    8.8912    1.5394   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF004734

>  <SMILES>
CCC(CC)CN1CCCC(C(=O)N(C)C)(n2cccn2)C1

$$$$
SWF004735
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.8690    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2812    1.3090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2593   -0.5169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5931   -4.2836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
  5  6  2  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004735

>  <SMILES>
CN(C)C(=O)c1ccc2c(c1)C1(CCN(C(=O)c3cc[nH]c3)CC1)C(=O)N2

$$$$
SWF004736
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7226   -3.3966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6861   -5.3646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004736

>  <SMILES>
CCn1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NC)C2)cn1

$$$$
SWF004737
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004737

>  <SMILES>
CC(C)N1[C@H](CN(C)C)C[C@@H]2CN(C(=O)Cc3ccc(F)cn3)CC[C@@H]21

$$$$
SWF004738
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0224    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1214   -1.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2501   -3.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 18 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
 27 30  2  0  0  0  0
 16 20  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF004738

>  <SMILES>
COc1ncccc1-c1nnn2c1COCC(CNC(=O)CCc1cncnc1)C2

$$$$
SWF004739
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.0963    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5622    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004739

>  <SMILES>
O=C([C@@H]1CO[C@@H]2CCN(C(=O)C3(F)CC3)C[C@@H]2C1)N1CCCC1

$$$$
SWF004740
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.5298   -4.0818   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 18 21  1  0  0  0  0
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 20 23  1  0  0  0  0
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 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004740

>  <SMILES>
Cc1ccc(CN2C(=O)C[C@H]3[C@@H]2CCN3CCC(C)C)cc1C

$$$$
SWF004741
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7117    1.1094   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3464    0.1786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3575    0.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7341    0.8114   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9922   -0.9014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6045   -1.5341   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0034   -1.0504   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2280   -2.3160   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2452    1.5283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004741

>  <SMILES>
C=CCN1CCOC2CN(C(=O)c3ccc(O)nn3)CCC2C1

$$$$
SWF004742
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
   11.2788   -1.7024   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7788   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  7  8  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004742

>  <SMILES>
COC[C@H](C)NC(=O)c1nc2c(o1)CCN(Cc1ccccc1F)C2

$$$$
SWF004743
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7  9  2  0  0  0  0
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 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004743

>  <SMILES>
O=C(c1cccc(Cl)n1)N1CCC2(CC1)CN(c1cncnc1)C(=O)CO2

$$$$
SWF004744
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    3.2759   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004744

>  <SMILES>
O=C1NC2(CCN(C(=O)c3ccccc3)CC2)[C@H]2CN(CC3CC3)C[C@@H]12

$$$$
SWF004745
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004745

>  <SMILES>
CS(=O)(=O)N1CCO[C@@H]2CN(C(=O)Cn3cc(Cl)cn3)C[C@@H]2C1

$$$$
SWF004746
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    9.5925   -5.5136   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004746

>  <SMILES>
Cc1ccccc1C(=O)NC1CCc2onc(CN(C)C)c2C1

$$$$
SWF004747
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004747

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CC[C@H]2C(=O)N(Cc3ccncc3)CCO[C@H]2C1

$$$$
SWF004748
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004748

>  <SMILES>
O=C(NC1c2ncnn2CCC12CCN(C(=O)c1ccco1)C2)c1ccccc1

$$$$
SWF004749
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004749

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCc2nnc(COc3ccccn3)n2CC1

$$$$
SWF004750
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    3.0020   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    3.0020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    3.9531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8380    2.6930   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0949    3.3621   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8562    3.0531   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5993    3.7222   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0641    2.0749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5504    3.4132   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0152    1.7659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7583    2.4351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004750

>  <SMILES>
CC(C)CC(=O)N1CC2(C1)OCCC2COc1cccnc1

$$$$
SWF004751
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -6.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
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 13 18  1  6  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 13  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004751

>  <SMILES>
CC(C)N(C)CC(=O)N1CC[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF004752
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1270   -0.1347   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1811    0.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4218    0.8209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8613    1.7219   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8585    1.6472   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004752

>  <SMILES>
CN(C)CCN1CCOC2CCN(c3ncccn3)CCC21

$$$$
SWF004753
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6532    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0352    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6285    2.4343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2163    3.2433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
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 14 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
  9 11  1  0  0  0  0
 13 19  1  0  0  0  0
 15 20  1  0  0  0  0
 22 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004753

>  <SMILES>
Cc1cccc(-c2ccc3c(c2)C2(CCOCC2)CN3C(=O)c2cccc(O)c2)c1

$$$$
SWF004754
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.5038    0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0058    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0521    0.0871   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5038   -1.5020   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5038    1.5020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2030   -2.2530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2030   -3.7550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2030   -0.7510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9023   -3.0040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8396   -1.8131   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  2  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004754

>  <SMILES>
CS(=O)(=O)N1CCOCC12CCN(C(=O)C1(F)CCC1)CC2

$$$$
SWF004755
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 23 27  1  0  0  0  0
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M  END
>  <HTSID>
SWF004755

>  <SMILES>
N#CC1(C(=O)N2CC[C@]3(C2)C(=O)NC[C@H]3COc2cccnc2)CCCC1

$$$$
SWF004756
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 17 19  1  0  0  0  0
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 27 28  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004756

>  <SMILES>
COc1ccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NCc3ccon3)C2)cc1

$$$$
SWF004757
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.5602   -0.8896   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF004757

>  <SMILES>
COCC1CN(Cc2cccs2)CC12CCN(Cc1ccco1)CC2

$$$$
SWF004758
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004758

>  <SMILES>
COCCNC(=O)C1(n2ccnc2)CCN(Cc2cccs2)CC1

$$$$
SWF004759
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004759

>  <SMILES>
O=C1c2cccn2C2CN(Cc3ccccc3F)CC2N1Cc1ccccn1

$$$$
SWF004760
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 17 18  1  6  0  0  0
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 21 23  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004760

>  <SMILES>
CC(C)C(=O)NC1COC2(CCN(C(=O)c3csnn3)CC2)C1

$$$$
SWF004761
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  2  0  0  0  0
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 16 19  1  0  0  0  0
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 17 21  2  0  0  0  0
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 18 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004761

>  <SMILES>
CC(C)CC(=O)N1CC2(CC(Oc3cccnc3)CS2)C1

$$$$
SWF004762
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.0563    6.6782   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004762

>  <SMILES>
CNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cccs2)CC1

$$$$
SWF004763
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004763

>  <SMILES>
CN1C[C@]2(COCC1=O)CN(C(=O)Cc1ccc(F)cn1)C[C@H]2N(C)C

$$$$
SWF004764
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
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M  END
>  <HTSID>
SWF004764

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCC2(CC1)CN(Cc1nccs1)CCO2

$$$$
SWF004765
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  6  0  0  0
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  5  6  1  0  0  0  0
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M  END
>  <HTSID>
SWF004765

>  <SMILES>
COCCNC(=O)[C@H]1CN(C(=O)c2cccs2)[C@@H]2CCO[C@H]12

$$$$
SWF004766
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 16  2  0  0  0  0
 11 17  1  0  0  0  0
 11 18  1  0  0  0  0
 13 19  2  0  0  0  0
 15 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
  9 11  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 22 24  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004766

>  <SMILES>
Cc1ccc(-c2ccc3c(c2)C2(CCOCC2)CN3C(=O)c2ccccc2O)cc1

$$$$
SWF004767
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004767

>  <SMILES>
O=C(NCC1OCCc2cn(Cc3ccccc3)nc21)c1ccccc1O

$$$$
SWF004768
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 12 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 16 19  1  0  0  0  0
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 18 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004768

>  <SMILES>
CCN1C(=O)CCCC12CCCN(C(=O)c1sccc1C)C2

$$$$
SWF004769
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.1104    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004769

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC[C@H](O)[C@@H]2Cc2ccccc2)n[nH]1

$$$$
SWF004770
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    7.1762    2.6405   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6282   -3.5295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
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 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
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 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 21 24  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF004770

>  <SMILES>
O=C(c1ccccc1O)N1CC2(CCOCC2)c2cc(-c3cccc(F)c3)ccc21

$$$$
SWF004771
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  2  5  1  0  0  0  0
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  6  7  1  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
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 18 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004771

>  <SMILES>
Cc1ccc(N2CC3(CCN(C(=O)c4csc(C)n4)C3)CC2=O)cc1

$$$$
SWF004772
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004772

>  <SMILES>
O=C1CC2(COCCN(Cc3cccc(F)c3)C2)CN1c1ccc(F)cc1

$$$$
SWF004773
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
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 14 19  1  6  0  0  0
 16 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004773

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cccc(C)n2)[C@@H]2CN(CC3CC3)C[C@@H]21

$$$$
SWF004774
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004774

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCCN(Cc2ccc(F)cc2)C1

$$$$
SWF004775
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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   -3.5314   -3.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3404   -4.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7224   -4.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0314   -5.0777   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0314   -5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004775

>  <SMILES>
Cc1nc(CN2CC3CN(C(=O)c4cc[nH]c4)CC3C2)cs1

$$$$
SWF004776
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    9.6843    2.0672   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.8027    0.8536   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1109    1.6036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.1025   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  4  5  1  0  0  0  0
  9 11  2  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 27  2  0  0  0  0
M  END
>  <HTSID>
SWF004776

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CCc3ncc(-c4ccsc4)n3C2)CC1

$$$$
SWF004777
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4148   -6.0895   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5838   -6.1418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
 15 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004777

>  <SMILES>
CC(C)n1nc(CNS(C)(=O)=O)c2c1CN(C(=O)C1(F)CCC1)CC2

$$$$
SWF004778
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    6.0351   -4.6476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3689   -3.1852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8313   -2.8515   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4821   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7665   -4.0242   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2498   -3.8006   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3689    0.1852   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3882   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004778

>  <SMILES>
O=C(C1CC(O)C1)N1CC[C@H]2C(=O)N(Cc3ccncc3)CCO[C@H]2C1

$$$$
SWF004779
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.2562   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6624   -1.4976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6938   -2.4731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6511   -2.6321   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0225   -2.9336   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2743   -4.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004779

>  <SMILES>
Cn1cnc(S(=O)(=O)N2CCOC3CCC2C3Oc2ncccc2F)c1

$$$$
SWF004780
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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    5.0544    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004780

>  <SMILES>
CC(C)C(=O)N1CC2(CC(OCC(=O)N(C)C)CS2)C1

$$$$
SWF004781
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004781

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3CN(C(=O)c4ccccc4)CCO[C@@H]3C2)cs1

$$$$
SWF004782
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004782

>  <SMILES>
O=C(NCc1ccccn1)[C@@H]1C[C@@H]2CCN(C(=O)c3cc[nH]n3)C[C@H]2O1

$$$$
SWF004783
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004783

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(C(=O)NCc4ccccc4C)C[C@@H]32)C(=O)N1

$$$$
SWF004784
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF004784

>  <SMILES>
N#CC1(C(=O)N2CCCC3(CCN(c4ccsc4)C3=O)C2)CCCC1

$$$$
SWF004785
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004785

>  <SMILES>
CC(C)Oc1ccccc1CN1CC[C@H]2[C@@H]1CC(=O)N2Cc1cc(F)cc(F)c1

$$$$
SWF004786
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004786

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)c3csnn3)C[C@H]12)N1CCCC1

$$$$
SWF004787
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004787

>  <SMILES>
Fc1ccc(-c2cnc3n2CC2(CCN(Cc4ccsc4)C2)OC3)cc1

$$$$
SWF004788
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004788

>  <SMILES>
O=C(Nc1cccnc1)c1ncn2c1CN(C(=O)c1cc[nH]n1)CCC2

$$$$
SWF004789
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004789

>  <SMILES>
CC(C)CN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccco1)C2

$$$$
SWF004790
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004790

>  <SMILES>
C=CCOc1ccc(C(=O)N2C[C@@H]3C[C@H](CC(=O)NC)O[C@@H]3C2)cc1

$$$$
SWF004791
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 12 11  1  1  0  0  0
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M  END
>  <HTSID>
SWF004791

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)c3cc[nH]c3)C[C@H]12)N1CCOCC1

$$$$
SWF004792
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004792

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(C(=O)c3ncn(C)n3)CC2)C1

$$$$
SWF004793
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004793

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CC[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF004794
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004794

>  <SMILES>
Cc1cncc(C(=O)N2CC3(CC(OCc4ccccn4)CS3)C2)c1

$$$$
SWF004795
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 10 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF004795

>  <SMILES>
O=C(c1cc[nH]n1)N1CC[C@H]2[C@H]1CCN2S(=O)(=O)C1CC1

$$$$
SWF004796
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004796

>  <SMILES>
O=C(c1csnn1)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF004797
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004797

>  <SMILES>
CC1CC(C(=O)N2CC[C@@H]3OCCN(S(=O)(=O)C4CC4)[C@H]3C2)C1

$$$$
SWF004798
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1366   -4.1292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1325   -2.1630   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  1  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004798

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H](N(C)C)[C@@]3(COCC(=O)N(C)C3)C2)cs1

$$$$
SWF004799
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 17 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 16 20  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004799

>  <SMILES>
CC(C)N1CCn2cc(C(=O)NCc3ccccn3)nc2C1C

$$$$
SWF004800
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004800

>  <SMILES>
CS(=O)(=O)NCCC1CCOC12CN(C(=O)c1ccoc1)C2

$$$$
SWF004801
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5665   -1.9160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0665   -2.7820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8745   -4.7136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0556   -2.9910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8691   -4.8181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4568   -4.0091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  7  2  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004801

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(Cc4ccccc4)C[C@@H]32)C(=O)N1CC1CC1

$$$$
SWF004802
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004802

>  <SMILES>
C[C@@H]1CN(C(=O)C2CCOC2)C[C@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF004803
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9843    4.9810   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2252    7.3786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  6  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004803

>  <SMILES>
Cc1c(C(=O)N2C[C@@H]3CN(C)CCO[C@@H]3C2)nc2ccccn12

$$$$
SWF004804
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    8.2196    3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    3.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004804

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@@H]2CCN(C(=O)c3ccsc3)C[C@H]2O1

$$$$
SWF004805
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 20 16  1  1  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  6  0  0  0
 23 25  1  6  0  0  0
 24 26  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004805

>  <SMILES>
C[C@@H]1CN(C(=O)[C@H]2[C@@H]3COC[C@@H]32)C[C@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF004806
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4489   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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  7  8  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004806

>  <SMILES>
Cn1cc(CN2CC[C@]3(C2)C[C@H](NS(=O)(=O)C2CC2)C3)cn1

$$$$
SWF004807
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.6974   -3.0240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8158   -4.2376   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -4.0808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5278   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
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 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004807

>  <SMILES>
CO[C@H]1CO[C@]2(CCCN(C(=O)c3ccc4c(ccn4C)c3)C2)C1

$$$$
SWF004808
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004808

>  <SMILES>
Cc1noc(C)c1C(=O)N1CCC2(CCCC2C(=O)N(C)C)C1

$$$$
SWF004809
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 23 25  2  0  0  0  0
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M  END
>  <HTSID>
SWF004809

>  <SMILES>
O=C(NCc1cccnc1)C1=NO[C@@H]2CN(C(=O)c3cccs3)C[C@H]12

$$$$
SWF004810
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004810

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)CN(C(=O)c1ccccc1)CCO2

$$$$
SWF004811
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004811

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CC3OCCN(S(C)(=O)=O)C3C2)c1

$$$$
SWF004812
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    2.3749    3.1250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
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 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004812

>  <SMILES>
CCc1ccc(C(=O)N2C[C@@H](N(C)C)[C@@]3(COCC(=O)N(C)C3)C2)cn1

$$$$
SWF004813
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.6941   -1.1030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9020   -0.1248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8531    0.1842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5962   -0.4849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0610    1.1624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634    1.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    1.9456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 16 17  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10  9  1  1  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004813

>  <SMILES>
CN(C)C(=O)C1=NO[C@@H]2CN(C(=O)Cc3ccccn3)C[C@H]12

$$$$
SWF004814
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.3601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529    0.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -0.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202    1.0537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6246   -5.2411   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  1  6  0  0  0
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  5 10  1  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 24  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004814

>  <SMILES>
Cn1nccc1[C@H]1CNC[C@@]12CCCN(Cc1ccccc1)C2=O

$$$$
SWF004815
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3412   -3.6691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9400   -4.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9345   -4.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -6.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7872   -4.8799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1691   -6.7820   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4563   -5.6230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  9  1  1  0  0  0
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 10 13  1  1  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 19 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004815

>  <SMILES>
CN(C)C(=O)[C@H]1C[C@H]2OCC[C@H]2N(Cc2cn(C)c3ncccc23)C1

$$$$
SWF004816
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004816

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCC3(CC2)CC(N(C)C)C3)c1

$$$$
SWF004817
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.6066   -2.6351   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8238   -1.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.2796   -3.8897   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   15.5787   -3.1397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004817

>  <SMILES>
COc1cc(C(=O)N2CCC3(CC2)CC(C(=O)NC2CC2)=NO3)on1

$$$$
SWF004818
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004818

>  <SMILES>
CN1CC(COCc2cccnc2)CC12CN(C(=O)C1CC(O)C1)C2

$$$$
SWF004819
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 25 27  2  0  0  0  0
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 16 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004819

>  <SMILES>
O=C(COc1ccccc1)N1CCC2(CC1)CN(c1cccc(F)c1)C2=O

$$$$
SWF004820
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 17 18  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004820

>  <SMILES>
O=C(c1cscn1)N1CCC2(CC1)CN(Cc1ccccc1)C2=O

$$$$
SWF004821
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF004821

>  <SMILES>
Cn1ccnc1CN1CCC2(CC1)CN(c1ccccc1)C2=O

$$$$
SWF004822
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004822

>  <SMILES>
CN1C(=O)C2(CCN(Cc3cccnc3)CC2)C1c1ccccc1

$$$$
SWF004823
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.1529   -2.2071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9300   -0.3752   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004823

>  <SMILES>
O=C(c1ccccn1)N1CCC2(CC1)CN(c1cccc(F)c1)C2=O

$$$$
SWF004824
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9300    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004824

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccncc3)CC2)C1=O

$$$$
SWF004825
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004825

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CC1)CN(CC1CC1)C2=O

$$$$
SWF004826
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 14  2  0  0  0  0
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  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004826

>  <SMILES>
O=C(c1ccccn1)N1CCC2(CC1)CN(c1cccnc1)C2=O

$$$$
SWF004827
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004827

>  <SMILES>
Cn1cc(CN2CCC3(CC2)CN(c2ccccc2)C3=O)cn1

$$$$
SWF004828
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7961   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    3.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    4.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    4.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004828

>  <SMILES>
O=C(NC1CC1)N1CCC2(CC1)CN(Cc1cccnc1)C2=O

$$$$
SWF004829
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9300   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4300    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9300    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  8 12  1  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004829

>  <SMILES>
Cn1cc(CN2CCC3(CC2)C(=O)NC3c2ccccc2)cn1

$$$$
SWF004830
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3344   -2.6138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0036   -1.8707   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5036   -1.0047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004830

>  <SMILES>
O=C1N(Cc2cccnc2)CC12CCN(Cc1ccoc1)CC2

$$$$
SWF004831
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004831

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(Cc1ccsc1)CC2

$$$$
SWF004832
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004832

>  <SMILES>
O=C(c1ccco1)N1CCC2(CC1)CN(c1ccccc1)C2=O

$$$$
SWF004833
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9863   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7970   -0.5627   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.0333   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.4352   -7.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342   -8.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004833

>  <SMILES>
O=C1N(Cc2cccnc2)CC12CCN(Cc1ccc(F)cc1)CC2

$$$$
SWF004834
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4209   -4.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  2  0  0  0  0
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  8 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004834

>  <SMILES>
O=C1N(c2cccnc2)CC12CCN(Cc1ccncc1)CC2

$$$$
SWF004835
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4325   -4.9979   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1825   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6313   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2431   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2294   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2294   -6.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5285   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  2  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004835

>  <SMILES>
CCC(CC)CN1CCC2(CC1)CN(c1cccnc1)C2=O

$$$$
SWF004836
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2229   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9300   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4300    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9300    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004836

>  <SMILES>
O=C1NC(c2ccccc2)C12CCN(CC1CCOCC1)CC2

$$$$
SWF004837
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9300    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0665   -2.6138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2575   -1.2126   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7356   -1.8707   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2744   -3.5920   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2356   -1.0047   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 21  1  0  0  0  0
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 11 13  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004837

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cnoc3C)CC2)C1=O

$$$$
SWF004838
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9300    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190   -2.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0190   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8850   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
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  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004838

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccccn3)CC2)C1=O

$$$$
SWF004839
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9550   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4550   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1621   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6621   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1621    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6621    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6621    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 11 14  1  0  0  0  0
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 16 18  2  0  0  0  0
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  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004839

>  <SMILES>
CC(C)NC(=O)N1CCC2(CC1)C(=O)NC2c1ccccc1

$$$$
SWF004840
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6  9  1  0  0  0  0
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  9 12  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004840

>  <SMILES>
O=C1N(Cc2cccnc2)CC12CCN(c1ncccn1)CC2

$$$$
SWF004841
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004841

>  <SMILES>
Cc1cncc(C(=O)N2CCC3(CC2)CN(Cc2cccnc2)C3=O)c1

$$$$
SWF004842
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9550   -3.3320   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4550   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1621   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6621   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1621    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1621    0.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6621    1.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 10 13  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004842

>  <SMILES>
CN(C)CC(=O)N1CCC2(CC1)C(=O)NC2c1ccccc1

$$$$
SWF004843
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6941   -0.1873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    2.5607   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5285    2.5607   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004843

>  <SMILES>
CN(C)S(=O)(=O)N1CCC2(CC1)CN(c1cccc(F)c1)C2=O

$$$$
SWF004844
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.2869   -6.7071   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004844

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccc(Cl)cc3)CC2)C1=O

$$$$
SWF004845
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  3  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7 10  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004845

>  <SMILES>
CN1CCN(CC#N)C(=O)C12CCN(Cc1cccnc1)CC2

$$$$
SWF004846
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.7961   -0.1248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004846

>  <SMILES>
CC(C)C(=O)N1CCC2(CC1)CN(Cc1cccnc1)C2=O

$$$$
SWF004847
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004847

>  <SMILES>
O=C1N(Cc2cccnc2)CC12CCN(Cc1ccsc1)CC2

$$$$
SWF004848
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.7869   -5.2459   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7869   -5.2459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4779   -4.2949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0959   -4.2949   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 20 21  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004848

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cscn3)CC2)C1=O

$$$$
SWF004849
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.9300    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5549   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 22 23  1  0  0  0  0
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 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004849

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccc(C)nc3)CC2)C1=O

$$$$
SWF004850
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.9300    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6888   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7229   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004850

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccc(C)cc3)CC2)C1=O

$$$$
SWF004851
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004851

>  <SMILES>
O=C(C1CCC1)N1CCC2(CC1)CN(Cc1cccnc1)C2=O

$$$$
SWF004852
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.1980    0.6248   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004852

>  <SMILES>
O=C1N(Cc2cccnc2)CC12CCN(Cc1cccnc1)CC2

$$$$
SWF004853
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF004853

>  <SMILES>
CC(C)(C)C(=O)N1CCC2(CC1)CN(c1cccnc1)C2=O

$$$$
SWF004854
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004854

>  <SMILES>
CCS(=O)(=O)N1CCC2(CC1)CN(Cc1cccnc1)C2=O

$$$$
SWF004855
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004855

>  <SMILES>
Cc1cc(C(=O)N2CC[C@]3(C2)C[C@@H](NS(C)(=O)=O)C3)[nH]n1

$$$$
SWF004856
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.3122    2.8231   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2258    2.4163   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004856

>  <SMILES>
CS(=O)(=O)N1CC[C@]2(C1)C[C@@H](NC(=O)c1ccncc1)C2

$$$$
SWF004857
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004857

>  <SMILES>
Cc1cccc(CN2C(=O)CC[C@@H]3[C@H]2CCN3Cc2cccnc2)n1

$$$$
SWF004858
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004858

>  <SMILES>
Cc1ccc(CN2CCC3(CC(N(C)c4ncccn4)CO3)C2)s1

$$$$
SWF004859
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004859

>  <SMILES>
O=S(=O)(c1cccs1)N1C[C@@H]2CN(CC3CCOCC3)C[C@@H]21

$$$$
SWF004860
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 27 29  2  0  0  0  0
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M  END
>  <HTSID>
SWF004860

>  <SMILES>
Cc1cccc(CN2CC(c3cn(C(C)C)cn3)C3(CCN(CC4CC4)C3=O)C2)c1

$$$$
SWF004861
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.0413   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004861

>  <SMILES>
CC(=O)N1CCC2(CC1)[C@@H]1CN(c3ncccn3)C[C@@H]1C(=O)N2C

$$$$
SWF004862
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004862

>  <SMILES>
CCN(Cc1ccccc1)C(=O)c1nc(-c2ccnn2-c2cccc(OC)c2)n2ccncc12

$$$$
SWF004863
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004863

>  <SMILES>
O=C(c1cscn1)N1CCOC2CCC1C2Oc1ncccc1F

$$$$
SWF004864
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004864

>  <SMILES>
COc1cc(N2CC3(C2)OCCC3COCc2ccncc2)ncn1

$$$$
SWF004865
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004865

>  <SMILES>
Cc1ccc(CN2CCC3(CCC3NS(=O)(=O)c3ccccc3)CC2)o1

$$$$
SWF004866
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004866

>  <SMILES>
CC(C)CCN1Cc2c(C(=O)Nc3cccnc3)ncn2-c2ccccc2S1(=O)=O

$$$$
SWF004867
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.1674   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004867

>  <SMILES>
c1cncc(O[C@H]2CN(Cc3ccoc3)[C@H]3CCCO[C@H]23)c1

$$$$
SWF004868
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF004868

>  <SMILES>
O=C(c1ccnnc1)N1C[C@@H]2CN(Cc3ccsc3)CCO[C@@H]2C1

$$$$
SWF004869
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.8549    4.2283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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M  END
>  <HTSID>
SWF004869

>  <SMILES>
c1cncc(OC[C@]23COC[C@H]2CN(Cc2ccco2)C3)c1

$$$$
SWF004870
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004870

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccno3)CC2)CN1Cc1cccnc1

$$$$
SWF004871
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  8 10  2  0  0  0  0
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  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004871

>  <SMILES>
O=C(c1ccco1)N1CCc2ncnc(-c3ccsc3)c2CC1

$$$$
SWF004872
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   14.9503   -3.0200   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004872

>  <SMILES>
CN(Cc1cccnc1)C1COC2(CCN(C(=O)c3cccc(Cl)c3)CC2)C1

$$$$
SWF004873
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 14 16  1  1  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004873

>  <SMILES>
O=C(NC[C@H]1OC[C@@H]2CCN(Cc3ccoc3)C[C@@H]21)c1ccsc1

$$$$
SWF004874
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  2  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 11 16  1  0  0  0  0
 12 13  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004874

>  <SMILES>
O=C(c1ccoc1)N1CCOCC1c1nccc(Nc2ccccn2)n1

$$$$
SWF004875
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004875

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)CC(OCc1cccnc1)CO2

$$$$
SWF004876
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.1665    1.4487   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004876

>  <SMILES>
CS(=O)(=O)N1C[C@H]2CCC[C@@]2(COCC2CCOCC2)C1

$$$$
SWF004877
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004877

>  <SMILES>
Fc1ccccc1OC[C@@H]1CO[C@@H]2CN(C3CCSCC3)C[C@H]12

$$$$
SWF004878
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF004878

>  <SMILES>
CC(C)CNC(=O)[C@H]1C[C@@H]2CN(Cc3cccnc3)C[C@H]1O2

$$$$
SWF004879
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF004879

>  <SMILES>
O=S(=O)(C1CC1)N1CC[C@]2(C[C@H](Oc3ncccc3F)CO2)C1

$$$$
SWF004880
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004880

>  <SMILES>
O=C([C@H]1C[C@@H]2CN(Cc3ccccn3)C[C@H]1O2)N1CCCC1

$$$$
SWF004881
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 12 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004881

>  <SMILES>
Cc1cc(C(=O)N2CC[C@]3(C[C@@H](OCc4ccncc4)CO3)C2)no1

$$$$
SWF004882
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    5.8893    2.8343   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004882

>  <SMILES>
CN1C[C@@]23CN(C(=O)Nc4ccc(F)cc4)C[C@@H](C[C@@H]2S1(=O)=O)O3

$$$$
SWF004883
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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M  END
>  <HTSID>
SWF004883

>  <SMILES>
O=C(c1cccnc1)N1CCCC2(CCN(c3ncccn3)C2)C1

$$$$
SWF004884
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.5772    4.5284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004884

>  <SMILES>
COCc1nnc2n1CCN(C(=O)c1ccc(C)cn1)C(C)C2

$$$$
SWF004885
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004885

>  <SMILES>
O=C(c1ccccn1)N1C[C@H](OCC2CCCC2)[C@H]2OCCC[C@H]21

$$$$
SWF004886
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004886

>  <SMILES>
CC(C)(CO)CNC(=O)c1cnc(-c2noc3cc(-c4ccc(F)cc4)ccc23)s1

$$$$
SWF004887
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004887

>  <SMILES>
O=C(Nc1cnccn1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccccn2)C1

$$$$
SWF004888
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004888

>  <SMILES>
O=C(N1CCCO1)[C@@]12CCO[C@@H]1CCN(Cc1ccccn1)C2

$$$$
SWF004889
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.6345    0.5759   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004889

>  <SMILES>
CCOC[C@@H]1CCC[C@@]12CN(Cc1ccc(OC)cc1)CCO2

$$$$
SWF004890
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004890

>  <SMILES>
c1ccc(CN2CC3(CCC(CNc4ncccn4)CO3)C2)nc1

$$$$
SWF004891
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004891

>  <SMILES>
Cc1nc(COC2CCOC3(C2)CN(Cc2cnn(C)c2)C3)cs1

$$$$
SWF004892
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004892

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)cs1

$$$$
SWF004893
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.2711   -0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674    0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004893

>  <SMILES>
c1ccc(OC[C@@]23CCO[C@@H]2CCN(Cc2ccncc2)C3)nc1

$$$$
SWF004894
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  1  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004894

>  <SMILES>
O=C(C[C@H]1[C@H]2CN(Cc3cccnc3)C[C@@H]12)Nc1cccnc1

$$$$
SWF004895
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004895

>  <SMILES>
Cc1ccc(C(=O)N2CCc3nc(N4CCOCC4)nc(C)c3CC2)cc1

$$$$
SWF004896
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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 26 29  1  0  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004896

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCN(C(=O)c4cccc(Cl)c4)CC3)[C@@H]1CN(C(C)=O)C2

$$$$
SWF004897
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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   -2.4752   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5685   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  6 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 18 20  1  0  0  0  0
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  9 12  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004897

>  <SMILES>
C[C@H]1C[C@H]2CN(C(=O)c3cc4ccccc4s3)CC[C@@H]2O1

$$$$
SWF004898
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004898

>  <SMILES>
Cc1cccc(CN2C[C@@H]3CN(C(=O)c4ccsc4)C[C@@H]3C2=O)c1

$$$$
SWF004899
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  2  0  0  0  0
 20 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004899

>  <SMILES>
COc1ccc(S(=O)(=O)N2CCc3ncnc(C4CC4)c3CC2)cc1

$$$$
SWF004900
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 10 13  1  0  0  0  0
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 22 26  1  0  0  0  0
 23 27  1  0  0  0  0
 25 28  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 24  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004900

>  <SMILES>
COc1cccc(CCN2C[C@H]3CCN(C(=O)C4CCC4)CC[C@H]3S2(=O)=O)c1

$$$$
SWF004901
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.3007   -1.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004901

>  <SMILES>
COCCNC(=O)c1cnc(-c2noc3cc(-c4ccc(F)cc4)ccc23)s1

$$$$
SWF004902
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5241   -4.4781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2620   -2.5477   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5984   -4.1303   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2565   -2.6522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4644   -3.6303   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9257   -1.9091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6166   -0.9580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9038   -2.1170   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2858   -0.2149   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5729   -1.3738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2639   -0.4228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9330    0.3204   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9112    0.1125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
  9 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 10 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004902

>  <SMILES>
COc1ccc(-c2nc(-c3noc4ccc(C(=O)N(C)C)cc34)co2)cc1

$$$$
SWF004903
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
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    2.8498    2.6685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3366    3.9124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1179    0.9935   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3031    3.4653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2718    5.0851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.9213   -2.7436   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6857   -7.7302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 12 19  1  0  0  0  0
 14 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 10 13  1  1  0  0  0
 15 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004903

>  <SMILES>
CCC(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(CC(C)C)[C@H]2CC1

$$$$
SWF004904
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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    0.3035   -8.8458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2367   -6.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004904

>  <SMILES>
CC(C)NC(=O)c1ccc2onc(-c3coc(-c4ccc(F)cc4)n3)c2c1

$$$$
SWF004905
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.4676   -4.5303   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004905

>  <SMILES>
Cc1ccc(-c2nc(-c3noc4ccc(C(=O)NC(C)C)cc34)cs2)cc1

$$$$
SWF004906
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
    7.8108   -0.2885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1417    0.4546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  1  0  0  0
 16 20  1  0  0  0  0
 18 21  1  6  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 26 30  1  0  0  0  0
  9 12  1  0  0  0  0
 14 17  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004906

>  <SMILES>
CC(=O)N1C[C@H]2C3(CCN(C(=O)Nc4ccccc4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF004907
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0827    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6759    0.9432   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0608   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.6814    1.0477   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2637    1.7522   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2582    1.6477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8570    2.6657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004907

>  <SMILES>
CN(C)C(=O)C1CCCC12CCN(C(=O)Cc1cccc(F)c1)C2

$$$$
SWF004908
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    8.7865   -2.7227   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2354   -3.1109   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3862   -1.3369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8658   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF004908

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)COc2ccccc2S(=O)(=O)N(C)C3)o1

$$$$
SWF004909
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7942    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4319   -0.2133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2221   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4393   -2.4427   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.9028   -1.0162   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3701   -0.7043   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004909

>  <SMILES>
Cc1ccc2c(c1)CCC21CCN(C(=O)Cc2ccc(F)cn2)CC1

$$$$
SWF004910
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    7.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    7.2709   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8660    8.1369   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    9.0029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8660    9.8690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8660    9.8690   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004910

>  <SMILES>
O=C(C1CCOCC1)N1CCC(c2nc3ccc(-c4ccncc4)cn3n2)CC1

$$$$
SWF004911
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9483    5.2433   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1349    7.0704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1294    6.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004911

>  <SMILES>
O=C(c1ccoc1)N1CCC2(CC1)CCN(c1ncccn1)C2

$$$$
SWF004912
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004912

>  <SMILES>
Cc1ccc(CC(=O)N2CCC3(CCCN(Cc4cccc(C)n4)C3=O)CC2)cc1

$$$$
SWF004913
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
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  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  7  2  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004913

>  <SMILES>
CC(C)N1C(=O)C2(CCN(C(=O)c3ccccc3)CC2)c2ccccc21

$$$$
SWF004914
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  2  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 22 25  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004914

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@@H](c2ccccc2)[C@@]2(CCN(c3ccsc3)C2=O)C1

$$$$
SWF004915
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  1  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  8  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004915

>  <SMILES>
CCOCCC1CCOC2(C1)CN(C(=O)Cc1cccc(OC)c1)C2

$$$$
SWF004916
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004916

>  <SMILES>
CN(c1ccccc1)c1ccc2ccc(C(=O)NCc3ccncc3)cn12

$$$$
SWF004917
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 14 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004917

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)Nc3ccccc3)CC2)Oc2ccccc21

$$$$
SWF004918
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.1104    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004918

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2cccc(C)c2)[C@H]1Cc1ccccc1

$$$$
SWF004919
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF004919

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CC(CC(=O)N1CCCC1)c1ccccc12

$$$$
SWF004920
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004920

>  <SMILES>
COc1cccc(CN2CCC3(CCN(C(=O)c4cccnc4)C3)C2=O)c1

$$$$
SWF004921
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  6  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 23 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004921

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccccc3)CC2)Oc2ccccc21)NC1CCC1

$$$$
SWF004922
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   13.9547   -1.3361   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.3446    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8528    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2262    1.2478   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2427    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9711   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7180    1.0910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.6161    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7509    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4793   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5827    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6483    2.6065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5790    4.3450   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1118    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  6  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004922

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CC(CC(=O)NCC1CC1)c1ccccc12

$$$$
SWF004923
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    9.3031   -0.8907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8964    0.0228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9018    0.1274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.4842    0.8318   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4951    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3141   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0774    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5006    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3195   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1819    2.7399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2684    2.3332   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7655    1.7377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0527    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0745    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  6  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004923

>  <SMILES>
CCN(CC)C(=O)CC1CC2(CCN(C(=O)CC3CC3)CC2)c2ccccc21

$$$$
SWF004924
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    8.7293    3.1740   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.0996    2.5639   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9428    4.0556   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8476    4.3875   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4577    5.7578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3559    4.2307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5373    2.4955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4742    5.4442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1107    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0843    6.8146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9960    3.0357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7988    0.5647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5694    2.5721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3722    0.1012   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2575    1.1049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004924

>  <SMILES>
COCCO[C@@H]1CCN(S(=O)(=O)c2ccccc2)[C@H]1Cc1ccccc1

$$$$
SWF004925
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5844   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6451   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8344   -4.9979   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314   -7.8107   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 11 14  1  0  0  0  0
 12 13  2  0  0  0  0
 16 18  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004925

>  <SMILES>
O=C1N(c2cccc(F)c2)CC12CCN(S(=O)(=O)c1cccs1)CC2

$$$$
SWF004926
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.6178    8.7877   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.8678    7.4887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3678    7.4887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6178    6.1896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6178    6.1896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8678    4.8906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3678    4.8906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6178    3.5915   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1178    3.5915   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3678    2.2925   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3678    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6178    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1178    0.9935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7850    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004926

>  <SMILES>
Cc1nc(-c2ccc(F)cc2)nc2c1CCN(C(=O)NC1CCCC1)CC2

$$$$
SWF004927
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    9.8707   -9.4052   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.3789   -9.2484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0404   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  9 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  6  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
  7 10  1  0  0  0  0
 14 15  1  0  0  0  0
 18 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004927

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)c3ccccc3F)CC2)c2ccccc21

$$$$
SWF004928
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -6.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  6  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 20  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004928

>  <SMILES>
Cc1ccc(C(=O)N2CCC3(CC2)CC(CC(=O)N(C)C)c2ccccc2O3)cc1

$$$$
SWF004929
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7850    1.4958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8846    2.5161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3679    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.3879   -1.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1264    0.7652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5027   -2.1693   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2411   -0.2385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9292   -1.7058   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0440   -2.7095   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 11 12  2  0  0  0  0
 14 15  2  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004929

>  <SMILES>
CCS(=O)(=O)N1CCc2[nH]nc(-c3ccc(F)cc3)c2CC1

$$$$
SWF004930
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004930

>  <SMILES>
Cc1csc(C(=O)N2CCc3ncnc(-c4cncnc4)c3C2)c1

$$$$
SWF004931
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4955    5.4049   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3615    3.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295    2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3615    2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 10  1  6  0  0  0
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 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004931

>  <SMILES>
Cc1cccc(NC(=O)N2CCC3(CC(=O)N(c4cccc(F)c4)C3)C2)c1

$$$$
SWF004932
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004932

>  <SMILES>
CCc1ccc(C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)cc1

$$$$
SWF004933
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004933

>  <SMILES>
COc1ccc(C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)cc1F

$$$$
SWF004934
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004934

>  <SMILES>
Cc1ccccc1CC(=O)NCC1OCCc2cn(Cc3ccccc3)nc21

$$$$
SWF004935
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004935

>  <SMILES>
c1ccc(-c2ccc3nc(C4CCN(Cc5cccs5)CC4)nn3c2)cc1

$$$$
SWF004936
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2788   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7788   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 23  2  0  0  0  0
 11 13  1  6  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004936

>  <SMILES>
COCC(=O)NC[C@@H]1CO[C@@H]2CN(Cc3ccccc3C)C[C@H]12

$$$$
SWF004937
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4252   -0.8135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5235   -3.7385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  4  8  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004937

>  <SMILES>
O=C1NC[C@H](COc2ccccn2)[C@]12CCN(Cc1ccco1)C2

$$$$
SWF004938
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.2160   -2.7205   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9427   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1337   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
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  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
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 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 11  1  0  0  0  0
 12 14  2  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004938

>  <SMILES>
Cn1cccc1C(=O)N1C[C@H](Oc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF004939
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2226    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5608   -0.6285   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2007    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8698    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8480    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2547    1.4440   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5911   -0.1387   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2492    1.3395   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4572    0.3613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3707   -0.0454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  8  7  1  1  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF004939

>  <SMILES>
Cc1noc([C@@H]2CC[C@@H]3[C@@H](CCN3Cc3nccs3)O2)n1

$$$$
SWF004940
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.6370    1.6183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    3.3125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6891    4.1215   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    3.6215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2769    4.9305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6891    4.1215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2280    4.6215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 13  1  0  0  0  0
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  9 15  1  6  0  0  0
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 10 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 12 14  2  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004940

>  <SMILES>
Cn1cccc1C(=O)N1CCO[C@H]2[C@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF004941
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.6316    1.7228   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0383    0.8092   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4291    0.6401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2952    0.1401   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004941

>  <SMILES>
c1ccc(CO[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2cccs2)nc1

$$$$
SWF004942
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  1  0  0  0
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 18 19  1  0  0  0  0
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 21 23  1  0  0  0  0
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 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF004942

>  <SMILES>
Fc1cccnc1O[C@@H]1CC[C@H]2[C@H]1OCCN2Cc1ccco1

$$$$
SWF004943
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
  6  9  1  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF004943

>  <SMILES>
c1coc(CN2CCO[C@H]3[C@H](OCC4CCOCC4)CC[C@@H]32)c1

$$$$
SWF004944
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 18 20  1  0  0  0  0
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 14 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF004944

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(Cc3ccoc3)CC2)c2ccccc21

$$$$
SWF004945
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF004945

>  <SMILES>
O=C(c1ccco1)N1CCO[C@H]2[C@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF004946
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF004946

>  <SMILES>
Cn1cc(CN2CCC3(CCCN(c4ncccn4)C3)C2)cn1

$$$$
SWF004947
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004947

>  <SMILES>
O=C1N(Cc2cccnc2)CCC12CCCN(Cc1ccoc1)C2

$$$$
SWF004948
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004948

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)CCN(c1ccccc1)C2=O

$$$$
SWF004949
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF004949

>  <SMILES>
c1ccc(OC2COC3(CCN(Cc4cccs4)CC3)C2)cc1

$$$$
SWF004950
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004950

>  <SMILES>
COCCOc1nc(-c2ccccc2)nc2c1CCN(C(=O)Cc1ccccc1)CC2

$$$$
SWF004951
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004951

>  <SMILES>
COCCN1CCC2(COCCN(Cc3ccncc3)C2)C1

$$$$
SWF004952
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  2  0  0  0  0
 10 13  1  0  0  0  0
 17 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004952

>  <SMILES>
Cc1cccc(C(=O)NCC2OCCc3cn(Cc4ccccc4)nc32)c1

$$$$
SWF004953
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.5527   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 22  1  0  0  0  0
  6  8  1  0  0  0  0
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 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF004953

>  <SMILES>
Cc1ccc(CN2C[C@H](OCCN(C)C)[C@H]3OCCC[C@H]32)o1

$$$$
SWF004954
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004954

>  <SMILES>
CC(C)NC(=O)c1ccc2onc(-c3coc(-c4ccccc4)n3)c2c1

$$$$
SWF004955
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 16  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF004955

>  <SMILES>
CCC1COC2(CCN(C(=O)c3ccc(OC)cc3C)C2)C1

$$$$
SWF004956
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8660    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004956

>  <SMILES>
CN(C)C(=O)N1CCC2OCCCC2(COc2ccccn2)C1

$$$$
SWF004957
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5994   -2.6010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004957

>  <SMILES>
Cc1ccc(OC[C@H]2CO[C@@H]3CN(C(=O)c4ccc(O)nn4)C[C@H]23)cn1

$$$$
SWF004958
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004958

>  <SMILES>
CCCNC(=O)c1ncn2c1CCC(C(=O)NCC1CC1)C2

$$$$
SWF004959
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004959

>  <SMILES>
Cn1cc(CN2C[C@@H]3CN(C(=O)c4cnccn4)C[C@@H]3C2)cn1

$$$$
SWF004960
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 11 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004960

>  <SMILES>
CCS(=O)(=O)N1CCC2(CCN(c3ncccn3)C2)CC1

$$$$
SWF004961
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.4957    0.6423   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0762    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7597   -0.1652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9165   -1.6570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004961

>  <SMILES>
COCCN1CCC2(COCCN(Cc3cccnc3)C2)C1

$$$$
SWF004962
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004962

>  <SMILES>
c1cncc(CN2CCC3(CC2)COCCN3CC2CC2)c1

$$$$
SWF004963
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.8024    2.8563   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6841    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4125    4.2267   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1759    1.7996   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.9043    4.3835   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7860    3.1699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5822    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004963

>  <SMILES>
c1ccc(CN2CCC3(CCCN(c4ncccn4)C3)C2)nc1

$$$$
SWF004964
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7983   -2.0160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2105   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0295   -4.5476   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6118   -3.8431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004964

>  <SMILES>
O=C(c1cnccn1)N1CCCC2(CC(Oc3cccnc3)CO2)C1

$$$$
SWF004965
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.0026   -4.5816   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4944   -4.4248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004965

>  <SMILES>
c1ccc(CN2CCC3(CC2)CCN(Cc2cccs2)C3)nc1

$$$$
SWF004966
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9402   -1.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2566   -2.4421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF004966

>  <SMILES>
Cc1cccc(CN2C(=O)CC[C@@H]3[C@H]2CCN3C(=O)c2ccco2)n1

$$$$
SWF004967
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004967

>  <SMILES>
O=C(c1cccs1)N1C[C@@H]2CN(c3ncccn3)C[C@@H]2C1

$$$$
SWF004968
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004968

>  <SMILES>
O=C(NCc1cccnc1)C1CCCC12CCN(Cc1ccncc1)C2

$$$$
SWF004969
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF004969

>  <SMILES>
Cn1cncc1CN1CC[C@]2(CCC[C@@H]2C(=O)N2CC(F)(F)C2)C1

$$$$
SWF004970
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004970

>  <SMILES>
Cc1noc(C)c1CN1C[C@@H]2CN(C(=O)c3cnccn3)C[C@@H]2C1

$$$$
SWF004971
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004971

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(C(=O)C3CC(O)C3)C[C@H]2O1)N1CCOCC1

$$$$
SWF004972
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004972

>  <SMILES>
COc1cc(N2CC[C@@H]3[C@@H]2CCN3Cc2cccnc2)ncn1

$$$$
SWF004973
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004973

>  <SMILES>
CN(C)S(=O)(=O)N1CCC2(CC(C(=O)Nc3cccnc3)=NO2)C1

$$$$
SWF004974
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  2  0  0  0  0
 12 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  6  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004974

>  <SMILES>
O=C(N[C@@H]1CN(Cc2cccnc2)[C@@H]2CCCO[C@@H]21)c1cnccn1

$$$$
SWF004975
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004975

>  <SMILES>
O=S(=O)(C1CC1)N1CC[C@@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF004976
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004976

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)o1

$$$$
SWF004977
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004977

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CN(Cc3ccccn3)C[C@@H]2N1C(C)=O

$$$$
SWF004978
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF004978

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2OC(COCC(=O)N3CCCC3)CC[C@@H]21

$$$$
SWF004979
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF004979

>  <SMILES>
Cc1ccc(C(=O)N2CC3(C2)OCCC3CCOCC2CCOCC2)cc1

$$$$
SWF004980
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 14  1  1  0  0  0
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 18 20  2  0  0  0  0
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 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 16 17  1  0  0  0  0
 20 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004980

>  <SMILES>
COc1ccc(CC(=O)N2CCC3(COc4ccccc43)C2)cc1F

$$$$
SWF004981
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   12.2294   -3.3107   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9304   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6314   -1.8107   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1313   -1.8107   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3813   -0.5116   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7 11  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004981

>  <SMILES>
O=S(=O)(c1ccccc1Cl)N1CC2(CC(OCC3CC3)CCO2)C1

$$$$
SWF004982
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF004982

>  <SMILES>
Cc1noc(C)c1C(=O)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF004983
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.6032   -4.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004983

>  <SMILES>
COCC(=O)N1CCC2(CCN(Cc3nccs3)CC2)CC1

$$$$
SWF004984
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.4676   -4.5303   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 23 24  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF004984

>  <SMILES>
CC(C)NC(=O)c1ccc2onc(-c3csc(-c4ccccc4)n3)c2c1

$$$$
SWF004985
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  1  1  0  0  0
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 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 11 15  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF004985

>  <SMILES>
Cn1cnc2c1C(C(=O)O)CN(S(=O)(=O)c1ccccc1)C2

$$$$
SWF004986
Actelion Java MolfileCreator 1.0

 27 29  0  0  1  0  0  0  0  0999 V2000
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 21 24  1  0  0  0  0
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 10 13  1  1  0  0  0
 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF004986

>  <SMILES>
CCC(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(CCC(C)C)[C@H]2CC1

$$$$
SWF004987
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  6 10  1  0  0  0  0
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 22 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 10 13  1  1  0  0  0
 15 20  1  0  0  0  0
 21 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF004987

>  <SMILES>
CC(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(Cc3ccccc3)[C@H]2CC1

$$$$
SWF004988
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF004988

>  <SMILES>
CC(C)CCN1C[C@H]2CCN(C(=O)Nc3ccccc3)CC[C@H]2S1(=O)=O

$$$$
SWF004989
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6160    1.3398   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.8591    0.9269   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 11  2  0  0  0  0
 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF004989

>  <SMILES>
Cn1cccc1C(=O)NCc1cnc2n1CCN(CC1CC1)CC2

$$$$
SWF004990
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  6  0  0  0
 24 25  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004990

>  <SMILES>
COC1CCC2(CCN(C(=O)CC3(O)CCC3)CC2)c2ccccc21

$$$$
SWF004991
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    2.4433   -5.0284   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13  9  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 18  1  0  0  0  0
 17 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF004991

>  <SMILES>
O=C(Nc1ccccc1)N1CC[C@@H]2CCN(C(=O)NCc3ccccc3)[C@@H]2CC1

$$$$
SWF004992
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.0124    1.0516   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF004992

>  <SMILES>
COc1ccc(CN2CCC3(CCCN(C(=O)C4(F)CCC4)C3)C2=O)cc1

$$$$
SWF004993
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   12.0455   -2.2842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF004993

>  <SMILES>
O=C1NC2(CCN(S(=O)(=O)C3CC3)CC2)CC1c1cccnc1

$$$$
SWF004994
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  6  1  0  0  0  0
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 11 14  1  0  0  0  0
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 15 19  2  0  0  0  0
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  9 11  2  0  0  0  0
 16 19  1  0  0  0  0
 21 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF004994

>  <SMILES>
Cc1cnc(CNC(=O)c2cc(-c3cnc(N4CCCC4)nc3)cn2C)cn1

$$$$
SWF004995
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  5  9  2  0  0  0  0
  6 10  2  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 16 19  1  1  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  7  1  0  0  0  0
  9 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF004995

>  <SMILES>
COCCC1CN(C(=O)c2cc3ccccc3s2)Cc2ccnn21

$$$$
SWF004996
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 19 15  1  6  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF004996

>  <SMILES>
CN1CCN(C(=O)c2ccc3nnc(C4CN(c5ncccn5)CCN4C)n3c2)CC1

$$$$
SWF004997
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF004997

>  <SMILES>
Cc1ccc(N2CC[C@@H]3[C@@H]2CCN3C(=O)c2ccccn2)nn1

$$$$
SWF004998
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF004998

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CN(Cc2cccnc2)CCO3)n1

$$$$
SWF004999
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3551    3.0021   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4416    3.4089   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2506    2.0076   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2725    1.7997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8712    0.7816   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF004999

>  <SMILES>
COCCN1CC2(CCCCN2C(=O)c2csnn2)CC1=O

$$$$
SWF005000
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0461    2.1333   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1696    0.1874   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9026    0.8675   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6939    2.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5600    1.8647   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6939    3.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005000

>  <SMILES>
CNC(=O)c1nc2c(s1)CCN(C(=O)c1ccc(OC)cc1)CC2

$$$$
SWF005001
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6  8  1  0  0  0  0
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  8 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
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 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005001

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2OCCN(Cc3ccncc3)[C@H]2C1

$$$$
SWF005002
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7431   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3364   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8364   -3.9487   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005002

>  <SMILES>
CO[C@@H]1CCN(Cc2ccoc2)[C@@H]2CN(Cc3ccncc3)C[C@@H]21

$$$$
SWF005003
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  2  0  0  0  0
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  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005003

>  <SMILES>
C[C@@H]1CN(C(=O)c2cccs2)C[C@]12CCN(c1cccnc1)C2=O

$$$$
SWF005004
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    7.3493   -3.7386   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9426   -2.8250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9480   -2.7205   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5413   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603   -3.5295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1236   -1.1025   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7114   -0.2935   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1291   -0.9979   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 27 29  2  0  0  0  0
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  9 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005004

>  <SMILES>
Cc1ccc(NC(=O)N2CCCC3(CC(C(=O)NCc4ccncc4)=NO3)C2)cc1

$$$$
SWF005005
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 17 20  1  0  0  0  0
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 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005005

>  <SMILES>
O=C1N(Cc2ccncc2)CCOC12CN(Cc1cccs1)CC2c1cccnc1

$$$$
SWF005006
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  1  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005006

>  <SMILES>
Cc1nc(CN2CCC3(CCN(C(=O)C4CCOC4)CC3)C2)cs1

$$$$
SWF005007
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
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 12 10  1  6  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005007

>  <SMILES>
CC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(C(=O)Cc3ccsc3)C[C@H]12

$$$$
SWF005008
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005008

>  <SMILES>
COCC(=O)N1CCC2(CC1)CC(COC)N(Cc1ccccn1)C2

$$$$
SWF005009
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.7634   -4.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005009

>  <SMILES>
Cc1ccccc1N1CC2(CCN(C3CCOCC3)C2)CC1=O

$$$$
SWF005010
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  5  8  1  0  0  0  0
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 10  7  1  1  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005010

>  <SMILES>
O=C(NCCN1CCCC1)C1=NOC2(CCN(Cc3ccoc3)C2)C1

$$$$
SWF005011
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005011

>  <SMILES>
Cn1ccc(C(=O)N2CC3(CC(Oc4ncccn4)CCO3)C2)n1

$$$$
SWF005012
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
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 26 27  1  0  0  0  0
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 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005012

>  <SMILES>
Cn1cc(CN2CCCC3(CCN(C(=O)CCc4cncnc4)C3)C2)cn1

$$$$
SWF005013
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
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 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005013

>  <SMILES>
COCC1CN(C(=O)c2ccncc2)Cc2ncn(CC3CC3)c21

$$$$
SWF005014
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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   -7.4595    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7310   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2310   -1.9978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005014

>  <SMILES>
O=C(C1CCOC1)N1CCC2(CCN(Cc3nccs3)C2)CC1

$$$$
SWF005015
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005015

>  <SMILES>
Cc1cnc(C(=O)N2C[C@@H]3C[C@@H](c4ccncn4)O[C@@H]3C2)cn1

$$$$
SWF005016
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9544   -4.9927   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005016

>  <SMILES>
O=C([C@H]1CCCO1)N1CCC2(CC(Oc3cccnc3)CO2)C1

$$$$
SWF005017
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7521    0.8318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005017

>  <SMILES>
CN(Cc1cccnc1)C1COC2(CCN(C(=O)C3CCC3)CC2)C1

$$$$
SWF005018
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  6  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005018

>  <SMILES>
O=C(CCF)N1CCC2(CCc3nc(-c4ccccc4)cc(=O)n3CC2)C1

$$$$
SWF005019
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    4.6937    2.6329   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <HTSID>
SWF005019

>  <SMILES>
CN(C)C(=O)COC1CN(S(C)(=O)=O)Cc2cccn2C1

$$$$
SWF005020
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2961    0.2588   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005020

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(C(=O)c2cc[nH]n2)C3)n1

$$$$
SWF005021
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3581    1.2788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6859    3.3479   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 14  2  0  0  0  0
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 13 16  2  0  0  0  0
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 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005021

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H](O)[C@@H]1Cc1ccccc1

$$$$
SWF005022
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005022

>  <SMILES>
CO[C@H]1CO[C@]2(CCCN(C(=O)CCc3ccccc3F)C2)C1

$$$$
SWF005023
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005023

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)c4cc[nH]c4)C[C@H]32)cs1

$$$$
SWF005024
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7242   -3.4547   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  2  0  0  0  0
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 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
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 15 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005024

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(C1)CN(Cc1ccccc1)c1cccnc12

$$$$
SWF005025
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6654   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3040   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5314   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005025

>  <SMILES>
CNC(=O)[C@@H]1C[C@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@H]2N1C

$$$$
SWF005026
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4526   -5.1476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4025    1.0477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2661   -6.9746   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  1  0  0  0
  7 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  1  0  0  0  0
 17 23  1  0  0  0  0
 18 24  1  0  0  0  0
 19 25  2  0  0  0  0
 19 26  1  0  0  0  0
 20 27  2  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 27  1  0  0  0  0
 22 24  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005026

>  <SMILES>
Cn1nccc1[C@@H]1CN(C(=O)C2CC2)C[C@]12CCCN(Cc1cccnc1)C2=O

$$$$
SWF005027
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.8891    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5800    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2492   -0.2127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -1.1908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2437   -0.1081   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9073   -1.6908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2149   -3.5485   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1322   -4.7510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1104   -4.5431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005027

>  <SMILES>
CC(=O)N1C(CN2CCCC2)C[C@@H]2CN(C(=O)c3ccoc3)CC[C@@H]21

$$$$
SWF005028
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   11.2792   -1.6106   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8119   -1.2988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4360   -3.1024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0619   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0656   -3.7125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783   -0.1727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005028

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CC1)CCN(c1ccsc1)C2=O

$$$$
SWF005029
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6649   -5.9814   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005029

>  <SMILES>
O=C(NC1CCc2onc(CN3CCCC3)c2C1)c1ccnnc1

$$$$
SWF005030
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6980   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9909   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -2.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005030

>  <SMILES>
CN(C)C1CC2(CCN(C(=O)c3cccc(=O)n3C)CC2)C1

$$$$
SWF005031
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4020    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6420    3.7898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3851    4.4589   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6909    4.0988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5319    5.3859   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7888    4.7168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1623    5.0258   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3702    6.0040   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3212    6.3130   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005031

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3ccc(COC)cc3)C[C@H]2C)C1=O

$$$$
SWF005032
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.0145    2.4885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9280    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005032

>  <SMILES>
O=C(NC1CCCCC1)C1CC2(CO1)CN(Cc1nccs1)CCO2

$$$$
SWF005033
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2513   -1.8799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.8678   -4.2784   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6599   -3.3003   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005033

>  <SMILES>
CC(C)CNC(=O)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF005034
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.3202   -2.5537   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0702   -3.8527   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8202   -5.1517   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0702   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5702   -6.4508   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -5.1517   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -3.8527   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005034

>  <SMILES>
O=C(NCC1CC1)[C@H]1C[C@@H]2[C@@H](C1)OCCN2Cc1ccc(F)c(F)c1

$$$$
SWF005035
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.0243    3.8786   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0461    4.0865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1288    2.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5461    3.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2152    2.4774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    3.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9757    0.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4405   -1.0540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6484   -2.0322   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005035

>  <SMILES>
CCOCC(=O)N1CCC2(CC1)CN(Cc1ccsc1)CC2COC

$$$$
SWF005036
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   12.9401    4.0031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.5699    4.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7833    5.4948   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.4041    5.5571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6259    3.4474   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4601    4.3914   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9684    4.2346   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0867    5.4482   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3583    2.8643   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8910    2.5524   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1083    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1046    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3460   -0.3882   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2341   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005036

>  <SMILES>
Cn1cc(C(=O)N[C@H]2C[C@]3(CCN(C(=O)C4CC(F)(F)C4)C3)C2)cn1

$$$$
SWF005037
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    7.5392   -2.0193   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5611   -1.8114   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6437   -3.0139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0611   -2.6775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7302   -3.4206   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0665   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5665   -3.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5884   -3.4401   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 13 10  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
  9 11  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005037

>  <SMILES>
O=C(c1ccco1)N1C[C@H]2Cn3c(-c4ccsc4)cnc3[C@H]2C1

$$$$
SWF005038
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2215    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6337    2.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.0404    3.3385   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005038

>  <SMILES>
Cc1nc(C(=O)N2CCCC3(CCN(c4cccnc4)C3=O)C2)cs1

$$$$
SWF005039
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3283   -1.7783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -3.7090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2136   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2774   -6.7201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3921   -7.7238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1492   -7.1836   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0803   -9.1910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005039

>  <SMILES>
O=C1CCC2(CCN(CC3CCCCC3)CC2)N1Cc1cccnc1

$$$$
SWF005040
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1312    4.5456   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1257    4.6502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5324    5.5637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7080    3.9457   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3068    2.9276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3122    2.8231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005040

>  <SMILES>
O=C(N[C@H]1C[C@]2(CCN(C(=O)Cn3ccccc3=O)C2)C1)C1CC1

$$$$
SWF005041
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4460   -2.1765   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0594   -0.7988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0022    2.0349   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9184   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005041

>  <SMILES>
CC(C)CN1CC2(CCN(C(=O)C3CC(O)C3)CC2)C2(CCNC2=O)C1

$$$$
SWF005042
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2322   -2.5597   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9840   -1.2576   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7614   -2.2471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9779   -0.1402   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6043   -0.7518   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3021   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3021    1.5036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7518   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3021    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2554   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005042

>  <SMILES>
CCN1CCC2(CN(C(C)=O)CC23CCN(C(=O)c2csnn2)CC3)C1=O

$$$$
SWF005043
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   13.5010   -4.0466   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   13.2775   -2.5634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.6737   -3.1114   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7869   -2.3955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5676    1.6642   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5363    0.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005043

>  <SMILES>
C=CCN1CCOC2CN(C(=O)C3CC(F)(F)C3)CCC2C1

$$$$
SWF005044
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005044

>  <SMILES>
O=C(N1CCCC2(COCCN(c3ccccn3)C2)C1)C1(F)CC1

$$$$
SWF005045
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005045

>  <SMILES>
O=C(c1cccc(Cl)n1)N1CCCC2(CC(Nc3cnccn3)CO2)C1

$$$$
SWF005046
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005046

>  <SMILES>
COCc1ccc(C(=O)N2CC[C@H]3CO[C@H](CNS(C)(=O)=O)[C@H]3C2)cc1

$$$$
SWF005047
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005047

>  <SMILES>
CCN1C[C@H](COC)[C@]2(CCN(C(=O)Cc3ccccc3)C2)C1

$$$$
SWF005048
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005048

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(C(=O)c2cccnc2)C3)n1

$$$$
SWF005049
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005049

>  <SMILES>
Cn1cnc2c1C(COCc1ccccc1)N(Cc1ccccn1)CC2

$$$$
SWF005050
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
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 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005050

>  <SMILES>
COc1cccc(NC(=O)N2CCN(S(C)(=O)=O)CC3(CC(=O)N(C)C3)C2)c1

$$$$
SWF005051
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411    3.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    4.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005051

>  <SMILES>
COCC1c2c(cnn2CC2CCOCC2)CCN1C(=O)c1ccoc1

$$$$
SWF005052
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005052

>  <SMILES>
Cc1cc(C(=O)N2CC3(C2)OCCC3CCNS(C)(=O)=O)no1

$$$$
SWF005053
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  8  1  1  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
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 23 26  2  0  0  0  0
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 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005053

>  <SMILES>
Cc1ccccc1CN1CC2(C1)OCCC2CCNC(=O)c1ccncc1

$$$$
SWF005054
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  6  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005054

>  <SMILES>
CCS(=O)(=O)N1Cc2ncn(CC3CC3)c2C(COC)C1

$$$$
SWF005055
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.3461   -3.7413   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6770   -2.9981   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005055

>  <SMILES>
C[C@@H]1CN(C(=O)c2ccccn2)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF005056
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
 16 17  2  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005056

>  <SMILES>
O=C(COC1CCCC1)N1Cc2ccnn2C(CN2CCCC2)C1

$$$$
SWF005057
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005057

>  <SMILES>
CN(C)C1CCN(C(=O)C2=NOC3(CCN(Cc4cccc(F)c4)C3)C2)CC1

$$$$
SWF005058
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 18  1  1  0  0  0
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 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005058

>  <SMILES>
Cn1ccc(C(=O)N2CC3(CC(OCC4CCOCC4)CCO3)C2)n1

$$$$
SWF005059
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <HTSID>
SWF005059

>  <SMILES>
CC(C)N(C)Cc1cn2c(n1)CN(Cc1cccs1)CC2

$$$$
SWF005060
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6192   -3.3036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  2  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005060

>  <SMILES>
CN(Cc1cn2c(n1)CN(S(=O)(=O)C1CC1)CC2)Cc1ccco1

$$$$
SWF005061
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.1753    0.2319   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005061

>  <SMILES>
c1ccc(CO[C@H]2C[C@@H]3CN(Cc4cccs4)CCN3C2)nc1

$$$$
SWF005062
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 23 25  2  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005062

>  <SMILES>
CNC(=O)NCC1CCC2(CCN(C(=O)c3ccccn3)CC2)CO1

$$$$
SWF005063
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.8585    3.3792   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005063

>  <SMILES>
COCCN1CCOC2CCN(C(=O)c3c[nH]cn3)CCC21

$$$$
SWF005064
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005064

>  <SMILES>
COCC(=O)N1CCC(c2nc3ccc(-c4ccccc4)cn3n2)CC1

$$$$
SWF005065
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005065

>  <SMILES>
CNC(=O)c1cnc2n1CCN(Cc1ccc(OC)cc1)C2

$$$$
SWF005066
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005066

>  <SMILES>
O=C(NCCO)c1cc(-c2cnc(N3CCOCC3)nc2)cn1CC1CC1

$$$$
SWF005067
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005067

>  <SMILES>
Cc1cnc(N2CCc3ncnc(N4CCN(C)CC4)c3CC2)nc1

$$$$
SWF005068
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
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  7  8  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005068

>  <SMILES>
COc1ccc2c(c1)C1(CCN(Cc3cccnc3)CC1)N(C)CC2

$$$$
SWF005069
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005069

>  <SMILES>
CCCNC(=O)c1cc(-c2cnc(N(C)C)nc2)cn1CC1CC1

$$$$
SWF005070
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.4932   -3.8083   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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 11  7  1  6  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005070

>  <SMILES>
CNC(=O)C[C@@H]1C[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@H]2O1

$$$$
SWF005071
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
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 11 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF005071

>  <SMILES>
O=C(CO)NC1CC2(CCN(Cc3ccco3)CC2)Oc2ccccc21

$$$$
SWF005072
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.7543    2.2577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    1.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7543    0.6397   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7054    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0733   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1277   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 16 18  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005072

>  <SMILES>
O=C(NCc1cccnc1)[C@]12COC[C@H]1CN(Cc1nccs1)C2

$$$$
SWF005073
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005073

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(Cc3ccccc3)CC2)C1

$$$$
SWF005074
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -2.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321   -2.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6888   -4.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -4.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005074

>  <SMILES>
Cc1cccnc1CN1CCC2(CC1)CC(NC(=O)C1CC1)C2

$$$$
SWF005075
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    3.8046    1.1939   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1104    1.5540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2149    2.5485   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1322    1.3461   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005075

>  <SMILES>
O=C(c1cc(-c2cnc(-c3ccccc3)nc2)cn1CC1CC1)N1CCCC1

$$$$
SWF005076
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
   10.5901    2.5008   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.5864    3.6155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0500    5.0421   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  2  1  1  0  0  0
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  4  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005076

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCN(C(=O)Cc4ccccc4)CC3)[C@@H]1CN(C)C2

$$$$
SWF005077
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    2.6425    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    4.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005077

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCN(C(=O)c4cccnc4)CC3)[C@@H]1CN(S(C)(=O)=O)C2

$$$$
SWF005078
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005078

>  <SMILES>
CN(Cc1ccccc1)C1COC2(CCN(Cc3cccs3)CC2)C1

$$$$
SWF005079
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF005079

>  <SMILES>
CN1CC[C@]2(CN(C(=O)c3ccno3)C[C@H]2c2ccccc2)C1=O

$$$$
SWF005080
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
 10 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF005080

>  <SMILES>
Cc1ccc(CN2CC[C@H]3[C@H]2CCN3CC(=O)N(C)C)cc1C

$$$$
SWF005081
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005081

>  <SMILES>
CS(=O)(=O)NCC1CN(CC2CCCC2)Cc2cncn21

$$$$
SWF005082
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
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  9 11  1  0  0  0  0
 18 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005082

>  <SMILES>
COc1cccc(NC2COC3(CCN(CC(C)C)CC3)C2)c1

$$$$
SWF005083
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8367    2.4790   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 15 19  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005083

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)Cc1ccccc1)C2

$$$$
SWF005084
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
 10 11  1  0  0  0  0
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 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005084

>  <SMILES>
Cc1cccnc1CN1CCC2(CC1)CC(Nc1ncccn1)C2

$$$$
SWF005085
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   14.5211    4.4017   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
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 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF005085

>  <SMILES>
COc1ccc(CN2CCn3cc(CN(C)C)nc3C2)cc1

$$$$
SWF005086
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005086

>  <SMILES>
CCS(=O)(=O)N1CCC(F)(F)C2(CCN(c3ccccn3)C2)C1

$$$$
SWF005087
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10  7  1  1  0  0  0
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M  END
>  <HTSID>
SWF005087

>  <SMILES>
N#Cc1cccc(CN2CCC3(CC(C(=O)NCc4ccco4)=NO3)C2)c1

$$$$
SWF005088
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005088

>  <SMILES>
Cn1cc(C(=O)NC2CC3(CCN(Cc4ccccn4)CC3)C2)cn1

$$$$
SWF005089
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005089

>  <SMILES>
Cc1cccc(CN2CCC3(C2)Cn2c(-c4cccc(F)c4)cnc2CO3)c1

$$$$
SWF005090
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005090

>  <SMILES>
O=C(C1CCC1)N1CCC2(CC1)CCn1c(-c3ccccc3)cnc12

$$$$
SWF005091
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005091

>  <SMILES>
Cc1cccc(N2CCC3(CC2)CC(N(C)Cc2ccncc2)C3)n1

$$$$
SWF005092
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
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 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005092

>  <SMILES>
Cn1nc(CN2CCCCC2)c2c1CN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)C2

$$$$
SWF005093
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.2321    4.0388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321    4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411    3.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230    3.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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 13 15  1  0  0  0  0
 17 19  2  0  0  0  0
M  END
>  <HTSID>
SWF005093

>  <SMILES>
CCn1ncc2c1C(COC)N(C(=O)c1cscn1)CC2

$$$$
SWF005094
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005094

>  <SMILES>
CS(=O)(=O)NC1CC2(CCN(Cc3ccncc3)CC2)C1

$$$$
SWF005095
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005095

>  <SMILES>
CN1C[C@]2(COCC1=O)CN(C(=O)c1csnn1)C[C@H]2N(C)C

$$$$
SWF005096
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.3461   -3.7413   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  7  1  6  0  0  0
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 10 13  1  0  0  0  0
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 16 17  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 10 11  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005096

>  <SMILES>
C[C@@H]1CN(C(=O)c2cnccn2)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF005097
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005097

>  <SMILES>
CN1CC[C@]2(CN(C(=O)c3ccsc3)C[C@H]2c2ccccc2)C1=O

$$$$
SWF005098
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4179   -6.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6386   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
  7 12  1  0  0  0  0
 15 19  1  0  0  0  0
 16 17  1  0  0  0  0
 25 27  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <HTSID>
SWF005098

>  <SMILES>
Cn1cc(N2CCN(Cc3ccccc3)C3(CCN(Cc4nccn4C)CC3)C2=O)cn1

$$$$
SWF005099
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0686   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5173   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5173   -4.1970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3834   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2494   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3834   -1.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1154   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2494   -1.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1154   -1.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9814   -1.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005099

>  <SMILES>
COCCN1C(=O)C[C@@H]2[C@H]1CCN2C(=O)c1ccc(C)cc1

$$$$
SWF005100
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    8.2196    3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    3.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2196    2.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2685    2.1255   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005100

>  <SMILES>
CC1c2nc(C(=O)NC3CC3)cn2CCN1Cc1ccsc1

$$$$
SWF005101
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1391    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  2  0  0  0  0
 10 11  1  6  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005101

>  <SMILES>
COCCNC(=O)[C@H]1CN(Cc2ccccc2C)[C@@H]2CCO[C@H]12

$$$$
SWF005102
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
    6.1725    5.1106   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8833    6.4314   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3840    6.3866   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8411    4.4196   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5428    4.5005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5512    2.9479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6114    5.5532   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2616    4.7298   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0573    5.1541   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3179    5.0400   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7032    2.6510   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4970    3.5507   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8763    2.9612   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0553    1.4719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 11 18  1  0  0  0  0
 13 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
 20 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 25 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 28 31  1  0  0  0  0
 10 12  1  1  0  0  0
 14 19  1  0  0  0  0
 20 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005102

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)N(C)C)C3)Oc3ccccc3S2(=O)=O)cc1

$$$$
SWF005103
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.6513   -2.6970   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -4.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0057   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9763   -4.7847   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5943   -4.7847   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3366   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2853   -5.7358   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2853   -5.7358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005103

>  <SMILES>
Cc1cc(C(=O)N2CC[C@H]3[C@H]2CCN3Cc2cccnc2)no1

$$$$
SWF005104
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    4.1637   -5.7990   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1232   -3.5998   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8941   -8.3703   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6732   -6.7195   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3038   -8.0805   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
 10  6  1  6  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005104

>  <SMILES>
Cn1cc(N2CC3(COCCN(C(=O)C4CC4)C3)OCC2=O)cn1

$$$$
SWF005105
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005105

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CC(=O)N(Cc2cccnc2)C3)c1

$$$$
SWF005106
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    4.3301   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1665    7.1808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3005    7.6808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  2  0  0  0  0
 19 17  1  1  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005106

>  <SMILES>
COc1ccc(F)cc1-c1ccc2nc(C3CCCN(C(=O)C4CC4)C3)nn2c1

$$$$
SWF005107
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9826   -3.1317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5933  -10.6165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2942  -12.8665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005107

>  <SMILES>
Cc1cccc(CN2CCC3(CC(C(=O)NCC(C)C)=NO3)C2)c1

$$$$
SWF005108
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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   10.3923   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005108

>  <SMILES>
CN(C)S(=O)(=O)N1C[C@H]2OCC[C@H]2[C@H](C(=O)NCc2ccco2)C1

$$$$
SWF005109
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   10.7465    0.0342   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.9600   -0.8474   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6282    1.2478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1200    1.0910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0181    2.6181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0016    2.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.3915    3.6748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 27 29  2  0  0  0  0
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 13 15  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005109

>  <SMILES>
CN(Cc1ccccc1)C1COC2(CCN(S(=O)(=O)c3ccc(F)cc3)CC2)C1

$$$$
SWF005110
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.5263   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005110

>  <SMILES>
COCC(=O)NC1CC2(CCN(CCF)CC2)Oc2ccccc21

$$$$
SWF005111
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005111

>  <SMILES>
COc1cccc(NC2COC3(CCN(C(=O)C4CC4)CC3)C2)c1

$$$$
SWF005112
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005112

>  <SMILES>
O=C(c1ccoc1)N1CCn2cc(CNc3ccccn3)nc2C1

$$$$
SWF005113
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005113

>  <SMILES>
Cc1ccc(CN2CC3CC(C(=O)Nc4cccnc4)C(C2)O3)o1

$$$$
SWF005114
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005114

>  <SMILES>
Cc1ncsc1CN1CC[C@@]2(C[C@H](Nc3ncccn3)CCO2)C1

$$$$
SWF005115
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005115

>  <SMILES>
CS(=O)(=O)N1CCO[C@@H]2CN(C(=O)c3ccoc3)CC[C@@H]2C1

$$$$
SWF005116
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005116

>  <SMILES>
COCCNC(=O)c1cc2c(c3ccccc3n2CC2CC2)n1C(=O)N(C)C

$$$$
SWF005117
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005117

>  <SMILES>
Cc1nc(N2CCOCC2)nc2c1CCN(C(=O)c1ccc3c(c1)OCO3)CC2

$$$$
SWF005118
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005118

>  <SMILES>
CCN1C(=O)C(c2ccccc2)CC12CCN(CCO)CC2

$$$$
SWF005119
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005119

>  <SMILES>
CN1Cc2nnc(C(=O)NC3CCCCC3)n2CC12CCN(Cc1cnn(C)c1)C2

$$$$
SWF005120
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005120

>  <SMILES>
COc1cccc(CN2CCCC3(CCN(C(=O)c4cccc(OC)c4)C3)C2)c1

$$$$
SWF005121
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005121

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCO[C@]2(CCN(C(=O)c3ccccc3)C2)C1

$$$$
SWF005122
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    5.8633    5.1170   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005122

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3cscn3)C[C@H]2C)C1=O

$$$$
SWF005123
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
  5 11  2  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005123

>  <SMILES>
Cn1cc(N2CCC3(CCCN(Cc4nccn4C)C3)C2=O)cn1

$$$$
SWF005124
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -5.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005124

>  <SMILES>
O=C(c1ccncn1)N1CCC2(CC1)CC(Nc1ncccn1)CCO2

$$$$
SWF005125
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.7942    0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5442   -0.5490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0442    2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005125

>  <SMILES>
CS(=O)(=O)NC1COCCC12CCN(C(=O)c1cocn1)CC2

$$$$
SWF005126
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.6295    2.1728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295    1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634    0.6728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955    0.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8499    1.0796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3615    1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  9 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005126

>  <SMILES>
O=C(c1ncccn1)N1CC[C@]2(C[C@@H](OCC3CCC3)CO2)C1

$$$$
SWF005127
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.1636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6172    0.9774   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    2.5865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005127

>  <SMILES>
COc1cccc(CN2CCCC3(CCN(C(=O)c4ccc[nH]4)C3)C2)c1

$$$$
SWF005128
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2163    0.4514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8330    0.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6717    1.2900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8796    2.2682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005128

>  <SMILES>
Cn1cc(CN2CC3(C2)OCCC3CCOc2cccnc2)cn1

$$$$
SWF005129
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005129

>  <SMILES>
Cc1ccc(N2CCCC3(CCN(c4ncccn4)C3)C2)nn1

$$$$
SWF005130
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.6618   -4.6649   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6581   -3.5502   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1946   -4.9768   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7765   -3.6612   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9737   -6.1322   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -3.7397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8550   -2.1633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8589   -7.1358   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4002   -6.5957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.1708   -8.6031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5974   -9.0666   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005130

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CC3(C2)OCCC3COCC2CC2)cc1

$$$$
SWF005131
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6950   -0.7963   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005131

>  <SMILES>
Cc1ccccc1N1CC2(CCN(C(=O)c3ccoc3C)C2)CC1=O

$$$$
SWF005132
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005132

>  <SMILES>
CN(Cc1ccccn1)C1COC2(CCCN(C(=O)C3CC3)C2)C1

$$$$
SWF005133
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  2  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005133

>  <SMILES>
Cc1nc(CN2CCc3ncnc(C4CC4)c3CC2)cs1

$$$$
SWF005134
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005134

>  <SMILES>
COc1ccc(N2CC3(CCN(C(=O)C4CC4)C3)CC2=O)cc1

$$$$
SWF005135
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1391    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 10 11  1  6  0  0  0
 13 14  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005135

>  <SMILES>
COCCNC(=O)[C@H]1CN(Cc2ncccc2C)[C@@H]2CCO[C@H]12

$$$$
SWF005136
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9106   -2.4839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2527   -3.2370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9016   -2.6182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0681   -1.4192   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 24 27  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005136

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(C(=O)C3CCC3)C[C@H]1CN(c1ncccn1)C2

$$$$
SWF005137
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  2  0  0  0  0
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 14 18  1  1  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 20 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005137

>  <SMILES>
O=C(c1ccccn1)N1C[C@H]2[C@@H](C1)c1ccccc1[C@@H]2N1CCOCC1

$$$$
SWF005138
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005138

>  <SMILES>
CNC(=O)NCC1CCC2(CCN(Cc3ccccc3)CC2)CO1

$$$$
SWF005139
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 19 21  1  0  0  0  0
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 23 25  2  0  0  0  0
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  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005139

>  <SMILES>
O=C1N(CC2CCOCC2)CCCC12CCN(Cc1ccccn1)CC2

$$$$
SWF005140
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
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  5 10  1  0  0  0  0
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 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
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 25 27  1  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF005140

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4ccco4)CC3)CC[C@@]2(C(=O)N2CCCC2)C1

$$$$
SWF005141
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  1  0  0  0
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 13 16  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005141

>  <SMILES>
O=C(NCc1ccccn1)[C@]12COC[C@H]1CN(Cc1ccoc1)C2

$$$$
SWF005142
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
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 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005142

>  <SMILES>
COCCN1CCOCC2(CCCN(Cc3cccs3)C2)C1

$$$$
SWF005143
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
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 12 10  1  1  0  0  0
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 13 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005143

>  <SMILES>
Cc1nc(C(=O)N2C[C@H]3Cn4c(-c5ccncc5)cnc4[C@H]3C2)cs1

$$$$
SWF005144
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005144

>  <SMILES>
O=C(NC[C@@H]1OC[C@H]2CN(Cc3ccccc3)CC[C@H]21)C1CC1

$$$$
SWF005145
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.9527    5.9978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005145

>  <SMILES>
CN(C)C[C@]12COC[C@H]1CN(Cc1ccc3c(c1)OCO3)C2

$$$$
SWF005146
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005146

>  <SMILES>
Cn1ccnc1CN1CCC2(COCCN(Cc3ccoc3)C2)C1

$$$$
SWF005147
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005147

>  <SMILES>
COc1ccc(N(C)c2ccc3ccc(C(=O)N4CCCC4)cn23)cc1

$$$$
SWF005148
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005148

>  <SMILES>
O=C1N(Cc2ccncc2)CCOC12CN(Cc1ccncc1)CC2c1cccnc1

$$$$
SWF005149
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005149

>  <SMILES>
COc1ccc(F)cc1-c1ccc2nc(C3CCCN(CC4CC4)C3)nn2c1

$$$$
SWF005150
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 21 22  1  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005150

>  <SMILES>
CC(C)CNC(=O)C1CC2CN(Cc3cnn(C)c3)CC1O2

$$$$
SWF005151
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 30 33  2  0  0  0  0
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 22 23  2  0  0  0  0
 31 33  1  0  0  0  0
M  END
>  <HTSID>
SWF005151

>  <SMILES>
COc1cccc(CNC(=O)C2Cn3ccnc3C3(CCN(C(=O)c4ccccn4)CC3)O2)c1

$$$$
SWF005152
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005152

>  <SMILES>
O=C(C1CCCO1)N1CCC2(CC1)COCCN(Cc1ccncc1)C2

$$$$
SWF005153
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005153

>  <SMILES>
COCCN1C(=O)C(c2ccccc2)CC12CCN(Cc1ccco1)CC2

$$$$
SWF005154
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005154

>  <SMILES>
O=C(NCc1cccs1)C1CC12CCN(C(=O)Cc1cccs1)C2

$$$$
SWF005155
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.6618   -4.6649   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1983   -6.0915   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6655   -5.7796   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2352   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3530   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 18 20  1  0  0  0  0
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  7  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005155

>  <SMILES>
CCS(=O)(=O)N1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF005156
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    5.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005156

>  <SMILES>
Cc1ccccc1S(=O)(=O)N1CC[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF005157
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6914   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6914   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 11 13  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005157

>  <SMILES>
CCS(=O)(=O)N1CC[C@@H]2OCCN(Cc3ccncc3)[C@H]2C1

$$$$
SWF005158
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4423   -5.2943   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1707   -7.8781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 17 20  1  0  0  0  0
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 22 20  1  1  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005158

>  <SMILES>
Cc1cccc(CN2CC3(CCN(C(=O)C4CCOC4)CC3)CC2=O)c1

$$$$
SWF005159
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.0029    3.8974   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2598    3.2283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8690    3.3974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6611    2.4193   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 11  1  6  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005159

>  <SMILES>
O=C(Cc1ccsc1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF005160
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005160

>  <SMILES>
COCC(=O)N1CCC2(CC1)CN(Cc1ccsc1)CC2COC

$$$$
SWF005161
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 20  2  0  0  0  0
 19 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005161

>  <SMILES>
COCC1CC2(CCN(C(=O)CCc3ccccc3)CC2)CO1

$$$$
SWF005162
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.5810   -3.5937   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005162

>  <SMILES>
COC[C@@]12CCO[C@@H]1CCN(S(=O)(=O)c1cccc(F)c1)C2

$$$$
SWF005163
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.8235   -2.8009   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  6  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005163

>  <SMILES>
CC(C)C(=O)N1CC2(C1)OCCC2CCOc1ccccn1

$$$$
SWF005164
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    7.4128    2.9345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 13 14  2  0  0  0  0
M  END
>  <HTSID>
SWF005164

>  <SMILES>
CC(C)NC(=O)Cc1cn2c(n1)C(C)N(S(C)(=O)=O)CC2

$$$$
SWF005165
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005165

>  <SMILES>
COCC1CC2(CCN(C(=O)Cc3cccs3)CC2)CO1

$$$$
SWF005166
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005166

>  <SMILES>
Cc1nc(CN2CCO[C@@H]3CN(C(=O)c4ccco4)C[C@@H]3C2)cs1

$$$$
SWF005167
Actelion Java MolfileCreator 1.0

 33 38  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005167

>  <SMILES>
O=c1c2c(nc3n1CC1(CCN(Cc4cccnc4)CC1)C3)CCN(Cc1cccnc1)C2

$$$$
SWF005168
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005168

>  <SMILES>
CS(=O)(=O)N1CCC2(CC1)COC(COCc1cccnc1)C2

$$$$
SWF005169
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005169

>  <SMILES>
CC1c2ncc(CNC(=O)C3CC3)n2CCN1Cc1cccnc1

$$$$
SWF005170
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005170

>  <SMILES>
CCS(=O)(=O)N1CCOC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF005171
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1665    1.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005171

>  <SMILES>
O=C(Cc1ccccc1)N1C[C@@H]2COC[C@]2(COCC2CC2)C1

$$$$
SWF005172
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.8891    1.4815   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  1  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005172

>  <SMILES>
CC(=O)N1[C@H](Cn2cncn2)C[C@@H]2CN(C(=O)c3ccoc3)CC[C@@H]21

$$$$
SWF005173
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 10 13  1  0  0  0  0
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 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005173

>  <SMILES>
O=C([C@H]1CCCO1)N1CCOC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF005174
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005174

>  <SMILES>
CCS(=O)(=O)N1CCC2(CCCN(Cc3nccs3)C2)C1

$$$$
SWF005175
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005175

>  <SMILES>
COc1cccc(CN2C[C@@H]3COC[C@]3(CN3CCOCC3)C2)c1

$$$$
SWF005176
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005176

>  <SMILES>
Cc1cccc(N2CC3(CCN(C(=O)CC4CC4)C3)CC2=O)c1

$$$$
SWF005177
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 21 22  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005177

>  <SMILES>
Cn1cc(CN2CC3CC(C(=O)NCC4CC4)C(C2)O3)cn1

$$$$
SWF005178
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    7.3493   -3.7386   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 16 19  1  0  0  0  0
 17 18  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005178

>  <SMILES>
Cc1ccc(NC(=O)N2CCCC3(CC(C(=O)NCc4cccnc4)=NO3)C2)cc1

$$$$
SWF005179
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 24 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF005179

>  <SMILES>
COCC1CC2(CCN(Cc3cccnc3OC)CC2)CN1C(C)C

$$$$
SWF005180
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 22 23  1  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005180

>  <SMILES>
COCC1CCN(C)C2(C1)CN(C(=O)Cc1ccc(C)cc1)C2

$$$$
SWF005181
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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   -1.6338   -3.4817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3029   -4.2248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  2  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005181

>  <SMILES>
O=C(NCC1CCC2C1OCCN2Cc1cccnc1)c1ccco1

$$$$
SWF005182
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0686   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.1037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3834   -1.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2494   -1.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005182

>  <SMILES>
CN(C)C(=O)CN1C(=O)C[C@@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF005183
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2556    0.8638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7969    0.3236   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5675    2.3310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1088    1.7909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3059    4.2618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.5857    5.6523   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 14  1  0  0  0  0
 21 24  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005183

>  <SMILES>
COCC1CN(Cc2cccnc2)CC12CCN(Cc1ccccn1)CC2

$$$$
SWF005184
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2791    0.8163   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5981    5.0777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8669    0.0073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7321    5.5777   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  6  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  8  9  1  0  0  0  0
 15 17  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005184

>  <SMILES>
CCN1C[C@H](COC)[C@]2(CCN(C(=O)COc3ccccc3)C2)C1

$$$$
SWF005185
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2681    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005185

>  <SMILES>
COCCN1CC[C@]2(CN(Cc3cnn(C)c3)C[C@H]2C)C1=O

$$$$
SWF005186
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   13.1383    2.3929   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.1872    2.0839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3782    2.6717   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.8782    1.1329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5692    2.0839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8782    1.1329   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6182    2.3929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3969    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005186

>  <SMILES>
CN(C)CCNC(=O)c1nnc2n1CC1CN(Cc3ccc(Cl)s3)CC1C2

$$$$
SWF005187
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005187

>  <SMILES>
CCN(CC)CC1CN(C(=O)c2cccc(C)c2)Cc2ccnn21

$$$$
SWF005188
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.4385   -6.3653   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005188

>  <SMILES>
c1ccc(COCC2CC3OCCN(Cc4cccs4)C3C2)nc1

$$$$
SWF005189
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005189

>  <SMILES>
O=C([C@H]1CCCO1)N1CCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF005190
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005190

>  <SMILES>
Cc1cccc(CN2CCCC3(CCN(C(=O)c4cccn4C)C3)C2)n1

$$$$
SWF005191
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005191

>  <SMILES>
CC1CC1C(=O)N1Cc2ccnn2C(CC(=O)N2CCOCC2)C1

$$$$
SWF005192
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005192

>  <SMILES>
O=C(Cc1ccsc1)N1CCOC(Cn2nnc3c(N4CCCC4)ncnc32)C1

$$$$
SWF005193
Actelion Java MolfileCreator 1.0

 33 38  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005193

>  <SMILES>
O=c1c2c(nc3n1CC1(CCN(Cc4ccccn4)CC1)C3)CCN(Cc1cccnc1)C2

$$$$
SWF005194
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005194

>  <SMILES>
Cc1nc(COC2CCOC3(C2)CN(C(=O)c2ccn(C)n2)C3)cs1

$$$$
SWF005195
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005195

>  <SMILES>
Cn1ccnc1CN1CCC2(CC1)CN(c1cccnc1)c1ccccc12

$$$$
SWF005196
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF005196

>  <SMILES>
Cc1nc(CN2CCC3C2CC(=O)N3CC(=O)N(C)C)cs1

$$$$
SWF005197
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1106    2.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  8  1  1  0  0  0
  9 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
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 25 27  2  0  0  0  0
 27 28  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005197

>  <SMILES>
Cc1ccc(CN2CCC3(CC(C(=O)N(C)Cc4ccccn4)=NO3)C2)cc1

$$$$
SWF005198
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0327   -1.4945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0109   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5109   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  1  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF005198

>  <SMILES>
CCN(CC)CC1CN(C(=O)c2occc2C)Cc2ccnn21

$$$$
SWF005199
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.8192   -7.3203   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4883   -6.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF005199

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(Cc1ccc(F)cc1)C2C

$$$$
SWF005200
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7105    0.2862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2661   -6.9746   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 19  1  0  0  0  0
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 22 27  2  0  0  0  0
 25 28  1  0  0  0  0
 25 29  1  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 26  1  0  0  0  0
 23 27  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005200

>  <SMILES>
O=C(C1CC1)N1CC(c2cccnc2)C2(C1)OCCN(Cc1ccccn1)C2=O

$$$$
SWF005201
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9578    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8365    2.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005201

>  <SMILES>
CCCC(=O)N1CC2(CC(OCc3ccccn3)CCO2)C1

$$$$
SWF005202
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733   -3.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6720   -4.4781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665   -4.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF005202

>  <SMILES>
CCN(CC)CC1CN(C(=O)CCC(C)C)Cc2ccnn21

$$$$
SWF005203
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9841    0.1157   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2557   -2.4681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6138    0.7258   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8274    1.6075   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4759    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7475   -2.3113   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3576   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6292   -3.5249   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1209   -3.3681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0191   -4.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7691   -6.1942   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5518   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7654   -7.3090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3950   -6.6988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005203

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(C(=O)c2cc[nH]n2)CCC3(F)F)cs1

$$$$
SWF005204
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.2501    5.9918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7173    6.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4636    3.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4673    5.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.2080   -1.0037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1061   -2.2172   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5979   -2.3740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF005204

>  <SMILES>
CN(C)C(=O)NCC1CN(Cc2cccs2)Cc2ccnn21

$$$$
SWF005205
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -3.2537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1800   -2.9418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8527   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6435   -1.5152   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1837   -4.0565   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1027   -7.2221   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -8.5924   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6109   -7.3789   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -9.5961   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -8.8461   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
 10  8  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005205

>  <SMILES>
CC(=O)N1C(Cn2cccn2)C[C@@H]2CN(Cc3ccsc3)CC[C@@H]21

$$$$
SWF005206
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    6.4355    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9835    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5003    1.2677   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8689   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0841   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4169   -1.7435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8041    0.8256   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1836   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6008   -2.4694   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6669   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9001   -1.9670   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2874    0.6020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0715   -4.7619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8354   -0.7943   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8322   -5.6069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988   -5.1647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3786   -6.2643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 10 13  1  1  0  0  0
 15 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005206

>  <SMILES>
CC(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(CCN(C)C)[C@H]2CC1

$$$$
SWF005207
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
    7.4623   -1.6594   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4678   -1.7639   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0501   -2.4684   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0611   -2.6775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6434   -3.3819   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0665   -2.7820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6488   -3.4865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5665   -3.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 12  2  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005207

>  <SMILES>
Cn1cc(CN2CC3Cn4c(-c5cccnc5)cnc4C3C2)cn1

$$$$
SWF005208
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  1  0  0  0
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  9 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF005208

>  <SMILES>
CS(=O)(=O)N[C@H]1COC[C@@H]2CN(Cc3nccs3)C[C@@H]21

$$$$
SWF005209
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 16  1  0  0  0  0
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 12 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005209

>  <SMILES>
Cn1cc(-c2nc3c(c(NC4CC4)n2)CN(Cc2ccncc2)CC3)cn1

$$$$
SWF005210
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 11 12  1  0  0  0  0
 14 17  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF005210

>  <SMILES>
CCC(=O)NC1CC2(CCN(Cc3ccco3)CC2)Oc2ccccc21

$$$$
SWF005211
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 25 28  2  0  0  0  0
 26 29  2  0  0  0  0
  9 10  2  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005211

>  <SMILES>
CCNC(=O)c1nnc2n1CC1(CC2)CCN(C(=O)Cc2ccccc2C)CC1

$$$$
SWF005212
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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    2.9841    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1750    4.1266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0411    4.6266   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3090    4.6266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3090    5.6266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1750    6.1266   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4430    6.1266   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4230    5.6266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005212

>  <SMILES>
COc1cc(N2CC[C@@H]3[C@@H]2CCN3C(=O)c2ccco2)ncn1

$$$$
SWF005213
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7040   -1.7788   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9609   -2.4479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5519   -3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0173   -2.6558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6519   -3.3990   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1452   -4.7614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5464   -3.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7329   -5.5704   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1342   -4.5523   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7275   -5.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3152   -6.2749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9085   -7.1885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3098   -6.1704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4963   -7.9975   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8975   -6.9794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4908   -7.8929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005213

>  <SMILES>
CCCNC(=O)c1cc(-c2cnc(-c3ccccc3)nc2)cn1CC1CC1

$$$$
SWF005214
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2437   -1.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4347   -2.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9128   -2.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4128   -3.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005214

>  <SMILES>
CN(C)c1nc(N2CCCC2)nc2c1CN(C(=O)Cc1ccsc1)CC2

$$$$
SWF005215
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9609   -2.4479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0173   -2.6558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5464   -3.7433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1342   -4.5523   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7275   -5.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3152   -6.2749   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9085   -7.1885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3098   -6.1704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005215

>  <SMILES>
CN(C)c1ncc(-c2cc(C(=O)NCCO)n(CC3CC3)c2)cn1

$$$$
SWF005216
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721    0.9748   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5049    1.2867   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4393   -1.5665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8952   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6240   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8952   -5.3083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8658   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -1.5583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -0.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -1.5583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005216

>  <SMILES>
Cc1nc(CN2CC3CN(C(=O)c4ccncc4)CC3S2(=O)=O)cs1

$$$$
SWF005217
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    7.6782    3.3711   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8861    2.3929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1430    1.7238   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8372    2.0839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1648    1.9317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2475    0.7293   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1462    1.1329   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.6462    2.6717   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6648    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3339    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1462    1.1329   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5584    0.3239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4552    2.0839   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6867    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  6  0  0  0
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 16 18  1  0  0  0  0
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 21 22  2  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
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 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005217

>  <SMILES>
Cn1nccc1C(=O)N1C[C@@H]2Cc3nnc(C(=O)NCc4ccccc4)n3C[C@@H]2C1

$$$$
SWF005218
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
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  8  6  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  2  0  0  0  0
M  END
>  <HTSID>
SWF005218

>  <SMILES>
CC(C)CNC(=O)c1cn2c(nc1=O)C1(CCN(S(C)(=O)=O)C1)CC2

$$$$
SWF005219
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  2  0  0  0  0
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 13 18  1  0  0  0  0
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 15 20  2  0  0  0  0
 16 21  2  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
 18 24  1  0  0  0  0
 19 25  2  0  0  0  0
 22 26  1  0  0  0  0
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 24 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  1  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 25  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005219

>  <SMILES>
Cn1cnc(C2CN(C(=O)c3ccn(C)n3)CC23CCN(Cc2cccnc2)C3=O)c1

$$$$
SWF005220
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 25  1  0  0  0  0
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 25 28  2  0  0  0  0
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 14 15  2  0  0  0  0
 17 18  1  0  0  0  0
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 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005220

>  <SMILES>
COc1ccccc1-c1cnc2n1CCC21CCN(C(=O)Cc2ccco2)C1

$$$$
SWF005221
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005221

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(C(=O)c2ccncc2)C3)cs1

$$$$
SWF005222
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 25 26  1  0  0  0  0
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 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005222

>  <SMILES>
CCOC1CC2(CCN(C(=O)c3cccnc3)CC2)c2cc(C)ccc21

$$$$
SWF005223
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005223

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4ccco4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF005224
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005224

>  <SMILES>
CN1C[C@H]2C3(CCN(Cc4cccnc4)CC3)CC[C@@]2(C(=O)N(C)C)C1

$$$$
SWF005225
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
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  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005225

>  <SMILES>
CS(=O)(=O)NCC1CN(C(=O)COc2ccccc2)Cc2ccnn21

$$$$
SWF005226
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 11 18  2  0  0  0  0
 13 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
 18 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 10 12  1  1  0  0  0
 14 19  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005226

>  <SMILES>
CC(=O)N1CCC2(C1)CN(Cc1csc(C)n1)S(=O)(=O)c1ccccc1O2

$$$$
SWF005227
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005227

>  <SMILES>
CS(=O)(=O)NCc1cn2c(n1)CN(Cc1cccnc1)CC2

$$$$
SWF005228
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.9608   -4.3909   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5788   -4.3909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  1  0  0  0
 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005228

>  <SMILES>
Cc1ccnc(OCC[C@H]2CO[C@H]3CN(C(=O)c4cscn4)C[C@@H]23)n1

$$$$
SWF005229
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF005229

>  <SMILES>
Cc1nc(CN2CCC3(C2)CN(C(=O)c2ccc[nH]2)C3)cs1

$$$$
SWF005230
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   11.3566   -1.3361   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 12  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005230

>  <SMILES>
COCC1CC2(CCN(C(=O)Cc3ccccc3C)CC2)CO1

$$$$
SWF005231
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.8481    7.5583   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3846    6.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  6  0  0  0
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 18 20  2  0  0  0  0
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 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005231

>  <SMILES>
COCC(=O)NC1COCCC12CCN(Cc1ccsc1)CC2

$$$$
SWF005232
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF005232

>  <SMILES>
CCN(CC)Cc1cn2c(n1)CN(S(=O)(=O)c1ccccc1)CC2

$$$$
SWF005233
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7  9  1  0  0  0  0
 10 12  1  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005233

>  <SMILES>
Cn1cc(CN2CCOC3(CCCN(c4ccccn4)C3)C2)cn1

$$$$
SWF005234
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  1  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  1  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 25 28  1  0  0  0  0
 26 29  2  0  0  0  0
 28 30  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 24 27  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005234

>  <SMILES>
CN1C(=O)[C@H]2CN(Cc3cccnc3)C[C@H]2C12CCN(C(=O)c1ccccc1)CC2

$$$$
SWF005235
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.6014   -7.1269   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005235

>  <SMILES>
COCCN1CCO[C@@H]2CN(C(=O)Cc3ccsc3)CC[C@@H]2C1

$$$$
SWF005236
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7698    5.6010   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  8  6  1  6  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005236

>  <SMILES>
CS(=O)(=O)N1CCC(F)(F)C2(CCN(c3cnccn3)C2)C1

$$$$
SWF005237
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005237

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2OCCN(Cc3cccnc3)[C@H]2C1

$$$$
SWF005238
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.3799   -0.6235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3799    1.6235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9783    2.1828   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9672    2.0338   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8488    4.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005238

>  <SMILES>
Cc1cnc(N2CC[C@@H]3CN(c4ccc(C)nn4)CCO[C@@H]3C2)nc1

$$$$
SWF005239
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.9824   -4.0881   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7745   -3.1099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5177   -2.4408   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8235   -2.8009   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0144   -3.3887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4856   -1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7946   -2.8009   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005239

>  <SMILES>
O=C(c1cocn1)N1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF005240
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    3.8147    0.0296   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  4 10  1  0  0  0  0
  5 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
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 22 26  1  0  0  0  0
 23 27  1  0  0  0  0
 24 28  1  0  0  0  0
 26 29  2  0  0  0  0
 27 30  2  0  0  0  0
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 10 11  1  0  0  0  0
 21 25  1  0  0  0  0
 22 23  2  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005240

>  <SMILES>
COc1cccc(CN2C[C@@]3(F)CN(Cc4cc5ccccc5o4)C[C@@]3(F)C2=O)c1

$$$$
SWF005241
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    9.4975    2.4982   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.7544    1.8291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.0602    1.4690   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005241

>  <SMILES>
C[C@@H]1CN(c2ncc(F)cn2)C[C@]12CCN(CC(=O)N(C)C)C2=O

$$$$
SWF005242
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
  4  7  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005242

>  <SMILES>
CO[C@@H]1CCN(CC2CC2)[C@@H]2CN(Cc3ccncc3)C[C@@H]21

$$$$
SWF005243
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    9.2492   -3.6511   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0413   -2.6730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3832   -4.1511   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6400   -3.4820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <HTSID>
SWF005243

>  <SMILES>
CC(C)N(C)Cc1cn2c(n1)CN(Cc1ccsc1)CC2

$$$$
SWF005244
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.6295    2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6420    3.7898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3851    4.4589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6909    4.0988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1772    5.4370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4830    5.0769   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2261    5.7460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0182    6.7242   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0672    7.0332   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005244

>  <SMILES>
COc1ccc(N2CC3(CCN(C(=O)CC4CC4)C3)CC2=O)cc1

$$$$
SWF005245
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1836    5.2348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6106    5.2348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0288    2.5947   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4187    1.2244   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3971    7.6165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3004    0.0109   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0981    8.3665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481    9.6656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    8.3665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  5  1  1  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 17  1  0  0  0  0
 19 22  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005245

>  <SMILES>
COC[C@@H]1CN(CC2CC2)C[C@@]12CCN(C(=O)COc1ccccc1)C2

$$$$
SWF005246
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    7.7942   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2817   -5.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7087   -5.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7452   -6.8083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9952  -10.6165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2942  -11.3665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2942  -12.8665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5933  -10.6165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5933  -13.6165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8923  -11.3665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8923  -12.8665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 12  8  1  1  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005246

>  <SMILES>
CN(C)C1CCN(C(=O)C2=NOC3(CCN(Cc4ccccc4)C3)C2)CC1

$$$$
SWF005247
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -4.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -5.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 28 31  1  0  0  0  0
  7 12  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005247

>  <SMILES>
Cc1ccc(N2CCN(CC3CC3)C3(CCN(Cc4cccc(C)n4)CC3)C2=O)cn1

$$$$
SWF005248
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.9407   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5340   -1.4390   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 15  2  0  0  0  0
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 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF005248

>  <SMILES>
Cc1ccc(CN2CC3(CCN(C(=O)c4cccnc4)C3)C2)o1

$$$$
SWF005249
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 14 20  1  0  0  0  0
 15 21  1  0  0  0  0
 18 22  1  0  0  0  0
 18 23  2  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005249

>  <SMILES>
Cn1cc(CN2CCc3ncn(C)c3C2COCc2ccccc2)cn1

$$$$
SWF005250
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -5.0777   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005250

>  <SMILES>
Cc1occc1C(=O)N1CC2CN(Cc3cccnc3)CC2C1

$$$$
SWF005251
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7221    0.0444   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1893   -0.2674   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9758   -2.3693   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005251

>  <SMILES>
COc1ccc(CN2CCC3(CC(n4cnnc4)CO3)C2)cc1

$$$$
SWF005252
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
   -0.5368    1.4222   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3449    2.6357   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5867    1.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.6165    5.2196   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 13  1  0  0  0  0
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 13 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8  9  1  0  0  0  0
 15 19  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005252

>  <SMILES>
COC[C@@H]1CN(CC2CC2)C[C@@]12CCN(C(=O)Cc1ccccc1)C2

$$$$
SWF005253
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 15 13  1  1  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005253

>  <SMILES>
Cc1nc([C@@H]2C[C@@H]3CCN(C(=O)Cc4cccs4)C[C@H]3O2)no1

$$$$
SWF005254
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  2  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005254

>  <SMILES>
COc1ccc(N2CC3(CCN(C(=O)[C@H]4CCCO4)C3)CC2=O)cc1

$$$$
SWF005255
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
  9 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005255

>  <SMILES>
Cc1nc(CN2C(=O)CC[C@@H]3[C@H]2CCN3C2CCOC2)cs1

$$$$
SWF005256
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 12 15  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005256

>  <SMILES>
COc1ccc(C(=O)N2CCc3nc(N4CCOCC4)nc(C)c3CC2)cc1

$$$$
SWF005257
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
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 17 18  2  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005257

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)C4(F)CCC4)C[C@H]32)cs1

$$$$
SWF005258
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005258

>  <SMILES>
COCC(=O)N1CCC2(CC1)CC(=O)N(Cc1cccc(C)c1)C2

$$$$
SWF005259
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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 11 13  2  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005259

>  <SMILES>
COCC(=O)N1C[C@H]2[C@@H](C1)c1ccccc1[C@@H]2N(C)C(C)C

$$$$
SWF005260
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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 10  9  1  6  0  0  0
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 13 15  2  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005260

>  <SMILES>
CN(C)Cc1noc2c1CC(NCc1ccccc1F)CC2

$$$$
SWF005261
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.0399   -4.7577   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6277   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0889   -4.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6277   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0889   -3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1277   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1222   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7210   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  1  0  0  0
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 19 21  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005261

>  <SMILES>
CN(C)CCN1CCO[C@H]2CN(C(=O)c3cccs3)C[C@H]21

$$$$
SWF005262
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826   -3.1317   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4097   -3.1317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9826   -5.9848   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.1000   -4.2120   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6690   -8.9684   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005262

>  <SMILES>
COCCn1c(C(=O)NCCO)cc2c1c1ccccc1n2C

$$$$
SWF005263
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5372    1.9182   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0470   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9863   -3.6989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -3.3107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0333   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352   -6.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -8.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 11  2  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005263

>  <SMILES>
Cn1cccc1C(=O)NCC1CCC2(CN(Cc3cccnc3)C2)OC1

$$$$
SWF005264
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   10.4932   -5.3083   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4932   -3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1942   -3.0583   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7923   -3.0583   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0374   -1.5665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0058   -0.6766   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5665   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.4239    1.9635   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  9  6  1  6  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF005264

>  <SMILES>
CNC(=O)C[C@@H]1C[C@H]2CN(C(=O)Cc3ccn(C)n3)C[C@H]2O1

$$$$
SWF005265
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  8  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005265

>  <SMILES>
O=C(NCC[C@@]12CCO[C@@H]1CCN(Cc1cccnc1)C2)c1ccno1

$$$$
SWF005266
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005266

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CC1)CC(Nc1ncccn1)CO2

$$$$
SWF005267
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
  7  8  1  0  0  0  0
 14 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005267

>  <SMILES>
COCCN1CCCC2(CN(Cc3ccc(O)c(F)c3)CC(F)(F)C2)C1=O

$$$$
SWF005268
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005268

>  <SMILES>
CCC(=O)N1CCC2(CC1)CC(COC)N(Cc1cccnc1)C2

$$$$
SWF005269
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8660    4.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005269

>  <SMILES>
CCC(=O)N1CCc2nc(N3CCCC3)nc(NC(C)C)c2C1

$$$$
SWF005270
Actelion Java MolfileCreator 1.0

 31 35  0  0  1  0  0  0  0  0999 V2000
   10.7909    1.1325   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0024   -0.1435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 28  2  0  0  0  0
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 27 31  2  0  0  0  0
 12 16  1  0  0  0  0
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 18 19  1  0  0  0  0
 28 31  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005270

>  <SMILES>
O=C(c1cccnc1)N1CCC[C@@]2(C(=O)NCC3CC3)CN(c3ncccn3)C[C@@H]2C1

$$$$
SWF005271
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    4.2432   -2.5664   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9969   -1.2609   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 21 24  1  0  0  0  0
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 23 26  1  0  0  0  0
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 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
  4  6  1  0  0  0  0
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 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005271

>  <SMILES>
Cc1nc(CN2CCC3(CN(C4CCC4)CC3c3cn(C(C)C)cn3)C2=O)cs1

$$$$
SWF005272
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005272

>  <SMILES>
CC(C)NC(=O)c1cc2c(c3ccccc3n2C(C)C)n1C(=O)N(C)C

$$$$
SWF005273
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005273

>  <SMILES>
Cc1cc(CN2C(=O)C[C@H]3[C@@H]2CCN3Cc2cccnc2)n(C)n1

$$$$
SWF005274
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005274

>  <SMILES>
Cc1nc(CN2CCC3(CN(C(=O)C4CCC4)CC3c3cn(C(C)C)cn3)C2=O)cs1

$$$$
SWF005275
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005275

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(c2ncccn2)C3)n1

$$$$
SWF005276
Actelion Java MolfileCreator 1.0

 21 22  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005276

>  <SMILES>
C=CC(=O)N1CC[C@@H](NS(C)(=O)=O)[C@@H]1Cc1ccccc1

$$$$
SWF005277
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005277

>  <SMILES>
O=C1N(Cc2ccncc2)CCOC12CN(Cc1cccc(F)c1)CC2c1cccnc1

$$$$
SWF005278
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005278

>  <SMILES>
c1cncc(CN2CCOC3(CCCN(c4cnccn4)C3)C2)c1

$$$$
SWF005279
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005279

>  <SMILES>
Cc1ccccc1CN1CCC2(COCc3cnc(N4CCOCC4)nc32)C1

$$$$
SWF005280
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005280

>  <SMILES>
CS(=O)(=O)N[C@@H]1CN(Cc2cccnc2)C[C@@H]2CCCO[C@@H]21

$$$$
SWF005281
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF005281

>  <SMILES>
CN(C)c1nccc(N2CCC3(CC2)CN(C(=O)Cc2cccs2)Cc2ccccc23)n1

$$$$
SWF005282
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.4480    2.5865   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005282

>  <SMILES>
Cc1ccsc1C(=O)N1CCC2(CC2C(=O)NCc2ccncc2)C1

$$$$
SWF005283
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005283

>  <SMILES>
COc1cccc(NC(=O)c2cnc(-c3noc4cc(N5CCCCC5)ccc34)s2)c1

$$$$
SWF005284
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005284

>  <SMILES>
O=S(=O)(c1ccccc1)N1CC2CN(Cc3ccc(-c4ccccc4)cc3)C2C1

$$$$
SWF005285
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005285

>  <SMILES>
CC(C)CN1CCC2(COCc3cnc(NCC4CC4)nc32)C1

$$$$
SWF005286
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005286

>  <SMILES>
Cc1cccc(CN2Cc3[nH]nc(COCc4nccs4)c3C2)n1

$$$$
SWF005287
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005287

>  <SMILES>
O=C(NCc1ccncc1)C1=NOC2(CCCN(C(=O)C3(F)CC3)C2)C1

$$$$
SWF005288
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005288

>  <SMILES>
C[C@@H]1CN(C(=O)c2cccn(C)c2=O)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF005289
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005289

>  <SMILES>
O=c1c(=O)n2c(nn1CC1CC1)COC1(CCN(Cc3cccnc3)C1)C2

$$$$
SWF005290
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005290

>  <SMILES>
Cc1ccc(NC(=O)c2ncn3c(C4CCN(CC5CC5)CC4)ccnc23)c(C)c1

$$$$
SWF005291
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005291

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2ncc(C(F)(F)F)[nH]2)N1Cc1ccc(F)cc1

$$$$
SWF005292
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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M  END
>  <HTSID>
SWF005292

>  <SMILES>
O=C1COC2(COCCN(Cc3ccccn3)C2)CN1c1ccccc1

$$$$
SWF005293
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005293

>  <SMILES>
O=C(c1cnn2ccccc12)N1CCC2(CCN(Cc3cccnc3)CC2)CC1

$$$$
SWF005294
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005294

>  <SMILES>
O=C(NC1CCCC1)c1nnc2n1CC1(CC2)CCN(Cc2ccccn2)CC1

$$$$
SWF005295
Actelion Java MolfileCreator 1.0

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M  END
>  <HTSID>
SWF005295

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccccc3F)CC2)CN1Cc1ccncc1

$$$$
SWF005296
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005296

>  <SMILES>
c1cncc(CN2CCC3(C2)CN(Cc2cccnc2)c2cccnc23)c1

$$$$
SWF005297
Actelion Java MolfileCreator 1.0

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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 23 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 10 14  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005297

>  <SMILES>
CN1CCN(CC2COC3(CCCN(C(=O)c4ccc(-n5cccc5)cc4)C3)C2)CC1

$$$$
SWF005298
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005298

>  <SMILES>
Cc1cccc(CN2CCC3(CCc4nnc(C(=O)NC(C)C)n4C3)CC2)n1

$$$$
SWF005299
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 13 10  1  6  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
  6  7  1  0  0  0  0
 11 13  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005299

>  <SMILES>
Cn1cc(CN2CCC3(C2)CN(Cc2ccccn2)c2cccnc23)cn1

$$$$
SWF005300
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.4313   -5.4893   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005300

>  <SMILES>
O=C(c1ccc(F)cc1)N1CCc2onc(COc3cccnc3)c2C1

$$$$
SWF005301
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0926    2.4343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005301

>  <SMILES>
COCC(=O)N1CCC2(COCc3c(C)nc(N4CCOCC4)nc32)C1

$$$$
SWF005302
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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   12.1014   -0.7879   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3051   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.7144    0.5888   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9872   -2.0070   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4859   -1.8495   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3717   -3.0687   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0988   -0.4728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8704   -2.9111   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5975   -0.3153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.4833   -1.5345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.9820   -1.3770   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005302

>  <SMILES>
COCCN1CC2(CCN(C(=O)Nc3ccc(C)cc3)CC2)C2(CCN(C)C2=O)C1

$$$$
SWF005303
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -3.4345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  7  1  1  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005303

>  <SMILES>
O=C1CO[C@@H]2CN(Cc3ccccn3)C[C@H]2N1Cc1ccncc1

$$$$
SWF005304
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3454    1.7454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9280    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005304

>  <SMILES>
O=C(Nc1cccnc1)C1=NOC2(CCCN(C(=O)N3CCCC3)C2)C1

$$$$
SWF005305
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10  9  1  1  0  0  0
 16 19  1  0  0  0  0
 18 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005305

>  <SMILES>
O=C(NCc1ccncc1)C1=NOC2(CCCN(C(=O)CC3CC3)C2)C1

$$$$
SWF005306
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    7.1421   -0.9763   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6683   -0.0957   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.7201    1.6356   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2269   -1.1466   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2942    1.0994   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8946   -4.4642   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9107   -4.2857   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  1  0  0  0  0
 23 27  1  0  0  0  0
 24 28  2  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 25 28  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005306

>  <SMILES>
CN(C)C(=O)N1CCC[C@]2(C(=O)NCC3CC3)CN(c3ncccn3)C[C@@H]2C1

$$$$
SWF005307
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    3.7013    1.4872   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6145    2.6772   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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M  END
>  <HTSID>
SWF005307

>  <SMILES>
CC(=O)CN1CC2(CCN(C(C)=O)CC2)COc2ccccc2S1(=O)=O

$$$$
SWF005308
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005308

>  <SMILES>
Cc1ccccc1CN1C[C@@H]2[C@H](CNC(=O)c3cnccn3)CO[C@@H]2C1

$$$$
SWF005309
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005309

>  <SMILES>
CCN1C(=O)[C@H]2CN(C(C)=O)C[C@H]2C12CCN(C(=O)Nc1cccc(OC)c1)CC2

$$$$
SWF005310
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 23 25  1  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF005310

>  <SMILES>
O=C(COCC1CN(Cc2cccs2)Cc2cncn21)N1CCCC1

$$$$
SWF005311
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005311

>  <SMILES>
CNC(=O)N1CC[C@@H]2Oc3ccccc3S(=O)(=O)N(Cc3cccnc3)[C@H]2CC1

$$$$
SWF005312
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 27 30  1  0  0  0  0
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 14 15  1  0  0  0  0
 25 26  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005312

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(C(=O)C3CCCCC3)C[C@H]1CN(Cc1cnn(C)c1)C2

$$$$
SWF005313
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  6 10  2  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 23 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF005313

>  <SMILES>
CC1c2nc(C(=O)NC3CCC3)cn2CCN1Cc1ccc2c(c1)OCO2

$$$$
SWF005314
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 17 22  1  0  0  0  0
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 22 24  1  0  0  0  0
  4  7  1  0  0  0  0
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 19 20  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005314

>  <SMILES>
Cc1nc[nH]c1C(=O)N1CC2(CC(OCC3CCOCC3)CS2)C1

$$$$
SWF005315
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005315

>  <SMILES>
COc1cccc(NC(=O)N2CCC3(CC2)CN(C(C)=O)CC32CCN(C)C2=O)c1

$$$$
SWF005316
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.4049   -7.8882   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005316

>  <SMILES>
COCCN1CC(COC)C2(CCN(Cc3cccc(F)c3)CC2)C1

$$$$
SWF005317
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.1209   -3.3681   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0190   -4.8952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.7988   -7.6358   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005317

>  <SMILES>
O=C(c1ccnnc1)N1CCOC2(CCN(C(=O)c3ccc(F)cc3)C2)C1

$$$$
SWF005318
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.1224    1.1774   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  2  0  0  0  0
 23 26  2  0  0  0  0
  6  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005318

>  <SMILES>
c1ccc(CN2CCOCC3(CCCN(Cc4cccnc4)C3)C2)nc1

$$$$
SWF005319
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6505   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  6  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
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 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005319

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)c3cnccn3)CC2)c2ccccc21

$$$$
SWF005320
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  6  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 19  1  0  0  0  0
 21 23  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005320

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3ccncc3)CC2)c2ccccc21)N1CCOCC1

$$$$
SWF005321
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005321

>  <SMILES>
O=C(c1ccccn1)N1CCc2nc(N3CCOCC3)nc(NC3CC3)c2C1

$$$$
SWF005322
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005322

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(CC4CC4)CC3)c3ccccc32)CC1

$$$$
SWF005323
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005323

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(C(=O)c4ccccn4)CC3)c3ccccc32)CC1

$$$$
SWF005324
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005324

>  <SMILES>
O=C(Nc1ccc(Cl)cc1)c1nc2c(s1)CCN(C(=O)c1cccnc1)CC2

$$$$
SWF005325
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 11 14  2  0  0  0  0
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 18 19  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005325

>  <SMILES>
CN(C)C(=O)CC1CC2(CCN(C(=O)c3ccnnc3)CC2)Oc2ccccc21

$$$$
SWF005326
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 23 24  1  0  0  0  0
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 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005326

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)CCn1c2nn(Cc2ccccc2)c(=O)c1=O

$$$$
SWF005327
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.1045   -3.0545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005327

>  <SMILES>
O=C(c1cccc(F)c1)N1CCC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF005328
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    4.3001    1.3335   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 28 30  1  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005328

>  <SMILES>
CCN1CCC2(CN(C(C)=O)CC23CCN(C(=O)c2cccc(OC)c2)CC3)C1=O

$$$$
SWF005329
Actelion Java MolfileCreator 1.0

 31 36  0  0  0  0  0  0  0  0999 V2000
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 26 29  2  0  0  0  0
 28 30  1  0  0  0  0
 29 31  1  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
 27 29  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005329

>  <SMILES>
O=C1N(CC2CC2)CCOC12CN(Cc1ccc3c(c1)OCO3)CC2c1cccnc1

$$$$
SWF005330
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF005330

>  <SMILES>
CN(Cc1cccnc1)C1COC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF005331
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005331

>  <SMILES>
O=C(c1cnccn1)N1C[C@H]2C[C@H]3[C@](C1)(CN(Cc1ccccc1)S3(=O)=O)O2

$$$$
SWF005332
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005332

>  <SMILES>
COc1ccc(C(=O)N2CCc3onc(COc4cccnc4)c3C2)cc1

$$$$
SWF005333
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005333

>  <SMILES>
c1cncc(CN2CCCC(c3nc4ccc(N5CCOCC5)cn4n3)C2)c1

$$$$
SWF005334
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005334

>  <SMILES>
O=C(CC1CC2(CCN(CC3CC3)CC2)c2ccccc21)N1CCOCC1

$$$$
SWF005335
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005335

>  <SMILES>
CCN1CCC2(CN(Cc3cccnc3)CC23CCN(Cc2ccccn2)CC3)C1=O

$$$$
SWF005336
Actelion Java MolfileCreator 1.0

 31 34  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005336

>  <SMILES>
CN(C)C(=O)[C@]12CCCN(C(=O)Nc3ccccc3)C[C@H]1CN(Cc1cnn(C)c1)C2

$$$$
SWF005337
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005337

>  <SMILES>
COc1cccc(CN2CCCC3(CCN(Cc4cnn(C)c4)C3)C2)c1

$$$$
SWF005338
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005338

>  <SMILES>
Cn1cccc(C(=O)N2CC3Cc4cnc(N5CCCC5)nc4C3C2)c1=O

$$$$
SWF005339
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 20 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005339

>  <SMILES>
O=C(NC1CC1)c1nnc2n1CC1(CC2)CCN(C(=O)c2ccco2)CC1

$$$$
SWF005340
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
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 13 16  1  1  0  0  0
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 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005340

>  <SMILES>
C[C@@H]1CN(Cc2ccc(F)cc2)C[C@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF005341
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.3596   -6.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 16 20  1  0  0  0  0
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 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  2  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005341

>  <SMILES>
O=C(NCC1CCCO1)C1Cn2ccnc2C2(CCN(Cc3nccs3)CC2)O1

$$$$
SWF005342
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005342

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)CC(OCc1ccccn1)CO2

$$$$
SWF005343
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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  5 10  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005343

>  <SMILES>
CCN1C(=O)[C@H]2CN(C(C)=O)C[C@H]2C12CCN(C(=O)Nc1ccccc1)CC2

$$$$
SWF005344
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.7938   -3.3010   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005344

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(C(=O)c1cc(F)cc(F)c1)C2

$$$$
SWF005345
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
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 13 10  1  6  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 25 26  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005345

>  <SMILES>
O=C(c1ccc(F)cc1)N1CCC2(CC(=O)N(c3ccc(F)cc3)C2)C1

$$$$
SWF005346
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  7 11  1  0  0  0  0
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  8 13  1  0  0  0  0
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 10 16  1  0  0  0  0
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 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 25 27  1  0  0  0  0
 11 17  1  0  0  0  0
 12 13  1  0  0  0  0
 14 16  2  0  0  0  0
 23 25  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005346

>  <SMILES>
Cn1cnc2c1C(C(=O)NCC1CC1)CN(Cc1ccc3c(c1)OCO3)C2

$$$$
SWF005347
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005347

>  <SMILES>
O=C(c1cnccn1)N1CCC2(CCN(Cc3cccc(F)c3)CC2)C1

$$$$
SWF005348
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  6  0  0  0
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 13 17  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005348

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2ccc(F)cc2)C1

$$$$
SWF005349
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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  5  7  1  0  0  0  0
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 16 19  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005349

>  <SMILES>
COc1ccc(CN2C[C@@H]3CN(C(=O)c4ccncc4)C[C@@H]3C2=O)cc1

$$$$
SWF005350
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005350

>  <SMILES>
Cc1ccc(NC(=O)N2CCC3(CC3C(=O)NCc3cccnc3)C2)cc1

$$$$
SWF005351
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005351

>  <SMILES>
O=C(C1CCCCC1)N1CCn2nnc(COCc3cccnc3)c2C1

$$$$
SWF005352
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005352

>  <SMILES>
Cc1ccc(CN2CCOC3(CCN(Cc4cnn(C)c4)CC3)C2)cc1

$$$$
SWF005353
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 21 25  2  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  5  9  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 22 25  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005353

>  <SMILES>
CN1CCC2(CN(c3ncccn3)CC23CCN(C(=O)c2cnccn2)CC3)C1=O

$$$$
SWF005354
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.1962   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
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 18 21  1  6  0  0  0
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 21 24  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005354

>  <SMILES>
CNC(=O)CC1CC2(CCN(C(=O)c3cccnc3)CC2)Oc2ccccc21

$$$$
SWF005355
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   10.0575    0.5861   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF005355

>  <SMILES>
COc1ccc(CN2CCC3(CCN(C(=O)c4cnccn4)CC3)C2)cc1

$$$$
SWF005356
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11 15  2  0  0  0  0
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 16 18  1  0  0  0  0
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 12 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF005356

>  <SMILES>
COc1cccc(CN2CCC3(CC2)CCN(C(=O)c2ccccn2)C3)c1

$$$$
SWF005357
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005357

>  <SMILES>
Cc1ccc(CN2CCOC3(CCN(Cc4ccncc4)CC3)C2)cc1

$$$$
SWF005358
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -1.0685  -10.7827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.4584  -12.1530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005358

>  <SMILES>
O=C(Cc1cccnc1)N1CCC2(CCN(CC3CCCCC3)CC2)C1

$$$$
SWF005359
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005359

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CC1)CN(c1ccccc1)C(=O)CO2

$$$$
SWF005360
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005360

>  <SMILES>
O=C(Nc1cccnc1)C1CN(C(=O)c2ccccc2)CC12CCOCC2

$$$$
SWF005361
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
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 12 18  1  0  0  0  0
 13 19  2  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
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 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 10 12  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  END
>  <HTSID>
SWF005361

>  <SMILES>
CCCN(C)C(=O)c1ncn2c1CN(CC(=O)NC)S(=O)(=O)c1ccccc1-2

$$$$
SWF005362
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  2  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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 12 13  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005362

>  <SMILES>
O=C(Nc1ccccc1)C1CN(Cc2cccnc2)CC12CCOCC2

$$$$
SWF005363
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    9.6602    0.5354   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.2807    8.1593   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
 10  5  1  6  0  0  0
  6 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005363

>  <SMILES>
COc1ccc(-c2nnc3n(c2=O)CCC32CCN(C(=O)c3cnccn3)C2)cc1

$$$$
SWF005364
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6913    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.2894    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.9904    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.5885    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   14.2894    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  2  0  0  0  0
  6  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005364

>  <SMILES>
COc1ccc(CN2CCC3(CC2)CCN(Cc2ccccn2)CC3)cc1

$$$$
SWF005365
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
   13.2155   -5.4589   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 25 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005365

>  <SMILES>
CCN1CCC2(CN(C(=O)N(C)C)CC23CCN(Cc2ccc(F)cc2)CC3)C1=O

$$$$
SWF005366
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
    6.3862    0.1631   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.4135   -8.6234   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  0  0  0  0
 10 17  1  0  0  0  0
 11 18  2  0  0  0  0
 11 19  1  0  0  0  0
 13 20  2  0  0  0  0
 16 21  1  0  0  0  0
 17 22  1  0  0  0  0
 19 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 12 15  1  0  0  0  0
 14 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005366

>  <SMILES>
CCC(=O)N1CCC2(CC1)COc1ccccc1S(=O)(=O)N(CC(=O)NC)C2

$$$$
SWF005367
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005367

>  <SMILES>
c1ccc(CN2CCC3OCCCC3(COc3cccnc3)C2)nc1

$$$$
SWF005368
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005368

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)CC(NC(=O)N(C)C)C3)o1

$$$$
SWF005369
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005369

>  <SMILES>
O=C(C1CCOCC1)N1CC2(CC(OCC3CC3)CS2)C1

$$$$
SWF005370
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  0  0  0  0
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 22 23  1  0  0  0  0
  7 10  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005370

>  <SMILES>
COc1ccc(C(=O)N2CCCC3(CCCC(=O)N3C)C2)cc1

$$$$
SWF005371
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7987    1.3841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005371

>  <SMILES>
Cc1ccc(CN2CCCC3(CCN(Cc4ccco4)C3)C2)o1

$$$$
SWF005372
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    8.9221   -4.0808   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4303   -3.9240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0374   -0.9427   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  1  0  0  0
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 17 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005372

>  <SMILES>
C=CCO[C@@H]1CN(C(=O)Cc2ccccn2)[C@@H]2CCCO[C@@H]21

$$$$
SWF005373
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1113   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6113   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1224   -2.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2903    0.0633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2208   -0.4540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9512    0.7241   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9010    0.2791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6313    1.4572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  6  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005373

>  <SMILES>
CN(C)CCN1CCOCC2(CCN(Cc3ccco3)CC2)C1

$$$$
SWF005374
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    3.4899   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    3.4899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005374

>  <SMILES>
CCOc1ccc(CCC(=O)N2C[C@@H]3C[C@@H](C)O[C@@H]3C2)cc1

$$$$
SWF005375
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.2473   -4.4975   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1458   -3.5780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2432   -4.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1207   -3.3555   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6073   -2.9201   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4658   -3.4330   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9012   -5.1610   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8009   -4.0885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4154   -2.3999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5061   -5.0441   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7758   -3.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
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  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  2  0  0  0  0
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 12  9  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005375

>  <SMILES>
Cc1ccc(N2CC3(COCCN(Cc4ccncc4)C3)OCC2=O)s1

$$$$
SWF005376
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  7  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005376

>  <SMILES>
Cc1ccc(CN2CCC3(CCN(Cc4ccccn4)CC3)CC2)o1

$$$$
SWF005377
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005377

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(OCC3CC3)CS2)C1

$$$$
SWF005378
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.7160    0.1817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005378

>  <SMILES>
Cc1cncc(C(=O)N2CC3CCC2C3Oc2ccccn2)c1

$$$$
SWF005379
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005379

>  <SMILES>
O=C1COC2(COCCN(Cc3cccs3)C2)CN1c1ccc(F)cc1

$$$$
SWF005380
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005380

>  <SMILES>
Cn1ccnc1CN1C[C@@H]2[C@H](NC(=O)CC3CCOCC3)c3ccccc3[C@@H]2C1

$$$$
SWF005381
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005381

>  <SMILES>
CCCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccc(C)c(O)c1)C2

$$$$
SWF005382
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005382

>  <SMILES>
O=C(CC1CC1)N1CCc2ncnc(-c3ccncc3)c2CC1

$$$$
SWF005383
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005383

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF005384
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 15  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005384

>  <SMILES>
O=C(N1CCCC1)N1CCCC2(COCCN(c3cccnc3)C2)C1

$$$$
SWF005385
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
   11.4667   -0.9168   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.4630    0.1980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9265    1.6245   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.9228    2.7393   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4556    2.4274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    3.5421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9154    4.9687   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9847    3.2302   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  1  0  0  0
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 20 21  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005385

>  <SMILES>
CCO[C@@H]1CC[C@H]2[C@H]1OCCN2C(=O)c1ccc(Cl)cc1

$$$$
SWF005386
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005386

>  <SMILES>
Cc1ccc(CN2CCC3(CC2)C(=O)Nc2ccccc23)s1

$$$$
SWF005387
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.0059   -2.5409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5793   -2.0773   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005387

>  <SMILES>
CC(=O)N1[C@H](CN(C)C)C[C@@H]2CN(Cc3ccccn3)CC[C@@H]21

$$$$
SWF005388
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.8366   -1.4945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF005388

>  <SMILES>
COc1ccc(NC2CSC3(C2)CN(C(=O)c2ccns2)C3)cc1

$$$$
SWF005389
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF005389

>  <SMILES>
Cn1ccc(-c2nc(C(=O)NCc3ccc(F)cc3)c3ccccn23)c1

$$$$
SWF005390
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  2  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005390

>  <SMILES>
CN1CCN(c2ncnc3c2CCN(C2CCOCC2)CC3)CC1

$$$$
SWF005391
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
   10.0500    3.5421   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 11  1  6  0  0  0
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 26 28  2  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005391

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3cccc(F)c3F)CC[C@H]21)NCc1ccon1

$$$$
SWF005392
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005392

>  <SMILES>
O=C([C@H]1CCC[C@]12CCN(Cc1ccccn1)C2)N1CCOCC1

$$$$
SWF005393
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 25 27  3  0  0  0  0
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF005393

>  <SMILES>
N#Cc1cccc(N2CC3(CCN(C(=O)c4cccc(Cl)n4)C3)CC2=O)c1

$$$$
SWF005394
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005394

>  <SMILES>
CCN1C(=O)CCC12CCCN(C(=O)c1cnc(C)cn1)C2

$$$$
SWF005395
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 10 11  2  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005395

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)c2occc2C)C3)n1

$$$$
SWF005396
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 10 11  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005396

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(C(=O)c2ccco2)C3)n1

$$$$
SWF005397
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 10 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005397

>  <SMILES>
Cn1cc(C(=O)N2C[C@H]3CCC[C@@]3(COCC3CC3)C2)cn1

$$$$
SWF005398
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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 14 13  1  1  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005398

>  <SMILES>
Cc1nc(C(=O)N2CC[C@H]3[C@H](CO[C@H]3CNC(=O)c3ccncc3)C2)cs1

$$$$
SWF005399
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005399

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@H]3O[C@@H](C(=O)NCC4CC4)C[C@H]32)n1

$$$$
SWF005400
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.6760   -2.3876   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005400

>  <SMILES>
O=C(c1cscn1)N1CCC2(C1)CN(C(=O)C1(F)CC1)C2

$$$$
SWF005401
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    2.5933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    3.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    3.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9073    3.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  6  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005401

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@@H]3OCCN(Cc4ccncc4)[C@H]3C2)n1

$$$$
SWF005402
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6980   -1.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9909   -2.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228   -2.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8228   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005402

>  <SMILES>
CN(C)C1CC2(CCN(C(=O)/C=C/c3cccs3)CC2)C1

$$$$
SWF005403
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.7383   -3.1927   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2019   -1.7662   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005403

>  <SMILES>
Fc1ccc(CN2CCC(n3cnc4nccnc43)CC2)cc1

$$$$
SWF005404
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8712    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2532    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  6  0  0  0
  8 13  1  0  0  0  0
 11 14  1  6  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005404

>  <SMILES>
O=C(CCc1ccc[nH]1)N1C[C@H]2OCC[C@H]2[C@H](C(=O)N2CCCC2)C1

$$$$
SWF005405
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  2  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005405

>  <SMILES>
Cc1noc(CC(=O)N2CCCC3(CCN(c4cncnc4)CC3)C2)n1

$$$$
SWF005406
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.0190   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 13 16  1  0  0  0  0
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 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005406

>  <SMILES>
CCOCCC1CCOC2(C1)CN(C(=O)c1ccccn1)C2

$$$$
SWF005407
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    7.3115    0.2011   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005407

>  <SMILES>
Cc1csc(C[C@H]2OC[C@H]3CN(C(=O)Cc4ccco4)CC[C@H]32)n1

$$$$
SWF005408
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005408

>  <SMILES>
O=C(N1CCC2(CCN(Cc3cccnc3)CC2)CC1)C1(F)CC1

$$$$
SWF005409
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005409

>  <SMILES>
CC1CC(C(=O)N2CCCC3(CCN(CCN(C)C)C3=O)C2)C1

$$$$
SWF005410
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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    1.4150    3.4054   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005410

>  <SMILES>
O=C1CCC2(CCCN(C(=O)C3(F)CC3)CC2)N1CC1CC1

$$$$
SWF005411
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.1046   -4.3745   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.1249   -4.5750   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005411

>  <SMILES>
O=C(N1CCCn2nnc(CN3CCCCC3)c2C1)C1(F)CC1

$$$$
SWF005412
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005412

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF005413
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.2869   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005413

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(CC(OCc3ccncc3)CCO2)C1

$$$$
SWF005414
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  1  0  0  0  0
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M  END
>  <HTSID>
SWF005414

>  <SMILES>
COCCN1CC(COC)C2(CCN(C(=O)c3ccc(C)cc3)CC2)C1

$$$$
SWF005415
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 23 26  2  0  0  0  0
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 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005415

>  <SMILES>
Cc1ccccc1CN1CC2(CC(OCC(=O)N3CCCC3)CCO2)C1

$$$$
SWF005416
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    9.8850    2.2071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0190    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1529    0.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
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 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005416

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3cccc(F)c3)C2)CN1CC1CC1

$$$$
SWF005417
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487   -2.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808   -3.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 13 14  1  0  0  0  0
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 18 20  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005417

>  <SMILES>
CS(=O)(=O)N1CCO[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]21

$$$$
SWF005418
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    6.1665    3.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    4.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6665    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6720    2.4781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0733    1.6691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1665    5.1808   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1665    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665    5.1808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  2  1  6  0  0  0
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  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005418

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@@H]2CCN(C(=O)Cc3ccccc3)C[C@H]2O1

$$$$
SWF005419
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9572   10.3718   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.6454    8.9045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2188    8.4410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7601    7.9008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0931    6.9738   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4482    6.4336   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0216    5.9701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7098    4.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8245    3.4992   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5126    2.0320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6273    1.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7629    0.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005419

>  <SMILES>
COCC1CN(C)CC12CCN(Cc1ccc(F)cc1)CC2

$$$$
SWF005420
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   -0.0000    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 17  2  0  0  0  0
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 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 12 17  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005420

>  <SMILES>
COCC12CCCOC1CCN(C(=O)c1ncnc(C)c1C)C2

$$$$
SWF005421
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.6886    3.4067   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4888    2.8069   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3694    1.8141   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4083    3.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4498    1.4210   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1695    1.2142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2084    2.6001   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6497    2.0209   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3304    0.4282   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  6 10  2  0  0  0  0
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 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  7 10  1  0  0  0  0
 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005421

>  <SMILES>
COCCN1CCC2(COCCN(C(=O)c3ccncc3F)C2)C1

$$$$
SWF005422
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7670   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3603   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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  7 12  1  0  0  0  0
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 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005422

>  <SMILES>
COCCN1CC(COC)C2(CCN(C(=O)c3cccn3C)CC2)C1

$$$$
SWF005423
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.9211    3.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  3  0  0  0  0
 18 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005423

>  <SMILES>
COC[C@@H]1CC[C@H]2[C@H](CCN2C(=O)c2cccc(C#N)c2)O1

$$$$
SWF005424
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   12.2294   -3.3107   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.9304   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9304   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005424

>  <SMILES>
Cc1cccc(COC2CCOC3(C2)CN(Cc2ccccc2F)C3)n1

$$$$
SWF005425
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.9304    2.5607   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   12.2294    1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005425

>  <SMILES>
CS(=O)(=O)NC1CC2(CCN(C(=O)Cc3ccccc3)CC2)C1

$$$$
SWF005426
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 18 20  2  0  0  0  0
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 19 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005426

>  <SMILES>
COCC1CN(C)CC12CCN(Cc1cccc(C)n1)CC2

$$$$
SWF005427
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9535   -3.6160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -1.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0413   -1.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005427

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(=O)N(C)C3)cn1

$$$$
SWF005428
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.9128    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1348    1.2340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0859    0.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9269    2.2121   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9759    2.5211   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6701    2.8813   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  1  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005428

>  <SMILES>
Cc1nc(COCC[C@H]2CO[C@H]3CN(C(=O)N(C)C)C[C@@H]23)cs1

$$$$
SWF005429
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116    2.5933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    3.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1808    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1808    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1808    3.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1808    5.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6808    2.4704   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6808    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6808    2.4704   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 27 30  2  0  0  0  0
 29 31  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005429

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCCN(C(=O)c5ccccn5)C4)nn3c2)c1

$$$$
SWF005430
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.3642    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8301    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3902   -2.9781   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9889   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3956   -3.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005430

>  <SMILES>
O=C([C@@H]1CN(C(=O)C2(F)CC2)C[C@H]2OCC[C@H]21)N1CCCC1

$$$$
SWF005431
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.9244    2.5677   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2582    3.5103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0014    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2059    4.5089   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2596    3.4580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9524    3.1502   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7935    1.8630   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2073    4.4566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5366    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6345    0.5759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3287    0.2158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005431

>  <SMILES>
COCCN1C(=O)CCC12CCN(C(=O)C1(F)CCC1)CC2

$$$$
SWF005432
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2090   -4.4672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7008   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3109   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4508   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7008   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9508   -5.9231   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8325   -7.1366   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8325   -4.7095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2590   -6.6731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2590   -5.1731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 13 11  1  1  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005432

>  <SMILES>
O=C([C@H]1C[C@@H]2CCN(S(=O)(=O)C3CC3)C[C@H]2O1)N1CCCC1

$$$$
SWF005433
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9931    0.3236   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4518    0.8638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3049    1.7909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7636    2.3310   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1902    2.7945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5021    4.2618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3874    5.2655   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6992    6.7327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.1258    7.1962   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5845    7.7364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8461    5.8056   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4377    8.6634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1579    7.2729   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  4  7  1  0  0  0  0
 10 12  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005433

>  <SMILES>
COCCC1CCOC12CCN(Cc1ccccc1OC)CC2

$$$$
SWF005434
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8109    1.3799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6859    3.3479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.2820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1418    2.1230   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 14 19  1  0  0  0  0
 14 20  2  0  0  0  0
 15 21  2  0  0  0  0
 17 22  2  0  0  0  0
 19 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  9 10  1  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 23 24  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005434

>  <SMILES>
O=C(NCc1cccnc1)c1nc(-c2cn(-c3ccccn3)cn2)n2ccccc12

$$$$
SWF005435
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    3.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 13 19  2  0  0  0  0
 14 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 17 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 10 13  1  0  0  0  0
 18 23  1  0  0  0  0
 19 22  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005435

>  <SMILES>
CC(=O)N1CCC2(CC1)OC(C(=O)NCc1ccccc1)Cn1ccnc12

$$$$
SWF005436
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1852   -3.1097   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9352   -1.8106   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 14 17  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005436

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCOCC1c1nccc(NC2CCC2)n1

$$$$
SWF005437
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  6 10  1  0  0  0  0
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 18 19  1  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005437

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CC1)CC(NS(=O)(=O)C1CC1)CCO2

$$$$
SWF005438
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005438

>  <SMILES>
O=C(c1ccco1)N1CCC2(CCOCC2COc2ccccn2)CC1

$$$$
SWF005439
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    6.6840   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  8 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF005439

>  <SMILES>
N#Cc1ccc(OC[C@@H]2CO[C@@H]3CN(C(=O)C4CC(O)C4)C[C@H]23)cc1

$$$$
SWF005440
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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 21 23  1  0  0  0  0
  5  7  2  0  0  0  0
 13 16  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005440

>  <SMILES>
CN1C(=O)C2(CCN(C(=O)c3ccco3)CC2)c2ccccc21

$$$$
SWF005441
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005441

>  <SMILES>
O=C(C1CC1)N1CCOC2CCC1C2Oc1ncccc1F

$$$$
SWF005442
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF005442

>  <SMILES>
COCC(=O)NC[C@]12COC[C@H]1CN(Cc1cccs1)C2

$$$$
SWF005443
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    9.2059   -2.1409   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005443

>  <SMILES>
CCC(CC)CN1CCC(Nc2cccc(F)c2)(C(=O)NC)C1

$$$$
SWF005444
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005444

>  <SMILES>
Fc1ccc(CN2CCn3c(COCc4cccnc4)nnc3C2)cc1F

$$$$
SWF005445
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 11 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF005445

>  <SMILES>
CCCc1onc(C)c1C(=O)N1CC2(C1)CN(CC1CC1)C(C(=O)NC)CO2

$$$$
SWF005446
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.6308    0.0234   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005446

>  <SMILES>
Cn1ccc(NC(=O)C2(n3cccn3)CCN(Cc3ccccc3)CC2)n1

$$$$
SWF005447
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005447

>  <SMILES>
O=C(CC1CN(CC2CCOCC2)Cc2ccnn21)N1CC(F)(F)C1

$$$$
SWF005448
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005448

>  <SMILES>
CNC(=O)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2ccc(OC)cc2)O1

$$$$
SWF005449
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005449

>  <SMILES>
O=C(CC1(O)CCC1)N1CCc2ncnc(N3CCOCC3)c2CC1

$$$$
SWF005450
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF005450

>  <SMILES>
O=C1NC2(CCN(C(=O)C3CC3)CC2)c2nc(-c3cccs3)sc21

$$$$
SWF005451
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005451

>  <SMILES>
COC1(CC(=O)N2CCC3(CC2)CC(=O)N(CC2CC2)C3)CCC1

$$$$
SWF005452
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
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 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 21 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005452

>  <SMILES>
O=C1c2cccnc2C2(CCN(Cc3ccccn3)CC2)N1Cc1ccccc1

$$$$
SWF005453
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005453

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)c3ncn(C)n3)CC2)C1=O

$$$$
SWF005454
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005454

>  <SMILES>
CN(C)C1CC2(CCN(C(=O)CCS(C)(=O)=O)CC2)C1

$$$$
SWF005455
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005455

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2cscn2)CC1

$$$$
SWF005456
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  1  0  0  0  0
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M  END
>  <HTSID>
SWF005456

>  <SMILES>
O=C1CCCN1CCC1CN(Cc2cccc3[nH]ccc23)Cc2ccnn21

$$$$
SWF005457
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  8  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  2  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005457

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF005458
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005458

>  <SMILES>
O=C(N1CCOC2(CCN(Cc3ccncc3)CC2)C1)C1(F)CC1

$$$$
SWF005459
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8956   -3.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.9889   -2.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6921   -3.1397   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4522   -5.0365   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  1  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005459

>  <SMILES>
COc1cc(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)on1

$$$$
SWF005460
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.8669    1.2340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1978    1.9771   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1237    0.5649   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6100    1.9031   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1456    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2283   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005460

>  <SMILES>
CCc1ccc(C(=O)N2CC[C@H]3CN(S(C)(=O)=O)C[C@H]32)cn1

$$$$
SWF005461
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.1962    0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.3923   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  8 10  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005461

>  <SMILES>
O=C(c1csnn1)N1CCOC2(CCN(Cc3ccncc3)CC2)C1

$$$$
SWF005462
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.9385   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5486   -5.1375   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9221   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.6402   -6.7429   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 22  3  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005462

>  <SMILES>
COCCN1CC2(CCN(C(=O)C3(C#N)CCCC3)CC2)CC1=O

$$$$
SWF005463
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005463

>  <SMILES>
C[C@H]1C[C@H]2CN(C(=O)c3cccc4c3OCCO4)CC[C@H]2O1

$$$$
SWF005464
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005464

>  <SMILES>
CCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2ccco2)CC1

$$$$
SWF005465
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005465

>  <SMILES>
COCCN1C(=O)CCC12CCN(C(=O)C1CC(C)C1)CC2

$$$$
SWF005466
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005466

>  <SMILES>
Cc1ccc(N2CCN(CC3CC3)C3(CCN(C(=O)C4CC4C)CC3)C2=O)cn1

$$$$
SWF005467
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005467

>  <SMILES>
O=C(c1cccnc1)N1CCC(c2nc3ccc(-c4cccs4)cn3n2)CC1

$$$$
SWF005468
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005468

>  <SMILES>
O=C(NCCC1CCOC12CN(C(=O)C1CCC1)C2)c1cccnc1

$$$$
SWF005469
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005469

>  <SMILES>
O=C(c1cscn1)N1CCCC2(CCN(C(=O)C3(F)CC3)CC2)C1

$$$$
SWF005470
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3090    0.3056   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
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M  END
>  <HTSID>
SWF005470

>  <SMILES>
C=CCN1CCOCC2(C1)CN(C(=O)C1(F)CCC1)CCO2

$$$$
SWF005471
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005471

>  <SMILES>
Cn1ccc(C(=O)N2C[C@@H]3[C@H](C2)n2cccc2C(=O)N3Cc2cccnc2)n1

$$$$
SWF005472
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF005472

>  <SMILES>
O=C(N1CCCC2(COCCN(c3cnccn3)C2)C1)C1(F)CC1

$$$$
SWF005473
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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   -6.4726   -2.1977   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1417   -1.4546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1198   -1.6625   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 28 29  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
 21 22  2  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005473

>  <SMILES>
Cc1ccc(-c2cnc3n2CCN(C)C32CCN(Cc3ccc(C)o3)CC2)cc1

$$$$
SWF005474
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0935   -4.6240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1565   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4834   -3.2537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0382   -4.7095   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005474

>  <SMILES>
Cc1c(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)nc2ccccn12

$$$$
SWF005475
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5295   -3.0088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005475

>  <SMILES>
c1cncc(O[C@H]2CO[C@@]3(CCCN(Cc4ccoc4)C3)C2)c1

$$$$
SWF005476
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005476

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)C3(F)CCC3)C[C@H]12)c1ccncc1

$$$$
SWF005477
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 20 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005477

>  <SMILES>
Cc1cccc(CO[C@H]2CO[C@@]3(CCCN(Cc4cnn(C)c4)C3)C2)n1

$$$$
SWF005478
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  2  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005478

>  <SMILES>
c1ccc(-c2ccc3nc(C4CCN(Cc5ccoc5)CC4)nn3c2)cc1

$$$$
SWF005479
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
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 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
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 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005479

>  <SMILES>
O=C(Nc1cccc(F)c1)c1cc(-c2cnc(-c3ccccc3)nc2)cn1CC1CC1

$$$$
SWF005480
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF005480

>  <SMILES>
O=C(NCCO)c1ccn(-c2ccc3ccc(-c4ccc(F)cc4)cn23)n1

$$$$
SWF005481
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 12  1  0  0  0  0
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 14 12  1  6  0  0  0
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 16 18  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF005481

>  <SMILES>
Cn1c(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)C2CC2)C3)cccc1=O

$$$$
SWF005482
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
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M  END
>  <HTSID>
SWF005482

>  <SMILES>
O=C(C1CC=CC1)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF005483
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.1104    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005483

>  <SMILES>
COc1cc(C(=O)N2CC[C@H](O)[C@@H]2Cc2ccccc2)on1

$$$$
SWF005484
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 14 18  1  6  0  0  0
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 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005484

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@@H]3OCCN(CC4CC4)[C@H]3C2)n1

$$$$
SWF005485
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 25 27  2  0  0  0  0
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 10 13  1  0  0  0  0
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 18 22  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005485

>  <SMILES>
CN1Cc2nnc(-c3ccccc3)n2C2(CCN(C(=O)c3ccco3)CC2)C1

$$$$
SWF005486
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF005486

>  <SMILES>
COCC1CC2(CCN(Cc3ccc(C)o3)CC2)CN1C(C)C

$$$$
SWF005487
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF005487

>  <SMILES>
O=S(=O)(C1CC1)N1CCC(F)(F)C2(CCN(c3ccccc3)C2)C1

$$$$
SWF005488
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 15  1  1  0  0  0
 13 16  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005488

>  <SMILES>
O=C(C1=CCCC1)N1Cc2ccnn2C(CCOCC2CCOCC2)C1

$$$$
SWF005489
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
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 13 16  1  0  0  0  0
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 16 18  1  1  0  0  0
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 24 26  2  0  0  0  0
  7 11  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005489

>  <SMILES>
CN1CCC(COCc2ccncc2)CC12CN(S(=O)(=O)C(F)(F)F)C2

$$$$
SWF005490
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.7510   -2.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005490

>  <SMILES>
CN(C)C(=O)COC1CCOC2(C1)CN(c1ncc(F)cn1)C2

$$$$
SWF005491
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005491

>  <SMILES>
O=C(NC[C@H]1CO[C@@H]2CN(Cc3cccnc3)C[C@H]12)c1ccncc1

$$$$
SWF005492
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4343   -5.2956   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005492

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)C3(F)CC3)C[C@H]12)c1cccnc1

$$$$
SWF005493
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005493

>  <SMILES>
C[C@H]1CN(C)C[C@@]12COCCN(C(=O)Cc1ccccc1)C2

$$$$
SWF005494
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005494

>  <SMILES>
CC(C)C(=O)N1C[C@@H]2[C@@H](CNC(=O)c3cccnc3)CO[C@@H]2C1

$$$$
SWF005495
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005495

>  <SMILES>
COCC12CCCOC1CCN(C(=O)C1(C#N)CCCC1)C2

$$$$
SWF005496
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005496

>  <SMILES>
CN(C)CCN1CC2CN(C(=O)Cc3cccc(F)c3)CC2C1=O

$$$$
SWF005497
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005497

>  <SMILES>
O=C1CCCN1C[C@@H]1CCC[C@]2(CCN(S(=O)(=O)C3CC3)C2)O1

$$$$
SWF005498
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005498

>  <SMILES>
CC1CC1C(=O)N1Cc2cccn2CC(Oc2ccccn2)C1

$$$$
SWF005499
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005499

>  <SMILES>
c1ccc(-c2ccc3nc(C4CCN(Cc5ccncc5)CC4)nn3c2)cc1

$$$$
SWF005500
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  1  0  0  0
 12 14  1  1  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005500

>  <SMILES>
CO[C@@H]1CCN(C2CCOCC2)C[C@@H]1Cc1cccc(C)c1

$$$$
SWF005501
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6727   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
 11 14  1  0  0  0  0
 15 16  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005501

>  <SMILES>
O=C(CCF)N1Cc2cccn2CC(Oc2ccccn2)C1

$$$$
SWF005502
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    9.7465    2.4885   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0774    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6601    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0829    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5556    1.0873   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  1  0  0  0
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 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005502

>  <SMILES>
CN(C)C(=O)CO[C@H]1CO[C@@]2(CCCN(Cc3cccs3)C2)C1

$$$$
SWF005503
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  1  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005503

>  <SMILES>
c1cncc(O[C@@H]2CO[C@@]3(CCCN(Cc4ccsc4)C3)C2)c1

$$$$
SWF005504
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.4891    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0256    3.9790   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0219    2.8643   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3323    1.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9563    2.8643   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7026    0.4506   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8834    1.4489   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7063    1.5653   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  2  0  0  0  0
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005504

>  <SMILES>
CCOCC(=O)N1CC2(C1)C(COc1ncccn1)CCS2(=O)=O

$$$$
SWF005505
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
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 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005505

>  <SMILES>
O=C1CC2(COCCN(Cc3cccc(F)c3)C2)CN1Cc1ccccc1

$$$$
SWF005506
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.9393   -0.8309   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  5  1  0  0  0  0
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 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005506

>  <SMILES>
Cc1cccc(CN2CCC3(CC2)CN(C)Cc2nnc(C)n23)c1

$$$$
SWF005507
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  6  0  0  0
 13 14  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005507

>  <SMILES>
CS(=O)(=O)NC[C@@H]1CO[C@@H]2CN(Cc3ccsc3)C[C@H]12

$$$$
SWF005508
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005508

>  <SMILES>
CC(C)CC(=O)N1CC2(CC(Oc3ccccn3)CCO2)C1

$$$$
SWF005509
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4047   -8.0129   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005509

>  <SMILES>
O=C(NCc1cccs1)[C@@H]1CO[C@@H]2CN(C(=O)c3cccs3)C[C@@H]21

$$$$
SWF005510
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    7.8417   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  2  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005510

>  <SMILES>
Cc1csc(CN2Cc3ccnn3C(C(=O)NCC3CCOCC3)C2)n1

$$$$
SWF005511
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -7.3713   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -6.6213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -5.1213   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -7.3713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5559   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8221   -7.8759   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5721   -9.1750   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005511

>  <SMILES>
O=C(c1cocn1)N1CC2(CC(CCOc3ccccn3)CCO2)C1

$$$$
SWF005512
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005512

>  <SMILES>
CCN1CC[C@]2(CN(C(=O)c3cncc(C)c3)C[C@H]2C)C1=O

$$$$
SWF005513
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  6  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005513

>  <SMILES>
Cn1c(C(=O)N2CC[C@@H]3OCCN(CC4CC4)[C@H]3C2)cccc1=O

$$$$
SWF005514
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   11.9651    7.5605   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3550    6.1902   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4569    7.4037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4697    5.1865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8878    5.8783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7688    5.9365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4243    4.4517   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9570    4.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4280    3.3370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4935    2.7133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005514

>  <SMILES>
CCNC(=O)c1nnc2n1CC1(CC2)CCN(Cc2cccs2)CC1

$$$$
SWF005515
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    7.5392   -2.0193   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 10  1  1  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005515

>  <SMILES>
Cn1ccc(C(=O)N2C[C@H]3Cn4c(-c5ccsc5)cnc4[C@H]3C2)n1

$$$$
SWF005516
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005516

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3ccccn3)C2)CN1CC1CC1

$$$$
SWF005517
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005517

>  <SMILES>
O=C(NC1CC1)C1=NOC2(CCN(C(=O)Cc3ccccn3)CC2)C1

$$$$
SWF005518
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 15 20  2  0  0  0  0
 16 21  2  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005518

>  <SMILES>
O=C(c1cocn1)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF005519
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 13 18  1  0  0  0  0
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 14 20  2  0  0  0  0
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 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  9 10  1  0  0  0  0
 16 21  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005519

>  <SMILES>
Cc1nc(-c2nc(C(=O)NCC3CCCO3)c3ccccn23)cn1Cc1ccccc1

$$$$
SWF005520
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005520

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(C(=O)NC2CC2)=NO3)C1

$$$$
SWF005521
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 23 24  2  0  0  0  0
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 24 26  1  0  0  0  0
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 26 28  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005521

>  <SMILES>
c1ccc(Nc2ccc3nc(C4CCN(Cc5ccoc5)CC4)nn3c2)cc1

$$$$
SWF005522
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 12  8  1  1  0  0  0
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 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 11  2  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005522

>  <SMILES>
Cn1cccc1C(=O)NCCC1CCOC12CN(C(=O)C1CCC1)C2

$$$$
SWF005523
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
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 14 15  1  0  0  0  0
 16 17  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005523

>  <SMILES>
c1ccn(Cc2nnc3n2CCCN(Cc2ccncc2)C3)c1

$$$$
SWF005524
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005524

>  <SMILES>
c1ccc(CO[C@H]2CN(Cc3ccoc3)[C@@H]3CCCO[C@H]23)nc1

$$$$
SWF005525
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005525

>  <SMILES>
Cn1cccc1C(=O)N1CCC(C(=O)N2CCC2)(n2cccn2)CC1

$$$$
SWF005526
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.7054    0.4169   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.7050    0.3907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6386    0.7491   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467    1.3243   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8861   -1.3318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2802    1.6827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005526

>  <SMILES>
O=C1CC2(CCN(C(=O)C3(F)CCC3)CC2)CN1CC1CC1

$$$$
SWF005527
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5889    1.9659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2961    0.7412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
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  8 11  2  0  0  0  0
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 10 14  2  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005527

>  <SMILES>
Cc1cccc(C(=O)N2CC3(C2)CN(C)C(C(=O)NC2CCCC2)CO3)c1

$$$$
SWF005528
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7096   -5.3566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.5231   -7.1837   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  6  8  1  0  0  0  0
 14 16  2  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005528

>  <SMILES>
O=C(Nc1cccc(F)c1)c1cc(-c2cnc(-c3cccnc3)nc2)cn1CC1CC1

$$$$
SWF005529
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5408    3.6515   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4225    4.8650   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3206    6.3921   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8124    6.2353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0087    7.8593   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3078    8.6093   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  6  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  7  8  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005529

>  <SMILES>
Cc1ccc(-c2cnc3n2CC2(CCN(C(=O)C4CC4)C2)OC3)cc1

$$$$
SWF005530
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 14  9  1  1  0  0  0
 10 15  1  1  0  0  0
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 10 14  1  0  0  0  0
 17 22  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005530

>  <SMILES>
O=C(NCc1ccccn1)[C@@H]1C[C@H]2OCC[C@H]2N(C(=O)C2CCOC2)C1

$$$$
SWF005531
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  2  0  0  0  0
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 27 29  1  0  0  0  0
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 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005531

>  <SMILES>
Cc1ccc(C(=O)N2CCC(c3nc4ccc(N5CCOCC5)cn4n3)C2)cc1

$$$$
SWF005532
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 25 27  1  0  0  0  0
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 29 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
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 18 23  1  0  0  0  0
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 21 24  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF005532

>  <SMILES>
COc1ccc(CNC(=O)C2Cn3ccnc3C3(CCN(Cc4cnn(C)c4)CC3)O2)cc1

$$$$
SWF005533
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  8  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005533

>  <SMILES>
CN1CC2(CCC1=O)CCN(C(=O)Cc1ccccn1)CC2

$$$$
SWF005534
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    0.1595    3.4206   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 10 13  1  0  0  0  0
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005534

>  <SMILES>
CCCNC(=O)c1nnc2n1CC1(CCN(C(=O)c3ccco3)CC1)COC2

$$$$
SWF005535
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    2.2216   -4.2565   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5525   -4.9997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 24 26  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005535

>  <SMILES>
CS(=O)(=O)NC[C@H]1OC[C@@H]2CCN(C(=O)CCc3ccccc3F)C[C@@H]21

$$$$
SWF005536
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005536

>  <SMILES>
O=C(NC[C@H]1CO[C@@H]2CN(C(=O)CC3CC3)C[C@H]12)c1cccnc1

$$$$
SWF005537
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005537

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)CC3CC3)C[C@H]12)c1cccnc1

$$$$
SWF005538
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
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 10 14  2  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
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 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
  7  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 26  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005538

>  <SMILES>
CN1CC2(CCN(C(=O)C3CC3)CC2)c2nc(N3CCCCC3)ncc2C1=O

$$$$
SWF005539
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.8339   -3.8614   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005539

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)CNc1c(F)cccc12

$$$$
SWF005540
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9867    2.8555   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0022    4.8321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
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 14 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 12 18  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF005540

>  <SMILES>
CCOC1CN(C(=O)c2cccc(O)c2)Cc2cccn2C1

$$$$
SWF005541
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8484   -1.4929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0850   -3.9199   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -2.8632   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005541

>  <SMILES>
O=C(NC1CC1)C1=NOC2(CCN(C(=O)c3ccccc3)CC2)C1

$$$$
SWF005542
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    0.7321    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7321    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005542

>  <SMILES>
FC(F)(F)c1ccnc(N2CCC3(COCc4c3n[nH]c4-c3ccccc3)C2)n1

$$$$
SWF005543
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.5163   -6.3168   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005543

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CC1=O

$$$$
SWF005544
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 12  1  0  0  0  0
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 11 16  1  0  0  0  0
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 10 15  1  0  0  0  0
 13 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005544

>  <SMILES>
COc1cnccc1C(=O)N1CC[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF005545
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005545

>  <SMILES>
O=C(c1ccccn1)N1CCCC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF005546
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.8545    0.3295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4478   -0.5841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 11  2  0  0  0  0
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 10 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005546

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)c1ncnc(C)c1C)C2

$$$$
SWF005547
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005547

>  <SMILES>
CCN1CC2(CCC1=O)CCN(C(=O)c1csc(C)n1)CC2

$$$$
SWF005548
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF005548

>  <SMILES>
Cn1cc(CN2CC3(C2)OCCC3COc2ccccn2)cn1

$$$$
SWF005549
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    7.4262   -4.3213   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 19 21  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF005549

>  <SMILES>
CN(C)C(=O)NC[C@@H]1CO[C@@H]2CN(Cc3ccsc3)C[C@H]12

$$$$
SWF005550
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005550

>  <SMILES>
O=c1ccc2c(n1CC1CC1)CCC(NCc1cccs1)C2

$$$$
SWF005551
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005551

>  <SMILES>
Fc1cccc(CN2C[C@H]3CN(Cc4ccncc4)C[C@H]3C2)c1

$$$$
SWF005552
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
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 10 15  1  0  0  0  0
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 15 18  1  0  0  0  0
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 18 21  2  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005552

>  <SMILES>
Cc1ccccc1S(=O)(=O)N1C[C@@H]2CNC(=O)[C@@H](C)[C@@H]2C1

$$$$
SWF005553
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005553

>  <SMILES>
Fc1cccnc1OC1CCOC2(C1)CN(Cc1ccco1)C2

$$$$
SWF005554
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005554

>  <SMILES>
c1cnc(N2CC3(CC(OCC4CCCC4)CCO3)C2)nc1

$$$$
SWF005555
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005555

>  <SMILES>
COCc1ccc(C(=O)N2C[C@@H]3CN(S(C)(=O)=O)CCO[C@@H]3C2)cc1

$$$$
SWF005556
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005556

>  <SMILES>
O=C(N1CCC2(CC1)CC(Nc1ncccn1)CCO2)C1(F)CC1

$$$$
SWF005557
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 18 20  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005557

>  <SMILES>
CNC(=O)CC1CN(Cc2ccc3ccccc3n2)Cc2ccnn21

$$$$
SWF005558
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005558

>  <SMILES>
CC1CC(C(=O)N2CCC3(CCC(=O)N(CC4CC4)C3)CC2)C1

$$$$
SWF005559
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.2518   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 13 16  2  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005559

>  <SMILES>
CS(=O)(=O)N1CCC2(COc3ccc(-c4cncnc4)cc32)C1

$$$$
SWF005560
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.1457   -7.1999   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005560

>  <SMILES>
O=C1CC2(CCN(C(=O)C3CC(O)C3)CC2)CN1Cc1cccnc1

$$$$
SWF005561
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.2759   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005561

>  <SMILES>
O=C(c1ccncc1)N1CC2CN(c3ccccc3)C(=O)C2C1

$$$$
SWF005562
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   12.1669   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005562

>  <SMILES>
Cn1c2c(ccc1=O)CCN(C(=O)NCc1cccnc1)CC2

$$$$
SWF005563
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 25 26  2  0  0  0  0
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 28 30  2  0  0  0  0
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 16 20  1  0  0  0  0
 18 19  1  0  0  0  0
 22 24  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005563

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC2(C1)CN(Cc1cccnc1)c1cccnc12

$$$$
SWF005564
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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 14 16  1  6  0  0  0
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M  END
>  <HTSID>
SWF005564

>  <SMILES>
CC1CC1C(=O)N1C[C@@H]2[C@@H](CNC(=O)c3cccn3C)CO[C@@H]2C1

$$$$
SWF005565
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.8790    4.3612   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005565

>  <SMILES>
C=CCN1CCC2(CCN(Cc3ccc(F)cc3)CC2)C1=O

$$$$
SWF005566
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005566

>  <SMILES>
c1ccc(CN2CCc3nc(N4CCCC4)nc(NC4CC4)c3C2)cc1

$$$$
SWF005567
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF005567

>  <SMILES>
Cc1nc(C(=O)N2CCC3(C2)CN(C)c2cccnc23)cs1

$$$$
SWF005568
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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 12  9  1  6  0  0  0
 10 13  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005568

>  <SMILES>
Cc1occc1C(=O)N1CCC2(CCn3c(-c4cccs4)cnc32)C1

$$$$
SWF005569
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  8  1  0  0  0  0
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 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005569

>  <SMILES>
O=C(C1CC1)N1CCC2(C1)Cn1c(-c3ccccc3)cnc1CO2

$$$$
SWF005570
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005570

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3C(C(=O)N4CCOCC4)=NO[C@@H]3C2)cs1

$$$$
SWF005571
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 17 21  2  0  0  0  0
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 22 24  1  0  0  0  0
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 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  9 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 21  1  0  0  0  0
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 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005571

>  <SMILES>
CN1CCN(C(=O)CC2CC3(CCN(Cc4ccccn4)CC3)c3ccccc32)CC1

$$$$
SWF005572
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005572

>  <SMILES>
CC(C)C(=O)N1C[C@@H]2[C@H](CNC(=O)c3cccnc3)CO[C@@H]2C1

$$$$
SWF005573
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 16 20  1  0  0  0  0
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 25 27  2  0  0  0  0
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 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005573

>  <SMILES>
CC(=O)N1Cc2sc(C(C)C)nc2C2(CCN(Cc3cccnc3)CC2)C1

$$$$
SWF005574
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 12 11  1  1  0  0  0
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 13 16  1  0  0  0  0
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 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005574

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CC[C@H]2CN(Cc3cccnc3)C[C@H]21

$$$$
SWF005575
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
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 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005575

>  <SMILES>
O=C(NC1CC1)C1=NOC2(CCN(C(=O)CC3(O)CCC3)CC2)C1

$$$$
SWF005576
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
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 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005576

>  <SMILES>
O=C(NC[C@H]1CO[C@@H]2CN(C(=O)C3CCC3)C[C@H]12)c1ccncc1

$$$$
SWF005577
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -5.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 23 24  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005577

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CCC(=O)N(CC)C3)CC2)cn1

$$$$
SWF005578
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.0749    4.2169   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3264    2.7693   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2399    3.1760   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005578

>  <SMILES>
CC(=O)c1cc(C(=O)N2CC3(CCN(CC(C)C)C3)C2)n[nH]1

$$$$
SWF005579
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2731   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9641   -3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 17 20  1  0  0  0  0
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 18 22  1  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 20 22  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005579

>  <SMILES>
CC(C)CNC(=O)c1nc(-c2ccnn2-c2ccccc2)n2ccncc12

$$$$
SWF005580
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 10  1  6  0  0  0
 11 12  1  0  0  0  0
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 12 15  1  6  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 22  1  0  0  0  0
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 22 24  1  0  0  0  0
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 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005580

>  <SMILES>
Cc1nc(C(=O)NC[C@@H]2CO[C@@H]3CN(C(=O)C4CCC4)C[C@H]23)cs1

$$$$
SWF005581
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    4.6435    3.8404   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 10 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005581

>  <SMILES>
CCN(C)C(=O)c1cnn2c1CN(C(=O)CN(C)C(C)C)CCC2

$$$$
SWF005582
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005582

>  <SMILES>
CS(=O)(=O)N[C@H]1C[C@@]2(CCN(C(=O)C3(C#N)CCCC3)C2)C1

$$$$
SWF005583
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  1  0  0  0  0
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M  END
>  <HTSID>
SWF005583

>  <SMILES>
c1ccc(OC2CSC3(C2)CN(Cc2ccoc2)C3)nc1

$$$$
SWF005584
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.2615    4.1013   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005584

>  <SMILES>
CN(C)CCN1CCCC12CCN(C(=O)c1cccs1)CC2

$$$$
SWF005585
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005585

>  <SMILES>
Cc1cccc(CN2CCC3(CCN(c4ncccn4)CC3)C2=O)c1

$$$$
SWF005586
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005586

>  <SMILES>
O=C1CCCCN1CC1CCC2(CN(Cc3ccccn3)C2)OC1

$$$$
SWF005587
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 30 32  2  0  0  0  0
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 15 17  2  0  0  0  0
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 25 26  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF005587

>  <SMILES>
Cc1ccc(NC(=O)c2cc(-c3cnc(-c4cccnc4)nc3)cn2CC2CC2)cc1F

$$$$
SWF005588
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  6  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005588

>  <SMILES>
Cc1csc(C[C@H]2OC[C@H]3CN(C(=O)c4ocnc4C)CC[C@H]32)n1

$$$$
SWF005589
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
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 10  8  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  7  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005589

>  <SMILES>
Fc1cccnc1OCC1CCOC12CN(Cc1ccco1)C2

$$$$
SWF005590
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.3207   -6.7201   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 18  2  0  0  0  0
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 15 20  1  0  0  0  0
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 17 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  9 11  1  0  0  0  0
 18 23  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005590

>  <SMILES>
COCCC1CCOC12CCN(C(=O)COc1ccccc1OC)CC2

$$$$
SWF005591
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 15  1  6  0  0  0
 13 16  1  0  0  0  0
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 26 27  1  0  0  0  0
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 11 12  2  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005591

>  <SMILES>
COCC1CN(C(=O)c2ccco2)CC12CCN(Cc1cc(C)on1)CC2

$$$$
SWF005592
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.4036   -1.2006   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005592

>  <SMILES>
CCCC(=O)N1CC2(C1)C(COc1ncccn1)CCS2(=O)=O

$$$$
SWF005593
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005593

>  <SMILES>
CC1CC1C(=O)N1C[C@@H]2[C@H](CNC(=O)c3cccn3C)CO[C@@H]2C1

$$$$
SWF005594
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487   -2.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005594

>  <SMILES>
CC1CC(C(=O)N2C[C@@H]3OCCN(S(C)(=O)=O)[C@@H]3C2)C1

$$$$
SWF005595
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005595

>  <SMILES>
COCC(=O)N1Cc2cccn2CC(Oc2ccccn2)C1

$$$$
SWF005596
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005596

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCCN(C(=O)C5CC5)C4)nn3c2)c1

$$$$
SWF005597
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005597

>  <SMILES>
O=C(C1Cn2ccnc2C2(CCN(CC3CC3)CC2)O1)N1CCCC1

$$$$
SWF005598
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005598

>  <SMILES>
c1ccc(COC2COC3(CCN(C4CCC4)CC3)C2)nc1

$$$$
SWF005599
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.6167    1.5774   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.4005    2.8563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6351    4.3379   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9189    3.0910   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7739    1.7996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5537   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005599

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)C3(F)CCC3)C2)C1=O

$$$$
SWF005600
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    5.1400    1.1522   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005600

>  <SMILES>
CN(C)C(=O)N1CCCC1c1nc(C(=O)NCC(C)(C)C)c2ccccn12

$$$$
SWF005601
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 13 18  1  0  0  0  0
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 16 22  1  0  0  0  0
 17 23  2  0  0  0  0
 21 24  2  0  0  0  0
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 19 20  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005601

>  <SMILES>
COCC1CCn2nccc2CN1C(=O)COc1ccccc1C

$$$$
SWF005602
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF005602

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)C3CCC3)C[C@H]12)c1cccnc1

$$$$
SWF005603
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF005603

>  <SMILES>
CCS(=O)(=O)N1C[C@@H]2[C@@H](CNC(=O)c3csc(C)n3)CO[C@@H]2C1

$$$$
SWF005604
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005604

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3[C@H](C2)n2cccc2C(=O)N3Cc2ccccn2)cs1

$$$$
SWF005605
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
   11.2792   -1.6106   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0656   -3.7125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005605

>  <SMILES>
O=C(N1CCC2(CC1)CCN(c1ccsc1)C2=O)C1(F)CC1

$$$$
SWF005606
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  1  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005606

>  <SMILES>
N#CC1(C(=O)N2C[C@@H]3OCCN(CC4CC4)[C@@H]3C2)CCCC1

$$$$
SWF005607
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.2847   -3.9169   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 20 22  1  0  0  0  0
 10 12  1  1  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005607

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3CN(S(C)(=O)=O)CCO[C@@H]3C2)o1

$$$$
SWF005608
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 14 17  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005608

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)CC(=O)N(Cc2cccnc2)C3)n1

$$$$
SWF005609
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.6808    2.9345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8147    3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 10 12  1  0  0  0  0
 13 14  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005609

>  <SMILES>
CC1c2nc(C(=O)NC3CCCC3)cn2CCN1S(C)(=O)=O

$$$$
SWF005610
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    5.1962    4.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1962    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 12 13  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005610

>  <SMILES>
CCOCC1COCCC12CCN(C(=O)CS(C)(=O)=O)CC2

$$$$
SWF005611
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005611

>  <SMILES>
Cc1ccc(CN2CCC3(CCC(C(=O)N(C)C)O3)CC2)o1

$$$$
SWF005612
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   12.9401    4.0031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.5699    4.6132   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005612

>  <SMILES>
O=C(N[C@H]1C[C@]2(CCN(C(=O)C3CC(F)(F)C3)C2)C1)C1CC1

$$$$
SWF005613
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   12.9272   -1.9978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.0455   -0.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.6556    0.5861   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9436   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7739    1.7996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.5024    4.3835   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 18 21  1  6  0  0  0
 21 22  1  0  0  0  0
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 23 24  1  0  0  0  0
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 14 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF005613

>  <SMILES>
CCOCC1CCC2(CCN(C(=O)Cc3ccccc3)CC2)N1C

$$$$
SWF005614
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005614

>  <SMILES>
Cc1ccsc1CN1CCC2(CC1)c1ccccc1N(C)S2(=O)=O

$$$$
SWF005615
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005615

>  <SMILES>
O=C(c1cnccn1)N1C[C@H]2CN(Cc3cccc(F)c3)C[C@H]2C1

$$$$
SWF005616
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005616

>  <SMILES>
O=C(NC[C@H]1CO[C@@H]2CN(C(=O)CC3CC3)C[C@H]12)c1cscn1

$$$$
SWF005617
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005617

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)C3(C#N)CCCC3)C[C@H]2C)C1=O

$$$$
SWF005618
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 27 30  2  0  0  0  0
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 25 26  2  0  0  0  0
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M  END
>  <HTSID>
SWF005618

>  <SMILES>
C=CCN1c2cccnc2-n2cccc2C12CCN(C(=O)c1cccc(C)c1O)C2

$$$$
SWF005619
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005619

>  <SMILES>
Cn1cnc(C2CN(Cc3ccsc3)CC23CCN(CC2CC2)C3=O)c1

$$$$
SWF005620
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005620

>  <SMILES>
N#CCCNC(=O)c1nc(-c2cn(Cc3ccccc3)cn2)n2ccccc12

$$$$
SWF005621
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005621

>  <SMILES>
c1coc(CN2CCN(CCn3cccn3)c3ncccc3C2)c1

$$$$
SWF005622
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005622

>  <SMILES>
C=C(C)CN1c2cccnc2-n2cccc2C12CCN(C(=O)c1ccccn1)C2

$$$$
SWF005623
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005623

>  <SMILES>
Cc1ccc(C(=O)N2CCOC3(COCCN(c4cnccn4)C3)C2)o1

$$$$
SWF005624
Actelion Java MolfileCreator 1.0

 31 36  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 29 31  1  0  0  0  0
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 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <HTSID>
SWF005624

>  <SMILES>
O=C1N(CC2CC2)Cc2ccccc2CC12CCN(c1ncc3ccccc3n1)CC2

$$$$
SWF005625
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005625

>  <SMILES>
Cc1cccc(C(=O)N2CCn3cc(C(=O)NCc4cnc(C)cn4)nc3C2C)c1

$$$$
SWF005626
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF005626

>  <SMILES>
COC[C@@]12CCO[C@@H]1CCN(C(=O)Cc1cccc(F)c1)C2

$$$$
SWF005627
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
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    1.3062    1.7719   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 18 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005627

>  <SMILES>
CCC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)NCCOC)C1

$$$$
SWF005628
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
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   10.0656   -3.7125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005628

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCC2(CC1)CCN(c1ccsc1)C2=O

$$$$
SWF005629
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -7.2049   -6.2904   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.7049   -6.2904   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005629

>  <SMILES>
Cn1cc(C(=O)N[C@H]2C[C@]3(CCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3)C2)cn1

$$$$
SWF005630
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0524   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2942   -8.1204   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005630

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)c4cc[nH]n4)CC3)CC2=O)cc1

$$$$
SWF005631
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2163    0.4514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8330    0.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6717    1.2900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
 17 22  1  0  0  0  0
 18 23  2  0  0  0  0
 19 24  1  0  0  0  0
 20 25  2  0  0  0  0
 22 26  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005631

>  <SMILES>
COc1ccccc1CN1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF005632
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.4354   -8.6002   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8515   -8.3286   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005632

>  <SMILES>
CC1c2nc(CC(=O)N(C)C)cn2CCN1Cc1cnn(C(C)C)c1

$$$$
SWF005633
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0136   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8057   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9670   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005633

>  <SMILES>
O=C(C1=CCCC1)N1CC2(C1)OCCC2COc1cccnc1

$$$$
SWF005634
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005634

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(C(=O)c3cc[nH]n3)CC2)C1

$$$$
SWF005635
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    6.4209   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6119   -2.7949   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005635

>  <SMILES>
Cc1ccsc1CN1CC2(CC(OCc3ccccn3)CCO2)C1

$$$$
SWF005636
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005636

>  <SMILES>
O=C1CC2(CCN(C(=O)C3(F)CC3)CC2)CN1Cc1cccc(F)c1

$$$$
SWF005637
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3898   -1.8566   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2420   -0.4502   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0191   -1.0795   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005637

>  <SMILES>
CC(C)C(=O)NC1COC2(CCN(C(=O)CC3(O)CCC3)CC2)C1

$$$$
SWF005638
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   14.5648   -1.2064   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   13.0730   -1.0496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.4629    0.3207   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.9711    0.4775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6995   -2.1063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0894   -0.7360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3610    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF005638

>  <SMILES>
Cc1noc(CC(=O)N2CCC3(CC2)CC(=O)N(Cc2cccc(F)c2)C3)n1

$$$$
SWF005639
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9385   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005639

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cc[nH]n3)CC2)CC1=O

$$$$
SWF005640
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.0981    6.0029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
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 10 14  1  6  0  0  0
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  9 10  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005640

>  <SMILES>
CC(=O)N1CC[C@H]2C[C@H](C(=O)NCC3CCOCC3)O[C@@H]2C1

$$$$
SWF005641
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  1  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005641

>  <SMILES>
Cn1cc(CN2CCO[C@H]3[C@@H](OCc4ccncc4)CC[C@@H]32)cn1

$$$$
SWF005642
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005642

>  <SMILES>
O=C(CC1(O)CCC1)N1CCC2(CCN(Cc3cccnc3)CC2)CC1

$$$$
SWF005643
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    7.5711   -0.8907   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
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 28 30  2  0  0  0  0
  9 12  1  0  0  0  0
 14 18  1  0  0  0  0
 19 20  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005643

>  <SMILES>
COc1cccc(CC(=O)N2CCC3(CC2)CC(N(C)Cc2ccccc2)CO3)c1

$$$$
SWF005644
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    6.9128    5.5326   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 12 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF005644

>  <SMILES>
O=C(C1CC1)N1CCCC(c2nc3ccc(-c4cccc(F)c4)cn3n2)C1

$$$$
SWF005645
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   10.7510   -0.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005645

>  <SMILES>
COCCN1CC2(CCC1=O)CCN(C(=O)C1CC(F)C1)CC2

$$$$
SWF005646
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.5191   -3.5032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF005646

>  <SMILES>
COCCNC(=O)C1CCc2c(C(=O)NC3CC3)ncn2C1

$$$$
SWF005647
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.4425    3.9494   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 22 25  1  0  0  0  0
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 12 15  1  0  0  0  0
 16 17  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005647

>  <SMILES>
Cc1cccc(COC2CN(S(=O)(=O)C3CC3)Cc3ccnn3C2)n1

$$$$
SWF005648
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005648

>  <SMILES>
c1cnc(NC[C@H]2CO[C@@H]3CN(Cc4ccncc4)C[C@H]23)nc1

$$$$
SWF005649
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.8185   -3.6502   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005649

>  <SMILES>
CC(=O)N1CCC2(CC1)OCCC2CCOCc1cccc(C)n1

$$$$
SWF005650
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.2869    1.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005650

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)N(C)C)C2)CN1CC1CC1

$$$$
SWF005651
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    8.9405    0.6445   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4405    0.6445   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005651

>  <SMILES>
O=C(Cc1ccc(F)cn1)N1CC[C@H]2[C@H]1CCN2S(=O)(=O)C1CC1

$$$$
SWF005652
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.9304    2.5607   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005652

>  <SMILES>
CS(=O)(=O)NC1CC2(CCN(C(=O)CC3(O)CCC3)CC2)C1

$$$$
SWF005653
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005653

>  <SMILES>
Cc1ccc(CN2CCO[C@H]3CN(Cc4ccsc4)C[C@H]32)o1

$$$$
SWF005654
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    7.7942   -7.3713   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005654

>  <SMILES>
COCCC1CCOC2(C1)CN(C(=O)COc1ccccc1C)C2

$$$$
SWF005655
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005655

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCC2OCCN(c3cccnc3)C2CC1

$$$$
SWF005656
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 19 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005656

>  <SMILES>
CN1CCCC2(C1)CN(C(=O)Cc1ccc(F)cn1)CCO2

$$$$
SWF005657
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
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 12 17  3  0  0  0  0
 13 18  1  0  0  0  0
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 18 23  2  0  0  0  0
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 22 26  1  0  0  0  0
 22 27  1  0  0  0  0
 24 28  2  0  0  0  0
 10 11  2  0  0  0  0
 16 20  1  0  0  0  0
 19 23  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005657

>  <SMILES>
CC(C)n1c2ccccc2c2c1cc(C(=O)NCCC#N)n2-c1ncccn1

$$$$
SWF005658
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.3101   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    0.5537    1.3100   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3101    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
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 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005658

>  <SMILES>
O=C(N1CCC1)C1(n2cccn2)CCN(S(=O)(=O)c2ccccc2)CC1

$$$$
SWF005659
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005659

>  <SMILES>
O=C(NCCO)c1cc(-c2cnc(-c3ccccc3)nc2)cn1CC1CC1

$$$$
SWF005660
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.8428   -7.2579   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8465   -6.1432   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3100   -7.5697   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0260   -2.1375   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  2  0  0  0  0
M  END
>  <HTSID>
SWF005660

>  <SMILES>
CN(C)C(=O)C1=NO[C@@H]2CN(C(=O)C3CC(F)(F)C3)C[C@H]12

$$$$
SWF005661
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    9.0203    3.8763   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5285    4.0331   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7785    5.3321   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.3113    5.0203   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005661

>  <SMILES>
CC1=N[C@@]2(CC[C@@H]3CN(CC(C)C)C[C@@H]32)C(=O)N1CC1CC1

$$$$
SWF005662
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005662

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)/C=C/c3cccs3)C2)CN1C

$$$$
SWF005663
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF005663

>  <SMILES>
CC(C)NC(=O)C1CCc2c(C(=O)Nc3ccccc3)ncn2C1

$$$$
SWF005664
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005664

>  <SMILES>
COCC1CC2(CCN(C(=O)CCF)CC2)CN1C(C)C

$$$$
SWF005665
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005665

>  <SMILES>
O=C(Cc1ccsc1)N1CCC(C(=O)N2CCC2)(n2cccn2)CC1

$$$$
SWF005666
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005666

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)Cc3ccsc3)C2)CN1C

$$$$
SWF005667
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005667

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)C4(F)CC4)C[C@H]32)cs1

$$$$
SWF005668
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.8461   -2.8752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1770   -2.1321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3461   -3.7413   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3680   -3.5334   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0360   -0.3752   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  7 10  1  0  0  0  0
 11  8  1  6  0  0  0
 10 12  1  6  0  0  0
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 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005668

>  <SMILES>
O=C1[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]2CN1c1ccsc1

$$$$
SWF005669
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  6  9  1  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
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 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005669

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCc2ncnc(-c3cncnc3)c2C1

$$$$
SWF005670
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
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 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005670

>  <SMILES>
Cn1ccc(N2CCC3(CCN(C(=O)C4CC(F)C4)CC3)C2=O)n1

$$$$
SWF005671
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
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  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005671

>  <SMILES>
O=C(Cn1ccccc1=O)N1CCC2(CC1)CCN(c1ncccn1)C2

$$$$
SWF005672
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005672

>  <SMILES>
O=C(NCc1ccccn1)[C@H]1C[C@@H]2CCN(c3ncccn3)C[C@H]2O1

$$$$
SWF005673
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005673

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCCN(C(=O)c5ccco5)C4)nn3c2)c1

$$$$
SWF005674
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005674

>  <SMILES>
C=CCN1CCOC2CCN(C(=O)c3ccc(C)nc3)CCC21

$$$$
SWF005675
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005675

>  <SMILES>
Cc1nc(C(=O)N2CC3(CC(OCC4CCOCC4)CCO3)C2)cs1

$$$$
SWF005676
Actelion Java MolfileCreator 1.0

 19 21  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005676

>  <SMILES>
Cc1nc(C(=O)N2C[C@@H]3CN(S(C)(=O)=O)C[C@@H]32)cs1

$$$$
SWF005677
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005677

>  <SMILES>
CC(=O)N1CCC2(C1)CN(c1ccsc1)C(=O)CN2C(C)=O

$$$$
SWF005678
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4303   -5.4240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005678

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(=O)N(C)C2

$$$$
SWF005679
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    3.8374    0.0950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3855    1.4913   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
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 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
 10 12  1  1  0  0  0
 14 19  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005679

>  <SMILES>
Cc1nc(CN2CC3(CCN(c4ncccn4)C3)Oc3ccccc3S2(=O)=O)cs1

$$$$
SWF005680
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
    6.9128    5.5326   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4128    4.6665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  2  0  0  0  0
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 17 18  1  0  0  0  0
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 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 27 30  1  0  0  0  0
  6  8  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
 28 30  2  0  0  0  0
M  END
>  <HTSID>
SWF005680

>  <SMILES>
Cn1nccc1C(=O)N1CCCC(c2nc3ccc(-c4cccc(F)c4)cn3n2)C1

$$$$
SWF005681
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    7.2198   -4.8199   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7465    0.0342   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 12 11  1  1  0  0  0
 11 13  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF005681

>  <SMILES>
O=C(c1cc(F)ncc1F)N1C[C@H](OCc2ccccn2)[C@H]2OCCC[C@H]21

$$$$
SWF005682
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005682

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccnnc2)CC1

$$$$
SWF005683
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.3120   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  7 13  1  0  0  0  0
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  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005683

>  <SMILES>
CC(=O)N1CCC(C(=O)Nc2ccccc2)(n2cccn2)CC1

$$$$
SWF005684
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  2  0  0  0  0
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  5  8  2  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005684

>  <SMILES>
Cc1ccsc1C(=O)N1CCC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF005685
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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 14 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF005685

>  <SMILES>
Cn1cc(CN2Cc3ncn(CC4CC4)c3C(COCC3CC3)C2)cn1

$$$$
SWF005686
Actelion Java MolfileCreator 1.0

 33 37  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 29 31  1  0  0  0  0
 30 32  1  0  0  0  0
 31 33  1  0  0  0  0
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 18 23  1  0  0  0  0
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 21 24  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF005686

>  <SMILES>
COc1ccc(CNC(=O)C2Cn3ccnc3C3(CCN(CC4CCOCC4)CC3)O2)cc1

$$$$
SWF005687
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3897   -2.2480   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.6097   -0.2731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005687

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@]2(CCN(C(=O)CC3(O)CCC3)C2)C1

$$$$
SWF005688
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0314   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005688

>  <SMILES>
CCC1COC2(CCN(C(=O)COc3cc(F)ccc3F)C2)C1

$$$$
SWF005689
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005689

>  <SMILES>
CN(C)CC(=O)N1CCC(Nc2ccn(C)n2)(C(=O)N2CCCC2)CC1

$$$$
SWF005690
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  2  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 13  1  0  0  0  0
 14 15  2  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005690

>  <SMILES>
Cc1noc(CC(=O)N2CCc3ncnc(-c4ccncc4)c3C2)n1

$$$$
SWF005691
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.7475    1.0155   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
  8 10  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005691

>  <SMILES>
CN1CC2(CCN(C(=O)c3cn(C)nc3C(F)(F)F)CC2)CC1=O

$$$$
SWF005692
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005692

>  <SMILES>
O=C(c1ncccn1)N1CC2(C1)OCCC2CCOc1cccnc1

$$$$
SWF005693
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005693

>  <SMILES>
O=C(c1ccccn1)N1CCC(c2nc3ccc(-c4ccccc4)cn3n2)CC1

$$$$
SWF005694
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005694

>  <SMILES>
CS(=O)(=O)NCC1CCC2(CN(Cc3cccnc3)C2)OC1

$$$$
SWF005695
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005695

>  <SMILES>
COCCN1CC(COC)C2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF005696
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005696

>  <SMILES>
CC(C)CCN1CC[C@@H]2[C@@H](CO[C@H]2CC(=O)NCC(F)(F)F)C1

$$$$
SWF005697
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF005697

>  <SMILES>
Cn1cnc(C(=O)N2C[C@@H]3OCCN(Cc4cccnc4)[C@@H]3C2)n1

$$$$
SWF005698
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 12 10  1  1  0  0  0
 13 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005698

>  <SMILES>
CN1C[C@@]23CN(C(=O)c4cc(C5CC5)on4)C[C@@H](C[C@@H]2S1(=O)=O)O3

$$$$
SWF005699
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005699

>  <SMILES>
CN1CCN(C(=O)[C@H]2C[C@@H]3CN(S(=O)(=O)C4CC4)C[C@H]2O3)CC1

$$$$
SWF005700
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    8.4556    2.4274   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 14 15  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005700

>  <SMILES>
O=C(CC1=CCCCC1)N1CCO[C@H]2[C@@H](OCC3CC3)CC[C@@H]21

$$$$
SWF005701
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 21 24  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005701

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(C(=O)C3(C#N)CCCC3)CC2)C1

$$$$
SWF005702
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 13 19  1  0  0  0  0
 14 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  5  7  1  0  0  0  0
 15 17  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005702

>  <SMILES>
Cc1noc(C)c1CN1CC2(COCCN(Cc3ccccc3)C2)CC1=O

$$$$
SWF005703
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    0.9977    5.3696   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2158    4.4879   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6424    4.9515   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7477    3.0613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6294    1.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0193    0.4775   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1212    2.0046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1249    0.8899   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8712    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2080   -1.0037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  2  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 18 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005703

>  <SMILES>
CCNC(=O)NC1c2ncnn2CCC12CCN(C(=O)c1csc(C)n1)C2

$$$$
SWF005704
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3433    1.2364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6490    3.3734   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2018    1.7493   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4897    5.1881   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 15 21  1  0  0  0  0
 16 22  2  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 11  1  0  0  0  0
 17 22  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005704

>  <SMILES>
CN1Cc2cccnc2-n2ncc(C(=O)NCc3ccccc3)c2C1

$$$$
SWF005705
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -9.2942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.7615    0.4381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  -10.9182   -1.0537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005705

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1CCC2(CC1)CN(Cc1nccs1)CCO2

$$$$
SWF005706
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -5.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005706

>  <SMILES>
O=C(Cc1ccc(F)cc1)N1CC2(CCC(CN3CCOCC3)CO2)C1

$$$$
SWF005707
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 17  1  0  0  0  0
 11 18  1  0  0  0  0
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 13 20  1  1  0  0  0
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 19 24  1  0  0  0  0
 20 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005707

>  <SMILES>
O=C(Cc1coc2ccccc12)N[C@@H]1c2ccccc2[C@@H]2CNC[C@H]12

$$$$
SWF005708
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005708

>  <SMILES>
CS(=O)(=O)CCC(=O)N1CC[C@]2(C1)C[C@@H](NC(=O)C1CC1)C2

$$$$
SWF005709
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5142    0.2829   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4315    1.4854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 21 24  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005709

>  <SMILES>
Cc1cccc(CN2CCC3(CC(=O)N(c4cnn(C)c4)C3)C2)n1

$$$$
SWF005710
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  2  0  0  0  0
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 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005710

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CCC2(CC1)CNC(=O)CO2

$$$$
SWF005711
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 17 19  1  1  0  0  0
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 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005711

>  <SMILES>
CN(C)C1CCOC2(CCN(C(=O)c3csnn3)CC2)C1

$$$$
SWF005712
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4352   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0470   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9863   -2.1989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7342   -4.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0333   -7.8107   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 24  2  0  0  0  0
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 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005712

>  <SMILES>
Cc1cccc(CN2CC3(CC(Oc4cncc(C)n4)CCO3)C2)n1

$$$$
SWF005713
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9721   -1.2546   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6727   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9875   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6080    0.8256   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005713

>  <SMILES>
O=c1[nH]c(-c2ccccc2)nc2c1OCCN(Cc1ccsc1)C2

$$$$
SWF005714
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  6  0  0  0
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 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005714

>  <SMILES>
COCC1CC2(CCN(C(=O)c3cncc(C)c3)CC2)CO1

$$$$
SWF005715
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.8283    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6603   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005715

>  <SMILES>
COCCNC(=O)[C@@H]1CN(C(=O)C2(F)CC2)C[C@H]2OCC[C@H]21

$$$$
SWF005716
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 23 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005716

>  <SMILES>
CN1CCN(C(=O)[C@H]2C[C@@H]3CN(Cc4ccsc4)C[C@@H]3N2C)CC1

$$$$
SWF005717
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    7.4128    4.6665   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9128    3.8005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005717

>  <SMILES>
Cc1cccc(CN2CCCC(c3nc4ccc(-c5cccnc5)cn4n3)C2)c1

$$$$
SWF005718
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 17 20  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005718

>  <SMILES>
COCC1CC2(CCN(C(=O)c3nn(C)c4ccccc34)CC2)CO1

$$$$
SWF005719
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.0025   -3.4373   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005719

>  <SMILES>
CN(C)C(=O)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF005720
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.8399   -1.5168   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.5308   -0.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5527   -0.3578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2000    0.1774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    0.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8910    1.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  7  1  0  0  0  0
  9 12  1  0  0  0  0
 15 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005720

>  <SMILES>
CCN1CC2(CCN(C(=O)Cc3ccccn3)CC2)c2cc(F)ccc21

$$$$
SWF005721
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
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 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005721

>  <SMILES>
CS(=O)(=O)NC1CC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF005722
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.7942   -7.3713   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005722

>  <SMILES>
O=C(c1ccoc1)N1CC2(CC(CCOc3ncccn3)CCO2)C1

$$$$
SWF005723
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.3953   -2.2452   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4204   -2.4677   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -1.7347   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1257   -3.4233   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0350   -0.7791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005723

>  <SMILES>
C=CCN1CCOCC2(CCN(C(=O)C3CC(O)C3)CC2)C1

$$$$
SWF005724
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  1  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  1  0  0  0
  7 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
 22 25  1  0  0  0  0
 22 26  1  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 24  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005724

>  <SMILES>
CC(C)n1nccc1[C@@H]1CNC[C@]12CCCN(Cc1ccccc1)C2=O

$$$$
SWF005725
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    9.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 15 13  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005725

>  <SMILES>
CCc1ccc(C(=O)N2CCC(C3CCCCN3C)CC2)cn1

$$$$
SWF005726
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    8.6603    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF005726

>  <SMILES>
CCN1CC2(CCC1=O)CCN(C(=O)CN(C)C(C)C)CC2

$$$$
SWF005727
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  6  0  0  0
 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
  9 13  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005727

>  <SMILES>
CCN1CCO[C@H]2CCN(C(=O)Cc3ccc(C)cc3)C[C@@H]21

$$$$
SWF005728
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.1140   -6.0381   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.3709   -5.3690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5788   -4.3909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4198   -5.6780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8356   -3.7217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5298   -4.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6767   -5.0089   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8846   -4.0307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.1037   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6513   -2.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0686   -2.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0468   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005728

>  <SMILES>
O=C(NC[C@H]1CO[C@@H]2CN(Cc3ccccc3F)C[C@H]12)c1cnccn1

$$$$
SWF005729
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    8.6603   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 16  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005729

>  <SMILES>
c1cc(COCC2CN(CC3CCOCC3)Cc3cncn32)ccn1

$$$$
SWF005730
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  6  0  0  0
 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005730

>  <SMILES>
c1csc(CN2CC[C@@H]3OCCN(Cc4ccncc4)[C@H]3CC2)c1

$$$$
SWF005731
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.3202   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.3202   -4.0536   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6192   -3.3036   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8202   -2.5537   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.0702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3202    0.0444   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 10 15  2  0  0  0  0
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 13 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 25 27  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005731

>  <SMILES>
CC1c2nc(C(=O)NCC3CCC3)cn2CCN1S(=O)(=O)c1cccnc1

$$$$
SWF005732
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.2582    3.5103   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0014    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005732

>  <SMILES>
CN(C)CCN1CCCC12CCN(C(=O)c1ccnn1C)CC2

$$$$
SWF005733
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005733

>  <SMILES>
Cc1noc(C2CCC3(CCN(C(=O)c4cnccn4)CC3)O2)n1

$$$$
SWF005734
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  7 10  1  0  0  0  0
  8 11  1  6  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005734

>  <SMILES>
CNC(=O)[C@@H]1CCO[C@@H]2CCN(Cc3ccc(C)cc3)C[C@@H]21

$$$$
SWF005735
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2226    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1288   -3.3008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1778   -2.9918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005735

>  <SMILES>
O=C(NCC1CCC2C1OCCN2CC1CC1)c1cnccn1

$$$$
SWF005736
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005736

>  <SMILES>
CCN1CCN(C)C2(CCN(C(=O)c3ccsc3)CC2)C1=O

$$$$
SWF005737
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9352    1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1820   -1.5146   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4938   -2.2720   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005737

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(Cc2cccnc2)CC1

$$$$
SWF005738
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    4.8970   -1.5409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  5  3  1  6  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 23 27  2  0  0  0  0
 25 28  2  0  0  0  0
  5  6  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 24 27  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005738

>  <SMILES>
Cc1nc(-c2ccccc2)nc2c1COCC21CCN(Cc2ccccc2)C1

$$$$
SWF005739
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005739

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)CC2CCOCC2)CC1

$$$$
SWF005740
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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    2.6234   -0.7573   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9352    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3117   -1.5146   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0720   -2.1307   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0855   -1.0051   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2675   -3.2771   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1263   -0.5817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
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 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 22 23  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005740

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(Cc2cnn(C)c2)CC1

$$$$
SWF005741
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    8.4160   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 22 23  2  0  0  0  0
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 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005741

>  <SMILES>
Cc1cccc(C(=O)N2C[C@H]3[C@@H](CCOCc4ccncc4)CO[C@H]3C2)c1

$$$$
SWF005742
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.3301    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1472   -1.8090   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  3  1  1  6  0  0  0
  2  4  1  0  0  0  0
  2  5  1  6  0  0  0
  3  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005742

>  <SMILES>
c1cncc(CN2CC[C@H]3O[C@@H](COCC4CC4)CC[C@H]32)c1

$$$$
SWF005743
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    2.4844   -0.4899   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3101   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -2.2691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3101    3.6520   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
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 25 26  1  0  0  0  0
  6 10  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005743

>  <SMILES>
CCc1ccc(CN2CCC(C(=O)N3CCC3)(n3cccn3)CC2)cc1

$$$$
SWF005744
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.8970   -1.5409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 11 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005744

>  <SMILES>
CCN1CCC2(COCc3c(C)nc(-c4ccccc4)nc32)C1

$$$$
SWF005745
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005745

>  <SMILES>
COc1cc(C(=O)N2CCC3(C2)Cn2ccnc2CN3C)on1

$$$$
SWF005746
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005746

>  <SMILES>
O=C(N1CCC1)C1(n2cccn2)CCN(Cc2ccc(Cl)cc2)CC1

$$$$
SWF005747
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005747

>  <SMILES>
CNC(=O)N1CCC2(COCc3c(C)nc(-c4ccccc4)nc32)C1

$$$$
SWF005748
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005748

>  <SMILES>
CC(=O)N1C[C@@H]2[C@H](NC(=O)C3CCOC3)c3ccccc3[C@@H]2C1

$$$$
SWF005749
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005749

>  <SMILES>
COC1CCC2(CCN(C(=O)Cn3ccccc3=O)CC2)c2ccccc21

$$$$
SWF005750
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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    3.2767    3.8738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF005750

>  <SMILES>
COCCNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C2CC=CC2)C1

$$$$
SWF005751
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    2.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    3.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005751

>  <SMILES>
CCn1cc(CN2CC3(CC(OCc4ccccn4)CCO3)C2)cn1

$$$$
SWF005752
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
   10.4307   -2.8480   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.4361   -2.9525   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8484   -2.1435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6728   -0.5254   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2715   -1.5435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005752

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@@]2(CCN(C(=O)c3cccc(Cl)n3)C2)C1

$$$$
SWF005753
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.4128    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  6  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005753

>  <SMILES>
c1cnc(N2CC3(C2)OCCC3CCOCc2cccnc2)nc1

$$$$
SWF005754
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    4.2902   -8.0700   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8230   -7.7582   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  1  0  0  0
 18 21  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005754

>  <SMILES>
O=C1NC2(CCN(S(=O)(=O)c3ccccc3)CC2)[C@H]2CN(CC3CCCC3)C[C@@H]12

$$$$
SWF005755
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 17 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005755

>  <SMILES>
O=C1CC[C@H]2[C@H](CCN2C(=O)C2CC=CC2)N1Cc1cccnc1

$$$$
SWF005756
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.8971   -7.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  1  0  0  0
 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005756

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CC1)CC(Nc1ncccn1)CCO2

$$$$
SWF005757
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  1  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  6  0  0  0
 22 24  1  6  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 13  2  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005757

>  <SMILES>
O=C(c1ccc2n1CCN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)CC2)N1CCCC1

$$$$
SWF005758
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
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  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  1  6  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005758

>  <SMILES>
O=C(Cc1ccccc1)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF005759
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 14 20  1  6  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005759

>  <SMILES>
CCN1CCO[C@H]2CCN(C(=O)c3cc(C)cc(C)c3)C[C@@H]21

$$$$
SWF005760
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005760

>  <SMILES>
O=C(C1=NO[C@@H]2CN(C(=O)C3(F)CCC3)C[C@H]12)N1CCCC1

$$$$
SWF005761
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005761

>  <SMILES>
O=C(C1CC=CC1)N1CCCC2(CC1)CCN(CC1CCC1)C2=O

$$$$
SWF005762
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   11.2792   -1.6106   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005762

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CCN(c2ccsc2)C3=O)C1

$$$$
SWF005763
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005763

>  <SMILES>
CC(C)NC(=O)N1CCC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF005764
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    5.1962   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005764

>  <SMILES>
Cc1ccc(C(=O)N2CC3(CC(CCOc4ncccn4)CCO3)C2)o1

$$$$
SWF005765
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    0.5920    5.2023   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005765

>  <SMILES>
CNC(=O)C1CCCC12CCN(Cc1cncc(Cl)c1)C2

$$$$
SWF005766
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    2.5981   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005766

>  <SMILES>
O=C(c1ccccc1)N1CCC2(CC1)CC(Nc1ncccn1)CCO2

$$$$
SWF005767
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005767

>  <SMILES>
Cn1cc(CN2CCC3(CC2)Cc2ccccc2CNC3=O)cn1

$$$$
SWF005768
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.2497   -4.3738   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005768

>  <SMILES>
CC(C)N1CCOC2CN(C(=O)c3ncn(C)n3)CCC2C1

$$$$
SWF005769
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005769

>  <SMILES>
Cc1nc(CN2CCO[C@@H]3CN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)CC[C@@H]3C2)cs1

$$$$
SWF005770
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005770

>  <SMILES>
CC1CC(C(=O)N2CC[C@H]3OC[C@@H](C(=O)N(C)C)C[C@H]3C2)C1

$$$$
SWF005771
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005771

>  <SMILES>
N#CC1(C(=O)N2CCOC3(COCCN(c4cnccn4)C3)C2)CCCC1

$$$$
SWF005772
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF005772

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(CCOc3ncccn3)CCO2)C1

$$$$
SWF005773
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 30 32  2  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF005773

>  <SMILES>
CN1CCn2c(C(=O)NCC3CCCCC3)nnc2C12CCN(Cc1ccccc1)CC2

$$$$
SWF005774
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 11 16  2  0  0  0  0
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 14 18  1  0  0  0  0
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 23 24  1  0  0  0  0
 10 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF005774

>  <SMILES>
COCCN1CCO[C@H]2CCN(C(=O)c3ncnc(C)c3C)C[C@@H]21

$$$$
SWF005775
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
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 17 18  1  0  0  0  0
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 13 15  1  6  0  0  0
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M  END
>  <HTSID>
SWF005775

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(Cc3cccnc3)C[C@H]12)c1ccco1

$$$$
SWF005776
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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    1.0252   -3.7327   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005776

>  <SMILES>
Cc1noc(C)c1CN1C[C@@H]2[C@H](CN3CCCC3)CO[C@@H]2C1

$$$$
SWF005777
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.2753    5.1981   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3155    5.4786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0784    6.4501   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8012    7.1411   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6328    5.0679   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1471    3.4054   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  6  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  7  9  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005777

>  <SMILES>
COCCN1CCCC12CCCN(C(=O)Cc1cccc(F)c1F)CC2

$$$$
SWF005778
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005778

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2cocn2)CC1

$$$$
SWF005779
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.6808   -0.5296   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005779

>  <SMILES>
Cn1ccc(CC(=O)N2C[C@@H]3OCCN(S(C)(=O)=O)[C@@H]3C2)n1

$$$$
SWF005780
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005780

>  <SMILES>
CC1c2nc(CC(=O)NCC3CC3)cn2CCN1C1CCOCC1

$$$$
SWF005781
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005781

>  <SMILES>
O=C(N1CCC1)C1(n2cccn2)CCN(Cc2nccs2)CC1

$$$$
SWF005782
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 21 24  2  0  0  0  0
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 15 16  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005782

>  <SMILES>
CS(=O)(=O)CCN1CC2(CCCN(Cc3cccc(F)c3)C2)C1=O

$$$$
SWF005783
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005783

>  <SMILES>
CCOCC(=O)N1CC2(C1)OCCC2COc1ccccn1

$$$$
SWF005784
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005784

>  <SMILES>
O=C(c1cscn1)N1C[C@@H]2CN(c3ncc(F)cn3)C[C@@H]2C1

$$$$
SWF005785
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005785

>  <SMILES>
CC(C)CN1CCC2(CCN(Cc3ccccn3)CC2)C1=O

$$$$
SWF005786
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005786

>  <SMILES>
Cn1c(C(=O)N2CCCC3(CCN(c4cccnc4)C3=O)C2)cccc1=O

$$$$
SWF005787
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005787

>  <SMILES>
Cc1nnc(N2CC3(CC(OCc4ccccn4)CCO3)C2)s1

$$$$
SWF005788
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005788

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(C(=O)c2ccncn2)C1

$$$$
SWF005789
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 16 18  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005789

>  <SMILES>
O=C(NC1CC1)C1(Nc2ccc(F)cn2)CCN(CC2CCCCC2)CC1

$$$$
SWF005790
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    2.7026    0.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 13 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005790

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(C(=O)Cc2cccs2)C1

$$$$
SWF005791
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005791

>  <SMILES>
O=C(c1cncnc1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF005792
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005792

>  <SMILES>
Cc1ccc(CN2CCc3oc(C(=O)N4CC(C)CC(C)C4)nc3C2)cc1

$$$$
SWF005793
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -1.3061   -4.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005793

>  <SMILES>
Cc1cnc(NCCC2CCOC23CN(C(=O)c2cnccn2)C3)nc1

$$$$
SWF005794
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 12 11  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005794

>  <SMILES>
O=C(c1ccco1)N1C[C@H]2CN(C(=O)Cc3ccc(F)cn3)[C@H]2C1

$$$$
SWF005795
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  1  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8 10  1  0  0  0  0
 13 17  1  0  0  0  0
 19 20  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005795

>  <SMILES>
O=C(CCc1ccc[nH]1)N1C[C@H](OCc2ccncc2)[C@H]2OCCC[C@H]21

$$$$
SWF005796
Actelion Java MolfileCreator 1.0

 29 31  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 15 13  1  1  0  0  0
 14 16  1  1  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  1  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005796

>  <SMILES>
CC(C)N1[C@H](C(=O)NCCN(C)C)C[C@@H]2CN(C(=O)Cc3ccc(F)cn3)C[C@@H]21

$$$$
SWF005797
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 12  1  0  0  0  0
  9 11  1  0  0  0  0
 14 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005797

>  <SMILES>
CC1CC(C(=O)N2C[C@H](OCc3ccccn3)[C@H]3OCCC[C@H]32)C1

$$$$
SWF005798
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.9462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8655    0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
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  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005798

>  <SMILES>
O=C(CC1=CCCCC1)N1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF005799
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005799

>  <SMILES>
COCCN1CC2(COCCN(Cc3ccccc3C)C2)CC1=O

$$$$
SWF005800
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8 12  1  0  0  0  0
  9 11  1  0  0  0  0
 14 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005800

>  <SMILES>
CC1CC(C(=O)N2C[C@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)C1

$$$$
SWF005801
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 11 16  1  6  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005801

>  <SMILES>
CC1CCC(C(=O)N2C[C@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)CC1

$$$$
SWF005802
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4664   -6.7850   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  1  0  0  0  0
  5  6  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF005802

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(Cc1cccnc1)C2C

$$$$
SWF005803
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
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 12 13  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005803

>  <SMILES>
Cn1cc(CN2CCC3(CC2)CN(Cc2ccncc2)Cc2ccccc23)cn1

$$$$
SWF005804
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF005804

>  <SMILES>
O=C(C1CC(O)C1)N1CCOC2CCC1C2OCc1cccnc1

$$$$
SWF005805
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005805

>  <SMILES>
O=C(NC[C@@H]1CO[C@@H]2CN(C(=O)CC3CC3)C[C@H]12)c1ccncc1

$$$$
SWF005806
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
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  5  6  1  0  0  0  0
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 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005806

>  <SMILES>
CNC(=O)C[C@H]1C[C@H]2CN(C(=O)c3cc(C)cs3)C[C@H]2O1

$$$$
SWF005807
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
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 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF005807

>  <SMILES>
O=C(c1cccs1)N1CCCC(c2nc3ccc(-c4cccnc4)cn3n2)C1

$$$$
SWF005808
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -2.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
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  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005808

>  <SMILES>
CC(=O)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF005809
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005809

>  <SMILES>
CCCC(C)N1C[C@H]2C(=O)NC3(CCN(C(=O)c4ccc(C)cc4)CC3)[C@H]2C1

$$$$
SWF005810
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 14 12  1  1  0  0  0
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 13 16  1  1  0  0  0
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 15 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF005810

>  <SMILES>
CCn1cc(CN2C[C@@H](C(=O)NCC(F)(F)F)C[C@H]3OCC[C@H]32)cn1

$$$$
SWF005811
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  7  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005811

>  <SMILES>
COCCN1CC2(COCCN(Cc3cccc(F)c3)C2)CC1=O

$$$$
SWF005812
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005812

>  <SMILES>
O=C(C[C@@H]1C[C@H]2CN(C(=O)C3CC(F)(F)C3)C[C@H]2O1)N1CCC1

$$$$
SWF005813
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.2948   -6.1228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6066   -4.6555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9770   -4.0454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2760   -4.7954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5750   -4.0454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.8741   -4.7954   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.1731   -4.0454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005813

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2CCC(C)C

$$$$
SWF005814
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
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 22 26  2  0  0  0  0
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 10 13  1  0  0  0  0
 12 15  1  0  0  0  0
 23 26  1  0  0  0  0
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M  END
>  <HTSID>
SWF005814

>  <SMILES>
O=C(C1[C@H]2COC[C@@H]12)N1CC[C@@H](OCC2CC2)[C@H](Cc2ccccc2)C1

$$$$
SWF005815
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    5.0080   -3.4237   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 25 27  2  0  0  0  0
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 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF005815

>  <SMILES>
CCCC(C)N1C[C@H]2C(=O)NC3(CCN(C(=O)c4ccccc4)CC3)[C@H]2C1

$$$$
SWF005816
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
   10.5415    3.8290   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.5904    3.5200   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.6883    2.9020   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3610    5.5274   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005816

>  <SMILES>
COCc1cccc(-c2cnc3n2CCN(C(=O)c2cccc(F)c2C)CC3)c1

$$$$
SWF005817
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 20 21  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005817

>  <SMILES>
Cc1nc(C(=O)N2Cc3cncn3CCC2COc2ccccc2)c[nH]1

$$$$
SWF005818
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF005818

>  <SMILES>
O=C(c1ccnnc1)N1CCc2ncc(-c3cnn(CC4CC4)c3)n2CC1

$$$$
SWF005819
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    6.0227    8.4411   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005819

>  <SMILES>
Cc1ccsc1CN1CC[C@]2(CCC[C@@H](CNC(=O)N(C)C)O2)C1

$$$$
SWF005820
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 11 10  1  1  0  0  0
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 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 24 26  1  0  0  0  0
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 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005820

>  <SMILES>
O=C(CC1CN(CC2CCOCC2)Cc2ccnn21)NCc1cccs1

$$$$
SWF005821
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 22 24  1  0  0  0  0
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 10 11  1  0  0  0  0
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M  END
>  <HTSID>
SWF005821

>  <SMILES>
CC1CC(C(=O)N2CC[C@H]3C[C@@H](C(=O)Nc4cnccn4)O[C@@H]3C2)C1

$$$$
SWF005822
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  5  7  1  0  0  0  0
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF005822

>  <SMILES>
c1ccc(CN2CCC3(CC(Nc4cccnc4)CO3)C2)nc1

$$$$
SWF005823
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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   -3.8971   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
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 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
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 25 27  2  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005823

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)c4cc[nH]c4)CC3)CC2=O)cc1

$$$$
SWF005824
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005824

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(=O)N(CC2CC2)C3)C1

$$$$
SWF005825
Actelion Java MolfileCreator 1.0

 33 38  0  0  0  0  0  0  0  0999 V2000
    5.1726   -6.3685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  9 15  1  6  0  0  0
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 11 17  1  0  0  0  0
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 15 19  1  0  0  0  0
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 29 30  1  0  0  0  0
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 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
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 11 13  2  0  0  0  0
 18 21  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <HTSID>
SWF005825

>  <SMILES>
Cc1nc2ccccn2c1C(=O)N1CCC2(CCc3nnc(C(=O)NCC4CC4)n3CC2)C1

$$$$
SWF005826
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.5468   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0413   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2413    1.9487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2413    0.9487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
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 10  9  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005826

>  <SMILES>
Cc1nc(COC[C@]23COC[C@H]2CN(Cc2ccoc2)C3)cs1

$$$$
SWF005827
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005827

>  <SMILES>
CN(C)C(=O)NC1CC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF005828
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9230   -2.0878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -3.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5411   -2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0411   -3.6266   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 11 14  1  0  0  0  0
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 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 13  1  0  0  0  0
 11 10  1  1  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005828

>  <SMILES>
O=C(NC1CCC1)C1=NO[C@@H]2CN(C(=O)C3CC(O)C3)C[C@H]12

$$$$
SWF005829
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3301   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  9 10  2  0  0  0  0
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 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005829

>  <SMILES>
O=C1COC2(CCN(C(=O)Cc3cccc(F)c3)CC2)CN1

$$$$
SWF005830
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.9211   -2.0032   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5902   -1.2601   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5683   -1.4680   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812   -0.3090   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9751   -2.3815   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3115   -0.7989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8690    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9696   -2.2770   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1775   -1.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2812    1.3090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005830

>  <SMILES>
O=C(NC1CCc2onc(C(=O)N3CCCC3)c2C1)c1cocn1

$$$$
SWF005831
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9282   -1.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4282   -2.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4282   -0.6340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005831

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(NS(C)(=O)=O)CCO3)C1

$$$$
SWF005832
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1121   -2.2458   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2394    0.0950   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9875   -3.2661   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6727   -0.3472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4707   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4395   -4.6624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2207   -1.7435   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3747   -5.8351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7165   -1.8556   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8580   -5.6116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5615   -0.6162   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0573   -0.7283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9107    0.7353   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005832

>  <SMILES>
Cc1cccc(CN2CCN(Cc3cccnc3)c3ncccc3C2)n1

$$$$
SWF005833
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
   11.9499   -1.5561   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.4827   -1.2442   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1067   -3.0479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8726    0.1261   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7327   -2.5433   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7364   -3.6580   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1104   -4.1626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7543    1.3396   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3808    0.2829   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.8932   -5.1498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3604   -5.4616   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4368    1.4486   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  2  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  6  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005833

>  <SMILES>
O=C(c1cc2c(s1)CCC2)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF005834
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005834

>  <SMILES>
COCCN1CCCC2(CCN(C(=O)c3cccnc3)CC2)C1=O

$$$$
SWF005835
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.7681   -0.3752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4372   -1.1183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0989    0.3680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0249   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5112    0.2939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2159   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005835

>  <SMILES>
CS(=O)(=O)N1CC[C@@H]2CN(C(=O)CCc3ccc[nH]3)C[C@@H]21

$$$$
SWF005836
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1383   -0.8004   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3293   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8074   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5861   -2.8708   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1081   -3.2309   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9612   -2.3038   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 14 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005836

>  <SMILES>
O=C(CCF)N1CC2(C1)OCCC2CCOc1ccccn1

$$$$
SWF005837
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9385   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3119   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9221   -4.0808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.6505   -6.6646   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1423   -6.8214   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.3789   -9.2484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4114   -8.1604   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8414  -10.6488   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2417  -11.1864   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005837

>  <SMILES>
COCCN1CC2(CCN(C(=O)CC3(O)CCC3)CC2)CC1=O

$$$$
SWF005838
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9487   -2.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808   -3.9345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -2.5685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -4.3005   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9016   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6  9  1  0  0  0  0
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  8 11  1  6  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF005838

>  <SMILES>
COc1cc(C(=O)N2C[C@@H]3OCCN(S(C)(=O)=O)[C@@H]3C2)on1

$$$$
SWF005839
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.7634   -4.4049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6295   -2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6295   -1.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3615   -2.9049   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955   -4.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4955   -1.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.6295   -4.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
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 11 16  2  0  0  0  0
 12 17  2  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005839

>  <SMILES>
CCC1COC2(CCN(C(=O)c3cccnc3C(N)=O)C2)C1

$$$$
SWF005840
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    1.9907   -4.0306   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4904   -3.8730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4994   -4.9936   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2443   -2.5671   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8769   -4.3803   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9983   -1.2612   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7694   -2.2536   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6578   -3.0292   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9154   -2.4068   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6116    0.1163   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9893   -0.1406   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6118   -0.7540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3843   -2.3235   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.3059   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4972   -0.7884   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3059    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1105    0.5892   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6118   -0.7540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3059   -3.0158   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3305    1.4755   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9529    2.0888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6118   -2.2619   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 23 26  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005840

>  <SMILES>
O=C1NCCC12CN(Cc1cccnc1)CC21CCN(CC2CC2)CC1

$$$$
SWF005841
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.2104   -4.4155   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0025   -3.4373   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4672   -5.0846   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5377   -1.7900   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6990   -1.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4347    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005841

>  <SMILES>
CSCC(=O)N1CC2(C1)OCCC2CCOCc1ccccn1

$$$$
SWF005842
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  1  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
  7  9  1  0  0  0  0
 10 12  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005842

>  <SMILES>
c1ccc(CN2CCOC3(CCCN(c4ncccn4)C3)C2)nc1

$$$$
SWF005843
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    9.0619   -2.5978   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783   -0.1727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3492   -4.8565   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8128   -6.2831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005843

>  <SMILES>
CN1C(=O)c2cccnc2C12CCN(C(=O)c1cc(C3CC3)on1)CC2

$$$$
SWF005844
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.8692    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5196    2.3412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5817    3.2040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9820    3.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005844

>  <SMILES>
CN(C)C(=O)COC1CSC2(C1)CN(Cc1cccnc1)C2

$$$$
SWF005845
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005845

>  <SMILES>
CNC(=O)NC1CC2(CCN(C(C)=O)CC2)c2cc(C)ccc21

$$$$
SWF005846
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005846

>  <SMILES>
O=C1CCCN1CCC1CCOC12CN(Cc1ccncc1)C2

$$$$
SWF005847
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005847

>  <SMILES>
CNC(=O)C1COC2(CN(Cc3cccnc3)C2)CN1CC1CC1

$$$$
SWF005848
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005848

>  <SMILES>
Cc1ccccc1C(=O)N1CCC2(C1)CN(c1cnn(C)c1)C(=O)CN2C

$$$$
SWF005849
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 21 23  1  0  0  0  0
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 15 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005849

>  <SMILES>
COCCN1CC2(CCN(C(=O)C(C)C)CC2)C(COC)C1=O

$$$$
SWF005850
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
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 17 22  2  0  0  0  0
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 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 27 29  1  0  0  0  0
 28 30  2  0  0  0  0
 29 31  2  0  0  0  0
  9 10  1  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 23 24  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005850

>  <SMILES>
O=C(NCc1cccnc1)c1nc(-c2cn(Cc3ccccc3)cn2)n2ccccc12

$$$$
SWF005851
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
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 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005851

>  <SMILES>
O=C(C1CC(O)C1)N1CCC2(CCN(Cc3nccs3)C2)CC1

$$$$
SWF005852
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  2  0  0  0  0
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 18 22  2  0  0  0  0
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 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
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 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF005852

>  <SMILES>
c1ccc(CN2CC3(CC(OCc4cccnc4)CCO3)C2)nc1

$$$$
SWF005853
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   10.0260   -2.1374   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  6  0  0  0
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 10 15  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005853

>  <SMILES>
COc1cnccc1C(=O)N1C[C@@H]2C(C(=O)NC3CC3)=NO[C@@H]2C1

$$$$
SWF005854
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005854

>  <SMILES>
O=C(C1CCOC1)N1CCC2(CC1)CN(Cc1cccnc1)CCO2

$$$$
SWF005855
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  1  0  0  0
 11 13  1  1  0  0  0
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 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005855

>  <SMILES>
Cn1cc(CN2CC[C@@H]3CN(Cc4ccco4)C[C@@H]3C2)cn1

$$$$
SWF005856
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.0360   -0.3752   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.7051   -1.1183   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3669    0.3680   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.7792    0.2939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  8 10  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005856

>  <SMILES>
CCc1ccc(C(=O)N2C[C@H]3CCN(S(C)(=O)=O)[C@H]3C2)cn1

$$$$
SWF005857
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
    5.1962   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
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 10 14  2  0  0  0  0
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 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
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 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005857

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(COCC3CC3)CCN2CC2CC2)C1

$$$$
SWF005858
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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  4  6  1  0  0  0  0
 10 13  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005858

>  <SMILES>
c1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CN3CCCC3)C2)ccn1

$$$$
SWF005859
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.2933   -3.7240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 12 13  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF005859

>  <SMILES>
CNC(=O)C1CCc2ncc(CNC(=O)CCc3ccc[nH]3)n2C1

$$$$
SWF005860
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005860

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CC[C@@H]2CN(C3CCOCC3)CCO[C@@H]2C1

$$$$
SWF005861
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF005861

>  <SMILES>
COc1cc(C(=O)N2CC3(CCN(S(C)(=O)=O)C3)C2)on1

$$$$
SWF005862
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005862

>  <SMILES>
CS(=O)(=O)NCC1CN(C(=O)c2ccsc2)Cc2cncn21

$$$$
SWF005863
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF005863

>  <SMILES>
O=C(c1ccsc1)N1CCC(c2nc3ccc(N4CCCC4)cn3n2)CC1

$$$$
SWF005864
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005864

>  <SMILES>
COCCN1CC[C@@]2(CN(C(C)C)C[C@@H]2c2ccccc2)C1=O

$$$$
SWF005865
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
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  9 10  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005865

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@@]2(CCN(C(=O)c3ccnc(C(F)(F)F)c3)C2)C1

$$$$
SWF005866
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    6.9128    5.5326   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4128    4.6665   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 12  2  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 25 26  2  0  0  0  0
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 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
  6  8  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 21 23  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005866

>  <SMILES>
O=C(c1ccoc1)N1CCCC(c2nc3ccc(-c4cccc(F)c4)cn3n2)C1

$$$$
SWF005867
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005867

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(CC(OCC3CC3)CS2)C1

$$$$
SWF005868
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 14  1  0  0  0  0
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 18 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005868

>  <SMILES>
Cn1cnc(C(=O)N2CCc3ncnc(-c4cccnc4)c3C2)n1

$$$$
SWF005869
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.6337    2.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005869

>  <SMILES>
Cc1cnc(C(=O)N2CCC3(CC3C(=O)N3CCCC3)C2)cn1

$$$$
SWF005870
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005870

>  <SMILES>
Cc1cncc(OCCC2CCOC3(C2)CN(C(=O)N(C)C)C3)n1

$$$$
SWF005871
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005871

>  <SMILES>
O=C(NC1CS(=O)(=O)C1)[C@H]1C[C@H]2OCC[C@H]2N(Cc2c[nH]c3ccc(F)cc23)C1

$$$$
SWF005872
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005872

>  <SMILES>
Cn1ccc(N2CCC3(CCN(C(=O)c4cc[nH]n4)CC3)C2=O)n1

$$$$
SWF005873
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005873

>  <SMILES>
COc1cnccc1C(=O)N1CCCC2(CCN(C)C2=O)C1

$$$$
SWF005874
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005874

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CNC(=O)CO3)cn1

$$$$
SWF005875
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005875

>  <SMILES>
CN(C)C(=O)COCC[C@H]1CO[C@H]2CN(Cc3cccnc3)C[C@@H]12

$$$$
SWF005876
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8813    2.4562   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005876

>  <SMILES>
O=C(N1CCCC2(COCCN(c3nncs3)C2)C1)C1(F)CCC1

$$$$
SWF005877
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4641    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  1  0  0  0
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 10 13  1  0  0  0  0
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 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005877

>  <SMILES>
CN(C)C(=O)[C@@H]1CO[C@@H]2CCN(C(=O)c3cc[nH]n3)C[C@@H]2C1

$$$$
SWF005878
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005878

>  <SMILES>
O=C(NC[C@@H]1OC[C@@H]2CN(C(=O)C3CC(O)C3)CC[C@@H]21)c1ccncc1

$$$$
SWF005879
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005879

>  <SMILES>
Cc1ccc(C)c(CN2CC3(CC(OCC(=O)N(C)C)CCO3)C2)c1

$$$$
SWF005880
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005880

>  <SMILES>
COC[C@@H]1CN(C)C[C@@]12CCN(C(=O)c1cc(C)cs1)C2

$$$$
SWF005881
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10  6  1  1  0  0  0
 11  7  1  1  0  0  0
 10 12  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF005881

>  <SMILES>
O=S(=O)(C1CC1)N1C[C@H]2CN(Cc3ccccn3)C[C@H]2C1

$$$$
SWF005882
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 10 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  2  0  0  0  0
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 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
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 13 15  1  0  0  0  0
 18 22  1  0  0  0  0
 20 21  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005882

>  <SMILES>
O=C(c1cc[nH]n1)N1Cc2c(-c3ccccc3)ncnc2-n2nccc2C1

$$$$
SWF005883
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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  6  7  1  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005883

>  <SMILES>
c1ccc(OC2CCOC3(C2)CN(Cc2ccsc2)C3)nc1

$$$$
SWF005884
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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 28 30  2  0  0  0  0
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 12 14  1  0  0  0  0
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 21 23  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005884

>  <SMILES>
O=C(c1ccccn1)N1CCCC(c2nc3ccc(-c4cccc(F)c4)cn3n2)C1

$$$$
SWF005885
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  1  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
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 10 14  2  0  0  0  0
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 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF005885

>  <SMILES>
O=C(Cc1ccco1)N1CCC2(CC1)CC(CNS(=O)(=O)c1ccccc1)O2

$$$$
SWF005886
Actelion Java MolfileCreator 1.0

 28 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005886

>  <SMILES>
O=C1N(Cc2ccccc2)CC[C@@]12C[C@H]1CN(S(=O)(=O)c3cccs3)C[C@@H]2O1

$$$$
SWF005887
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.6394    1.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 19 21  1  0  0  0  0
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 20 23  1  0  0  0  0
  5  7  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF005887

>  <SMILES>
CC(C)N(C)CC(=O)N1CCC2(CC1)CC(=O)N(CC1CC1)C2

$$$$
SWF005888
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005888

>  <SMILES>
Cc1cccc(COCCC2CCOC23CN(C(=O)c2ccncc2)C3)n1

$$$$
SWF005889
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 27 29  1  0  0  0  0
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M  END
>  <HTSID>
SWF005889

>  <SMILES>
O=C(NC1CCC1)c1nnc2n1CC1(CC2)CCN(Cc2cccc(F)c2)CC1

$$$$
SWF005890
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
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  7 11  1  6  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005890

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)C3[C@H]4COC[C@@H]34)CCC21

$$$$
SWF005891
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
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 24 25  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005891

>  <SMILES>
Cc1cccc(NC(=O)c2cc(-c3cnc(-c4ccccc4)nc3)cn2CC2CC2)c1

$$$$
SWF005892
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.8281    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005892

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)n1

$$$$
SWF005893
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 11 13  1  0  0  0  0
 16 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005893

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2CCN(C(=O)C3(F)CC3)C[C@@H]21

$$$$
SWF005894
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005894

>  <SMILES>
CO[C@@H]1CCN(C(=O)CN(C)C(C)C)C[C@H]1Cc1ccccc1

$$$$
SWF005895
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4636   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 10  1  0  0  0  0
 11  8  1  1  0  0  0
 12  9  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005895

>  <SMILES>
COCCNC(=O)C[C@@H]1C[C@H]2CN(Cc3cccnc3OC)C[C@H]2O1

$$$$
SWF005896
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    3.4641    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  0  0  0  0
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 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
  6  9  1  0  0  0  0
 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005896

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)c3cccc(C)c3)C2)CN1CC1CC1

$$$$
SWF005897
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5498    7.1791   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005897

>  <SMILES>
C=CCN1CCC2(CCN(C(=O)c3cnc(C)cn3)CC2)C1=O

$$$$
SWF005898
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4209   -2.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549   -0.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2869    0.2929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  8  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005898

>  <SMILES>
Cc1ccncc1COC1CCOC2(C1)CN(C(=O)CC1CC1)C2

$$$$
SWF005899
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005899

>  <SMILES>
N#Cc1ccc(OC[C@@H]2CO[C@@H]3CN(C(=O)c4csnn4)C[C@H]23)cc1

$$$$
SWF005900
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   11.9651    7.5605   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   12.4697    5.1865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   13.7688    5.9365   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4606    8.5184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4280    3.3370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005900

>  <SMILES>
Cc1ccc(CN2CCC3(CCc4nnc(C(=O)NC(C)C)n4C3)CC2)s1

$$$$
SWF005901
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    8.5354   -5.0285   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF005901

>  <SMILES>
CC(C)C(=O)NC[C@@H]1CO[C@@H]2CN(Cc3cccc(F)c3)C[C@H]12

$$$$
SWF005902
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    5.1962   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005902

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CCN(Cc4cccnc4)CC3)CC2)n1

$$$$
SWF005903
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  9 10  2  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005903

>  <SMILES>
CC1CC1C(=O)N1CC2(CCC(CNC(=O)c3ccno3)CO2)C1

$$$$
SWF005904
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  7  4  1  1  0  0  0
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  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 14 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 17  1  0  0  0  0
 14 15  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005904

>  <SMILES>
N#Cc1cccc(N2CC3(CCN(C(=O)c4cc[nH]n4)C3)CC2=O)c1

$$$$
SWF005905
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  1  0  0  0  0
 27 30  2  0  0  0  0
 29 31  1  0  0  0  0
 10 15  1  0  0  0  0
 11 13  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <HTSID>
SWF005905

>  <SMILES>
COc1cccc(-c2ccc3nc(C4CCCN(C(=O)c5ccoc5C)C4)nn3c2)c1

$$$$
SWF005906
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7342   -1.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4352   -1.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF005906

>  <SMILES>
CCn1cc(CN2CC3(CCC(CN4CCOCC4)CO3)C2)cn1

$$$$
SWF005907
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  6  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  6  0  0  0
  7 13  1  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 12 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 17 22  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  2  0  0  0  0
  8 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 24  1  0  0  0  0
 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005907

>  <SMILES>
Cn1nccc1[C@H]1CNC[C@@]12CCCN(Cc1cccnc1)C2=O

$$$$
SWF005908
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 18 20  1  0  0  0  0
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 11 13  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005908

>  <SMILES>
CC(C)(C)C(=O)N[C@@H]1c2ccccc2[C@@H]2CN(Cc3ccccc3)C[C@H]12

$$$$
SWF005909
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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    0.3569    1.8320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 27 29  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005909

>  <SMILES>
O=C(CN1CCC12CCCN(C(=O)c1ccc3ccccc3c1)C2)N1CCCC1

$$$$
SWF005910
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 15  2  0  0  0  0
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 15 18  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005910

>  <SMILES>
COCC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(CC3CCCCC3)C[C@H]12

$$$$
SWF005911
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8910    0.1285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4448    3.8909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2369    4.8690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7017    3.2217   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2858    5.1780   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5427    4.5089   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005911

>  <SMILES>
COCC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(Cc3ccccc3)C[C@H]12

$$$$
SWF005912
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2160    1.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0404    3.3385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.0349    3.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005912

>  <SMILES>
O=C(C1CC(F)C1)N1CCCC2(CCN(c3ccccc3)C2=O)C1

$$$$
SWF005913
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2463    1.1281   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7297    1.3456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4061    0.6091   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0294    2.2997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0408   -0.3218   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9773    2.6181   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4337    3.1029   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4819   -1.1999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9675    3.6180   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005913

>  <SMILES>
Cn1cnc(C(=O)N2CCOC3CCC2C3OCc2cccnc2)n1

$$$$
SWF005914
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    3.6808    1.2024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3366   -3.3605   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3092   -1.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9193   -3.6970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7978   -5.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3330   -6.7291   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  1  0  0  0
 17 20  2  0  0  0  0
 18 21  1  1  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  4  5  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005914

>  <SMILES>
CCCN1C[C@H]2C(=O)NC3(CCN(C(=O)Cc4ccsc4)CC3)[C@H]2C1

$$$$
SWF005915
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.3147   -2.5685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  1  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 15 21  1  0  0  0  0
 16 22  1  0  0  0  0
 17 23  1  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 18 20  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005915

>  <SMILES>
Cc1noc(C)c1CN1CCO[C@H]2CN(Cc3ccco3)C[C@H]21

$$$$
SWF005916
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.4128    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  1  1  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  1  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 12  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005916

>  <SMILES>
COCC(=O)N[C@@H]1c2ccccc2[C@@H]2CN(Cc3ccncc3)C[C@H]12

$$$$
SWF005917
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 12 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005917

>  <SMILES>
Cc1ccc(O)c(C(=O)N2CCC3(CC2)COC(CN2CCCC(C)C2)C3)c1

$$$$
SWF005918
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  2  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
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  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  1  0  0  0
 14 20  1  0  0  0  0
 15 21  1  0  0  0  0
 17 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 11 13  1  0  0  0  0
 16 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF005918

>  <SMILES>
O=C(CC1CCOCC1)N[C@@H]1c2ccccc2[C@@H]2CN(Cc3cccnc3)C[C@H]12

$$$$
SWF005919
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.7615   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005919

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(NC(=O)C(C)C)CO3)C1

$$$$
SWF005920
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0136   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005920

>  <SMILES>
O=C(C1=CCCC1)N1CC2(C1)OCCC2COc1ccccn1

$$$$
SWF005921
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.9783   -2.4783   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8443   -2.9783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005921

>  <SMILES>
Cc1nc(CN2CCO[C@H]3CN(C(=O)CC4(O)CCC4)C[C@H]32)cs1

$$$$
SWF005922
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005922

>  <SMILES>
CN(Cc1ccco1)C[C@@H]1OC[C@H]2CN(CC3CCOC3)CC[C@H]21

$$$$
SWF005923
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.1659   -6.2965   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF005923

>  <SMILES>
COCCN1CCO[C@@H]2CN(Cc3nccs3)CC[C@@H]2C1

$$$$
SWF005924
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
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 13 14  1  1  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005924

>  <SMILES>
Fc1ccc(CN2CCC3(C2)Cn2c(-c4ccsc4)cnc2CO3)cc1

$$$$
SWF005925
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005925

>  <SMILES>
CCN1CCO[C@H]2CCN(C(=O)Cc3cccc(F)c3)C[C@@H]21

$$$$
SWF005926
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005926

>  <SMILES>
O=C(C1CC(F)C1)N1CC[C@]2(CCC[C@H](CN3CCCC3)O2)C1

$$$$
SWF005927
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.5984    1.3640   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1862    2.1730   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7795    3.0865   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7850    3.1911   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3673    3.8955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.8116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3782    4.1046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9605    4.8091   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6589    1.4103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634    2.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9660    4.9136   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 15  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005927

>  <SMILES>
O=C(Cc1ccccn1)N1CCC2(CCCC2C(=O)N2CCOCC2)C1

$$$$
SWF005928
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9839   -3.3116   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7759   -4.2898   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -2.9049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8249   -4.5988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5191   -4.9589   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3092   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6170   -5.5769   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3112   -5.9370   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3601   -6.2460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8916   -1.4364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7105    0.2862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2983   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  2  0  0  0  0
  5 11  1  0  0  0  0
  7 12  1  1  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 12 17  2  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 21 25  2  0  0  0  0
  6  9  1  0  0  0  0
 13 14  1  0  0  0  0
 16 20  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005928

>  <SMILES>
NC(=O)N1C[C@@H](c2ccccc2)[C@@]2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF005929
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8317    0.6770   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0614    1.8630   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8754    1.0928   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  2  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  1  0  0  0
 20 23  1  0  0  0  0
  8 10  1  0  0  0  0
 17 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005929

>  <SMILES>
CN1CCO[C@H]2CCN(C(=O)c3cn(C)nc3C(F)(F)F)C[C@@H]21

$$$$
SWF005930
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.0124    1.0516   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6914    2.8919   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5472    2.0607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7037    3.0484   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  5  8  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005930

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)C4(F)CCC4)C3)C2=O)n1

$$$$
SWF005931
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.9666   -1.0374   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9885   -0.8295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0712   -2.0319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5817    0.0841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4885   -1.6955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1576   -2.4387   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1695    0.8931   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5872    0.1886   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9579    0.9657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8101   -0.4407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  5  2  0  0  0  0
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  4  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  6  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005931

>  <SMILES>
O=C(c1cccs1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF005932
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    6.8883   -8.0700   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4211   -7.7582   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8846   -9.1848   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  1  0  0  0
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 19 22  1  1  0  0  0
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 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005932

>  <SMILES>
CCCC(C)N1C[C@H]2C(=O)NC3(CCN(S(=O)(=O)c4ccccc4)CC3)[C@H]2C1

$$$$
SWF005933
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8255    1.1637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4946    1.9068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.0823    1.8328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  2  0  0  0  0
 17 14  1  1  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  6  0  0  0
 19 21  1  6  0  0  0
 20 22  1  0  0  0  0
 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005933

>  <SMILES>
CS(=O)(=O)N1CCCC12CCCN(C(=O)[C@H]1[C@@H]3COC[C@@H]31)C2

$$$$
SWF005934
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005934

>  <SMILES>
COc1cccc(S(=O)(=O)N2CC3(CC(OC)CS3)C2)c1

$$$$
SWF005935
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   11.4667   -0.9168   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.4630    0.1980   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 12 15  1  6  0  0  0
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 13 17  1  0  0  0  0
 16 18  1  1  0  0  0
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 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005935

>  <SMILES>
Fc1ccc(CN2CCO[C@H]3[C@H](OCC4CC4)CC[C@@H]32)cc1

$$$$
SWF005936
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
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 22 24  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005936

>  <SMILES>
O=C1CC2(CCN(C(=O)c3cc[nH]c3)CC2)CN1Cc1cccc(F)c1

$$$$
SWF005937
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.8052    7.2277   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  4  6  1  0  0  0  0
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  9  6  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
  9 10  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005937

>  <SMILES>
O=C(NCc1ccco1)[C@@H]1C[C@@H]2CCN(C(=O)CC3(O)CCC3)C[C@H]2O1

$$$$
SWF005938
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.2053    1.5341   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005938

>  <SMILES>
O=C(N1CCC2OCCCC2(COCc2ccncc2)C1)C1(F)CC1

$$$$
SWF005939
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -0.3579    0.9481   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2299    1.7572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2245    1.6526   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8936    2.3958   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3232    3.5367   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1549    2.8786   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3459    4.2799   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF005939

>  <SMILES>
COC[C@H]1CN(C)C[C@@]12CCN(C(=O)c1cc(OC)no1)C2

$$$$
SWF005940
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.1801   -2.6333   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1356   -2.9281   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  6  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7 10  1  0  0  0  0
  8  9  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005940

>  <SMILES>
COc1cc(CN2C[C@@H]3CN(C)CCO[C@@H]3C2)cc(OC)c1

$$$$
SWF005941
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6150    0.6096   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005941

>  <SMILES>
CC(C)N(C)C(=O)C1CN(c2ncccn2)CC12CCOCC2

$$$$
SWF005942
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005942

>  <SMILES>
O=C(/C=C/c1cccs1)N1CC[C@]2(C1)C(=O)NC[C@@H]2COc1cccnc1

$$$$
SWF005943
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.0672   -3.1667   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0148   -2.1681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
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 10  8  1  6  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
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 17 18  1  0  0  0  0
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  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005943

>  <SMILES>
O=C(N1CC[C@]2(C1)C(=O)NC[C@H]2COc1cccnc1)C1(F)CC1

$$$$
SWF005944
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 23 25  2  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005944

>  <SMILES>
COCCN1CC2(CCC1=O)CCN(C(=O)Cc1ccccc1)CC2

$$$$
SWF005945
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  6  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 13 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF005945

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CC1)CC(N(C)C)CO2

$$$$
SWF005946
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 21 26  1  0  0  0  0
 22 27  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 23 27  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005946

>  <SMILES>
N#CC1(C(=O)N2CC[C@]3(C2)C(=O)NC[C@@H]3COc2cccnc2)CCCC1

$$$$
SWF005947
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF005947

>  <SMILES>
CC1CCC(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)c2cnn(C)c2)C3)CC1

$$$$
SWF005948
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 16 19  2  0  0  0  0
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 23 25  1  0  0  0  0
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF005948

>  <SMILES>
CC(C)CC(=O)N1CCc2nc(C(=O)Nc3ccccc3)sc2CC1

$$$$
SWF005949
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005949

>  <SMILES>
CN(C)CCN1CCC2(CCCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)C2)C1=O

$$$$
SWF005950
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 20 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF005950

>  <SMILES>
O=C(CC1CC2(CCN(C(=O)c3cccs3)CC2)c2ccccc21)N1CCCC1

$$$$
SWF005951
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005951

>  <SMILES>
Cc1ccc(-c2cnc3n2CC2(CCN(Cc4cccc(F)c4)C2)OC3)cc1

$$$$
SWF005952
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005952

>  <SMILES>
O=S1(=O)c2ccccc2OC2(CCN(Cc3cccs3)C2)CN1Cc1ccccn1

$$$$
SWF005953
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 23  2  0  0  0  0
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 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005953

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H](O)[C@@H]1Cc1cccnc1

$$$$
SWF005954
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005954

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2cccnc2)N1Cc1cccc(F)c1F

$$$$
SWF005955
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.1667    3.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    4.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF005955

>  <SMILES>
Cc1ccc(CN2Cc3ccnn3C(CNC(=O)N(C)C)C2)s1

$$$$
SWF005956
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.6647   -1.8841   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF005956

>  <SMILES>
CN(Cc1ccco1)[C@@H]1CN(Cc2ccsc2)[C@@H]2CCCO[C@H]12

$$$$
SWF005957
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    2.8255    1.1637   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4946    1.9068   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005957

>  <SMILES>
CS(=O)(=O)N1CCCC12CCCN(C(=O)C1(F)CCC1)C2

$$$$
SWF005958
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  7 10  1  0  0  0  0
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 12  9  1  1  0  0  0
 11 13  2  0  0  0  0
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 22 24  2  0  0  0  0
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  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005958

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2ccncc2)N1Cc1ccc(F)cc1Cl

$$$$
SWF005959
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 14 17  1  1  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005959

>  <SMILES>
Fc1ccc(CN2C[C@@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)cc1

$$$$
SWF005960
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  4  8  1  0  0  0  0
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  8 12  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005960

>  <SMILES>
Cc1cc(C(=O)N2CC3(C2)OCCC3CCOc2ccccn2)c(C)o1

$$$$
SWF005961
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  6  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 14 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005961

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ccncn2)[C@@H]2CN(CC3CC3)C[C@@H]21

$$$$
SWF005962
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1312    3.1740   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  1  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
  8  9  1  0  0  0  0
 10 12  1  0  0  0  0
 20 23  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005962

>  <SMILES>
O=S(=O)(C1CC1)N1CC[C@@H](OCC2CC2)[C@@H]1Cc1ccccc1

$$$$
SWF005963
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  7  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005963

>  <SMILES>
CCS(=O)(=O)N1CC2(CC(OCc3ccccn3)CCO2)C1

$$$$
SWF005964
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 13 16  1  0  0  0  0
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 21 22  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005964

>  <SMILES>
N#CC1(C(=O)N2CCC3(CCC(=O)N3Cc3ccncc3)CC2)CCCC1

$$$$
SWF005965
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  5  8  1  0  0  0  0
 12 13  1  0  0  0  0
 18 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005965

>  <SMILES>
CN1CC(c2ccccc2)C2(CN(C(=O)C3(C#N)CCCC3)CCO2)C1=O

$$$$
SWF005966
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
    1.2324   -2.4069   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 29 31  2  0  0  0  0
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 21 25  1  0  0  0  0
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 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF005966

>  <SMILES>
O=C1N(Cc2cccnc2)CCOC12CN(Cc1ccccn1)CC2c1cccnc1

$$$$
SWF005967
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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 10 15  2  0  0  0  0
 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF005967

>  <SMILES>
COCCC1CCOC2(C1)CN(C(=O)c1ccccc1C)C2

$$$$
SWF005968
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 22 24  1  0  0  0  0
  7  8  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF005968

>  <SMILES>
CC(C)N1CCOC2(COCCN(Cc3ccc(F)c(F)c3)C2)C1

$$$$
SWF005969
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005969

>  <SMILES>
O=C(c1csnn1)N1CCC2(CC(=O)N(c3cncnc3)C2)C1

$$$$
SWF005970
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF005970

>  <SMILES>
Cc1cccc(CN2CCC3(CCc4nnc(C(=O)NC(C)C)n4C3)CC2)c1

$$$$
SWF005971
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
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  8  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 17 18  1  0  0  0  0
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 20 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF005971

>  <SMILES>
CC(C)N(C)Cc1cnc2n1CCN(Cc1ccc(F)cc1)C2

$$$$
SWF005972
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF005972

>  <SMILES>
Cc1ccc(C(=O)N2CC[C@]3(C2)C[C@H](NC(=O)N(C)C)C3)o1

$$$$
SWF005973
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  6  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005973

>  <SMILES>
O=C1CC[C@H]2[C@H](CCN2Cc2cccs2)N1CCN1CCOCC1

$$$$
SWF005974
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    4.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
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  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  7  8  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF005974

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCOC2(COCCN(c3ncccn3)C2)C1

$$$$
SWF005975
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.5981    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437    2.5933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    3.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 10 15  1  1  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  1  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005975

>  <SMILES>
O=C(NC1CC1)[C@@H]1CN(C(=O)c2cc[nH]c2)C[C@H]2OCC[C@H]21

$$$$
SWF005976
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 13 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5  7  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF005976

>  <SMILES>
O=C1CC2(CCN(C(=O)C3CC=CC3)CC2)CN1Cc1ccncc1

$$$$
SWF005977
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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  3  7  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  2  0  0  0  0
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 18 23  2  0  0  0  0
 19 24  2  0  0  0  0
 22 25  2  0  0  0  0
  4  7  1  0  0  0  0
  6  9  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005977

>  <SMILES>
Cc1ccccc1CN1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF005978
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005978

>  <SMILES>
c1ccc(COC2CCOC3(C2)CN(Cc2ccccn2)C3)nc1

$$$$
SWF005979
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1471    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1106    5.2348   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    5.2348   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    6.1165   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 14 19  2  0  0  0  0
 16 20  1  0  0  0  0
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 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
  8  9  1  0  0  0  0
 12 15  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005979

>  <SMILES>
COc1ccccc1OCC(=O)N1C[C@@H]2[C@H](CN(C)C)CO[C@@H]2C1

$$$$
SWF005980
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7570    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4935    5.4087   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 22 25  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005980

>  <SMILES>
Cc1cncc(COC2CCOC3(C2)CN(Cc2cc(C)on2)C3)c1

$$$$
SWF005981
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.0673    4.7989   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8763    5.3867   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3763    3.8479   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6853    4.7989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9641    3.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6551    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9641    3.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7040    1.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2731    2.0878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  6  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005981

>  <SMILES>
O=C(CC1(O)CCC1)N1CCCC2(CCN(c3ccsc3)C2=O)C1

$$$$
SWF005982
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -6.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  6  4  1  1  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF005982

>  <SMILES>
O=C(CC1CC2(CCNCC2)Oc2ccccc21)NC1CC1

$$$$
SWF005983
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5126    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0855    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    3.8083   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.3740   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
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 13 15  1  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005983

>  <SMILES>
O=C(c1ccc[nH]1)N1CCC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF005984
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    1.1444    1.5248   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0546    3.1558   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0546    1.7416   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    3.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2617    1.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6525    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005984

>  <SMILES>
N#Cc1ccc(OC[C@]23COC[C@H]2CN(C(=O)C2(F)CCC2)C3)nc1

$$$$
SWF005985
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9328    1.0657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9546    0.8578   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -2.5115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.0934   -2.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 10  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005985

>  <SMILES>
O=C1N(Cc2cccnc2)c2ccc(F)cc2C12CCNCC2

$$$$
SWF005986
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7853   -3.1970   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  6  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF005986

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1cccnc1

$$$$
SWF005987
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF005987

>  <SMILES>
CCS(=O)(=O)NCC1CCC2(CN(Cc3ccccc3OC)C2)OC1

$$$$
SWF005988
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5549    1.7071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2869    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  1  6  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  2  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF005988

>  <SMILES>
CNC(=O)C1COC2(CN(C(=O)c3cc4ccccc4[nH]3)C2)CN1C

$$$$
SWF005989
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.8894    2.5912   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    8.5280    4.2549   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005989

>  <SMILES>
Cc1nc(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)C2CC2)C3)cs1

$$$$
SWF005990
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  1  0  0  0
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 11 17  1  0  0  0  0
 14 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005990

>  <SMILES>
Cc1ccccc1S(=O)(=O)N1CC(F)(F)CC2(CCNC2=O)C1

$$$$
SWF005991
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    9.0301   -1.2885   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005991

>  <SMILES>
O=C(N[C@H]1C[C@]2(CCN(C(=O)CCc3ccc[nH]3)C2)C1)C1CC1

$$$$
SWF005992
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005992

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2ccccn2)N1Cc1ccccc1

$$$$
SWF005993
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF005993

>  <SMILES>
O=C(N1CCCC2(CCN(c3cccnc3)C2=O)C1)C1(F)CCC1

$$$$
SWF005994
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF005994

>  <SMILES>
Cn1cc(CN2CCC3(CCCC3C(=O)N3CC(F)(F)C3)C2)cn1

$$$$
SWF005995
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 23 26  1  0  0  0  0
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M  END
>  <HTSID>
SWF005995

>  <SMILES>
O=C(c1cnccn1)N1CC[C@@H](OCC2CC2)[C@@H](Cc2ccccc2)C1

$$$$
SWF005996
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005996

>  <SMILES>
Cc1cccc(CN2CCC3(CCc4nnc(C(=O)NC5CC5)n4C3)CC2)c1

$$$$
SWF005997
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 11 10  1  6  0  0  0
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M  END
>  <HTSID>
SWF005997

>  <SMILES>
Cc1noc(C)c1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1cccc(F)c1F

$$$$
SWF005998
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF005998

>  <SMILES>
Cc1ccc(C(=O)N2CC3(C2)C(COCC2CC2)CCS3(=O)=O)cc1

$$$$
SWF005999
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF005999

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CC[C@@H]2CN(C)CCO[C@@H]2C1

$$$$
SWF006000
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5 10  2  0  0  0  0
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 10 14  1  0  0  0  0
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 14 18  2  0  0  0  0
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 16 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 22 24  2  0  0  0  0
  6  9  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006000

>  <SMILES>
O=C(c1cc[nH]c1)N1CCCC2(CCN(c3ccccc3)C2=O)C1

$$$$
SWF006001
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.3953   -2.2452   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4204   -2.4677   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -1.7347   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1257   -3.4233   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7653   -1.9572   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1793   -3.7465   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7255   -4.2234   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3548   -0.0460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0851   -1.2241   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1943   -4.7464   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1499   -5.0411   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4243   -0.5633   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006001

>  <SMILES>
C=CCN1CCOCC2(CCN(C(=O)c3cc[nH]c3)CC2)C1

$$$$
SWF006002
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4817    5.1305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0804    4.1124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8939    5.9395   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4926    4.9214   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3006    6.8531   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 19 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 24  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006002

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(CC(OCC3CCCC3)CS2)C1

$$$$
SWF006003
Actelion Java MolfileCreator 1.0

 30 34  0  0  1  0  0  0  0  0999 V2000
    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5646   -2.2377   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6456    2.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8366    3.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.2556   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3147    2.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8147    3.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7226   -3.3966   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0316   -4.3477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  6  0  0  0
 12 16  1  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  6  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
  9 12  1  0  0  0  0
 13 14  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006003

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N3CCC4(CCOC4)CC3)C2)c1

$$$$
SWF006004
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6346   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4535    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6291   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4480    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0358   -0.6274   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0303   -0.5228   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6181   -1.3318   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8493    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2560    2.1133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2506    2.2178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006004

>  <SMILES>
CN(C)CCN1CCC2(CCN(C(=O)c3cccnc3)CC2)C1=O

$$$$
SWF006005
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006005

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC(=O)N(c4cncnc4)C3)C2)C1

$$$$
SWF006006
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
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 26 29  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006006

>  <SMILES>
Cc1cccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N(C)Cc3ccccc3)C2)c1

$$$$
SWF006007
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 15  1  0  0  0  0
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 28 29  1  0  0  0  0
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 16 19  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006007

>  <SMILES>
COc1ccc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)NCc3ccccc3)C2)cc1

$$$$
SWF006008
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 18 19  1  0  0  0  0
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 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
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M  END
>  <HTSID>
SWF006008

>  <SMILES>
O=C(c1ccccc1)N1CCO[C@@H]2CN(C(=O)c3cc[nH]c3)C[C@@H]2C1

$$$$
SWF006009
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.1710    2.3350   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  4  8  1  0  0  0  0
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  5 10  1  6  0  0  0
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  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006009

>  <SMILES>
CN(C)[C@@H]1CCN(C(=O)c2ccncc2)[C@H]1Cc1cnn(C)c1

$$$$
SWF006010
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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  4  8  1  0  0  0  0
  5  9  1  1  0  0  0
  5 10  1  0  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
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 13 16  1  0  0  0  0
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 18 21  1  0  0  0  0
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  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006010

>  <SMILES>
c1ccc(O[C@@H]2CC[C@H]3[C@H]2OCCN3Cc2cccnc2)nc1

$$$$
SWF006011
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
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 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 22  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006011

>  <SMILES>
CN(C)C(=O)N[C@H]1C[C@@]2(CCN(C(=O)c3cc4ccccc4n3C)C2)C1

$$$$
SWF006012
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  2  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006012

>  <SMILES>
CCN1CCC2(CN(C(=O)c3c[nH]c(C)n3)CC(F)(F)C2)C1=O

$$$$
SWF006013
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
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 11 13  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006013

>  <SMILES>
Cc1ccc(CN2C[C@@H](C)[C@@]3(CCN(CCN(C)C)C3=O)C2)o1

$$$$
SWF006014
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
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 10 12  2  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006014

>  <SMILES>
CNC(=O)N1CCC2(COCc3cnc(-c4ccccc4)nc32)C1

$$$$
SWF006015
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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  7  8  1  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF006015

>  <SMILES>
CN(C)CCOCC1CC2OCCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)C2C1

$$$$
SWF006016
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  6  0  0  0
  8 12  1  6  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  7  8  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <HTSID>
SWF006016

>  <SMILES>
Cc1nnc(N2CCOCC3(CCCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)C3)C2)o1

$$$$
SWF006017
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    6.6967   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7456   -2.7682   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0823   -0.9514   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006017

>  <SMILES>
O=C(c1cc[nH]n1)N1CC2(C1)OCCC2CCOCC1CC1

$$$$
SWF006018
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    0.8660   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
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 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006018

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2cccc(F)c2F)N1Cc1ccccc1

$$$$
SWF006019
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    2.8147   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  8 13  1  0  0  0  0
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 10 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 16 18  2  0  0  0  0
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 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  6  0  0  0
 21 23  1  6  0  0  0
 22 24  1  0  0  0  0
  7 11  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006019

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CC2CCN(c3cccnc3)C(=O)C2C1

$$$$
SWF006020
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7216   10.2324   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 22 24  1  0  0  0  0
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  7  8  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006020

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCCC2(COCCN(c3cccnc3)C2)C1

$$$$
SWF006021
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    8.3615   -3.1728   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4955   -1.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -3.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6295   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634   -2.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7634   -1.6728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7929   -0.1783   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -1.5796   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5360    0.4908   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 13 10  1  6  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006021

>  <SMILES>
O=C1CC2(CCN(C(=O)C3(F)CCC3)C2)CN1c1ccc(F)cc1

$$$$
SWF006022
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    9.0933    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8549    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7336    3.3107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    4.3713   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.8713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006022

>  <SMILES>
c1cncc(COCCC2CCOC3(C2)CN(CC2CC2)C3)c1

$$$$
SWF006023
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006023

>  <SMILES>
O=C(NC1CCCCC1)N1CCC2(CCCN(c3ccccn3)C2)C1

$$$$
SWF006024
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
  9 12  1  0  0  0  0
 15 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006024

>  <SMILES>
O=C(c1ccccc1)N1CC2(CCNCC2)c2cc(F)ccc21

$$$$
SWF006025
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 13 17  1  0  0  0  0
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 15 20  1  0  0  0  0
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 22 23  2  0  0  0  0
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 25 27  2  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006025

>  <SMILES>
C[C@@H]1CN(S(=O)(=O)c2cn(C)cn2)C[C@]12CCN(Cc1cccnc1)C2=O

$$$$
SWF006026
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
   10.3923   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942    3.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0838   -5.0950   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5474   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0035  -10.1776   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
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  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 14 13  1  1  0  0  0
 14 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  6  0  0  0
 18 20  1  6  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  2  0  0  0  0
 27 29  2  0  0  0  0
  6  8  1  0  0  0  0
 17 18  1  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006026

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3cccnc3)CC[C@H]21)NCc1cc(F)cc(F)c1

$$$$
SWF006027
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  1  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  6  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006027

>  <SMILES>
CN(C)C(=O)C[C@@H]1OC[C@H]2CN(Cc3cccnc3)CC[C@H]21

$$$$
SWF006028
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006028

>  <SMILES>
CC(C)CC(=O)N1CCC(Nc2ccn(C)n2)(C(=O)N2CCCC2)CC1

$$$$
SWF006029
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.0935   -7.2221   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1565   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9065   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9065   -7.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5935   -7.2221   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4065   -4.6240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.1565   -5.9231   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  1  0  0  0
 11 15  1  1  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 11  1  0  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006029

>  <SMILES>
CC1(C(=O)N2C[C@@H]3OCCN(Cc4cccnc4)[C@@H]3C2)CC=CCC1

$$$$
SWF006030
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    7.0333   -1.8107   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 15 17  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006030

>  <SMILES>
O=C(C[C@@H]1OC[C@H]2CN(Cc3cccnc3)CC[C@H]21)NC1CS(=O)(=O)C1

$$$$
SWF006031
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    4.8281    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0360   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9871   -0.6842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1950   -1.6624   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7302   -0.0151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8892   -1.3022   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
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  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
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 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006031

>  <SMILES>
Cc1ncnc(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)c1C

$$$$
SWF006032
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    8.4016   -2.5402   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8849   -2.7637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3021   -1.5199   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2895   -4.0360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.6410   -4.6868   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0688   -3.0425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  6  0  0  0
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  6  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
  9 11  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006032

>  <SMILES>
CC(=O)N1CC[C@@H]2NS(=O)(=O)c3ccccc3O[C@H]2CC1

$$$$
SWF006033
Actelion Java MolfileCreator 1.0

 30 33  0  0  1  0  0  0  0  0999 V2000
    8.5851    1.3053   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.0486   -0.1212   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0523    0.9935   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.0409    5.0471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3399    5.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
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 17 21  2  0  0  0  0
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 20 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
 27 29  2  0  0  0  0
 28 30  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 18 21  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <HTSID>
SWF006033

>  <SMILES>
COc1cccc(CN2C[C@H]3CCN(C(=O)Nc4ccccc4)CC[C@H]3S2(=O)=O)c1

$$$$
SWF006034
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6449   -7.3203   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6231   -7.1124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  6  0  0  0
 10 12  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006034

>  <SMILES>
CNC(=O)C[C@@H]1OC[C@H]2CN(Cc3ccc(OC)cc3)CC[C@H]21

$$$$
SWF006035
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -8.8379   -3.1024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006035

>  <SMILES>
O=C(c1csnn1)N1CCC2(CC1)CCN(c1ccsc1)C2=O

$$$$
SWF006036
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7570    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    5.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    5.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    5.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
  7  8  1  0  0  0  0
 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006036

>  <SMILES>
c1ccc(COC2CCOC3(C2)CN(C2CCOCC2)C3)nc1

$$$$
SWF006037
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6629    2.8653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4894   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9577    3.8209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7170    3.9888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2984   -3.2038   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3944    4.6472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3972    4.7219   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0318    5.6528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  6  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006037

>  <SMILES>
CN1CCO[C@@H]2CN(C(=O)c3cc(C4CC4)on3)CC[C@@H]2C1

$$$$
SWF006038
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7431   -1.1691   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2079    0.4781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6581   -1.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6092   -0.3309   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3364   -2.0827   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2024    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2024    2.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2024    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.2024    0.5827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7024    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  2  0  0  0  0
  8  5  1  6  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  2  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006038

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccccn1)C2)c1ccno1

$$$$
SWF006039
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    0.8660   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.4962   -0.4297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3622   -0.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1348    1.2340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3622   -1.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2283   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -2.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2283   -3.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4962   -3.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3622   -4.9297   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  6  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 25 26  1  0  0  0  0
  7  9  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006039

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2cccc(F)c2F)N1Cc1ccc(F)cc1

$$$$
SWF006040
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9996   -2.0792   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.5263    2.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0263    2.7749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0628    4.2015   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4898    4.2015   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.2763    5.0831   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  6  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006040

>  <SMILES>
CN1CC(=O)N(c2ccsc2)CC12CCN(S(=O)(=O)N(C)C)C2

$$$$
SWF006041
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3092   -0.7319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3147   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7929   -1.9103   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006041

>  <SMILES>
CCC1=N[C@@]2(CC[C@@H]3CN(Cc4ccc(C)cc4)C[C@@H]32)C(=O)N1C

$$$$
SWF006042
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.5820    3.0865   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 20 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF006042

>  <SMILES>
c1cc(C[C@H]2[C@@H](OCC3CC3)CCN2Cc2nccs2)ccn1

$$$$
SWF006043
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006043

>  <SMILES>
O=C(c1cc[nH]n1)N1C[C@@H]2OCCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF006044
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006044

>  <SMILES>
CN1Cc2nccn2CC12CCN(C(=O)CCc1ccc[nH]1)C2

$$$$
SWF006045
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006045

>  <SMILES>
O=C(Cc1ccccn1)N1CCC2(CC1)CC(N1CCCC1)C2

$$$$
SWF006046
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006046

>  <SMILES>
O=C(/C=C/c1cccs1)N1CCc2ncnc(NC3CC3)c2CC1

$$$$
SWF006047
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.7788    2.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006047

>  <SMILES>
CCOCC12CCCOC1CCN(C(=O)c1cscn1)C2

$$$$
SWF006048
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    7.4469   -4.6158   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006048

>  <SMILES>
COCC1CCOC12CN(C(=O)c1cc3ccccc3[nH]1)C2

$$$$
SWF006049
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 14 17  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006049

>  <SMILES>
O=C(NCc1cccs1)[C@@]12CCO[C@@H]1CCN(CC1CC1)C2

$$$$
SWF006050
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006050

>  <SMILES>
Cc1ccc(S(=O)(=O)N2CCn3cc(CC(=O)NC4CCC4)nc3C2C)cc1

$$$$
SWF006051
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006051

>  <SMILES>
c1ccc(COCC23CCCOC2CCN(Cc2ccco2)C3)nc1

$$$$
SWF006052
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006052

>  <SMILES>
CO[C@H]1CN(S(=O)(=O)c2cn(C)cn2)[C@@H]2CCCO[C@H]12

$$$$
SWF006053
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006053

>  <SMILES>
O=C(N1CCCO1)[C@@]12CCO[C@@H]1CCN(CCN1CCCCC1)C2

$$$$
SWF006054
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 29 30  1  0  0  0  0
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 16 19  1  0  0  0  0
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 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006054

>  <SMILES>
Cc1nc2c(n1C(C)C)CN(Cc1cnn(C)c1)CC21CCN(C(=O)N(C)C)CC1

$$$$
SWF006055
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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 10 11  2  0  0  0  0
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 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF006055

>  <SMILES>
C[C@H]1C[C@H]2CN(C(=O)CCc3ccc(Cl)cc3)CC[C@H]2O1

$$$$
SWF006056
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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 10 11  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006056

>  <SMILES>
O=C(N1CCCC1)[C@@]12CCO[C@@H]1CCN(Cc1cccnc1)C2

$$$$
SWF006057
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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  5  8  1  0  0  0  0
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 10  6  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006057

>  <SMILES>
Cc1ccc(N2CC[C@H]3C[C@@H](C(=O)NC4CC4)O[C@H]3C2)nn1

$$$$
SWF006058
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    1.1340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 12  1  0  0  0  0
 10 11  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006058

>  <SMILES>
O=C(CC1CC1)N1CCC2OCCCC2(COCc2cccnc2)C1

$$$$
SWF006059
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    8.6446    1.5613   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7629    0.3478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9847    3.2302   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.4749   -2.5496   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
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  4  8  1  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  1  1  0  0  0
 12 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  9 11  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006059

>  <SMILES>
O=C(c1cccnc1)N1C[C@@H](OCC2CC2)[C@H]2OCCC[C@H]21

$$$$
SWF006060
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.1083    3.9290   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.7893    5.2655   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3221    5.5773   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5921    2.7945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
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  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006060

>  <SMILES>
COc1ccc(CN2C(=O)CCC23CCN(C(=O)C2(F)CC2)CC3)cc1

$$$$
SWF006061
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.6665    4.0468   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1665    3.1808   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6665    2.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    2.3147   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1665    1.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6665    0.5827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006061

>  <SMILES>
Fc1cnc(N2C[C@H]3CCC[C@@]3(COCc3ccncc3)C2)nc1

$$$$
SWF006062
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    7.1808    2.0685   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808   -0.5296   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.7934   -1.1088   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 13  1  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 13 10  1  1  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006062

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@H]2CCN(C(=O)c3cnccn3)C[C@@H]2C1

$$$$
SWF006063
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 18 20  1  0  0  0  0
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M  END
>  <HTSID>
SWF006063

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(C2)Cn2ccnc2CN3C)cn1

$$$$
SWF006064
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006064

>  <SMILES>
CC1CC(C(=O)N2CCC3(CCC(=O)N3Cc3ccncc3)CC2)C1

$$$$
SWF006065
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 14 16  1  6  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006065

>  <SMILES>
Cc1cc(CN2C[C@@H]3[C@H](CNC(=O)c4cnccn4)CO[C@@H]3C2)no1

$$$$
SWF006066
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006066

>  <SMILES>
CN1CC(=O)N(c2cnn(C)c2)CC12CCN(C(=O)/C=C/c1cccs1)C2

$$$$
SWF006067
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006067

>  <SMILES>
COc1ccc(CC(=O)N2CC3(CC(Oc4ccccn4)CCO3)C2)cc1

$$$$
SWF006068
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.2318    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8141    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6915    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2205    2.3683   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9973    2.0238   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  9 13  1  1  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 21 23  1  0  0  0  0
  8 12  1  0  0  0  0
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006068

>  <SMILES>
COCCO[C@@H]1CCN(C(=O)C2CCC2)[C@H]1Cc1ccccc1

$$$$
SWF006069
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006069

>  <SMILES>
CN(C)C(=O)NC1CCOC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF006070
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.7938   -3.3010   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1758   -3.3010   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  1  0  0  0
 16 17  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF006070

>  <SMILES>
CC(=O)N1CC(=O)N(c2ccsc2)CC12CCN(C(=O)c1ccc(C)o1)C2

$$$$
SWF006071
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.7549   -3.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.8322   -5.4240   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  2  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006071

>  <SMILES>
Cc1cccc(F)c1C(=O)N1CCC2(CC1)CC(=O)N(C)C2

$$$$
SWF006072
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  6  1  0  0  0  0
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  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006072

>  <SMILES>
COCCN1CCCC2(CCN(C(=O)c3cc[nH]n3)CC2)C1=O

$$$$
SWF006073
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7570    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.9142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    3.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4935    5.4087   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  1  0  0  0  0
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  7  8  1  0  0  0  0
 19 20  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006073

>  <SMILES>
Cc1cncc(COC2CCOC3(C2)CN(Cc2ccco2)C3)c1

$$$$
SWF006074
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.8995   -2.2377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  7  1  0  0  0  0
  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006074

>  <SMILES>
c1cncc(COCC2CCC3C2OCCN3CC2CC2)c1

$$$$
SWF006075
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 14 12  1  1  0  0  0
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 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006075

>  <SMILES>
CN1CCC2(CN(C(=O)c3cccc(F)c3)CC(F)(F)C2)C1=O

$$$$
SWF006076
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 24 26  1  0  0  0  0
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 12 15  1  0  0  0  0
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 22 23  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006076

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCC2(CCC(=O)N2Cc2cccnc2)CC1

$$$$
SWF006077
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.7050    0.3907   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006077

>  <SMILES>
c1ccc(CN2CCC3(CCN(c4ncccn4)CC3)C2)nc1

$$$$
SWF006078
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006078

>  <SMILES>
O=C(N1CCC2(CC1)CN(Cc1nccs1)CCO2)C1(F)CC1

$$$$
SWF006079
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0926    2.4343   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  2  0  0  0  0
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 13 16  1  0  0  0  0
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 16 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006079

>  <SMILES>
COCC(=O)N1CCC2(COCc3cnc(-c4ccccc4)nc32)C1

$$$$
SWF006080
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.1226    3.2251   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4535    2.4820   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0362    2.8184   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9317    1.8239   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.8255    1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
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 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006080

>  <SMILES>
O=C(N1CCCC2(CCN(c3ccsc3)C2=O)C1)C1(F)CC1

$$$$
SWF006081
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0999    0.7412   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    1.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -3.7071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.3587   -6.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
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 20 23  1  0  0  0  0
  4  5  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006081

>  <SMILES>
Cc1cncc(OC2CCOC3(C2)CN(C(=O)C2(F)CC2)C3)n1

$$$$
SWF006082
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    7.7942    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5442    5.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0442    5.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006082

>  <SMILES>
CCS(=O)(=O)N1CCC(Nc2ccccc2)(C(=O)NC(C)C)CC1

$$$$
SWF006083
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006083

>  <SMILES>
Cc1cccc(CN2CCC(Nc3nccs3)(C(=O)NC3CC3)CC2)c1

$$$$
SWF006084
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    6.9282    4.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006084

>  <SMILES>
CC(C)C(=O)N1CCC(Nc2cccc(F)c2)(C(=O)N(C)C)CC1

$$$$
SWF006085
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    4.1341    3.7830   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6209    3.7830   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6209    2.2698   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4851   -0.4901   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
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  9 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006085

>  <SMILES>
O=C(NCC(F)(F)F)C1(n2ccnc2)CCN(Cc2ccccc2)CC1

$$$$
SWF006086
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.6095    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6225   -0.7570   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9337    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0719   -2.1299   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006086

>  <SMILES>
Cc1ccccc1CN1CCC(C(=O)N(C)C)(n2cccn2)CC1

$$$$
SWF006087
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.1962    3.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.6961    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 12  1  1  0  0  0
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 13 17  1  1  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006087

>  <SMILES>
O=C(Nc1cccnc1)[C@H]1CN(S(=O)(=O)C2CC2)C[C@H]2OCC[C@@H]12

$$$$
SWF006088
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.9273    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.7364    0.3004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006088

>  <SMILES>
Cc1ccc(CC(=O)N2CC3(CC(Oc4cccnc4)CS3)C2)cc1

$$$$
SWF006089
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    7.7942   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7087    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 18 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF006089

>  <SMILES>
O=C([C@@H]1C[C@H]2OCC[C@H]2N(C(=O)[C@H]2[C@@H]3COC[C@@H]32)C1)N1CCCC1

$$$$
SWF006090
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    4.1402    3.7885   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6248    3.7885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1094    3.7885   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6248    2.2731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006090

>  <SMILES>
CCC(=O)N1CCCC(C(=O)NCC(F)(F)F)(n2ccnc2)C1

$$$$
SWF006091
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.2258    0.1012   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 17  1  0  0  0  0
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 14 20  1  0  0  0  0
 16 21  1  0  0  0  0
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 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 10 15  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006091

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)c1nc3ccccn3c1C)C2

$$$$
SWF006092
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
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M  END
>  <HTSID>
SWF006092

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C2CC(F)(F)C2)C1

$$$$
SWF006093
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 13 15  1  6  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006093

>  <SMILES>
O=C(C1CC1)N1CCO[C@H]2[C@@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF006094
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    9.2059   -2.1409   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
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 21 22  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF006094

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)COC)C1

$$$$
SWF006095
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    1.7443    1.0967   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5879    2.0844   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9008    0.1090   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7320    1.2531   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7566    0.9402   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4391    0.5460   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1860    2.1441   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1737    1.9877   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2211    0.5460   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0598    1.0906   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0075    2.0893   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7938    3.6325   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7371    2.1799   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  6  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
  8  9  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006095

>  <SMILES>
COCCNC(=O)C1(Nc2cccc(F)c2)CCN(S(C)(=O)=O)C1

$$$$
SWF006096
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006096

>  <SMILES>
Cc1ccccc1CN1CCC(Nc2ccccc2)(C(=O)N(C)C)CC1

$$$$
SWF006097
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    6.9282    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5263   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006097

>  <SMILES>
CCOCC(=O)N1CCC(Nc2ccccc2)(C(=O)NC(C)C)CC1

$$$$
SWF006098
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0435    1.7809   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    3.7855   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5567    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5567    4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    0.7571   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2454    2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.0263   -0.7488   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.3193    1.2396   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340    1.5142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2454   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2454    6.8139   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340    4.5426   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2646    0.2477   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9340   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6227   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6227   -2.2713   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3113   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7571   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  2  0  0  0  0
 13 19  1  0  0  0  0
 15 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006098

>  <SMILES>
CCC(=O)N1CCC(C(=O)Nc2ccccc2)(n2cccn2)CC1

$$$$
SWF006099
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   -0.9135   -1.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -2.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006099

>  <SMILES>
Cc1ccccc1CN1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF006100
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    6.7346    2.6853   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 25  2  0  0  0  0
 23 26  2  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 22 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006100

>  <SMILES>
O=C(c1ccnnc1)N1CC2(C1)C(COc1ccccn1)CCS2(=O)=O

$$$$
SWF006101
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.3792   -2.0283   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8792   -1.1623   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  7  9  1  0  0  0  0
 10 12  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006101

>  <SMILES>
COc1ncccc1CN1CCOC[C@]2(CN(C)C[C@H]2C)C1

$$$$
SWF006102
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    3.8792   -1.1623   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3792   -2.0283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006102

>  <SMILES>
c1cncc(CN2CCO[C@@H]3CN(C4CCOCC4)C[C@@H]3C2)c1

$$$$
SWF006103
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 21 23  1  0  0  0  0
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 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006103

>  <SMILES>
COCC1CN(S(C)(=O)=O)CC12CCN(C1CCOCC1)CC2

$$$$
SWF006104
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 23  2  0  0  0  0
 20 24  1  0  0  0  0
 22 25  2  0  0  0  0
  4  7  1  0  0  0  0
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 19 21  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006104

>  <SMILES>
CCc1oncc1C(=O)N1CC2(CC(OCc3cccnc3)CS2)C1

$$$$
SWF006105
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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   -3.9830   -3.1615   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7965   -1.3345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  1  5  1  0  0  0  0
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  9 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 15  2  0  0  0  0
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 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006105

>  <SMILES>
CC1(C(=O)N2CC[C@]3(C2)C[C@H](NS(C)(=O)=O)C3)CC=CCC1

$$$$
SWF006106
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  1  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006106

>  <SMILES>
O=C(NCC1CN(C2CCCC2)Cc2ccnn21)N1CCCC1

$$$$
SWF006107
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.4520    2.4310   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8401    1.0567   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  2  0  0  0  0
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 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
  5  7  1  0  0  0  0
 12 14  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006107

>  <SMILES>
CC[C@@H]1N(C(=O)c2ccoc2C)CCC[C@]12CCC(=O)N2C

$$$$
SWF006108
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF006108

>  <SMILES>
Cc1cccc(CN2CCC3(CCN(C(=O)C4CC(O)C4)CC3)C2=O)c1

$$$$
SWF006109
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 13 16  1  0  0  0  0
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 22 23  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006109

>  <SMILES>
CC1(C)CC1C(=O)N1CCCC2(CCCN(CC(=O)N3CCCC3)C2)C1

$$$$
SWF006110
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006110

>  <SMILES>
COCC12CCCOC1CCN(C(=O)c1csc(C)n1)C2

$$$$
SWF006111
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.6345    0.5759   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424    1.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5366    1.1939   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.4877    1.5029   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  7 10  1  0  0  0  0
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 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF006111

>  <SMILES>
Cc1ccc(CN2CCO[C@@]3(CCC[C@@H]3COC(C)C)C2)o1

$$$$
SWF006112
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006112

>  <SMILES>
c1ccc(OC2CCOC3(C2)CN(Cc2nccs2)C3)nc1

$$$$
SWF006113
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.9546    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006113

>  <SMILES>
c1ccc(CN2CCO[C@H]3[C@H](Oc4cccnc4)CC[C@@H]32)nc1

$$$$
SWF006114
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 12 13  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006114

>  <SMILES>
CN(C)C(=O)CO[C@@H]1CC[C@H]2[C@H]1OCCN2c1ncccn1

$$$$
SWF006115
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 20 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006115

>  <SMILES>
COCc1ccc(C(=O)N2CCC(C3CCCCN3C)CC2)cc1

$$$$
SWF006116
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  7  1  6  0  0  0
  8 11  1  0  0  0  0
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 10 14  1  0  0  0  0
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 10 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006116

>  <SMILES>
CC(C)N1CC[C@H]2C[C@H](C(=O)N(C)Cc3ccccn3)O[C@H]2C1

$$$$
SWF006117
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    7.8152    2.2561   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.5127    1.5040   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9076    1.5040   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 17 21  1  0  0  0  0
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 21 24  2  0  0  0  0
  6  7  1  0  0  0  0
 16 18  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006117

>  <SMILES>
CC[C@H]1N(C(=O)Cc2ccc(F)cn2)CCC[C@]12CCC(=O)N2C

$$$$
SWF006118
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.5078   -3.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
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  6 10  1  0  0  0  0
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  8 12  2  0  0  0  0
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 10 15  1  1  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 20 21  1  0  0  0  0
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 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
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 14 16  1  0  0  0  0
 17 18  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006118

>  <SMILES>
O=C(NCc1ccccc1)C1CN(C(=O)c2cc[nH]n2)Cc2ncnn2C1

$$$$
SWF006119
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
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 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
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 18 20  2  0  0  0  0
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 21 23  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006119

>  <SMILES>
CCOCC1CN(Cc2cccc(OC)c2)Cc2nccn2C1

$$$$
SWF006120
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  2  0  0  0  0
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 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006120

>  <SMILES>
O=S(=O)(C1CC1)N1CCn2c(COCc3cccnc3)nnc2C1

$$$$
SWF006121
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006121

>  <SMILES>
O=C(c1ccccc1)N1C[C@H]2CN(CC3CCCO3)CC[C@H]2C1

$$$$
SWF006122
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
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 12 13  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006122

>  <SMILES>
CNC(=O)c1cnc2n1CCN(Cc1cccc(OC)c1)C2

$$$$
SWF006123
Actelion Java MolfileCreator 1.0

 28 30  0  0  1  0  0  0  0  0999 V2000
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 26 28  1  0  0  0  0
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M  END
>  <HTSID>
SWF006123

>  <SMILES>
COc1cccc(NC(=O)N2CC[C@@H]3CN(CCC(C)C)S(=O)(=O)[C@@H]3CC2)c1

$$$$
SWF006124
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 23 24  3  0  0  0  0
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M  END
>  <HTSID>
SWF006124

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)C(=O)N(CC#N)CCN3C)cs1

$$$$
SWF006125
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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 25 27  1  0  0  0  0
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M  END
>  <HTSID>
SWF006125

>  <SMILES>
CCN(CC)C(=O)CC1CC2(CCN(C(=O)N(C)C)CC2)c2ccccc21

$$$$
SWF006126
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 11 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  6  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 12  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006126

>  <SMILES>
O=C(CCc1ccc[nH]1)N1CCO[C@H]2[C@@H](Oc3ccccn3)CC[C@@H]21

$$$$
SWF006127
Actelion Java MolfileCreator 1.0

 32 35  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006127

>  <SMILES>
CC(C)NC(=O)CN1Cc2ccccc2CC2(CCN(C(=O)C3CCCCC3)CC2)C1=O

$$$$
SWF006128
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.3716   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -0.6285   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006128

>  <SMILES>
Cn1cnc(C(=O)N2CCO[C@H]3[C@@H](Oc4ccccn4)CC[C@@H]32)n1

$$$$
SWF006129
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 18 20  2  0  0  0  0
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  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006129

>  <SMILES>
O=S(=O)(C1CC1)N1CCO[C@H]2C(Cn3cccn3)CC[C@@H]21

$$$$
SWF006130
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    0.7617    2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7617    2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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M  END
>  <HTSID>
SWF006130

>  <SMILES>
O=C(c1cc(C2CC2)on1)N1C[C@H]2CCC[C@@]2(COc2ccccn2)C1

$$$$
SWF006131
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.5702   -1.2546   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006131

>  <SMILES>
COCCC1CCOC12CCN(Cc1ccccc1C)CC2

$$$$
SWF006132
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
 12 10  1  1  0  0  0
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 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006132

>  <SMILES>
O=C1[C@H]2CN(C(=O)C3(F)CCC3)C[C@H]2CN1c1ccccc1

$$$$
SWF006133
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  6  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
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 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006133

>  <SMILES>
Cc1cc(=O)n2c(n1)CCC1(CCN(C(=O)c3csnn3)C1)CC2

$$$$
SWF006134
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    7.4519    3.5421   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.7637    2.0749   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  6  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
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 12 13  1  0  0  0  0
 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF006134

>  <SMILES>
O=S(=O)(C1CC1)N1CCO[C@H]2[C@H](OCc3ccccn3)CC[C@@H]21

$$$$
SWF006135
Actelion Java MolfileCreator 1.0

 23 27  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  6  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  7  8  1  0  0  0  0
 14 10  1  1  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006135

>  <SMILES>
Cc1nc([C@H]2C[C@@H]3CCN(C(=O)C4[C@H]5COC[C@@H]45)C[C@H]3O2)no1

$$$$
SWF006136
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 15 19  1  0  0  0  0
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 17 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 18 19  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006136

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(Cc2ccco2)C3)n1

$$$$
SWF006137
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.6316    1.7228   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF006137

>  <SMILES>
Cc1ccc(C(=O)N2CCO[C@H]3[C@@H](OCC4CC4)CC[C@@H]32)s1

$$$$
SWF006138
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 27 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006138

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)c4ncnc(C)c4C)CC3)CC2=O)cc1

$$$$
SWF006139
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.3429    3.8358   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  1  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF006139

>  <SMILES>
Fc1cnc(N2CCCC3(CCN(Cc4ccco4)C3)C2)nc1

$$$$
SWF006140
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
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 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006140

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CC1)C(=O)NCCN2CC1CC1

$$$$
SWF006141
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 16 18  1  0  0  0  0
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 23 26  2  0  0  0  0
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 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006141

>  <SMILES>
COc1cccc(NC2COC3(CCN(Cc4ccc(F)cc4)CC3)C2)c1

$$$$
SWF006142
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006142

>  <SMILES>
CC(c1ccccc1)N1C(=O)C[C@H]2[C@@H]1CCN2Cc1cccc(F)c1F

$$$$
SWF006143
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006143

>  <SMILES>
Cc1nc(COC2CSC3(C2)CN(S(=O)(=O)c2cccnc2)C3)cs1

$$$$
SWF006144
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006144

>  <SMILES>
Cn1cc(CN2CC3(C2)OCCC3CCOc2ccccn2)cn1

$$$$
SWF006145
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006145

>  <SMILES>
CCOCC1COCCC12CCN(Cc1ccccc1OC)CC2

$$$$
SWF006146
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006146

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(NC(=O)N(C)C)C3)C1

$$$$
SWF006147
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    7.4262   -1.1030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006147

>  <SMILES>
CC(C)N(C)CC(=O)N1C[C@@H]2C(C(=O)N3CCCC3)=NO[C@@H]2C1

$$$$
SWF006148
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF006148

>  <SMILES>
CN(Cc1ccccn1)C1CC2(CCN(Cc3cccnc3)CC2)C1

$$$$
SWF006149
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
  9 11  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006149

>  <SMILES>
O=C(CC1(O)CCC1)N1C2CCC1CN(Cc1cccnc1)C2

$$$$
SWF006150
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 23 24  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006150

>  <SMILES>
CC1CC(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)c2ccncc2)C3)C1

$$$$
SWF006151
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.9838   -4.0358   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9824   -4.0881   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  5  1  0  0  0  0
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 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006151

>  <SMILES>
O=C(N1CC2(C1)OCCC2CCOc1ccccn1)C1(F)CC1

$$$$
SWF006152
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.6665    2.3147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006152

>  <SMILES>
O=C(N1CCCC1)N1C[C@H]2CCC[C@@]2(COCc2ccccn2)C1

$$$$
SWF006153
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 10 14  2  0  0  0  0
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 11 16  1  0  0  0  0
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 18 22  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF006153

>  <SMILES>
Cc1ncoc1C(=O)N1CC(F)(F)CC2(CCN(C)C2=O)C1

$$$$
SWF006154
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.8235   -2.8009   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7745   -3.1099   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5177   -2.4408   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5163   -2.4932   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.5468   -1.7024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  7 10  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  8  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006154

>  <SMILES>
O=C(CC1CC1)N1CC2(C1)OCCC2CCOc1ccccn1

$$$$
SWF006155
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 20 22  2  0  0  0  0
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 21 24  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006155

>  <SMILES>
Cc1cc(C)nc(N2CC[C@H]3[C@@H]2CC(=O)N3Cc2ccccc2)n1

$$$$
SWF006156
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.9282   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  6  1  0  0  0  0
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 10 15  1  0  0  0  0
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 13 18  1  0  0  0  0
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 16 21  1  0  0  0  0
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 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
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 22 26  1  0  0  0  0
  9 12  1  0  0  0  0
 15 16  2  0  0  0  0
 17 18  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006156

>  <SMILES>
CN(C)CCC1CN(C(=O)CC2Cc3ccccc3C2)Cc2ccnn21

$$$$
SWF006157
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
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   10.2093    2.0697   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
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 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
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 14 15  1  0  0  0  0
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M  END
>  <HTSID>
SWF006157

>  <SMILES>
COCc1ccc(C(=O)N2CC[C@@H]3[C@@H](CC2)OCCN3S(C)(=O)=O)cc1

$$$$
SWF006158
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0668  -11.9829   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4372  -11.3728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006158

>  <SMILES>
O=C(Cc1cccnc1)N1CCC2(CCN(CC3CCOC3)CC2)C1

$$$$
SWF006159
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  1  0  0  0  0
  5  8  2  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  1  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006159

>  <SMILES>
CN1CC(=O)N(c2cccc(F)c2)CC12CCN(C(=O)c1ccoc1)C2

$$$$
SWF006160
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6109   -4.4672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7128   -3.2537   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  1  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006160

>  <SMILES>
C1CC(CN2CC[C@@H]3O[C@@H](c4nnc(C5CC5)o4)C[C@H]3C2)CCO1

$$$$
SWF006161
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -3.9684   -4.3601   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -3.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -2.2582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6402   -1.2545   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006161

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2sccc2C)CC1

$$$$
SWF006162
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
   13.0617    3.6101   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   11.6913    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.7334    0.5045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5231    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006162

>  <SMILES>
COCCNC(=O)C1(Nc2nccs2)CCN(Cc2scnc2C)CC1

$$$$
SWF006163
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
 13 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006163

>  <SMILES>
CCC(=O)N1CCC(Nc2ccccc2)(C(=O)NC(C)C)CC1

$$$$
SWF006164
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   -6.4952   -1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.8971   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2990   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 20 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
 25 27  2  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006164

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccc(F)cc2)CC1

$$$$
SWF006165
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.8900    4.1521   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF006165

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)C(C)C)C1

$$$$
SWF006166
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 24  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006166

>  <SMILES>
Cc1ccccc1CNC1CCc2onc(C(=O)NC(C)C)c2C1

$$$$
SWF006167
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
    4.3179   -1.5967   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 18 20  1  0  0  0  0
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 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006167

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(S(C)(=O)=O)C1

$$$$
SWF006168
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.4859   -0.4902   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3812    2.5840   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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  6 10  1  0  0  0  0
 14 17  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006168

>  <SMILES>
O=C(N1CCC1)C1(n2cccn2)CCN(Cc2ccccc2)CC1

$$$$
SWF006169
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
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 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006169

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(Cc2cccnc2)CC1

$$$$
SWF006170
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  2  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
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 22 23  2  0  0  0  0
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 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
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 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006170

>  <SMILES>
CC(C)c1snnc1C(=O)NC1CC2(CCN(Cc3cccnc3)CC2)C1

$$$$
SWF006171
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 14  1  0  0  0  0
 23 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006171

>  <SMILES>
O=C(N1CCC1)C1(Nc2ccccc2)CCN(Cc2ccccc2Cl)CC1

$$$$
SWF006172
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    1.3202   -2.6730   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
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 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006172

>  <SMILES>
C[C@@H]1CN(Cc2ccoc2)C[C@]12CCN(c1cccnc1)C2=O

$$$$
SWF006173
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    5.5340   -1.4390   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 14  2  0  0  0  0
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 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  2  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006173

>  <SMILES>
CC1(C(=O)N2CC3(CCN(S(C)(=O)=O)C3)C2)CC=CCC1

$$$$
SWF006174
Actelion Java MolfileCreator 1.0

 20 23  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    8.9111   -0.7882   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
  7 10  1  0  0  0  0
  8  9  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006174

>  <SMILES>
O=S(=O)(C1CC1)N1CC2(CC(CO)CN2CC2CC2)C1

$$$$
SWF006175
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.2401   -0.7563   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5615   -0.7720   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5501    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601   -2.2690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601    0.7563   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2401    0.7563   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 12 17  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 23 26  2  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006175

>  <SMILES>
COCCNC(=O)C1(n2cccn2)CCN(Cc2ccccc2C)CC1

$$$$
SWF006176
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    5.1808    3.8005   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    2.0685   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6808    2.9345   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    2.0685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  6  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 14 10  1  1  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006176

>  <SMILES>
CNC(=O)[C@H]1C[C@@H]2CCN(C(=O)c3ccc(C)nc3)C[C@@H]2O1

$$$$
SWF006177
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 10 15  2  0  0  0  0
 11 16  2  0  0  0  0
 11 17  1  0  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  2  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 13 18  1  0  0  0  0
 14 15  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006177

>  <SMILES>
CCC(=O)N1CCC(Nc2ccccc2)(C(=O)Nc2ccn(C)n2)CC1

$$$$
SWF006178
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006178

>  <SMILES>
Cc1cccc(CN2CCCC3(CCN(c4ccccc4)C3)C2)n1

$$$$
SWF006179
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006179

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC2)CC(N(C)C)CO3)cn1

$$$$
SWF006180
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 22 24  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006180

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCC2(CC1)COCCN(c1cccnc1)C2

$$$$
SWF006181
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2437   -0.4067   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 27 28  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF006181

>  <SMILES>
Cc1cc(CN2CC[C@@H]3[C@@H](CO[C@H]3CC(=O)N(C)Cc3ccccc3)C2)[nH]n1

$$$$
SWF006182
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.9193   -2.6970   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  1  0  0  0  0
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  5  8  1  0  0  0  0
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 10 14  1  0  0  0  0
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 13 16  2  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006182

>  <SMILES>
Cc1ccc(N2CC[C@H]3[C@@H]2CC(=O)N3Cc2ccccc2)nn1

$$$$
SWF006183
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
   -1.7591    1.9662   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1713    2.7752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
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 13 11  1  6  0  0  0
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 13 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  7 10  1  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006183

>  <SMILES>
CNC(=O)[C@H]1CCC[C@]12CCN(C(=O)c1ccccc1F)C2

$$$$
SWF006184
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1621    2.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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  9 12  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006184

>  <SMILES>
O=C(C1CC(O)C1)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF006185
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3931    4.6744   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006185

>  <SMILES>
COCCN1CC[C@]2(CN(Cc3cccnc3)C[C@H]2C)C1=O

$$$$
SWF006186
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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  2  1  1  1  0  0  0
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  3  6  2  0  0  0  0
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  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
  5 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 18  2  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
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 22 26  2  0  0  0  0
 24 27  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006186

>  <SMILES>
COc1cccc(CN2C[C@@]3(F)CN(Cc4ccccc4)C[C@@]3(F)C2=O)c1

$$$$
SWF006187
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.1343   -5.9795   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 15 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006187

>  <SMILES>
O=C(NCC1CC1)c1ccc2n1CCN(C(=O)c1cccs1)CC2

$$$$
SWF006188
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006188

>  <SMILES>
CC1(C(=O)N2CCC3(CC2)CCN(c2cncnc2)C3=O)CC=CCC1

$$$$
SWF006189
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 15  2  0  0  0  0
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 13 17  1  6  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006189

>  <SMILES>
CNC(=O)[C@H]1CCC[C@]12CCN(C(=O)c1cncc(C)c1)C2

$$$$
SWF006190
Actelion Java MolfileCreator 1.0

 24 28  0  0  1  0  0  0  0  0999 V2000
    6.2711    0.5046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006190

>  <SMILES>
O=C(N[C@H]1C[C@@]2(CCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)C2)C1)c1cscn1

$$$$
SWF006191
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006191

>  <SMILES>
CS(=O)(=O)N[C@@H]1CCN(C2CCOC2)[C@H]1Cc1ccncc1

$$$$
SWF006192
Actelion Java MolfileCreator 1.0

 20 22  0  0  1  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006192

>  <SMILES>
C[C@H]1C[C@H]2CN(S(=O)(=O)c3ccccc3Cl)CC[C@@H]2O1

$$$$
SWF006193
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006193

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CCN(Cc4nccs4)C3)CC2)n1

$$$$
SWF006194
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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M  END
>  <HTSID>
SWF006194

>  <SMILES>
Cc1cnc(N2CCC3(CCCN(Cc4nccs4)C3)C2)nc1

$$$$
SWF006195
Actelion Java MolfileCreator 1.0

 31 35  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
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 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
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 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 21 24  1  0  0  0  0
 22 23  2  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <HTSID>
SWF006195

>  <SMILES>
O=C(NCC1CC1)c1nnc2n1CCCC21CCN(C(=O)Cn2ccccc2=O)CC1

$$$$
SWF006196
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
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  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  5  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006196

>  <SMILES>
O=C(NCc1noc2c1CC(NCC1CCOCC1)CC2)C1CC(F)(F)C1

$$$$
SWF006197
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   11.8035    1.5144   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 13 18  1  0  0  0  0
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 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006197

>  <SMILES>
COCCC(=O)N1CCC(C(=O)NCC2CC2)(n2cccn2)CC1

$$$$
SWF006198
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
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 20 23  1  0  0  0  0
 20 24  1  0  0  0  0
 10 13  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006198

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2ccn(C)n2)CC1

$$$$
SWF006199
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.0046   -0.1412   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  2  5  2  0  0  0  0
  3  6  2  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 22 24  1  0  0  0  0
  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006199

>  <SMILES>
O=C(c1cccs1)N1CCC(C(=O)N2CCC2)(n2cccn2)CC1

$$$$
SWF006200
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006200

>  <SMILES>
N#CC1(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)c2ccncc2)C3)CCCC1

$$$$
SWF006201
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    2.6456   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  6  0  0  0
 11  9  1  6  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006201

>  <SMILES>
O=C(c1cscn1)N1C[C@H]2CN(Cc3nccs3)C[C@H]2C1

$$$$
SWF006202
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006202

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3cc(OC)no3)CC2)CC1=O

$$$$
SWF006203
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    5.6024   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006203

>  <SMILES>
CSCC(=O)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF006204
Actelion Java MolfileCreator 1.0

 19 21  0  0  0  0  0  0  0  0999 V2000
    5.5340   -1.4390   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006204

>  <SMILES>
CS(=O)(=O)N1CCC2(CN(C(=O)c3csnn3)C2)C1

$$$$
SWF006205
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  3  1  0  0  0  0
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 10  9  1  1  0  0  0
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 10 12  1  0  0  0  0
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 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 12 14  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006205

>  <SMILES>
Cc1nc(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)cs1

$$$$
SWF006206
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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    6.7508   -1.6138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4692   -7.0026   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006206

>  <SMILES>
O=C(C1=CCCC1)N1CCC2(CC1)OCCC2CCOCc1cccnc1

$$$$
SWF006207
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    9.5738   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2429   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  1  0  0  0
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 21 22  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006207

>  <SMILES>
COCCNC(=O)[C@H]1CN(Cc2nccs2)C[C@H]2OCC[C@@H]12

$$$$
SWF006208
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 16 18  1  0  0  0  0
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 22 24  2  0  0  0  0
 10 11  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006208

>  <SMILES>
O=C(CCF)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF006209
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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 21 23  2  0  0  0  0
 23 24  1  0  0  0  0
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 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006209

>  <SMILES>
O=C(c1ccsc1)N1CCCC2(CCN(c3ncc(F)cn3)C2)C1

$$$$
SWF006210
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 16 18  1  0  0  0  0
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 21 22  1  0  0  0  0
 10  9  1  1  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006210

>  <SMILES>
CC1CCC(C(=O)N2C[C@@H]3C(C(=O)N(C)C)=NO[C@@H]3C2)CC1

$$$$
SWF006211
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8 12  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006211

>  <SMILES>
CCO[C@H]1CCN(C(=O)C2CC(C)C2)[C@H]1Cc1cccnc1

$$$$
SWF006212
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3839    5.1680   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  5  8  1  0  0  0  0
  7  9  1  1  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 19 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006212

>  <SMILES>
Cc1cccc(COC2CSC3(C2)CN(C(=O)c2cc[nH]n2)C3)n1

$$$$
SWF006213
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6143    1.5608   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    2.1360   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2560    2.4944   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6627    3.4079   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6572    3.5125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0749    4.2169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4817    5.1305   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0804    4.1124   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006213

>  <SMILES>
O=C(c1cnccn1)N1CC2(CC(OCc3ccccn3)CS2)C1

$$$$
SWF006214
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739    0.9781   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
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  4  6  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006214

>  <SMILES>
CS(=O)(=O)NCC1CN(C(=O)C2=CCCCC2)Cc2ccnn21

$$$$
SWF006215
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.6747   -4.3761   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3657   -3.4250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8657   -4.9638   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3657   -3.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9535   -2.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0567   -4.3761   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1057   -4.6851   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603   -0.4297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8776    0.7728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8558    0.5649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
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  6  8  1  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <HTSID>
SWF006215

>  <SMILES>
Cc1csc(CN2C[C@H](C(=O)NC(C)C)[C@H]3OCC[C@H]32)n1

$$$$
SWF006216
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    0.0668    1.8542   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4732    3.0019   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4560    2.9008   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1470    1.9498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6811    3.9801   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1674    2.6418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5820   -0.6817   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  6  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006216

>  <SMILES>
COCC1CN(C(C)=O)CC12CCN(C(=O)C1(F)CC1)CC2

$$$$
SWF006217
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0613   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6980   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9909   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0395   -2.4095   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462   -3.3231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4407   -3.4276   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8475   -4.3412   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8420   -4.4457   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4298   -3.6367   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 18 21  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 16 17  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006217

>  <SMILES>
CC1CC1C(=O)N1CC2(CC(Oc3ccccn3)CS2)C1

$$$$
SWF006218
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    2.5981    2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  6  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006218

>  <SMILES>
COCC1CN(CC(C)C)CC12CCN(C(=O)Cc1ccccc1F)CC2

$$$$
SWF006219
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000    3.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006219

>  <SMILES>
Cc1cnc2n1CCN(C)C21CCN(C(=O)c2cccnc2)CC1

$$$$
SWF006220
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
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  8 11  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  1  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006220

>  <SMILES>
Cn1ccc(C(=O)N2CC3(C2)OCCC3CCOCc2ccncc2)n1

$$$$
SWF006221
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    3.8301    0.8660   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  6  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  2  0  0  0  0
  9 10  1  0  0  0  0
 15 17  1  0  0  0  0
 18 19  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006221

>  <SMILES>
Cc1ccccc1CN1C(=O)C[C@H]2[C@@H]1CCN2Cc1cccc(C(F)(F)F)c1

$$$$
SWF006222
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    6.4952  -10.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006222

>  <SMILES>
CN(C)C(=O)NC1CCOC2(CCN(Cc3ccccc3F)CC2)C1

$$$$
SWF006223
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    0.8660   -2.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 10  1  6  0  0  0
 10 12  1  0  0  0  0
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 13 16  1  6  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 23 25  1  0  0  0  0
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 13 15  1  0  0  0  0
 16 17  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006223

>  <SMILES>
O=C1C[C@H]2[C@H](CCN2Cc2cccc(F)c2F)N1Cc1cc(F)cc(F)c1

$$$$
SWF006224
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5731    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  6  0  0  0
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 16 18  1  0  0  0  0
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 11 13  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006224

>  <SMILES>
O=C(N1C[C@H](N2CCOCC2)[C@@H]2OCCC[C@@H]21)C1(F)CCC1

$$$$
SWF006225
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
 22 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006225

>  <SMILES>
COCCN1CCC2(CCN(Cc3ccc(C)cc3)CC2)C1=O

$$$$
SWF006226
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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   11.4716   -5.0793   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
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 22 24  1  0  0  0  0
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 24 26  2  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006226

>  <SMILES>
O=C(NCCC1CCOC12CN(S(=O)(=O)C(F)(F)F)C2)c1ccccc1

$$$$
SWF006227
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 12  2  0  0  0  0
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 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
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 16 20  2  0  0  0  0
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 19 24  2  0  0  0  0
 21 25  2  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
 20 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006227

>  <SMILES>
O=C(c1cccc(O)c1)N1CC2(CC(OCc3ccncc3)CS2)C1

$$$$
SWF006228
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.1808   -0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116    0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808   -1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6162    1.4013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026   -0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7891    0.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8071    1.9890   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8936    1.5823   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0846    2.1701   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  6  0  0  0
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  7 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  2  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
  4  6  1  0  0  0  0
  9 10  1  0  0  0  0
 19 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006228

>  <SMILES>
Cc1ccnc(OC[C@@]23CCO[C@@H]2CCN(c2ncccn2)C3)n1

$$$$
SWF006229
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4135    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  6  0  0  0
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  8 11  1  6  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 12  1  6  0  0  0
 13 14  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF006229

>  <SMILES>
Cc1ccc(C(=O)N2C[C@@H]3[C@H](CNS(C)(=O)=O)CO[C@@H]3C2)o1

$$$$
SWF006230
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    3.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  6  9  1  0  0  0  0
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  8 11  1  1  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  6  0  0  0
 13 18  1  0  0  0  0
 14 19  2  0  0  0  0
 15 20  1  0  0  0  0
 16 21  1  0  0  0  0
 18 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 12  1  0  0  0  0
 17 20  1  0  0  0  0
 19 22  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006230

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@@H]2OCCN(Cc3ccncc3)[C@H]2C1

$$$$
SWF006231
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 13  1  6  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006231

>  <SMILES>
O=C(Cc1cccs1)N1CC[C@H]2CO[C@H](CN3CCCC3)[C@H]2C1

$$$$
SWF006232
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
   14.7420   -6.4423   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   13.5285   -5.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.7785   -7.8689   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.8412   -1.8618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006232

>  <SMILES>
COCCNC(=O)C1COC2(CN(Cc3cccs3)C2)CN1CC1CC1

$$$$
SWF006233
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.8585    3.3792   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  2  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006233

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)CCc3ccc[nH]3)CCC21

$$$$
SWF006234
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   -0.1708   -3.7240   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006234

>  <SMILES>
CS(=O)(=O)NC1CCc2onc(CN3CCOCC3)c2C1

$$$$
SWF006235
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006235

>  <SMILES>
COc1ccc(CC(=O)N2CC3(CCN(C(C)C)C3)C2)cc1F

$$$$
SWF006236
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006236

>  <SMILES>
Cc1nc(C(=O)N2CCC3CN(C4CCOCC4)CCOC3C2)cs1

$$$$
SWF006237
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006237

>  <SMILES>
N#CC1(C(=O)N2CCC3(CC2)CC(=O)N(CC2CCC2)C3)CCCC1

$$$$
SWF006238
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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 10 11  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006238

>  <SMILES>
Cn1cc(C(=O)N2CCC23CN(C(=O)C2(F)CCC2)C3)cn1

$$$$
SWF006239
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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  9 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006239

>  <SMILES>
CC(C)CN(C)C(=O)c1ncn2c1CCC(C(=O)N1CCCC1)C2

$$$$
SWF006240
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  0  0  0  0
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 27 29  2  0  0  0  0
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 18 20  2  0  0  0  0
 21 22  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006240

>  <SMILES>
Cc1cnc(C(=O)N2Cc3cn(-c4ccccc4)nc3-c3ccn(C)c3C2)cn1

$$$$
SWF006241
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 18 22  2  0  0  0  0
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M  END
>  <HTSID>
SWF006241

>  <SMILES>
c1ccc(OC2CCOC3(C2)CN(Cc2ccoc2)C3)nc1

$$$$
SWF006242
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   13.3460    3.0198   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006242

>  <SMILES>
CN(C)CCN1CCOC2CCN(C(=O)c3csnn3)CCC21

$$$$
SWF006243
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006243

>  <SMILES>
CSCC(=O)N1CC2(C1)OCCC2CCOc1ccccn1

$$$$
SWF006244
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    9.8258   -0.3885   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF006244

>  <SMILES>
COCCC1CN(Cc2ccc(F)cc2)Cc2cccn2C1

$$$$
SWF006245
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006245

>  <SMILES>
CC(=O)N1C[C@H]2C3(CCNCC3)CC[C@@]2(C(=O)NCC(C)C)C1

$$$$
SWF006246
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006246

>  <SMILES>
COc1ccc(OC)c(S(=O)(=O)N2CCCC3(CCCN(c4ncccn4)C3)C2)c1

$$$$
SWF006247
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 11  9  1  6  0  0  0
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 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF006247

>  <SMILES>
O=C(c1cscn1)N1CCOCC2(CCN(c3ncccn3)C2)C1

$$$$
SWF006248
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006248

>  <SMILES>
Cc1cccc(CN2CCCC3(CCCN(C(=O)c4cn(C)cn4)C3)C2)n1

$$$$
SWF006249
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 16  1  0  0  0  0
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 22 24  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006249

>  <SMILES>
O=C(C1=CCCC1)N1CCO[C@H]2[C@H](OCC3CCOCC3)CC[C@@H]21

$$$$
SWF006250
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
  9 10  2  0  0  0  0
 13 16  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006250

>  <SMILES>
COCC1Cc2c(ncn2C)CN1Cc1cnn(C(C)C)c1

$$$$
SWF006251
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.9646   -3.0772   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  9  1  0  0  0  0
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 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006251

>  <SMILES>
O=C(C1CCC1)N1CC2(C1)OCCC2COc1ccccn1

$$$$
SWF006252
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  2  0  0  0  0
 14 18  1  0  0  0  0
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M  END
>  <HTSID>
SWF006252

>  <SMILES>
Cc1ccc(S(=O)(=O)N2Cc3ncn(C)c3CC2CO)cc1

$$$$
SWF006253
Actelion Java MolfileCreator 1.0

 32 37  0  0  0  0  0  0  0  0999 V2000
    4.5468   -4.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0468   -3.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 30 32  2  0  0  0  0
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 26 28  1  0  0  0  0
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M  END
>  <HTSID>
SWF006253

>  <SMILES>
O=c1c2c(nc3n1CC1(CCN(Cc4ccoc4)CC1)C3)CCN(Cc1ccccc1)C2

$$$$
SWF006254
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.0688   -3.0425   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.8287    1.0862   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006254

>  <SMILES>
c1ccc(CN2CCOCC3(CCCN(c4ncccn4)C3)C2)nc1

$$$$
SWF006255
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.8206   -1.3578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  1  6  0  0  0
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  7 11  1  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  2  0  0  0  0
  6  8  1  0  0  0  0
  7 10  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006255

>  <SMILES>
c1ccc(CN2C[C@@H](OCc3ccncc3)[C@H]3OCCC[C@H]32)cc1

$$$$
SWF006256
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.8584    1.6906   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    9.1759    1.7996   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
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 11 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006256

>  <SMILES>
O=C(N1CCCC2(CCN(Cc3cccnc3)C2=O)C1)C1(F)CC1

$$$$
SWF006257
Actelion Java MolfileCreator 1.0

 25 29  0  0  1  0  0  0  0  0999 V2000
    6.6840   -1.4250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10  6  1  6  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
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 17 20  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  2  0  0  0  0
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M  END
>  <HTSID>
SWF006257

>  <SMILES>
O=C(NC1CCC1)C1=NO[C@@H]2CN(C(=O)c3cc(C4CC4)on3)C[C@H]12

$$$$
SWF006258
Actelion Java MolfileCreator 1.0

 19 21  0  0  0  0  0  0  0  0999 V2000
    3.4080    0.9432   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 10 11  1  0  0  0  0
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 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF006258

>  <SMILES>
CS(=O)(=O)N1CCCC12CCN(Cc1nccs1)C2

$$$$
SWF006259
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.4952    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4952    3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006259

>  <SMILES>
NC(=O)N1CCC2(CC1)CN(C(=O)c1cccs1)CCO2

$$$$
SWF006260
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
   -0.0579    0.6173   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.1589    1.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  8  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006260

>  <SMILES>
O=C(N1CCC2(CC(Nc3cccnc3)CO2)C1)C1(F)CCC1

$$$$
SWF006261
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   11.2792   -1.6107   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.8120   -1.2988   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4360   -3.1024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0620   -2.5978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0657   -3.7125   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5702   -2.7546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5665   -1.6399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8202   -4.0537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8783   -0.1727   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  2  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006261

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCC2(CC1)CCN(c1ccsc1)C2=O

$$$$
SWF006262
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    2.6425    3.6731   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9415    4.4231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3435    2.9231   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3925    2.3740   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8925    4.9721   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 10 13  2  0  0  0  0
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 14 18  1  0  0  0  0
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 12 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006262

>  <SMILES>
CNC(=O)[C@@]12CCC3(CCNCC3)[C@@H]1CN(S(C)(=O)=O)C2

$$$$
SWF006263
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.9684   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  4  6  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006263

>  <SMILES>
O=C1C2CN(Cc3cccs3)CC2CCN1Cc1ccncc1

$$$$
SWF006264
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3776   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.1636   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468    0.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
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 19 22  1  0  0  0  0
  5  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006264

>  <SMILES>
Cc1cc(C)cc(C(=O)N2CCCC3(CCN(C)C3=O)C2)c1

$$$$
SWF006265
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006265

>  <SMILES>
Cn1cc(C(=O)N[C@H]2C[C@]3(CCN(C(=O)C4(C)CC=CCC4)C3)C2)cn1

$$$$
SWF006266
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006266

>  <SMILES>
O=S(=O)(c1ccc2ncsc2c1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF006267
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006267

>  <SMILES>
O=C(NC1CCC1)C1CN(C(=O)C2CCC2)Cc2cncn21

$$$$
SWF006268
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006268

>  <SMILES>
Cc1ccsc1S(=O)(=O)N1CCCC2(CCCN(CC3CC3)C2)C1

$$$$
SWF006269
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006269

>  <SMILES>
C=CCOCC12CCCOC1CCN(Cc1ccccn1)C2

$$$$
SWF006270
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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   10.3923   -6.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.3923   -8.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006270

>  <SMILES>
c1cncc(CN2CCOC3(CCN(CC4CC4)CC3)C2)c1

$$$$
SWF006271
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  1  0  0  0
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 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006271

>  <SMILES>
O=C(c1ccnc(F)c1)N1C[C@@H]2OCCN(c3cnccn3)[C@H]2C1

$$$$
SWF006272
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  6  0  0  0
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 24 26  1  0  0  0  0
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 13 16  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006272

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1C[C@@H]2CCN(C(=O)CC3(O)CCC3)C[C@H]2O1

$$$$
SWF006273
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
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 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF006273

>  <SMILES>
CN(C)C(=O)CO[C@@H]1CC[C@H]2[C@H]1OCCN2Cc1ccncc1

$$$$
SWF006274
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006274

>  <SMILES>
COCCO[C@@H]1CCN(C(=O)c2ccoc2)[C@H]1Cc1ccccc1

$$$$
SWF006275
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  4  6  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006275

>  <SMILES>
O=C(CC1CC1)NCc1cn2c(n1)CN(Cc1cccs1)CC2

$$$$
SWF006276
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    7.8655   -0.6101   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7293    3.1740   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5852   -4.4672   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  1  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006276

>  <SMILES>
Cc1noc([C@H]2C[C@H]3OCC[C@H]3N(Cc3cnn(C)c3)C2)n1

$$$$
SWF006277
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
   12.9639    0.9935   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   13.7139    2.2925   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4967    1.3053   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7103    3.4072   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.2057    2.4493   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3399    2.7971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0409    3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7419    2.7971   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8540    1.3013   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5025    3.6421   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7544    0.2810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0691    3.2000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2674   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0539    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 14 12  1  6  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006277

>  <SMILES>
Cc1nc(CN2CC[C@@H]3CN(C(=O)CC4CCOCC4)C[C@@H]3CC2)cs1

$$$$
SWF006278
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.3429    3.8358   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.9362    2.9223   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9417    2.8178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5240    2.1133   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006278

>  <SMILES>
Fc1cnc(N2CCCC3(CCN(Cc4ccccn4)C3)C2)nc1

$$$$
SWF006279
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.2226    0.8578   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9209   -3.9407   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9699   -3.6317   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  8  7  1  6  0  0  0
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  8 10  1  0  0  0  0
  9 11  1  1  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  6  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006279

>  <SMILES>
CN(C)C(=O)CO[C@@H]1CC[C@H]2[C@H]1OCCN2Cc1ccco1

$$$$
SWF006280
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.2769    3.3125   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9679    2.3614   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370    1.6183   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3280    0.6672   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6152    1.8262   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 12 17  2  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006280

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2[C@H](OCc3ccncc3)CC[C@@H]21

$$$$
SWF006281
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
    6.6316    1.7228   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006281

>  <SMILES>
O=C(c1cccs1)N1CCO[C@H]2[C@H](OCC3CC3)CC[C@@H]21

$$$$
SWF006282
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 13  1  0  0  0  0
 11 14  2  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 16 17  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006282

>  <SMILES>
Cc1cc(CN2CCn3c(CCOc4ccccn4)cnc3C2C)no1

$$$$
SWF006283
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 10  1  6  0  0  0
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 16 18  1  0  0  0  0
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 20 21  2  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006283

>  <SMILES>
O=C1N(Cc2cccc(F)c2)CCC12CCN(Cc1ccccn1)C2

$$$$
SWF006284
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
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 17 18  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF006284

>  <SMILES>
CCS(=O)(=O)N1CCC2(CC1)c1ncc(C)n1CCN2C

$$$$
SWF006285
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF006285

>  <SMILES>
CC1CC(C(=O)N2CCC3(CC2)CC(NS(C)(=O)=O)C3)C1

$$$$
SWF006286
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006286

>  <SMILES>
CC(C)NC(=O)[C@@H]1C[C@@H]2CN(C(=O)c3cccnc3)C[C@@H]2C1

$$$$
SWF006287
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.4516   -0.3849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  9  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006287

>  <SMILES>
CN(C)C(=O)N1CCC2(CC1)CCN(Cc1ccccn1)C2=O

$$$$
SWF006288
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
 17 18  1  0  0  0  0
 20 22  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006288

>  <SMILES>
Cc1nc(C(=O)N2CCc3nn4ccc(N5CCCC5)nc4c3C2)cs1

$$$$
SWF006289
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.0356   -1.3931   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <HTSID>
SWF006289

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)Cc1ccc(C#N)cc1)C2

$$$$
SWF006290
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006290

>  <SMILES>
COC1(CC(=O)N2CCC3(CC2)OCC(=O)NC3C)CCC1

$$$$
SWF006291
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.5800    0.5305   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006291

>  <SMILES>
Cn1cc(CN2CC[C@@H]3[C@H]2CCC(=O)N3Cc2cccnc2)cn1

$$$$
SWF006292
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006292

>  <SMILES>
CCOCC(=O)NC1CCc2onc(CN3CCCC3)c2C1

$$$$
SWF006293
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 13  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006293

>  <SMILES>
O=C(c1cscn1)N1CC[C@@H]2[C@@H]1CCN2Cc1cccnc1

$$$$
SWF006294
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 14 12  1  1  0  0  0
 15 16  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF006294

>  <SMILES>
Cc1noc([C@H]2C[C@@H]3CCN(Cc4csc(C)n4)C[C@H]3O2)n1

$$$$
SWF006295
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.8971    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  8  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006295

>  <SMILES>
Cc1cccc(CN2CC[C@@H](N(C)C)[C@@H]2Cc2ccncc2)n1

$$$$
SWF006296
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
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 13 14  2  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006296

>  <SMILES>
CS(=O)(=O)N1Cc2ccnn2C(C(=O)NCC2CCOCC2)C1

$$$$
SWF006297
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.5349    1.9042   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  1  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
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 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
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 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006297

>  <SMILES>
O=C(c1cccnc1)N1CCCC2(CCN(Cc3ccco3)C2)C1

$$$$
SWF006298
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0740    0.2725   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.0893   -3.9782   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9326   -2.4864   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6822    1.3273   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  6  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
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 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 22 26  1  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006298

>  <SMILES>
Cc1noc(C)c1CN1CCC2(C1)CN(C(=O)C1(F)CC1)CCC2(F)F

$$$$
SWF006299
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    8.4036   -1.2006   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.4073   -0.0859   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9401    0.2260   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    7.1901   -3.3024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6451   -0.3618   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  6  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 20 24  1  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006299

>  <SMILES>
COCC(=O)N1CC2(C1)C(COc1nccc(C)n1)CCS2(=O)=O

$$$$
SWF006300
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 14 16  1  6  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  6  7  2  0  0  0  0
 13 14  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006300

>  <SMILES>
Cc1cc(N2CC[C@@H]3CN(C(=O)C4=CC=NC(=O)C4)C[C@@H]3CC2)ccn1

$$$$
SWF006301
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  1  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  2  0  0  0  0
 18 22  1  0  0  0  0
 19 23  2  0  0  0  0
 20 24  2  0  0  0  0
 22 25  2  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006301

>  <SMILES>
c1ccc(COC2COC3(CCN(Cc4ccccn4)CC3)C2)cc1

$$$$
SWF006302
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
 10 11  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006302

>  <SMILES>
CCC(CC)NC(=O)c1ncn2c1CCC(C(=O)NCC1CC1)C2

$$$$
SWF006303
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 27 29  2  0  0  0  0
  5  6  1  0  0  0  0
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 15 18  1  0  0  0  0
 19 20  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006303

>  <SMILES>
CC(c1ccccc1)N1CC2(COCCN(c3ncnc4ccsc34)C2)CC1=O

$$$$
SWF006304
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 18 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF006304

>  <SMILES>
Cc1cccc(C(=O)N2CCC3(CC2)CC(N2CCN(C)CC2)CO3)n1

$$$$
SWF006305
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    7.5335   -1.3985   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5  9  2  0  0  0  0
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 12 10  1  6  0  0  0
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 13 15  1  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006305

>  <SMILES>
Cn1ccc(C(=O)N2CCC3(Cc4nn(C)c(=O)c(=O)n4C3)C2)n1

$$$$
SWF006306
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  6  7  1  0  0  0  0
 16 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006306

>  <SMILES>
O=C1CCC2(CCCN(C(=O)Cc3ccc(F)cn3)CC2)N1

$$$$
SWF006307
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.8971    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
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 25 26  1  0  0  0  0
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 12 13  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006307

>  <SMILES>
CC1CC(C(=O)N2CCOCC3(CCC(Cn4ncccc4=O)O3)C2)C1

$$$$
SWF006308
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
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 14 16  1  0  0  0  0
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 17 18  2  0  0  0  0
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 20 22  1  6  0  0  0
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 22 24  1  0  0  0  0
  9 10  1  0  0  0  0
 13 15  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006308

>  <SMILES>
COCCN1CCCC2(CCN(C(=O)[C@H]3[C@@H]4COC[C@@H]43)CC2)C1=O

$$$$
SWF006309
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8974   -1.1728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4871    0.1818   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281    1.4690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2302    0.8509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0713    2.1381   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  7  1  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006309

>  <SMILES>
Cn1cc(CN2CCC3(CC(=O)N(c4ccccn4)C3)C2)cn1

$$$$
SWF006310
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.6770   -1.2661   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0078   -0.5229   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1770   -2.1321   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0943   -0.9297   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2283   -0.4297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1237    0.5649   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8669    1.2340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1456    0.7728   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
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  8  6  1  6  0  0  0
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  7 10  1  0  0  0  0
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 11 13  1  1  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006310

>  <SMILES>
O=C(c1ccccn1)N1CC[C@@H]2[C@@H]1CC(=O)N2c1ccsc1

$$$$
SWF006311
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
   -1.1919   -4.2014   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0217   -5.0831   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7283   -2.7748   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.6100   -1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.7765   -3.6612   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -3.7397   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.5665   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    6.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006311

>  <SMILES>
Cc1cc(CN2CC3(C2)OCCC3COCc2ccncc2)no1

$$$$
SWF006312
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1106    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6836    2.3817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  9 12  1  6  0  0  0
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  8  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006312

>  <SMILES>
O=C(CCn1cccn1)N1C[C@@H]2OCCN(CC3CC3)[C@H]2C1

$$$$
SWF006313
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4641   -2.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.3301   -4.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1391   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5211   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006313

>  <SMILES>
CN(C)C(=O)CC1CCC2(CC1)CCN(Cc1cnn(C)c1)CC2

$$$$
SWF006314
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -4.9142   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -4.4142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.4142   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -4.9142   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3052   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8910   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8185   -4.5075   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1494   -5.2506   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6494   -6.1166   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006314

>  <SMILES>
O=C(C1CCOC1)N1CC2(CC(Oc3cnccn3)CCO2)C1

$$$$
SWF006315
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  3  1  1  1  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 17 21  2  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006315

>  <SMILES>
Cc1cc(CN2Cc3cccn3CC(Oc3ccccn3)C2)n(C)n1

$$$$
SWF006316
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
 10  7  1  6  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  8  9  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006316

>  <SMILES>
O=C(NC[C@]12COC[C@H]1CN(Cc1ccncc1)C2)N1CCCC1

$$$$
SWF006317
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
  9 11  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  2  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006317

>  <SMILES>
CCN1CCn2c(-c3ccccc3)cnc2C12CCN(C(=O)COC)CC2

$$$$
SWF006318
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006318

>  <SMILES>
CN(C)C(=O)N1CCC2(CCN(Cc3cccnc3)C2)CC1

$$$$
SWF006319
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 19  1  0  0  0  0
 16 20  1  0  0  0  0
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 19 22  2  0  0  0  0
 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
  6  9  1  0  0  0  0
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 17 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006319

>  <SMILES>
Cc1cncc(COC2CCOC3(C2)CN(C2CCOCC2)C3)c1

$$$$
SWF006320
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   -0.0000    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 10 13  1  0  0  0  0
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 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006320

>  <SMILES>
O=C(c1ccoc1)N1CCC2OCCCC2(COc2ccccn2)C1

$$$$
SWF006321
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 18  1  0  0  0  0
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 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 11 12  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF006321

>  <SMILES>
CNC(=O)CC1CN(C(=O)c2ccn(C)n2)Cc2cccn2C1

$$$$
SWF006322
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <HTSID>
SWF006322

>  <SMILES>
CS(=O)(=O)NCc1cn2c(n1)CN(Cc1ccco1)CC2

$$$$
SWF006323
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 25 27  2  0  0  0  0
  6  8  1  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006323

>  <SMILES>
O=C(c1cccc(F)c1)N1CCOC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF006324
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    4.5856   -1.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.5686    0.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6291    0.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  4  9  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
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 14 18  2  0  0  0  0
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 23 26  2  0  0  0  0
  6  9  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006324

>  <SMILES>
Cc1ccccc1C(=O)N1CCCC2(CCN(c3cccnc3)C2=O)C1

$$$$
SWF006325
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    6.9073    1.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9128    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4347    1.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2318    3.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006325

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CC1)CC(=O)N(Cc1cccnc1)C2

$$$$
SWF006326
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.1980    2.3569   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006326

>  <SMILES>
Cc1cc(C(=O)N2CCCC3(CCN3CC3CCCO3)C2)no1

$$$$
SWF006327
Actelion Java MolfileCreator 1.0

 26 30  0  0  0  0  0  0  0  0999 V2000
    8.5492   -1.0986   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7402   -2.4999   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 23 24  1  0  0  0  0
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  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 19 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006327

>  <SMILES>
O=C(NC1CC1)C1CC2(CCN(Cc3cccs3)CC2)c2ccccc21

$$$$
SWF006328
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
    1.1980    2.3569   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 15 18  1  0  0  0  0
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 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006328

>  <SMILES>
Cc1noc(C)c1CN1CCC12CCCN(C(=O)c1ccc3ccccc3c1)C2

$$$$
SWF006329
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.6750    1.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006329

>  <SMILES>
O=C1CCC2(CCCN(Cc3nccs3)CC2)N1Cc1cncs1

$$$$
SWF006330
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006330

>  <SMILES>
Cc1ccc(N2CCC3(CCN(C(=O)c4cnccn4)CC3)C2)nn1

$$$$
SWF006331
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.0981    4.5388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7891    3.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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 10 12  1  0  0  0  0
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 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006331

>  <SMILES>
C=CCOCC12CCCOC1CCN(C(=O)c1cscn1)C2

$$$$
SWF006332
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.0539    1.4918   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006332

>  <SMILES>
CN(Cc1cccs1)C1CC2(CCN(Cc3nccn3C)CC2)C1

$$$$
SWF006333
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006333

>  <SMILES>
O=C(Cc1ccccc1)N1CCC2(CCC(=O)N(Cc3cccnc3)C2)CC1

$$$$
SWF006334
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006334

>  <SMILES>
O=C(c1cnco1)N1CCCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF006335
Actelion Java MolfileCreator 1.0

 21 22  0  0  0  0  0  0  0  0999 V2000
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 16 17  2  0  0  0  0
M  END
>  <HTSID>
SWF006335

>  <SMILES>
CC(C)C(=O)NCC1CCn2nccc2CN1S(C)(=O)=O

$$$$
SWF006336
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006336

>  <SMILES>
Cc1cccc(CN2CC3(CCN(C(=O)c4ccsc4)CC3)CC2=O)n1

$$$$
SWF006337
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006337

>  <SMILES>
Cc1ccccc1C(=O)N1CCCC2(CCN(Cc3cccnc3)C2=O)C1

$$$$
SWF006338
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 13 17  1  0  0  0  0
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M  END
>  <HTSID>
SWF006338

>  <SMILES>
Cc1oc(C(C)(C)C)cc1C(=O)N1CCCC2(CCN2C)C1

$$$$
SWF006339
Actelion Java MolfileCreator 1.0

 21 24  0  0  0  0  0  0  0  0999 V2000
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   -2.8580   -5.6116   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.2553   -4.7028   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 12  2  0  0  0  0
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 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006339

>  <SMILES>
c1cnc2c(c1)CN(Cc1nccs1)CCN2CC1CC1

$$$$
SWF006340
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    5.6313    1.4572   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9261    0.5016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  0  0  0  0
 10 16  1  6  0  0  0
 11 17  2  0  0  0  0
 13 18  1  0  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 12 17  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  2  0  0  0  0
M  END
>  <HTSID>
SWF006340

>  <SMILES>
CNC(=O)CC1CN(C(=O)c2ccc(C)nc2)Cc2cccn2C1

$$$$
SWF006341
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.1962   -2.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7942   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  7  9  1  0  0  0  0
 16 17  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006341

>  <SMILES>
O=C(Cc1cccc(F)c1F)N1CCC2(CC1)CC(N1CCCC1)C2

$$$$
SWF006342
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  2  0  0  0  0
 14 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  1  0  0  0
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 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006342

>  <SMILES>
O=C(C1CCC2(CCN(S(=O)(=O)c3ccccc3)CC2)O1)N1CCCC1

$$$$
SWF006343
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
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 21 23  1  0  0  0  0
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 25 26  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006343

>  <SMILES>
Cc1ccc(N2CCCC3(CN(C(=O)c4ccncc4)CCO3)C2)nn1

$$$$
SWF006344
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    5.9461   -3.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 11 12  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006344

>  <SMILES>
FC1(F)CCN(CC2CC2)CC12CCN(c1ncccn1)C2

$$$$
SWF006345
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 11  9  1  1  0  0  0
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 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006345

>  <SMILES>
O=C(N1CCCC2(CCN(Cc3cccnc3)C2=O)C1)C1(F)CCC1

$$$$
SWF006346
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006346

>  <SMILES>
Cc1nc(C(=O)N2CCOCC3(CN(CC4CC4)C(=O)CO3)C2)cs1

$$$$
SWF006347
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    6.4952   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 22  2  0  0  0  0
 22 23  1  0  0  0  0
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 10 11  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006347

>  <SMILES>
Cc1ccc(N2CCC3OCCCC3(COCC3CC3)C2)nn1

$$$$
SWF006348
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 15 16  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006348

>  <SMILES>
O=C1CCC2(CCCN(CCc3ccccc3)CC2)N1CC1CCCO1

$$$$
SWF006349
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <HTSID>
SWF006349

>  <SMILES>
O=C(N1CCCC2(CCCN2c2ncnc3ccccc23)CC1)C1(F)CC1

$$$$
SWF006350
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  2  0  0  0  0
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 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006350

>  <SMILES>
Cc1occc1C(=O)N1CCCC2(CCN(Cc3ccncc3)C2=O)C1

$$$$
SWF006351
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.0124    1.0516   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5349    1.9042   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1172    1.1997   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  4  8  1  0  0  0  0
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  7 10  1  0  0  0  0
 11  9  1  1  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
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 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006351

>  <SMILES>
O=C(N1CCCC2(CCN(Cc3ccncc3)C2=O)C1)C1(F)CCC1

$$$$
SWF006352
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.5856    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  7 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006352

>  <SMILES>
COCCN1CC2(COCCN(Cc3ccccc3)C2)CC1=O

$$$$
SWF006353
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8481   -2.0490   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 25 27  1  0  0  0  0
 26 28  1  0  0  0  0
  9 10  1  0  0  0  0
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 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006353

>  <SMILES>
CCS(=O)(=O)NC1CC2(CCN(Cc3ccnc(N4CCOCC4)c3)CC2)C1

$$$$
SWF006354
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
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  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  9 10  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006354

>  <SMILES>
O=C(NCC1CC1)C1CCC2(CCN(c3ncccn3)CC2)O1

$$$$
SWF006355
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006355

>  <SMILES>
Cc1cccc(C(=O)N2CC(F)(F)CC3(CCN(C)C3=O)C2)c1

$$$$
SWF006356
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    3.9273    1.7016   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8228    0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 18 21  2  0  0  0  0
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  6  8  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006356

>  <SMILES>
CC(C)C(=O)N1CC2(CC(Oc3ncccc3F)CS2)C1

$$$$
SWF006357
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006357

>  <SMILES>
O=C(C1CCC1)N1CCC2(CC1)OCCC2CCOCc1ccccn1

$$$$
SWF006358
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006358

>  <SMILES>
Cc1cnc(N2CCC3(CCN(C(=O)Cc4cccnc4)C3)CC2)nc1

$$$$
SWF006359
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
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 10 15  1  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006359

>  <SMILES>
O=C(c1ccco1)N1CCC2C1CCN2CC1CCOCC1

$$$$
SWF006360
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 13 15  1  0  0  0  0
 17 18  2  0  0  0  0
M  END
>  <HTSID>
SWF006360

>  <SMILES>
COCCC1CN(C(=O)c2cscn2)Cc2cccn2C1

$$$$
SWF006361
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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 13 15  1  6  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF006361

>  <SMILES>
Cn1nccc1CN1CC[C@@H]2CN(C(=O)c3sccc3F)C[C@@H]2CC1

$$$$
SWF006362
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.5468   -3.4345   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -2.5685   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  1  1  6  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8  9  1  0  0  0  0
 10 11  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006362

>  <SMILES>
COCCN1C[C@@H]2[C@@H](OC)CCN(Cc3cnn(C)c3)[C@@H]2C1

$$$$
SWF006363
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    7.8986   -2.4487   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8986   -2.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.3986   -3.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 10 14  1  6  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 21 22  1  0  0  0  0
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 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006363

>  <SMILES>
COCCCN1CCO[C@H]2CN(C(=O)c3cncnc3)C[C@@H]21

$$$$
SWF006364
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006364

>  <SMILES>
O=C(c1ccnnc1)N1CCC2OCCCC2(COCC2CC2)C1

$$$$
SWF006365
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.0622    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  2  0  0  0  0
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 21 23  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006365

>  <SMILES>
CC(=O)N1CCC2(CC1)CN(C(=O)c1ccc(C)nc1)CCO2

$$$$
SWF006366
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    5.8910    2.5524   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
  6  9  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006366

>  <SMILES>
CC(C)C(=O)N1CC2(C1)C(COc1ncccn1)CCS2(=O)=O

$$$$
SWF006367
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
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 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 15 18  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006367

>  <SMILES>
CN(C)C(=O)COCC12CCCOC1CCN(C1CCC1)C2

$$$$
SWF006368
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 10 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF006368

>  <SMILES>
c1cncc(CO[C@@H]2CN(Cc3nccs3)[C@@H]3CCCO[C@@H]32)c1

$$$$
SWF006369
Actelion Java MolfileCreator 1.0

 27 31  0  0  0  0  0  0  0  0999 V2000
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 25 27  2  0  0  0  0
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 11 12  1  0  0  0  0
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M  END
>  <HTSID>
SWF006369

>  <SMILES>
O=C(c1ccsc1)N1CC2C(C1)n1cccc1C(=O)N2Cc1ccccn1

$$$$
SWF006370
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 10 14  2  0  0  0  0
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M  END
>  <HTSID>
SWF006370

>  <SMILES>
Cc1ncoc1C(=O)N1CC(F)(F)CC2(CCN(CC3CC3)C2=O)C1

$$$$
SWF006371
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 23 24  2  0  0  0  0
  7  8  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006371

>  <SMILES>
C=CCN1CC[C@]2(CN(C(=O)c3ccc(C)c(F)c3)C[C@H]2C)C1=O

$$$$
SWF006372
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006372

>  <SMILES>
CCOCC12CCCOC1CCN(C(=O)c1ccncn1)C2

$$$$
SWF006373
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.9736   -6.1321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5033   -2.2706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006373

>  <SMILES>
CCCC(=O)N1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF006374
Actelion Java MolfileCreator 1.0

 29 32  0  0  0  0  0  0  0  0999 V2000
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 27 29  2  0  0  0  0
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 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
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M  END
>  <HTSID>
SWF006374

>  <SMILES>
CN(Cc1ccccn1)C(=O)C1CN(CC2CC2)CC2(CCN(S(C)(=O)=O)C2)O1

$$$$
SWF006375
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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  6 10  1  6  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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M  END
>  <HTSID>
SWF006375

>  <SMILES>
Cc1cccc(C(=O)N2CC3(C2)C(COCc2ccccn2)CCS3(=O)=O)c1

$$$$
SWF006376
Actelion Java MolfileCreator 1.0

 20 21  0  0  0  0  0  0  0  0999 V2000
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 13 15  2  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  6  9  1  0  0  0  0
  8 11  1  0  0  0  0
M  END
>  <HTSID>
SWF006376

>  <SMILES>
CCOCC1CCS(=O)(=O)C12CN(C(=O)CC(C)C)C2

$$$$
SWF006377
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.9736   -6.1321   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5033   -2.2706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  1  0  0  0
 14 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  6  8  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006377

>  <SMILES>
COCC(=O)N1CC2(C1)OCCC2COCc1ccccn1

$$$$
SWF006378
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    7.1152   -0.2873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4461   -1.0305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
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 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 11 15  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006378

>  <SMILES>
CC1c2nnc(COc3ccccn3)n2CCN1C(=O)c1ccoc1

$$$$
SWF006379
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 11  1  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006379

>  <SMILES>
CS(=O)(=O)N1CCC2(CCN(c3ncccn3)CC2)CC1

$$$$
SWF006380
Actelion Java MolfileCreator 1.0

 20 21  0  0  1  0  0  0  0  0999 V2000
    8.6706   -4.1572   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   11.3400   -4.2971   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.6390   -3.5471   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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 11 13  1  0  0  0  0
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 14 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
M  END
>  <HTSID>
SWF006380

>  <SMILES>
CCN1C[C@H]2CCN(C(=O)CC(C)C)CC[C@H]2S1(=O)=O

$$$$
SWF006381
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6836   -3.8817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  2  0  0  0  0
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 11 16  1  0  0  0  0
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 18 20  1  0  0  0  0
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 22 23  1  0  0  0  0
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 15 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006381

>  <SMILES>
CC(=O)N1CC(F)(F)CC2(CCN(c3ccc(C)nc3)C2=O)C1

$$$$
SWF006382
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.9402   -1.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6019    0.3226   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6748   -2.5306   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
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 10 16  1  0  0  0  0
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 15 18  1  1  0  0  0
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 22 24  2  0  0  0  0
 11 14  1  0  0  0  0
 13 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006382

>  <SMILES>
O=C(c1cnccn1)N1CCO[C@H]2[C@H](Oc3cccnc3)CC[C@@H]21

$$$$
SWF006383
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4071    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
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  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  6 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 13  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006383

>  <SMILES>
CC(C)NC(=O)C1CN(Cc2ccco2)CC12CCOCC2

$$$$
SWF006384
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
    3.6665    6.0468   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1665    7.9128   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1665    3.4487   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6665    4.3147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  1  6  0  0  0
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 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
  7  8  1  0  0  0  0
 10 12  1  0  0  0  0
 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006384

>  <SMILES>
O=C(C1CC1)N1CCCC(c2nc3ccc(NCc4ccccc4)cn3n2)C1

$$$$
SWF006385
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.8783    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   13.1258   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  7 10  1  0  0  0  0
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  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006385

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3ccccc3)CC2)CC1=O

$$$$
SWF006386
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
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  4  2  1  6  0  0  0
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  5  8  2  0  0  0  0
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  6 10  1  0  0  0  0
  6 11  1  6  0  0  0
  7 12  1  0  0  0  0
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  9 14  2  0  0  0  0
 10 15  1  6  0  0  0
 10 16  1  0  0  0  0
 11 17  1  0  0  0  0
 13 18  2  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
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 12 15  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF006386

>  <SMILES>
O=C(Nc1cnccn1)[C@@H]1CCO[C@@H]2CCN(Cc3ccncc3)C[C@@H]21

$$$$
SWF006387
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006387

>  <SMILES>
COCCN1CCC2(CCN(C(=O)c3cccnc3)CC2)C1=O

$$$$
SWF006388
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    6.8976    0.6423   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 20  1  0  0  0  0
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 20 24  2  0  0  0  0
 22 25  1  0  0  0  0
  7  9  1  0  0  0  0
 10 11  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006388

>  <SMILES>
c1ccc(CN2CCOCC3(CCC(CN4CCOCC4)O3)C2)nc1

$$$$
SWF006389
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  2  0  0  0  0
 13 10  1  6  0  0  0
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 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 19 20  1  0  0  0  0
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 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  7  1  0  0  0  0
 13 14  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006389

>  <SMILES>
O=C1N(Cc2cccc(F)c2)CCC12CCN(Cc1ccncc1)C2

$$$$
SWF006390
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    0.9992   -3.9059   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  7 10  1  0  0  0  0
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 11 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  5  8  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006390

>  <SMILES>
O=C(N1CC2(C1)OCCC2COCc1ccncc1)C1(F)CCC1

$$$$
SWF006391
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.9824   -4.0881   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  1  0  0  0
 14 19  3  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6  9  1  0  0  0  0
 11 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006391

>  <SMILES>
COCCC1CCOC12CN(C(=O)c1cccc(C#N)c1)C2

$$$$
SWF006392
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 13 14  1  0  0  0  0
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006392

>  <SMILES>
Cn1cc(CN2CCO[C@H]3[C@H](Oc4ncccc4F)CC[C@@H]32)cn1

$$$$
SWF006393
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    6.1667    3.9945   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006393

>  <SMILES>
COCCN1CCO[C@H]2CCN(Cc3nc(C)cs3)C[C@@H]21

$$$$
SWF006394
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006394

>  <SMILES>
O=C(NCc1ccco1)[C@H]1CC[C@@H]2[C@@H](CCN2Cc2cccs2)O1

$$$$
SWF006395
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.3657    2.4250   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006395

>  <SMILES>
c1ccc(CN2CCCC3(CCN(c4ncccn4)C3)C2)nc1

$$$$
SWF006396
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006396

>  <SMILES>
O=C(c1cscn1)N1CC[C@@H]2[C@@H]1CCN2Cc1ccccn1

$$$$
SWF006397
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006397

>  <SMILES>
O=C(c1cc[nH]n1)N1CCC2(CC(Oc3ncccn3)CO2)C1

$$$$
SWF006398
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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  9 10  1  0  0  0  0
 11 12  2  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006398

>  <SMILES>
O=C(c1ccco1)N1CCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF006399
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.8301   -5.5388   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1391   -4.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8301   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  1  0  0  0  0
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 23 24  1  0  0  0  0
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006399

>  <SMILES>
Cn1cc(CN2CCC3(CC2)CN(c2ccsc2)C(=O)CO3)cn1

$$$$
SWF006400
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.9595    1.6637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 14  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006400

>  <SMILES>
C=CCN1CCC2(CCN(Cc3ccc(OC)cc3)CC2)C1=O

$$$$
SWF006401
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006401

>  <SMILES>
COCC12CCCOC1CCN(C(=O)Cc1cccc(F)c1)C2

$$$$
SWF006402
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006402

>  <SMILES>
CCN1CCn2c(-c3ccccc3)cnc2C12CCN(S(C)(=O)=O)CC2

$$$$
SWF006403
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006403

>  <SMILES>
O=C(c1cccnc1)N1CCC2(CC1)CN(c1ccsc1)C(=O)CO2

$$$$
SWF006404
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2634   -2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  1  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
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 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006404

>  <SMILES>
Cc1ccc(CN2C[C@@H]3CN(C(=O)c4cnccn4)C[C@@H]3C2)o1

$$$$
SWF006405
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9113   -1.1153   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0379   -1.6023   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6 10  1  0  0  0  0
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 10 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
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 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
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 22 25  1  0  0  0  0
  5  7  1  0  0  0  0
 15 16  1  0  0  0  0
 17 18  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <HTSID>
SWF006405

>  <SMILES>
Cn1cncc1CN1CCCC2(CCC(=O)N2CC2CCCO2)CC1

$$$$
SWF006406
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    8.7293    4.6740   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    3.3037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    2.9918   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    2.0046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5373    3.9955   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006406

>  <SMILES>
CN(C)C(=O)N1CCC2(CCC(=O)N2Cc2ccccc2)CC1

$$$$
SWF006407
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
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 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006407

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC(=O)N(c4cnn(C)c4)C3)C2)cs1

$$$$
SWF006408
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.9300    2.3569   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9300    2.3569   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4300    1.4909   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9300    0.6248   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4300    1.4909   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10 15  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006408

>  <SMILES>
COCCN1CCC12CCCN(C(=O)c1ccc(C)cc1C)C2

$$$$
SWF006409
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
   11.9658    4.8803   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.5956    5.4904   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8090    6.3721   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4859    5.2687   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  9 10  1  0  0  0  0
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M  END
>  <HTSID>
SWF006409

>  <SMILES>
CC(C)C(=O)N1CCC2(C1)CN(C(=O)C1CC(F)(F)C1)C2

$$$$
SWF006410
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 16 19  1  0  0  0  0
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 23 26  1  0  0  0  0
  4  6  1  0  0  0  0
 11 12  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006410

>  <SMILES>
Cc1cccc(CN2CCOCC3(CC(=O)N(Cc4cncs4)C3)C2)c1

$$$$
SWF006411
Actelion Java MolfileCreator 1.0

 28 32  0  0  0  0  0  0  0  0999 V2000
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  9  8  1  1  0  0  0
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 11 14  1  0  0  0  0
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 15 17  1  0  0  0  0
 23 25  1  0  0  0  0
 27 28  2  0  0  0  0
M  END
>  <HTSID>
SWF006411

>  <SMILES>
Cc1ncc(CN2CCC23CCCN(C(=O)c2nccc4ccccc24)C3)s1

$$$$
SWF006412
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
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 10 13  1  0  0  0  0
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 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
  5  7  1  0  0  0  0
 13 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006412

>  <SMILES>
COCCN1CC2(CCN(C(=O)c3occc3C)CC2)CC1=O

$$$$
SWF006413
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
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 11  8  1  1  0  0  0
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 17 19  1  0  0  0  0
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  5  6  1  0  0  0  0
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 15 16  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006413

>  <SMILES>
CC(=O)NCC(=O)N1CCCC2(CCCN2c2ncnc3ccsc23)CC1

$$$$
SWF006414
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
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  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006414

>  <SMILES>
O=C1CC[C@@H]2[C@@H](CCN2Cc2ccccn2)N1Cc1ccncc1

$$$$
SWF006415
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9025   -1.6454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 15 19  2  0  0  0  0
 15 20  1  0  0  0  0
 17 21  2  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 20 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
  5  9  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006415

>  <SMILES>
Cc1cccc(CN2CCC3(CCCN(C(=O)c4conc4C)C3)C2=O)n1

$$$$
SWF006416
Actelion Java MolfileCreator 1.0

 30 33  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0727    3.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3196    3.9088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
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 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
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 16 20  2  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
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 21 24  1  0  0  0  0
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 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 25 28  2  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 12 15  1  0  0  0  0
 13 14  1  0  0  0  0
 17 20  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006416

>  <SMILES>
COCc1ccc(C(=O)N2CCc3ncc(-c4ccccc4COC)n3CC2)cc1

$$$$
SWF006417
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5308    6.2989   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006417

>  <SMILES>
O=C(C1CC(O)C1)N1CCC2(CC1)CC(N1CCCC1)CO2

$$$$
SWF006418
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.0052    3.0878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6962    4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <HTSID>
SWF006418

>  <SMILES>
O=C(Cc1cccs1)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF006419
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
    3.6038    4.2416   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2806    3.2952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3250    3.0005   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8562    2.4775   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3101    2.0006   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.2564    1.6774   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6054    3.2073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5233    0.9972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2452    1.5283   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7452    0.6623   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1763    1.6380   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1735    1.7127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6130    2.4642   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6074    2.6137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0469    3.3652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6046    2.6884   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0441    3.4399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0385    3.5894   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  6  0  0  0
  7 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  1  0  0  0  0
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 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  1  0  0  0  0
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 26 28  1  0  0  0  0
  5  7  1  0  0  0  0
 14 15  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006419

>  <SMILES>
CCN1CC2(CC1=O)CN(Cc1cccc(OC)c1)CCN(C(=O)C(C)C)C2

$$$$
SWF006420
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1215    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3783    1.5540   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0725    1.1939   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0772   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5373    2.8412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2974   -4.5476   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7151   -5.2521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7041   -5.4611   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1218   -6.1656   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1164   -6.2702   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6987   -5.5657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
  8  9  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006420

>  <SMILES>
COCC1CC2(CCN(c3cccc(C)n3)CC2)CN1c1ncccn1

$$$$
SWF006421
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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   -1.5827   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  7 10  1  0  0  0  0
  8 11  2  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006421

>  <SMILES>
O=C(c1cnccn1)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF006422
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.3147   -0.8364   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  3  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 11 15  1  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006422

>  <SMILES>
O=C(c1ccsc1)N1CCOC2(C1)C(=O)NCC2c1ccccc1

$$$$
SWF006423
Actelion Java MolfileCreator 1.0

 29 33  0  0  1  0  0  0  0  0999 V2000
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9721    3.9415   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2221    2.6425   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  4  1  1  6  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 11 14  1  0  0  0  0
 12 15  2  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  2  0  0  0  0
 21 25  1  0  0  0  0
 22 26  1  0  0  0  0
 23 27  2  0  0  0  0
 25 28  1  0  0  0  0
 25 29  1  0  0  0  0
  8  9  2  0  0  0  0
 10 11  1  0  0  0  0
 15 16  1  0  0  0  0
 24 27  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006423

>  <SMILES>
CC1CCCN(c2ncc3c(n2)[C@H]2CN(Cc4cccnc4)C[C@H]2S(=O)(=O)C3)C1

$$$$
SWF006424
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    3.8703   -0.8004   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5395   -1.5435   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 22  1  0  0  0  0
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M  END
>  <HTSID>
SWF006424

>  <SMILES>
Cc1ccc(C(=O)N2CC3(CC(Oc4cccnc4)CS3)C2)cc1

$$$$
SWF006425
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    6.2492   -0.2127   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5800    0.5305   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8891    1.4815   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11  7  1  6  0  0  0
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 22 24  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006425

>  <SMILES>
Cc1ccc(CN2CC[C@H]3O[C@@H](C(=O)N4CCCCO4)CC[C@H]32)o1

$$$$
SWF006426
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006426

>  <SMILES>
O=C(Cc1cccc(F)c1)N1CCCC2(CCNC2=O)CC1

$$$$
SWF006427
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 22 24  2  0  0  0  0
 24 25  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006427

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccc(F)cc2)C1

$$$$
SWF006428
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.0362    1.1275   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006428

>  <SMILES>
COCCN1CCC2(CCCN(C(=O)C3(F)CC3)CC2)C1=O

$$$$
SWF006429
Actelion Java MolfileCreator 1.0

 24 28  0  0  0  0  0  0  0  0999 V2000
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  9 14  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
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 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
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 22 24  2  0  0  0  0
  7  9  1  0  0  0  0
 12 13  2  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006429

>  <SMILES>
O=C1c2cccn2C2CN(Cc3ccncc3)CC2N1CC1CC1

$$$$
SWF006430
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.8712   -3.5878   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622   -4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2532   -3.5878   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622   -4.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006430

>  <SMILES>
COCC(=O)N1CCC(Nc2nccs2)(C(=O)NC2CC2)CC1

$$$$
SWF006431
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10  8  1  1  0  0  0
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 13 15  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006431

>  <SMILES>
CNC(=O)[C@H]1C[C@H]2OCC[C@H]2N(Cc2cccc(OC)c2)C1

$$$$
SWF006432
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.7121    7.5595   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5539    6.0542   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1925    7.8741   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2431    5.2974   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 11 14  1  0  0  0  0
 19 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006432

>  <SMILES>
O=C(NCC1CC1)C1(n2ccnc2)CCCN(Cc2cccs2)C1

$$$$
SWF006433
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    5.6295   -2.9049   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7634   -3.4049   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
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 19 21  1  1  0  0  0
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 21 23  1  0  0  0  0
  9 10  1  0  0  0  0
 13 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006433

>  <SMILES>
COc1ccc(C(=O)N2CC[C@]3(C[C@@H](OC)CO3)C2)c(OC)c1

$$$$
SWF006434
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8147   -1.7024   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0934   -2.1637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 10  9  1  6  0  0  0
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 21 23  1  0  0  0  0
  4  5  1  0  0  0  0
 12 14  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006434

>  <SMILES>
Cc1snnc1C(=O)N1C[C@H](N2CCOCC2)[C@@H]2OCCC[C@@H]21

$$$$
SWF006435
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.0622    0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006435

>  <SMILES>
O=C(c1ccccc1)N1CCOC2(CCN(Cc3ccccn3)CC2)C1

$$$$
SWF006436
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    4.8281    0.6030   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0360   -0.3752   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2929   -1.0443   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9871   -0.6842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1950   -1.6624   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7302   -0.0151   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7792    0.2939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4839   -2.4456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1460   -1.9714   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6813   -0.3241   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8892   -1.3022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  5 10  1  0  0  0  0
  5 11  1  0  0  0  0
  6 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
 10 15  1  1  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 12  1  0  0  0  0
 14 17  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006436

>  <SMILES>
CC1(C(=O)N2CC[C@H]3CN(Cc4cccnc4)C[C@H]32)CC=CCC1

$$$$
SWF006437
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    5.7631    1.0409   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1753    0.2319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820   -1.5477   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5602   -0.8896   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9898    2.1535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511   -2.2908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875   -1.6522   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6647   -1.8841   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0335    1.7377   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3206    2.8966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6466   -3.2854   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.3425    2.6887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -3.8731   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3692   -3.4664   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  1  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  2  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  0  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  1  0  0  0
 10 16  1  0  0  0  0
 11 17  1  6  0  0  0
 12 18  1  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
  9 11  1  0  0  0  0
 12 14  2  0  0  0  0
 16 20  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006437

>  <SMILES>
CCO[C@H]1CN(C(=O)c2cc3ccccc3n2C)[C@@H]2CCCO[C@H]12

$$$$
SWF006438
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641    1.5000   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0739   -2.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4752   -2.1691   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0685   -3.0827   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4048   -3.7213   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5733   -3.5134   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3165   -4.1825   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9801   -2.5998   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.9746   -2.7044   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  6  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  7  8  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006438

>  <SMILES>
O=C(CCc1ccccc1Cl)NC1CCc2onc(CN3CCCC3)c2C1

$$$$
SWF006439
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.3046   -1.3675   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2298   -2.3647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0959   -2.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9619   -2.3647   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.8279   -2.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2298   -4.3647   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9619   -4.3647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8279   -3.8647   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  6  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  6  0  0  0
 16 18  1  6  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  2  0  0  0  0
 25 28  2  0  0  0  0
  7  8  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006439

>  <SMILES>
O=C(Nc1ccc(F)c(F)c1)N1C[C@H]2CCN(c3ncccc3F)CC[C@H]2C1

$$$$
SWF006440
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -1.3109   -6.0547   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3109   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -2.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9326   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9326   -1.5137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2435   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9326   -1.5137   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6218   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5544   -1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3155   -2.1293   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2403   -0.0161   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6339    0.0157   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3283   -1.0045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5715    0.3064   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109    1.5137   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  2  0  0  0  0
 16 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006440

>  <SMILES>
Cc1ccc(C(=O)N2CCC(C(=O)N(C)C)(n3cccn3)CC2)cn1

$$$$
SWF006441
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0648   -3.3653   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3596   -4.3209   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811   -4.4888   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5772   -0.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2037   -5.1472   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2009   -5.2219   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5663   -6.1528   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5551   -6.3018   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  2  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  6  0  0  0
  8 13  1  0  0  0  0
 10 14  1  0  0  0  0
 11 15  2  0  0  0  0
 12 16  1  0  0  0  0
 13 17  1  6  0  0  0
 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 13  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006441

>  <SMILES>
CCN1CCO[C@@H]2CN(C(=O)Cc3ccn(C)n3)CC[C@@H]2C1

$$$$
SWF006442
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5468   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9135   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1045   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5827   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0827   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2120   -0.0593   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3598   -1.4657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9891   -0.6886   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9837   -0.5841   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3904    0.3295   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8026    1.1385   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3849    0.4340   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7917    1.3476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9727   -0.3750   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7862    1.4521   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9672   -0.2705   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3740    0.6431   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  6  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006442

>  <SMILES>
O=C(N[C@H]1C[C@]2(CCN(C(=O)/C=C/c3cccs3)C2)C1)c1ccncc1

$$$$
SWF006443
Actelion Java MolfileCreator 1.0

 28 30  0  0  0  0  0  0  0  0999 V2000
   11.1423   -2.0490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8923   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7943   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0933    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7943    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7943   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3923    3.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7943    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7943    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952    6.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    5.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4462    6.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6962    5.2500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 25 28  1  0  0  0  0
  7  9  1  0  0  0  0
 16 19  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006443

>  <SMILES>
COCCN1CCCC2(CN(C(=O)C3CCC(F)(F)CC3)CC(F)(F)C2)C1=O

$$$$
SWF006444
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
   10.4805    5.2945   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.4805    3.7818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1704    3.0255   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7905    3.0255   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8604    3.7818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1704    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7905    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1006    3.7818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5503    3.0255   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8604    0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1006    0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4805    0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4106    3.0255   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5503    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4106    1.5127   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2402    0.7564   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5503   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8583    1.3716   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9328   -0.7403   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5388   -0.7720   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8604   -0.7564   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8461    0.2475   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6024   -1.0626   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1704   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4805   -0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7905   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.1006   -0.7564   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
 11 15  2  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006444

>  <SMILES>
COCCNC(=O)C1(n2cccn2)CCN(C(=O)c2ccccc2C)CC1

$$$$
SWF006445
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
    6.7375    1.6235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  5 10  1  0  0  0  0
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  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
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 25 27  2  0  0  0  0
 11 16  1  0  0  0  0
 12 15  1  0  0  0  0
 14 17  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006445

>  <SMILES>
O=C(CCc1cncnc1)N1CC[C@H]2OCC[C@@]2(C(=O)N2CCOCC2)C1

$$$$
SWF006446
Actelion Java MolfileCreator 1.0

 31 34  0  0  0  0  0  0  0  0999 V2000
    9.5263   -1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6603   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
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 17 19  2  0  0  0  0
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 22 25  2  0  0  0  0
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 27 28  1  0  0  0  0
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 29 31  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 18 19  1  0  0  0  0
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M  END
>  <HTSID>
SWF006446

>  <SMILES>
CCN(CC)C(=O)CC1CC2(CCN(C(=O)c3ccccc3)CC2)Oc2ccccc21

$$$$
SWF006447
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    7.5023   -3.8031   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3456   -2.3113   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
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  2  5  1  0  0  0  0
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 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  2  0  0  0  0
 13 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
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 20 23  2  0  0  0  0
  7  9  1  0  0  0  0
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006447

>  <SMILES>
CCN1CCC2(CN(C(=O)c3ncccn3)CC(F)(F)C2)C1=O

$$$$
SWF006448
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  6  8  1  0  0  0  0
 16 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006448

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2ccccn2)CC1

$$$$
SWF006449
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -4.2221   -1.9463   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9721   -3.2454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7549   -2.2582   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9684   -4.3601   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5981   -3.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2990   -6.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 22 24  1  0  0  0  0
 22 25  2  0  0  0  0
  4  5  1  0  0  0  0
 12 13  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006449

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)c2cscn2)CC1

$$$$
SWF006450
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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  1  2  1  0  0  0  0
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  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  1  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
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 19 20  1  0  0  0  0
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 20 22  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006450

>  <SMILES>
Cc1nc(C(=O)N2CC[C@]3(CCC[C@H](CN(C)C)O3)C2)cs1

$$$$
SWF006451
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  -11.2108   -4.7113   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
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 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  1  0  0  0  0
 25 28  2  0  0  0  0
  4  6  1  0  0  0  0
 14 15  1  0  0  0  0
 18 19  1  0  0  0  0
 26 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006451

>  <SMILES>
O=C(/C=C/c1cccs1)N1CCC2(CC1)CC(=O)N(Cc1cccc(F)c1)C2

$$$$
SWF006452
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.0727   -7.8781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8227  -10.1864   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6091   -9.3047   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 21 19  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006452

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)C4CCOC4)CC3)CC2=O)cs1

$$$$
SWF006453
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.0981   -0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0981    0.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  2  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006453

>  <SMILES>
Cc1ccccc1CNC1CCc2onc(CNS(C)(=O)=O)c2C1

$$$$
SWF006454
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
    4.1402    3.7885   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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  9 11  1  0  0  0  0
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 10 13  1  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  2  0  0  0  0
 14 18  2  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006454

>  <SMILES>
CCC(=O)N1CCC(C(=O)NCC(F)(F)F)(n2cccn2)CC1

$$$$
SWF006455
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3917   -2.6535   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2556   -3.1887   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7226   -3.3966   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.6861   -6.4351   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7794   -4.6555   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 17  1  0  0  0  0
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 20 23  1  0  0  0  0
 10 11  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <HTSID>
SWF006455

>  <SMILES>
Cc1ncsc1CNC1CCc2onc(CNS(C)(=O)=O)c2C1

$$$$
SWF006456
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  1  0  0  0
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 11 16  2  0  0  0  0
 13 17  1  0  0  0  0
 14 18  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 19 23  1  0  0  0  0
 20 24  1  0  0  0  0
 21 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006456

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCCN(C(=O)c2ccccn2)C1

$$$$
SWF006457
Actelion Java MolfileCreator 1.0

 29 33  0  0  0  0  0  0  0  0999 V2000
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   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6822    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
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 25 28  2  0  0  0  0
 27 29  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 24 26  1  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <HTSID>
SWF006457

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)c4cnn5ccccc45)CC3)CC2=O)cs1

$$$$
SWF006458
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.5981   -3.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.4909    1.3320   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  2  0  0  0  0
  8 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  6  0  0  0
 16 19  1  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 18 22  1  0  0  0  0
  9 10  1  0  0  0  0
 17 19  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006458

>  <SMILES>
CN1CCC12CCCN(C(=O)c1ccnc(C(F)(F)F)c1)C2

$$$$
SWF006459
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    4.8669    1.2340   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
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  6  8  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  6  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  2  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 11 13  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006459

>  <SMILES>
CC1CCC(C(=O)N2CC[C@H]3CN(S(C)(=O)=O)C[C@H]32)CC1

$$$$
SWF006460
Actelion Java MolfileCreator 1.0

 26 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006460

>  <SMILES>
CCC(CC)CN1CCC(Nc2ccn(C)n2)(C(=O)NCCOC)CC1

$$$$
SWF006461
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006461

>  <SMILES>
Cn1cnc(C(=O)N2CC[C@]3(C2)C[C@@H](NC(=O)C2CC2)C3)n1

$$$$
SWF006462
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    9.0435    1.7809   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8681    2.2713   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006462

>  <SMILES>
CCC(=O)N1CCC(C(=O)Nc2ccn(C)n2)(n2cccn2)CC1

$$$$
SWF006463
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006463

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCN(C(=O)c2cscn2)CC1

$$$$
SWF006464
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  8  1  1  0  0  0
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 22 24  1  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006464

>  <SMILES>
O=C(CC1(O)CCC1)N1C[C@@H]2CN(Cc3cccs3)CCO[C@@H]2C1

$$$$
SWF006465
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3776   -0.0933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006465

>  <SMILES>
CN1CCOC2(CCCN(C(=O)/C=C/c3cccs3)CC2)C1

$$$$
SWF006466
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    4.1385    3.7870   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6237    3.7870   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.1089    3.7870   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6237    2.2722   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3118    1.5148   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -6.5592   -3.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
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 10 13  1  0  0  0  0
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 14 18  2  0  0  0  0
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 22 24  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006466

>  <SMILES>
CC(C)C(=O)N1CCC(C(=O)NCC(F)(F)F)(n2cccn2)CC1

$$$$
SWF006467
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    6.4952   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -4.9842   -6.8597   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006467

>  <SMILES>
Cn1c(C(=O)N2CCC3(CC2)CN(CC2CC2)C3=O)cccc1=O

$$$$
SWF006468
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   -1.3109   -6.0547   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3109   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -3.7842   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6218   -3.7842   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3109   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.9326   -4.5410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7568   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 11 14  2  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006468

>  <SMILES>
Cc1cccc(C(=O)N2CCC(C(=O)N(C)C)(n3cccn3)CC2)c1

$$$$
SWF006469
Actelion Java MolfileCreator 1.0

 24 25  0  0  0  0  0  0  0  0999 V2000
    7.7942   -5.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622   -5.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -4.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 13  2  0  0  0  0
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 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
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 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
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 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  6  8  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006469

>  <SMILES>
COCC(=O)N1CCC(Nc2cccc(F)c2)(C(=O)N(C)C)CC1

$$$$
SWF006470
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    8.2107   -6.8334   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7435   -6.5215   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  2  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006470

>  <SMILES>
CC(=O)N1CCn2c(COCc3ccncc3)cnc2C1C

$$$$
SWF006471
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    6.9955   -5.5388   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -5.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2634   -5.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3974   -4.0388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1295   -2.0388   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
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  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 13 11  1  1  0  0  0
 14 12  1  1  0  0  0
 13 15  1  0  0  0  0
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 18 19  1  0  0  0  0
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 20 21  1  0  0  0  0
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  6  8  1  0  0  0  0
 13 14  1  0  0  0  0
 16 18  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006471

>  <SMILES>
O=C(c1cccc(Cl)n1)N1C[C@H]2CN(CC3CC3)C(=O)[C@H]2C1

$$$$
SWF006472
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.9504   -0.7734   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9371   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    5.2495    0.7577   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5575   -0.7416   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
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  9 14  1  0  0  0  0
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 10 16  2  0  0  0  0
 11 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 13 18  1  0  0  0  0
 14 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006472

>  <SMILES>
CCC(=O)N1CCC(C(=O)NCC2CC2)(n2cccn2)CC1

$$$$
SWF006473
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  1  0  0  0  0
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 11 14  1  0  0  0  0
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 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5  7  1  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006473

>  <SMILES>
CCc1ccc(C(=O)N2C[C@H]3CN(CC4CC4)C(=O)[C@H]3C2)cn1

$$$$
SWF006474
Actelion Java MolfileCreator 1.0

 22 23  0  0  0  0  0  0  0  0999 V2000
    6.9757    0.5933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
M  END
>  <HTSID>
SWF006474

>  <SMILES>
COCCNC(=O)C1(Nc2nccs2)CCN(C(C)C)CC1

$$$$
SWF006475
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.4505    3.6375   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3322    2.4240   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2549    0.7418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.1974    1.5240   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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 11 15  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
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 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006475

>  <SMILES>
CCc1ccc(C(=O)N2CCC3(CC3C(=O)N3CCOCC3)C2)cn1

$$$$
SWF006476
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
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 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006476

>  <SMILES>
CCc1ccc(C(=O)N2CCOCC3(CN(CC)C(=O)CO3)C2)cn1

$$$$
SWF006477
Actelion Java MolfileCreator 1.0

 26 30  0  0  1  0  0  0  0  0999 V2000
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 11 16  1  0  0  0  0
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 12 16  1  0  0  0  0
 18 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006477

>  <SMILES>
O=C([C@H]1[C@@H]2COC[C@@H]21)N1CCOC2(CCN(Cc3ccncc3)CC2)C1

$$$$
SWF006478
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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  3  5  1  0  0  0  0
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 14 15  1  0  0  0  0
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 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
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 20 24  1  0  0  0  0
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 24 26  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006478

>  <SMILES>
CN(C)C(=O)C1(Nc2ccccc2)CCN(C(=O)c2ccnn2C)CC1

$$$$
SWF006479
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 11 14  1  0  0  0  0
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 27 28  1  0  0  0  0
 10 13  1  0  0  0  0
 14 17  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006479

>  <SMILES>
COc1ccc(CN2Cc3ncnn3CC(C(=O)N3CCN(C)CC3)C2)cc1

$$$$
SWF006480
Actelion Java MolfileCreator 1.0

 21 24  0  0  1  0  0  0  0  0999 V2000
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  4  5  1  0  0  0  0
 10 12  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF006480

>  <SMILES>
Cc1noc([C@@H]2CC[C@@H]3[C@@H](CCN3Cc3ccsc3)O2)n1

$$$$
SWF006481
Actelion Java MolfileCreator 1.0

 28 31  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006481

>  <SMILES>
CCn1cc(CN2CCC3(CC2)CC[C@@]2(C(=O)NC)CN(C(C)=O)C[C@@H]32)cn1

$$$$
SWF006482
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.3956   -4.8147   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006482

>  <SMILES>
COc1cnccc1C(=O)N1CC2OCCN(C(C)C)C2C1

$$$$
SWF006483
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006483

>  <SMILES>
CC(C)CNC(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF006484
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006484

>  <SMILES>
CCN1CC2(CCN(C(=O)c3ccccc3)CC2)c2ccccc21

$$$$
SWF006485
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006485

>  <SMILES>
Cc1noc(C)c1C(=O)N1CC2OCCN(Cc3ccncc3)C2C1

$$$$
SWF006486
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006486

>  <SMILES>
COc1ccccc1CN1CC2Cc3nnc(C(=O)Nc4ccccc4)n3CC2C1

$$$$
SWF006487
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.6636   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.0055   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    0.7976   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6394    1.7681   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 21 25  1  0  0  0  0
 22 26  2  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006487

>  <SMILES>
Cc1ccc(CN2CCC(Nc3ccccc3)(C(=O)NC(C)C)CC2)s1

$$$$
SWF006488
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
    5.1962   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7942    2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9282    3.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4282    4.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4282    4.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  1  0  0  0  0
 15 19  2  0  0  0  0
 16 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 12 16  1  0  0  0  0
 19 21  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006488

>  <SMILES>
COCCNC(=O)C1(Nc2ccccc2)CCN(C(=O)C2CC2)CC1

$$$$
SWF006489
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7670    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0349    1.4339   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2575    2.4088   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7426    1.7509   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  9  5  1  6  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 11 17  2  0  0  0  0
 14 18  1  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 12 17  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006489

>  <SMILES>
O=C(c1cnccn1)N1CCOCC2(CCN(c3ncccn3)C2)C1

$$$$
SWF006490
Actelion Java MolfileCreator 1.0

 26 28  0  0  1  0  0  0  0  0999 V2000
    8.7153    4.1046   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.2153    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6935    3.8967   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.2208    3.1341   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7980    2.9022   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -3.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  6  0  0  0
 12 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  2  0  0  0  0
 21 24  1  0  0  0  0
 22 25  2  0  0  0  0
 24 26  1  0  0  0  0
  4  6  1  0  0  0  0
 13 15  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006490

>  <SMILES>
COCCO[C@@H]1CCN(C(=O)/C=C/c2cccs2)[C@H]1Cc1ccccc1

$$$$
SWF006491
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    1.2990   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5490    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7500   -2.0490   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  1  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 19 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 15 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006491

>  <SMILES>
Cn1cc(C2CC(=O)NC23CCN(S(=O)(=O)C2CC2)CC3)cn1

$$$$
SWF006492
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.9757    0.5933   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0622    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6449    1.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1667    1.9945   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1449    2.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  4  6  1  0  0  0  0
 14 16  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006492

>  <SMILES>
COCCNC(=O)C1(Nc2nccs2)CCN(Cc2ccccc2C)CC1

$$$$
SWF006493
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 17  1  0  0  0  0
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 10 11  1  0  0  0  0
 14 17  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006493

>  <SMILES>
CC(=O)N1CCC(Nc2ccn(C)n2)(C(=O)N2CCCC2)CC1

$$$$
SWF006494
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006494

>  <SMILES>
COc1cc(C(=O)N2CC[C@@H](OC)[C@H](Cc3ccccc3)C2)on1

$$$$
SWF006495
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
   -2.5981   -1.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 22 24  1  0  0  0  0
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 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006495

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(Cc2cn[nH]c2)CC1

$$$$
SWF006496
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 11 14  2  0  0  0  0
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 19 21  1  0  0  0  0
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 24 27  2  0  0  0  0
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 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006496

>  <SMILES>
Cc1ccccc1CN1CCC(Nc2ccccc2)(C(=O)NC(C)C)CC1

$$$$
SWF006497
Actelion Java MolfileCreator 1.0

 25 26  0  0  0  0  0  0  0  0999 V2000
    6.9282    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006497

>  <SMILES>
COCCC(=O)N1CCC(Nc2ccccc2)(C(=O)NC(C)C)CC1

$$$$
SWF006498
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 30 32  1  0  0  0  0
M  END
>  <HTSID>
SWF006498

>  <SMILES>
COc1cnccc1C(=O)N1CCC2(CCc3nc(-c4ccccc4)cc(=O)n3CC2)C1

$$$$
SWF006499
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006499

>  <SMILES>
COc1cccc(NC2(C(=O)N(C)C)CCN(Cc3cc(C)on3)CC2)c1

$$$$
SWF006500
Actelion Java MolfileCreator 1.0

 23 24  0  0  0  0  0  0  0  0999 V2000
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 21 23  2  0  0  0  0
M  END
>  <HTSID>
SWF006500

>  <SMILES>
CCCS(=O)(=O)N1CCC(Nc2ccnn2C)(C(=O)NC)CC1

$$$$
SWF006501
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006501

>  <SMILES>
CN1CCC(Nc2ccccc2)(C(=O)Nc2cccnc2)CC1

$$$$
SWF006502
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
  9 14  1  6  0  0  0
 11 15  1  0  0  0  0
 13 16  1  1  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006502

>  <SMILES>
CO[C@@H]1CCN(C(=O)c2ncn(C)n2)C[C@H]1Cc1ccccc1

$$$$
SWF006503
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    4.3132    4.7521   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9010    3.9431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4942    3.0295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8955    4.0476   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4997    2.9250   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5646    3.3045   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3955    4.9136   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0930    2.0115   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6753    1.3070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4782    3.7112   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3736    4.7057   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006503

>  <SMILES>
CN(C)C(=O)C1CCC2(CCN(C(=O)C3CCOC3)CC2)O1

$$$$
SWF006504
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    5.1962    1.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.5981    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.8147   -2.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3092   -1.7319   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  6  7  1  0  0  0  0
 15 16  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006504

>  <SMILES>
CC1CN(C(=O)Cc2ccc(F)cn2)CCC12CCC(C(=O)N(C)C)O2

$$$$
SWF006505
Actelion Java MolfileCreator 1.0

 25 27  0  0  1  0  0  0  0  0999 V2000
    5.2318    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8195    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.8141    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.3141    3.0865   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.5815    0.0675   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  1  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  1  0  0  0  0
 19 22  2  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006505

>  <SMILES>
COCCO[C@@H]1CCN(C(=O)c2ncn(C)n2)[C@H]1Cc1ccccc1

$$$$
SWF006506
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
    6.4768   -2.3950   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    4.9953   -2.6297   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0143   -0.9947   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9346   -1.5690   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    8.4632   -0.6064   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1974    0.2634   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -2.2500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3330   -1.7050   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  2  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  6  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 17 20  2  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 23 25  1  0  0  0  0
 23 26  2  0  0  0  0
 10 11  1  0  0  0  0
 12 13  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006506

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(S(=O)(=O)c2cn(C)cn2)C1

$$$$
SWF006507
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
    6.8900    4.1521   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4833    3.2386   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  5  8  2  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 23 26  2  0  0  0  0
 24 27  2  0  0  0  0
  6  8  1  0  0  0  0
 15 16  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006507

>  <SMILES>
CNC(=O)C1(Nc2cccc(F)c2)CCN(C(=O)Cc2ccccc2C)C1

$$$$
SWF006508
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    9.8456   -3.7589   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.6888   -2.2671   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3185   -1.6570   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9023   -1.3855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1617   -0.1652   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2499   -2.7097   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7455    0.1063   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3752    0.7164   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8976    0.6423   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7606   -2.5306   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9590    0.9880   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4781    0.1575   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  9 12  1  0  0  0  0
 13 10  1  1  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  3  0  0  0  0
 22 25  1  0  0  0  0
 23 26  1  0  0  0  0
  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006508

>  <SMILES>
Cc1cc(=O)n2c(n1)CCC1(CCN(C(=O)C3(C#N)CCCC3)C1)CC2

$$$$
SWF006509
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    3.4997    2.9250   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0820    2.2205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7511    1.4774   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820    3.0865   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9595    1.6637   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 12 13  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006509

>  <SMILES>
CCO[C@H]1CCN(C(=O)c2cc[nH]n2)[C@H]1Cc1cccnc1

$$$$
SWF006510
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    9.5192   -5.6119   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5155   -4.4972   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7692   -6.9110   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1452   -5.1073   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3019   -6.5991   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8461   -4.3573   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
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 10  7  1  6  0  0  0
  8 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  1  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  4  5  1  0  0  0  0
 10 11  1  0  0  0  0
 14 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006510

>  <SMILES>
C[C@@H]1CN(C(=O)C2CC(F)(F)C2)C[C@]12CCN(c1ccsc1)C2=O

$$$$
SWF006511
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.9568   -5.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -5.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006511

>  <SMILES>
CS(=O)(=O)NC1CC2(CCN(C(=O)c3ccccc3)CC2)C1

$$$$
SWF006512
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    6.6961   -0.7500   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9461    0.5490   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8971   -3.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  7  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  8 13  1  0  0  0  0
 10 14  2  0  0  0  0
 10 15  1  0  0  0  0
 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
 13 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006512

>  <SMILES>
CN1CCC2(CN(C(=O)C3CC(O)C3)CC(F)(F)C2)C1=O

$$$$
SWF006513
Actelion Java MolfileCreator 1.0

 23 24  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.9641    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  2  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006513

>  <SMILES>
C[C@H]1[C@H](CCNS(C)(=O)=O)COCCN1C(=O)c1ccccn1

$$$$
SWF006514
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.0622    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 11 16  1  0  0  0  0
 13 17  1  0  0  0  0
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 16 20  1  0  0  0  0
 17 21  1  0  0  0  0
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 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
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 25 27  2  0  0  0  0
 26 28  2  0  0  0  0
 10 13  1  0  0  0  0
 12 16  1  0  0  0  0
 18 21  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <HTSID>
SWF006514

>  <SMILES>
CC1CCC(C(=O)N2CCC3OCCCC3(COCc3ccncc3)C2)CC1

$$$$
SWF006515
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10  6  1  6  0  0  0
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  8 13  2  0  0  0  0
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 20 22  1  0  0  0  0
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 13 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006515

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@@H]2CCCO[C@@H]2[C@H](N(C)C)C1

$$$$
SWF006516
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    6.9282    0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 18 20  1  0  0  0  0
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 21 23  2  0  0  0  0
  7  8  1  0  0  0  0
 13 14  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006516

>  <SMILES>
CCN1CCC2(CCN(C(=O)Cc3ccccc3)CC2)CC1=O

$$$$
SWF006517
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 10 12  1  0  0  0  0
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 14 15  1  0  0  0  0
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 16 19  1  6  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
  4  6  1  0  0  0  0
 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006517

>  <SMILES>
Cc1nc(C(=O)N2CCC3(CC2)OCC(=O)NC3C)cs1

$$$$
SWF006518
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7634   -1.6728   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.5360    0.4908   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8147    0.0296   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006518

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CC(=O)N(c3cncnc3)C2)C1

$$$$
SWF006519
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3425   -2.0159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206   -1.8080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
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  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
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 17 20  1  0  0  0  0
 18 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 16 19  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006519

>  <SMILES>
O=C1NC[C@@H](COc2cccnc2)[C@]12CCN(C1CCC1)C2

$$$$
SWF006520
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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   10.3610   -7.8478   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
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 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 14  1  0  0  0  0
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 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006520

>  <SMILES>
Cn1cnc(S(=O)(=O)N2CCc3c(COCC4CC4)cncc3C2)c1

$$$$
SWF006521
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
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 17 19  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006521

>  <SMILES>
COc1cccc(CNC2CCC3(CCC(=O)N3Cc3ccccc3)CC2)c1

$$$$
SWF006522
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    1.6101    0.0235   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  6  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  7 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  2  0  0  0  0
 11 15  2  0  0  0  0
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 17 18  1  0  0  0  0
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 19 21  1  0  0  0  0
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 21 23  2  0  0  0  0
 13 16  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006522

>  <SMILES>
CN(C)C(=O)C1(n2cccn2)CCCN(Cc2ccccc2)C1

$$$$
SWF006523
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 20 22  1  0  0  0  0
  9 10  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006523

>  <SMILES>
CCNC(=O)c1ncn2c1CCC(C(=O)NC1CCCC1)C2

$$$$
SWF006524
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2221   -2.5537   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3404   -3.7672   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7139   -2.7104   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   10.5278   -7.1350   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 13 15  1  0  0  0  0
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 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006524

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccccc3)CC2)CN1CC1CC1

$$$$
SWF006525
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
    6.4833    3.2386   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.0875    2.1160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
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 10 13  1  0  0  0  0
 11 14  1  1  0  0  0
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 14 16  1  0  0  0  0
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 16 20  1  0  0  0  0
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 18 22  2  0  0  0  0
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 23 24  1  0  0  0  0
  5  6  1  0  0  0  0
 11 13  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006525

>  <SMILES>
CC(C)N(C)[C@@H]1CCN(Cc2cccnc2)[C@H]1Cc1cnn(C)c1

$$$$
SWF006526
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.5665   -0.1399   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
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 14 15  1  0  0  0  0
 18 19  2  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006526

>  <SMILES>
O=C(NC1CCC1)C1=NOC2(CCN(C(=O)/C=C/c3cccs3)CC2)C1

$$$$
SWF006527
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    7.8545    0.3295   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 10 15  1  0  0  0  0
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 13 17  1  0  0  0  0
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 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
 10 12  1  0  0  0  0
 16 19  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006527

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)c1cnn3ccccc13)C2

$$$$
SWF006528
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 16 18  1  0  0  0  0
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 18 20  1  0  0  0  0
 19 21  1  1  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
  6  8  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006528

>  <SMILES>
CN(C)C1CCOC2(CCN(C(=O)c3cccc(F)c3)CC2)C1

$$$$
SWF006529
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.6456   -0.9067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -3.2215    1.6160   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  2  3  2  0  0  0  0
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 14 12  1  1  0  0  0
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 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 15 17  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006529

>  <SMILES>
CN1CCC2(CCCN(C(=O)Cc3cccc(F)c3)C2)C1=O

$$$$
SWF006530
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
   11.6282    1.2478   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7465    0.0342   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2547    0.1910   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3566   -1.3361   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6446    1.5613   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3730   -1.0225   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6066   -2.6351   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8238   -1.6480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1528    1.7181   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8812   -0.8657   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6103   -3.7498   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.2711    0.5046   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5211    1.8037   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006530

>  <SMILES>
O=C(N1CCCC1)N1CCC2(CC1)CC(OCc1ccccn1)CO2

$$$$
SWF006531
Actelion Java MolfileCreator 1.0

 22 25  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990    1.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
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 13 15  1  0  0  0  0
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 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006531

>  <SMILES>
O=C(c1cscn1)N1CCC2(C1)CN(C(=O)c1cc[nH]n1)C2

$$$$
SWF006532
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 10 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 11 12  1  0  0  0  0
 14 16  1  0  0  0  0
 17 18  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006532

>  <SMILES>
O=C(C1CCOC1)N1CCOCC2(CCC(CN3CCOCC3)O2)C1

$$$$
SWF006533
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  0  0  0  0
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  9 16  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  2  0  0  0  0
 14 19  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 16  1  0  0  0  0
 13 18  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006533

>  <SMILES>
COc1cnccc1C(=O)N1CCCC2(CCN(C)CC2)C1

$$$$
SWF006534
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.4209    3.2071   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4209    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
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 11 14  2  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 12 14  1  0  0  0  0
 16 17  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006534

>  <SMILES>
O=C(NC1CC2(CCN(C(=O)c3ccccc3)CC2)C1)c1cccnc1

$$$$
SWF006535
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8404   -1.6871   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6521    0.1050   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8147   -1.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8333   -1.8065   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5984    0.4282   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5456   -1.1047   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4411   -0.1102   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  1  0  0  0
  4  8  1  0  0  0  0
  4  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  5  9  1  0  0  0  0
 13 14  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006535

>  <SMILES>
CCN1CCC2(CCCN(C(=O)c3ccccc3)CC2)C1=O

$$$$
SWF006536
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    2.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1097    2.0933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007    3.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7788    2.8364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2788    3.7024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
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  5  9  1  0  0  0  0
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  7 11  1  0  0  0  0
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  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10 13  1  0  0  0  0
 11 12  1  0  0  0  0
 17 19  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006536

>  <SMILES>
O=C(c1ccoc1)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF006537
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   10.2277   -5.4753   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8011   -5.0118   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4892   -3.5445   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6864   -6.0155   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6040   -2.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0627   -3.0810   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2192   -5.7036   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.2921   -1.0736   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7508   -1.6138   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4692   -7.0026   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.8655   -0.6101   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8692    0.5046   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4952   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1192    1.8037   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6520    1.4918   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8971   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 13  1  0  0  0  0
 11 12  2  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006537

>  <SMILES>
CCOCCC1CCOC12CCN(C(=O)C1CC=CC1)CC2

$$$$
SWF006538
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9659   -0.2412   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2588   -1.4659   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -0.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2247   -2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0908   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9568   -2.2071   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -2.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8228   -3.7071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6318   -4.2949   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0138   -4.2949   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3228   -5.2459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3228   -5.2459   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7350   -6.0550   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
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 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <HTSID>
SWF006538

>  <SMILES>
Cc1csc(CN2CCC3(CC2)CC(NS(C)(=O)=O)C3)n1

$$$$
SWF006539
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
   -3.3311    1.7658   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3800    2.0749   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6369    1.4057   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1721    3.0530   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6858    1.7147   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2210    3.3620   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0573    1.0456   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4779    2.6929   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1506    0.0675   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0084    1.3546   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7515    0.6855   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2163    2.3328   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9105    1.9727   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
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  5  7  1  0  0  0  0
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  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  6  0  0  0
 13 16  1  0  0  0  0
 13 17  1  0  0  0  0
 15 18  1  0  0  0  0
 15 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
  6  8  1  0  0  0  0
 14 16  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006539

>  <SMILES>
C=CCN1CCCC12CCCN(C(=O)c1cccc(Cl)n1)C2

$$$$
SWF006540
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    4.3301    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1712    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7570    2.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
 20 23  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006540

>  <SMILES>
c1cncc(CN2CC3(CC(OCC4CCOCC4)CCO3)C2)c1

$$$$
SWF006541
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  8  9  1  0  0  0  0
 13 14  1  0  0  0  0
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M  END
>  <HTSID>
SWF006541

>  <SMILES>
CC1CC1C(=O)N1CCC2(CC1)CC(NS(C)(=O)=O)C2

$$$$
SWF006542
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 21 23  1  0  0  0  0
  8 10  1  0  0  0  0
 19 22  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006542

>  <SMILES>
Cn1cc(C[C@H]2[C@H](O)CCN2C(=O)CCc2ccccc2)cn1

$$$$
SWF006543
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 17 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006543

>  <SMILES>
COc1cccc(CN2CCC3(CCN(C(=O)N4CCCC4)C3)C2=O)c1

$$$$
SWF006544
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 12 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF006544

>  <SMILES>
O=C(CC1(O)CCC1)N1CCOC2(COCCN(c3cnccn3)C2)C1

$$$$
SWF006545
Actelion Java MolfileCreator 1.0

 27 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006545

>  <SMILES>
CCc1ccc(C(=O)N2CCCC3(COCCN(CC(=O)NC)C3)C2)cn1

$$$$
SWF006546
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 10 15  2  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  6  9  1  0  0  0  0
 12 15  1  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <HTSID>
SWF006546

>  <SMILES>
COCCN1CCC2(C1)CN(C(=O)c1ccc(OC)cc1C)C2

$$$$
SWF006547
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006547

>  <SMILES>
O=S(=O)(NC1CC2(CCN(Cc3ccccn3)CC2)C1)c1ccccc1

$$$$
SWF006548
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006548

>  <SMILES>
O=C1CC2(CCN(C(=O)c3ccnnc3)CC2)CN1Cc1ccncc1

$$$$
SWF006549
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006549

>  <SMILES>
CC1CC(C(=O)N2CCC3(CCC(=O)N3CCN(C)C)CC2)C1

$$$$
SWF006550
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006550

>  <SMILES>
Cn1nccc1C(=O)N1CC[C@]2(C1)C[C@@H](Nc1ncccn1)C2

$$$$
SWF006551
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006551

>  <SMILES>
Cc1ncsc1CN1CC[C@]2(CCC[C@H]2C(=O)N2CCCCO2)C1

$$$$
SWF006552
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006552

>  <SMILES>
Cc1ccccc1CC(=O)N1CCC2(CCn3c2nnc(-c2ccccc2)c3=O)C1

$$$$
SWF006553
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006553

>  <SMILES>
Cn1nccc1C(=O)N1CCC2(CCc3nnc(C(=O)NC4CCCC4)n3C2)CC1

$$$$
SWF006554
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006554

>  <SMILES>
C=CCN1CCOC2CN(C(=O)C3(C#N)CCCC3)CCC2C1

$$$$
SWF006555
Actelion Java MolfileCreator 1.0

 25 29  0  0  0  0  0  0  0  0999 V2000
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 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  1  0  0  0  0
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  8  9  1  0  0  0  0
 10 11  2  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006555

>  <SMILES>
O=C(NC1CC1)c1nnc2n1CC1(CC2)CCN(C(=O)C2CC2)CC1

$$$$
SWF006556
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    3.8228   -1.7071   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9568   -1.2071   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 13 15  1  0  0  0  0
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 18 20  1  0  0  0  0
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 20 22  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006556

>  <SMILES>
O=C(C1CC(F)C1)N1C[C@@H]2CCN(Cc3cccnc3)[C@@H]2C1

$$$$
SWF006557
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    0.5920    5.2023   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0042    4.3933   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9903    4.4978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.5781    3.6888   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1768    2.6707   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7245    0.7866   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 12 10  1  6  0  0  0
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 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006557

>  <SMILES>
CN(C)C(=O)[C@@H]1CCC[C@]12CCN(Cc1cncc(Cl)c1)C2

$$$$
SWF006558
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2321   -1.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2321    0.3660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -2.1383   -0.8004   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3293   -2.2016   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.5653   -3.8660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  6  4  1  1  0  0  0
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  9 10  1  1  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
  8  9  1  0  0  0  0
 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006558

>  <SMILES>
CS(=O)(=O)N[C@H]1C[C@]2(CCN(C(=O)c3cccnc3)C2)C1

$$$$
SWF006559
Actelion Java MolfileCreator 1.0

 26 29  0  0  0  0  0  0  0  0999 V2000
    6.2983   -0.5228   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3038   -0.6274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7160    0.1817   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8970   -1.5409   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1227    1.0952   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7215    0.0771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9025   -1.6454   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1172    1.1997   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  2  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
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 10 14  1  0  0  0  0
 10 15  1  0  0  0  0
 12 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
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 21 22  2  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006559

>  <SMILES>
CN1CC(=O)N(c2ccccc2)CC12CCN(C(=O)c1cccnc1)C2

$$$$
SWF006560
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6750    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0570    1.5878   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3660    2.5388   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
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  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  2  0  0  0  0
  9 13  1  6  0  0  0
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 11 15  2  0  0  0  0
 13 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
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 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  9 10  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006560

>  <SMILES>
O=C(c1ccnnc1)N1CCC2(CCCN(c3ncccn3)C2)C1

$$$$
SWF006561
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    7.4930    1.8638   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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 14 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF006561

>  <SMILES>
CCCN1CCOC2(COCCN(C(=O)C3(F)CCC3)C2)C1

$$$$
SWF006562
Actelion Java MolfileCreator 1.0

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M  END
>  <HTSID>
SWF006562

>  <SMILES>
CNC(=O)CC1CC2(CCN(C(=O)Nc3cccc(C)c3)CC2)Oc2ccccc21

$$$$
SWF006563
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006563

>  <SMILES>
O=C1N(c2ncccn2)CC12CCCN(CC1CCCCC1)C2

$$$$
SWF006564
Actelion Java MolfileCreator 1.0

 27 30  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006564

>  <SMILES>
C[C@H]1CC[C@H](C(=O)N2CCCC3(COCCN(c4cccnc4)C3)C2)CC1

$$$$
SWF006565
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006565

>  <SMILES>
COc1ccc(CN2CC3(CCN(C(=O)c4cc(C5CC5)on4)CC3)CC2=O)cc1

$$$$
SWF006566
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
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 20 21  1  0  0  0  0
M  END
>  <HTSID>
SWF006566

>  <SMILES>
CCN1CCN(C)C2(CCN(Cc3cnn(C)c3)CC2)C1=O

$$$$
SWF006567
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006567

>  <SMILES>
COc1ccc(CC(=O)N2CCOCC3(CCN(C)C3)C2)cc1

$$$$
SWF006568
Actelion Java MolfileCreator 1.0

 25 27  0  0  0  0  0  0  0  0999 V2000
   10.3367   -2.6884   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006568

>  <SMILES>
CC(C)CN1CCOC2(CCCN(C(=O)c3cccc(Cl)n3)CC2)C1

$$$$
SWF006569
Actelion Java MolfileCreator 1.0

 21 23  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006569

>  <SMILES>
CCOC1COC2(CCCN(C(=O)c3csc(C)n3)C2)C1

$$$$
SWF006570
Actelion Java MolfileCreator 1.0

 21 23  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006570

>  <SMILES>
CS(=O)(=O)N[C@H]1C[C@@]2(CCN(Cc3cncc(Cl)c3)C2)C1

$$$$
SWF006571
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
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 12 13  1  0  0  0  0
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M  END
>  <HTSID>
SWF006571

>  <SMILES>
Cn1cc(N2C(=O)CC[C@@H]3[C@H]2CCN3Cc2cccnc2)cn1

$$$$
SWF006572
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    2.5981    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  7  8  1  0  0  0  0
 12 13  1  0  0  0  0
 16 18  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006572

>  <SMILES>
O=C1COC2(COCCN(c3ncccn3)C2)CN1CC1CC1

$$$$
SWF006573
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006573

>  <SMILES>
CCc1ccc(C(=O)N2CCCC3(CCN(C)CC3)C2)cn1

$$$$
SWF006574
Actelion Java MolfileCreator 1.0

 24 26  0  0  1  0  0  0  0  0999 V2000
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 22 24  1  0  0  0  0
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M  END
>  <HTSID>
SWF006574

>  <SMILES>
COCCO[C@H]1CCN(C(=O)c2ccoc2)[C@H]1Cc1ccccc1

$$$$
SWF006575
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  9  1  1  0  0  0
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M  END
>  <HTSID>
SWF006575

>  <SMILES>
O=C1C[C@@H]2[C@H](CCN2Cc2ccc(F)cc2)N1Cc1ccncc1

$$$$
SWF006576
Actelion Java MolfileCreator 1.0

 34 38  0  0  0  0  0  0  0  0999 V2000
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 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
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 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 21 24  2  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 24 27  1  0  0  0  0
 25 28  2  0  0  0  0
 26 29  2  0  0  0  0
 26 30  1  0  0  0  0
 27 31  2  0  0  0  0
 29 32  1  0  0  0  0
 30 33  2  0  0  0  0
 32 34  2  0  0  0  0
  7  9  1  0  0  0  0
 15 16  1  0  0  0  0
 20 22  1  0  0  0  0
 28 31  1  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <HTSID>
SWF006576

>  <SMILES>
Cn1c(C(=O)N2CCOC3(C2)C(=O)N(Cc2cccnc2)CC3c2ccccc2)cccc1=O

$$$$
SWF006577
Actelion Java MolfileCreator 1.0

 23 25  0  0  1  0  0  0  0  0999 V2000
    2.5981   -2.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5380    0.9781   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9393    0.1691   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5326    1.0827   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    8.2447    2.1825   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  3  1  6  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  8 11  1  6  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 20 23  1  0  0  0  0
  7  8  1  0  0  0  0
 11 12  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006577

>  <SMILES>
Cc1nocc1C(=O)N1CC[C@@H]2[C@H]1CCC(=O)N2CCN(C)C

$$$$
SWF006578
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    5.9441    2.7635   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3508    1.8499   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7631    1.0409   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3454    1.7454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685    1.1454   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1698    0.1274   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8454    0.8794   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0145    2.4885   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5820   -0.6817   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8235    1.0873   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.9280    2.0818   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6808    1.2024   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5875   -0.5771   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5116   -0.4067   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.7321   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  9 13  1  6  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  6  0  0  0
 18 19  1  0  0  0  0
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 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 10 14  1  0  0  0  0
 11 12  1  0  0  0  0
 16 17  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006578

>  <SMILES>
O=C(C1CCOC1)N1CCC[C@@]2(C[C@H](OCc3ccccn3)CO2)C1

$$$$
SWF006579
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
    2.1104    1.5540   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535    0.8849   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6456   -0.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8046    1.1939   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.3147   -0.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  1  6  0  0  0
  6 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 15 19  1  0  0  0  0
 18 20  1  0  0  0  0
 19 21  2  0  0  0  0
 20 22  2  0  0  0  0
  9 11  1  0  0  0  0
 13 16  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006579

>  <SMILES>
CO[C@H]1CCN(C(=O)C2CCOCC2)[C@H]1Cc1ccccc1

$$$$
SWF006580
Actelion Java MolfileCreator 1.0

 26 29  0  0  1  0  0  0  0  0999 V2000
    5.1753    0.2319   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1808    0.3364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.7026    0.9945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    4.4252   -0.8135   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3425   -2.0159   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206   -1.8080   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9412   -3.0340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5235   -3.7385   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660    0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0000   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8660   -2.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.2635   -4.9985   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  1  0  0  0
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  8 11  1  0  0  0  0
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 10 13  1  0  0  0  0
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 13 15  2  0  0  0  0
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 14 18  1  0  0  0  0
 16 19  1  0  0  0  0
 16 20  2  0  0  0  0
 17 21  1  0  0  0  0
 18 22  2  0  0  0  0
 19 23  2  0  0  0  0
 19 24  1  0  0  0  0
 20 25  1  0  0  0  0
 21 26  2  0  0  0  0
  5  6  1  0  0  0  0
 10 11  1  0  0  0  0
 22 26  1  0  0  0  0
 23 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006580

>  <SMILES>
Cc1nocc1C(=O)N1CC[C@]2(C1)C(=O)NC[C@@H]2COc1ccccn1

$$$$
SWF006581
Actelion Java MolfileCreator 1.0

 27 29  0  0  1  0  0  0  0  0999 V2000
    2.5017   12.5150   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2517   11.2159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5017    9.9169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7517   11.2159   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2517    8.6178   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5017    9.9169   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7517    8.6178   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5017    7.3188   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7517    6.0198   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2517    6.0198   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5017    4.7207   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    5.0989    2.0480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    9.0933   -0.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
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  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
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  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 16 14  1  6  0  0  0
 17 15  1  6  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
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 23 24  1  0  0  0  0
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 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
  6  7  1  0  0  0  0
 16 17  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006581

>  <SMILES>
C=CCOCC1CNC(=O)[C@H]2CCN(C(=O)Cc3ccc(F)cn3)CC[C@@H]12

$$$$
SWF006582
Actelion Java MolfileCreator 1.0

 28 31  0  0  0  0  0  0  0  0999 V2000
    3.4641   -0.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  6  9  1  0  0  0  0
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 26 28  1  0  0  0  0
  9 11  1  0  0  0  0
 17 20  1  0  0  0  0
 18 19  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006582

>  <SMILES>
Cc1ccc(OCC(=O)N2CCC3(CC2)COC(CN2CCC(O)C2)C3)cc1

$$$$
SWF006583
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    3.4641    2.5000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    4.3301    1.0000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    6.1097    2.0933   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3007    3.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
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  6 10  1  0  0  0  0
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  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
  9 15  1  0  0  0  0
  9 16  1  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 16 19  1  0  0  0  0
 17 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  2  0  0  0  0
 25 27  2  0  0  0  0
 10 14  1  0  0  0  0
 11 13  2  0  0  0  0
 18 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006583

>  <SMILES>
Cn1nccc1C(=O)N1CCC2OCCCC2(COCc2ccncc2)C1

$$$$
SWF006584
Actelion Java MolfileCreator 1.0

 23 26  0  0  1  0  0  0  0  0999 V2000
    5.8961   -4.8841   -0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.3028   -3.9706   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    7.7041   -2.9525   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1218   -2.2480   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.7321   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 12 10  1  6  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 19 21  1  0  0  0  0
 20 22  2  0  0  0  0
 21 23  2  0  0  0  0
  6  7  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <HTSID>
SWF006584

>  <SMILES>
Clc1cncc(CN2CC[C@]3(C2)C[C@@H](Nc2ncccn2)C3)c1

$$$$
SWF006585
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0349   -4.4431   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6282   -3.5295   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    4.2160   -2.7205   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    2.4472   -5.2521   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7562   -6.2031   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8092   -1.8070   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 14  1  0  0  0  0
 11 12  2  0  0  0  0
 17 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006585

>  <SMILES>
Cn1ncnc1C(=O)N1CCC2(CC1)COC(CN1CCC(O)C1)C2

$$$$
SWF006586
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
    2.5981   -0.7500   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  4  7  2  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  8 13  2  0  0  0  0
  9 14  1  6  0  0  0
 10 15  1  6  0  0  0
 11 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
  9 10  1  0  0  0  0
 13 16  1  0  0  0  0
 18 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006586

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@@H]2CN(c3ncccn3)CCO[C@@H]2C1

$$$$
SWF006587
Actelion Java MolfileCreator 1.0

 35 39  0  0  0  0  0  0  0  0999 V2000
    5.1681   -0.7788   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 13 16  1  0  0  0  0
 21 26  1  0  0  0  0
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 31 32  1  0  0  0  0
M  END
>  <HTSID>
SWF006587

>  <SMILES>
COCc1ccc(C(=O)N2CCOC3(C2)C(=O)N(Cc2cccnc2)CC3c2ccccc2)cc1

$$$$
SWF006588
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.1808    0.3364   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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 22 24  2  0  0  0  0
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 18 21  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006588

>  <SMILES>
c1ccc(CN2CCOC3CC(COc4ccccn4)CC32)nc1

$$$$
SWF006589
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
    2.8535    0.8849   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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M  END
>  <HTSID>
SWF006589

>  <SMILES>
C[C@H]1CC[C@H](C(=O)N2C[C@H]3CN(CC4CC4)C(=O)[C@H]3C2)CC1

$$$$
SWF006590
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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 10  6  1  6  0  0  0
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 13 16  1  0  0  0  0
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M  END
>  <HTSID>
SWF006590

>  <SMILES>
Cc1ccccc1C(=O)N1C[C@@H]2[C@H](CC(=O)NC3CC3)CO[C@@H]2C1

$$$$
SWF006591
Actelion Java MolfileCreator 1.0

 32 36  0  0  0  0  0  0  0  0999 V2000
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 21 24  1  0  0  0  0
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 30 32  2  0  0  0  0
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 13 14  1  0  0  0  0
 18 20  1  0  0  0  0
 26 29  1  0  0  0  0
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M  END
>  <HTSID>
SWF006591

>  <SMILES>
O=C(C1CC(F)(F)C1)N1CCOC2(C1)C(=O)N(Cc1cccnc1)CC2c1ccccc1

$$$$
SWF006592
Actelion Java MolfileCreator 1.0

 26 28  0  0  0  0  0  0  0  0999 V2000
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 12 14  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006592

>  <SMILES>
CN(C)CCN1C(=O)CCC12CCN(C(=O)NCc1ccccc1)CC2

$$$$
SWF006593
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006593

>  <SMILES>
Cn1cnc(C(=O)N2C[C@H](C(=O)N3CCCC3)[C@@H]3CCO[C@@H]3C2)n1

$$$$
SWF006594
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006594

>  <SMILES>
COCCN1CC[C@]2(CN(Cc3ccccc3)C[C@H]2C)C1=O

$$$$
SWF006595
Actelion Java MolfileCreator 1.0

 30 34  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006595

>  <SMILES>
O=C(NC1CC1)C1=CC2(CCN(C(=O)Cc3ccc(F)cn3)CC2)c2ccccc21

$$$$
SWF006596
Actelion Java MolfileCreator 1.0

 22 24  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006596

>  <SMILES>
Cc1ncnc(C(=O)N2CC[C@@H]3CN(C)CCO[C@@H]3C2)c1C

$$$$
SWF006597
Actelion Java MolfileCreator 1.0

 25 28  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006597

>  <SMILES>
c1ccc(CN2CC[C@@H]3CN(Cc4cccnc4)CCO[C@@H]3C2)nc1

$$$$
SWF006598
Actelion Java MolfileCreator 1.0

 22 25  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006598

>  <SMILES>
CO[C@H]1CO[C@]2(CCCN(C(=O)c3cc(C4CC4)on3)C2)C1

$$$$
SWF006599
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006599

>  <SMILES>
COCCN1C(=O)CCC12CCCN(C(=O)c1cc[nH]n1)CC2

$$$$
SWF006600
Actelion Java MolfileCreator 1.0

 27 31  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006600

>  <SMILES>
Cc1cccc(CN2CCC3(CCN(C(=O)[C@H]4[C@@H]5COC[C@@H]54)CC3)C2=O)c1

$$$$
SWF006601
Actelion Java MolfileCreator 1.0

 29 32  0  0  1  0  0  0  0  0999 V2000
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M  END
>  <HTSID>
SWF006601

>  <SMILES>
O=S(=O)(/C=C/c1ccccc1)N1CCOC[C@@]2(CC[C@H](CN3CCOCC3)O2)C1

$$$$
SWF006602
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
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 13 16  1  0  0  0  0
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 16 18  1  0  0  0  0
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 17 20  1  0  0  0  0
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 22 24  1  0  0  0  0
 23 25  1  0  0  0  0
 10 15  1  0  0  0  0
 11 12  1  0  0  0  0
 18 20  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <HTSID>
SWF006602

>  <SMILES>
Cc1nnc(N2CCOCC3(CCCN(C(=O)C4CCOC4)C3)C2)o1

$$$$
SWF006603
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    4.2803    1.3273   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  4  7  1  0  0  0  0
  5  8  1  0  0  0  0
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  6 10  1  0  0  0  0
  8 11  1  0  0  0  0
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 10 13  2  0  0  0  0
 10 14  1  0  0  0  0
 11 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  1  0  0  0  0
 16 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
  5  7  1  0  0  0  0
 12 15  1  0  0  0  0
 17 19  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <HTSID>
SWF006603

>  <SMILES>
O=C(c1cc[nH]c1)N1CCC2(CCC(=O)N2Cc2ccncc2)CC1

$$$$
SWF006604
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    6.3018   -0.2530   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4511   -0.7787   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5258   -0.3995   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
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  5  3  1  1  0  0  0
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  5  7  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
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 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  2  0  0  0  0
 18 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  5  6  1  0  0  0  0
 11 12  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006604

>  <SMILES>
CCc1ccc(C(=O)N2CCCC3(CCC(=O)N3)CC2)cn1

$$$$
SWF006605
Actelion Java MolfileCreator 1.0

 22 24  0  0  0  0  0  0  0  0999 V2000
    5.0295   -4.5476   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
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  6 10  1  0  0  0  0
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 12 14  1  0  0  0  0
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 11 12  2  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <HTSID>
SWF006605

>  <SMILES>
COc1cc(C(=O)N2CCC3(CC2)CC(N(C)C)CO3)on1

$$$$
SWF006606
Actelion Java MolfileCreator 1.0

 23 25  0  0  0  0  0  0  0  0999 V2000
   12.0455   -0.7842   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.5537   -0.9410   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    0.2725   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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   10.2822    1.6428   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   11.7739    1.7996   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   12.3840    3.1699   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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 10 14  1  0  0  0  0
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 15 18  1  0  0  0  0
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 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 10  7  1  1  0  0  0
 13 16  1  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <HTSID>
SWF006606

>  <SMILES>
COCC(=O)N1CCC2(C1)CN(c1ccccc1)C(=O)CN2C

$$$$
SWF006607
Actelion Java MolfileCreator 1.0

 24 27  0  0  0  0  0  0  0  0999 V2000
    5.7173    0.5472   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.7050    0.3907   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    6.6005    1.3852   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    1.8366   -1.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  3  6  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
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  8 10  1  0  0  0  0
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 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
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 13 15  1  0  0  0  0
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 16 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
  4  5  1  0  0  0  0
 11 12  1  0  0  0  0
 15 16  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006607

>  <SMILES>
O=C1CC2(CCN(C(=O)C3(F)CC3)CC2)CN1Cc1cccnc1

$$$$
SWF006608
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.3301   -0.0000   -0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
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    0.0000   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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  3  5  1  0  0  0  0
  4  6  2  0  0  0  0
  5  7  2  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 11 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 16 18  1  0  0  0  0
 17 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 23 21  1  1  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 24 26  1  0  0  0  0
 25 27  1  0  0  0  0
  6  7  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <HTSID>
SWF006608

>  <SMILES>
O=C1COC2(CCN(C(=O)C3CCOC3)CC2)CN1Cc1cccc(F)c1

$$$$
SWF006609
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
    4.2221   -2.5537   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9721   -1.2546   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7549   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9684   -0.1399   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4639   -1.0978   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -1.3703   -0.1399   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568   -2.2418   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.8093  -10.3052   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0724  -11.5187   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1  3  1  0  0  0  0
  2  4  2  0  0  0  0
  2  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  2  0  0  0  0
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 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 14 16  1  0  0  0  0
 15 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 24 26  2  0  0  0  0
 26 27  1  0  0  0  0
  4  6  1  0  0  0  0
 12 13  1  0  0  0  0
 17 18  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006609

>  <SMILES>
Cc1nc(CN2CC3(CCN(C(=O)c4ccc(O)cc4)CC3)CC2=O)cs1

$$$$
SWF006610
Actelion Java MolfileCreator 1.0

 20 22  0  0  0  0  0  0  0  0999 V2000
    6.0622    1.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5622    0.1340   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5622    1.8660   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    6.9282    1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301    1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1962   -0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4641    0.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3301   -1.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -0.5000   -1.3660   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  6  8  1  0  0  0  0
  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 12 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 15 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
  9 10  1  0  0  0  0
 14 15  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <HTSID>
SWF006610

>  <SMILES>
CS(=O)(=O)N1CCC2(CCC(=O)N(CC3CC3)C2)CC1

$$$$
SWF006611
Actelion Java MolfileCreator 1.0

 25 28  0  0  0  0  0  0  0  0999 V2000
    2.8255   -3.1637   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5686   -2.4945   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.4641   -1.5000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0468   -1.8364   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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    3.8424    0.5540   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  3  5  1  0  0  0  0
  4  6  1  0  0  0  0
  4  7  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  1  0  0  0
  7 10  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  2  0  0  0  0
  9 13  1  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
 13 16  2  0  0  0  0
 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  1  0  0  0  0
  5  6  1  0  0  0  0
 11 14  1  0  0  0  0
 16 18  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006611

>  <SMILES>
Cn1cnc(C(=O)N2CCC3(CC2)C(=O)NCC3c2ccccc2)n1

$$$$
SWF006612
Actelion Java MolfileCreator 1.0

 24 26  0  0  0  0  0  0  0  0999 V2000
    3.8971   -0.0000   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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    3.1471    1.2990   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
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    5.1962    0.7500   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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   -5.7342   -8.5607   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7342  -10.0607   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4352  -10.8107   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  1  3  2  0  0  0  0
  1  4  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  1  0  0  0
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  7  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
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 13 15  1  0  0  0  0
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 17 18  2  0  0  0  0
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 23 24  1  0  0  0  0
 11 12  1  0  0  0  0
 14 15  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <HTSID>
SWF006612

>  <SMILES>
COc1ccc(CN2CC3(CCC(CNS(C)(=O)=O)CO3)C2)cc1

$$$$
SWF006613
Actelion Java MolfileCreator 1.0

 27 30  0  0  0  0  0  0  0  0999 V2000
   -4.2567   -1.9623   -0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  1  0  0  0  0
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  2  4  2  0  0  0  0
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  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
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 14 17  1  0  0  0  0
 15 18  2  0  0  0  0
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 16 20  2  0  0  0  0
 17 21  2  0  0  0  0
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 25 27  1  0  0  0  0
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 12 13  1  0  0  0  0
 20 21  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <HTSID>
SWF006613

>  <SMILES>
Cn1ccc(NC(=O)C2(n3ccnc3)CCN(C(=O)c3cscn3)CC2)n1

$$$$
SWF006614
Actelion Java MolfileCreator 1.0

 24 27  0  0  1  0  0  0  0  0999 V2000
    0.8660    1.0000   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8660   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7321   -0.5000   -0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
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    2.5981   -0.0000   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
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  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  7  4  1  6  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  1  0  0  0  0
  7 11  1  0  0  0  0
  7 12  1  0  0  0  0
  7 13  1  0  0  0  0
  8 14  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 20 22  1  0  0  0  0
 21 23  2  0  0  0  0
 22 24  2  0  0  0  0
 10 15  1  0  0  0  0
 13 14  1  0  0  0  0
 16 17  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <HTSID>
SWF006614

>  <SMILES>
O=C([C@H]1CCC[C@]12CCN(Cc1cccnc1)C2)N1CCOCC1

$$$$
SWF006615
Actelion Java MolfileCreator 1.0

 23 26  0  0  0  0  0  0  0  0999 V2000
    0.0217   -5.0831   -0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1919   -4.2014   -0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7717   -2.7748   -0.0000 C   0  0  0  0  0  0  0 